AARS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1folic acid-containing compound biosynthetic process (GO:0009396)6.19652716
2regulation of translational termination (GO:0006449)4.81313879
3nuclear pore organization (GO:0006999)4.81269533
4tetrahydrofolate metabolic process (GO:0046653)4.67339462
5nuclear pore complex assembly (GO:0051292)4.54173364
6regulation of posttranscriptional gene silencing (GO:0060147)4.32335650
7regulation of gene silencing by miRNA (GO:0060964)4.32335650
8regulation of gene silencing by RNA (GO:0060966)4.32335650
9mitotic chromosome condensation (GO:0007076)4.27879923
10glycine metabolic process (GO:0006544)4.27274990
11* regulation of translational fidelity (GO:0006450)4.25535722
12L-serine metabolic process (GO:0006563)4.23862650
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.20967920
14DNA unwinding involved in DNA replication (GO:0006268)4.13571924
15heterochromatin organization (GO:0070828)4.05634606
16retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.05486562
17serine family amino acid biosynthetic process (GO:0009070)4.01890081
18protein localization to kinetochore (GO:0034501)4.00298838
19pre-miRNA processing (GO:0031054)3.94080900
20one-carbon metabolic process (GO:0006730)3.91492837
21chaperone-mediated protein complex assembly (GO:0051131)3.84551450
22mitotic nuclear envelope disassembly (GO:0007077)3.81570782
23protein retention in ER lumen (GO:0006621)3.78656924
24IMP biosynthetic process (GO:0006188)3.71879845
25DNA replication-dependent nucleosome assembly (GO:0006335)3.70983633
26DNA replication-dependent nucleosome organization (GO:0034723)3.70983633
27nuclear envelope disassembly (GO:0051081)3.69185111
28membrane disassembly (GO:0030397)3.69185111
29protein complex localization (GO:0031503)3.69098253
30folic acid-containing compound metabolic process (GO:0006760)3.66458104
31regulation of RNA export from nucleus (GO:0046831)3.60101638
32peptidyl-arginine omega-N-methylation (GO:0035247)3.54964360
33L-alpha-amino acid transmembrane transport (GO:1902475)3.49835860
34folic acid metabolic process (GO:0046655)3.44854750
35regulation of nucleobase-containing compound transport (GO:0032239)3.41712243
36regulation of hippo signaling (GO:0035330)3.39336773
37protein export from nucleus (GO:0006611)3.38284205
38proline metabolic process (GO:0006560)3.36174999
39cellular protein complex localization (GO:0034629)3.35103653
40serine family amino acid metabolic process (GO:0009069)3.35103053
41nucleobase biosynthetic process (GO:0046112)3.31417392
42cytoskeletal anchoring at plasma membrane (GO:0007016)3.29342457
43pteridine-containing compound biosynthetic process (GO:0042559)3.29242377
44glucose 6-phosphate metabolic process (GO:0051156)3.26979549
45paraxial mesoderm development (GO:0048339)3.25905333
46COPI coating of Golgi vesicle (GO:0048205)3.25164632
47Golgi transport vesicle coating (GO:0048200)3.25164632
48spliceosomal tri-snRNP complex assembly (GO:0000244)3.24668021
49negative regulation of fibrinolysis (GO:0051918)3.21841092
50pore complex assembly (GO:0046931)3.19314013
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19169475
52DNA strand elongation involved in DNA replication (GO:0006271)3.16915928
53negative regulation of fatty acid biosynthetic process (GO:0045717)3.16815996
54IMP metabolic process (GO:0046040)3.13807365
55vesicle coating (GO:0006901)3.12072230
56positive regulation of SMAD protein import into nucleus (GO:0060391)3.11691322
57DNA strand elongation (GO:0022616)3.10987864
58regulation of mitotic spindle organization (GO:0060236)3.07501727
59sister chromatid segregation (GO:0000819)3.06699394
60peptidyl-arginine N-methylation (GO:0035246)3.06387423
61peptidyl-arginine methylation (GO:0018216)3.06387423
62activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.05572415
63mitotic sister chromatid segregation (GO:0000070)3.04303037
64positive regulation of nuclease activity (GO:0032075)3.02900085
65DNA duplex unwinding (GO:0032508)3.02695198
66histone arginine methylation (GO:0034969)3.01419497
67anterior/posterior axis specification, embryo (GO:0008595)3.01389964
68ribosome assembly (GO:0042255)3.01335415
69DNA geometric change (GO:0032392)3.00828925
70chromatin assembly (GO:0031497)2.98437630
71DNA topological change (GO:0006265)2.97658244
72protein localization to chromosome, centromeric region (GO:0071459)2.96336438
73mitochondrial DNA metabolic process (GO:0032042)2.96055299
74nuclear envelope organization (GO:0006998)2.94963802
75regulation of cholesterol homeostasis (GO:2000188)2.93787189
76regulation of spindle organization (GO:0090224)2.93709030
77negative regulation of histone methylation (GO:0031061)2.90028459
78regulation of histone H3-K27 methylation (GO:0061085)2.89515295
79dicarboxylic acid biosynthetic process (GO:0043650)2.86737821
80lysine catabolic process (GO:0006554)2.86184378
81lysine metabolic process (GO:0006553)2.86184378
82sodium ion export (GO:0071436)2.85560606
83regulation of mammary gland epithelial cell proliferation (GO:0033599)2.85247879
84mitotic sister chromatid cohesion (GO:0007064)2.84779986
85* ER-nucleus signaling pathway (GO:0006984)2.84682888
86protein-DNA complex disassembly (GO:0032986)2.84603220
87nucleosome disassembly (GO:0006337)2.84603220
