AANAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cellular amide metabolic process (GO:0034250)7.10172788
2cytoplasmic mRNA processing body assembly (GO:0033962)6.16684091
3synaptic vesicle endocytosis (GO:0048488)6.14522948
4negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.79683583
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.67861461
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.67861461
7modulation by symbiont of host immune response (GO:0052553)4.67861461
8positive regulation by symbiont of host defense response (GO:0052509)4.67861461
9modulation by symbiont of host defense response (GO:0052031)4.67861461
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.67861461
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.48920529
12positive regulation of gamma-delta T cell activation (GO:0046645)4.48852461
13positive regulation of type 2 immune response (GO:0002830)4.30128357
14positive regulation of interleukin-17 production (GO:0032740)4.26478035
15response to pheromone (GO:0019236)4.23864161
16interferon-gamma production (GO:0032609)4.13646570
17cellular response to ATP (GO:0071318)4.02555130
18myeloid leukocyte mediated immunity (GO:0002444)3.83896707
19opioid receptor signaling pathway (GO:0038003)3.83695404
20regulation of dendritic cell antigen processing and presentation (GO:0002604)3.83580732
21positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.83005067
22purinergic nucleotide receptor signaling pathway (GO:0035590)3.70963547
23detection of bacterium (GO:0016045)3.69450221
24positive regulation of defense response to virus by host (GO:0002230)3.65797725
25response to host immune response (GO:0052572)3.62710132
26response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.62710132
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.61030376
28detection of other organism (GO:0098543)3.60063828
29positive regulation of p38MAPK cascade (GO:1900745)3.58870414
30regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.58816014
31N-glycan processing (GO:0006491)3.56221413
32neutrophil mediated immunity (GO:0002446)3.53072035
33regulation of activation of Janus kinase activity (GO:0010533)3.49558780
34positive regulation of humoral immune response (GO:0002922)3.48634488
35nephron epithelium morphogenesis (GO:0072088)3.47121529
36nephron tubule morphogenesis (GO:0072078)3.47121529
37positive regulation of interleukin-1 beta secretion (GO:0050718)3.46638251
38piRNA metabolic process (GO:0034587)3.44407539
39regulation of platelet aggregation (GO:0090330)3.38983937
40detection of molecule of bacterial origin (GO:0032490)3.37949419
41pyrimidine-containing compound transmembrane transport (GO:0072531)3.36791173
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33283692
43cellular biogenic amine catabolic process (GO:0042402)3.32770833
44amine catabolic process (GO:0009310)3.32770833
45negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30516204
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30419940
47response to host (GO:0075136)3.30419940
48response to host defenses (GO:0052200)3.30419940
49response to muramyl dipeptide (GO:0032495)3.27793343
50negative regulation of protein oligomerization (GO:0032460)3.27388085
51tryptophan catabolic process (GO:0006569)3.24475100
52indole-containing compound catabolic process (GO:0042436)3.24475100
53indolalkylamine catabolic process (GO:0046218)3.24475100
54response to peptidoglycan (GO:0032494)3.20811374
55nonmotile primary cilium assembly (GO:0035058)3.17206914
56positive regulation of interleukin-1 secretion (GO:0050716)3.17201998
57epithelial cilium movement (GO:0003351)3.17050040
58superoxide anion generation (GO:0042554)3.16995192
59positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.15721740
60regulation of MHC class II biosynthetic process (GO:0045346)3.15241090
61positive regulation of DNA-dependent DNA replication (GO:2000105)3.14073251
62regulation of interleukin-17 production (GO:0032660)3.13736565
63negative regulation of homotypic cell-cell adhesion (GO:0034111)3.13670256
64behavioral response to nicotine (GO:0035095)3.11715297
65regulation of collateral sprouting (GO:0048670)3.07972846
66ganglioside metabolic process (GO:0001573)3.07969098
67platelet dense granule organization (GO:0060155)3.07752682
68regulation of interleukin-1 beta secretion (GO:0050706)3.05127239
69regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.04515127
70microglial cell activation (GO:0001774)3.04495612
71detection of light stimulus involved in sensory perception (GO:0050962)3.04430518
72detection of light stimulus involved in visual perception (GO:0050908)3.04430518
73positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.01036999
74regulation of cellular amide metabolic process (GO:0034248)3.00687709
75regulation of interleukin-8 biosynthetic process (GO:0045414)3.00491841
76tyrosine phosphorylation of STAT protein (GO:0007260)2.99748200
77signal peptide processing (GO:0006465)2.98389039
78regulation of interferon-alpha production (GO:0032647)2.97570894
79regulation of interleukin-6 biosynthetic process (GO:0045408)2.96538878
80response to ATP (GO:0033198)2.96051204
81substrate-independent telencephalic tangential migration (GO:0021826)2.95709424
82substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95709424
83regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.94962395
84positive regulation of heat generation (GO:0031652)2.94839186
85branching involved in labyrinthine layer morphogenesis (GO:0060670)2.94614968
86regulation of T-helper 1 cell differentiation (GO:0045625)2.94579662
87glycosphingolipid biosynthetic process (GO:0006688)2.93398788
88replicative senescence (GO:0090399)2.92643650
89immunoglobulin mediated immune response (GO:0016064)2.91057979
90renal tubule morphogenesis (GO:0061333)2.88604088
91neutrophil activation (GO:0042119)2.87095635
92regulation of synaptic transmission, glutamatergic (GO:0051966)2.86383477
93macrophage activation involved in immune response (GO:0002281)2.86298170
