AAED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.58626904
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.58626904
3L-phenylalanine metabolic process (GO:0006558)6.33681773
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.33681773
5aromatic amino acid family catabolic process (GO:0009074)5.64859256
6glyoxylate metabolic process (GO:0046487)5.34450060
7alpha-linolenic acid metabolic process (GO:0036109)5.31444451
8bile acid biosynthetic process (GO:0006699)5.21278741
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.05669064
10fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00306564
11sulfur amino acid catabolic process (GO:0000098)4.94156223
12cysteine metabolic process (GO:0006534)4.88670327
13indole-containing compound catabolic process (GO:0042436)4.82629401
14indolalkylamine catabolic process (GO:0046218)4.82629401
15tryptophan catabolic process (GO:0006569)4.82629401
16kynurenine metabolic process (GO:0070189)4.72910179
17tryptophan metabolic process (GO:0006568)4.71600882
18peptidyl-glutamic acid carboxylation (GO:0017187)4.71508588
19protein carboxylation (GO:0018214)4.71508588
20negative regulation of fibrinolysis (GO:0051918)4.64285192
21complement activation, alternative pathway (GO:0006957)4.63565111
22lysine metabolic process (GO:0006553)4.57193662
23lysine catabolic process (GO:0006554)4.57193662
24urea cycle (GO:0000050)4.52129129
25urea metabolic process (GO:0019627)4.52129129
26regulation of protein activation cascade (GO:2000257)4.50421513
27high-density lipoprotein particle remodeling (GO:0034375)4.42686665
28bile acid metabolic process (GO:0008206)4.41259773
29respiratory chain complex IV assembly (GO:0008535)4.40442569
30regulation of fibrinolysis (GO:0051917)4.31492066
31amino-acid betaine metabolic process (GO:0006577)4.28422507
32tyrosine metabolic process (GO:0006570)4.27281291
33regulation of complement activation (GO:0030449)4.24662838
34cytochrome complex assembly (GO:0017004)4.20116239
35aromatic amino acid family metabolic process (GO:0009072)4.18223495
36nitrogen cycle metabolic process (GO:0071941)4.17876544
37platelet dense granule organization (GO:0060155)4.17811973
38DNA deamination (GO:0045006)4.17329052
39serine family amino acid catabolic process (GO:0009071)4.12742241
40valine metabolic process (GO:0006573)4.12361274
41homocysteine metabolic process (GO:0050667)4.11568176
42regulation of triglyceride catabolic process (GO:0010896)4.10317897
43protein complex biogenesis (GO:0070271)4.07202614
44water-soluble vitamin biosynthetic process (GO:0042364)4.04565221
45triglyceride homeostasis (GO:0070328)4.01617783
46acylglycerol homeostasis (GO:0055090)4.01617783
47ketone body metabolic process (GO:1902224)3.97950589
48L-fucose catabolic process (GO:0042355)3.95326704
49fucose catabolic process (GO:0019317)3.95326704
50L-fucose metabolic process (GO:0042354)3.95326704
51reverse cholesterol transport (GO:0043691)3.93004110
52inositol phosphate catabolic process (GO:0071545)3.91545630
53alpha-amino acid catabolic process (GO:1901606)3.91192346
54phospholipid efflux (GO:0033700)3.90091632
55inositol phosphate dephosphorylation (GO:0046855)3.86791201
56phosphorylated carbohydrate dephosphorylation (GO:0046838)3.86791201
57plasma lipoprotein particle clearance (GO:0034381)3.86058863
58behavioral response to nicotine (GO:0035095)3.84070440
59protein-lipid complex remodeling (GO:0034368)3.83184219
60macromolecular complex remodeling (GO:0034367)3.83184219
61plasma lipoprotein particle remodeling (GO:0034369)3.83184219
62fatty acid beta-oxidation (GO:0006635)3.82712772
63cellular glucuronidation (GO:0052695)3.80772575
64regulation of hexokinase activity (GO:1903299)3.78698286
65regulation of glucokinase activity (GO:0033131)3.78698286
66ethanol oxidation (GO:0006069)3.76947492
67regulation of cholesterol esterification (GO:0010872)3.72826207
68fatty acid oxidation (GO:0019395)3.72135083
69cellular amino acid catabolic process (GO:0009063)3.71685579
702-oxoglutarate metabolic process (GO:0006103)3.71458140
71bile acid and bile salt transport (GO:0015721)3.67151216
72glycine metabolic process (GO:0006544)3.67024449
73cellular ketone body metabolic process (GO:0046950)3.66734801
74coenzyme catabolic process (GO:0009109)3.66316525
75mitochondrial respiratory chain complex assembly (GO:0033108)3.65427324
76lipid oxidation (GO:0034440)3.64668943
77fatty acid catabolic process (GO:0009062)3.61355729
78serine family amino acid metabolic process (GO:0009069)3.61109987
79imidazole-containing compound metabolic process (GO:0052803)3.59839290
80benzene-containing compound metabolic process (GO:0042537)3.58964617
81cellular modified amino acid catabolic process (GO:0042219)3.54359037
82aldehyde catabolic process (GO:0046185)3.53993179
83plasma lipoprotein particle assembly (GO:0034377)3.53411541
84cholesterol efflux (GO:0033344)3.52737573
85monocarboxylic acid catabolic process (GO:0072329)3.52605484
86acetyl-CoA metabolic process (GO:0006084)3.48848464
87carboxylic acid catabolic process (GO:0046395)3.48832267
88organic acid catabolic process (GO:0016054)3.48832267
89carnitine metabolic process (GO:0009437)3.48531036
90serine family amino acid biosynthetic process (GO:0009070)3.46025148
91negative regulation of sterol transport (GO:0032372)3.44399258
92negative regulation of cholesterol transport (GO:0032375)3.44399258
93indolalkylamine metabolic process (GO:0006586)3.44174598
94short-chain fatty acid metabolic process (GO:0046459)3.42950231
95aspartate family amino acid catabolic process (GO:0009068)3.40268120
96mitochondrial respiratory chain complex I assembly (GO:0032981)3.39713948
97NADH dehydrogenase complex assembly (GO:0010257)3.39713948
98mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.39713948
99positive regulation of lipoprotein lipase activity (GO:0051006)3.38460138
100positive regulation of triglyceride lipase activity (GO:0061365)3.38460138
101amine catabolic process (GO:0009310)3.37574058
102cellular biogenic amine catabolic process (GO:0042402)3.37574058
103glucuronate metabolic process (GO:0019585)3.37424100
104uronic acid metabolic process (GO:0006063)3.37424100
105phospholipid homeostasis (GO:0055091)3.35761131
106positive regulation of lipid catabolic process (GO:0050996)3.34629196
107response to nitrosative stress (GO:0051409)3.34509484
108opsonization (GO:0008228)3.34414019
109cofactor catabolic process (GO:0051187)3.33742776