88maternal placenta development (GO:0001893)2.83570933
89histone H2A monoubiquitination (GO:0035518)2.83340474
90* tRNA aminoacylation for protein translation (GO:0006418)2.82804756
91pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.82270285
92UMP metabolic process (GO:0046049)2.82270285
93pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.82270285
94UMP biosynthetic process (GO:0006222)2.82270285
95intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.82169750
96establishment of integrated proviral latency (GO:0075713)2.82051161
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.81626673
984-hydroxyproline metabolic process (GO:0019471)2.81272190
99mitotic G1 DNA damage checkpoint (GO:0031571)2.80255133
100activation of Rac GTPase activity (GO:0032863)2.79081232
101regulation of nuclease activity (GO:0032069)2.79027478
102establishment of apical/basal cell polarity (GO:0035089)2.78749314
103glutamine metabolic process (GO:0006541)2.78538815
104regulation of early endosome to late endosome transport (GO:2000641)2.78218530
105formation of translation preinitiation complex (GO:0001731)2.78188666
106alpha-linolenic acid metabolic process (GO:0036109)2.76511356
107serine family amino acid catabolic process (GO:0009071)2.76021878
108focal adhesion assembly (GO:0048041)2.76004997
109cell-substrate adherens junction assembly (GO:0007045)2.76004997
110protoporphyrinogen IX metabolic process (GO:0046501)2.74828745
111glycolytic process (GO:0006096)2.74687844
112pentose-phosphate shunt (GO:0006098)2.73971675
113chromosome condensation (GO:0030261)2.73731175
114NLS-bearing protein import into nucleus (GO:0006607)2.73375766
115L-phenylalanine metabolic process (GO:0006558)2.71427336
116erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.71427336
117spindle assembly involved in mitosis (GO:0090307)2.71411831
118positive regulation of chromosome segregation (GO:0051984)2.71371555
119polarized epithelial cell differentiation (GO:0030859)2.71122407
120regulation of SMAD protein import into nucleus (GO:0060390)2.70994935
121negative regulation of cell size (GO:0045792)2.70510656
122pteridine-containing compound metabolic process (GO:0042558)2.70186507
123* cellular response to unfolded protein (GO:0034620)2.69957903
124cysteine metabolic process (GO:0006534)2.69464691
125purine nucleobase biosynthetic process (GO:0009113)2.68636432
126dosage compensation (GO:0007549)2.67823105
127homocysteine metabolic process (GO:0050667)2.67348978
128glucocorticoid receptor signaling pathway (GO:0042921)2.67279351
129* tRNA aminoacylation (GO:0043039)2.65418721
130* amino acid activation (GO:0043038)2.65418721
131negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65362802
132biotin metabolic process (GO:0006768)2.65199874
133glutamine family amino acid biosynthetic process (GO:0009084)2.64570785
134DNA replication initiation (GO:0006270)2.64233853
135NADPH regeneration (GO:0006740)2.63750096
136peptidyl-lysine dimethylation (GO:0018027)2.62055987
137nucleobase-containing small molecule interconversion (GO:0015949)2.60289523
138ER overload response (GO:0006983)2.60219366
139NADH metabolic process (GO:0006734)2.59123115
140alpha-amino acid biosynthetic process (GO:1901607)2.57707706
141mitotic G1/S transition checkpoint (GO:0044819)2.57039560
142proline biosynthetic process (GO:0006561)2.56647337
143protein maturation by protein folding (GO:0022417)2.55756386
144COPII vesicle coating (GO:0048208)2.55669447
145regulation of histone H3-K9 methylation (GO:0051570)2.55550620
146* endoplasmic reticulum unfolded protein response (GO:0030968)2.55503697
147determination of adult lifespan (GO:0008340)2.55360334
148adherens junction assembly (GO:0034333)2.53959126
149* cellular response to topologically incorrect protein (GO:0035967)2.50911053
150oxaloacetate metabolic process (GO:0006107)2.47453694
151gluconeogenesis (GO:0006094)2.45770235
152stress granule assembly (GO:0034063)2.45092380
153glucose catabolic process (GO:0006007)2.43485088
154telomere maintenance via semi-conservative replication (GO:0032201)2.43003635
155DNA conformation change (GO:0071103)2.41306216
156monosaccharide biosynthetic process (GO:0046364)2.40014076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.53661266
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.20370863
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.21532846
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.11436341
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09381038
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.84572710
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.78593967
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51285801
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50933143
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.49533663
11ESR1_15608294_ChIP-ChIP_MCF-7_Human2.44863774
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.39528833
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.28732657
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.27982120
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.25234959
16MYC_22102868_ChIP-Seq_BL_Human2.10491079
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02215404
