AARS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycine metabolic process (GO:0006544)4.88525049
2mitotic sister chromatid segregation (GO:0000070)4.56293153
3folic acid-containing compound biosynthetic process (GO:0009396)4.45786365
4nuclear pore complex assembly (GO:0051292)4.43724569
5lysine catabolic process (GO:0006554)4.36265817
6lysine metabolic process (GO:0006553)4.36265817
7spliceosomal tri-snRNP complex assembly (GO:0000244)4.28370953
8telomere maintenance via semi-conservative replication (GO:0032201)4.21003235
9DNA unwinding involved in DNA replication (GO:0006268)4.11932280
10sister chromatid segregation (GO:0000819)4.00544901
11regulation of translational fidelity (GO:0006450)3.99899293
12L-phenylalanine metabolic process (GO:0006558)3.98715425
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.98715425
14DNA replication checkpoint (GO:0000076)3.98358831
15aspartate family amino acid catabolic process (GO:0009068)3.92173194
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.91094892
17glyoxylate metabolic process (GO:0046487)3.90513709
18DNA topological change (GO:0006265)3.89504754
19serine family amino acid biosynthetic process (GO:0009070)3.84837987
20nuclear pore organization (GO:0006999)3.80995602
21serine family amino acid metabolic process (GO:0009069)3.77528558
22serine family amino acid catabolic process (GO:0009071)3.77094028
23chromatin assembly (GO:0031497)3.70000437
24ribosome biogenesis (GO:0042254)3.67042656
25telomere maintenance via recombination (GO:0000722)3.62462823
26histone arginine methylation (GO:0034969)3.62248092
27pore complex assembly (GO:0046931)3.60378015
28IMP biosynthetic process (GO:0006188)3.56083322
292-oxoglutarate metabolic process (GO:0006103)3.55646588
30mitotic chromosome condensation (GO:0007076)3.53449678
31* mitochondrial RNA metabolic process (GO:0000959)3.53155710
32nucleobase biosynthetic process (GO:0046112)3.52636238
33erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.52575020
34L-phenylalanine catabolic process (GO:0006559)3.52575020
35snRNA metabolic process (GO:0016073)3.51653659
36L-serine metabolic process (GO:0006563)3.51419389
37snRNA processing (GO:0016180)3.44643677
38maternal placenta development (GO:0001893)3.43684450
39mitotic G1 DNA damage checkpoint (GO:0031571)3.43413893
40protein-DNA complex disassembly (GO:0032986)3.43249169
41nucleosome disassembly (GO:0006337)3.43249169
42kynurenine metabolic process (GO:0070189)3.41660297
43dosage compensation (GO:0007549)3.40046716
44rRNA transcription (GO:0009303)3.39517734
45regulation of mammary gland epithelial cell proliferation (GO:0033599)3.38973662
46translesion synthesis (GO:0019985)3.38927985
47mitotic nuclear envelope disassembly (GO:0007077)3.38708330
48folic acid metabolic process (GO:0046655)3.37661380
49tricarboxylic acid cycle (GO:0006099)3.36368431
50sulfur amino acid catabolic process (GO:0000098)3.34680282
51DNA conformation change (GO:0071103)3.34043893
52chaperone-mediated protein complex assembly (GO:0051131)3.33161911
53IMP metabolic process (GO:0046040)3.29590488
54regulation of translational termination (GO:0006449)3.29075010
55dicarboxylic acid biosynthetic process (GO:0043650)3.28592518
56protein localization to kinetochore (GO:0034501)3.28050429
57tetrahydrofolate metabolic process (GO:0046653)3.25465611
58mitotic recombination (GO:0006312)3.24846777
59cysteine metabolic process (GO:0006534)3.22531742
60acetyl-CoA metabolic process (GO:0006084)3.22449935
61regulation of posttranscriptional gene silencing (GO:0060147)3.22090371
62regulation of gene silencing by miRNA (GO:0060964)3.22090371
63regulation of gene silencing by RNA (GO:0060966)3.22090371
64tRNA methylation (GO:0030488)3.18450390
65regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18157654
66negative regulation of fatty acid biosynthetic process (GO:0045717)3.17813536
67negative regulation of mRNA processing (GO:0050686)3.17671422
68nucleotide-excision repair, DNA gap filling (GO:0006297)3.15001086
69purine nucleobase biosynthetic process (GO:0009113)3.14561533
70proline metabolic process (GO:0006560)3.12926956
71regulation of nuclear cell cycle DNA replication (GO:0033262)3.12342975
72alpha-linolenic acid metabolic process (GO:0036109)3.11562256
73carnitine shuttle (GO:0006853)3.10887196
74positive regulation of cell cycle checkpoint (GO:1901978)3.10279764
75viral mRNA export from host cell nucleus (GO:0046784)3.08681337
76regulation of cholesterol homeostasis (GO:2000188)3.07430875
77urea cycle (GO:0000050)3.07293530
78urea metabolic process (GO:0019627)3.07293530
79homocysteine metabolic process (GO:0050667)3.06973388
80membrane disassembly (GO:0030397)3.06220857
81nuclear envelope disassembly (GO:0051081)3.06220857
82DNA replication-dependent nucleosome assembly (GO:0006335)3.06140550
83DNA replication-dependent nucleosome organization (GO:0034723)3.06140550
84transcription from mitochondrial promoter (GO:0006390)3.06104284
85amino-acid betaine metabolic process (GO:0006577)3.06059498
86maturation of 5.8S rRNA (GO:0000460)3.05631257
87one-carbon metabolic process (GO:0006730)3.04855539
88triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.04532627
89base-excision repair (GO:0006284)3.03114753
90peptidyl-arginine N-methylation (GO:0035246)3.02315395
91peptidyl-arginine methylation (GO:0018216)3.02315395
92pre-miRNA processing (GO:0031054)3.01594808
93proline biosynthetic process (GO:0006561)3.01174168
94alpha-amino acid catabolic process (GO:1901606)3.00750790
95double-strand break repair via nonhomologous end joining (GO:0006303)3.00563572
96non-recombinational repair (GO:0000726)3.00563572
97DNA replication initiation (GO:0006270)2.99961659
98formation of translation preinitiation complex (GO:0001731)2.98719562