110positive regulation of fatty acid beta-oxidation (GO:0032000)3.33267200
111preassembly of GPI anchor in ER membrane (GO:0016254)3.32829964
112fibrinolysis (GO:0042730)3.31166715
113regulation of cholesterol metabolic process (GO:0090181)3.31066358
114branched-chain amino acid metabolic process (GO:0009081)3.30405679
115branched-chain amino acid catabolic process (GO:0009083)3.30392188
116signal peptide processing (GO:0006465)3.29834963
117polyol catabolic process (GO:0046174)3.29771816
118protein-lipid complex assembly (GO:0065005)3.29197509
119arginine metabolic process (GO:0006525)3.26408334
120tricarboxylic acid metabolic process (GO:0072350)3.25398620
121regulation of cholesterol homeostasis (GO:2000188)3.24147448
122cholesterol homeostasis (GO:0042632)3.23074741
123glutamate metabolic process (GO:0006536)3.22061448
124mannosylation (GO:0097502)3.19841614
125regulation of type B pancreatic cell apoptotic process (GO:2000674)3.04841768
126piRNA metabolic process (GO:0034587)3.00617618
127response to pheromone (GO:0019236)2.98252968
128axoneme assembly (GO:0035082)2.90843863
129glycerophospholipid catabolic process (GO:0046475)2.89987323
130regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.85547607
131S-adenosylmethionine metabolic process (GO:0046500)2.85420620
132cellular response to ATP (GO:0071318)2.85017194
133regulation of B cell apoptotic process (GO:0002902)2.79988954
134endocrine pancreas development (GO:0031018)2.79293436
135negative regulation of execution phase of apoptosis (GO:1900118)2.77530259
136organelle membrane fusion (GO:0090174)2.77025386
137mitotic cell cycle arrest (GO:0071850)2.76870563
138endosome to pigment granule transport (GO:0043485)2.75367779
139endosome to melanosome transport (GO:0035646)2.75367779
140C-terminal protein lipidation (GO:0006501)2.73559277
141insulin secretion (GO:0030073)2.72517680
142mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71044515
143magnesium ion transport (GO:0015693)2.69745811
144negative regulation of telomere maintenance (GO:0032205)2.69277044
145positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.67409570
146nephron epithelium morphogenesis (GO:0072088)2.67142557
147nephron tubule morphogenesis (GO:0072078)2.67142557
148nitric oxide mediated signal transduction (GO:0007263)2.66808239
149alanine transport (GO:0032328)2.66374755
150peptidyl-histidine modification (GO:0018202)2.65836453
151regulation of memory T cell differentiation (GO:0043380)2.63898539
152dopamine transport (GO:0015872)2.61091532
153positive regulation of prostaglandin secretion (GO:0032308)2.60924363
154kidney morphogenesis (GO:0060993)2.59864945
155nitric oxide biosynthetic process (GO:0006809)2.59328241
156autophagic vacuole fusion (GO:0000046)2.58825368
157positive regulation of glycolytic process (GO:0045821)2.58645482
158proteasome assembly (GO:0043248)2.57625490
159detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.53719038
160detection of light stimulus involved in sensory perception (GO:0050962)2.52827813
161detection of light stimulus involved in visual perception (GO:0050908)2.52827813
162C-terminal protein amino acid modification (GO:0018410)2.51570935
163negative regulation of membrane potential (GO:0045837)2.48460052
164positive regulation of protein autophosphorylation (GO:0031954)2.48069165
165protein-cofactor linkage (GO:0018065)2.47607715
166parental behavior (GO:0060746)2.47138528
167regulation of cilium movement (GO:0003352)2.46636768
168purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44494697
1693-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44494697
170keratinocyte development (GO:0003334)2.43747126
171basic amino acid transport (GO:0015802)2.43083671
172xenobiotic catabolic process (GO:0042178)2.42196845
173regulation of neurotransmitter uptake (GO:0051580)2.41789793
174regulation of action potential (GO:0098900)2.41782317
175cornea development in camera-type eye (GO:0061303)2.41026926
176positive regulation of calcium ion import (GO:0090280)2.40590177
177proline transport (GO:0015824)2.40196248
178photoreceptor cell maintenance (GO:0045494)2.39324765
179positive regulation of meiosis (GO:0045836)2.38748690
180negative regulation of protein autophosphorylation (GO:0031953)2.38274595
181protein K6-linked ubiquitination (GO:0085020)2.36525854
182adenosine metabolic process (GO:0046085)2.36231780
183positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.34892596
184aggressive behavior (GO:0002118)2.34685357
185adaptation of signaling pathway (GO:0023058)2.34498604
186positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.34451856
187maturation of 5.8S rRNA (GO:0000460)2.34051380
188prenylation (GO:0097354)2.33054501
189protein prenylation (GO:0018342)2.33054501
190organic cation transport (GO:0015695)2.32555018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.55068768
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.71462240
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.96541854
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.41828754
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.23928409
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.97175197
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.33844517
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08053482
9ZNF274_21170338_ChIP-Seq_K562_Hela3.49111514
10VDR_22108803_ChIP-Seq_LS180_Human3.37444977
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29207373
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93155922
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.73302297
14GBX2_23144817_ChIP-Seq_PC3_Human2.57664520
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47865388
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.43455361
17CLOCK_20551151_ChIP-Seq_293T_Human2.37214976
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34064452
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.34045374
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19920081
21GATA1_22025678_ChIP-Seq_K562_Human2.19725553
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.09944326
23IRF8_22096565_ChIP-ChIP_GC-B_Human2.07619863
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.07048922
25FUS_26573619_Chip-Seq_HEK293_Human1.93874735
26IGF1R_20145208_ChIP-Seq_DFB_Human1.89098204
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88020533
28EWS_26573619_Chip-Seq_HEK293_Human1.87183621
29EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85531009