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01694637
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01490640
20ZNF263_19887448_ChIP-Seq_K562_Human1.99929508
21* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.99426687
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98129511
23* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.96389184
24AR_21909140_ChIP-Seq_LNCAP_Human1.92466429
25RXR_22158963_ChIP-Seq_LIVER_Mouse1.91940398
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.90581253
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90530192
28CLOCK_20551151_ChIP-Seq_293T_Human1.86086108
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.72938874
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70790306
31* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69537230
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.68045940
33XRN2_22483619_ChIP-Seq_HELA_Human1.66975101
34* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63607044
35* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61009247
36* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.60577195
37TCF3_18692474_ChIP-Seq_MEFs_Mouse1.59599152
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57432965
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.56896770
40SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54757422
41* ATF3_27146783_Chip-Seq_COLON_Human1.54472163
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.53869734
43PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.53452917
44NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52824416
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52418800
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52418800
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52418800
48LXR_22292898_ChIP-Seq_THP-1_Human1.51610200
49E2F1_21310950_ChIP-Seq_MCF-7_Human1.51081999
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50766013
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50294930
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48255602
53NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46357478
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46279427
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46111723
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.42840220
57TFEB_21752829_ChIP-Seq_HELA_Human1.42416642
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35366873
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34232029
60* LXR_22158963_ChIP-Seq_LIVER_Mouse1.33182609
61WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31793784
62* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31648893
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.31447492
64SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.31188092
65KDM5A_27292631_Chip-Seq_BREAST_Human1.30567107
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.30287535
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29263895
68CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26376962
69HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25917017
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25702665
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.25555806
72KDM2B_26808549_Chip-Seq_K562_Human1.23934929
73TCF3_18692474_ChIP-Seq_MESCs_Mouse1.22049105
74SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22032964
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21819572
76* NCOR1_26117541_ChIP-Seq_K562_Human1.21687207
77* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19990716
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19661144
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18763306
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.18161317
81HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.17564782
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.16305835
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16206241
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15670909
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15439872
86RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14901078
87* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14308778
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12325629
89SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.10736261
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10291936
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10195957
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09630190
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09577583
94* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09161589
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09060314
96KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08336385
97ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08101921
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07626960
99* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06872460
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06124507
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05856784
102* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.05753862
103ELK3_25401928_ChIP-Seq_HUVEC_Human1.05686579
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04909038
