AAK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.20894442
2synaptic vesicle maturation (GO:0016188)5.82890551
3locomotory exploration behavior (GO:0035641)5.73225124
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.56306046
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.43209380
6synaptic vesicle exocytosis (GO:0016079)5.21006075
7vocalization behavior (GO:0071625)5.12263187
8synaptic vesicle docking involved in exocytosis (GO:0016081)5.07869395
9glutamate secretion (GO:0014047)5.02300644
10regulation of synaptic vesicle exocytosis (GO:2000300)4.82826633
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.80895109
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.69893056
13regulation of glutamate receptor signaling pathway (GO:1900449)4.59484067
14neuronal action potential propagation (GO:0019227)4.46377189
15cellular potassium ion homeostasis (GO:0030007)4.41253569
16neurotransmitter secretion (GO:0007269)4.37821647
17regulation of synaptic vesicle transport (GO:1902803)4.32813777
18protein localization to synapse (GO:0035418)4.31865469
19exploration behavior (GO:0035640)4.24154462
20sodium ion export (GO:0071436)4.22962164
21synaptic transmission, glutamatergic (GO:0035249)4.21671200
22glutamate receptor signaling pathway (GO:0007215)4.20402411
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.17706449
24regulation of neuronal synaptic plasticity (GO:0048168)4.16261926
25cerebellar Purkinje cell differentiation (GO:0021702)4.02789477
26regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00352579
27long-term memory (GO:0007616)3.98737326
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95414295
29neuron-neuron synaptic transmission (GO:0007270)3.94348127
30cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.89144673
31gamma-aminobutyric acid transport (GO:0015812)3.88550349
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84212000
33regulation of synapse structural plasticity (GO:0051823)3.81176748
34layer formation in cerebral cortex (GO:0021819)3.81066087
35regulation of excitatory postsynaptic membrane potential (GO:0060079)3.77675694
36neuron cell-cell adhesion (GO:0007158)3.76950806
37neurotransmitter-gated ion channel clustering (GO:0072578)3.66863996
38positive regulation of membrane potential (GO:0045838)3.66749790
39regulation of postsynaptic membrane potential (GO:0060078)3.65284910
40dendritic spine morphogenesis (GO:0060997)3.61908915
41proline transport (GO:0015824)3.57755909
42cell communication by electrical coupling (GO:0010644)3.57137680
43neurotransmitter transport (GO:0006836)3.51850546
44synaptic vesicle endocytosis (GO:0048488)3.51838352
45positive regulation of synapse maturation (GO:0090129)3.51736757
46activation of protein kinase A activity (GO:0034199)3.46326819
47gamma-aminobutyric acid signaling pathway (GO:0007214)3.44353981
48regulation of synaptic plasticity (GO:0048167)3.42329150
49positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.41746038
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.40237200
51long-term synaptic potentiation (GO:0060291)3.37801543
52membrane depolarization during action potential (GO:0086010)3.34467166
53regulation of ARF protein signal transduction (GO:0032012)3.33431152
54neuromuscular process controlling balance (GO:0050885)3.33398990
55regulation of neurotransmitter secretion (GO:0046928)3.32095685
56neuromuscular process controlling posture (GO:0050884)3.31635514
57regulation of dendritic spine morphogenesis (GO:0061001)3.22301176
58regulation of neurotransmitter levels (GO:0001505)3.21534111
59transmission of nerve impulse (GO:0019226)3.21135877
60membrane hyperpolarization (GO:0060081)3.19997169
61regulation of synaptic transmission, glutamatergic (GO:0051966)3.18148322
62innervation (GO:0060384)3.17789005
63regulation of vesicle fusion (GO:0031338)3.15889917
64membrane depolarization (GO:0051899)3.15599293
65cerebellar granule cell differentiation (GO:0021707)3.15308232
66potassium ion import (GO:0010107)3.12759310
67neuron recognition (GO:0008038)3.11855833
68dendrite morphogenesis (GO:0048813)3.11495550
69activated T cell proliferation (GO:0050798)3.09719379
70negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07398652
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.06292906
72chemosensory behavior (GO:0007635)3.06077732
73positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04383449
74regulation of neurotransmitter transport (GO:0051588)3.04350947
75prepulse inhibition (GO:0060134)3.02934072
76regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.02106263
77vesicle transport along microtubule (GO:0047496)3.01899620
78glycine transport (GO:0015816)3.01317752
79response to histamine (GO:0034776)3.01023934
80cellular sodium ion homeostasis (GO:0006883)3.00716570
