AAR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the homolog of the yeast A1-alpha2 repressin protein that is involved in mRNA splicing. Alternately spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibroblast apoptotic process (GO:2000270)6.38447105
2cellular extravasation (GO:0045123)5.86348016
3somatic diversification of immune receptors via somatic mutation (GO:0002566)5.14382341
4somatic hypermutation of immunoglobulin genes (GO:0016446)5.14382341
5protein-cofactor linkage (GO:0018065)5.01361301
6rRNA modification (GO:0000154)4.57445268
7rRNA methylation (GO:0031167)4.53597036
8regulation of triglyceride catabolic process (GO:0010896)4.39611180
9mast cell degranulation (GO:0043303)4.33387930
10mast cell activation involved in immune response (GO:0002279)4.33387930
11proteasome assembly (GO:0043248)4.23897940
12erythrocyte maturation (GO:0043249)4.04689886
13spliceosomal complex assembly (GO:0000245)3.98524413
14histone H2A acetylation (GO:0043968)3.98483808
15negative regulation of B cell apoptotic process (GO:0002903)3.94480993
16regulation of fibroblast apoptotic process (GO:2000269)3.92812643
17protein maturation by protein folding (GO:0022417)3.85081830
18establishment of integrated proviral latency (GO:0075713)3.83580555
19peptidyl-arginine omega-N-methylation (GO:0035247)3.76304756
20telomere maintenance via semi-conservative replication (GO:0032201)3.73960813
21mannosylation (GO:0097502)3.73763973
22negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.73081289
23daunorubicin metabolic process (GO:0044597)3.71606402
24polyketide metabolic process (GO:0030638)3.71606402
25doxorubicin metabolic process (GO:0044598)3.71606402
26hepatocyte apoptotic process (GO:0097284)3.70303439
27cullin deneddylation (GO:0010388)3.69256523
28formation of translation preinitiation complex (GO:0001731)3.68110615
29COPI coating of Golgi vesicle (GO:0048205)3.63462916
30Golgi transport vesicle coating (GO:0048200)3.63462916
31CENP-A containing nucleosome assembly (GO:0034080)3.62690269
32establishment of viral latency (GO:0019043)3.57165563
33positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51094115
34protein deneddylation (GO:0000338)3.50233606
35negative regulation of ligase activity (GO:0051352)3.49761631
36negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49761631
37L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49249815
38DNA strand elongation involved in DNA replication (GO:0006271)3.47903511
39spliceosomal snRNP assembly (GO:0000387)3.42212106
40purine nucleobase biosynthetic process (GO:0009113)3.42140874
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.39991885
42signal transduction involved in DNA damage checkpoint (GO:0072422)3.39991885
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.39611241
44ribonucleoprotein complex disassembly (GO:0032988)3.38947287
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37314449
46folic acid-containing compound biosynthetic process (GO:0009396)3.34876779
47nucleobase biosynthetic process (GO:0046112)3.34460979
48chromatin remodeling at centromere (GO:0031055)3.34284959
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.34035453
50ribosomal large subunit biogenesis (GO:0042273)3.30474502
51IMP biosynthetic process (GO:0006188)3.26720013
52ribosome biogenesis (GO:0042254)3.25595392
53mitochondrial DNA metabolic process (GO:0032042)3.24347685
54tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21397236
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21397236
56ribosomal small subunit assembly (GO:0000028)3.21111357
57L-methionine salvage (GO:0071267)3.19605509
58L-methionine biosynthetic process (GO:0071265)3.19605509
59amino acid salvage (GO:0043102)3.19605509
60histone arginine methylation (GO:0034969)3.19597416
61spliceosomal tri-snRNP complex assembly (GO:0000244)3.18567373
62glycoside metabolic process (GO:0016137)3.17863808
63ribosome assembly (GO:0042255)3.17818082
64tRNA aminoacylation for protein translation (GO:0006418)3.17383727
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.16546288
66L-serine metabolic process (GO:0006563)3.14970754
67DNA strand elongation (GO:0022616)3.14934821
68rRNA processing (GO:0006364)3.13270752
69mitotic metaphase plate congression (GO:0007080)3.13054953
70tRNA aminoacylation (GO:0043039)3.13020827
71amino acid activation (GO:0043038)3.13020827
72DNA unwinding involved in DNA replication (GO:0006268)3.10736327
73telomere maintenance via recombination (GO:0000722)3.08384539
74lysosome localization (GO:0032418)3.07432134
75regulation of immunoglobulin secretion (GO:0051023)3.07193925
76NIK/NF-kappaB signaling (GO:0038061)3.05381437
77cerebellar Purkinje cell layer development (GO:0021680)3.03507843
78pteridine-containing compound biosynthetic process (GO:0042559)3.02399929
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.01577869
80NADH dehydrogenase complex assembly (GO:0010257)3.01577869
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.01577869
82tricarboxylic acid cycle (GO:0006099)2.99710991
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.98686140
84pseudouridine synthesis (GO:0001522)2.97626051
85positive regulation of ligase activity (GO:0051351)2.96994705
86rRNA metabolic process (GO:0016072)2.94845947
87tRNA methylation (GO:0030488)2.94640830
88nuclear envelope reassembly (GO:0031468)2.94554754
89mitotic nuclear envelope reassembly (GO:0007084)2.94554754
90regulation of translation in response to stress (GO:0043555)2.94402619