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04387716
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03984180
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03535821
108VDR_21846776_ChIP-Seq_THP-1_Human1.03446377
109CHD1_26751641_Chip-Seq_LNCaP_Human1.03440514
110CREB1_26743006_Chip-Seq_LNCaP_Human1.03154908
111TBX5_21415370_ChIP-Seq_HL-1_Mouse1.03138199
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02689718
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02684809
114DCP1A_22483619_ChIP-Seq_HELA_Human1.02423091
115TCF7_22412390_ChIP-Seq_EML_Mouse1.02365530
116GABP_19822575_ChIP-Seq_HepG2_Human1.02247492
117UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00374592
118THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99056565
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98963051
120KDM2B_26808549_Chip-Seq_DND41_Human0.98947070
121SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98275687
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.98158025
123* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98140587
124ESR2_21235772_ChIP-Seq_MCF-7_Human0.97952804
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97869955
126RARB_27405468_Chip-Seq_BRAIN_Mouse0.96177250
127RACK7_27058665_Chip-Seq_MCF-7_Human0.95784088
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.95495432
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94792459
130CIITA_25753668_ChIP-Seq_RAJI_Human0.94056797
131KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93312947
132TP53_22127205_ChIP-Seq_IMR90_Human0.89629192
133TTF2_22483619_ChIP-Seq_HELA_Human0.89333453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.63920602
2MP0003806_abnormal_nucleotide_metabolis3.56642807
3MP0010352_gastrointestinal_tract_polyps3.38920778
4MP0002139_abnormal_hepatobiliary_system3.19149922
5MP0008438_abnormal_cutaneous_collagen2.79669510
6MP0003283_abnormal_digestive_organ2.58542030
7MP0003111_abnormal_nucleus_morphology2.55939055
8MP0005360_urolithiasis2.47328107
9MP0004957_abnormal_blastocyst_morpholog2.47245332
10MP0010307_abnormal_tumor_latency2.46816143
11MP0005076_abnormal_cell_differentiation2.45756128
12MP0001730_embryonic_growth_arrest2.27772379
13MP0004859_abnormal_synaptic_plasticity2.21299250
14MP0005085_abnormal_gallbladder_physiolo2.13621358
15MP0003693_abnormal_embryo_hatching2.10228931
16MP0010234_abnormal_vibrissa_follicle2.10177699
17MP0005623_abnormal_meninges_morphology2.08088773
18MP0003566_abnormal_cell_adhesion2.05833010
19MP0009840_abnormal_foam_cell2.01056871
20MP0010094_abnormal_chromosome_stability1.98742456
21MP0003941_abnormal_skin_development1.97493740
22MP0003077_abnormal_cell_cycle1.97168049
23MP0005365_abnormal_bile_salt1.96537698
24MP0004197_abnormal_fetal_growth/weight/1.93271997
25MP0002877_abnormal_melanocyte_morpholog1.92263162
26MP0005083_abnormal_biliary_tract1.88835417
27MP0003252_abnormal_bile_duct1.84914272
28MP0000350_abnormal_cell_proliferation1.81201772
29MP0005451_abnormal_body_composition1.80590858
30MP0009053_abnormal_anal_canal1.79644301
31MP0004233_abnormal_muscle_weight1.71195592
32MP0002084_abnormal_developmental_patter1.70603784
33MP0003123_paternal_imprinting1.66978743
34MP0005023_abnormal_wound_healing1.66470554
35MP0005380_embryogenesis_phenotype1.62837639
36MP0001672_abnormal_embryogenesis/_devel1.62837639
37MP0001697_abnormal_embryo_size1.58102626
38MP0000537_abnormal_urethra_morphology1.53636445
39MP0002086_abnormal_extraembryonic_tissu1.51806024
40MP0002080_prenatal_lethality1.51291162
41MP0004270_analgesia1.50891713
42MP0002088_abnormal_embryonic_growth/wei1.50516010
43MP0000678_abnormal_parathyroid_gland1.50441775
44MP0003984_embryonic_growth_retardation1.50282736
45MP0000579_abnormal_nail_morphology1.49696570
46MP0002085_abnormal_embryonic_tissue1.49071453
47MP0001849_ear_inflammation1.46661600
48MP0005501_abnormal_skin_physiology1.43778855
49MP0003119_abnormal_digestive_system1.39863983
50MP0002653_abnormal_ependyma_morphology1.38874312
51MP0009780_abnormal_chondrocyte_physiolo1.37169781
52MP0009672_abnormal_birth_weight1.36868567
53MP0010030_abnormal_orbit_morphology1.32093170
54MP0004185_abnormal_adipocyte_glucose1.29063003
55MP0000733_abnormal_muscle_development1.29046199
56MP0004264_abnormal_extraembryonic_tissu1.28671471
57MP0005275_abnormal_skin_tensile1.26830307
58MP0002796_impaired_skin_barrier1.26225700
59MP0008932_abnormal_embryonic_tissue1.25924610
60MP0000566_synostosis1.25868006
61MP0010329_abnormal_lipoprotein_level1.25226334
62MP0004147_increased_porphyrin_level1.25174088
63MP0008007_abnormal_cellular_replicative1.24182125
64MP0002269_muscular_atrophy1.24169356
65MP0002089_abnormal_postnatal_growth/wei1.24101159
66MP0003890_abnormal_embryonic-extraembry1.23197253
67MP0003656_abnormal_erythrocyte_physiolo1.21504376
68MP0001346_abnormal_lacrimal_gland1.20699728
69MP0001915_intracranial_hemorrhage1.16498021
70MP0003091_abnormal_cell_migration1.15744651
71MP0001661_extended_life_span1.14650307
72MP0004133_heterotaxia1.11629052
73MP0003115_abnormal_respiratory_system1.06381222
74MP0003942_abnormal_urinary_system1.06100584
75MP0000358_abnormal_cell_content/1.03575556
76MP0008058_abnormal_DNA_repair1.03163269
77MP0009703_decreased_birth_body1.02596320
78MP0002697_abnormal_eye_size1.01994733