81positive regulation of neurotransmitter secretion (GO:0001956)3.00104638
82behavioral defense response (GO:0002209)2.99974791
83behavioral fear response (GO:0001662)2.99974791
84regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99905576
85establishment of protein localization to Golgi (GO:0072600)2.99237206
86positive regulation of neurotransmitter transport (GO:0051590)2.99228433
87axonal fasciculation (GO:0007413)2.98518489
88L-amino acid import (GO:0043092)2.96995220
89regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.96914473
90protein K11-linked deubiquitination (GO:0035871)2.96225041
91positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.95267830
92potassium ion homeostasis (GO:0055075)2.94606452
93regulation of voltage-gated calcium channel activity (GO:1901385)2.93265213
94positive regulation of synaptic transmission, GABAergic (GO:0032230)2.91571317
95establishment of nucleus localization (GO:0040023)2.89989498
96phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.89706969
97long term synaptic depression (GO:0060292)2.89435355
98G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.87654602
99positive regulation of synaptic transmission (GO:0050806)2.87464561
100neuromuscular process (GO:0050905)2.86041940
101synaptic transmission (GO:0007268)2.84853374
102learning (GO:0007612)2.84438226
103fear response (GO:0042596)2.84025567
104response to auditory stimulus (GO:0010996)2.83295289
105positive regulation of potassium ion transmembrane transport (GO:1901381)2.82501211
106auditory behavior (GO:0031223)2.82156624
107serotonin metabolic process (GO:0042428)2.81748485
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.77395114
109negative regulation of translation, ncRNA-mediated (GO:0040033)2.77395114
110regulation of translation, ncRNA-mediated (GO:0045974)2.77395114
111cAMP catabolic process (GO:0006198)2.74236044
112phospholipid translocation (GO:0045332)2.73948775
113lipid translocation (GO:0034204)2.73948775
114cyclic nucleotide catabolic process (GO:0009214)2.69531570
115primary amino compound metabolic process (GO:1901160)2.67670625
116detection of calcium ion (GO:0005513)2.66661744
117histone H3-K4 trimethylation (GO:0080182)2.64274978
118cell differentiation in hindbrain (GO:0021533)2.63782868
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62691814
120neuronal action potential (GO:0019228)2.60990005
121negative regulation of neurotransmitter transport (GO:0051589)2.57880285
122startle response (GO:0001964)2.57745454
123urinary tract smooth muscle contraction (GO:0014848)2.56807704
124protein targeting to Golgi (GO:0000042)2.50835734
125interkinetic nuclear migration (GO:0022027)2.50552187
126cellular response to ethanol (GO:0071361)2.49408618
127negative T cell selection (GO:0043383)2.49132103
128behavioral response to nicotine (GO:0035095)2.40421051
129retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38216401
130postsynaptic membrane organization (GO:0001941)2.37649073
131protein K48-linked deubiquitination (GO:0071108)2.35233131
132cytoplasmic mRNA processing body assembly (GO:0033962)2.33673010
133macroautophagy (GO:0016236)2.33099805
134pericardium development (GO:0060039)2.32578326
135positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.27922237
136positive regulation of CREB transcription factor activity (GO:0032793)2.27596601
137presynaptic membrane assembly (GO:0097105)2.26743058
138regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26721901
139positive T cell selection (GO:0043368)2.26656891
140negative thymic T cell selection (GO:0045060)2.26580745
141nerve growth factor signaling pathway (GO:0038180)2.22148387
142nucleus localization (GO:0051647)2.18136977
143relaxation of cardiac muscle (GO:0055119)2.17145906
144positive regulation of Rap GTPase activity (GO:0032854)2.15699565
145regulation of sodium ion transmembrane transporter activity (GO:2000649)2.13846535
146potassium ion transmembrane transport (GO:0071805)2.13040217

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.68324034
2GBX2_23144817_ChIP-Seq_PC3_Human3.37032629
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.91869604
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.89112786
5DROSHA_22980978_ChIP-Seq_HELA_Human2.82195607
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.78644387
7RARB_27405468_Chip-Seq_BRAIN_Mouse2.57358441
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57324840
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57324840
10REST_21632747_ChIP-Seq_MESCs_Mouse2.53725606
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41589834
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40934025
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.40788853
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.39804472
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.38435480