30P300_19829295_ChIP-Seq_ESCs_Human1.83417835
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81072923
32ER_23166858_ChIP-Seq_MCF-7_Human1.80460919
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77805442
34STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.76951415
35EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76667687
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.69562166
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.69452534
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64516931
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.62730093
40TP53_22573176_ChIP-Seq_HFKS_Human1.61300962
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58564429
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.55430599
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54434326
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.53459904
45FOXA1_27270436_Chip-Seq_PROSTATE_Human1.53459904
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.51239233
47NANOG_19829295_ChIP-Seq_ESCs_Human1.51170122
48SOX2_19829295_ChIP-Seq_ESCs_Human1.51170122
49BCAT_22108803_ChIP-Seq_LS180_Human1.50986827
50NOTCH1_21737748_ChIP-Seq_TLL_Human1.50398023
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.49916622
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47937083
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.44550816
54TAF15_26573619_Chip-Seq_HEK293_Human1.42609066
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.36933627
56CBP_20019798_ChIP-Seq_JUKART_Human1.36281020
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36281020
58SMAD4_21799915_ChIP-Seq_A2780_Human1.36255924
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.34400269
60VDR_23849224_ChIP-Seq_CD4+_Human1.34388505
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.33112983
62AR_25329375_ChIP-Seq_VCAP_Human1.32942223
63BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32641318
64ELK1_19687146_ChIP-ChIP_HELA_Human1.30458724
65GATA3_21878914_ChIP-Seq_MCF-7_Human1.29373418
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28578424
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.27512985
68STAT3_23295773_ChIP-Seq_U87_Human1.26983722
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25911936
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25462765
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24968094
72CDX2_22108803_ChIP-Seq_LS180_Human1.24930161
73STAT3_18555785_Chip-Seq_ESCs_Mouse1.23678385
74TCF4_22108803_ChIP-Seq_LS180_Human1.23030037
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22308538
76P53_22387025_ChIP-Seq_ESCs_Mouse1.22093451
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.21399255
78NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20632222
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.20375864
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20049930
81EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.19760659
82SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18293511
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17534571
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.17322911
85TCF4_23295773_ChIP-Seq_U87_Human1.16954511
86NCOR_22424771_ChIP-Seq_293T_Human1.16920134
87GATA3_26560356_Chip-Seq_TH2_Human1.16650556
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16498702
89SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15911979
90SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15888136
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14836824
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13497294
93TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12912813
94BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12311042
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11809884
96HNF4A_19822575_ChIP-Seq_HepG2_Human1.11368664
97RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10917495
98MYC_18940864_ChIP-ChIP_HL60_Human1.10531268
99SMAD4_21741376_ChIP-Seq_EPCs_Human1.09785713
100PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08819152
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.08701603
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07877964
103GATA4_25053715_ChIP-Seq_YYC3_Human1.06973346
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.06458149
105SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05755129
106Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05665043
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05506662
108HOXB7_26014856_ChIP-Seq_BT474_Human1.05036602
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.04908315
110P300_18555785_Chip-Seq_ESCs_Mouse1.04536779
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04360216
112OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03678563
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.03427886
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.03219203
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.03164803
116ELF1_17652178_ChIP-ChIP_JURKAT_Human1.03162797
117SOX2_18555785_Chip-Seq_ESCs_Mouse1.03103410
118EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.03091021
119RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02502628
120MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02455309
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02027353
122SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02020943
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.02012696
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01686769
125PHF8_20622853_ChIP-Seq_HELA_Human1.00294295
126NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98332792
127ZNF263_19887448_ChIP-Seq_K562_Human0.98186475
128RUNX2_22187159_ChIP-Seq_PCA_Human0.97485637
129IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.97407364
130FOXH1_21741376_ChIP-Seq_EPCs_Human0.96799241
131RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92120619
132SCL_19346495_ChIP-Seq_HPC-7_Human0.91564571
133NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90829412
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90679409
135HTT_18923047_ChIP-ChIP_STHdh_Human0.90108948
136ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89419120
137SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88669715
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88557270
139BRD4_27068464_Chip-Seq_AML-cells_Mouse0.86545760
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84449649
141FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82581814
142STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81128284
143SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.80422824
144SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.80015647
145GATA1_19941826_ChIP-Seq_K562_Human0.79726996
146SRF_21415370_ChIP-Seq_HL-1_Mouse0.79130052
147IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78312856
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77715805
149TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77339779
150GATA1_22383799_ChIP-Seq_G1ME_Mouse0.76162157
151GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.75565591
152FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.74795345
153AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74274013
154GATA2_21666600_ChIP-Seq_HMVEC_Human0.73324262
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.71803887
156NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71735197
157NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71735197
158TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71427214
159MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.71420908
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.69986093
161AR_20517297_ChIP-Seq_VCAP_Human0.69928279
162ERG_20887958_ChIP-Seq_HPC-7_Mouse0.69832428
163FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69151032
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.68862387
165SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68566393
166TBX20_22328084_ChIP-Seq_HEART_Mouse0.68235912
167TBX20_22080862_ChIP-Seq_HEART_Mouse0.68235912
168TRIM28_21343339_ChIP-Seq_HEK293_Human0.68173006
169GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67391623
170IRF8_27001747_Chip-Seq_BMDM_Mouse0.67093859
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.66734908
172SOX2_20726797_ChIP-Seq_SW620_Human0.66379805
173GATA6_25053715_ChIP-Seq_YYC3_Human0.65064412
174CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64835257
175GATA1_19941827_ChIP-Seq_MEL_Mouse0.64804354
176SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.64464130
177GATA2_19941826_ChIP-Seq_K562_Human0.64299980
178E2F1_18555785_ChIP-Seq_MESCs_Mouse0.64232432
179PPAR_26484153_Chip-Seq_NCI-H1993_Human0.63257030
180ESR2_21235772_ChIP-Seq_MCF-7_Human0.62792933
181CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62602610
182RARA_24833708_ChIP-Seq_LIVER_Mouse0.62249678
183FOXA1_25552417_ChIP-Seq_VCAP_Human0.61807677
184GABP_17652178_ChIP-ChIP_JURKAT_Human0.61379997
185HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.61273833
186ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.61194203
187RARB_24833708_ChIP-Seq_LIVER_Mouse0.60935889
188CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.60130833
189BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.59223125
190TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.59209656
191FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.57578730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.64388080
2MP0005360_urolithiasis5.94311352
3MP0005365_abnormal_bile_salt5.30161477
4MP0005085_abnormal_gallbladder_physiolo5.19798166
5MP0008875_abnormal_xenobiotic_pharmacok4.08591223
6MP0003806_abnormal_nucleotide_metabolis3.96216740
7MP0003252_abnormal_bile_duct3.21430020
8MP0010329_abnormal_lipoprotein_level3.00700054
9MP0003195_calcinosis2.97570502
10MP0009840_abnormal_foam_cell2.92823103
11MP0005083_abnormal_biliary_tract2.66594643
12MP0001666_abnormal_nutrient_absorption2.56748656
13MP0005379_endocrine/exocrine_gland_phen2.55864440
14MP0005332_abnormal_amino_acid2.51577117
15MP0000372_irregular_coat_pigmentation2.49445942
16MP0008877_abnormal_DNA_methylation2.41953989
17MP0003191_abnormal_cellular_cholesterol2.39349555
18MP0000569_abnormal_digit_pigmentation2.39301678
19MP0002163_abnormal_gland_morphology2.27663956
20MP0002876_abnormal_thyroid_physiology2.26178568
21MP0003787_abnormal_imprinting2.16624480
22MP0006072_abnormal_retinal_apoptosis2.15878255
23MP0005174_abnormal_tail_pigmentation2.15406970
24MP0005645_abnormal_hypothalamus_physiol2.12412066
25MP0000609_abnormal_liver_physiology2.08379851
26MP0002138_abnormal_hepatobiliary_system1.99966885
27MP0005551_abnormal_eye_electrophysiolog1.95029838
28MP0005646_abnormal_pituitary_gland1.93624316
29MP0002118_abnormal_lipid_homeostasis1.93037578
30MP0009780_abnormal_chondrocyte_physiolo1.87090714
31MP0005319_abnormal_enzyme/_coenzyme1.81374690
32MP0009046_muscle_twitch1.77796869
33MP0003656_abnormal_erythrocyte_physiolo1.77421355
34MP0003868_abnormal_feces_composition1.69345905
35MP0004019_abnormal_vitamin_homeostasis1.68856578
36MP0000013_abnormal_adipose_tissue1.67035100
37MP0003186_abnormal_redox_activity1.66782380
38MP0001986_abnormal_taste_sensitivity1.63509722
39MP0002938_white_spotting1.61537589
40MP0000427_abnormal_hair_cycle1.61231408
41MP0005075_abnormal_melanosome_morpholog1.60718090
42MP0005253_abnormal_eye_physiology1.58464209
43MP0001764_abnormal_homeostasis1.56678578
44MP0001501_abnormal_sleep_pattern1.54673421
45MP0009643_abnormal_urine_homeostasis1.52374358
46MP0010386_abnormal_urinary_bladder1.49333970
47MP0000015_abnormal_ear_pigmentation1.47952903
48MP0005584_abnormal_enzyme/coenzyme_acti1.46659506
49MP0002102_abnormal_ear_morphology1.45273583
50MP0003705_abnormal_hypodermis_morpholog1.44140150
51MP0002638_abnormal_pupillary_reflex1.42545070
52MP0004885_abnormal_endolymph1.42532276
53MP0005670_abnormal_white_adipose1.41346928
54MP0002909_abnormal_adrenal_gland1.39760889
55MP0010368_abnormal_lymphatic_system1.33701928
56MP0005389_reproductive_system_phenotype1.32032455
57MP0008872_abnormal_physiological_respon1.31199966
58MP0005451_abnormal_body_composition1.28461508
59MP0009697_abnormal_copulation1.27078945
60MP0009745_abnormal_behavioral_response1.26259873
61MP0005220_abnormal_exocrine_pancreas1.25383032
62MP0003646_muscle_fatigue1.24433017
63MP0008438_abnormal_cutaneous_collagen1.24329255
64MP0000598_abnormal_liver_morphology1.23644492
65MP0006036_abnormal_mitochondrial_physio1.20660426
66MP0001968_abnormal_touch/_nociception1.19587724
67MP0005167_abnormal_blood-brain_barrier1.19571687
68MP0000516_abnormal_urinary_system1.18453760
69MP0005367_renal/urinary_system_phenotyp1.18453760
70MP0006054_spinal_hemorrhage1.17700024
71MP0004130_abnormal_muscle_cell1.16933037
72MP0002837_dystrophic_cardiac_calcinosis1.14993484
73MP0002160_abnormal_reproductive_system1.14845726