79MP0003385_abnormal_body_wall1.00070912
80MP0002060_abnormal_skin_morphology1.00048920
81MP0000609_abnormal_liver_physiology0.99498219
82MP0008875_abnormal_xenobiotic_pharmacok0.99369616
83MP0003453_abnormal_keratinocyte_physiol0.98963228
84MP0000747_muscle_weakness0.98125225
85MP0002111_abnormal_tail_morphology0.96189585
86MP0008770_decreased_survivor_rate0.96126294
87MP0000598_abnormal_liver_morphology0.95699649
88MP0002249_abnormal_larynx_morphology0.95454619
89MP0000428_abnormal_craniofacial_morphol0.93361605
90MP0004782_abnormal_surfactant_physiolog0.92973747
91MP0005409_darkened_coat_color0.92729478
92MP0001348_abnormal_lacrimal_gland0.92172058
93MP0003634_abnormal_glial_cell0.89814487
94MP0000751_myopathy0.88374444
95MP0008260_abnormal_autophagy0.85915276
96MP0005621_abnormal_cell_physiology0.84786540
97MP0002092_abnormal_eye_morphology0.83744896
98MP0005666_abnormal_adipose_tissue0.83406659
99MP0005257_abnormal_intraocular_pressure0.80492253
100MP0000467_abnormal_esophagus_morphology0.80225768
101MP0005384_cellular_phenotype0.79217383
102MP0005332_abnormal_amino_acid0.78719834
103MP0003300_gastrointestinal_ulcer0.77413820
104MP0000534_abnormal_ureter_morphology0.77188459
105MP0004087_abnormal_muscle_fiber0.77001155
106MP0002896_abnormal_bone_mineralization0.76668061
107MP0005423_abnormal_somatic_nervous0.76361466
108MP0004811_abnormal_neuron_physiology0.76269149
109MP0003221_abnormal_cardiomyocyte_apopto0.76063967
110MP0010630_abnormal_cardiac_muscle0.74342064
111MP0001881_abnormal_mammary_gland0.73413903
112MP0001293_anophthalmia0.73262209
113MP0004808_abnormal_hematopoietic_stem0.72680848
114MP0005503_abnormal_tendon_morphology0.72408011
115MP0004272_abnormal_basement_membrane0.72283877
116MP0005266_abnormal_metabolism0.72244358
117MP0004858_abnormal_nervous_system0.72165528
118MP0008057_abnormal_DNA_replication0.71841971
119MP0005375_adipose_tissue_phenotype0.71717372
120MP0005187_abnormal_penis_morphology0.71301468
121MP0000003_abnormal_adipose_tissue0.71157841
122MP0000627_abnormal_mammary_gland0.70832789
123MP0000371_diluted_coat_color0.70711817
124MP0005319_abnormal_enzyme/_coenzyme0.70493164
125MP0008569_lethality_at_weaning0.70323470
126MP0005058_abnormal_lysosome_morphology0.70228468
127* MP0000377_abnormal_hair_follicle0.69579715
128MP0003567_abnormal_fetal_cardiomyocyte0.69393373
129MP0001299_abnormal_eye_distance/0.69318434
130MP0003279_aneurysm0.69101966
131MP0008961_abnormal_basal_metabolism0.68975189
132MP0003937_abnormal_limbs/digits/tail_de0.67882013
133MP0003172_abnormal_lysosome_physiology0.67671309
134MP0000313_abnormal_cell_death0.67474532
135MP0003861_abnormal_nervous_system0.66701946
136MP0001243_abnormal_dermal_layer0.64498148
137MP0002081_perinatal_lethality0.64462366
138MP0006054_spinal_hemorrhage0.63003236
139MP0003329_amyloid_beta_deposits0.62627095
140MP0003868_abnormal_feces_composition0.62527525

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.05417072
2Ependymoma (HP:0002888)3.97142362
3Astrocytoma (HP:0009592)3.54421819
4Abnormality of the astrocytes (HP:0100707)3.54421819
5Spastic diplegia (HP:0001264)3.50188621
6Abnormality of the lower motor neuron (HP:0002366)3.44354136
7Hand muscle atrophy (HP:0009130)3.32868027
8Upper limb muscle weakness (HP:0003484)3.26324536
9Premature rupture of membranes (HP:0001788)3.23139328
10Upper limb amyotrophy (HP:0009129)3.22074885
11Distal upper limb amyotrophy (HP:0007149)3.22074885
12Abnormality of monocarboxylic acid metabolism (HP:0010996)3.19898180
13Deep venous thrombosis (HP:0002625)3.11993592
14Intrahepatic cholestasis (HP:0001406)2.82616142
15Ankyloglossia (HP:0010296)2.81113623
16Shallow orbits (HP:0000586)2.80129834
17Back pain (HP:0003418)2.78815993
18Ankle contracture (HP:0006466)2.76190252
19Abnormality of the Achilles tendon (HP:0005109)2.72259397
20Cortical dysplasia (HP:0002539)2.70541010
21Cerebral aneurysm (HP:0004944)2.69828696
22Genu recurvatum (HP:0002816)2.67741302
23Pseudobulbar signs (HP:0002200)2.66253627
24Abnormality of glycolysis (HP:0004366)2.64965068
25Achilles tendon contracture (HP:0001771)2.59694816
26Hypobetalipoproteinemia (HP:0003563)2.56616450
27Xanthomatosis (HP:0000991)2.54128552
28Glioma (HP:0009733)2.53100167
29Overriding aorta (HP:0002623)2.51884249
30Long palpebral fissure (HP:0000637)2.41816603
31Abnormality of reticulocytes (HP:0004312)2.40942431
32Cholelithiasis (HP:0001081)2.40401616
33Bowel diverticulosis (HP:0005222)2.39394073
34Elfin facies (HP:0004428)2.38144852
35Angiofibromas (HP:0010615)2.32505348
36Adenoma sebaceum (HP:0009720)2.32505348
37Abnormality of pyrimidine metabolism (HP:0004353)2.31321092
38Overlapping toe (HP:0001845)2.25426228
39Renal duplication (HP:0000075)2.24714381
40Abnormality of the labia minora (HP:0012880)2.23562179
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.20090982
42Selective tooth agenesis (HP:0001592)2.20071702
43Abnormality of oral frenula (HP:0000190)2.15516174
44Cervical subluxation (HP:0003308)2.14434876
45Truncus arteriosus (HP:0001660)2.13914610
46Chromsome breakage (HP:0040012)2.13744326
47Pointed chin (HP:0000307)2.13185708
48Peritonitis (HP:0002586)2.12901607
49Resting tremor (HP:0002322)2.12228773
50Abnormality of sulfur amino acid metabolism (HP:0004339)2.11713754