94preassembly of GPI anchor in ER membrane (GO:0016254)2.85881783
95facial nerve structural organization (GO:0021612)2.85236390
96regulation of memory T cell differentiation (GO:0043380)2.84787031
97purinergic receptor signaling pathway (GO:0035587)2.81858145
98* indolalkylamine metabolic process (GO:0006586)2.81843441
99myeloid cell activation involved in immune response (GO:0002275)2.79689479
100regulation of gamma-delta T cell activation (GO:0046643)2.79404785
101modulation by symbiont of host cellular process (GO:0044068)2.78477229
102DNA deamination (GO:0045006)2.76715648
103sialylation (GO:0097503)2.74364433
104cytokine production involved in immune response (GO:0002367)2.73819561
105T-helper 1 type immune response (GO:0042088)2.72666131
106positive regulation of mast cell activation (GO:0033005)2.72283194
107regulation of mast cell activation (GO:0033003)2.71166649
108L-fucose catabolic process (GO:0042355)2.70700243
109fucose catabolic process (GO:0019317)2.70700243
110L-fucose metabolic process (GO:0042354)2.70700243
111adenosine receptor signaling pathway (GO:0001973)2.70690402
112natural killer cell activation involved in immune response (GO:0002323)2.70050246
113positive regulation of response to biotic stimulus (GO:0002833)2.68884374
114tryptophan metabolic process (GO:0006568)2.67894339
115regulation of interferon-beta biosynthetic process (GO:0045357)2.67520690
116regulation of defense response to virus by host (GO:0050691)2.66687485
117positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.66641570
118regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.66641570
119positive regulation of antigen processing and presentation (GO:0002579)2.65482217
120defense response to protozoan (GO:0042832)2.64803835
121regulation of homotypic cell-cell adhesion (GO:0034110)2.63255893
122positive regulation of mRNA catabolic process (GO:0061014)2.63199392
123neutrophil activation involved in immune response (GO:0002283)2.63041193
124positive regulation of interleukin-1 beta production (GO:0032731)2.62959577
125lens fiber cell differentiation (GO:0070306)2.61891661
126granulocyte activation (GO:0036230)2.61161564
127regulation of alpha-beta T cell proliferation (GO:0046640)2.61069040
128regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.59571378
129negative regulation of myeloid cell apoptotic process (GO:0033033)2.59170036
130positive regulation of interferon-alpha production (GO:0032727)2.58375193
131positive regulation of interleukin-10 production (GO:0032733)2.58045179
132G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.57799344
133respiratory chain complex IV assembly (GO:0008535)2.57431367
134rRNA methylation (GO:0031167)2.57182723
135germinal center formation (GO:0002467)2.56630560
136phagosome maturation (GO:0090382)2.55885131
137regulation of interleukin-1 secretion (GO:0050704)2.55786278
138negative regulation of interleukin-17 production (GO:0032700)2.55116993
139regulation of cytokine production involved in inflammatory response (GO:1900015)2.53879111
140regulation of hypersensitivity (GO:0002883)2.52721450
141mitochondrion distribution (GO:0048311)2.51679426
142C-terminal protein lipidation (GO:0006501)2.51495843
143kynurenine metabolic process (GO:0070189)2.49938887
144behavioral response to ethanol (GO:0048149)2.49669839
145adaptation of signaling pathway (GO:0023058)2.46438653
146detection of biotic stimulus (GO:0009595)2.45942109
147ionotropic glutamate receptor signaling pathway (GO:0035235)2.45481635
148metallo-sulfur cluster assembly (GO:0031163)2.45248672
149iron-sulfur cluster assembly (GO:0016226)2.45248672
150regulation of T-helper cell differentiation (GO:0045622)2.45018289
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44708408
152motile cilium assembly (GO:0044458)2.44072652
153positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.43897912
154hepatocyte differentiation (GO:0070365)2.43615007
155mast cell activation (GO:0045576)2.43122057
156positive regulation of mast cell degranulation (GO:0043306)2.42377452
157positive regulation of mast cell activation involved in immune response (GO:0033008)2.42377452
158positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.42080446
159regulation of T-helper 1 type immune response (GO:0002825)2.41346002
160positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.40568048
161modulation by virus of host process (GO:0019054)2.40339848
162positive regulation of T-helper 1 type immune response (GO:0002827)2.40285384
163positive regulation of T-helper cell differentiation (GO:0045624)2.40223911
164positive regulation of toll-like receptor signaling pathway (GO:0034123)2.40213103
165negative regulation of interleukin-12 production (GO:0032695)2.39891850
166interferon-gamma-mediated signaling pathway (GO:0060333)2.39424256
167positive regulation of developmental pigmentation (GO:0048087)2.38190959
168cytokine biosynthetic process (GO:0042089)2.38158299
169regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.37112704
170positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.37112704
171RNA destabilization (GO:0050779)2.36297723
172macrophage activation (GO:0042116)2.36256609
173developmental pigmentation (GO:0048066)2.34164292
174rRNA modification (GO:0000154)2.34032847
175neuron cell-cell adhesion (GO:0007158)2.33671936
176histone H3-K4 trimethylation (GO:0080182)2.33430021
177cilium or flagellum-dependent cell motility (GO:0001539)2.33105536
178modulation of growth of symbiont involved in interaction with host (GO:0044144)2.32958316
179regulation of growth of symbiont in host (GO:0044126)2.32958316
180negative regulation of growth of symbiont in host (GO:0044130)2.32958316
181negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.32958316
182regulation of heat generation (GO:0031650)2.32165649
183regulation of glutamate receptor signaling pathway (GO:1900449)2.31887633
184positive regulation of interleukin-12 production (GO:0032735)2.31075506
185oligosaccharide catabolic process (GO:0009313)2.30612579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.50622681
