AARD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of meiosis I (GO:0060631)9.25986274
2sex differentiation (GO:0007548)8.48466969
3male sex determination (GO:0030238)8.18550762
4piRNA metabolic process (GO:0034587)7.73722131
5regulation of gonadotropin secretion (GO:0032276)7.25505669
6fusion of sperm to egg plasma membrane (GO:0007342)6.73699976
7anatomical structure regression (GO:0060033)6.53818568
8synaptonemal complex assembly (GO:0007130)6.32348201
9oocyte development (GO:0048599)6.18986108
10synaptonemal complex organization (GO:0070193)5.92728840
11glomerular basement membrane development (GO:0032836)5.71481307
12behavioral response to nicotine (GO:0035095)5.58626089
13male meiosis (GO:0007140)5.51698707
14DNA methylation involved in gamete generation (GO:0043046)5.50054605
15poly(A)+ mRNA export from nucleus (GO:0016973)5.32764475
16Leydig cell differentiation (GO:0033327)5.21018025
17ovulation cycle (GO:0042698)5.19473251
18response to misfolded protein (GO:0051788)5.16504765
19negative regulation of meiosis (GO:0045835)5.03705064
20plasma membrane fusion (GO:0045026)4.99082572
21regulation of female gonad development (GO:2000194)4.78786744
22astrocyte development (GO:0014002)4.76861343
23macroautophagy (GO:0016236)4.73845534
24negative regulation of macrophage differentiation (GO:0045650)4.68383825
25positive regulation of meiosis (GO:0045836)4.62310772
26positive regulation of meiotic cell cycle (GO:0051446)4.25123555
27positive regulation of reproductive process (GO:2000243)4.22042918
28fucose catabolic process (GO:0019317)4.16578900
29L-fucose metabolic process (GO:0042354)4.16578900
30L-fucose catabolic process (GO:0042355)4.16578900
31DNA deamination (GO:0045006)4.10920819
32hemoglobin metabolic process (GO:0020027)4.08452062
33negative regulation of telomere maintenance (GO:0032205)4.00892540
34histone H4-K8 acetylation (GO:0043982)4.00740526
35histone H4-K5 acetylation (GO:0043981)4.00740526
36glial cell proliferation (GO:0014009)3.96385657
37germ cell migration (GO:0008354)3.95998611
38apoptotic cell clearance (GO:0043277)3.91380972
39cornea development in camera-type eye (GO:0061303)3.87349735
40histone H4-K12 acetylation (GO:0043983)3.83993367
41embryonic foregut morphogenesis (GO:0048617)3.81890264
42water-soluble vitamin biosynthetic process (GO:0042364)3.79948154
43chromosome organization involved in meiosis (GO:0070192)3.77597558
44response to pheromone (GO:0019236)3.75804003
45receptor guanylyl cyclase signaling pathway (GO:0007168)3.75017155
46meiotic nuclear division (GO:0007126)3.69474848
47protein complex biogenesis (GO:0070271)3.68063106
48male meiosis I (GO:0007141)3.64664365
49auditory receptor cell stereocilium organization (GO:0060088)3.57298904
50respiratory chain complex IV assembly (GO:0008535)3.55591164
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.55243821
52mitochondrial respiratory chain complex I assembly (GO:0032981)3.55243821
53NADH dehydrogenase complex assembly (GO:0010257)3.55243821
54positive regulation of receptor biosynthetic process (GO:0010870)3.54288913
55energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51697794
56ATP synthesis coupled proton transport (GO:0015986)3.51697794
57gene silencing by RNA (GO:0031047)3.50451493
58diaphragm development (GO:0060539)3.44673287
59mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.41700210
60platelet dense granule organization (GO:0060155)3.41549164
61Sertoli cell development (GO:0060009)3.41476821
62female gamete generation (GO:0007292)3.40421862
63detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39840833
64mitochondrial respiratory chain complex assembly (GO:0033108)3.38961375
65limb bud formation (GO:0060174)3.35106741
66epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.35105538
67mitotic G1 DNA damage checkpoint (GO:0031571)3.34563100
68kynurenine metabolic process (GO:0070189)3.34439166
69vagina development (GO:0060068)3.28437635
70oogenesis (GO:0048477)3.26564831
71positive regulation of response to oxidative stress (GO:1902884)3.26543985
72positive regulation of cellular response to oxidative stress (GO:1900409)3.26543985
73indolalkylamine metabolic process (GO:0006586)3.26378126
74peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.25049998
75cytochrome complex assembly (GO:0017004)3.24316320
76natural killer cell differentiation (GO:0001779)3.22033889
77indole-containing compound catabolic process (GO:0042436)3.20675711
78indolalkylamine catabolic process (GO:0046218)3.20675711
79tryptophan catabolic process (GO:0006569)3.20675711
80preassembly of GPI anchor in ER membrane (GO:0016254)3.20352592
81replication fork processing (GO:0031297)3.19983593
82protein-cofactor linkage (GO:0018065)3.17135956
83mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16707671
84histone H3-K36 demethylation (GO:0070544)3.15310729
85G1 DNA damage checkpoint (GO:0044783)3.12385123
86skeletal muscle organ development (GO:0060538)3.10547450
87ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.10442605
88histone H4-K16 acetylation (GO:0043984)3.10155499
89mitotic chromosome condensation (GO:0007076)3.09761339
90protein polyglutamylation (GO:0018095)3.06423453
91L-alpha-amino acid transmembrane transport (GO:1902475)3.05497915
92behavioral response to ethanol (GO:0048149)3.04742042
93mannosylation (GO:0097502)3.04534461
94germ cell development (GO:0007281)3.03913828
95negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.03368526
96adrenal gland development (GO:0030325)3.03008452
97inner ear receptor stereocilium organization (GO:0060122)3.02498755
98peptidyl-lysine dimethylation (GO:0018027)3.02123872
99gamma-aminobutyric acid transport (GO:0015812)3.01792473
100establishment of protein localization to mitochondrial membrane (GO:0090151)3.00767507
101regulation of nucleobase-containing compound transport (GO:0032239)3.00339385
102regulation of protein polyubiquitination (GO:1902914)2.99702566
103DNA alkylation (GO:0006305)2.99234211
104DNA methylation (GO:0006306)2.99234211
105regulation of nuclear cell cycle DNA replication (GO:0033262)2.97971291
106positive regulation of fatty acid transport (GO:2000193)2.97678801
107kidney morphogenesis (GO:0060993)2.97114582
108positive regulation of macrophage cytokine production (GO:0060907)2.96377748
109dopamine transport (GO:0015872)2.91908136
110negative regulation of meiotic cell cycle (GO:0051447)2.91753991
111pseudouridine synthesis (GO:0001522)2.91398459
112male genitalia development (GO:0030539)2.91321457
113seminiferous tubule development (GO:0072520)2.90703960
114urogenital system development (GO:0001655)2.90118050
115somite development (GO:0061053)2.89045549
116ovulation cycle process (GO:0022602)2.86346655
117cellular ketone body metabolic process (GO:0046950)2.86204450