91deoxyribonucleotide biosynthetic process (GO:0009263)2.94037721
92base-excision repair (GO:0006284)2.93585532
93mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92897751
94mast cell activation (GO:0045576)2.90504676
95histone exchange (GO:0043486)2.89417855
96negative regulation of protein ubiquitination (GO:0031397)2.88441525
97maturation of SSU-rRNA (GO:0030490)2.87215861
98DNA replication initiation (GO:0006270)2.87016780
99deoxyribose phosphate biosynthetic process (GO:0046385)2.86585544
1002-deoxyribonucleotide biosynthetic process (GO:0009265)2.86585544
101transcription-coupled nucleotide-excision repair (GO:0006283)2.85969237
102oxidative phosphorylation (GO:0006119)2.85564601
103regulation of ubiquitin-protein transferase activity (GO:0051438)2.83250519
104pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.83039258
105regulation of cellular amino acid metabolic process (GO:0006521)2.82940378
106de novo protein folding (GO:0006458)2.80548471
107DNA replication-independent nucleosome assembly (GO:0006336)2.80507750
108DNA replication-independent nucleosome organization (GO:0034724)2.80507750
109DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.79549910
110regulation of mitochondrial translation (GO:0070129)2.79381074
111negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.78806392
112misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.78793776
113mitotic recombination (GO:0006312)2.78573182
114viral mRNA export from host cell nucleus (GO:0046784)2.78311955
115mitochondrial RNA metabolic process (GO:0000959)2.77907749
116DNA catabolic process, exonucleolytic (GO:0000738)2.76197192
117protein targeting to mitochondrion (GO:0006626)2.75929708
118positive regulation of cell cycle arrest (GO:0071158)2.75355067
119antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75000153
120regulation of translational fidelity (GO:0006450)2.74080808
121de novo posttranslational protein folding (GO:0051084)2.73830627
122negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.73785151
123signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73686241
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73686241
125mitotic nuclear envelope disassembly (GO:0007077)2.73635404
126organelle disassembly (GO:1903008)2.73573196
127deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.73491410
128guanosine-containing compound biosynthetic process (GO:1901070)2.72365250
129pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.72184765
130nucleobase-containing small molecule interconversion (GO:0015949)2.71865441
131peptidyl-arginine methylation (GO:0018216)2.71808729
132peptidyl-arginine N-methylation (GO:0035246)2.71808729
133GDP-mannose metabolic process (GO:0019673)2.71266713
134pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.70402993
135protein localization to kinetochore (GO:0034501)2.69905275
136regulation of B cell apoptotic process (GO:0002902)2.69828358
137telomere maintenance via telomere lengthening (GO:0010833)2.69740364
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.68994135
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.68994135
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.68994135
141peptidyl-histidine modification (GO:0018202)2.68882258
142G1/S transition of mitotic cell cycle (GO:0000082)2.68617801
143cell cycle G1/S phase transition (GO:0044843)2.68617801
144deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.68366820
145regulation of ligase activity (GO:0051340)2.68220673
1467-methylguanosine mRNA capping (GO:0006370)2.67639741
147transcription from mitochondrial promoter (GO:0006390)2.65560491
148DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.64873823
149folic acid metabolic process (GO:0046655)2.63987787
150mitotic sister chromatid segregation (GO:0000070)2.63428425
151pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.63293878
152dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.61788367
153regulation of double-strand break repair via homologous recombination (GO:0010569)2.61350110
154nucleotide-excision repair, DNA gap filling (GO:0006297)2.58766605
155proline biosynthetic process (GO:0006561)2.57598114
156tRNA metabolic process (GO:0006399)2.56891941
157RNA capping (GO:0036260)2.56706470
1587-methylguanosine RNA capping (GO:0009452)2.56706470
159nucleoside salvage (GO:0043174)2.55231151
160regulation of cellular amine metabolic process (GO:0033238)2.54582709
161nucleotide-sugar biosynthetic process (GO:0009226)2.54455096

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.58106106
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20923924
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.17766895
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.01964552
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.96275499
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93737403
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.37750603
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.32456443
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.27030574
10MYC_18358816_ChIP-ChIP_MESCs_Mouse3.22100730
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.10335675
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05175286
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.99327158
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81682974
15FOXP3_21729870_ChIP-Seq_TREG_Human2.63002988
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60283660