2AR_21572438_ChIP-Seq_LNCaP_Human3.29607782
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.05458023
4ZNF274_21170338_ChIP-Seq_K562_Hela2.98353425
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.79983600
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.61116279
7EZH2_22144423_ChIP-Seq_EOC_Human2.56072748
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.43940956
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.29489167
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.20776638
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10326263
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09588496
13SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.09309059
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04255576
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02012612
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.01748553
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.97410663
18VDR_22108803_ChIP-Seq_LS180_Human1.93828831
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92288236
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88606312
21GATA1_22025678_ChIP-Seq_K562_Human1.85844611
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80838185
23ER_23166858_ChIP-Seq_MCF-7_Human1.70884033
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.70678640
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.70391188
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.64514585
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.63197156
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62644768
29RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.61408469
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.59793291
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.59374995
32MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55388270
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.55245714
34VDR_24787735_ChIP-Seq_THP-1_Human1.54605967
35GATA3_26560356_Chip-Seq_TH2_Human1.53365970
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.51882206
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.51882206
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51658496
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50869670
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50606060
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.49632574
42P300_19829295_ChIP-Seq_ESCs_Human1.47867597
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.47674980
44SCL_19346495_ChIP-Seq_HPC-7_Human1.46961742
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46907795
46TAF15_26573619_Chip-Seq_HEK293_Human1.43726200
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43651775
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43549432
49TP53_22573176_ChIP-Seq_HFKS_Human1.41962472
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41344916
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39868702
52* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39680155
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.39145672
54AHR_22903824_ChIP-Seq_MCF-7_Human1.38413523
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38275623
56NANOG_20526341_ChIP-Seq_ESCs_Human1.38206251
57IRF8_27001747_Chip-Seq_BMDM_Mouse1.36464466
58SMAD4_21799915_ChIP-Seq_A2780_Human1.36168247
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35910849
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34996396
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34725441
62CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.34471984
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.33909672
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.33874778
65CTBP2_25329375_ChIP-Seq_LNCAP_Human1.33796767
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.33189531
67TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32574904
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32574904
69SMAD3_21741376_ChIP-Seq_EPCs_Human1.31967133
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.31877018
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.31402726
72LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30574683
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.30240504
74* BCL6_27268052_Chip-Seq_Bcells_Human1.29762369
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.29451482
76KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.29306713
77REST_21632747_ChIP-Seq_MESCs_Mouse1.28882532
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28609065
79* P53_21459846_ChIP-Seq_SAOS-2_Human1.27901460
80DROSHA_22980978_ChIP-Seq_HELA_Human1.27720069
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.27065949
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.26568651
83TAL1_26923725_Chip-Seq_HPCs_Mouse1.26071031
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25158409
85PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.25097863
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24926087
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24215933
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24003103
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23616384
90STAT3_23295773_ChIP-Seq_U87_Human1.23594985
91NANOG_18555785_Chip-Seq_ESCs_Mouse1.22851292
92RNF2_27304074_Chip-Seq_NSC_Mouse1.22234429
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21769337
94AR_25329375_ChIP-Seq_VCAP_Human1.21473989
95ERA_21632823_ChIP-Seq_H3396_Human1.21393501
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20763476
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.20627546
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20351562
99TAF2_19829295_ChIP-Seq_ESCs_Human1.18791327
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18559746
101SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18330241
102GATA2_21666600_ChIP-Seq_HMVEC_Human1.18304450
103RUNX_20019798_ChIP-Seq_JUKART_Human1.17876148
104CMYC_18555785_Chip-Seq_ESCs_Mouse1.17338080
105SPI1_23547873_ChIP-Seq_NB4_Human1.16447160
