

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA strand elongation involved in DNA replication (GO:0006271) | 5.30975110 |
| 2 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.23141194 |
| 3 | telomere maintenance via semi-conservative replication (GO:0032201) | 5.11460463 |
| 4 | DNA strand elongation (GO:0022616) | 5.08812619 |
| 5 | DNA deamination (GO:0045006) | 5.02926811 |
| 6 | DNA replication initiation (GO:0006270) | 4.91670423 |
| 7 | chaperone-mediated protein transport (GO:0072321) | 4.76351400 |
| 8 | nucleobase biosynthetic process (GO:0046112) | 4.70995054 |
| 9 | purine nucleobase biosynthetic process (GO:0009113) | 4.47572844 |
| 10 | DNA unwinding involved in DNA replication (GO:0006268) | 4.39691653 |
| 11 | telomere maintenance via recombination (GO:0000722) | 4.37711430 |
| 12 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.37360695 |
| 13 | DNA replication checkpoint (GO:0000076) | 4.17289424 |
| 14 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 4.12750179 |
| 15 | cullin deneddylation (GO:0010388) | 4.10574726 |
| 16 | mitotic recombination (GO:0006312) | 4.09880706 |
| 17 | ribosomal small subunit assembly (GO:0000028) | 3.98850203 |
| 18 | protein deneddylation (GO:0000338) | 3.91761949 |
| 19 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.90624028 |
| 20 | telomere maintenance via telomere lengthening (GO:0010833) | 3.90074529 |
| 21 | respiratory electron transport chain (GO:0022904) | 3.88279760 |
| 22 | IMP biosynthetic process (GO:0006188) | 3.88024193 |
| 23 | formation of translation preinitiation complex (GO:0001731) | 3.85662099 |
| 24 | electron transport chain (GO:0022900) | 3.82603215 |
| 25 | respiratory chain complex IV assembly (GO:0008535) | 3.79536629 |
| 26 | proteasome assembly (GO:0043248) | 3.78893681 |
| 27 | ribosome biogenesis (GO:0042254) | 3.74448531 |
| 28 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.70194950 |
| 29 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.69284094 |
| 30 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.67883082 |
| 31 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.67446503 |
| 32 | pseudouridine synthesis (GO:0001522) | 3.66200563 |
| 33 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.64633469 |
| 34 | negative regulation of ligase activity (GO:0051352) | 3.58219636 |
| 35 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.58219636 |
| 36 | maturation of SSU-rRNA (GO:0030490) | 3.58091044 |
| 37 | spliceosomal snRNP assembly (GO:0000387) | 3.56136147 |
| 38 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.48685214 |
| 39 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.47903572 |
| 40 | establishment of integrated proviral latency (GO:0075713) | 3.47243107 |
| 41 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.45610120 |
| 42 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.45610120 |
| 43 | protein targeting to mitochondrion (GO:0006626) | 3.45139843 |
| 44 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.43425352 |
| 45 | cytochrome complex assembly (GO:0017004) | 3.43348498 |
| 46 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.42765397 |
| 47 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.42765397 |
| 48 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.42668714 |
| 49 | ATP synthesis coupled proton transport (GO:0015986) | 3.42668714 |
| 50 | behavioral response to nicotine (GO:0035095) | 3.41002814 |
| 51 | CENP-A containing nucleosome assembly (GO:0034080) | 3.40549863 |
| 52 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.40398367 |
| 53 | peptidyl-histidine modification (GO:0018202) | 3.40054152 |
| 54 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.39149604 |
| 55 | chromatin remodeling at centromere (GO:0031055) | 3.36276003 |
| 56 | protein localization to kinetochore (GO:0034501) | 3.36091617 |
| 57 | regulation of mitochondrial translation (GO:0070129) | 3.35124052 |
| 58 | establishment of protein localization to mitochondrion (GO:0072655) | 3.32777431 |
| 59 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.32544967 |
| 60 | IMP metabolic process (GO:0046040) | 3.31375002 |
| 61 | viral mRNA export from host cell nucleus (GO:0046784) | 3.30613492 |
| 62 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.30400359 |
| 63 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.30303962 |
| 64 | protein-cofactor linkage (GO:0018065) | 3.29304634 |
| 65 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.28535800 |
| 66 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.28535800 |