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35672433
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.29594794
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24833026
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.18280049
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14861926
21IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07036750
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.06383439
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.04643084
24SUZ12_27294783_Chip-Seq_ESCs_Mouse2.04066598
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.02303293
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01476516
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.01086818
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86789747
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.84878483
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84846139
31AR_21572438_ChIP-Seq_LNCaP_Human1.84657860
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.82449742
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78842154
34SMAD4_21799915_ChIP-Seq_A2780_Human1.70505778
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.59070252
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57459109
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.53653649
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51558716
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49898232
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45227503
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.43989511
42RUNX_20019798_ChIP-Seq_JUKART_Human1.43780987
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.41680260
44AR_19668381_ChIP-Seq_PC3_Human1.35667254
45* SOX2_21211035_ChIP-Seq_LN229_Gbm1.34326210
46ERG_21242973_ChIP-ChIP_JURKAT_Human1.34113187
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.33734000
48VDR_22108803_ChIP-Seq_LS180_Human1.32951824
49* STAT3_23295773_ChIP-Seq_U87_Human1.31728287
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29533127
51ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29279334
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29090140
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28455034
54WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28033669
55ZNF274_21170338_ChIP-Seq_K562_Hela1.27273284
56TAF15_26573619_Chip-Seq_HEK293_Human1.26401390
57AR_25329375_ChIP-Seq_VCAP_Human1.23371541
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.22914414
59P300_19829295_ChIP-Seq_ESCs_Human1.22344990
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.22143082
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21332279
62RING1B_27294783_Chip-Seq_ESCs_Mouse1.21290366
63ER_23166858_ChIP-Seq_MCF-7_Human1.20861781
64TP53_16413492_ChIP-PET_HCT116_Human1.20751771
65KDM2B_26808549_Chip-Seq_K562_Human1.19544961
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19399300
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18942936
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.17430987
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16777927
70RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.16583582
71TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16375078
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.16076753
73AHR_22903824_ChIP-Seq_MCF-7_Human1.15707031
74TCF4_23295773_ChIP-Seq_U87_Human1.15517466
75DNAJC2_21179169_ChIP-ChIP_NT2_Human1.15459641
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14877883
77TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14813867
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.14138498
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.14119405
80NANOG_18555785_Chip-Seq_ESCs_Mouse1.13594818
81FLI1_21867929_ChIP-Seq_TH2_Mouse1.13252141
82BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13091702
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12821448
84KDM2B_26808549_Chip-Seq_REH_Human1.10286964
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09301424
86RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09285439
87EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09261934
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08807334
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08296763
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06762475
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06616976
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06541307
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06169214
94GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05939552
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.05560883
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.04049426
97CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03716127