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.15473774
107RUNX2_22187159_ChIP-Seq_PCA_Human1.14709002
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14010309
109RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13932927
110GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13900137
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13843322
112TCF4_23295773_ChIP-Seq_U87_Human1.13112708
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12719534
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12326365
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11644023
116STAT3_18555785_Chip-Seq_ESCs_Mouse1.11563726
117SOX2_19829295_ChIP-Seq_ESCs_Human1.11546569
118NANOG_19829295_ChIP-Seq_ESCs_Human1.11546569
119HOXB7_26014856_ChIP-Seq_BT474_Human1.11001816
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10863820
121SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10859596
122NFE2_27457419_Chip-Seq_LIVER_Mouse1.10739163
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10170007
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10049261
125SMRT_27268052_Chip-Seq_Bcells_Human1.09360075
126EWS_26573619_Chip-Seq_HEK293_Human1.09227254
127P300_27268052_Chip-Seq_Bcells_Human1.08387694
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.08215727
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08078300
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.07891096
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07741634
132GABP_17652178_ChIP-ChIP_JURKAT_Human1.06872115
133P53_22387025_ChIP-Seq_ESCs_Mouse1.06692056
134SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06645176
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05770506
136AR_20517297_ChIP-Seq_VCAP_Human1.05463984
137PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05175901
138BCAT_22108803_ChIP-Seq_LS180_Human1.04894422
139* NCOR_22424771_ChIP-Seq_293T_Human1.04839017
140FLI1_27457419_Chip-Seq_LIVER_Mouse1.04532950
141PCGF2_27294783_Chip-Seq_ESCs_Mouse1.04322358
142CBP_20019798_ChIP-Seq_JUKART_Human1.03723625
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03723625
144IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02431148
145GATA3_27048872_Chip-Seq_THYMUS_Human1.02430730
146FUS_26573619_Chip-Seq_HEK293_Human1.01508752
147FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01383056
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01230297
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00777216
150CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00268368
151FOXA1_25329375_ChIP-Seq_VCAP_Human0.98841522
152FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98841522
153MYC_19829295_ChIP-Seq_ESCs_Human0.98768999
154EST1_17652178_ChIP-ChIP_JURKAT_Human0.97836919
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97497614
156CBX2_27304074_Chip-Seq_ESCs_Mouse0.97357007
157ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97289487
158FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96725370
159STAT4_19710469_ChIP-ChIP_TH1__Mouse0.96285481
160FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96118996
161SOX2_18555785_Chip-Seq_ESCs_Mouse0.95361370
162PU1_27457419_Chip-Seq_LIVER_Mouse0.95075903
163EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.94651978
164MYC_18940864_ChIP-ChIP_HL60_Human0.94427411
165FLI1_21867929_ChIP-Seq_TH2_Mouse0.94075932
166CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92996234
167TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92899593
168CDX2_22108803_ChIP-Seq_LS180_Human0.92379046
169VDR_23849224_ChIP-Seq_CD4+_Human0.91800426
170IRF1_19129219_ChIP-ChIP_H3396_Human0.91159625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.21156364
2MP0000569_abnormal_digit_pigmentation4.01038051
3MP0008260_abnormal_autophagy3.95184511
4MP0003172_abnormal_lysosome_physiology3.02620956
5MP0004859_abnormal_synaptic_plasticity2.90721910
6MP0001986_abnormal_taste_sensitivity2.83750749
7MP0005171_absent_coat_pigmentation2.83132870
8MP0009764_decreased_sensitivity_to2.58080339
9MP0004782_abnormal_surfactant_physiolog2.44088896
10MP0009785_altered_susceptibility_to2.36005544
11MP0003195_calcinosis2.33139659
12MP0001835_abnormal_antigen_presentation2.20876085
13MP0006082_CNS_inflammation2.12454420
14MP0005387_immune_system_phenotype2.11704183
15MP0001790_abnormal_immune_system2.11704183
16MP0005551_abnormal_eye_electrophysiolog2.09464698
17MP0000015_abnormal_ear_pigmentation2.05363643
18MP0001188_hyperpigmentation2.03211038
19MP0003436_decreased_susceptibility_to2.01629804
20MP0002148_abnormal_hypersensitivity_rea1.98550924
21MP0005646_abnormal_pituitary_gland1.97109356
22MP0002933_joint_inflammation1.91289625
23MP0002254_reproductive_system_inflammat1.84895340
24MP0009745_abnormal_behavioral_response1.82627963
25MP0002419_abnormal_innate_immunity1.82110796
26MP0002736_abnormal_nociception_after1.79920300
27MP0005310_abnormal_salivary_gland1.77734519
28MP0005174_abnormal_tail_pigmentation1.75284304
29MP0002638_abnormal_pupillary_reflex1.72183054
30MP0009278_abnormal_bone_marrow1.68366171
31MP0003878_abnormal_ear_physiology1.67984015
32MP0005377_hearing/vestibular/ear_phenot1.67984015
33MP0005671_abnormal_response_to1.63708850
34MP0000371_diluted_coat_color1.62816478
35MP0003635_abnormal_synaptic_transmissio1.61707641
36MP0002063_abnormal_learning/memory/cond1.61368024
37MP0005503_abnormal_tendon_morphology1.60262336
38MP0009046_muscle_twitch1.59607246
39MP0005000_abnormal_immune_tolerance1.58339427
40MP0009697_abnormal_copulation1.54799262
41MP0004742_abnormal_vestibular_system1.51276701
42MP0002064_seizures1.49702695
43MP0006276_abnormal_autonomic_nervous1.47715145
44MP0006292_abnormal_olfactory_placode1.46569230
45MP0001502_abnormal_circadian_rhythm1.44924542
46MP0009765_abnormal_xenobiotic_induced1.43563946
47MP0005025_abnormal_response_to1.43329997
48MP0002572_abnormal_emotion/affect_behav1.41705714
49MP0002735_abnormal_chemical_nociception1.41404916
50MP0000685_abnormal_immune_system1.39129146
51MP0005464_abnormal_platelet_physiology1.38206199