99negative regulation of cell cycle G2/M phase transition (GO:1902750)2.96227097
100ethanol oxidation (GO:0006069)2.95515906
101DNA strand elongation involved in DNA replication (GO:0006271)2.94854470
102meiotic chromosome segregation (GO:0045132)2.93236693
103mitotic G1/S transition checkpoint (GO:0044819)2.92540420
104negative regulation of fibrinolysis (GO:0051918)2.92222779
105fatty acid transmembrane transport (GO:1902001)2.92161170
106aromatic amino acid family catabolic process (GO:0009074)2.91626015
107pentose-phosphate shunt (GO:0006098)2.91310701
108tricarboxylic acid metabolic process (GO:0072350)2.91180224
109pteridine-containing compound biosynthetic process (GO:0042559)2.91111161
110peptidyl-arginine omega-N-methylation (GO:0035247)2.87887124
111negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.87776469
112DNA ligation (GO:0006266)2.85950732
113negative regulation of mRNA metabolic process (GO:1903312)2.85213854
114negative regulation of histone methylation (GO:0031061)2.84765271
115regulation of histone H3-K4 methylation (GO:0051569)2.84295721
116cellular amino acid catabolic process (GO:0009063)2.84282685
117chromatin assembly or disassembly (GO:0006333)2.83042512
118ribonucleoprotein complex biogenesis (GO:0022613)2.82574657
119peptidyl-lysine dimethylation (GO:0018027)2.81225758
120tRNA modification (GO:0006400)2.81032558
121pseudouridine synthesis (GO:0001522)2.80095947
122DNA duplex unwinding (GO:0032508)2.78914499
123glutamate metabolic process (GO:0006536)2.78770751
124bile acid biosynthetic process (GO:0006699)2.78648208
125oxaloacetate metabolic process (GO:0006107)2.78344856
126* tRNA aminoacylation for protein translation (GO:0006418)2.78060628
127fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.77027663
128nitrogen cycle metabolic process (GO:0071941)2.76399253
129negative regulation of cholesterol transport (GO:0032375)2.76289010
130negative regulation of sterol transport (GO:0032372)2.76289010
131oxidative phosphorylation (GO:0006119)2.76170010
132telomere maintenance via telomere lengthening (GO:0010833)2.76134360
133cellular modified amino acid catabolic process (GO:0042219)2.75906791
134protein complex localization (GO:0031503)2.75432830
135imidazole-containing compound metabolic process (GO:0052803)2.75327077
136pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.74784661
137UMP metabolic process (GO:0046049)2.74784661
138pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.74784661
139UMP biosynthetic process (GO:0006222)2.74784661
140DNA strand elongation (GO:0022616)2.74770969
141DNA geometric change (GO:0032392)2.74334254
142DNA deamination (GO:0045006)2.72609520
143apoptotic process involved in morphogenesis (GO:0060561)2.72443549
144negative regulation of cell size (GO:0045792)2.72135474
145nuclear envelope organization (GO:0006998)2.71976993
146fatty acid homeostasis (GO:0055089)2.71311538
147aspartate family amino acid metabolic process (GO:0009066)2.70858061
148carnitine transmembrane transport (GO:1902603)2.70045062
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.70036777
150somatic diversification of immune receptors via somatic mutation (GO:0002566)2.70036777
151* amino acid activation (GO:0043038)2.69976373
152* tRNA aminoacylation (GO:0043039)2.69976373
153pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.69395019
154positive regulation of DNA-dependent DNA replication (GO:2000105)2.68588550
155mitochondrial DNA metabolic process (GO:0032042)2.68255657
156regulation of fatty acid beta-oxidation (GO:0031998)2.67838001
157folic acid-containing compound metabolic process (GO:0006760)2.67612665
158valine metabolic process (GO:0006573)2.67136778
159positive regulation by host of viral transcription (GO:0043923)2.67089474
160G1 DNA damage checkpoint (GO:0044783)2.66599097
161nuclear envelope reassembly (GO:0031468)2.66454778
162mitotic nuclear envelope reassembly (GO:0007084)2.66454778
163regulation of DNA-dependent DNA replication (GO:0090329)2.66287355
164amino-acid betaine transport (GO:0015838)2.65812533
165carnitine transport (GO:0015879)2.65812533
166glutamine family amino acid biosynthetic process (GO:0009084)2.65398026
167heterochromatin organization (GO:0070828)2.65043437
168negative regulation of gene expression, epigenetic (GO:0045814)2.64929502
169chromosome condensation (GO:0030261)2.64491932
170protein localization to chromosome, centromeric region (GO:0071459)2.64322409
171positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.63396283
172intracellular estrogen receptor signaling pathway (GO:0030520)2.63048869

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.13491037
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90993146
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.59258593
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.17611484
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.87879535
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.71983166
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.45554636
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45005115
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.39613307
10MYC_22102868_ChIP-Seq_BL_Human2.37203562
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18556742
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.17608202
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.12096063
14STAT3_1855785_ChIP-Seq_MESCs_Mouse2.06553222
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.05475412
16ZNF263_19887448_ChIP-Seq_K562_Human2.03886824
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93793814
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.92093228
19XRN2_22483619_ChIP-Seq_HELA_Human1.85208525