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.50610412
18XRN2_22483619_ChIP-Seq_HELA_Human2.46252804
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42937699
20VDR_23849224_ChIP-Seq_CD4+_Human2.39253511
21GABP_19822575_ChIP-Seq_HepG2_Human2.31159829
22* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.31059967
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29506535
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.26953536
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22721943
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.20409976
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.19980273
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19344380
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.17388307
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.15825537
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13698986
32DCP1A_22483619_ChIP-Seq_HELA_Human2.09106924
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04319812
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.91849082
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89512614
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86849866
37CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.84472548
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83971266
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78286825
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78090247
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76973746
42TTF2_22483619_ChIP-Seq_HELA_Human1.74755237
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72823100
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70231486
45CIITA_25753668_ChIP-Seq_RAJI_Human1.68560468
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66510286
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65298828
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65146667
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63006878
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58085456
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.54553849
52SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.52315417
53ZNF263_19887448_ChIP-Seq_K562_Human1.51880604
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48448328
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.46135875
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.43041512
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42778873
58CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27698476
59SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.27374884
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.26673292
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.25344620
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24608013
63CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21611886
64ELK1_19687146_ChIP-ChIP_HELA_Human1.19963129
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.19382420
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18246015
67CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18209099
68KDM5A_27292631_Chip-Seq_BREAST_Human1.18194730
69TBX5_21415370_ChIP-Seq_HL-1_Mouse1.14784757
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.14561673
71TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14342303
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14319512
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13620968
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12784213
75TFEB_21752829_ChIP-Seq_HELA_Human1.12710703
76AR_21909140_ChIP-Seq_LNCAP_Human1.12083340
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11523538
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10500468
79E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10195198
80PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09638784
81SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08499905
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08476980
83NANOG_21062744_ChIP-ChIP_HESCs_Human1.08087338
84CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06648385
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06272585
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.04824235
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04606504
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04497605
89MYC_18940864_ChIP-ChIP_HL60_Human1.03935859
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02801689
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01800714
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01716149
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99984614
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99562579
95MYC_22102868_ChIP-Seq_BL_Human0.98537490
96CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98300555
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98284981
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97115873
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96441221
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.96027057
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.95875897
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.95210704
103CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95074999
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.93718604
105CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92971606
106EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91753692
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91656544