52MP0002723_abnormal_immune_serum1.38001794
53MP0001984_abnormal_olfaction1.37988814
54MP0004142_abnormal_muscle_tone1.34671774
55MP0005167_abnormal_blood-brain_barrier1.34520699
56MP0005423_abnormal_somatic_nervous1.32961861
57MP0003045_fibrosis1.32585292
58MP0001486_abnormal_startle_reflex1.32065129
59MP0004510_myositis1.32001446
60MP0001800_abnormal_humoral_immune1.31304725
61MP0001501_abnormal_sleep_pattern1.30206608
62MP0005058_abnormal_lysosome_morphology1.28176876
63MP0002452_abnormal_antigen_presenting1.27452112
64MP0003880_abnormal_central_pattern1.27335285
65MP0002272_abnormal_nervous_system1.25649039
66MP0003303_peritoneal_inflammation1.23042562
67MP0003136_yellow_coat_color1.23041224
68MP0002163_abnormal_gland_morphology1.21006061
69MP0008872_abnormal_physiological_respon1.17820467
70MP0005394_taste/olfaction_phenotype1.17554137
71MP0005499_abnormal_olfactory_system1.17554137
72MP0001819_abnormal_immune_cell1.16769776
73MP0008469_abnormal_protein_level1.16575501
74MP0002876_abnormal_thyroid_physiology1.16386419
75MP0004381_abnormal_hair_follicle1.15646108
76MP0002420_abnormal_adaptive_immunity1.14654237
77MP0003879_abnormal_hair_cell1.14273829
78MP0000538_abnormal_urinary_bladder1.13830954
79MP0004147_increased_porphyrin_level1.13498116
80MP0004858_abnormal_nervous_system1.10977561
81MP0006072_abnormal_retinal_apoptosis1.10124970
82MP0002405_respiratory_system_inflammati1.09566754
83MP0002067_abnormal_sensory_capabilities1.07583124
84MP0002075_abnormal_coat/hair_pigmentati1.07107367
85MP0005253_abnormal_eye_physiology1.06755486
86MP0003279_aneurysm1.04837138
87MP0002928_abnormal_bile_duct1.04294386
88MP0002734_abnormal_mechanical_nocicepti1.04028940
89MP0008789_abnormal_olfactory_epithelium1.02702558
90MP0008875_abnormal_xenobiotic_pharmacok1.02472263
91MP0001177_atelectasis1.02250073
92MP0002653_abnormal_ependyma_morphology1.00439036
93MP0001533_abnormal_skeleton_physiology0.99774375
94MP0002938_white_spotting0.99767668
95MP0001968_abnormal_touch/_nociception0.99693969
96MP0000689_abnormal_spleen_morphology0.96847307
97MP0000716_abnormal_immune_system0.96572270
98MP0001485_abnormal_pinna_reflex0.96044122
99MP0004947_skin_inflammation0.95951045
100MP0001919_abnormal_reproductive_system0.94640533
101MP0003646_muscle_fatigue0.94239535
102MP0005390_skeleton_phenotype0.93924242
103MP0000566_synostosis0.93121751
104MP0002998_abnormal_bone_remodeling0.92504935
105MP0005386_behavior/neurological_phenoty0.92278412
106MP0004924_abnormal_behavior0.92278412
107MP0003011_delayed_dark_adaptation0.91792790
108MP0003724_increased_susceptibility_to0.91726456
109MP0003252_abnormal_bile_duct0.90825323
110MP0004885_abnormal_endolymph0.89615958
111MP0000343_altered_response_to0.89554278
112MP0001764_abnormal_homeostasis0.89545840
113MP0003806_abnormal_nucleotide_metabolis0.89466261
114MP0002102_abnormal_ear_morphology0.88905678
115MP0006054_spinal_hemorrhage0.88072090
116MP0004133_heterotaxia0.87787974
117MP0005410_abnormal_fertilization0.87563671
118MP0001324_abnormal_eye_pigmentation0.87205322
119MP0003787_abnormal_imprinting0.86740291
120MP0000858_altered_metastatic_potential0.85980271
121MP0005365_abnormal_bile_salt0.85533823
122MP0001845_abnormal_inflammatory_respons0.85275550
123MP0002249_abnormal_larynx_morphology0.84680091
124MP0008004_abnormal_stomach_pH0.81325713
125MP0001186_pigmentation_phenotype0.81175306
126MP0001970_abnormal_pain_threshold0.80051963
127MP0010307_abnormal_tumor_latency0.80029025
128MP0002332_abnormal_exercise_endurance0.79705639
129MP0005084_abnormal_gallbladder_morpholo0.79391732
130MP0002138_abnormal_hepatobiliary_system0.79298465
131MP0000372_irregular_coat_pigmentation0.78976034
132MP0000778_abnormal_nervous_system0.78599655
133MP0002822_catalepsy0.78516723
134MP0004043_abnormal_pH_regulation0.78010881
135MP0002398_abnormal_bone_marrow0.77921924
136MP0008961_abnormal_basal_metabolism0.77365374
137MP0000230_abnormal_systemic_arterial0.77054008
138MP0005379_endocrine/exocrine_gland_phen0.76703667
139MP0002693_abnormal_pancreas_physiology0.76448539
140MP0005367_renal/urinary_system_phenotyp0.76054520
141MP0000516_abnormal_urinary_system0.76054520
142MP0001545_abnormal_hematopoietic_system0.75929784
143MP0005397_hematopoietic_system_phenotyp0.75929784
144MP0008874_decreased_physiological_sensi0.73623055
145MP0010155_abnormal_intestine_physiology0.73573098
146MP0005508_abnormal_skeleton_morphology0.73521830
147MP0005195_abnormal_posterior_eye0.72070390

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)4.65061107
2Optic neuritis (HP:0100653)4.65061107
3Orchitis (HP:0100796)3.92809419
4Absent/shortened dynein arms (HP:0200106)3.85338522
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.85338522
6Scanning speech (HP:0002168)3.79637607
7Thick nail (HP:0001805)3.65163246
8Recurrent abscess formation (HP:0002722)3.60202233
9Protruding tongue (HP:0010808)3.53674442
10Congenital stationary night blindness (HP:0007642)3.52348369
11Stomatitis (HP:0010280)3.52308350
12Choroideremia (HP:0001139)3.49773854
13Abnormality of macrophages (HP:0004311)3.46072773
14Postural instability (HP:0002172)3.28201238
15Recurrent bacterial skin infections (HP:0005406)3.21392805
16Mediastinal lymphadenopathy (HP:0100721)3.15730320
17Supranuclear gaze palsy (HP:0000605)3.15697323
18Neoplasm of the adrenal cortex (HP:0100641)3.12628947
19Long nose (HP:0003189)3.10143191
20Eczematoid dermatitis (HP:0000976)3.09137266
21Chronic hepatic failure (HP:0100626)3.05615745
22Myositis (HP:0100614)3.03821940
23Parakeratosis (HP:0001036)3.02201569
24Slow saccadic eye movements (HP:0000514)3.00282806
25Cerebral aneurysm (HP:0004944)2.97605697
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87930405
27Severe visual impairment (HP:0001141)2.87606874
28Stomach cancer (HP:0012126)2.87406399
29Chronic mucocutaneous candidiasis (HP:0002728)2.82789839
30Attenuation of retinal blood vessels (HP:0007843)2.74766613
31Abnormal hair whorl (HP:0010721)2.72267270
32Febrile seizures (HP:0002373)2.63055079
33Polydipsia (HP:0001959)2.62790293