20E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77742117
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.77551963
22NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77354224
23VDR_21846776_ChIP-Seq_THP-1_Human1.72492693
24ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.67934549
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64039936
26NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63931711
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.62791209
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.59850672
29* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.57305913
30LXR_22292898_ChIP-Seq_THP-1_Human1.57296160
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.56847042
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56407320
33LXR_22158963_ChIP-Seq_LIVER_Mouse1.56158571
34NELFA_20434984_ChIP-Seq_ESCs_Mouse1.52572504
35CIITA_25753668_ChIP-Seq_RAJI_Human1.50663125
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.49723975
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48014280
38KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.47288984
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.43438348
40* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.42864981
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.42794270
42KLF4_18555785_ChIP-Seq_MESCs_Mouse1.42278084
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42062776
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41683210
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37521212
46ZFX_18555785_ChIP-Seq_MESCs_Mouse1.36910143
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36536153
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36478420
49* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36442035
50AR_21909140_ChIP-Seq_LNCAP_Human1.36083735
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34949228
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34622418
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34408064
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34184509
55ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33191288
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.32843528
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28458181
58E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.28437257
59KDM2B_26808549_Chip-Seq_DND41_Human1.26826963
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26207155
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26028118
62P68_20966046_ChIP-Seq_HELA_Human1.25816177
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.23755101
64CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23713818
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.19780819
66TCF7_22412390_ChIP-Seq_EML_Mouse1.19400284
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19260815
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18229532
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.17959985
70* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.17665438
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17648316
72OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17576634
73KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17061316
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.16764841
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.16321615
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16009216
77KDM5A_27292631_Chip-Seq_BREAST_Human1.15695910
78GABP_19822575_ChIP-Seq_HepG2_Human1.15380651
79PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.14614825
80* SRF_21415370_ChIP-Seq_HL-1_Mouse1.14166278
81* YY1_21170310_ChIP-Seq_MESCs_Mouse1.13307991
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.12492816
83RACK7_27058665_Chip-Seq_MCF-7_Human1.11865375
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.11793037
85NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11500672
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10871620
87* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10192722
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.09892852
89FOXP1_21924763_ChIP-Seq_HESCs_Human1.09167330
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09066854
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.08706245
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08423276
93* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07961705
94BCOR_27268052_Chip-Seq_Bcells_Human1.06088931
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05063365
96ATF3_27146783_Chip-Seq_COLON_Human1.04997632
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.04993424
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04447363
99CTCF_27219007_Chip-Seq_ERYTHROID_Human1.03717310
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03624598
101FOXP3_21729870_ChIP-Seq_TREG_Human1.03547310
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02583184
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02554781
104DCP1A_22483619_ChIP-Seq_HELA_Human1.02103011
105* RARA_24833708_ChIP-Seq_LIVER_Mouse1.01938741
106BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01905049
107* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01572046
108POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01547922
109SOX2_18692474_ChIP-Seq_MESCs_Mouse1.01481281
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.01289758
111SA1_27219007_Chip-Seq_ERYTHROID_Human1.01088861
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.01024002
113SOX2_18555785_ChIP-Seq_MESCs_Mouse1.00762776
114PHF8_20622854_ChIP-Seq_HELA_Human1.00721782
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.00466433
116POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00175765