74MP0004142_abnormal_muscle_tone1.12634040
75MP0001984_abnormal_olfaction1.12135183
76MP0004215_abnormal_myocardial_fiber1.11395810
77MP0005636_abnormal_mineral_homeostasis1.10758011
78MP0008469_abnormal_protein_level1.10028179
79MP0005408_hypopigmentation1.07822310
80MP0003786_premature_aging1.06062784
81MP0005410_abnormal_fertilization1.05065655
82MP0008995_early_reproductive_senescence1.03766861
83MP0002148_abnormal_hypersensitivity_rea1.02891968
84MP0002095_abnormal_skin_pigmentation1.02797066
85MP0009763_increased_sensitivity_to1.01585879
86MP0003724_increased_susceptibility_to1.01198546
87MP0005058_abnormal_lysosome_morphology0.99725040
88MP0008775_abnormal_heart_ventricle0.98798365
89MP0000538_abnormal_urinary_bladder0.97948517
90MP0009764_decreased_sensitivity_to0.97401881
91MP0003136_yellow_coat_color0.96752464
92MP0001905_abnormal_dopamine_level0.96520701
93MP0001765_abnormal_ion_homeostasis0.95431725
94MP0001919_abnormal_reproductive_system0.93968771
95MP0003283_abnormal_digestive_organ0.93588716
96MP0002078_abnormal_glucose_homeostasis0.93396399
97MP0001661_extended_life_span0.88937535
98MP0009642_abnormal_blood_homeostasis0.88377518
99MP0004133_heterotaxia0.88159017
100MP0005448_abnormal_energy_balance0.87360258
101MP0001485_abnormal_pinna_reflex0.85444805
102MP0005666_abnormal_adipose_tissue0.83334350
103MP0003172_abnormal_lysosome_physiology0.82961671
104MP0002557_abnormal_social/conspecific_i0.82697983
105MP0003436_decreased_susceptibility_to0.82469581
106MP0002971_abnormal_brown_adipose0.82358873
107MP0003300_gastrointestinal_ulcer0.81578442
108MP0005464_abnormal_platelet_physiology0.81271389
109MP0001853_heart_inflammation0.80686475
110MP0002272_abnormal_nervous_system0.80641334
111MP0001970_abnormal_pain_threshold0.80210740
112MP0002277_abnormal_respiratory_mucosa0.80066623
113MP0005334_abnormal_fat_pad0.79797812
114MP0001756_abnormal_urination0.79560237
115MP0003953_abnormal_hormone_level0.79517477
116MP0000647_abnormal_sebaceous_gland0.78724739
117MP0004147_increased_porphyrin_level0.78075080
118MP0005376_homeostasis/metabolism_phenot0.77375115
119MP0005084_abnormal_gallbladder_morpholo0.76097812
120MP0002090_abnormal_vision0.76004168
121MP0010234_abnormal_vibrissa_follicle0.74643920
122MP0003137_abnormal_impulse_conducting0.73272797
123MP0003011_delayed_dark_adaptation0.73232873
124MP0002877_abnormal_melanocyte_morpholog0.73072269
125MP0001324_abnormal_eye_pigmentation0.73038051
126MP0002229_neurodegeneration0.72679314
127MP0009765_abnormal_xenobiotic_induced0.71662496
128MP0005023_abnormal_wound_healing0.71437353
129MP0002254_reproductive_system_inflammat0.69616193
130MP0000604_amyloidosis0.69388492
131MP0005647_abnormal_sex_gland0.68778777
132MP0005275_abnormal_skin_tensile0.67943950
133MP0000685_abnormal_immune_system0.65738526
134MP0002136_abnormal_kidney_physiology0.64971931
135MP0001845_abnormal_inflammatory_respons0.64894979
136MP0004947_skin_inflammation0.62715277
137MP0005375_adipose_tissue_phenotype0.61237768
138MP0002060_abnormal_skin_morphology0.60532401
139MP0001243_abnormal_dermal_layer0.60505876
140MP0001944_abnormal_pancreas_morphology0.59005264
141MP0003279_aneurysm0.56971415
142MP0005266_abnormal_metabolism0.55329251
143MP0005330_cardiomyopathy0.53978551
144MP0008873_increased_physiological_sensi0.53829700
145MP0009785_altered_susceptibility_to0.53441522
146MP0002269_muscular_atrophy0.51999249
147MP0000343_altered_response_to0.51964069
148MP0005535_abnormal_body_temperature0.51786759
149MP0000249_abnormal_blood_vessel0.51398559
150MP0002166_altered_tumor_susceptibility0.50775139
151MP0002928_abnormal_bile_duct0.50711314
152MP0002419_abnormal_innate_immunity0.49522456
153MP0004264_abnormal_extraembryonic_tissu0.49481677
154MP0004782_abnormal_surfactant_physiolog0.48884522
155MP0009384_cardiac_valve_regurgitation0.48702441
156MP0004272_abnormal_basement_membrane0.48564126
157MP0001533_abnormal_skeleton_physiology0.48543786
158MP0000003_abnormal_adipose_tissue0.48251777
159MP0004043_abnormal_pH_regulation0.48171155
160MP0002168_other_aberrant_phenotype0.47202098
161MP0002693_abnormal_pancreas_physiology0.46540485
162MP0000230_abnormal_systemic_arterial0.46278708
163MP0005164_abnormal_response_to0.46178957
164MP0002295_abnormal_pulmonary_circulatio0.45902238
165MP0001879_abnormal_lymphatic_vessel0.45846604
166MP0006082_CNS_inflammation0.45586051

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.37514537
2Intrahepatic cholestasis (HP:0001406)6.30976387
3Deep venous thrombosis (HP:0002625)5.93822253
4Hypobetalipoproteinemia (HP:0003563)5.56315709
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.37762508
6Xanthomatosis (HP:0000991)5.36082550
7Prolonged partial thromboplastin time (HP:0003645)5.34961712
8Hypoglycemic coma (HP:0001325)4.80678260
9Hyperlipoproteinemia (HP:0010980)4.48784672
10Complement deficiency (HP:0004431)4.35648184
11Ketosis (HP:0001946)4.20838696
12Abnormality of the common coagulation pathway (HP:0010990)4.15264191
13Hypolipoproteinemia (HP:0010981)4.15022841
14Hyperammonemia (HP:0001987)4.11606500
15Abnormality of the intrinsic pathway (HP:0010989)4.06833600
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.89262446
17Fat malabsorption (HP:0002630)3.80737541
18Congenital stationary night blindness (HP:0007642)3.79727201
19Joint hemorrhage (HP:0005261)3.79587920
20Pancreatic cysts (HP:0001737)3.66813061
21Abnormality of fatty-acid metabolism (HP:0004359)3.66193655
22Hypothermia (HP:0002045)3.65458451
23Ketoacidosis (HP:0001993)3.55513940
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.53362836
25Epidermoid cyst (HP:0200040)3.47166062
26Hypoalphalipoproteinemia (HP:0003233)3.45019162
27Abnormality of sulfur amino acid metabolism (HP:0004339)3.44005384
28Abnormality of midbrain morphology (HP:0002418)3.43837195
29Molar tooth sign on MRI (HP:0002419)3.43837195
30Hyperglycinuria (HP:0003108)3.41513488
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.39134700
32Pancreatic fibrosis (HP:0100732)3.35529753
33Hyperglycinemia (HP:0002154)3.35489138
34Abnormality of serine family amino acid metabolism (HP:0010894)3.34478494
35Abnormality of glycine metabolism (HP:0010895)3.34478494
36Abnormality of methionine metabolism (HP:0010901)3.32888625
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.32129367
38Conjugated hyperbilirubinemia (HP:0002908)3.31132611
39Abnormality of the renal cortex (HP:0011035)3.25313297
40Hyperbilirubinemia (HP:0002904)3.19558998