34Abnormal drinking behavior (HP:0030082)2.62790293
35Tented upper lip vermilion (HP:0010804)2.61962059
36Albinism (HP:0001022)2.61913002
37Mild short stature (HP:0003502)2.60146270
38Cystic liver disease (HP:0006706)2.57369653
39Long foot (HP:0001833)2.53679859
40Recurrent gram-negative bacterial infections (HP:0005420)2.52393026
41Tubular atrophy (HP:0000092)2.52360344
42Pancreatic cysts (HP:0001737)2.51933378
43Abnormal respiratory motile cilium morphology (HP:0005938)2.50713939
44Abnormal respiratory epithelium morphology (HP:0012253)2.50713939
45Pulmonary infiltrates (HP:0002113)2.46321556
46Submucous cleft hard palate (HP:0000176)2.46288610
47Abnormal ciliary motility (HP:0012262)2.46091438
48Vasculitis (HP:0002633)2.45837562
49Nephronophthisis (HP:0000090)2.45218563
50Keratoconjunctivitis sicca (HP:0001097)2.42621364
51Fetal akinesia sequence (HP:0001989)2.37838113
52Abolished electroretinogram (ERG) (HP:0000550)2.36737723
53Abnormal albumin level (HP:0012116)2.35704558
54Hypoalbuminemia (HP:0003073)2.35704558
55Medial flaring of the eyebrow (HP:0010747)2.32162165
56Pulmonary artery stenosis (HP:0004415)2.31281801
57True hermaphroditism (HP:0010459)2.30955247
58Plagiocephaly (HP:0001357)2.29898757
59Generalized hypopigmentation (HP:0007513)2.24995693
60Cheilitis (HP:0100825)2.23539958
61Xerostomia (HP:0000217)2.21776265
62Sensory axonal neuropathy (HP:0003390)2.20909566
63Retinal dysplasia (HP:0007973)2.18801985
64Increased IgM level (HP:0003496)2.18509442
65Fair hair (HP:0002286)2.17577375
66Hip dysplasia (HP:0001385)2.17325828
67Facial hemangioma (HP:0000329)2.17317511
68Acute necrotizing encephalopathy (HP:0006965)2.17307990
69Broad-based gait (HP:0002136)2.17185672
70Bony spicule pigmentary retinopathy (HP:0007737)2.15545884
71Methylmalonic aciduria (HP:0012120)2.12873926
72Gingivitis (HP:0000230)2.12447846
73Hyperventilation (HP:0002883)2.11321754
74Epileptic encephalopathy (HP:0200134)2.11239971
75Abnormality of salivation (HP:0100755)2.10592453
76Abnormality of the vertebral endplates (HP:0005106)2.10197529
77Keratoconjunctivitis (HP:0001096)2.09721003
78Cortical dysplasia (HP:0002539)2.09280093
79Mesangial abnormality (HP:0001966)2.08116825
80Optic disc pallor (HP:0000543)2.07281076
81Hemoptysis (HP:0002105)2.05914254
82Polyuria (HP:0000103)2.05394693
83Acute hepatic failure (HP:0006554)2.05374260
84Hepatocellular necrosis (HP:0001404)2.05046526
85Drooling (HP:0002307)2.05000547
86Excessive salivation (HP:0003781)2.05000547
87Chronic bronchitis (HP:0004469)2.04896650
88Generalized hypopigmentation of hair (HP:0011358)2.03339289
89Septo-optic dysplasia (HP:0100842)2.02911443
90Pendular nystagmus (HP:0012043)2.02889294
91Rib fusion (HP:0000902)2.02594242
92Vacuolated lymphocytes (HP:0001922)2.01810771
93Impaired social interactions (HP:0000735)2.00982123
94Abnormal social behavior (HP:0012433)2.00982123
95Decreased electroretinogram (ERG) amplitude (HP:0000654)1.99892642
96Absent frontal sinuses (HP:0002688)1.99109126
97Congenital sensorineural hearing impairment (HP:0008527)1.98987599
98White forelock (HP:0002211)1.98694503
99Blue irides (HP:0000635)1.97899184
100Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.97299477
101Type II lissencephaly (HP:0007260)1.97185893
102Abnormality of the renal medulla (HP:0100957)1.96584468
103Decreased central vision (HP:0007663)1.96414711
104Increased CSF lactate (HP:0002490)1.96107285
105Molar tooth sign on MRI (HP:0002419)1.95706053
106Abnormality of midbrain morphology (HP:0002418)1.95706053
107Elevated erythrocyte sedimentation rate (HP:0003565)1.95627448
108Poor eye contact (HP:0000817)1.94237693
109Abnormal respiratory motile cilium physiology (HP:0012261)1.94175170
110Recurrent skin infections (HP:0001581)1.93406798
111Abnormal mitochondria in muscle tissue (HP:0008316)1.91818770
112Hypokinesia (HP:0002375)1.91106958
113Mitochondrial inheritance (HP:0001427)1.91104138
114Hematochezia (HP:0002573)1.89973112
115Obstructive lung disease (HP:0006536)1.88868510
116Chronic obstructive pulmonary disease (HP:0006510)1.88868510
117Alveolar cell carcinoma (HP:0006519)1.88558721
118Hypoplastic ischia (HP:0003175)1.88375581
119Mutism (HP:0002300)1.87344916
120Leukocytosis (HP:0001974)1.86680153
121Gastrointestinal infarctions (HP:0005244)1.86267185
122Testicular atrophy (HP:0000029)1.84313830
123Genetic anticipation (HP:0003743)1.84194009
124Increased cerebral lipofuscin (HP:0011813)1.83944873
125Bile duct proliferation (HP:0001408)1.83933304
126Abnormal biliary tract physiology (HP:0012439)1.83933304
127Progressive macrocephaly (HP:0004481)1.83187291
128Increased neuronal autofluorescent lipopigment (HP:0002074)1.82990565
129Poikiloderma (HP:0001029)1.82568336
130Scrotal hypoplasia (HP:0000046)1.82189940
131Abnormality of dental color (HP:0011073)1.81534112
132Abnormality of the renal cortex (HP:0011035)1.81467732
133Peritonitis (HP:0002586)1.81392880
134Elfin facies (HP:0004428)1.80943320
135Prominent supraorbital ridges (HP:0000336)1.80535705
136Tachypnea (HP:0002789)1.80173420
137Abnormality of saccadic eye movements (HP:0000570)1.79130303
138Facial diplegia (HP:0001349)1.78668352
139Joint swelling (HP:0001386)1.78201035
140Renal Fanconi syndrome (HP:0001994)1.77921542
141Amyloidosis (HP:0011034)1.77318215
142Decreased circulating renin level (HP:0003351)1.76363954
143Acute encephalopathy (HP:0006846)1.76118493
144Retinitis pigmentosa (HP:0000510)1.75748406
145Abnormal rod and cone electroretinograms (HP:0008323)1.75629688
146Pancreatic fibrosis (HP:0100732)1.75291675
147Nasal polyposis (HP:0100582)1.75243290
148Congenital primary aphakia (HP:0007707)1.75070452
149Keratitis (HP:0000491)1.74964148
150Enlarged epiphyses (HP:0010580)1.74873164
151Gangrene (HP:0100758)1.74501039
152Rectovaginal fistula (HP:0000143)1.73443715
153Rectal fistula (HP:0100590)1.73443715
154Absent speech (HP:0001344)1.73282865
155Hepatic necrosis (HP:0002605)1.73270494
156Patchy hypopigmentation of hair (HP:0011365)1.73059899
157Progressive cerebellar ataxia (HP:0002073)1.72228421