117* NCOR1_26117541_ChIP-Seq_K562_Human0.99708634
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99675897
119* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99423359
120SMC4_20622854_ChIP-Seq_HELA_Human0.98818076
121CREB1_26743006_Chip-Seq_LNCaP_Human0.98498240
122MAF_26560356_Chip-Seq_TH2_Human0.97739540
123EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97690166
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.96641068
125SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96253353
126* TP53_22127205_ChIP-Seq_IMR90_Human0.96215505
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95844201
128VDR_23849224_ChIP-Seq_CD4+_Human0.94505321
129TTF2_22483619_ChIP-Seq_HELA_Human0.94151838
130CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93931415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.63350913
2MP0005360_urolithiasis4.22495861
3MP0002139_abnormal_hepatobiliary_system4.10998770
4MP0005085_abnormal_gallbladder_physiolo3.59423311
5MP0005365_abnormal_bile_salt3.27946623
6MP0009840_abnormal_foam_cell3.02747825
7MP0003705_abnormal_hypodermis_morpholog2.96100277
8MP0003646_muscle_fatigue2.91400635
9MP0008007_abnormal_cellular_replicative2.89574548
10MP0008058_abnormal_DNA_repair2.48433987
11MP0003693_abnormal_embryo_hatching2.33054061
12MP0003111_abnormal_nucleus_morphology2.32671205
13MP0004957_abnormal_blastocyst_morpholog2.30290590
14MP0009278_abnormal_bone_marrow2.22805388
15MP0002269_muscular_atrophy2.19609892
16MP0005083_abnormal_biliary_tract2.13667178
17MP0004233_abnormal_muscle_weight2.11737075
18MP0010094_abnormal_chromosome_stability2.05527845
19MP0002009_preneoplasia2.02623864
20MP0004084_abnormal_cardiac_muscle1.99190258
21MP0010329_abnormal_lipoprotein_level1.96948385
22MP0001730_embryonic_growth_arrest1.94249932
23MP0008875_abnormal_xenobiotic_pharmacok1.94033599
24MP0002837_dystrophic_cardiac_calcinosis1.93965475
25MP0006036_abnormal_mitochondrial_physio1.91626130
26MP0002653_abnormal_ependyma_morphology1.90972262
27MP0010352_gastrointestinal_tract_polyps1.85284274
28MP0005451_abnormal_body_composition1.80766687
29MP0000751_myopathy1.80271238
30MP0003077_abnormal_cell_cycle1.79918588
31MP0002396_abnormal_hematopoietic_system1.76840188
32MP0006035_abnormal_mitochondrial_morpho1.75516315
33MP0001346_abnormal_lacrimal_gland1.74712778
34MP0005332_abnormal_amino_acid1.73519990
35MP0003252_abnormal_bile_duct1.72736531
36MP0003315_abnormal_perineum_morphology1.71419391
37MP0005330_cardiomyopathy1.66559801
38MP0000747_muscle_weakness1.62989695
39MP0002089_abnormal_postnatal_growth/wei1.58056700
40MP0000537_abnormal_urethra_morphology1.56365374
41MP0003786_premature_aging1.55626830
42MP0005266_abnormal_metabolism1.54174718
43MP0001873_stomach_inflammation1.51938237
44MP0001661_extended_life_span1.51250258
45MP0005670_abnormal_white_adipose1.49884134
46MP0002249_abnormal_larynx_morphology1.48968315
47MP0008057_abnormal_DNA_replication1.48540305
48MP0005058_abnormal_lysosome_morphology1.43008301
49MP0004808_abnormal_hematopoietic_stem1.42873929
50MP0004036_abnormal_muscle_relaxation1.42771562
51MP0004087_abnormal_muscle_fiber1.39966029
52MP0005319_abnormal_enzyme/_coenzyme1.39880658
53MP0005380_embryogenesis_phenotype1.38957082
54MP0001672_abnormal_embryogenesis/_devel1.38957082
55MP0000609_abnormal_liver_physiology1.38570934
56MP0004133_heterotaxia1.37493142
57MP0002080_prenatal_lethality1.30056889
58MP0003984_embryonic_growth_retardation1.29769382
59MP0002088_abnormal_embryonic_growth/wei1.28857435
60MP0001697_abnormal_embryo_size1.28658254
61MP0009333_abnormal_splenocyte_physiolog1.27394425
62MP0000350_abnormal_cell_proliferation1.24570456
63MP0003718_maternal_effect1.24551605
64MP0010630_abnormal_cardiac_muscle1.24409220
65MP0004215_abnormal_myocardial_fiber1.23859276
66MP0000490_abnormal_crypts_of1.22707497
67MP0003221_abnormal_cardiomyocyte_apopto1.22243464
68MP0003329_amyloid_beta_deposits1.20750193
69MP0004130_abnormal_muscle_cell1.20508609
70MP0005410_abnormal_fertilization1.19841135
71MP0002084_abnormal_developmental_patter1.19417230
72MP0009672_abnormal_birth_weight1.18052733
73MP0000358_abnormal_cell_content/1.17181994
74MP0002697_abnormal_eye_size1.16918924
75MP0004197_abnormal_fetal_growth/weight/1.16793027
76MP0000678_abnormal_parathyroid_gland1.13546341
77MP0005666_abnormal_adipose_tissue1.12562919
78MP0002118_abnormal_lipid_homeostasis1.12493617
79MP0002086_abnormal_extraembryonic_tissu1.11416296
80MP0002085_abnormal_embryonic_tissue1.08747092
81MP0010030_abnormal_orbit_morphology1.08300879
82MP0008775_abnormal_heart_ventricle1.08173212
83MP0003137_abnormal_impulse_conducting1.07952081
84MP0003136_yellow_coat_color1.07388090
85MP0002111_abnormal_tail_morphology1.06406269
86MP0002877_abnormal_melanocyte_morpholog1.04916220
87MP0000749_muscle_degeneration1.02508858
88MP0003119_abnormal_digestive_system1.02256285
89MP0001849_ear_inflammation1.01521215
90MP0000003_abnormal_adipose_tissue1.00415402
91MP0010307_abnormal_tumor_latency1.00018363
92MP0003283_abnormal_digestive_organ0.99007648
93MP0000371_diluted_coat_color0.98984105
94MP0003123_paternal_imprinting0.98823223
95MP0000598_abnormal_liver_morphology0.97212929
96MP0003656_abnormal_erythrocyte_physiolo0.97146337
97MP0003191_abnormal_cellular_cholesterol0.96479414
98MP0005171_absent_coat_pigmentation0.96397554
99MP0003567_abnormal_fetal_cardiomyocyte0.95920883
100MP0004145_abnormal_muscle_electrophysio0.95885680
101MP0001666_abnormal_nutrient_absorption0.95724329
102MP0000750_abnormal_muscle_regeneration0.94676516
103MP0008260_abnormal_autophagy0.93776023
104MP0008770_decreased_survivor_rate0.93433077
105MP0000566_synostosis0.93146380
106MP0005584_abnormal_enzyme/coenzyme_acti0.92841147