108ELK1_22589737_ChIP-Seq_MCF10A_Human0.90742438
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.90518781
110VDR_21846776_ChIP-Seq_THP-1_Human0.88114519
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.87980721
112IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87418857
113CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86905558
114STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86361988
115GATA1_22025678_ChIP-Seq_K562_Human0.86144114
116CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85722522
117SPI1_23547873_ChIP-Seq_NB4_Human0.83813369
118ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.83585488
119FOXP1_21924763_ChIP-Seq_HESCs_Human0.81631833
120CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.79511637
121ELF5_23300383_ChIP-Seq_T47D_Human0.79377692
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.77380947

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.12030109
2MP0008058_abnormal_DNA_repair3.79852476
3MP0010094_abnormal_chromosome_stability3.48364570
4MP0001853_heart_inflammation3.22512276
5MP0003111_abnormal_nucleus_morphology3.20674290
6MP0002877_abnormal_melanocyte_morpholog3.13157571
7MP0004147_increased_porphyrin_level3.00458951
8MP0008007_abnormal_cellular_replicative2.97373223
9MP0008877_abnormal_DNA_methylation2.93518933
10MP0008260_abnormal_autophagy2.91980129
11MP0003693_abnormal_embryo_hatching2.85643667
12MP0005058_abnormal_lysosome_morphology2.75967418
13MP0004036_abnormal_muscle_relaxation2.71560422
14MP0002396_abnormal_hematopoietic_system2.62621262
15MP0002254_reproductive_system_inflammat2.43966255
16MP0003077_abnormal_cell_cycle2.38126442
17MP0006036_abnormal_mitochondrial_physio2.30225518
18MP0003183_abnormal_peptide_metabolism2.26526407
19MP0004957_abnormal_blastocyst_morpholog2.15250375
20MP0002638_abnormal_pupillary_reflex2.08685941
21MP0003879_abnormal_hair_cell2.08475051
22MP0003806_abnormal_nucleotide_metabolis2.07392017
23MP0009840_abnormal_foam_cell2.03044013
24MP0003123_paternal_imprinting1.98166497
25MP0001529_abnormal_vocalization1.88760148
26MP0000465_gastrointestinal_hemorrhage1.80037635
27MP0001730_embryonic_growth_arrest1.79696981
28MP0008932_abnormal_embryonic_tissue1.75190367
29MP0001188_hyperpigmentation1.75134521
30MP0006276_abnormal_autonomic_nervous1.72148020
31MP0003315_abnormal_perineum_morphology1.64864150
32MP0003300_gastrointestinal_ulcer1.63127136
33MP0003122_maternal_imprinting1.57723865
34MP0003656_abnormal_erythrocyte_physiolo1.57431826
35MP0003436_decreased_susceptibility_to1.56786464
36MP0000490_abnormal_crypts_of1.56253148
37MP0003191_abnormal_cellular_cholesterol1.56083655
38MP0002148_abnormal_hypersensitivity_rea1.49991624
39MP0005670_abnormal_white_adipose1.48045615
40MP0006035_abnormal_mitochondrial_morpho1.43996860
41MP0000358_abnormal_cell_content/1.42187893
42MP0000372_irregular_coat_pigmentation1.40939100
43MP0003943_abnormal_hepatobiliary_system1.40330579
44MP0003186_abnormal_redox_activity1.40309522
45MP0010030_abnormal_orbit_morphology1.39627293
46MP0005084_abnormal_gallbladder_morpholo1.35573352
47MP0000604_amyloidosis1.34094589
48MP0003880_abnormal_central_pattern1.31273006
49MP0004808_abnormal_hematopoietic_stem1.30041674
50MP0000749_muscle_degeneration1.28088898
51MP0001697_abnormal_embryo_size1.26489346
52MP0004233_abnormal_muscle_weight1.26037443
53MP0005075_abnormal_melanosome_morpholog1.24514128
54MP0000350_abnormal_cell_proliferation1.20515864
55MP0005365_abnormal_bile_salt1.20251054
56MP0001835_abnormal_antigen_presentation1.18332765
57MP0003221_abnormal_cardiomyocyte_apopto1.17107251
58MP0002736_abnormal_nociception_after1.15891971
59MP0009278_abnormal_bone_marrow1.15558658
60MP0005464_abnormal_platelet_physiology1.12722202
61MP0003718_maternal_effect1.12204110
62MP0002080_prenatal_lethality1.11370384
63MP0004859_abnormal_synaptic_plasticity1.10312280
64MP0002837_dystrophic_cardiac_calcinosis1.09592965
65MP0004133_heterotaxia1.06184360
66MP0005266_abnormal_metabolism1.06063783
67MP0002234_abnormal_pharynx_morphology1.05742355
68MP0009672_abnormal_birth_weight1.04513655
69MP0001764_abnormal_homeostasis1.01752732
70MP0001346_abnormal_lacrimal_gland1.01517966
71MP0005501_abnormal_skin_physiology1.00526177
72MP0001968_abnormal_touch/_nociception0.99156458
73MP0002269_muscular_atrophy0.98372731
74MP0000015_abnormal_ear_pigmentation0.97693657
75MP0005384_cellular_phenotype0.97491532
76MP0010329_abnormal_lipoprotein_level0.96372488
77MP0009333_abnormal_splenocyte_physiolog0.96305207
78MP0008004_abnormal_stomach_pH0.95546358
79MP0000747_muscle_weakness0.94935010
80MP0004130_abnormal_muscle_cell0.93959713
81MP0001485_abnormal_pinna_reflex0.93618761
82MP0003172_abnormal_lysosome_physiology0.92618468
83MP0008875_abnormal_xenobiotic_pharmacok0.91944063
84MP0004043_abnormal_pH_regulation0.91081988
85MP0002722_abnormal_immune_system0.89340840
86MP0002909_abnormal_adrenal_gland0.89330327
87MP0000609_abnormal_liver_physiology0.88139455
88MP0009785_altered_susceptibility_to0.87431627
89MP0000689_abnormal_spleen_morphology0.87087256
90MP0005451_abnormal_body_composition0.86544896
91MP0003786_premature_aging0.85832447
92MP0000313_abnormal_cell_death0.84845019
93MP0000613_abnormal_salivary_gland0.83925608
94MP0005385_cardiovascular_system_phenoty0.83555961
95MP0001544_abnormal_cardiovascular_syste0.83555961
96MP0001661_extended_life_span0.82581438
97MP0002405_respiratory_system_inflammati0.80862724
98MP0010352_gastrointestinal_tract_polyps0.80036913
99MP0005621_abnormal_cell_physiology0.79441089