41Hypoglycemic seizures (HP:0002173)3.17045113
42Large for gestational age (HP:0001520)3.16900800
43Abnormality of complement system (HP:0005339)3.13143150
44Progressive macrocephaly (HP:0004481)3.08757012
45Generalized aminoaciduria (HP:0002909)3.08405816
46Steatorrhea (HP:0002570)2.99688321
47True hermaphroditism (HP:0010459)2.94746628
48Hypercholesterolemia (HP:0003124)2.93909866
49Myocardial infarction (HP:0001658)2.92367611
50Dicarboxylic aciduria (HP:0003215)2.91354979
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.91354979
52Acute necrotizing encephalopathy (HP:0006965)2.90398847
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.89442379
54Hypoplasia of the fovea (HP:0007750)2.89442379
55Abnormality of purine metabolism (HP:0004352)2.87984268
56Hyperinsulinemic hypoglycemia (HP:0000825)2.87529662
57Mitochondrial inheritance (HP:0001427)2.83158979
58Nephronophthisis (HP:0000090)2.81873441
59Abnormality of nucleobase metabolism (HP:0010932)2.77681822
60Gout (HP:0001997)2.76445726
61Acanthocytosis (HP:0001927)2.76389680
62Increased CSF lactate (HP:0002490)2.74689300
63Attenuation of retinal blood vessels (HP:0007843)2.74370484
64Skin nodule (HP:0200036)2.71038134
65Polydipsia (HP:0001959)2.70207946
66Abnormal drinking behavior (HP:0030082)2.70207946
67Hepatocellular carcinoma (HP:0001402)2.69333030
68Medial flaring of the eyebrow (HP:0010747)2.64349997
69Metabolic acidosis (HP:0001942)2.64245097
70Abnormal rod and cone electroretinograms (HP:0008323)2.63315380
71Abnormality of serum amino acid levels (HP:0003112)2.58526300
72Late onset (HP:0003584)2.58320349
73Renal cortical cysts (HP:0000803)2.57975720
74Abnormality of pyrimidine metabolism (HP:0004353)2.57076930
75Vascular calcification (HP:0004934)2.56411630
76Abnormality of the renal medulla (HP:0100957)2.54232046
77Acute encephalopathy (HP:0006846)2.53137569
78Type II lissencephaly (HP:0007260)2.49791584
79Tubular atrophy (HP:0000092)2.49163778
80Methylmalonic acidemia (HP:0002912)2.45981434
81Delayed CNS myelination (HP:0002188)2.45836716
82Stomatitis (HP:0010280)2.44123648
83Lethargy (HP:0001254)2.42288651
84Hepatocellular necrosis (HP:0001404)2.40760489
85Cardiovascular calcification (HP:0011915)2.40438703
86Abnormal mitochondria in muscle tissue (HP:0008316)2.39187879
87Furrowed tongue (HP:0000221)2.39049116
88Tongue fasciculations (HP:0001308)2.38812061
89Congenital, generalized hypertrichosis (HP:0004540)2.37753374
90Mitral stenosis (HP:0001718)2.37299890
91Systemic lupus erythematosus (HP:0002725)2.36121860
92Abnormality of the fovea (HP:0000493)2.35586232
93Glomerulonephritis (HP:0000099)2.35564847
94Esophageal varix (HP:0002040)2.34249497
95Abnormal gallbladder morphology (HP:0012437)2.33960952
96Cerebral edema (HP:0002181)2.33720957
973-Methylglutaconic aciduria (HP:0003535)2.31569554
98Lipid accumulation in hepatocytes (HP:0006561)2.31438237
99Congenital sensorineural hearing impairment (HP:0008527)2.31213890
100Hemiparesis (HP:0001269)2.31003309
101Methylmalonic aciduria (HP:0012120)2.30006144
102Hematochezia (HP:0002573)2.28437760
103Hyperglycemia (HP:0003074)2.26566081
104Spontaneous abortion (HP:0005268)2.25590703
105Abnormal cartilage morphology (HP:0002763)2.25491336
106Vacuolated lymphocytes (HP:0001922)2.25189898
107Disproportionate short-trunk short stature (HP:0003521)2.24938403
108Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24733899
109Abnormality of alanine metabolism (HP:0010916)2.24733899
110Hyperalaninemia (HP:0003348)2.24733899
111Increased hepatocellular lipid droplets (HP:0006565)2.23974990
112Symptomatic seizures (HP:0011145)2.23355249
113Abolished electroretinogram (ERG) (HP:0000550)2.21351278
114Decreased electroretinogram (ERG) amplitude (HP:0000654)2.20014271
115Intestinal atresia (HP:0011100)2.19114695
116Decreased central vision (HP:0007663)2.18541133
117Myoglobinuria (HP:0002913)2.18408108
118Thyroiditis (HP:0100646)2.17867302
119Cholelithiasis (HP:0001081)2.17395889
120Pancreatitis (HP:0001733)2.16211790
121Nausea (HP:0002018)2.13162850
122Recurrent gram-negative bacterial infections (HP:0005420)2.13149742
123Spastic diplegia (HP:0001264)2.11046165
124Renal Fanconi syndrome (HP:0001994)2.10539874
125Gaze-evoked nystagmus (HP:0000640)2.09939674
126Abnormality of vitamin B metabolism (HP:0004340)2.09795787
127Polyuria (HP:0000103)2.09589676
128Hyperventilation (HP:0002883)2.06394013
129Aplasia/hypoplasia of the uterus (HP:0008684)2.06132440
130Abnormality of transition element cation homeostasis (HP:0011030)2.06046686
131Albinism (HP:0001022)2.05837670
132Malnutrition (HP:0004395)2.05399529
133Thrombophlebitis (HP:0004418)2.04137562
134Abnormality of iron homeostasis (HP:0011031)2.03623590
135Neoplasm of the adrenal cortex (HP:0100641)2.03294630
136Conjunctival hamartoma (HP:0100780)2.02520236
137Hypoalbuminemia (HP:0003073)2.00929287
138Abnormal albumin level (HP:0012116)2.00929287
139Hypoplasia of the uterus (HP:0000013)2.00789474
140Vomiting (HP:0002013)2.00269458
141Gingival bleeding (HP:0000225)1.99880817
142Polycythemia (HP:0001901)1.99254359
143Chronic hepatic failure (HP:0100626)1.99165802
144Metaphyseal dysplasia (HP:0100255)1.98624182
145Brushfield spots (HP:0001088)1.98083126
146Cholecystitis (HP:0001082)1.97214943
147Abnormal gallbladder physiology (HP:0012438)1.97214943
148Abnormality of urine glucose concentration (HP:0011016)1.96368197
149Glycosuria (HP:0003076)1.96368197
150Irritability (HP:0000737)1.95823707
151Cystic liver disease (HP:0006706)1.94496382
152Sclerocornea (HP:0000647)1.93053819
153Hemorrhage of the eye (HP:0011885)1.91643328
154Elevated hepatic transaminases (HP:0002910)1.90943134
155Hypochromic microcytic anemia (HP:0004840)1.90788241
156Optic disc pallor (HP:0000543)1.89848080
157Proximal tubulopathy (HP:0000114)1.88801036
158Hyperuricemia (HP:0002149)1.88517010
159Increased purine levels (HP:0004368)1.88517010
160Abnormality of the pancreatic islet cells (HP:0006476)1.88441355
161Abnormality of endocrine pancreas physiology (HP:0012093)1.88441355
162Protuberant abdomen (HP:0001538)1.88403369
163Abnormal enzyme/coenzyme activity (HP:0012379)1.87923686
164Congenital hepatic fibrosis (HP:0002612)1.87705247
165Muscle fibrillation (HP:0010546)1.87566953
166Hamartoma of the eye (HP:0010568)1.87207079
167Severe muscular hypotonia (HP:0006829)1.86819743
168Agitation (HP:0000713)1.86127441
169Nonimmune hydrops fetalis (HP:0001790)1.86033254
170Lactic acidosis (HP:0003128)1.85714166