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.03004987
99TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.02566644
100EP300_21415370_ChIP-Seq_HL-1_Mouse1.02173644
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.01685790
102RXR_22108803_ChIP-Seq_LS180_Human1.00434450
103TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99876250
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99806988
105CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99688449
106TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99556174
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.99337715
108E2F1_18555785_Chip-Seq_ESCs_Mouse0.98960388
109IGF1R_20145208_ChIP-Seq_DFB_Human0.98934003
110SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98703112
111P53_22387025_ChIP-Seq_ESCs_Mouse0.98457319
112* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98271064
113EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97909220
114NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97380497
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97137643
116ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97066167
117SMAD3_21741376_ChIP-Seq_ESCs_Human0.96819632
118DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95889847
119RUNX2_22187159_ChIP-Seq_PCA_Human0.93448773
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.93363628
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.92534244
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90193050
123POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89860112
124BCAT_22108803_ChIP-Seq_LS180_Human0.89569708
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89417865
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89020728
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88487480
128POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88487480
129ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87051696

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.85707669
2MP0003880_abnormal_central_pattern4.36775929
3MP0003635_abnormal_synaptic_transmissio4.25055174
4MP0004270_analgesia3.55278699
5MP0009046_muscle_twitch3.42155081
6MP0009745_abnormal_behavioral_response3.39824416
7MP0002063_abnormal_learning/memory/cond3.27357699
8MP0002064_seizures3.24459068
9MP0005423_abnormal_somatic_nervous2.85274666
10MP0001968_abnormal_touch/_nociception2.82747925
11MP0002572_abnormal_emotion/affect_behav2.77334227
12MP0002272_abnormal_nervous_system2.65523494
13MP0001486_abnormal_startle_reflex2.55960779
14MP0002822_catalepsy2.53802483
15MP0002734_abnormal_mechanical_nocicepti2.48855902
16MP0001501_abnormal_sleep_pattern2.34469624
17MP0008569_lethality_at_weaning2.28750735
18MP0004130_abnormal_muscle_cell2.18246570
19MP0009780_abnormal_chondrocyte_physiolo2.17299959
20MP0002735_abnormal_chemical_nociception2.05046165
21MP0002067_abnormal_sensory_capabilities2.03252063
22MP0002736_abnormal_nociception_after2.01617038
23MP0001440_abnormal_grooming_behavior1.99576565
24MP0002909_abnormal_adrenal_gland1.85007270
25MP0001970_abnormal_pain_threshold1.78959811
26MP0000569_abnormal_digit_pigmentation1.78941954
27MP0002733_abnormal_thermal_nociception1.78367468
28MP0002184_abnormal_innervation1.74474460
29MP0004811_abnormal_neuron_physiology1.73674481
30MP0004924_abnormal_behavior1.70588695
31MP0005386_behavior/neurological_phenoty1.70588695
32MP0003787_abnormal_imprinting1.67590661
33MP0002557_abnormal_social/conspecific_i1.67515513
34MP0008877_abnormal_DNA_methylation1.66040270
35MP0004858_abnormal_nervous_system1.65210884
36MP0005551_abnormal_eye_electrophysiolog1.64219501
37MP0003329_amyloid_beta_deposits1.61567468
38MP0004885_abnormal_endolymph1.55251177
39MP0003879_abnormal_hair_cell1.54639447
40MP0005646_abnormal_pituitary_gland1.51180862
41MP0000778_abnormal_nervous_system1.50552367
42MP0001986_abnormal_taste_sensitivity1.49439645
43MP0000427_abnormal_hair_cycle1.47627618
44MP0005174_abnormal_tail_pigmentation1.47495324
45MP0001984_abnormal_olfaction1.45602864
46MP0000955_abnormal_spinal_cord1.44983849
47MP0000015_abnormal_ear_pigmentation1.44865094
48MP0002882_abnormal_neuron_morphology1.44161480
49MP0003633_abnormal_nervous_system1.43815508
50MP0001502_abnormal_circadian_rhythm1.40022493
51MP0004145_abnormal_muscle_electrophysio1.38145249
52MP0002066_abnormal_motor_capabilities/c1.37971111
53MP0002876_abnormal_thyroid_physiology1.35535167
54MP0003763_abnormal_thymus_physiology1.32896966
55MP0000751_myopathy1.21854373
56MP0003122_maternal_imprinting1.19903513
57MP0008961_abnormal_basal_metabolism1.19634796
58MP0003646_muscle_fatigue1.17963681
59MP0003631_nervous_system_phenotype1.17380985
60MP0002229_neurodegeneration1.13621404
61MP0003195_calcinosis1.13045319
62MP0004142_abnormal_muscle_tone1.10176279
63MP0006276_abnormal_autonomic_nervous1.09987260