100MP0004811_abnormal_neuron_physiology0.79250874
101MP0005380_embryogenesis_phenotype0.78330787
102MP0001672_abnormal_embryogenesis/_devel0.78330787
103MP0003121_genomic_imprinting0.77001792
104MP0002429_abnormal_blood_cell0.75830319
105MP0002210_abnormal_sex_determination0.75810455
106MP0005165_increased_susceptibility_to0.75539426
107MP0000759_abnormal_skeletal_muscle0.74818377
108MP0005408_hypopigmentation0.74744835
109MP0008873_increased_physiological_sensi0.74513013
110MP0009697_abnormal_copulation0.73713070
111MP0003635_abnormal_synaptic_transmissio0.73656844
112MP0000003_abnormal_adipose_tissue0.72104204
113MP0000598_abnormal_liver_morphology0.71797261
114MP0010155_abnormal_intestine_physiology0.70398717
115MP0002970_abnormal_white_adipose0.70056518
116MP0003646_muscle_fatigue0.69739459
117MP0000371_diluted_coat_color0.69368304
118MP0002796_impaired_skin_barrier0.69141430
119MP0002272_abnormal_nervous_system0.68973190
120MP0002398_abnormal_bone_marrow0.68823912
121MP0009780_abnormal_chondrocyte_physiolo0.68630460
122MP0003119_abnormal_digestive_system0.68579685
123MP0003984_embryonic_growth_retardation0.68327626
124MP0002653_abnormal_ependyma_morphology0.68227036
125MP0001119_abnormal_female_reproductive0.67568102
126MP0009764_decreased_sensitivity_to0.67179717
127MP0000703_abnormal_thymus_morphology0.66871501
128MP0001216_abnormal_epidermal_layer0.66561898
129MP0002085_abnormal_embryonic_tissue0.66068964
130MP0001243_abnormal_dermal_layer0.65844698
131MP0002972_abnormal_cardiac_muscle0.65574650
132MP0008469_abnormal_protein_level0.65520328
133MP0006072_abnormal_retinal_apoptosis0.65389238
134MP0008789_abnormal_olfactory_epithelium0.65166028
135MP0002088_abnormal_embryonic_growth/wei0.64897837
136MP0001270_distended_abdomen0.64503457
137MP0005551_abnormal_eye_electrophysiolog0.64330063
138MP0001324_abnormal_eye_pigmentation0.64181213
139MP0002063_abnormal_learning/memory/cond0.64044791
140MP0002106_abnormal_muscle_physiology0.63960074
141MP0002019_abnormal_tumor_incidence0.63838839
142MP0003448_altered_tumor_morphology0.63707338
143MP0005330_cardiomyopathy0.62813908
144MP0002064_seizures0.62523239
145MP0000653_abnormal_sex_gland0.62224582
146MP0003137_abnormal_impulse_conducting0.61474225
147MP0001145_abnormal_male_reproductive0.60998285
148MP0002139_abnormal_hepatobiliary_system0.59895281
149MP0004087_abnormal_muscle_fiber0.59520885
150MP0002184_abnormal_innervation0.58536327
151MP0001929_abnormal_gametogenesis0.57928945
152MP0002075_abnormal_coat/hair_pigmentati0.57520586
153MP0002873_normal_phenotype0.57333104
154MP0002161_abnormal_fertility/fecundity0.56962877
155MP0009763_increased_sensitivity_to0.56846186

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)6.91158656
2Anterior segment dysgenesis (HP:0007700)5.77501543
3Ependymoma (HP:0002888)5.51593133
4Type II lissencephaly (HP:0007260)5.39366127
5Increased serum pyruvate (HP:0003542)4.81384426
6Abnormality of glycolysis (HP:0004366)4.81384426
7Agnosia (HP:0010524)4.63021802
8Bundle branch block (HP:0011710)4.25504679
9Type I transferrin isoform profile (HP:0003642)3.95077628
10Cerebral hypomyelination (HP:0006808)3.72937223
11Reduced antithrombin III activity (HP:0001976)3.68611298
12Abnormality of the astrocytes (HP:0100707)3.64996227
13Astrocytoma (HP:0009592)3.64996227
14Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.63697896
15Abnormal protein N-linked glycosylation (HP:0012347)3.63697896
16Abnormal protein glycosylation (HP:0012346)3.63697896
17Abnormal glycosylation (HP:0012345)3.63697896
18Aplasia/Hypoplasia of the brainstem (HP:0007362)3.57491293
19Hypoplasia of the brainstem (HP:0002365)3.57491293
20Prostate neoplasm (HP:0100787)3.55858332
21Medulloblastoma (HP:0002885)3.55225853
22Abnormality of the anterior horn cell (HP:0006802)3.43224396
23Degeneration of anterior horn cells (HP:0002398)3.43224396
24Hepatocellular necrosis (HP:0001404)3.33175759
25Lissencephaly (HP:0001339)3.26618411
26Hyperalaninemia (HP:0003348)3.19924020
27Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.19924020
28Abnormality of alanine metabolism (HP:0010916)3.19924020
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.18739850
30Microvesicular hepatic steatosis (HP:0001414)3.18395130
31Hepatic necrosis (HP:0002605)3.11254837
32Rough bone trabeculation (HP:0100670)3.10956681
33Visual hallucinations (HP:0002367)3.05868328
34Vacuolated lymphocytes (HP:0001922)2.98460190
35Vertebral compression fractures (HP:0002953)2.98250563
36Neuroendocrine neoplasm (HP:0100634)2.97046020
37Abnormal gallbladder physiology (HP:0012438)2.93104577
38Cholecystitis (HP:0001082)2.93104577
39Buphthalmos (HP:0000557)2.91567116
40Glioma (HP:0009733)2.90989214
41Hypoplasia of the capital femoral epiphysis (HP:0003090)2.90787637
42Neoplasm of the peripheral nervous system (HP:0100007)2.89852908
43Severe muscular hypotonia (HP:0006829)2.89687909
44CNS hypomyelination (HP:0003429)2.88153350
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.87929315
46Multiple enchondromatosis (HP:0005701)2.80369063
47Spinal rigidity (HP:0003306)2.79268417
48Reduced subcutaneous adipose tissue (HP:0003758)2.68092854
49Abnormal trabecular bone morphology (HP:0100671)2.65988113
50Lipid accumulation in hepatocytes (HP:0006561)2.61646874
51Neoplasm of the rectum (HP:0100743)2.61541820
52Increased cerebral lipofuscin (HP:0011813)2.60915462
53Pancytopenia (HP:0001876)2.60149108
54Rhabdomyosarcoma (HP:0002859)2.58026745