118cellular response to thyroid hormone stimulus (GO:0097067)2.85697254
119meiosis I (GO:0007127)2.84821683
120positive regulation of renal sodium excretion (GO:0035815)2.84418640
121histone H3-K9 demethylation (GO:0033169)2.83421822
122mitotic G1/S transition checkpoint (GO:0044819)2.83175033
123tryptophan metabolic process (GO:0006568)2.82411170
124detection of light stimulus involved in visual perception (GO:0050908)2.81928306
125detection of light stimulus involved in sensory perception (GO:0050962)2.81928306
126axoneme assembly (GO:0035082)2.81914382
127regulation of action potential (GO:0098900)2.81033695
128establishment of apical/basal cell polarity (GO:0035089)2.81018198
129GPI anchor metabolic process (GO:0006505)2.80627376
130fat-soluble vitamin catabolic process (GO:0042363)2.80570634
131vitamin catabolic process (GO:0009111)2.80570634
132regulation of hexokinase activity (GO:1903299)2.80039060
133regulation of glucokinase activity (GO:0033131)2.80039060
134gene silencing (GO:0016458)2.79070736
135epithelial cell fate commitment (GO:0072148)2.78727123
136retinal cone cell development (GO:0046549)2.78629076
137recombinational repair (GO:0000725)2.78538363
138positive regulation of urine volume (GO:0035810)2.78331946
139double-strand break repair via homologous recombination (GO:0000724)2.77462966
140cellular process involved in reproduction in multicellular organism (GO:0022412)2.76658625
141negative regulation of mast cell activation (GO:0033004)2.75470776
142regulation of meiosis (GO:0040020)2.74138745
143nonmotile primary cilium assembly (GO:0035058)2.73923467
144female genitalia development (GO:0030540)2.73336737
145cellular response to interferon-alpha (GO:0035457)2.72125626
146epithelial cilium movement (GO:0003351)2.69678193
147myelin maintenance (GO:0043217)2.69138477
148basement membrane organization (GO:0071711)2.68690533
149protein K6-linked ubiquitination (GO:0085020)2.68462712
150regulation of cardioblast differentiation (GO:0051890)2.67493526
151growth hormone secretion (GO:0030252)2.67018151
152ubiquinone biosynthetic process (GO:0006744)2.66620401
153ketone body metabolic process (GO:1902224)2.65913436
154cellular response to leptin stimulus (GO:0044320)2.65809520
155endocardial cushion development (GO:0003197)2.65220653
156tRNA processing (GO:0008033)2.63974244
157glycerophospholipid catabolic process (GO:0046475)2.61527092
158negative regulation of erythrocyte differentiation (GO:0045647)2.61518118
159nuclear pore complex assembly (GO:0051292)2.61184675
160tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60221626
161RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60221626
162histone H2A acetylation (GO:0043968)2.60038027
163electron transport chain (GO:0022900)2.59699905
164regulation of hydrogen peroxide-induced cell death (GO:1903205)2.59500316
165reciprocal meiotic recombination (GO:0007131)2.58509712
166reciprocal DNA recombination (GO:0035825)2.58509712
167nephron epithelium morphogenesis (GO:0072088)2.57922677
168nephron tubule morphogenesis (GO:0072078)2.57922677
169negative regulation of reactive oxygen species metabolic process (GO:2000378)2.57248622
170cilium morphogenesis (GO:0060271)2.55983967
171synaptic transmission, cholinergic (GO:0007271)2.55403933
172nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54788783
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.54642569
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.54417227
175cellular response to ATP (GO:0071318)2.52563307
176sulfation (GO:0051923)2.52488930
177indole-containing compound metabolic process (GO:0042430)2.52468175
178regulation of telomere maintenance (GO:0032204)2.51889358
179photoreceptor cell development (GO:0042461)2.50707387
180chaperone-mediated protein transport (GO:0072321)2.50577336
181parturition (GO:0007567)2.50499631
182positive regulation of icosanoid secretion (GO:0032305)2.50236686
183respiratory electron transport chain (GO:0022904)2.49837732
184rRNA catabolic process (GO:0016075)2.48392991
185resolution of meiotic recombination intermediates (GO:0000712)2.47472866
186ubiquinone metabolic process (GO:0006743)2.47292275
187regulation of cilium movement (GO:0003352)2.47029712
188multicellular organism reproduction (GO:0032504)2.46515095
189exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45579793
190synapsis (GO:0007129)2.44573939
191regulation of mitotic spindle checkpoint (GO:1903504)2.44175482
192regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.44175482
193phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43714141
194gonadal mesoderm development (GO:0007506)17.9023107
195positive regulation of male gonad development (GO:2000020)12.1112903
196sex determination (GO:0007530)11.7406119
197regulation of male gonad development (GO:2000018)10.5513704

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human8.57323367
2ZNF274_21170338_ChIP-Seq_K562_Hela4.23079695
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.86921032
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.86921032
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.86921032
6VDR_22108803_ChIP-Seq_LS180_Human3.47294105
7ZNF263_19887448_ChIP-Seq_K562_Human3.30648768
8IKZF1_21737484_ChIP-ChIP_HCT116_Human3.20152280
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10984365
10CLOCK_20551151_ChIP-Seq_293T_Human2.67517394
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66702181
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62287429
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.46163934
14GBX2_23144817_ChIP-Seq_PC3_Human2.44443831
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43062407
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.41359317
17IGF1R_20145208_ChIP-Seq_DFB_Human2.41051648
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.38999189
19ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35806747
20EZH2_22144423_ChIP-Seq_EOC_Human2.34725965
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.34038457
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.29809928
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.21965209
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.20188962
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.09454970
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07940517
27KDM2B_26808549_Chip-Seq_DND41_Human2.06824333
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.06565120
29TCF7_22412390_ChIP-Seq_EML_Mouse2.04616374
30EWS_26573619_Chip-Seq_HEK293_Human2.03002981
31CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02327029
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02267792
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.01569303
34FLI1_27457419_Chip-Seq_LIVER_Mouse2.01197631
35EST1_17652178_ChIP-ChIP_JURKAT_Human1.97350268