64MP0005645_abnormal_hypothalamus_physiol1.09122024
65MP0002928_abnormal_bile_duct1.07654909
66MP0004215_abnormal_myocardial_fiber1.07372816
67MP0002152_abnormal_brain_morphology1.06855228
68MP0008057_abnormal_DNA_replication1.02592425
69MP0005310_abnormal_salivary_gland0.99895785
70MP0004233_abnormal_muscle_weight0.98651441
71MP0004084_abnormal_cardiac_muscle0.96687393
72MP0004085_abnormal_heartbeat0.96663366
73MP0002090_abnormal_vision0.94168553
74MP0003283_abnormal_digestive_organ0.94152203
75MP0003045_fibrosis0.93774029
76MP0000013_abnormal_adipose_tissue0.93206880
77MP0004510_myositis0.92537700
78MP0008872_abnormal_physiological_respon0.91252213
79MP0008874_decreased_physiological_sensi0.90796246
80MP0001177_atelectasis0.90547231
81MP0001188_hyperpigmentation0.89593783
82MP0002069_abnormal_eating/drinking_beha0.88677107
83MP0006072_abnormal_retinal_apoptosis0.85181700
84MP0004484_altered_response_of0.84311666
85MP0003632_abnormal_nervous_system0.84019539
86MP0002837_dystrophic_cardiac_calcinosis0.83028289
87MP0003690_abnormal_glial_cell0.80873962
88MP0002168_other_aberrant_phenotype0.80820723
89MP0004742_abnormal_vestibular_system0.80381395
90MP0001348_abnormal_lacrimal_gland0.80372121
91MP0005253_abnormal_eye_physiology0.80030073
92MP0010386_abnormal_urinary_bladder0.80029021
93MP0001299_abnormal_eye_distance/0.79949905
94MP0003634_abnormal_glial_cell0.79042972
95MP0010234_abnormal_vibrissa_follicle0.77906612
96MP0002009_preneoplasia0.76351052
97MP0005623_abnormal_meninges_morphology0.76161020
98MP0004134_abnormal_chest_morphology0.75887369
99MP0003075_altered_response_to0.75568855
100MP0005535_abnormal_body_temperature0.75161009
101MP0002752_abnormal_somatic_nervous0.75090068
102MP0003172_abnormal_lysosome_physiology0.74828266
103MP0001765_abnormal_ion_homeostasis0.73206427
104MP0003137_abnormal_impulse_conducting0.72600908
105MP0005448_abnormal_energy_balance0.72563668
106MP0001905_abnormal_dopamine_level0.72262460
107MP0000920_abnormal_myelination0.71960711
108MP0001963_abnormal_hearing_physiology0.70232831
109MP0003724_increased_susceptibility_to0.69501045
110MP0004043_abnormal_pH_regulation0.68243264
111MP0000230_abnormal_systemic_arterial0.68089546
112MP0005499_abnormal_olfactory_system0.67591978
113MP0005394_taste/olfaction_phenotype0.67591978
114MP0005671_abnormal_response_to0.64694739
115MP0000604_amyloidosis0.64625661
116MP0004036_abnormal_muscle_relaxation0.63612182
117MP0004381_abnormal_hair_follicle0.62786425
118MP0002693_abnormal_pancreas_physiology0.62404930
119MP0005187_abnormal_penis_morphology0.60349530
120MP0001529_abnormal_vocalization0.59886406
121MP0000631_abnormal_neuroendocrine_gland0.59122817
122MP0002638_abnormal_pupillary_reflex0.58315184
123MP0010769_abnormal_survival0.57673848
124MP0005167_abnormal_blood-brain_barrier0.56873694
125MP0001943_abnormal_respiration0.55500220
126MP0001485_abnormal_pinna_reflex0.54306967

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.32328069
2Myokymia (HP:0002411)5.97280225
3Focal seizures (HP:0007359)5.71064289
4Visual hallucinations (HP:0002367)5.10995658
5Progressive cerebellar ataxia (HP:0002073)4.77927671
6Epileptic encephalopathy (HP:0200134)4.77169153
7Febrile seizures (HP:0002373)4.73898858
8Action tremor (HP:0002345)4.43704700
9Atonic seizures (HP:0010819)4.42551878
10Absence seizures (HP:0002121)4.12006039
11Gaze-evoked nystagmus (HP:0000640)3.81596820
12Dialeptic seizures (HP:0011146)3.69116156
13Generalized tonic-clonic seizures (HP:0002069)3.66769913
14Broad-based gait (HP:0002136)3.55887360
15Dysdiadochokinesis (HP:0002075)3.49937152
16Genetic anticipation (HP:0003743)3.46879303
17Truncal ataxia (HP:0002078)3.32783411
18Poor eye contact (HP:0000817)3.29025063
19Dysmetric saccades (HP:0000641)3.25855495
20Depression (HP:0000716)3.20251322
21Supranuclear gaze palsy (HP:0000605)3.18948224
22Impaired social interactions (HP:0000735)3.16008353
23Abnormal social behavior (HP:0012433)3.16008353
24Impaired smooth pursuit (HP:0007772)3.15717889
25Dysmetria (HP:0001310)3.12939366
26Impaired vibration sensation in the lower limbs (HP:0002166)3.09757768
27Postural instability (HP:0002172)3.01251807
28Hemiplegia (HP:0002301)3.00149390
29Urinary bladder sphincter dysfunction (HP:0002839)2.99113491
30Scanning speech (HP:0002168)2.95043739
31Clumsiness (HP:0002312)2.87308087
32Ankle clonus (HP:0011448)2.85323182
33Abnormality of ocular smooth pursuit (HP:0000617)2.82008184
34Hyperventilation (HP:0002883)2.80229981
35Widely spaced teeth (HP:0000687)2.79141734
36Fair hair (HP:0002286)2.78995873
37Papilledema (HP:0001085)2.74565970
38Generalized hypopigmentation of hair (HP:0011358)2.74423439
39Anxiety (HP:0000739)2.68747835
40Abnormality of the lower motor neuron (HP:0002366)2.68452690
41Drooling (HP:0002307)2.60509184
42Excessive salivation (HP:0003781)2.60509184