55Increased hepatocellular lipid droplets (HP:0006565)2.57469127
56Pancreatic islet-cell hyperplasia (HP:0004510)2.57366449
57Focal motor seizures (HP:0011153)2.56554953
58Hypokinesia (HP:0002375)2.47874965
59Mitochondrial inheritance (HP:0001427)2.46287375
60Testicular atrophy (HP:0000029)2.46137276
61Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.44429649
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.44429649
63Emotional lability (HP:0000712)2.44239801
64Symptomatic seizures (HP:0011145)2.43064499
65Abnormal mitochondria in muscle tissue (HP:0008316)2.39882020
66Increased CSF lactate (HP:0002490)2.39738515
67Abnormality of liposaccharide metabolism (HP:0010968)2.37802417
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.37802417
69Abnormality of glycolipid metabolism (HP:0010969)2.37802417
70Unsteady gait (HP:0002317)2.36755168
71Acute necrotizing encephalopathy (HP:0006965)2.36648067
72Prominent metopic ridge (HP:0005487)2.33869903
73CNS demyelination (HP:0007305)2.31968835
74Postnatal microcephaly (HP:0005484)2.30019164
75Congenital glaucoma (HP:0001087)2.29654431
76Hypoplasia of the pons (HP:0012110)2.29041982
77Inability to walk (HP:0002540)2.27253978
78Increased intramyocellular lipid droplets (HP:0012240)2.26286101
79Pheochromocytoma (HP:0002666)2.26235386
80Progressive inability to walk (HP:0002505)2.25978783
81Progressive muscle weakness (HP:0003323)2.25880467
82Birth length less than 3rd percentile (HP:0003561)2.24970665
83Spastic paraparesis (HP:0002313)2.24841047
84Chromosomal breakage induced by crosslinking agents (HP:0003221)2.23069739
85Delayed CNS myelination (HP:0002188)2.22899168
86Intellectual disability, profound (HP:0002187)2.22830326
87Increased serum lactate (HP:0002151)2.22494675
88Secondary amenorrhea (HP:0000869)2.21329154
89Absence seizures (HP:0002121)2.20513320
9011 pairs of ribs (HP:0000878)2.20300668
91Increased muscle lipid content (HP:0009058)2.20106118
92Cerebellar hypoplasia (HP:0001321)2.19760293
93Abnormality of the anterior chamber (HP:0000593)2.17985560
94Hypoglycemic seizures (HP:0002173)2.17662554
95Poor eye contact (HP:0000817)2.15775110
96Amaurosis fugax (HP:0100576)2.15477322
97Microretrognathia (HP:0000308)2.12952298
98Entropion (HP:0000621)2.11618629
99Atrophy/Degeneration involving motor neurons (HP:0007373)2.11285127
100Loss of speech (HP:0002371)2.09745689
101Neoplasm of striated muscle (HP:0009728)2.09603643
102Neuroblastic tumors (HP:0004376)2.08068958
103Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.08068958
104Neuroblastoma (HP:0003006)2.08068958
105Primitive neuroectodermal tumor (HP:0030065)2.08068958
106Abnormality of the prostate (HP:0008775)2.07006549
107Retinal dysplasia (HP:0007973)2.07000492
108Increased IgM level (HP:0003496)2.06876161
109Abnormality of methionine metabolism (HP:0010901)2.06746987
110Acute encephalopathy (HP:0006846)2.05072871
111Trismus (HP:0000211)2.03131422
112Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01180934
113Oral leukoplakia (HP:0002745)2.00948261
114Muscular dystrophy (HP:0003560)1.99832316
115Neoplasm of the small intestine (HP:0100833)1.99541915
116Heart block (HP:0012722)1.97950728
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97706434
118Sparse eyelashes (HP:0000653)1.97647187
119Abnormality of the preputium (HP:0100587)1.97378581
120Renal Fanconi syndrome (HP:0001994)1.97313037
121Opisthotonus (HP:0002179)1.96430319
122Absent epiphyses (HP:0010577)1.96407317
123Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96407317
124Lactic acidosis (HP:0003128)1.96274973
125Fasciculations (HP:0002380)1.95901277
126Abnormality of the umbilical cord (HP:0010881)1.95293700
127Abnormality of the pons (HP:0007361)1.94986455
128Upper limb muscle weakness (HP:0003484)1.94550350
129Abnormality of the intrinsic pathway (HP:0010989)1.92484016
130Gastrointestinal stroma tumor (HP:0100723)1.90219452
131Squamous cell carcinoma (HP:0002860)1.90035210
132Hyperinsulinemic hypoglycemia (HP:0000825)1.89398083
133Generalized muscle weakness (HP:0003324)1.89324293
134Cortical dysplasia (HP:0002539)1.88814954
135Hepatosplenomegaly (HP:0001433)1.88732956
136Premature ovarian failure (HP:0008209)1.88154681
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88026037
138Horseshoe kidney (HP:0000085)1.87862292
139Biliary tract neoplasm (HP:0100574)1.87772257
140Abnormality of the vitreous humor (HP:0004327)1.87055894
141Neoplasm of the adrenal gland (HP:0100631)1.86855972
142Respiratory difficulties (HP:0002880)1.85130101
143Death in infancy (HP:0001522)1.84492910
144Cerebral edema (HP:0002181)1.84474977
145Ragged-red muscle fibers (HP:0003200)1.83552711
146Abnormal atrioventricular conduction (HP:0005150)1.83495152
147Autoimmune hemolytic anemia (HP:0001890)1.82373404
148Nonimmune hydrops fetalis (HP:0001790)1.82367121
149Abnormalities of placenta or umbilical cord (HP:0001194)1.79620144
150Macroglossia (HP:0000158)1.79505292
151Chromsome breakage (HP:0040012)1.79381733
152Hypoplastic pelvis (HP:0008839)1.79204183
153Progressive macrocephaly (HP:0004481)1.79046954
154Broad distal phalanx of finger (HP:0009836)1.78724693
155Delusions (HP:0000746)1.78313186
156Combined immunodeficiency (HP:0005387)1.78211390
157Polygenic inheritance (HP:0010982)1.76606006
158Myopathic facies (HP:0002058)1.76569783
159Oligomenorrhea (HP:0000876)1.76438733
160Exercise intolerance (HP:0003546)1.76150299
161Growth hormone excess (HP:0000845)1.75719649
162Acute lymphatic leukemia (HP:0006721)1.74975353