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.94127843
37ER_23166858_ChIP-Seq_MCF-7_Human1.92191311
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92068617
39KDM2B_26808549_Chip-Seq_K562_Human1.89783655
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.86044523
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.85588339
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84575940
43FUS_26573619_Chip-Seq_HEK293_Human1.84080193
44CREB1_26743006_Chip-Seq_LNCaP_Human1.81901203
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80448608
46FOXM1_23109430_ChIP-Seq_U2OS_Human1.79821857
47TP53_22573176_ChIP-Seq_HFKS_Human1.78843287
48MYC_18940864_ChIP-ChIP_HL60_Human1.78239279
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78075976
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76891007
51P300_19829295_ChIP-Seq_ESCs_Human1.75467617
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73963990
53TAF15_26573619_Chip-Seq_HEK293_Human1.68987350
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.67168844
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.62872327
56RUNX1_27514584_Chip-Seq_MCF-7_Human1.61722604
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.58298378
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56619714
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.55189705
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.51100051
61IRF1_19129219_ChIP-ChIP_H3396_Human1.50210984
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49563172
63TP53_22127205_ChIP-Seq_IMR90_Human1.49001291
64ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.48925595
65CHD1_26751641_Chip-Seq_LNCaP_Human1.47400086
66RACK7_27058665_Chip-Seq_MCF-7_Human1.46345912
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.45996885
68NCOR1_26117541_ChIP-Seq_K562_Human1.43246846
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.43094495
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43094495
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42902839
72JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42856512
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42816535
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.42284535
75TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41708180
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.40938620
77TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.39244348
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37949588
79AR_20517297_ChIP-Seq_VCAP_Human1.35574753
80GATA3_21878914_ChIP-Seq_MCF-7_Human1.35278108
81BCAT_22108803_ChIP-Seq_LS180_Human1.34412578
82EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.33888946
83VDR_23849224_ChIP-Seq_CD4+_Human1.33555324
84NANOG_19829295_ChIP-Seq_ESCs_Human1.32713668
85SOX2_19829295_ChIP-Seq_ESCs_Human1.32713668
86HOXB7_26014856_ChIP-Seq_BT474_Human1.31391256
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.27950802
88SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27358416
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27083955
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25976179
91RNF2_27304074_Chip-Seq_NSC_Mouse1.25917779
92CBP_20019798_ChIP-Seq_JUKART_Human1.25352332
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25352332
94NFE2_27457419_Chip-Seq_LIVER_Mouse1.25264023
95NCOR_22424771_ChIP-Seq_293T_Human1.24872401
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24584835
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.23776698
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.23595136
99OCT4_19829295_ChIP-Seq_ESCs_Human1.23479363
100AR_25329375_ChIP-Seq_VCAP_Human1.23118357
101ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22615204
102POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22240974
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.21909044
104TCF4_23295773_ChIP-Seq_U87_Human1.20563226
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20382134
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20382134
107REST_21632747_ChIP-Seq_MESCs_Mouse1.19933025
108KDM2B_26808549_Chip-Seq_JURKAT_Human1.19689251
109GATA1_22025678_ChIP-Seq_K562_Human1.19100298
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.19031797
111ELK1_19687146_ChIP-ChIP_HELA_Human1.18250206
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18080569
113POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17510158
114NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17215029
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16852515
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.16659181
117ATF3_27146783_Chip-Seq_COLON_Human1.15649318
118HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15201608
119EED_16625203_ChIP-ChIP_MESCs_Mouse1.15142304
120STAT3_23295773_ChIP-Seq_U87_Human1.14901173
121EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14843343
122MYC_19829295_ChIP-Seq_ESCs_Human1.14756940
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.14631685
124CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14252641
125TCF4_22108803_ChIP-Seq_LS180_Human1.14226299
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.13935902
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13301565
128EZH2_27294783_Chip-Seq_NPCs_Mouse1.13194874
129RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12161305
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11988752
131KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11936840
132SALL1_21062744_ChIP-ChIP_HESCs_Human1.11603642
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10912058
134SMAD4_21741376_ChIP-Seq_EPCs_Human1.10829451
135EZH2_27304074_Chip-Seq_ESCs_Mouse1.10348218
136AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10267727
137FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10075250
138CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08751685
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08578767
140ERA_21632823_ChIP-Seq_H3396_Human1.07713731
141ISL1_27105846_Chip-Seq_CPCs_Mouse1.07477702
142MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07405103
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07400269
144RUNX2_22187159_ChIP-Seq_PCA_Human1.06886359
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.06802896
146SRF_21415370_ChIP-Seq_HL-1_Mouse1.06689568
147FOXH1_21741376_ChIP-Seq_EPCs_Human1.06668920
148CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06539642
149TP63_19390658_ChIP-ChIP_HaCaT_Human1.06532680
150CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.05781420
151CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05670778
152POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04807858
153TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04510657
154LXR_22292898_ChIP-Seq_THP-1_Human1.03859392