43Intention tremor (HP:0002080)2.57060316
44Abnormal eating behavior (HP:0100738)2.56276182
45Hemiparesis (HP:0001269)2.54941450
46Diplopia (HP:0000651)2.53024967
47Abnormality of binocular vision (HP:0011514)2.53024967
48Ventricular fibrillation (HP:0001663)2.52677601
49Central scotoma (HP:0000603)2.47626123
50Inability to walk (HP:0002540)2.47063277
51Amblyopia (HP:0000646)2.46819253
52Stereotypic behavior (HP:0000733)2.46111039
53Urinary urgency (HP:0000012)2.42944971
54T lymphocytopenia (HP:0005403)2.42608611
55Mutism (HP:0002300)2.41909498
56Status epilepticus (HP:0002133)2.34266996
57Abnormality of T cell number (HP:0011839)2.29705602
58Epileptiform EEG discharges (HP:0011182)2.28193558
59Pointed chin (HP:0000307)2.24907027
60Bradykinesia (HP:0002067)2.24618698
61Spastic gait (HP:0002064)2.24193819
62Absent speech (HP:0001344)2.23023113
63Bundle branch block (HP:0011710)2.22393531
64Congenital stationary night blindness (HP:0007642)2.17862298
65Torticollis (HP:0000473)2.17795825
66EEG with generalized epileptiform discharges (HP:0011198)2.17779802
67Impaired vibratory sensation (HP:0002495)2.16915787
68Annular pancreas (HP:0001734)2.16869264
69Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15168076
70Thyroiditis (HP:0100646)2.10473281
71Macroorchidism (HP:0000053)2.08844807
72Abnormality of the renal cortex (HP:0011035)2.03182548
73Hypsarrhythmia (HP:0002521)2.03047895
74Insomnia (HP:0100785)2.01496067
75Progressive inability to walk (HP:0002505)2.00054619
76Macroglossia (HP:0000158)1.99952382
77Agitation (HP:0000713)1.99914263
78Abnormal EKG (HP:0003115)1.97887486
79Focal dystonia (HP:0004373)1.97144306
80Termporal pattern (HP:0011008)1.96803046
81Insidious onset (HP:0003587)1.96803046
82Prolonged QT interval (HP:0001657)1.96023296
83Abnormality of saccadic eye movements (HP:0000570)1.95413880
84Megalencephaly (HP:0001355)1.94448187
85Attenuation of retinal blood vessels (HP:0007843)1.93534354
86Gait ataxia (HP:0002066)1.92246622
87Abnormality of macular pigmentation (HP:0008002)1.91730750
88Narrow palate (HP:0000189)1.90652379
89Pancreatic cysts (HP:0001737)1.89259748
90Short chin (HP:0000331)1.87827613
91Lower limb muscle weakness (HP:0007340)1.87220397
92Bulbous nose (HP:0000414)1.86623610
93Abnormality of the fingertips (HP:0001211)1.86548397
94Neoplasm of the heart (HP:0100544)1.85237970
95Blue irides (HP:0000635)1.85159884
96Decreased circulating renin level (HP:0003351)1.84802053
97Slow saccadic eye movements (HP:0000514)1.84767982
98Ocular albinism (HP:0001107)1.84734040
99Neonatal hypoglycemia (HP:0001998)1.84703314
100Stomach cancer (HP:0012126)1.84189224
101Limb dystonia (HP:0002451)1.83163255
102Pheochromocytoma (HP:0002666)1.82440727
103Aqueductal stenosis (HP:0002410)1.81601610
104Atrial fibrillation (HP:0005110)1.81221168
105Lower limb asymmetry (HP:0100559)1.81087702
106Exotropia (HP:0000577)1.80165474
107Postural tremor (HP:0002174)1.78820232
108Tented upper lip vermilion (HP:0010804)1.78781856
109Fetal akinesia sequence (HP:0001989)1.78557534
110Lower limb amyotrophy (HP:0007210)1.77602829
111Hematochezia (HP:0002573)1.77429362
112Neuronal loss in central nervous system (HP:0002529)1.77049046
113Inappropriate behavior (HP:0000719)1.76154580
114Generalized myoclonic seizures (HP:0002123)1.75599338
115Syncope (HP:0001279)1.75438888
116Incomplete penetrance (HP:0003829)1.75329495
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74652422
118Scotoma (HP:0000575)1.74605095
119Cerebral inclusion bodies (HP:0100314)1.73803765
120Primary atrial arrhythmia (HP:0001692)1.73755718
121Abnormal drinking behavior (HP:0030082)1.73697932
122Polydipsia (HP:0001959)1.73697932
123Type II lissencephaly (HP:0007260)1.73553879
124Abnormality of the corticospinal tract (HP:0002492)1.72734253
125Hypoventilation (HP:0002791)1.72727786
126Spinal canal stenosis (HP:0003416)1.71848052
127Obstructive sleep apnea (HP:0002870)1.71655967
128Nephronophthisis (HP:0000090)1.71047919
129Abnormality of the nasal septum (HP:0000419)1.69627282
130Psychosis (HP:0000709)1.68714915
131Tapered finger (HP:0001182)1.67952537
132Abnormality of the renal medulla (HP:0100957)1.67949515
133Molar tooth sign on MRI (HP:0002419)1.66102108
134Abnormality of midbrain morphology (HP:0002418)1.66102108
135Craniofacial dystonia (HP:0012179)1.65906482
136Resting tremor (HP:0002322)1.65885943
137Protruding tongue (HP:0010808)1.65872594
138Stomatitis (HP:0010280)1.62959781
139Dyskinesia (HP:0100660)1.61680565
140Iris hypopigmentation (HP:0007730)1.60094376
141Abnormality of the columella (HP:0009929)1.58157018
142Chronic hepatic failure (HP:0100626)1.56775046
143Pancreatic fibrosis (HP:0100732)1.54774101
144Intellectual disability, severe (HP:0010864)1.54211961

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.32377302