163Tongue fasciculations (HP:0001308)1.74758511
164Shoulder girdle muscle weakness (HP:0003547)1.74727136
165Abnormality of the metopic suture (HP:0005556)1.74541601
166Reticulocytopenia (HP:0001896)1.74336732
167Limb hypertonia (HP:0002509)1.74143995
168Hypergonadotropic hypogonadism (HP:0000815)1.73529588
169Self-mutilation (HP:0000742)1.73361214
170Hypoglycemic coma (HP:0001325)1.71647952
171Angiofibromas (HP:0010615)1.71060746
172Adenoma sebaceum (HP:0009720)1.71060746
173Aplastic anemia (HP:0001915)1.68871468
174Dialeptic seizures (HP:0011146)1.68732479
175Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.68084889
176Neoplasm of the colon (HP:0100273)1.67758793
177Carpal bone hypoplasia (HP:0001498)1.65970033
178Abnormality of the pupil (HP:0000615)1.64303662
179Limb-girdle muscle atrophy (HP:0003797)1.64160452

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG8.45701826
2EIF2AK14.06792417
3VRK23.99230916
4STK163.32692626
5SIK33.05857904
6BUB13.02503063
7NEK12.76238377
8INSRR2.60847590
9FLT32.52877504
10CCNB12.47602058
11TRIM282.34077784
12MAP3K102.20533299
13BCKDK2.20348333
14KIT2.10120453
15SMG12.07844198
16IRAK32.01725162
17SRPK11.99726586
18PASK1.88278380
19PDK31.80121693
20PDK41.80121693
21MAP3K121.72835797
22TESK11.67773016
23ZAK1.60928995
24BRAF1.56868022
25PIK3CA1.52859795
26ARAF1.45793602
27TSSK61.44736135
28MAP3K111.41580001
29TGFBR11.40546309
30EIF2AK31.40117445
31TLK11.36740109
32NME11.34923340
33ICK1.33724739
34EPHA21.32030949
35PRPF4B1.32023470
36WEE11.30587821
37BCR1.17349633
38CDC71.11185072
39MAP3K91.09509412
40SCYL21.08974841
41VRK11.06548215
42ABL21.06417634
43MAP2K61.04885081
44MST41.02697739
45PBK1.02666885
46ACVR1B1.01709829
47KSR11.00955299
48LIMK10.99747614
49MAP2K30.97241103
50MINK10.95460192
51MAP3K140.92609576
52PLK10.91651716
53STK100.91456281
54CSNK1A1L0.90773369
55CDK180.88377397
56MAP4K20.86529319
57MAP3K30.83635239
58DAPK10.83326513
59ERN10.81447733
60MAP3K130.80560243
61MATK0.80444074
62KDR0.78512879
63TESK20.78278847
64CDK80.78026842
65CSF1R0.75788125
66CDK190.75186857
67CLK10.74775857
68PAK40.73289976
69CDK150.72294726
70CSNK1G10.70540943
71PDK20.69861053
72TBK10.69538695
73CDK11A0.69423245
74TAF10.69054846
75PLK40.65648001
76EIF2AK20.65588031
77PIM20.64263330
78MST1R0.62709639
79CDK140.62397306
80NTRK30.61397904
81CDK90.58826249
82MARK10.58387632
83CSNK1G20.56911260
84LMTK20.55804702
85AURKA0.55607479
86NUAK10.55445961
87ATM0.54147362
88PLK30.53443292
89FER0.52438240
90ATR0.51623091
91STK40.51531996
92BRSK10.51354727
93EPHB10.50553561
94NEK20.50297555
95TAOK20.48910143
96DAPK30.47333699
97MYLK0.45041461
98RPS6KC10.44962957
99RPS6KL10.44962957
100DYRK20.44797513
101JAK30.42893001
102TIE10.42376682
103CDK40.42232114
104AKT20.41126401
105RPS6KA20.40540363
106PRKCI0.40087079
107RPS6KA40.39998156
108RPS6KA60.39304566
109NME20.37790264
110UHMK10.37331679
111ERBB40.36559389
112BRSK20.36558716
113CHEK10.35543512
114DAPK20.34924722
115AKT30.33057451
116CSNK2A20.32902741
117PAK10.32686106
118ALK0.32177258
119TEC0.31129965
120CDK120.29783244
121MAP3K80.29751444
122MAPK110.29233861
123TGFBR20.28681232
124DYRK30.25989393
125MAPK40.25957726
126CSNK1E0.25518627
127TTK0.24447114
128CSNK2A10.22228255
129AURKB0.20228393
130PRKG20.20132128
131RPS6KB10.18345236
132CDK70.16548463
133PRKD30.16486933
134PAK30.15674817
135CSNK1G30.14344594
136CDK10.14315658
137CDK20.14023737
138PRKCG0.11009541
139MAP3K50.10246617
140CAMKK20.10019107
141CHEK20.08641093

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.83853621
2Mismatch repair_Homo sapiens_hsa034303.62098200
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.07023724
4DNA replication_Homo sapiens_hsa030303.05024814
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00152791
6Spliceosome_Homo sapiens_hsa030402.44945980
7Sulfur relay system_Homo sapiens_hsa041222.44261618
8RNA polymerase_Homo sapiens_hsa030202.42725760
9Base excision repair_Homo sapiens_hsa034102.31626930
10Fatty acid elongation_Homo sapiens_hsa000622.30777196
11Ribosome_Homo sapiens_hsa030102.26404064
12Selenocompound metabolism_Homo sapiens_hsa004502.25947385
13Folate biosynthesis_Homo sapiens_hsa007902.22973141
14Pyrimidine metabolism_Homo sapiens_hsa002402.13968415
15Parkinsons disease_Homo sapiens_hsa050122.12547195
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.07280832
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.97422161
18RNA transport_Homo sapiens_hsa030131.94617365
19Biosynthesis of amino acids_Homo sapiens_hsa012301.83806946
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77597764
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.76861204
22One carbon pool by folate_Homo sapiens_hsa006701.72979133
23Oxidative phosphorylation_Homo sapiens_hsa001901.71414863
24Carbon metabolism_Homo sapiens_hsa012001.67948082
25Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.67794633
26Homologous recombination_Homo sapiens_hsa034401.53580503
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47165994
28Central carbon metabolism in cancer_Homo sapiens_hsa052301.46339513
29Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44454308
30Pyruvate metabolism_Homo sapiens_hsa006201.38631416
31Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.35937543
32Purine metabolism_Homo sapiens_hsa002301.31176655
33Other glycan degradation_Homo sapiens_hsa005111.30394770
34Acute myeloid leukemia_Homo sapiens_hsa052211.27299771
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.24961352
36Huntingtons disease_Homo sapiens_hsa050161.24712660