155SMAD3_21741376_ChIP-Seq_EPCs_Human1.03002829
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02717879
157TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02625361
158CRX_20693478_ChIP-Seq_RETINA_Mouse1.02273733
159SMAD4_21799915_ChIP-Seq_A2780_Human1.00738192
160ZFX_18555785_ChIP-Seq_MESCs_Mouse1.00711411
161MYC_22102868_ChIP-Seq_BL_Human1.00710292
162P53_21459846_ChIP-Seq_SAOS-2_Human0.99725043
163SA1_27219007_Chip-Seq_ERYTHROID_Human0.99360898
164PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99159695
165PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98918789
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.98736658
167SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98509359
168CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98419152
169TAF2_19829295_ChIP-Seq_ESCs_Human0.97711810
170KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97273756
171SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97098967
172SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96945958
173TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96857219
174FOXA2_19822575_ChIP-Seq_HepG2_Human0.96395158
175UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96103965
176MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95412194
177ELK3_25401928_ChIP-Seq_HUVEC_Human0.94256134
178FLI1_21867929_ChIP-Seq_TH2_Mouse0.93490490
179EZH2_27294783_Chip-Seq_ESCs_Mouse0.93106228
180DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92077343
181CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91627839
182SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90583999
183CTCF_27219007_Chip-Seq_Bcells_Human0.87680045
184NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.86710886
185* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85997669
186EGR1_19374776_ChIP-ChIP_THP-1_Human0.85836936
187STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83665693
188EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.83018298
189TET1_21490601_ChIP-Seq_MESCs_Mouse0.82359724
190RNF2_27304074_Chip-Seq_ESCs_Mouse0.81297135
191TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79534448
192PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.78724232
193GATA3_24758297_ChIP-Seq_MCF-7_Human0.78404300
194TBX20_22080862_ChIP-Seq_HEART_Mouse0.77498856
195TBX20_22328084_ChIP-Seq_HEART_Mouse0.77498856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence8.23813650
2MP0008877_abnormal_DNA_methylation6.06281254
3MP0003878_abnormal_ear_physiology5.74694664
4MP0005377_hearing/vestibular/ear_phenot5.74694664
5MP0003195_calcinosis4.01909732
6MP0003786_premature_aging3.34594473
7MP0001661_extended_life_span2.79661143
8MP0005647_abnormal_sex_gland2.57250420
9MP0002210_abnormal_sex_determination2.53577444
10MP0003045_fibrosis2.51824545
11MP0003879_abnormal_hair_cell2.51452702
12MP0005551_abnormal_eye_electrophysiolog2.44382855
13MP0001968_abnormal_touch/_nociception2.41764668
14MP0006292_abnormal_olfactory_placode2.34634634
15MP0001727_abnormal_embryo_implantation2.28219904
16MP0001145_abnormal_male_reproductive2.26750968
17MP0003315_abnormal_perineum_morphology2.25666777
18MP0002736_abnormal_nociception_after2.20713950
19MP0005410_abnormal_fertilization2.18386382
20MP0001929_abnormal_gametogenesis2.17971849
21MP0002102_abnormal_ear_morphology2.09454599
22MP0009384_cardiac_valve_regurgitation2.05294201
23MP0008875_abnormal_xenobiotic_pharmacok2.02294358
24MP0000372_irregular_coat_pigmentation2.00618967
25MP0002876_abnormal_thyroid_physiology1.97837358
26MP0008872_abnormal_physiological_respon1.93351243
27MP0005646_abnormal_pituitary_gland1.92670815
28MP0003011_delayed_dark_adaptation1.91766070
29MP0003123_paternal_imprinting1.88238326
30MP0005645_abnormal_hypothalamus_physiol1.87550164
31MP0002254_reproductive_system_inflammat1.86865359
32MP0000653_abnormal_sex_gland1.85845257
33MP0002837_dystrophic_cardiac_calcinosis1.85587452
34MP0003698_abnormal_male_reproductive1.82677127
35MP0005623_abnormal_meninges_morphology1.79061758
36MP0004272_abnormal_basement_membrane1.77540944
37MP0009278_abnormal_bone_marrow1.77320557
38MP0004142_abnormal_muscle_tone1.76252336
39MP0001986_abnormal_taste_sensitivity1.75945444
40MP0002938_white_spotting1.74566274
41MP0004084_abnormal_cardiac_muscle1.73670561
42MP0002168_other_aberrant_phenotype1.72198137
43MP0006072_abnormal_retinal_apoptosis1.70208743
44MP0009745_abnormal_behavioral_response1.68177045
45MP0003136_yellow_coat_color1.64345197
46MP0003936_abnormal_reproductive_system1.62787736
47MP0009046_muscle_twitch1.61494377
48MP0002272_abnormal_nervous_system1.56772235
49MP0002160_abnormal_reproductive_system1.56480740
50MP0001958_emphysema1.55560573
51MP0003646_muscle_fatigue1.55030660
52MP0004133_heterotaxia1.50209009
53MP0005253_abnormal_eye_physiology1.48666180
54MP0004147_increased_porphyrin_level1.45841992
55MP0005076_abnormal_cell_differentiation1.45807432
56MP0000751_myopathy1.44015945
57MP0000537_abnormal_urethra_morphology1.33600050
58MP0001501_abnormal_sleep_pattern1.33021572
59MP0003115_abnormal_respiratory_system1.28511582
60MP0006138_congestive_heart_failure1.26196203
61MP0004742_abnormal_vestibular_system1.24123639
62MP0001486_abnormal_startle_reflex1.23135769
63MP0002572_abnormal_emotion/affect_behav1.22047365
64MP0000569_abnormal_digit_pigmentation1.20806261
65MP0002234_abnormal_pharynx_morphology1.20700927
66MP0006276_abnormal_autonomic_nervous1.20337994
67MP0001905_abnormal_dopamine_level1.19860070
68MP0001440_abnormal_grooming_behavior1.19061929
69MP0005174_abnormal_tail_pigmentation1.18827435
70MP0001984_abnormal_olfaction1.17383568
71MP0009780_abnormal_chondrocyte_physiolo1.16773254
72MP0002557_abnormal_social/conspecific_i1.15639190
73MP0000639_abnormal_adrenal_gland1.15170578
74MP0005075_abnormal_melanosome_morpholog1.13760317
75MP0003119_abnormal_digestive_system1.13231869
76MP0002638_abnormal_pupillary_reflex1.13003800
77MP0000049_abnormal_middle_ear1.12804040
78MP0000026_abnormal_inner_ear1.10791044
79MP0003880_abnormal_central_pattern1.07472446
80MP0001502_abnormal_circadian_rhythm1.07419064
81MP0005389_reproductive_system_phenotype1.07399037
82MP0005167_abnormal_blood-brain_barrier1.02452116
83MP0003866_abnormal_defecation1.02422778
84MP0004036_abnormal_muscle_relaxation1.02312090
85MP0005195_abnormal_posterior_eye1.00909073
86MP0002751_abnormal_autonomic_nervous1.00727553
87MP0002161_abnormal_fertility/fecundity0.99725637
88MP0008058_abnormal_DNA_repair0.99515121
89MP0003283_abnormal_digestive_organ0.99341296
90MP0004885_abnormal_endolymph0.99269646
91MP0003718_maternal_effect0.99125984
92MP0003121_genomic_imprinting0.98132443
93MP0002282_abnormal_trachea_morphology0.97165282
94MP0002752_abnormal_somatic_nervous0.96940205
95MP0005084_abnormal_gallbladder_morpholo0.96765990