2NTRK34.93974897
3EPHA43.85260957
4MAP3K93.69690666
5MAP3K43.08127020
6TAOK32.55781776
7MINK12.42183512
8DAPK22.40735236
9PAK62.34391689
10MAP2K72.30147008
11MARK12.23346157
12PRKD32.14781355
13CAMKK12.09757953
14NTRK22.07141580
15KSR22.02367695
16TNIK1.91065776
17RIPK41.89862876
18MAP2K41.82549323
19NTRK11.58327803
20KSR11.53020178
21PRPF4B1.51299344
22CDK51.49227665
23SIK21.48153292
24CAMKK21.45841134
25TXK1.45474192
26DAPK11.43112464
27MAP3K121.35936038
28PNCK1.33997614
29ACVR1B1.32611405
30MAP3K131.28796933
31PRKCH1.23427728
32MAP3K21.22547910
33PLK21.21539798
34FES1.21244666
35TYRO31.18445156
36SGK21.17400257
37PRKCG1.15534214
38SGK31.15523437
39CAMK1G1.14538601
40CAMK11.13958317
41NLK1.13529844
42ADRBK21.13405876
43JAK11.12927100
44RIPK11.12817034
45CASK1.11645277
46SGK4941.10581253
47SGK2231.10581253
48TAOK11.10451748
49MAPK131.08716474
50GRK51.08192950
51CDK191.05738713
52BMPR1B1.03944453
53PIK3CA1.03456895
54STK111.02898591
55WNK11.02439774
56TRPM70.99770432
57RET0.96888550
58CAMK2A0.93320028
59UHMK10.92880631
60ITK0.92843125
61MAP3K70.89370107
62FGFR30.87850526
63CDK120.87844890
64SGK10.87414201
65PHKG10.87103747
66PHKG20.87103747
67LMTK20.84526963
68STK390.84205029
69ALK0.84196565
70PAK30.82502388
71PDK10.82268828
72GRK10.81344938
73CDC42BPA0.79340208
74MARK20.79091841
75TEC0.78615398
76DMPK0.75573928
77PTK2B0.75167911
78PINK10.74559865
79CDK180.74521031
80CDK150.74060801
81TNK20.73908713
82* STK380.73520665
83INSRR0.73478634
84WNK40.73107613
85SYK0.72797720
86RAF10.71448599
87CAMK2B0.70465731
88CAMK40.69210708
89PDGFRB0.68363558
90CDK140.68086820
91ARAF0.67894897
92ADRBK10.67672379
93PDPK10.67234597
94MAP3K10.63617368
95DYRK1A0.63600908
96LATS20.63018917
97ZAP700.62640014
98CDK11A0.62251617
99RPS6KA30.60637783
100HIPK20.55655589
101MAPK70.55455372
102CAMK2D0.55437294
103OXSR10.54922233
104MAPK100.53617790
105LCK0.53541698
106MAP4K10.52767206
107NEK60.52650120
108SCYL20.51482842
109FYN0.51373163
110FGFR20.50998819
111BMPR20.50565470
112FER0.49681011
113PIK3CG0.49231070
114PRKCQ0.48924831
115GRK60.46823523
116AKT30.45878416
117IKBKE0.45446003
118CSNK1G20.45177829
119PRKCZ0.43813018
120PRKCE0.43203846
121PRKAA20.42244969
122HCK0.41749311
123PRKAA10.40651255
124LATS10.40277861
125MELK0.39872713
126ERBB20.39587574
127MAP2K10.38795738
128CAMK2G0.38689804
129PDGFRA0.38207976
130WNK30.37449136
131MARK30.37268479
132* PRKCB0.37071562
133MAP4K20.36618940
134CAMK1D0.36151249
135MAPK120.34007073
136PRKD20.33900776
137ROCK20.33857204
138PRKG10.32292196
139NEK10.31993091
140RPS6KA20.30736751

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46890722
2Synaptic vesicle cycle_Homo sapiens_hsa047212.94988399
3Long-term potentiation_Homo sapiens_hsa047202.62856014
4Circadian entrainment_Homo sapiens_hsa047132.61958333
5GABAergic synapse_Homo sapiens_hsa047272.54578820
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52057960
7Glutamatergic synapse_Homo sapiens_hsa047242.50363590
8Olfactory transduction_Homo sapiens_hsa047402.49242044
9Morphine addiction_Homo sapiens_hsa050322.35495940
10Amphetamine addiction_Homo sapiens_hsa050312.28477065
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13616767
12Salivary secretion_Homo sapiens_hsa049702.13242637
13Insulin secretion_Homo sapiens_hsa049112.04480618
14Dopaminergic synapse_Homo sapiens_hsa047281.98978310
15Aldosterone synthesis and secretion_Homo sapiens_hsa049251.88290779
16Gastric acid secretion_Homo sapiens_hsa049711.87339430
17Cholinergic synapse_Homo sapiens_hsa047251.83702685
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69260630
19Taste transduction_Homo sapiens_hsa047421.65706786
20Oxytocin signaling pathway_Homo sapiens_hsa049211.65120363
21Long-term depression_Homo sapiens_hsa047301.64860768
22Renin secretion_Homo sapiens_hsa049241.64205669
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.57418631
24Calcium signaling pathway_Homo sapiens_hsa040201.54436843
25Phototransduction_Homo sapiens_hsa047441.53909805
26Type II diabetes mellitus_Homo sapiens_hsa049301.45038339
27Cocaine addiction_Homo sapiens_hsa050301.44249860
28Serotonergic synapse_Homo sapiens_hsa047261.42212171
29GnRH signaling pathway_Homo sapiens_hsa049121.40899117
30Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.35339299
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34086370
32cAMP signaling pathway_Homo sapiens_hsa040241.32729289
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.24150170
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22249324
35Gap junction_Homo sapiens_hsa045401.21389338
36Glioma_Homo sapiens_hsa052141.17198472
37Estrogen signaling pathway_Homo sapiens_hsa049151.16338791
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16337991
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05738640
40ABC transporters_Homo sapiens_hsa020101.05725748