51Hypolipoproteinemia (HP:0010981)2.11421568
52Abnormal gallbladder morphology (HP:0012437)2.09170111
53Reticulocytosis (HP:0001923)2.08140306
54Deviation of the thumb (HP:0009603)2.07744422
55Fibroma (HP:0010614)2.06980670
56Progressive muscle weakness (HP:0003323)2.05933241
57Hypopigmentation of the fundus (HP:0007894)2.05300776
58Abnormality of the calcaneus (HP:0008364)2.03645383
59Bladder diverticulum (HP:0000015)2.02907563
60Ulnar bowing (HP:0003031)2.02756939
61Breech presentation (HP:0001623)2.02660518
62Hyperacusis (HP:0010780)2.02360887
63Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01078716
64Rhabdomyosarcoma (HP:0002859)2.00107730
65Global brain atrophy (HP:0002283)1.98871573
66Asymmetry of the thorax (HP:0001555)1.98829771
67Turricephaly (HP:0000262)1.97616129
68Biliary tract neoplasm (HP:0100574)1.95952675
69Proximal placement of thumb (HP:0009623)1.95943926
70Hypoalphalipoproteinemia (HP:0003233)1.95534071
71Bowel incontinence (HP:0002607)1.95401408
72* Hammertoe (HP:0001765)1.94813321
73Cerebral inclusion bodies (HP:0100314)1.94688739
74Fibrous tissue neoplasm (HP:0012316)1.94584004
75Mitral valve prolapse (HP:0001634)1.93923375
76Heterotopia (HP:0002282)1.93609414
77Vertebral compression fractures (HP:0002953)1.93268907
78Patellar dislocation (HP:0002999)1.93256667
79Disproportionate tall stature (HP:0001519)1.91221411
80Sparse lateral eyebrow (HP:0005338)1.91158945
81Flat cornea (HP:0007720)1.91109371
82Hyperthyroidism (HP:0000836)1.90883584
83Vertebral clefting (HP:0008428)1.90525698
84Multiple enchondromatosis (HP:0005701)1.89904845
85Missing ribs (HP:0000921)1.89637285
86Biconcave vertebral bodies (HP:0004586)1.88467668
87Difficulty climbing stairs (HP:0003551)1.88174692
88Unilateral renal agenesis (HP:0000122)1.88043259
89Metaphyseal cupping (HP:0003021)1.87118388
90Aneurysm (HP:0002617)1.86904404
91Peripheral hypomyelination (HP:0007182)1.86868229
92Abnormality of the anterior horn cell (HP:0006802)1.86751454
93Degeneration of anterior horn cells (HP:0002398)1.86751454
94Abnormality of the gallbladder (HP:0005264)1.86358844
95Increased serum pyruvate (HP:0003542)1.86346505
96Neoplasm of the oral cavity (HP:0100649)1.86031970
97Abnormal neuron morphology (HP:0012757)1.84939931
98Abnormality of the motor neurons (HP:0002450)1.84939931
99Dilatation of the ascending aorta (HP:0005111)1.84745257
100Advanced eruption of teeth (HP:0006288)1.84619802
101Increased connective tissue (HP:0009025)1.84279831
102Short humerus (HP:0005792)1.83762672
103Skin nodule (HP:0200036)1.83522989
104Medulloblastoma (HP:0002885)1.83222061
105Renovascular hypertension (HP:0100817)1.82392714
106Urethral obstruction (HP:0000796)1.82141317
107Abnormality of aromatic amino acid family metabolism (HP:0004338)1.81458396
108Progressive external ophthalmoplegia (HP:0000590)1.81438598
109Neoplasm of striated muscle (HP:0009728)1.81304678
110Pelvic girdle muscle weakness (HP:0003749)1.81043609
111Increased density of long bones (HP:0006392)1.80334227
112Septate vagina (HP:0001153)1.80086398
113Lower limb amyotrophy (HP:0007210)1.79956148
114Upper motor neuron abnormality (HP:0002127)1.79951201
115Abnormal cartilage morphology (HP:0002763)1.79781545
116Centrally nucleated skeletal muscle fibers (HP:0003687)1.79780605
117Abnormal large intestine physiology (HP:0012700)1.78930357
118Deep palmar crease (HP:0006191)1.78203604
119Wrist flexion contracture (HP:0001239)1.77614376
120Pterygium (HP:0001059)1.77173117
121Shoulder girdle muscle weakness (HP:0003547)1.76309345
122Aplasia/hypoplasia of the humerus (HP:0006507)1.76211821
123Large hands (HP:0001176)1.75503150
124Distal lower limb amyotrophy (HP:0008944)1.75351074
125Insomnia (HP:0100785)1.74708696
126Relative macrocephaly (HP:0004482)1.73422682
127Cutaneous melanoma (HP:0012056)1.73378170
128Abnormality of the salivary glands (HP:0010286)1.73225353
129Impaired pain sensation (HP:0007328)1.71872792
130Abnormality of pain sensation (HP:0010832)1.71872792
131Premature skin wrinkling (HP:0100678)1.71662691
132Trismus (HP:0000211)1.70670698
133Microvesicular hepatic steatosis (HP:0001414)1.69491030
134Hepatocellular carcinoma (HP:0001402)1.69399795
135Atrophy/Degeneration involving motor neurons (HP:0007373)1.67857459
136Epidermoid cyst (HP:0200040)1.67347645
137Increased nuchal translucency (HP:0010880)1.66536744
138* Distal sensory impairment (HP:0002936)1.65360402
139Abnormal gallbladder physiology (HP:0012438)1.65029221
140Cholecystitis (HP:0001082)1.65029221
141Macroorchidism (HP:0000053)1.64359673
142Abnormality of cochlea (HP:0000375)1.64212808
143Hyperglycinemia (HP:0002154)1.64181266
144Obsessive-compulsive behavior (HP:0000722)1.63224933
145Broad face (HP:0000283)1.63217435
146Malignant gastrointestinal tract tumors (HP:0006749)1.63175446
147Gastrointestinal carcinoma (HP:0002672)1.63175446
148Dysmetric saccades (HP:0000641)1.61718899
149Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61413715
150Obstructive sleep apnea (HP:0002870)1.61037806
151Termporal pattern (HP:0011008)1.60901569
152Insidious onset (HP:0003587)1.60901569
153Subacute progressive viral hepatitis (HP:0006572)1.60602116
154Orthostatic hypotension (HP:0001278)1.60470215
155Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.60217165