96MP0002064_seizures0.96261213
97MP0003937_abnormal_limbs/digits/tail_de0.96153826
98MP0003942_abnormal_urinary_system0.96020868
99MP0002163_abnormal_gland_morphology0.95977162
100MP0000647_abnormal_sebaceous_gland0.94708871
101MP0010386_abnormal_urinary_bladder0.94619152
102MP0001963_abnormal_hearing_physiology0.93057128
103MP0005395_other_phenotype0.92152852
104MP0002095_abnormal_skin_pigmentation0.91775855
105MP0002735_abnormal_chemical_nociception0.91082191
106MP0003300_gastrointestinal_ulcer0.90659660
107MP0000538_abnormal_urinary_bladder0.90053962
108MP0004197_abnormal_fetal_growth/weight/0.88730385
109MP0005386_behavior/neurological_phenoty0.88648796
110MP0004924_abnormal_behavior0.88648796
111MP0000778_abnormal_nervous_system0.87769537
112MP0002928_abnormal_bile_duct0.86071125
113MP0008057_abnormal_DNA_replication0.85928022
114MP0008789_abnormal_olfactory_epithelium0.85578721
115MP0001529_abnormal_vocalization0.85252115
116MP0002733_abnormal_thermal_nociception0.84101350
117MP0002067_abnormal_sensory_capabilities0.83594367
118MP0001293_anophthalmia0.82329930
119MP0003787_abnormal_imprinting0.82198961
120MP0001970_abnormal_pain_threshold0.82052805
121MP0002277_abnormal_respiratory_mucosa0.80783256
122MP0003137_abnormal_impulse_conducting0.79102072
123MP0001730_embryonic_growth_arrest0.78871834
124MP0005248_abnormal_Harderian_gland0.78849627
125MP0004233_abnormal_muscle_weight0.76804623
126MP0001119_abnormal_female_reproductive0.76766271
127MP0005171_absent_coat_pigmentation0.76164339
128MP0002653_abnormal_ependyma_morphology0.74335339
129MP0005408_hypopigmentation0.73273111
130MP0009379_abnormal_foot_pigmentation0.70904477
131MP0008438_abnormal_cutaneous_collagen0.70524117
132MP0008961_abnormal_basal_metabolism0.69111547
133MP0003091_abnormal_cell_migration0.69035837
134MP0002295_abnormal_pulmonary_circulatio0.68992436
135MP0002084_abnormal_developmental_patter0.68404723
136MP0000428_abnormal_craniofacial_morphol0.68135815
137MP0004957_abnormal_blastocyst_morpholog0.67033393
138MP0001851_eye_inflammation0.63372254
139MP0001919_abnormal_reproductive_system0.63086888
140MP0000631_abnormal_neuroendocrine_gland0.62431695
141MP0004134_abnormal_chest_morphology0.61469038
142MP0003705_abnormal_hypodermis_morpholog0.60853133
143MP0000427_abnormal_hair_cycle0.59860651
144MP0001485_abnormal_pinna_reflex0.56559272
145MP0004145_abnormal_muscle_electrophysio0.55685338
146MP0003699_abnormal_female_reproductive0.55390672
147MP0010307_abnormal_tumor_latency0.54554735
148MP0003567_abnormal_fetal_cardiomyocyte0.53838439
149MP0002090_abnormal_vision0.53689717
150MP0004043_abnormal_pH_regulation0.53623137
151MP0002086_abnormal_extraembryonic_tissu0.53289060
152MP0000470_abnormal_stomach_morphology0.52533070
153MP0003632_abnormal_nervous_system0.51324925
154MP0003122_maternal_imprinting0.50624230
155MP0003890_abnormal_embryonic-extraembry0.48896653
156MP0005503_abnormal_tendon_morphology0.48583641
157MP0009703_decreased_birth_body0.47872824
158MP0002085_abnormal_embryonic_tissue0.47416924
159MP0002896_abnormal_bone_mineralization0.47095138
160MP0002128_abnormal_blood_circulation0.43890217
161MP0003221_abnormal_cardiomyocyte_apopto0.43280877
162MP0000383_abnormal_hair_follicle0.42402223
163MP0010678_abnormal_skin_adnexa0.41902547
164MP0001340_abnormal_eyelid_morphology0.40548217
165MP0009672_abnormal_birth_weight0.40368478
166MP0003329_amyloid_beta_deposits0.39549915
167MP0002697_abnormal_eye_size0.38269844

Predicted human phenotypes

RankGene SetZ-score
1Gonadotropin excess (HP:0000837)6.99931871
2Abnormal sex determination (HP:0012244)6.91488771
3Sex reversal (HP:0012245)6.91488771
4Male pseudohermaphroditism (HP:0000037)6.73403123
5Testicular neoplasm (HP:0010788)6.21313124
6Abnormality of male internal genitalia (HP:0000022)5.42684425
7Hand muscle atrophy (HP:0009130)5.17645627
8Azoospermia (HP:0000027)5.11133998
911 pairs of ribs (HP:0000878)4.90844502
10Metaphyseal cupping (HP:0003021)4.45038788
11Hypoplasia of the uterus (HP:0000013)4.43829858
12Facial diplegia (HP:0001349)4.35912445
13Germ cell neoplasia (HP:0100728)4.28066849
14Pancreatic cysts (HP:0001737)4.26610511
15Ankle clonus (HP:0011448)4.22337805
16Tongue fasciculations (HP:0001308)4.16415932
17Distal upper limb amyotrophy (HP:0007149)4.11191004
18Upper limb amyotrophy (HP:0009129)4.11191004
19Abnormality of midbrain morphology (HP:0002418)3.99062673
20Molar tooth sign on MRI (HP:0002419)3.99062673
21Mesangial abnormality (HP:0001966)3.96900248
22Abnormal spermatogenesis (HP:0008669)3.93252771
23Pancreatic fibrosis (HP:0100732)3.93075245
24Muscle fibrillation (HP:0010546)3.78915405
25Stridor (HP:0010307)3.77349821
26True hermaphroditism (HP:0010459)3.73482022
27Infertility (HP:0000789)3.72233498
28Secondary amenorrhea (HP:0000869)3.67799278
29Type II lissencephaly (HP:0007260)3.66494217
30Congenital stationary night blindness (HP:0007642)3.64082314
31Diaphragmatic weakness (HP:0009113)3.63087392
32Missing ribs (HP:0000921)3.49518145
33Nephronophthisis (HP:0000090)3.43484941
34Rectal prolapse (HP:0002035)3.41932145
35Abnormality of the lower motor neuron (HP:0002366)3.41605395
36Ankle contracture (HP:0006466)3.30542258
37Hypoplastic ischia (HP:0003175)3.27286393
38Flat capital femoral epiphysis (HP:0003370)3.18787720
39Abnormality of the renal cortex (HP:0011035)3.15557060
40Hypoventilation (HP:0002791)3.03128601
41Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.02271291
42Concave nail (HP:0001598)3.00845303
43Aplasia/hypoplasia of the uterus (HP:0008684)2.98470108
44Abnormality of the renal medulla (HP:0100957)2.98231198
45Hypoplastic left heart (HP:0004383)2.98112077
46Abnormality of the vocal cords (HP:0008777)2.89542466
47Tubular atrophy (HP:0000092)2.86042556
48Pendular nystagmus (HP:0012043)2.82604559
49Abnormality of the musculature of the hand (HP:0001421)2.80820846
50Myopathic facies (HP:0002058)2.79731916
51Clumsiness (HP:0002312)2.78306597
52Abnormal drinking behavior (HP:0030082)2.77572427
53Polydipsia (HP:0001959)2.77572427
54Cystic liver disease (HP:0006706)2.68997305
55Keratoconus (HP:0000563)2.67821118
56Increased corneal curvature (HP:0100692)2.67821118
57Medial flaring of the eyebrow (HP:0010747)2.65045240
58Bladder diverticulum (HP:0000015)2.64767997
59Abnormality of the ischium (HP:0003174)2.62211464
60Occipital encephalocele (HP:0002085)2.61505198
61Pulmonary fibrosis (HP:0002206)2.59329708
62Disproportionate short-trunk short stature (HP:0003521)2.55092850
63Polycystic ovaries (HP:0000147)2.53396512
64Primary amenorrhea (HP:0000786)2.51192771
65Abnormality of the proximal phalanges of the hand (HP:0009834)2.50941373
66Acute necrotizing encephalopathy (HP:0006965)2.50692343
67Nausea (HP:0002018)2.50222626
68Clonus (HP:0002169)2.49877419
69Cerebellar dysplasia (HP:0007033)2.48172863