171Increased serum lactate (HP:0002151)1.84804070
172Progressive inability to walk (HP:0002505)1.83814073
173Opisthotonus (HP:0002179)1.83525465
174Abnormality of proline metabolism (HP:0010907)1.83138539
175Hydroxyprolinuria (HP:0003080)1.83138539
176Tachypnea (HP:0002789)1.82129310
177Hepatic necrosis (HP:0002605)1.82024807
178Abnormality of renal resorption (HP:0011038)1.80094210
179Respiratory failure (HP:0002878)1.79612879
180Abnormal glycosylation (HP:0012345)1.76690525
181Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76690525
182Abnormal protein N-linked glycosylation (HP:0012347)1.76690525
183Abnormal protein glycosylation (HP:0012346)1.76690525
184Abnormality of the pons (HP:0007361)1.75710337
185Decreased circulating renin level (HP:0003351)1.75640183
186Male pseudohermaphroditism (HP:0000037)1.74809938
187Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74561675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.44768693
2ERN14.02025680
3ADRBK23.27730589
4FGFR42.99911640
5FLT32.99245421
6SIK12.97691003
7TRIB32.85279074
8GRK12.75289955
9PKN22.74894091
10MST42.69105491
11MAP4K22.56027640
12INSRR2.55686071
13BMPR1B2.35631352
14NUAK12.29963583
15TAOK32.23428532
16TLK12.23258146
17ZAK2.05213479
18KDR1.99273933
19WNK31.85850420
20MAPK151.84747837
21TYK21.74831641
22MAP2K31.68895591
23PIK3CG1.66998412
24TXK1.66695966
25PHKG11.65710423
26PHKG21.65710423
27NME21.59514151
28TGFBR21.59225899
29TBK11.56722919
30DAPK21.55779085
31EPHB11.53643774
32MAP3K31.47451600
33TIE11.40106179
34OXSR11.37432389
35NEK91.36287010
36PTK61.35892269
37MST1R1.32820112
38MKNK21.31965490
39ERBB31.30391092
40KIT1.26841515
41FRK1.25931030
42STK391.24701269
43JAK31.22107724
44RIPK11.19268811
45PAK31.19104384
46PLK21.18174553
47JAK11.16388752
48TTN1.14738980
49JAK21.14283406
50PTK2B1.12342248
51TGFBR11.09363581
52LRRK21.08895053
53ADRBK11.07831692
54MYLK1.06862290
55EPHA31.06574490
56PRKCE1.03768149
57TRIM281.03316300
58MAP2K61.02524900
59MAPK131.00549129
60ACVR1B0.99044212
61MAP3K100.98944752
62FER0.98918644
63STK240.98313432
64GRK70.96299858
65MAPK110.95586443
66PBK0.94305635
67ABL20.92900676
68CSNK1G10.92042140
69MET0.91732772
70ZAP700.91309881
71CSNK1G30.90607661
72IRAK30.90151482
73ERBB40.89661878
74CSNK1G20.89071852
75MAP3K120.87907318
76MAP4K10.86805433
77DYRK1B0.85991360
78CSF1R0.85603241
79PDK40.85554687
80PDK30.85554687
81STK30.85108695
82BMPR20.84220459
83SCYL20.79565400
84PNCK0.79403625
85MUSK0.77309848
86RPS6KA40.76092812
87BTK0.74963085
88PLK30.72305649
89BRSK20.72120957
90NLK0.71493068
91AKT30.71025533
92LIMK10.70319536
93PRKAA20.70165013
94CSK0.69842284
95PIK3CA0.68415089
96PRKCG0.68004175
97LATS10.67216085
98RPS6KB20.66942923
99CASK0.66503731
100ITK0.66093660
101IKBKE0.65908239
102CAMKK20.65192508
103MAP3K40.63418392
104OBSCN0.63235254
105STK100.63204593
106TEC0.62619707
107PRKCI0.61586678
108PRKCQ0.61567457
109TNIK0.61266196
110CDK60.60832553
111GSK3A0.60673680
112CAMK1D0.60657885
113MAPKAPK30.59198477
114VRK10.58735763
115CSNK1A1L0.56169519
116VRK20.56043454
117MAPKAPK50.52796408
118RPS6KA50.52157792
119PASK0.52127035
120STK38L0.51090953
121PDK20.50600158
122IKBKB0.50128085
123EIF2AK10.49979087
124PDPK10.49234261
125MKNK10.48703514
126PINK10.47906224
127PTK20.47337240
128MAP3K110.47149998
129CAMK2D0.46992183
130PIM10.46429470
131IRAK10.45253310
132MAPK120.44788758
133NTRK30.44398496
134MAP3K70.43551286
135FGFR20.41729229
136MAPK40.41356129
137PRKD30.41028989
138WNK40.40759879
139MAP2K20.40452712
140MAP3K140.40223935
141MELK0.38669396
142STK160.38378213
143EIF2AK30.38223024
144ABL10.38165890
145STK110.37968661
146PDK10.37691013
147MARK30.37371078
148GRK60.37308858
149CAMK2A0.36829511
150MTOR0.36502822
151IGF1R0.34518977
152PDGFRA0.34067550
153HIPK20.34035159
154PRKACG0.32840853
155FGFR30.32789454
156SYK0.32519481
157PRKACA0.32471039
158PRKCA0.32413745
159RET0.32413414
160MAP3K50.31268637
161PRKD10.31080585
162STK40.31036499
163TRPM70.31018620
164GRK50.30930370
165TNK20.30510162
166MAP2K10.30475168
167CSNK1A10.29664423
168CHUK0.28759183

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.11614347
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.07990288
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95276697
4Nitrogen metabolism_Homo sapiens_hsa009102.87105696
5Fatty acid degradation_Homo sapiens_hsa000712.71362900
6Oxidative phosphorylation_Homo sapiens_hsa001902.67167328
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.64424318
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64418092
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56164949
10Tryptophan metabolism_Homo sapiens_hsa003802.53207928
11Arginine biosynthesis_Homo sapiens_hsa002202.48084605
12Complement and coagulation cascades_Homo sapiens_hsa046102.42857486
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.37885595
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37625933
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.34660840
16Propanoate metabolism_Homo sapiens_hsa006402.23850966
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.19831227
18Peroxisome_Homo sapiens_hsa041462.12814199
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01240710
20Butanoate metabolism_Homo sapiens_hsa006501.99536942
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.95482099
22Fatty acid metabolism_Homo sapiens_hsa012121.94252694
23Caffeine metabolism_Homo sapiens_hsa002321.92882096
24Phototransduction_Homo sapiens_hsa047441.86795646
25Sulfur metabolism_Homo sapiens_hsa009201.84551816
26Selenocompound metabolism_Homo sapiens_hsa004501.81382441
27PPAR signaling pathway_Homo sapiens_hsa033201.80145639
28Histidine metabolism_Homo sapiens_hsa003401.79446432
29Chemical carcinogenesis_Homo sapiens_hsa052041.79112447
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76740169
31Parkinsons disease_Homo sapiens_hsa050121.76471506
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74662326
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.72319533
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.70313848
35Type I diabetes mellitus_Homo sapiens_hsa049401.69251071
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.67131189
37Collecting duct acid secretion_Homo sapiens_hsa049661.66687552
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65602832
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.61599774
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.61430865
41Fatty acid elongation_Homo sapiens_hsa000621.60004675