156Enlarged penis (HP:0000040)1.59414288
157Abnormality of dentin (HP:0010299)1.58586765
158Vertebral arch anomaly (HP:0008438)1.58371939
159Precocious puberty (HP:0000826)1.58286106
160Abnormality of the peritoneum (HP:0002585)1.58209055
161Blue sclerae (HP:0000592)1.57125485
162Abnormality of the common coagulation pathway (HP:0010990)1.56764171
163Lymphangioma (HP:0100764)1.56716273
164Complement deficiency (HP:0004431)1.55845639
165Attention deficit hyperactivity disorder (HP:0007018)1.54088745
166Depression (HP:0000716)1.51145011
167Abnormality of the tricuspid valve (HP:0001702)1.49854697
168Birth length less than 3rd percentile (HP:0003561)1.49520742

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.44625813
2SMG13.35293084
3EEF2K3.31716360
4TRIB33.19545458
5NEK13.11873856
6EPHA22.78849727
7CDK122.71352810
8CDC72.52102591
9SCYL22.36416998
10LATS22.25542634
11NEK22.00857322
12WEE11.91021954
13MAP3K101.83121349
14TTN1.82350793
15TTK1.78008314
16PDGFRA1.77883262
17ALK1.75003057
18PRPF4B1.71245699
19IRAK31.71141788
20BUB11.61540692
21TSSK61.60667891
22BMX1.60414662
23MST1R1.57761580
24TESK21.56593559
25PASK1.55525290
26DDR21.47977225
27RPS6KB21.46707042
28PAK41.43254474
29MTOR1.42512235
30LATS11.40259221
31MAP3K81.39629773
32ICK1.39201733
33ERN11.36410598
34SIK11.35158845
35MET1.32422311
36PTK61.31311752
37LMTK21.29767324
38FLT31.25633664
39PNCK1.23153415
40RIPK11.21599397
41NME21.19300014
42MAP3K91.17606993
43KSR21.15084491
44ARAF1.11481509
45PAK21.11448736
46PBK1.06228306
47BRAF1.04905999
48PTK21.04079667
49PAK61.03211124
50CDK41.01139186
51PLK11.00727830
52EIF2AK10.97866259
53ERBB40.96752310
54PDK40.94681297
55PDK30.94681297
56CDK60.94613149
57CHEK10.92836023
58BCKDK0.92827160
59FGFR10.92676413
60TESK10.90279212
61TLK10.88725618
62SRPK10.87172949
63PLK30.86802836
64AURKA0.85892632
65LRRK20.85846381
66CAMK1G0.84795296
67CDK70.82246233
68PRKD30.79954440
69STK100.79249028
70KSR10.77036623
71ATR0.75627265
72AURKB0.74954993
73BRD40.74074080
74CDK20.72628775
75RAF10.72393549
76RPS6KA40.69784856
77TYRO30.68851044
78FGFR40.68622180
79CSNK1E0.68292231
80MAPKAPK30.68156137
81FER0.66755917
82NTRK30.65796871
83RET0.63462490
84MAP3K130.61651960
85CLK10.61056981
86PAK10.60573885
87AKT20.60536212
88CAMK1D0.60376674
89CHEK20.60336714
90CDK80.60050037
91PAK30.57161435
92CSNK1D0.57129496
93MAPK110.56232760
94DAPK10.55610898
95TAF10.55505351
96VRK20.52535543
97ATM0.52102987
98MAPK100.51781696
99MAP3K20.51011031
100STK30.50706120
101PRKCI0.50517688
102BRSK10.49971428
103CDK10.49039265
104NTRK10.47359025
105CAMKK10.47017362
106PIM20.46982754
107PDK20.46932487
108UHMK10.46356946
109MAPKAPK50.46065961
110CDK150.45886162
111PDGFRB0.44545560
112NEK60.44490062
113RPS6KB10.44446668
114PRKDC0.44228506
115LIMK10.42936467
116CDK140.41495186
117SIK20.40909468
118TGFBR10.40758913
119MAP2K10.40562547
120TAOK10.40460413
121DYRK1B0.39896344
122WNK10.39850900
123CDK90.39001098
124CDK180.38931352
125CDK11A0.38743023
126GSK3B0.36588729
127STK380.36564859
128RPS6KA20.36470781
129BRSK20.35574643
130MAP2K30.35375627
131DAPK30.34309388
132CSNK2A20.34030715

Predicted pathways (KEGG)

RankGene SetZ-score
1One carbon pool by folate_Homo sapiens_hsa006703.98638328
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.72043980
3Nitrogen metabolism_Homo sapiens_hsa009103.43984609
4* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.89643947
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67741976
6Biosynthesis of amino acids_Homo sapiens_hsa012302.59011185
7Arginine biosynthesis_Homo sapiens_hsa002202.44516612
8Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.39061109
9Selenocompound metabolism_Homo sapiens_hsa004502.37586890
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.26463715
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12200977
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.10908119
13Cyanoamino acid metabolism_Homo sapiens_hsa004601.98337932
14RNA transport_Homo sapiens_hsa030131.97744771
15Carbon metabolism_Homo sapiens_hsa012001.80497409
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79630141
17Cysteine and methionine metabolism_Homo sapiens_hsa002701.70188474
18DNA replication_Homo sapiens_hsa030301.60879474
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.59421793
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.54234194
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46266032
22Mismatch repair_Homo sapiens_hsa034301.45529407
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.37604331
24Tryptophan metabolism_Homo sapiens_hsa003801.27609765
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.26558885
26Bladder cancer_Homo sapiens_hsa052191.23201191
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21914562
28Pyruvate metabolism_Homo sapiens_hsa006201.21846111
29Cell cycle_Homo sapiens_hsa041101.18188199
30mTOR signaling pathway_Homo sapiens_hsa041501.17350661
31Lysine degradation_Homo sapiens_hsa003101.13074222
32Systemic lupus erythematosus_Homo sapiens_hsa053221.12095684
33Vitamin B6 metabolism_Homo sapiens_hsa007501.11990365
34Spliceosome_Homo sapiens_hsa030401.08413348
35Fatty acid degradation_Homo sapiens_hsa000711.05527179
36mRNA surveillance pathway_Homo sapiens_hsa030151.05213669
37Complement and coagulation cascades_Homo sapiens_hsa046101.04053781