107MP0008932_abnormal_embryonic_tissue0.91957363
108MP0003937_abnormal_limbs/digits/tail_de0.90506728
109MP0002106_abnormal_muscle_physiology0.90370199
110MP0000759_abnormal_skeletal_muscle0.90081750
111MP0002019_abnormal_tumor_incidence0.90041392
112MP0004858_abnormal_nervous_system0.89498330
113MP0002075_abnormal_coat/hair_pigmentati0.87618814
114MP0001270_distended_abdomen0.86487037
115MP0003861_abnormal_nervous_system0.86298710
116MP0005220_abnormal_exocrine_pancreas0.86163632
117MP0008961_abnormal_basal_metabolism0.85814123
118MP0005621_abnormal_cell_physiology0.85504163
119MP0005501_abnormal_skin_physiology0.84625835
120MP0002254_reproductive_system_inflammat0.84479156
121MP0002127_abnormal_cardiovascular_syste0.84135855
122MP0002970_abnormal_white_adipose0.82486355
123MP0005384_cellular_phenotype0.81141851
124MP0000049_abnormal_middle_ear0.80484982
125MP0001764_abnormal_homeostasis0.80158991
126MP0003186_abnormal_redox_activity0.78376581
127MP0005385_cardiovascular_system_phenoty0.78116335
128MP0001544_abnormal_cardiovascular_syste0.78116335
129MP0000015_abnormal_ear_pigmentation0.77300643
130MP0000733_abnormal_muscle_development0.76341330
131MP0001545_abnormal_hematopoietic_system0.76083929
132MP0005397_hematopoietic_system_phenotyp0.76083929
133MP0001348_abnormal_lacrimal_gland0.75977251
134MP0008872_abnormal_physiological_respon0.75483371
135MP0000313_abnormal_cell_death0.74863161
136MP0005076_abnormal_cell_differentiation0.74199726
137MP0000266_abnormal_heart_morphology0.73797305
138MP0002332_abnormal_exercise_endurance0.73729050
139MP0002092_abnormal_eye_morphology0.72813616
140MP0003942_abnormal_urinary_system0.72198216
141MP0003115_abnormal_respiratory_system0.71997592
142MP0003943_abnormal_hepatobiliary_system0.71461161
143MP0000428_abnormal_craniofacial_morphol0.70118773
144MP0009697_abnormal_copulation0.69539880
145MP0001293_anophthalmia0.69044292
146MP0003699_abnormal_female_reproductive0.68746501
147MP0004185_abnormal_adipocyte_glucose0.68577612
148MP0002822_catalepsy0.68099149
149MP0001929_abnormal_gametogenesis0.67863517
150MP0003935_abnormal_craniofacial_develop0.67355386
151MP0000703_abnormal_thymus_morphology0.66779461
152MP0006138_congestive_heart_failure0.66338353
153MP0005376_homeostasis/metabolism_phenot0.65590484
154MP0005375_adipose_tissue_phenotype0.65571311
155MP0004264_abnormal_extraembryonic_tissu0.65250877
156MP0003959_abnormal_lean_body0.63821741
157MP0002938_white_spotting0.62244016
158MP0003385_abnormal_body_wall0.61915774
159MP0000477_abnormal_intestine_morphology0.61748291
160MP0005197_abnormal_uvea_morphology0.61607087
161MP0000372_irregular_coat_pigmentation0.61566494

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.63845378
2Abnormality of the lower motor neuron (HP:0002366)4.15554043
3Chromsome breakage (HP:0040012)4.11423728
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.07957296
5Deep venous thrombosis (HP:0002625)4.03058137
6Hyperammonemia (HP:0001987)3.83555908
7Ependymoma (HP:0002888)3.76250100
8Intrahepatic cholestasis (HP:0001406)3.68877763
9Abnormality of pyrimidine metabolism (HP:0004353)3.58067774
10Hypobetalipoproteinemia (HP:0003563)3.56803496
11Birth length less than 3rd percentile (HP:0003561)3.56486277
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.54001160
13Myoglobinuria (HP:0002913)3.49145130
14High anterior hairline (HP:0009890)3.45011237
15Ketosis (HP:0001946)3.37068600
16Hyperglycinuria (HP:0003108)3.32940728
17Xanthomatosis (HP:0000991)3.32285522
18Microvesicular hepatic steatosis (HP:0001414)3.24381969
19Rhabdomyolysis (HP:0003201)3.16921403
20Abnormality of glycine metabolism (HP:0010895)3.07304580
21Abnormality of serine family amino acid metabolism (HP:0010894)3.07304580
22Spastic diplegia (HP:0001264)2.98475242
23Abnormal number of erythroid precursors (HP:0012131)2.97462593
24Hypoglycemic coma (HP:0001325)2.97015381
25Breast hypoplasia (HP:0003187)2.96283369
26Exercise-induced muscle cramps (HP:0003710)2.92323804
27Ragged-red muscle fibers (HP:0003200)2.89293375
28Hyperglycinemia (HP:0002154)2.87941552
29Patellar aplasia (HP:0006443)2.87382320
30Multiple enchondromatosis (HP:0005701)2.85362114
31Reticulocytosis (HP:0001923)2.72472448
32Reticulocytopenia (HP:0001896)2.71827314
33Progressive muscle weakness (HP:0003323)2.70026325
34Cortical dysplasia (HP:0002539)2.67522451
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.67186384
36Abnormality of the Achilles tendon (HP:0005109)2.66325824
37Broad distal phalanx of finger (HP:0009836)2.65354597
38Testicular atrophy (HP:0000029)2.63679104
39Ketoacidosis (HP:0001993)2.62866641
40Aplasia/Hypoplasia of the patella (HP:0006498)2.62406832
41Hypolipoproteinemia (HP:0010981)2.61420529
42Angiofibromas (HP:0010615)2.61322413
43Adenoma sebaceum (HP:0009720)2.61322413
44Partial agenesis of the corpus callosum (HP:0001338)2.58677557
45Pseudobulbar signs (HP:0002200)2.57958373
46Abnormality of cells of the erythroid lineage (HP:0012130)2.57165174
47Hyperlipoproteinemia (HP:0010980)2.57000748
48Meckel diverticulum (HP:0002245)2.56847546
49Sudden death (HP:0001699)2.56324572
50Abnormality of the ileum (HP:0001549)2.55706444
51Abnormality of sulfur amino acid metabolism (HP:0004339)2.49866646
52EMG: neuropathic changes (HP:0003445)2.49409810
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49258283
54Dicarboxylic aciduria (HP:0003215)2.49258283
55Squamous cell carcinoma (HP:0002860)2.47710070
56Exercise-induced myalgia (HP:0003738)2.47595909
57Abnormality of the preputium (HP:0100587)2.44403899
58Cholecystitis (HP:0001082)2.42724801
59Abnormal gallbladder physiology (HP:0012438)2.42724801
60Cholelithiasis (HP:0001081)2.41512919
61Abnormality of the carotid arteries (HP:0005344)2.40618134
62Delayed CNS myelination (HP:0002188)2.36489657