158Chromosomal breakage induced by crosslinking agents (HP:0003221)1.71956408
159Abnormality of the endocardium (HP:0004306)1.71266317
160Neonatal short-limb short stature (HP:0008921)1.70868158
161Abnormality of macular pigmentation (HP:0008002)1.70662414
162Tinnitus (HP:0000360)1.70126502
163Gait imbalance (HP:0002141)1.70022055
164Poor speech (HP:0002465)1.69836327
165Stenosis of the external auditory canal (HP:0000402)1.69479620
166Recurrent fungal infections (HP:0002841)1.68771678
167Dyschromatopsia (HP:0007641)1.68566473
168Cerebellar dysplasia (HP:0007033)1.67364753
169Decreased motor nerve conduction velocity (HP:0003431)1.66992136
170Irregular vertebral endplates (HP:0003301)1.66320552
171Hypothermia (HP:0002045)1.65829381
172Abnormality of the fingertips (HP:0001211)1.65016679
173Flat capital femoral epiphysis (HP:0003370)1.63376461
174Impaired smooth pursuit (HP:0007772)1.62934877
175Epiphyseal dysplasia (HP:0002656)1.60511399
176Aplasia/Hypoplasia of the fovea (HP:0008060)1.59550004
177Hypoplasia of the fovea (HP:0007750)1.59550004
178Recurrent cutaneous fungal infections (HP:0011370)1.59104601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK5.15288948
2INSRR4.69192564
3CASK3.38276306
4MAP4K23.20626166
5MAP3K143.03032756
6IRAK42.99707677
7ACVR1B2.89147012
8FRK2.86803041
9RIPK42.41614011
10PRKCH2.38674388
11NTRK32.36661233
12NUAK12.32667401
13TLK12.23440489
14TXK2.18114994
15IRAK32.15396493
16BLK2.05336768
17NEK61.99098362
18IRAK21.96426538
19MAP2K71.95420300
20TBK11.87439789
21IKBKE1.86482689
22TIE11.84309871
23MST41.80877528
24BMPR1B1.79392142
25STK161.68560517
26PINK11.67418163
27PRPF4B1.65087492
28GRK11.62231918
29TRPM71.59379217
30SIK31.58671216
31MAP4K11.58059391
32ADRBK21.56797226
33MATK1.54937990
34EIF2AK31.52485110
35MAPK151.47036091
36NTRK21.42477537
37CDK31.39597060
38WNK31.39246512
39TEC1.37867095
40TRIM281.35212587
41LATS11.33910986
42ERBB31.33617726
43SGK21.32171980
44BCKDK1.29125878
45CSF1R1.26558815
46ADRBK11.25454568
47GRK71.25293371
48BMPR21.24023219
49CHUK1.21816344
50BTK1.17051091
51PLK21.04706224
52STK241.03420933
53DAPK21.02649541
54WNK11.02510296
55MAP3K121.01850987
56MAP3K41.00604057
57SGK4941.00185071
58SGK2231.00185071
59CAMKK21.00048505
60TAOK30.99779000
61IKBKB0.98333206
62PKN10.92738415
63CSK0.90019311
64SGK30.89775353
65PDGFRA0.89712937
66AKT30.89398591
67JAK10.87613065
68PDK20.84456058
69JAK30.81264804
70CSNK1G30.79330965
71YES10.78834654
72SGK10.77852150
73FGFR40.77589987
74ARAF0.77174319
75PIK3CA0.76964531
76TNK20.76571502
77MAPK70.74132579
78KIT0.74009338
79MARK10.73912400
80MAP3K130.72844984
81PIM20.70670221
82MAPK130.67799057
83BRSK20.67456438
84ERBB40.67101006
85TNIK0.66509429
86PRKCE0.65561244
87LYN0.63659748
88WNK40.63520422
89BCR0.63267423
90CSNK1A1L0.62955542
91CSNK1G10.62256593
92SYK0.62114661
93GRK60.61371559
94IRAK10.60840810
95PRKCQ0.60677055
96PLK30.59560920
97CAMK2B0.59499273
98FES0.59459549
99HCK0.59005899
100OXSR10.57912337
101NME20.57194733
102FGFR20.56287694
103TYK20.54934119
104JAK20.54292399
105PBK0.54236216
106PRKG10.54017054
107CSNK1G20.53536002
108MUSK0.52435728
109PRKCD0.50729328
110SIK20.49225966
111PAK30.48529168
112MAP3K50.47641428
113MARK30.47195813
114STK30.46885252
115ABL10.46789353
116TGFBR10.46110571
117PDGFRB0.45400047
118LCK0.44898452
119ERN10.44757140
120IGF1R0.44265833
121TTK0.44097081
122VRK10.43729913
123MINK10.43433109
124PRKCG0.43359561
125PIM10.42639139
126ITK0.41607469
127TYRO30.37131485
128PDK10.37045469
129RPS6KA20.36747887
130EIF2AK20.36309276
131VRK20.35897377
132FGFR30.35505556
133CLK10.34891061
134SRC0.34334619
135* PRKCA0.34010368
136WEE10.33892535
137MOS0.33866417
138GRK50.33672772
139CAMK2D0.33278656
140INSR0.31490851
141FGR0.30731289
142PAK60.30057103
143FGFR10.29878452
144ATR0.29712982
145MAP2K60.28460621
146MAPK100.27730360
147MAPKAPK50.27663260
148CDK50.27372116
149DYRK20.26508970
150CAMK2G0.25752173
151CAMK2A0.25478751
152PRKG20.25393478
153RPS6KB10.25314643

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.74603539
2Allograft rejection_Homo sapiens_hsa053302.72657131
3NOD-like receptor signaling pathway_Homo sapiens_hsa046212.38984785
4Graft-versus-host disease_Homo sapiens_hsa053322.26456713
5Type I diabetes mellitus_Homo sapiens_hsa049402.20504977
6Protein export_Homo sapiens_hsa030602.15618475
7Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.92282646
8Leishmaniasis_Homo sapiens_hsa051401.92268200
9Rheumatoid arthritis_Homo sapiens_hsa053231.89611265
10Oxidative phosphorylation_Homo sapiens_hsa001901.84907389
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.82720464
12Nicotine addiction_Homo sapiens_hsa050331.80916217
13RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.78475455
14Collecting duct acid secretion_Homo sapiens_hsa049661.76992965
15Phototransduction_Homo sapiens_hsa047441.76240491
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76208948
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.74569934
18Vitamin B6 metabolism_Homo sapiens_hsa007501.74516412
19Sulfur relay system_Homo sapiens_hsa041221.67004928
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.58487577
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58049708
22Synaptic vesicle cycle_Homo sapiens_hsa047211.55730611
23Autoimmune thyroid disease_Homo sapiens_hsa053201.52907572
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.51680011
25Pertussis_Homo sapiens_hsa051331.51414626
26Morphine addiction_Homo sapiens_hsa050321.49988289
27Tuberculosis_Homo sapiens_hsa051521.47019123
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.44413822
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42066049
30TNF signaling pathway_Homo sapiens_hsa046681.39661455
31Malaria_Homo sapiens_hsa051441.39498632
32SNARE interactions in vesicular transport_Homo sapiens_hsa041301.35640993
33Measles_Homo sapiens_hsa051621.35166698
34Parkinsons disease_Homo sapiens_hsa050121.34798086
35Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.31618026
36Influenza A_Homo sapiens_hsa051641.31125579
37African trypanosomiasis_Homo sapiens_hsa051431.28700805