70Mitochondrial inheritance (HP:0001427)2.42177693
71Abnormality of the phalanges of the 2nd finger (HP:0009541)2.38453783
72Chronic hepatic failure (HP:0100626)2.37319246
73Increased CSF lactate (HP:0002490)2.36163127
74Renovascular hypertension (HP:0100817)2.35164566
75Sclerocornea (HP:0000647)2.34946492
76Abolished electroretinogram (ERG) (HP:0000550)2.33132256
77Premature ovarian failure (HP:0008209)2.32480754
78Lipid accumulation in hepatocytes (HP:0006561)2.29593229
79Abnormal rod and cone electroretinograms (HP:0008323)2.26774502
80Abnormality of the labia minora (HP:0012880)2.25896432
81Congenital, generalized hypertrichosis (HP:0004540)2.24452414
82Severe muscular hypotonia (HP:0006829)2.24121964
83Attenuation of retinal blood vessels (HP:0007843)2.23801664
84Progressive macrocephaly (HP:0004481)2.22677366
85Renal cortical cysts (HP:0000803)2.16198545
86Polyuria (HP:0000103)2.15933459
87Hypoplastic heart (HP:0001961)2.12863995
88Lissencephaly (HP:0001339)2.12816180
89Hyperacusis (HP:0010780)2.11883635
90Acute encephalopathy (HP:0006846)2.11246784
91Abnormality of the calcaneus (HP:0008364)2.11171689
92Abnormal connection of the cardiac segments (HP:0011545)2.10745753
93Abnormal ventriculo-arterial connection (HP:0011563)2.10745753
94Transposition of the great arteries (HP:0001669)2.10745753
95Lymphangioma (HP:0100764)2.09727399
96Abnormality of the pubic bones (HP:0003172)2.08448929
97Increased hepatocellular lipid droplets (HP:0006565)2.08038083
98Abnormality of alanine metabolism (HP:0010916)2.07916531
99Hyperalaninemia (HP:0003348)2.07916531
100Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07916531
101Ovarian neoplasm (HP:0100615)2.06373648
102Fasciculations (HP:0002380)2.06142406
103Abnormal mitochondria in muscle tissue (HP:0008316)2.05866396
104Abnormality of the femoral head (HP:0003368)2.04612100
105Hypothermia (HP:0002045)2.03891430
106Protrusio acetabuli (HP:0003179)2.03629729
107Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03457333
108Cerebral aneurysm (HP:0004944)2.02317743
109Absent epiphyses (HP:0010577)2.02001477
110Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02001477
111Absent thumb (HP:0009777)2.01117353
112Aplasia/Hypoplasia of the tongue (HP:0010295)2.00149207
113Gonadal dysgenesis (HP:0000133)10.7078960
114Male infertility (HP:0003251)10.0722163
115Hyperventilation (HP:0002883)1.99636631
116Anencephaly (HP:0002323)1.99129422
117Abnormality of the pons (HP:0007361)1.99055762
118Irregular epiphyses (HP:0010582)1.97286704
119Congenital hepatic fibrosis (HP:0002612)1.95917043
120Insomnia (HP:0100785)1.95624115
121Decreased central vision (HP:0007663)1.95379555
122Aplasia/Hypoplasia of the patella (HP:0006498)1.95321701
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.95099979
124Hypoplasia of the pons (HP:0012110)1.93691626
125Furrowed tongue (HP:0000221)1.92961170
126Abnormal number of erythroid precursors (HP:0012131)1.92866744
127Abnormality of the epiphysis of the femoral head (HP:0010574)1.92628209
128Stage 5 chronic kidney disease (HP:0003774)1.92229559
129Patellar aplasia (HP:0006443)1.91901168
130Large for gestational age (HP:0001520)1.91894978
131Inability to walk (HP:0002540)1.91810549
132Methylmalonic acidemia (HP:0002912)1.91654046
133Selective tooth agenesis (HP:0001592)1.91259545
134Arthropathy (HP:0003040)1.89108242
135Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.88910086
136Retinal dysplasia (HP:0007973)1.88354535
137Aplasia/Hypoplasia of the spleen (HP:0010451)1.87932570
138Gait imbalance (HP:0002141)1.87850816
139Renal duplication (HP:0000075)1.87387248
1403-Methylglutaconic aciduria (HP:0003535)1.86305989
141Gaze-evoked nystagmus (HP:0000640)1.85643895
142Hepatocellular necrosis (HP:0001404)1.84582604
143Hepatic necrosis (HP:0002605)1.83490552
144Arachnodactyly (HP:0001166)1.83396126
145Irregular vertebral endplates (HP:0003301)1.83366516
146Aplasia/Hypoplasia of the uvula (HP:0010293)1.83184331
147Optic disc pallor (HP:0000543)1.82662187
148Hypoplastic pelvis (HP:0008839)1.82390740
149Congenital primary aphakia (HP:0007707)1.82251506
150Dynein arm defect of respiratory motile cilia (HP:0012255)1.82217645
151Absent/shortened dynein arms (HP:0200106)1.82217645
152Barrel-shaped chest (HP:0001552)1.80765290
153Overriding aorta (HP:0002623)1.80068946
154Abnormality of the vertebral endplates (HP:0005106)1.79865435
155Bulbous nose (HP:0000414)1.79589401
156Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78419763
157Optic nerve hypoplasia (HP:0000609)1.77871138
158Aplasia/Hypoplasia of the tibia (HP:0005772)1.77587365
159Thin ribs (HP:0000883)1.77025324
160Increased variability in muscle fiber diameter (HP:0003557)1.76755017
161Pachygyria (HP:0001302)1.76011006
162Oligodactyly (HP:0012165)1.75288023
163Nephrogenic diabetes insipidus (HP:0009806)1.75205312
164Limb-girdle muscle weakness (HP:0003325)1.71577492
165Female pseudohermaphroditism (HP:0010458)1.70762530
166Elfin facies (HP:0004428)1.66237511
167Inguinal hernia (HP:0000023)1.64972205
168Subacute progressive viral hepatitis (HP:0006572)1.64112674
169Fibular hypoplasia (HP:0003038)1.64001096
170Hyperpituitarism (HP:0010514)1.61667032
171Hypoplasia of the iris (HP:0007676)1.61325105
172Hypoplastic iliac wings (HP:0002866)1.59705075
173Pulmonary artery stenosis (HP:0004415)1.58158169
174Rhizomelia (HP:0008905)1.55006103
175Vitreoretinal degeneration (HP:0000655)1.53796216
176Hyporeflexia of lower limbs (HP:0002600)1.52751905
177Abnormality of the peritoneum (HP:0002585)1.51907965
178Primary adrenal insufficiency (HP:0008207)1.49542258
179Childhood onset (HP:0011463)1.49208502
180Synostosis involving the elbow (HP:0003938)1.48681581
181Humeroradial synostosis (HP:0003041)1.48681581
182Back pain (HP:0003418)1.47774657
183Abnormality of skeletal muscle fiber size (HP:0012084)1.45706798
184Amyotrophic lateral sclerosis (HP:0007354)1.45331063
185Pointed chin (HP:0000307)1.45183185
186Flat cornea (HP:0007720)1.44539414
187Anomalous pulmonary venous return (HP:0010772)1.44220840
188Neoplasm of the heart (HP:0100544)1.43653824
189Abnormality of the pulmonary veins (HP:0011718)1.42843953
190Proximal placement of thumb (HP:0009623)1.41433533
191Aortic aneurysm (HP:0004942)1.40507188
192Bronchomalacia (HP:0002780)1.39717232
193Bulbar palsy (HP:0001283)1.39665912
194Exercise-induced myalgia (HP:0003738)1.38430318
195Postural tremor (HP:0002174)1.38391943
196Ependymoma (HP:0002888)1.38207017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYRO35.81901246
2CDK125.60547212
3FRK5.03248064
4ADRBK23.58342636
5WNK33.52173737
6ICK3.21323835
7TRIB33.17006452
8ZAK3.01114863
9BMPR1B3.00005945
10TLK12.96920397
11PRKD32.94854454
12RIPK12.91992790
13PINK12.83402408
14NUAK12.76698303
15BRD42.76426766
16GRK12.62926873
17MAP4K22.35506140