63Astrocytoma (HP:0009592)2.36459846
64Abnormality of the astrocytes (HP:0100707)2.36459846
65Achilles tendon contracture (HP:0001771)2.36129956
66Short thumb (HP:0009778)2.32476881
67Difficulty climbing stairs (HP:0003551)2.32445908
68Ectopic kidney (HP:0000086)2.31156521
69Gout (HP:0001997)2.30564181
70Cerebellar dysplasia (HP:0007033)2.29197233
71Abnormality of reticulocytes (HP:0004312)2.28720368
72Hyporeflexia of lower limbs (HP:0002600)2.27291641
73Abnormality of fatty-acid metabolism (HP:0004359)2.26992700
74High pitched voice (HP:0001620)2.25803353
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21040418
76Hypoalphalipoproteinemia (HP:0003233)2.19510464
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.18897711
78Trigonocephaly (HP:0000243)2.15454357
79Abnormality of chromosome stability (HP:0003220)2.13328105
80Absent epiphyses (HP:0010577)2.13035935
81Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.13035935
82Horseshoe kidney (HP:0000085)2.11501926
83Neonatal onset (HP:0003623)2.10827850
84Long eyelashes (HP:0000527)2.09293303
85Hypopigmentation of the fundus (HP:0007894)2.07394284
86Abnormal gallbladder morphology (HP:0012437)2.07277082
87Dysmetric saccades (HP:0000641)2.06513135
88Ventricular tachycardia (HP:0004756)2.06156835
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05621620
90Upper limb amyotrophy (HP:0009129)2.05321429
91Distal upper limb amyotrophy (HP:0007149)2.05321429
92Cerebral edema (HP:0002181)2.04309433
9311 pairs of ribs (HP:0000878)2.04088836
94Duplicated collecting system (HP:0000081)2.02946902
95Impulsivity (HP:0100710)2.02245514
96Abnormality of the fingertips (HP:0001211)2.01355553
97Abnormality of nucleobase metabolism (HP:0010932)2.01084762
98Abnormality of DNA repair (HP:0003254)1.99770433
99Hyperacusis (HP:0010780)1.99533142
100Abnormal cartilage morphology (HP:0002763)1.99061512
101Selective tooth agenesis (HP:0001592)1.98110699
102Septate vagina (HP:0001153)1.97836804
103Neoplasm of striated muscle (HP:0009728)1.97775831
104Abnormality of methionine metabolism (HP:0010901)1.97576409
105Duodenal stenosis (HP:0100867)1.96062858
106Small intestinal stenosis (HP:0012848)1.96062858
107Ulnar bowing (HP:0003031)1.95899125
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.95046382
109Nonimmune hydrops fetalis (HP:0001790)1.94848335
110Global brain atrophy (HP:0002283)1.94531116
111Premature skin wrinkling (HP:0100678)1.92318067
112Bundle branch block (HP:0011710)1.91754530
113Atrioventricular block (HP:0001678)1.89740012
114Abnormality of serum amino acid levels (HP:0003112)1.89425544
115Abnormality of the motor neurons (HP:0002450)1.89425072
116Abnormal neuron morphology (HP:0012757)1.89425072
117Basal cell carcinoma (HP:0002671)1.89180039
118Oral leukoplakia (HP:0002745)1.88642959
119Difficulty running (HP:0009046)1.87901251
120Lethargy (HP:0001254)1.87334860
121Absent radius (HP:0003974)1.86788681
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85982619
123Ureteral duplication (HP:0000073)1.85614015
124Hypercholesterolemia (HP:0003124)1.85067218
125Renovascular hypertension (HP:0100817)1.84852275
126Self-mutilation (HP:0000742)1.84016976
127Increased connective tissue (HP:0009025)1.83676845
128Entropion (HP:0000621)1.83037914
129Hand muscle atrophy (HP:0009130)1.82939034
130Fibroma (HP:0010614)1.82905047
131Pointed chin (HP:0000307)1.82867454
132Skull defect (HP:0001362)1.82033145
133Acute lymphatic leukemia (HP:0006721)1.81622187
134Asymmetric septal hypertrophy (HP:0001670)1.80864648
135Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80458031
136Absent thumb (HP:0009777)1.79899858
137Palpitations (HP:0001962)1.79601660
138Hyperbilirubinemia (HP:0002904)1.78467988
139Duplication of thumb phalanx (HP:0009942)1.78326132
140Status epilepticus (HP:0002133)1.78306276
141Stridor (HP:0010307)1.77755704
142Back pain (HP:0003418)1.77312789
143Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77166049
144Hyperinsulinemic hypoglycemia (HP:0000825)1.76818449
145Aplasia involving forearm bones (HP:0009822)1.76732996
146Absent forearm bone (HP:0003953)1.76732996
147Amyotrophic lateral sclerosis (HP:0007354)1.76563926
148Late onset (HP:0003584)1.76552159
149Rhabdomyosarcoma (HP:0002859)1.76390142
150Abnormality of the phalanges of the hallux (HP:0010057)1.75968478
151Muscle stiffness (HP:0003552)1.75909029
152Fibrous tissue neoplasm (HP:0012316)1.75707914
153Cerebral hypomyelination (HP:0006808)1.75616754
154Microretrognathia (HP:0000308)1.75369016
155Short 5th finger (HP:0009237)1.75029278
156Cafe-au-lait spot (HP:0000957)1.74533740
157Long palpebral fissure (HP:0000637)1.74064003
158Morphological abnormality of the inner ear (HP:0011390)1.73341069
159Complement deficiency (HP:0004431)1.72932586
160Increased nuchal translucency (HP:0010880)1.72828846
161Insomnia (HP:0100785)1.72329571
162Neoplasm of the oral cavity (HP:0100649)1.72286630
163Abnormality of the calcaneus (HP:0008364)1.72165068
164Deviation of the thumb (HP:0009603)1.72081848
165Proximal placement of thumb (HP:0009623)1.71844403
166Disproportionate tall stature (HP:0001519)1.71834933
167Lymphangioma (HP:0100764)1.71327291
168Abnormality of the salivary glands (HP:0010286)1.70778555
169Brushfield spots (HP:0001088)1.70564364
170Elfin facies (HP:0004428)1.70451551
171Metabolic acidosis (HP:0001942)1.70393875
172Deep palmar crease (HP:0006191)1.70132544
173Abnormality of homocysteine metabolism (HP:0010919)1.69618135
174Homocystinuria (HP:0002156)1.69618135
175Rectal prolapse (HP:0002035)1.69085685
176Abnormality of the thoracic spine (HP:0100711)1.66411565
177Increased neuronal autofluorescent lipopigment (HP:0002074)1.65914054
178Sloping forehead (HP:0000340)1.65482632