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.26493847
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24837832
40Type II diabetes mellitus_Homo sapiens_hsa049301.24767932
41Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24101930
42Linoleic acid metabolism_Homo sapiens_hsa005911.22903672
43Phagosome_Homo sapiens_hsa041451.21603160
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19068168
45Olfactory transduction_Homo sapiens_hsa047401.18407960
46Arachidonic acid metabolism_Homo sapiens_hsa005901.10818859
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10686414
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09673862
49Fanconi anemia pathway_Homo sapiens_hsa034601.09521472
50Circadian entrainment_Homo sapiens_hsa047131.09519188
51Ether lipid metabolism_Homo sapiens_hsa005651.09201265
52Taste transduction_Homo sapiens_hsa047421.08495885
53Regulation of autophagy_Homo sapiens_hsa041401.08364308
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06225380
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05738722
56Peroxisome_Homo sapiens_hsa041461.05182168
57Legionellosis_Homo sapiens_hsa051341.03594123
58Inositol phosphate metabolism_Homo sapiens_hsa005621.02929669
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.01949759
60Selenocompound metabolism_Homo sapiens_hsa004501.00937802
61Shigellosis_Homo sapiens_hsa051311.00908042
62Nitrogen metabolism_Homo sapiens_hsa009101.00408757
63B cell receptor signaling pathway_Homo sapiens_hsa046620.99637039
64Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99484782
65Osteoclast differentiation_Homo sapiens_hsa043800.96252377
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95168834
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93441372
68Other glycan degradation_Homo sapiens_hsa005110.93308061
69Asthma_Homo sapiens_hsa053100.93019625
70Glutamatergic synapse_Homo sapiens_hsa047240.92338808
71T cell receptor signaling pathway_Homo sapiens_hsa046600.90867806
72* Tryptophan metabolism_Homo sapiens_hsa003800.90543408
73Chemokine signaling pathway_Homo sapiens_hsa040620.89504132
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87238339
75GABAergic synapse_Homo sapiens_hsa047270.87071391
76Hematopoietic cell lineage_Homo sapiens_hsa046400.85303217
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84948905
78Alzheimers disease_Homo sapiens_hsa050100.84696176
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84102691
80Ovarian steroidogenesis_Homo sapiens_hsa049130.83514188
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83106529
82Basal transcription factors_Homo sapiens_hsa030220.79884523
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79637164
84Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78675609
85Sphingolipid metabolism_Homo sapiens_hsa006000.74018433
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73465584
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68819949
88Apoptosis_Homo sapiens_hsa042100.68504277
89Salivary secretion_Homo sapiens_hsa049700.68415802
90Staphylococcus aureus infection_Homo sapiens_hsa051500.68385043
91Huntingtons disease_Homo sapiens_hsa050160.67854664
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.66240292
93Vibrio cholerae infection_Homo sapiens_hsa051100.65264769
94Homologous recombination_Homo sapiens_hsa034400.64418491
95Antigen processing and presentation_Homo sapiens_hsa046120.63138052
96Hepatitis C_Homo sapiens_hsa051600.62999016
97Butanoate metabolism_Homo sapiens_hsa006500.62973918
98Calcium signaling pathway_Homo sapiens_hsa040200.61679012
99Insulin secretion_Homo sapiens_hsa049110.60859692
100Herpes simplex infection_Homo sapiens_hsa051680.60196814
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59572280
102Serotonergic synapse_Homo sapiens_hsa047260.59063909
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.57929371
104Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57376438
105ErbB signaling pathway_Homo sapiens_hsa040120.57103946
106MAPK signaling pathway_Homo sapiens_hsa040100.56722615
107Ras signaling pathway_Homo sapiens_hsa040140.56282084
108Toxoplasmosis_Homo sapiens_hsa051450.55950679
109Salmonella infection_Homo sapiens_hsa051320.55096757
110Cholinergic synapse_Homo sapiens_hsa047250.54204072
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53106989
112Lysosome_Homo sapiens_hsa041420.52641402
113ABC transporters_Homo sapiens_hsa020100.52032480
114Axon guidance_Homo sapiens_hsa043600.50329901
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.48861137
116Long-term depression_Homo sapiens_hsa047300.48435349
117Dorso-ventral axis formation_Homo sapiens_hsa043200.48105538
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47733016
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46784857
120Chemical carcinogenesis_Homo sapiens_hsa052040.45724599
121FoxO signaling pathway_Homo sapiens_hsa040680.44883476
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.44060396
123Cocaine addiction_Homo sapiens_hsa050300.43850297
124Fructose and mannose metabolism_Homo sapiens_hsa000510.43363098
125Mineral absorption_Homo sapiens_hsa049780.42378627
126Glycosaminoglycan degradation_Homo sapiens_hsa005310.41351657
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39390247
128cAMP signaling pathway_Homo sapiens_hsa040240.38154547
129Proteoglycans in cancer_Homo sapiens_hsa052050.38148195
130RNA polymerase_Homo sapiens_hsa030200.37964330
131Dilated cardiomyopathy_Homo sapiens_hsa054140.37450702
132Primary immunodeficiency_Homo sapiens_hsa053400.37388330
133Melanogenesis_Homo sapiens_hsa049160.37333209
134Renin secretion_Homo sapiens_hsa049240.37173698
135Hepatitis B_Homo sapiens_hsa051610.37129627
136Steroid biosynthesis_Homo sapiens_hsa001000.36508288
137Choline metabolism in cancer_Homo sapiens_hsa052310.36008339
138Gastric acid secretion_Homo sapiens_hsa049710.35019944
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.34987047
140Platelet activation_Homo sapiens_hsa046110.31913442

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