18MAP3K42.30941878
19PTK62.22558445
20CDK72.19983739
21LATS12.15830579
22TAOK32.11932712
23CDK91.95108200
24WNK11.87894390
25PKN21.78448283
26WNK41.75582537
27VRK21.74896162
28DAPK21.74720767
29TRIM281.69382719
30MAP3K101.67821921
31EPHB11.65636177
32MUSK1.62515391
33TXK1.57286251
34PDGFRA1.54416191
35INSRR1.51309304
36PAK41.46904256
37CDK41.46762900
38OXSR11.43552686
39MAPK131.42615756
40DYRK21.42582067
41MYLK1.41124620
42EEF2K1.35442807
43PTK2B1.33830725
44CASK1.31749337
45CDC71.28646656
46BRSK21.25070012
47CSNK1A1L1.21703492
48MTOR1.21543780
49NEK21.12965429
50ADRBK11.11097993
51LMTK21.10231653
52LATS21.09614387
53VRK11.07887304
54PAK21.05758671
55STK31.01981280
56WEE10.99996166
57MAP2K60.99592281
58MAP2K20.99148220
59PRKCG0.98956769
60BCKDK0.98322136
61FGFR20.97873452
62TNK20.97428986
63NME10.94017905
64BMX0.93515222
65PHKG10.93123282
66PHKG20.93123282
67TNIK0.92608390
68PIK3CA0.92299364
69PRKCE0.92153222
70MAPKAPK30.89092763
71PDK30.89078136
72PDK40.89078136
73PTK20.88177184
74MST40.82510380
75TIE10.81911744
76PLK20.80313187
77CAMK1G0.78701468
78CAMK1D0.78420945
79PRKCI0.77248770
80PLK30.76378273
81STK160.76045318
82TAF10.75964289
83CDC42BPA0.74743716
84IKBKB0.73903828
85FGFR10.73783064
86DMPK0.71285640
87BCR0.70654965
88PNCK0.70608252
89IRAK10.70474732
90DAPK10.70137159
91TESK10.68232923
92ERBB20.65586265
93RET0.65201825
94FER0.65058671
95ERN10.64720266
96TGFBR10.63122209
97RPS6KA50.62647452
98MAP2K70.62611746
99MET0.61140521
100CSNK1G30.60713103
101CHEK10.60327993
102PKN10.58212054
103SCYL20.57937498
104STK38L0.57765120
105CSNK1A10.57690598
106FLT30.57258010
107KSR20.57023604
108MARK10.56429338
109PASK0.55700801
110MAP2K40.55046586
111PAK60.53948732
112CAMK2A0.53657790
113MINK10.52530564
114ATM0.51423065
115DDR20.51106751
116KIT0.51065464
117CSNK1G20.50461707
118PDGFRB0.50314703
119ATR0.48919372
120CSNK1G10.48637515
121PRKD20.48212415
122PAK30.46720895
123PRKACA0.46678409
124GRK50.46129575
125EGFR0.46060430
126NTRK30.46040910
127NTRK20.45180867
128MAPK10.44955876
129MAPKAPK50.44917748
130EPHA40.44704060
131PRKACB0.43933920
132PLK10.43865232
133LIMK10.43807399
134CDK20.43090315
135EIF2AK30.42506797
136MAP3K20.42144426
137PRKCZ0.42047709
138CAMK10.41707796
139CHUK0.41592075
140TTN0.40676657
141CDK10.40659591
142MKNK20.40173597
143PRKCQ0.39900961
144STK110.39718486
145GSK3B0.39564932
146SIK20.39090124
147GSK3A0.38498891
148MAPK30.38361377
149PRKDC0.37436801
150CAMK2D0.36887557
151STK40.36291938
152MKNK10.35708919
153CDK60.35549252
154CSNK1D0.35194070
155PRKCA0.34863626
156EPHA30.34539307
157EIF2AK20.34141520
158TEC0.32891021
159CAMKK20.32828253
160CHEK20.32503799
161MAPK140.32484462
162DAPK30.32279463
163ERBB30.32224383
164ROCK10.31104862
165ACVR1B0.30544584
166STK390.29706094
167ALK0.29041208
168CSNK1E0.27894480
169NTRK10.27223826
170TTK0.26546102
171CSK0.25927776
172MAPK150.25916811
173RPS6KA20.25530532

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.35646405
2Oxidative phosphorylation_Homo sapiens_hsa001902.93206762
3Dorso-ventral axis formation_Homo sapiens_hsa043202.86931310
4Phototransduction_Homo sapiens_hsa047442.84188788
5ECM-receptor interaction_Homo sapiens_hsa045122.65105149
6Vitamin digestion and absorption_Homo sapiens_hsa049772.61882488
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60919953
8Linoleic acid metabolism_Homo sapiens_hsa005912.58740552
9Fatty acid metabolism_Homo sapiens_hsa012122.54572540
10Hedgehog signaling pathway_Homo sapiens_hsa043402.53588098
11TGF-beta signaling pathway_Homo sapiens_hsa043502.49413896
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49324648
13Lysine degradation_Homo sapiens_hsa003102.47303809
14Nitrogen metabolism_Homo sapiens_hsa009102.43494882
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.30438051
16Protein export_Homo sapiens_hsa030602.27885761
17Small cell lung cancer_Homo sapiens_hsa052222.24605882
18Amoebiasis_Homo sapiens_hsa051462.22650840
19Homologous recombination_Homo sapiens_hsa034402.21813258
20mRNA surveillance pathway_Homo sapiens_hsa030152.18719082
21Parkinsons disease_Homo sapiens_hsa050122.14788759
22RNA polymerase_Homo sapiens_hsa030202.10635995
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97152100
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.94382564
25Fanconi anemia pathway_Homo sapiens_hsa034601.87962731
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.83025267
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82662206
28Butanoate metabolism_Homo sapiens_hsa006501.82341317
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81053252
30Ether lipid metabolism_Homo sapiens_hsa005651.78538178
31Ovarian steroidogenesis_Homo sapiens_hsa049131.77245350
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71507247
33Axon guidance_Homo sapiens_hsa043601.70551120
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70408546
35Caffeine metabolism_Homo sapiens_hsa002321.70272179
36Focal adhesion_Homo sapiens_hsa045101.68026683
37Fatty acid elongation_Homo sapiens_hsa000621.67487008
38Notch signaling pathway_Homo sapiens_hsa043301.67328934
39Tryptophan metabolism_Homo sapiens_hsa003801.65031391
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.64492051
41Protein digestion and absorption_Homo sapiens_hsa049741.64074417
42Renin secretion_Homo sapiens_hsa049241.61070555
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.56237561
44One carbon pool by folate_Homo sapiens_hsa006701.52717516
45Nicotine addiction_Homo sapiens_hsa050331.49427513
46Sulfur relay system_Homo sapiens_hsa041221.47659721
47Huntingtons disease_Homo sapiens_hsa050161.44056134
48Hippo signaling pathway_Homo sapiens_hsa043901.43381678
49Proteasome_Homo sapiens_hsa030501.42459455
50Pyruvate metabolism_Homo sapiens_hsa006201.40621918
51Basal cell carcinoma_Homo sapiens_hsa052171.38886157
52Alzheimers disease_Homo sapiens_hsa050101.38846807
53Tight junction_Homo sapiens_hsa045301.37514271
54Mineral absorption_Homo sapiens_hsa049781.36939406
55RNA transport_Homo sapiens_hsa030131.36534466
56Ribosome_Homo sapiens_hsa030101.33434454
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32172102
58Complement and coagulation cascades_Homo sapiens_hsa046101.31359370
59Sulfur metabolism_Homo sapiens_hsa009201.30656669
60Cardiac muscle contraction_Homo sapiens_hsa042601.29746784
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.28536515
62cAMP signaling pathway_Homo sapiens_hsa040241.27930552
63RNA degradation_Homo sapiens_hsa030181.26028958
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.25897732
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24863518
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24494939
67Oocyte meiosis_Homo sapiens_hsa041141.21490768
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21215845
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.19654936