179Abnormal number of incisors (HP:0011064)1.65446967
180Patellar dislocation (HP:0002999)1.65117137
181Sandal gap (HP:0001852)1.64492298
182Missing ribs (HP:0000921)1.64242053
183Preauricular skin tag (HP:0000384)1.64113688
184Poikiloderma (HP:0001029)1.63861134
185Optic nerve coloboma (HP:0000588)1.62079740
186Anal stenosis (HP:0002025)1.61269137

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.82885470
2SMG13.64465980
3BCKDK3.36563659
4TRIB33.13926172
5NEK13.01108993
6SRPK12.89032594
7EEF2K2.79190013
8BUB12.58352475
9ICK2.42858657
10NME22.42711376
11PDK32.39360981
12PDK42.39360981
13CDC72.36016285
14MAP3K102.32620683
15CDK122.25458846
16PBK2.19158521
17ZAK2.06212179
18NEK22.04738545
19TTN1.98946642
20IRAK31.90724625
21CAMK1D1.87401265
22CHEK21.86732431
23FLT31.82375801
24WEE11.81790434
25MAP3K111.79958391
26PIM21.70806135
27RPS6KB21.58478621
28EPHA21.48389014
29TSSK61.44343100
30PRKD31.41667425
31WNK41.36543798
32MAP2K31.33669724
33NME11.32129616
34TTK1.30905501
35ALK1.30242534
36TESK21.23792368
37MAP3K81.21351370
38ERN11.21304352
39TLK11.19204807
40GRK61.16790610
41SIK21.15985211
42LRRK21.12980136
43SCYL21.11578678
44MTOR1.11541673
45CDK41.09873942
46PTK61.08538664
47TYRO31.06224443
48CAMK1G1.05109961
49MAPKAPK31.03483828
50TAOK11.02677877
51DYRK31.00450882
52SIK10.99420970
53RPS6KA50.95376587
54PLK40.94918673
55RIPK10.94493891
56PRPF4B0.94047801
57PHKG10.91512244
58PHKG20.91512244
59PDK20.90642354
60PAK40.90285607
61RAF10.89890603
62INSRR0.88394614
63VRK20.88379951
64PRKCI0.88291214
65CDK70.88275969
66PDGFRA0.87091766
67LATS20.87041995
68PLK10.85084901
69ATR0.83432702
70MAP4K10.81929519
71AKT20.80994466
72CHEK10.79965842
73DAPK10.79208014
74MAP3K70.79106560
75MAPK110.78889100
76STK100.77319100
77ATM0.76295047
78RPS6KA20.76109979
79MAP3K90.76068448
80PAK60.74548872
81LMTK20.72886778
82DAPK30.72144383
83AURKA0.71300359
84CDK80.70648171
85FGFR40.67609777
86KDR0.65306635
87* CDK20.64325824
88KSR20.63650637
89MAPKAPK50.61210564
90PIM10.61040585
91TGFBR10.60726588
92PASK0.60417116
93AURKB0.59539117
94CLK10.59006394
95PAK20.57278894
96TAOK20.56698160
97MAP2K20.56486524
98CSNK1E0.55902898
99TESK10.53524888
100PNCK0.53518307
101ACVR1B0.52874884
102FGFR10.51964907
103DAPK20.51758871
104PINK10.51445392
105RPS6KL10.51345547
106RPS6KC10.51345547
107STK160.50855354
108BRD40.50349615
109RPS6KA40.49852613
110MKNK10.49552751
111PRKD20.49532991
112MAP2K60.49336202
113RPS6KA10.49195834
114CDK90.48766882
115STK380.48750118
116BRAF0.48458000
117CAMKK10.47876277
118BRSK10.47435872
119MST1R0.46100316
120CSNK2A20.46098520
121CSNK1G30.46054377
122BMX0.44967282
123LATS10.44310883
124MARK20.44277450
125STK40.44165094
126UHMK10.43959663
127VRK10.43270231
128RPS6KA60.43196330
129MAPK120.41939470
130PAK10.41384081
131NTRK10.40838825
132CSNK1A1L0.40668506
133PRKAA10.38672516
134GSK3B0.38617681
135PRKDC0.38453004
136CAMK40.36410032
137MAPK140.34946859
138CDK10.34865949
139DYRK1B0.34626892
140MAP2K40.33998440
141AKT10.33278901
142CSNK1G10.27815350

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.88980392
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.50400710
3Nitrogen metabolism_Homo sapiens_hsa009103.32758615
4Non-homologous end-joining_Homo sapiens_hsa034503.07551886
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.79715306
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.74050783
7Arginine biosynthesis_Homo sapiens_hsa002202.73565870
8Biosynthesis of amino acids_Homo sapiens_hsa012302.67223036
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.54813553
10Carbon metabolism_Homo sapiens_hsa012002.39007445
11Fanconi anemia pathway_Homo sapiens_hsa034602.38358685
12DNA replication_Homo sapiens_hsa030302.34816209
13Fatty acid degradation_Homo sapiens_hsa000712.26937632
14One carbon pool by folate_Homo sapiens_hsa006702.15980238
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.14569694
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10842553
17Propanoate metabolism_Homo sapiens_hsa006402.08523871
18Sulfur relay system_Homo sapiens_hsa041221.99001421
19Pyruvate metabolism_Homo sapiens_hsa006201.97650180
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.96036252
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.93901571
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.89606900
23Selenocompound metabolism_Homo sapiens_hsa004501.84561870
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.81546419
25RNA polymerase_Homo sapiens_hsa030201.78784268
26Tryptophan metabolism_Homo sapiens_hsa003801.72147232
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.70300356
28Mismatch repair_Homo sapiens_hsa034301.68414382
29Fatty acid metabolism_Homo sapiens_hsa012121.62732728
30* Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56400353
31Butanoate metabolism_Homo sapiens_hsa006501.52089991
32Pentose phosphate pathway_Homo sapiens_hsa000301.50190207
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.41653543
34N-Glycan biosynthesis_Homo sapiens_hsa005101.34885269
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29852942
36RNA transport_Homo sapiens_hsa030131.28946991
37Base excision repair_Homo sapiens_hsa034101.28038166
38Spliceosome_Homo sapiens_hsa030401.25930816
39Lysine degradation_Homo sapiens_hsa003101.25791353
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22402834
41PPAR signaling pathway_Homo sapiens_hsa033201.21452940
42Alcoholism_Homo sapiens_hsa050341.14107515
43Folate biosynthesis_Homo sapiens_hsa007901.14038573
44Bile secretion_Homo sapiens_hsa049761.13403635
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12380716
46Fructose and mannose metabolism_Homo sapiens_hsa000511.07870531
47Peroxisome_Homo sapiens_hsa041461.07063226
48Steroid biosynthesis_Homo sapiens_hsa001001.06489715