41Collecting duct acid secretion_Homo sapiens_hsa049661.02889844
42ErbB signaling pathway_Homo sapiens_hsa040121.02358386
43Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01840212
44Dilated cardiomyopathy_Homo sapiens_hsa054140.98920786
45Pancreatic secretion_Homo sapiens_hsa049720.98182791
46Melanogenesis_Homo sapiens_hsa049160.97761127
47Dorso-ventral axis formation_Homo sapiens_hsa043200.96556316
48Nitrogen metabolism_Homo sapiens_hsa009100.95555674
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94855819
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.93002098
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.90660503
52Axon guidance_Homo sapiens_hsa043600.89708042
53Thyroid hormone synthesis_Homo sapiens_hsa049180.87605955
54Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84778373
55Cardiac muscle contraction_Homo sapiens_hsa042600.80954110
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80852022
57Choline metabolism in cancer_Homo sapiens_hsa052310.80764838
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79882935
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77296684
60Ether lipid metabolism_Homo sapiens_hsa005650.77226056
61mTOR signaling pathway_Homo sapiens_hsa041500.77026356
62MAPK signaling pathway_Homo sapiens_hsa040100.76935517
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76159219
64Oocyte meiosis_Homo sapiens_hsa041140.76116166
65FoxO signaling pathway_Homo sapiens_hsa040680.75524170
66Circadian rhythm_Homo sapiens_hsa047100.73246212
67Linoleic acid metabolism_Homo sapiens_hsa005910.71658281
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.71055251
69Regulation of autophagy_Homo sapiens_hsa041400.69685843
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69321395
71VEGF signaling pathway_Homo sapiens_hsa043700.69303362
72Inositol phosphate metabolism_Homo sapiens_hsa005620.67984132
73Glucagon signaling pathway_Homo sapiens_hsa049220.66069726
74Vibrio cholerae infection_Homo sapiens_hsa051100.64044100
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62824519
76Rap1 signaling pathway_Homo sapiens_hsa040150.59463562
77Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59302546
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57669279
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57037038
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.56654049
81Endometrial cancer_Homo sapiens_hsa052130.56630622
82Ras signaling pathway_Homo sapiens_hsa040140.55896428
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54155197
84Non-small cell lung cancer_Homo sapiens_hsa052230.53786771
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52498373
86Endocytosis_Homo sapiens_hsa041440.50964742
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.49990016
88Bile secretion_Homo sapiens_hsa049760.48663483
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47810458
90Osteoclast differentiation_Homo sapiens_hsa043800.47150863
91Insulin signaling pathway_Homo sapiens_hsa049100.47034840
92Insulin resistance_Homo sapiens_hsa049310.46786620
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46749952
94B cell receptor signaling pathway_Homo sapiens_hsa046620.46674513
95Type I diabetes mellitus_Homo sapiens_hsa049400.45977110
96Primary immunodeficiency_Homo sapiens_hsa053400.45752993
97Wnt signaling pathway_Homo sapiens_hsa043100.45727352
98Lysine degradation_Homo sapiens_hsa003100.45118737
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.44722025
100Renal cell carcinoma_Homo sapiens_hsa052110.44084230
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43853807
102Chemokine signaling pathway_Homo sapiens_hsa040620.43630369
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43306896
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42420244
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41612564
106Glycerolipid metabolism_Homo sapiens_hsa005610.41352715
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41235607
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36971438
109Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36807976
110Alcoholism_Homo sapiens_hsa050340.36398747
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35785131
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35767274
113Platelet activation_Homo sapiens_hsa046110.34142176
114Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33930342
115Ovarian steroidogenesis_Homo sapiens_hsa049130.31816537
116Colorectal cancer_Homo sapiens_hsa052100.31146444
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.30855657
118Prolactin signaling pathway_Homo sapiens_hsa049170.29684052
119T cell receptor signaling pathway_Homo sapiens_hsa046600.28496003
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27239059

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