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22984105
38Steroid biosynthesis_Homo sapiens_hsa001001.22388074
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18781179
40Nucleotide excision repair_Homo sapiens_hsa034201.15569401
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13383171
42Fanconi anemia pathway_Homo sapiens_hsa034601.08064533
43Fructose and mannose metabolism_Homo sapiens_hsa000511.06591210
44Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04690806
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.01798078
46Cell cycle_Homo sapiens_hsa041100.99460782
47Pentose phosphate pathway_Homo sapiens_hsa000300.97837264
48Cardiac muscle contraction_Homo sapiens_hsa042600.97772273
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96773258
50Fatty acid metabolism_Homo sapiens_hsa012120.95900864
51Alzheimers disease_Homo sapiens_hsa050100.95821992
52Epstein-Barr virus infection_Homo sapiens_hsa051690.95619742
53Glutathione metabolism_Homo sapiens_hsa004800.93584506
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92665964
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.91964040
56p53 signaling pathway_Homo sapiens_hsa041150.89756446
57Sulfur metabolism_Homo sapiens_hsa009200.89142115
58Non-small cell lung cancer_Homo sapiens_hsa052230.88451849
59RNA degradation_Homo sapiens_hsa030180.82641576
60Basal transcription factors_Homo sapiens_hsa030220.80894525
61Propanoate metabolism_Homo sapiens_hsa006400.80385328
62Lysosome_Homo sapiens_hsa041420.79700697
63Protein export_Homo sapiens_hsa030600.78952755
64Peroxisome_Homo sapiens_hsa041460.78872860
65Oocyte meiosis_Homo sapiens_hsa041140.77783388
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77330875
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74589887
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73120992
69Synaptic vesicle cycle_Homo sapiens_hsa047210.69399008
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68517827
71Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66754711
72mRNA surveillance pathway_Homo sapiens_hsa030150.65626072
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.65239699
74Viral carcinogenesis_Homo sapiens_hsa052030.63984374
75Endometrial cancer_Homo sapiens_hsa052130.62816932
76Primary immunodeficiency_Homo sapiens_hsa053400.61688745
77HIF-1 signaling pathway_Homo sapiens_hsa040660.61113826
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60260020
79Colorectal cancer_Homo sapiens_hsa052100.60072627
80mTOR signaling pathway_Homo sapiens_hsa041500.59537124
81Vitamin B6 metabolism_Homo sapiens_hsa007500.58578012
82Non-homologous end-joining_Homo sapiens_hsa034500.57175647
83Thyroid cancer_Homo sapiens_hsa052160.55107616
84Galactose metabolism_Homo sapiens_hsa000520.55053313
85Arginine and proline metabolism_Homo sapiens_hsa003300.54741807
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54737797
87VEGF signaling pathway_Homo sapiens_hsa043700.50918693
88Legionellosis_Homo sapiens_hsa051340.50776049
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49817175
90Shigellosis_Homo sapiens_hsa051310.49365998
91Vibrio cholerae infection_Homo sapiens_hsa051100.48686765
92Apoptosis_Homo sapiens_hsa042100.47582283
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.47213798
94N-Glycan biosynthesis_Homo sapiens_hsa005100.47133242
95Type II diabetes mellitus_Homo sapiens_hsa049300.46733568
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46465594
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.44361437
98Renal cell carcinoma_Homo sapiens_hsa052110.44315938
99Metabolic pathways_Homo sapiens_hsa011000.42902329
100Fatty acid degradation_Homo sapiens_hsa000710.42673164
101Herpes simplex infection_Homo sapiens_hsa051680.40649282
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40610183
103Systemic lupus erythematosus_Homo sapiens_hsa053220.40268428
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38311478
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38065516
106Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37156345
107Regulation of autophagy_Homo sapiens_hsa041400.36659214
108Measles_Homo sapiens_hsa051620.36077381
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35101973
110Tyrosine metabolism_Homo sapiens_hsa003500.35026352
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.34821423
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34770500
113AMPK signaling pathway_Homo sapiens_hsa041520.34160693
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33289057
115HTLV-I infection_Homo sapiens_hsa051660.32456938
116Phenylalanine metabolism_Homo sapiens_hsa003600.30457148
117Sphingolipid metabolism_Homo sapiens_hsa006000.29548077
118Butanoate metabolism_Homo sapiens_hsa006500.29202847
119Caffeine metabolism_Homo sapiens_hsa002320.29014267
120Vitamin digestion and absorption_Homo sapiens_hsa049770.28107920
121Melanoma_Homo sapiens_hsa052180.27936026
122Alcoholism_Homo sapiens_hsa050340.27380352
123Glioma_Homo sapiens_hsa052140.22601421
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22022256
125Arginine biosynthesis_Homo sapiens_hsa002200.20582555
126Rheumatoid arthritis_Homo sapiens_hsa053230.20381025
127Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20163588
128Tryptophan metabolism_Homo sapiens_hsa003800.19703139
129Bladder cancer_Homo sapiens_hsa052190.19035906
130beta-Alanine metabolism_Homo sapiens_hsa004100.17323752

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