42Folate biosynthesis_Homo sapiens_hsa007901.58187989
43Staphylococcus aureus infection_Homo sapiens_hsa051501.57662314
44beta-Alanine metabolism_Homo sapiens_hsa004101.56761150
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.53558914
46Pyruvate metabolism_Homo sapiens_hsa006201.50871800
47Starch and sucrose metabolism_Homo sapiens_hsa005001.48496455
48Retinol metabolism_Homo sapiens_hsa008301.44900293
49Ether lipid metabolism_Homo sapiens_hsa005651.44718189
50Phenylalanine metabolism_Homo sapiens_hsa003601.41998557
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40756325
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38715593
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35401041
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.34375599
55Carbon metabolism_Homo sapiens_hsa012001.34179436
56RNA polymerase_Homo sapiens_hsa030201.33257103
57Intestinal immune network for IgA production_Homo sapiens_hsa046721.30842607
58Tyrosine metabolism_Homo sapiens_hsa003501.29301113
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27947231
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.27748284
61ABC transporters_Homo sapiens_hsa020101.24281745
62Biosynthesis of amino acids_Homo sapiens_hsa012301.21815067
63Alzheimers disease_Homo sapiens_hsa050101.21459087
64Cysteine and methionine metabolism_Homo sapiens_hsa002701.20218076
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.19171559
66Rheumatoid arthritis_Homo sapiens_hsa053231.18356441
67Fat digestion and absorption_Homo sapiens_hsa049751.17784909
68Insulin secretion_Homo sapiens_hsa049111.17539107
69Homologous recombination_Homo sapiens_hsa034401.15271812
70Proteasome_Homo sapiens_hsa030501.15187719
71Asthma_Homo sapiens_hsa053101.10980426
72Bile secretion_Homo sapiens_hsa049761.10103841
73Basal transcription factors_Homo sapiens_hsa030221.09593713
74Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.98880830
75Arginine and proline metabolism_Homo sapiens_hsa003300.98768859
76Steroid biosynthesis_Homo sapiens_hsa001000.96275817
77Circadian rhythm_Homo sapiens_hsa047100.95517949
78Sphingolipid metabolism_Homo sapiens_hsa006000.94111484
79Pentose phosphate pathway_Homo sapiens_hsa000300.92482907
80Glutathione metabolism_Homo sapiens_hsa004800.92366747
81Sulfur relay system_Homo sapiens_hsa041220.92259450
82Huntingtons disease_Homo sapiens_hsa050160.89549612
83RNA degradation_Homo sapiens_hsa030180.85807099
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85539198
85Mineral absorption_Homo sapiens_hsa049780.84687399
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83810393
87Vitamin digestion and absorption_Homo sapiens_hsa049770.82947318
88Cardiac muscle contraction_Homo sapiens_hsa042600.82543273
89Vitamin B6 metabolism_Homo sapiens_hsa007500.73899720
90Lysine degradation_Homo sapiens_hsa003100.73857958
91Olfactory transduction_Homo sapiens_hsa047400.73845135
92Purine metabolism_Homo sapiens_hsa002300.73362394
93One carbon pool by folate_Homo sapiens_hsa006700.71695594
94Serotonergic synapse_Homo sapiens_hsa047260.70898221
95Ovarian steroidogenesis_Homo sapiens_hsa049130.70390503
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.68235119
97Protein export_Homo sapiens_hsa030600.68001459
98Fanconi anemia pathway_Homo sapiens_hsa034600.67051873
99Glycerolipid metabolism_Homo sapiens_hsa005610.65797935
100Allograft rejection_Homo sapiens_hsa053300.64721197
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.64177812
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63897076
103Graft-versus-host disease_Homo sapiens_hsa053320.58148467
104Galactose metabolism_Homo sapiens_hsa000520.56819556
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56389250
106Metabolic pathways_Homo sapiens_hsa011000.54073147
107Autoimmune thyroid disease_Homo sapiens_hsa053200.52212778
108Morphine addiction_Homo sapiens_hsa050320.50892659
109Circadian entrainment_Homo sapiens_hsa047130.50189924
110Salivary secretion_Homo sapiens_hsa049700.49690143
111Dorso-ventral axis formation_Homo sapiens_hsa043200.48086981
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47571841
113Insulin resistance_Homo sapiens_hsa049310.46561702
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.46330533
115Taste transduction_Homo sapiens_hsa047420.45422368
116Fructose and mannose metabolism_Homo sapiens_hsa000510.44793259
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44176860
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43926779
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.43273285
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.42541920
121Renin secretion_Homo sapiens_hsa049240.40721548
122Pyrimidine metabolism_Homo sapiens_hsa002400.39760829
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39418343
124Nicotine addiction_Homo sapiens_hsa050330.38255602
125GABAergic synapse_Homo sapiens_hsa047270.33402829
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32028790
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31932015
128Fatty acid biosynthesis_Homo sapiens_hsa000610.28714170
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25371711
130Prion diseases_Homo sapiens_hsa050200.20704553
131Linoleic acid metabolism_Homo sapiens_hsa005910.20351304
132Lysosome_Homo sapiens_hsa041420.15645022
133AMPK signaling pathway_Homo sapiens_hsa041520.14686270
134Glucagon signaling pathway_Homo sapiens_hsa049220.12489927
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.09820279
136Legionellosis_Homo sapiens_hsa051340.07232627
137N-Glycan biosynthesis_Homo sapiens_hsa005100.06264396
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.05218897
139Regulation of autophagy_Homo sapiens_hsa041400.04263244
140Other glycan degradation_Homo sapiens_hsa005110.01552214
141Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1127761
142Hepatitis C_Homo sapiens_hsa05160-0.1045083
143Pertussis_Homo sapiens_hsa05133-0.0897641
144Amoebiasis_Homo sapiens_hsa05146-0.0845980
145Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0719282
146Insulin signaling pathway_Homo sapiens_hsa04910-0.0525010
147Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0463646
148Protein digestion and absorption_Homo sapiens_hsa04974-0.0294967
149Malaria_Homo sapiens_hsa05144-0.0291202
150Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0200635
151Renin-angiotensin system_Homo sapiens_hsa04614-0.0088310

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