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16656687
71Toxoplasmosis_Homo sapiens_hsa051451.16124266
72PPAR signaling pathway_Homo sapiens_hsa033201.16067432
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14301365
74Fatty acid degradation_Homo sapiens_hsa000711.11045045
75Olfactory transduction_Homo sapiens_hsa047401.08605575
76Aldosterone synthesis and secretion_Homo sapiens_hsa049251.07483497
77Asthma_Homo sapiens_hsa053101.06907693
78Arachidonic acid metabolism_Homo sapiens_hsa005901.04311756
79Taste transduction_Homo sapiens_hsa047421.03402477
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01140971
81Central carbon metabolism in cancer_Homo sapiens_hsa052301.01032170
82Viral myocarditis_Homo sapiens_hsa054161.00095853
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97433574
84Adherens junction_Homo sapiens_hsa045200.97061818
85Estrogen signaling pathway_Homo sapiens_hsa049150.96869716
86Chemical carcinogenesis_Homo sapiens_hsa052040.96716060
87Peroxisome_Homo sapiens_hsa041460.96504924
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.95609705
89Collecting duct acid secretion_Homo sapiens_hsa049660.94710395
90Propanoate metabolism_Homo sapiens_hsa006400.92207451
91Regulation of autophagy_Homo sapiens_hsa041400.91279351
92Morphine addiction_Homo sapiens_hsa050320.90295940
93Insulin resistance_Homo sapiens_hsa049310.90235920
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.90054549
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89611215
96Non-homologous end-joining_Homo sapiens_hsa034500.87822305
97Antigen processing and presentation_Homo sapiens_hsa046120.87099136
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84146158
99Basal transcription factors_Homo sapiens_hsa030220.80166337
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79916815
101Pathways in cancer_Homo sapiens_hsa052000.79872348
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79511683
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79424662
104Insulin secretion_Homo sapiens_hsa049110.78069594
105mTOR signaling pathway_Homo sapiens_hsa041500.77773879
106VEGF signaling pathway_Homo sapiens_hsa043700.77085574
107Proteoglycans in cancer_Homo sapiens_hsa052050.76918965
108Selenocompound metabolism_Homo sapiens_hsa004500.76883295
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75548156
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73789635
111Wnt signaling pathway_Homo sapiens_hsa043100.73727642
112Pyrimidine metabolism_Homo sapiens_hsa002400.72592772
113Purine metabolism_Homo sapiens_hsa002300.72551024
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72174144
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.71154176
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70265574
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70188879
118Endometrial cancer_Homo sapiens_hsa052130.69894989
119Cell cycle_Homo sapiens_hsa041100.69611932
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.69568291
121Fat digestion and absorption_Homo sapiens_hsa049750.69378794
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68861227
123Spliceosome_Homo sapiens_hsa030400.68576586
124Gastric acid secretion_Homo sapiens_hsa049710.67783309
125Metabolic pathways_Homo sapiens_hsa011000.67156215
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66371932
127Herpes simplex infection_Homo sapiens_hsa051680.65790508
128Type I diabetes mellitus_Homo sapiens_hsa049400.63348513
129beta-Alanine metabolism_Homo sapiens_hsa004100.63219851
130Primary bile acid biosynthesis_Homo sapiens_hsa001200.61796629
131Colorectal cancer_Homo sapiens_hsa052100.61333327
132Bile secretion_Homo sapiens_hsa049760.60325997
133ABC transporters_Homo sapiens_hsa020100.59786685
134HTLV-I infection_Homo sapiens_hsa051660.59018385
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.58786491
136Steroid hormone biosynthesis_Homo sapiens_hsa001400.56021964
137Serotonergic synapse_Homo sapiens_hsa047260.55735488
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.55689821
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.54571877
140Circadian entrainment_Homo sapiens_hsa047130.54212550
141Inositol phosphate metabolism_Homo sapiens_hsa005620.53904868
142Oxytocin signaling pathway_Homo sapiens_hsa049210.52437204
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51782359
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.50650567
145Nucleotide excision repair_Homo sapiens_hsa034200.49769106
146Steroid biosynthesis_Homo sapiens_hsa001000.48961581
147Glutamatergic synapse_Homo sapiens_hsa047240.48597767
148Allograft rejection_Homo sapiens_hsa053300.48410822
149Prostate cancer_Homo sapiens_hsa052150.48186491
150GABAergic synapse_Homo sapiens_hsa047270.47593162
151N-Glycan biosynthesis_Homo sapiens_hsa005100.46794074
152Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46405996
153Salivary secretion_Homo sapiens_hsa049700.45629583
154Glioma_Homo sapiens_hsa052140.45595357
155Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44916487
156Histidine metabolism_Homo sapiens_hsa003400.44636730
157AMPK signaling pathway_Homo sapiens_hsa041520.44343031
158Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44068436
159Glycerolipid metabolism_Homo sapiens_hsa005610.43677864
160Autoimmune thyroid disease_Homo sapiens_hsa053200.43168129
161Base excision repair_Homo sapiens_hsa034100.42651490
162Glucagon signaling pathway_Homo sapiens_hsa049220.42380569
163Thyroid hormone synthesis_Homo sapiens_hsa049180.42124191
164Leukocyte transendothelial migration_Homo sapiens_hsa046700.40831978
165Viral carcinogenesis_Homo sapiens_hsa052030.40399785
166Vitamin B6 metabolism_Homo sapiens_hsa007500.40216603
167Influenza A_Homo sapiens_hsa051640.40202099
168Prolactin signaling pathway_Homo sapiens_hsa049170.39485401
169Insulin signaling pathway_Homo sapiens_hsa049100.39428302
170MicroRNAs in cancer_Homo sapiens_hsa052060.38647093
171ErbB signaling pathway_Homo sapiens_hsa040120.38245591
172Chronic myeloid leukemia_Homo sapiens_hsa052200.37485040
173Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37417529
174Graft-versus-host disease_Homo sapiens_hsa053320.37144616
175Retinol metabolism_Homo sapiens_hsa008300.36083269
176Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35305110
177Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35173479
178Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34564033
179Choline metabolism in cancer_Homo sapiens_hsa052310.34310713
180Folate biosynthesis_Homo sapiens_hsa007900.33896991
181Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.33354302
182Rheumatoid arthritis_Homo sapiens_hsa053230.32006386
183Glutathione metabolism_Homo sapiens_hsa004800.29511734

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