38ErbB signaling pathway_Homo sapiens_hsa040121.02855544
39Butanoate metabolism_Homo sapiens_hsa006501.01607695
40Synaptic vesicle cycle_Homo sapiens_hsa047210.99976659
41Pentose phosphate pathway_Homo sapiens_hsa000300.99108959
42N-Glycan biosynthesis_Homo sapiens_hsa005100.98555467
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.96549401
44Long-term potentiation_Homo sapiens_hsa047200.96087252
45Bile secretion_Homo sapiens_hsa049760.95349836
46Viral carcinogenesis_Homo sapiens_hsa052030.95101516
47Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.94474317
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90212257
49Steroid biosynthesis_Homo sapiens_hsa001000.89020559
50Vibrio cholerae infection_Homo sapiens_hsa051100.85235950
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83469576
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82220613
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81528954
54MicroRNAs in cancer_Homo sapiens_hsa052060.81433612
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81214512
56Hippo signaling pathway_Homo sapiens_hsa043900.79858264
57Pancreatic cancer_Homo sapiens_hsa052120.78874408
58p53 signaling pathway_Homo sapiens_hsa041150.77544463
59Thyroid hormone synthesis_Homo sapiens_hsa049180.77234842
60VEGF signaling pathway_Homo sapiens_hsa043700.76776471
61Nucleotide excision repair_Homo sapiens_hsa034200.75614990
62Fat digestion and absorption_Homo sapiens_hsa049750.75253474
63Sulfur relay system_Homo sapiens_hsa041220.74036896
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73384647
65Fatty acid metabolism_Homo sapiens_hsa012120.72430025
66Fructose and mannose metabolism_Homo sapiens_hsa000510.71535017
67Oocyte meiosis_Homo sapiens_hsa041140.71434900
68PPAR signaling pathway_Homo sapiens_hsa033200.69835075
69Chronic myeloid leukemia_Homo sapiens_hsa052200.69432163
70Non-homologous end-joining_Homo sapiens_hsa034500.69064694
71Arginine and proline metabolism_Homo sapiens_hsa003300.68145561
72Prion diseases_Homo sapiens_hsa050200.67733372
73Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67674343
74Proteoglycans in cancer_Homo sapiens_hsa052050.66730599
75AMPK signaling pathway_Homo sapiens_hsa041520.66098547
76Phenylalanine metabolism_Homo sapiens_hsa003600.65952434
77Acute myeloid leukemia_Homo sapiens_hsa052210.65819437
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64853768
79Glucagon signaling pathway_Homo sapiens_hsa049220.62694397
80Adherens junction_Homo sapiens_hsa045200.62229823
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60699782
82Folate biosynthesis_Homo sapiens_hsa007900.59867249
83Inositol phosphate metabolism_Homo sapiens_hsa005620.57905650
84Tyrosine metabolism_Homo sapiens_hsa003500.57011494
85Insulin resistance_Homo sapiens_hsa049310.56719903
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.54984944
87Glioma_Homo sapiens_hsa052140.53991901
88Small cell lung cancer_Homo sapiens_hsa052220.52445005
89Insulin signaling pathway_Homo sapiens_hsa049100.52225363
90Focal adhesion_Homo sapiens_hsa045100.50818575
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50105520
92Base excision repair_Homo sapiens_hsa034100.48843950
93Tight junction_Homo sapiens_hsa045300.48109835
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47540590
95Melanogenesis_Homo sapiens_hsa049160.46878297
96Endometrial cancer_Homo sapiens_hsa052130.45065305
97Propanoate metabolism_Homo sapiens_hsa006400.44869131
98Notch signaling pathway_Homo sapiens_hsa043300.43580097
99Galactose metabolism_Homo sapiens_hsa000520.43565406
100HIF-1 signaling pathway_Homo sapiens_hsa040660.42252219
101Choline metabolism in cancer_Homo sapiens_hsa052310.41986905
102Non-small cell lung cancer_Homo sapiens_hsa052230.41677192
103Basal cell carcinoma_Homo sapiens_hsa052170.40866913
104Fatty acid biosynthesis_Homo sapiens_hsa000610.40778249
105Alcoholism_Homo sapiens_hsa050340.40692607
106Thyroid cancer_Homo sapiens_hsa052160.40255524
107Wnt signaling pathway_Homo sapiens_hsa043100.38950632
108Starch and sucrose metabolism_Homo sapiens_hsa005000.38470735
109Gap junction_Homo sapiens_hsa045400.37752510
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37729114
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37520710
112Melanoma_Homo sapiens_hsa052180.36332229
113GnRH signaling pathway_Homo sapiens_hsa049120.36310536
114HTLV-I infection_Homo sapiens_hsa051660.35558509
115Estrogen signaling pathway_Homo sapiens_hsa049150.35079216
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.34808500
117ECM-receptor interaction_Homo sapiens_hsa045120.33181663
118Chemical carcinogenesis_Homo sapiens_hsa052040.32074415
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31937584
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.31745348
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31075848
122Pyrimidine metabolism_Homo sapiens_hsa002400.30517229
123Colorectal cancer_Homo sapiens_hsa052100.30083756
124Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29997043
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29824514
126Prostate cancer_Homo sapiens_hsa052150.28904228
127Renal cell carcinoma_Homo sapiens_hsa052110.28212069

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