49Arginine and proline metabolism_Homo sapiens_hsa003301.05886874
50Viral carcinogenesis_Homo sapiens_hsa052031.05796039
51Other glycan degradation_Homo sapiens_hsa005111.03005744
52beta-Alanine metabolism_Homo sapiens_hsa004101.01590375
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01019664
54Phenylalanine metabolism_Homo sapiens_hsa003600.99386084
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.94651840
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93294072
57Purine metabolism_Homo sapiens_hsa002300.91121201
58Fatty acid biosynthesis_Homo sapiens_hsa000610.90605311
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90547788
60Ribosome_Homo sapiens_hsa030100.89417269
61Galactose metabolism_Homo sapiens_hsa000520.83658717
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81625914
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79994868
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78632310
65Complement and coagulation cascades_Homo sapiens_hsa046100.78081548
66Glucagon signaling pathway_Homo sapiens_hsa049220.77876825
67Fat digestion and absorption_Homo sapiens_hsa049750.77027919
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69678749
69Non-small cell lung cancer_Homo sapiens_hsa052230.69131157
70Cardiac muscle contraction_Homo sapiens_hsa042600.68695491
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67789325
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67627815
73MicroRNAs in cancer_Homo sapiens_hsa052060.67560680
74Basal cell carcinoma_Homo sapiens_hsa052170.67304610
75Vitamin digestion and absorption_Homo sapiens_hsa049770.66022781
76mRNA surveillance pathway_Homo sapiens_hsa030150.65856264
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64614982
78Basal transcription factors_Homo sapiens_hsa030220.64545842
79ABC transporters_Homo sapiens_hsa020100.63236177
80Acute myeloid leukemia_Homo sapiens_hsa052210.62615236
81Glycerolipid metabolism_Homo sapiens_hsa005610.62589623
82Chemical carcinogenesis_Homo sapiens_hsa052040.62588989
83Chronic myeloid leukemia_Homo sapiens_hsa052200.61409371
84Nucleotide excision repair_Homo sapiens_hsa034200.60284110
85Primary immunodeficiency_Homo sapiens_hsa053400.60209498
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60197319
87Small cell lung cancer_Homo sapiens_hsa052220.59775791
88Tyrosine metabolism_Homo sapiens_hsa003500.59645234
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58575171
90Vitamin B6 metabolism_Homo sapiens_hsa007500.57908476
91Pyrimidine metabolism_Homo sapiens_hsa002400.57492640
92Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57490505
93p53 signaling pathway_Homo sapiens_hsa041150.57137290
94Starch and sucrose metabolism_Homo sapiens_hsa005000.56759529
95AMPK signaling pathway_Homo sapiens_hsa041520.53560837
96Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53483762
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51031121
98Insulin resistance_Homo sapiens_hsa049310.49897861
99Systemic lupus erythematosus_Homo sapiens_hsa053220.48708345
100Glutathione metabolism_Homo sapiens_hsa004800.48182188
101Caffeine metabolism_Homo sapiens_hsa002320.47087117
102mTOR signaling pathway_Homo sapiens_hsa041500.46534264
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44332046
104Insulin signaling pathway_Homo sapiens_hsa049100.44186432
105Epstein-Barr virus infection_Homo sapiens_hsa051690.44104415
106Glycosaminoglycan degradation_Homo sapiens_hsa005310.43213143
107Cell cycle_Homo sapiens_hsa041100.40288438
108Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40156065
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.38982904
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38397976
111Hippo signaling pathway_Homo sapiens_hsa043900.38299795
112Apoptosis_Homo sapiens_hsa042100.37701552
113HTLV-I infection_Homo sapiens_hsa051660.36625280
114Metabolic pathways_Homo sapiens_hsa011000.35874850
115Histidine metabolism_Homo sapiens_hsa003400.35346179
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32260087
117Proteasome_Homo sapiens_hsa030500.31808653
118Prostate cancer_Homo sapiens_hsa052150.31573615
119Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29965533
120Fatty acid elongation_Homo sapiens_hsa000620.29359873
121Hepatitis B_Homo sapiens_hsa051610.29030432
122Retinol metabolism_Homo sapiens_hsa008300.29003571
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28463302
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27721512
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27335329
126Bladder cancer_Homo sapiens_hsa052190.27290309
127Hedgehog signaling pathway_Homo sapiens_hsa043400.27169359
128Colorectal cancer_Homo sapiens_hsa052100.26804049
129VEGF signaling pathway_Homo sapiens_hsa043700.26626442
130Oocyte meiosis_Homo sapiens_hsa041140.26246612
131RNA degradation_Homo sapiens_hsa030180.25388869
132Parkinsons disease_Homo sapiens_hsa050120.24869697
133Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24642339
134Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22402618
135Huntingtons disease_Homo sapiens_hsa050160.22244927
136Inositol phosphate metabolism_Homo sapiens_hsa005620.21542012
137Melanoma_Homo sapiens_hsa052180.21433245
138Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19668107
139Homologous recombination_Homo sapiens_hsa034400.18478947
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17522545
141Thyroid cancer_Homo sapiens_hsa052160.16756155
142Notch signaling pathway_Homo sapiens_hsa043300.16442722
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.15229338
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.14568654
145Prion diseases_Homo sapiens_hsa050200.14521686

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