| 67 | rRNA processing (GO:0006364) | 3.28180199 |
| 68 | oxidative phosphorylation (GO:0006119) | 3.27462404 |
| 69 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.27044790 |
| 70 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.27044790 |
| 71 | NADH dehydrogenase complex assembly (GO:0010257) | 3.27044790 |
| 72 | protein localization to mitochondrion (GO:0070585) | 3.26617862 |
| 73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.26202315 |
| 74 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.26202315 |
| 75 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.26202315 |
| 76 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.24966172 |
| 77 | cell cycle G1/S phase transition (GO:0044843) | 3.24966172 |
| 78 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.23457239 |
| 79 | termination of RNA polymerase III transcription (GO:0006386) | 3.23457239 |
| 80 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.20799846 |
| 81 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.20799846 |
| 82 | protein neddylation (GO:0045116) | 3.20704813 |
| 83 | synapsis (GO:0007129) | 3.19915100 |
| 84 | mitotic metaphase plate congression (GO:0007080) | 3.19786315 |
| 85 | rRNA modification (GO:0000154) | 3.18081988 |
| 86 | histone H2A acetylation (GO:0043968) | 3.16576694 |
| 87 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.16531940 |
| 88 | DNA replication-independent nucleosome organization (GO:0034724) | 3.16343920 |
| 89 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.16343920 |
| 90 | rRNA metabolic process (GO:0016072) | 3.14442921 |
| 91 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.12777432 |
| 92 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.12777432 |
| 93 | mitochondrial respiratory chain complex assembly (GO:0033108) | 3.12099801 |
| 94 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.12065314 |
| 95 | cellular component biogenesis (GO:0044085) | 3.12016905 |
| 96 | spliceosomal complex assembly (GO:0000245) | 3.11786407 |
| 97 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.11738159 |
| 98 | viral transcription (GO:0019083) | 3.11713617 |
| 99 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.11024330 |
| 100 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.10843684 |
| 101 | translational elongation (GO:0006414) | 3.09146411 |
| 102 | ribosomal small subunit biogenesis (GO:0042274) | 3.07703448 |
| 103 | ubiquinone biosynthetic process (GO:0006744) | 3.07700628 |
| 104 | translational termination (GO:0006415) | 3.07477119 |
| 105 | maturation of 5.8S rRNA (GO:0000460) | 3.06966980 |
| 106 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.06030221 |
| 107 | mitotic sister chromatid segregation (GO:0000070) | 3.05444385 |
| 108 | protein complex biogenesis (GO:0070271) | 3.04672004 |
| 109 | somatic diversification of immune receptors via somatic mutation (GO:0002566) | 3.04495252 |
| 110 | somatic hypermutation of immunoglobulin genes (GO:0016446) | 3.04495252 |
| 111 | * amino acid activation (GO:0043038) | 3.04225461 |
| 112 | * tRNA aminoacylation (GO:0043039) | 3.04225461 |
| 113 | * tRNA aminoacylation for protein translation (GO:0006418) | 3.04014625 |
| 114 | iron-sulfur cluster assembly (GO:0016226) | 3.03079566 |
| 115 | metallo-sulfur cluster assembly (GO:0031163) | 3.03079566 |
| 116 | 7-methylguanosine mRNA capping (GO:0006370) | 3.00501952 |
| 117 | ribosome assembly (GO:0042255) | 3.00163496 |
| 118 | positive regulation of ligase activity (GO:0051351) | 2.99138089 |
| 119 | DNA damage response, detection of DNA damage (GO:0042769) | 2.98143149 |
| 120 | 7-methylguanosine RNA capping (GO:0009452) | 2.97712623 |
| 121 | DNA double-strand break processing (GO:0000729) | 2.96760232 |
| 122 | ribosomal large subunit biogenesis (GO:0042273) | 2.93675677 |
| 123 | positive regulation of mitochondrial fission (GO:0090141) | 2.92842619 |
| 124 | intracellular protein transmembrane import (GO:0044743) | 2.91794546 |
| 125 | ubiquinone metabolic process (GO:0006743) | 2.91752558 |
| 126 | inner mitochondrial membrane organization (GO:0007007) | 2.91684311 |
| 127 | replication fork processing (GO:0031297) | 2.89399321 |
| 128 | tRNA processing (GO:0008033) | 2.88581607 |
| 129 | rRNA methylation (GO:0031167) | 2.85921295 |
| 130 | preassembly of GPI anchor in ER membrane (GO:0016254) | 2.81362000 |
| 131 | resolution of meiotic recombination intermediates (GO:0000712) | 2.80592196 |
| 132 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 2.79571002 |
| 133 | ATP biosynthetic process (GO:0006754) | 2.79274052 |
| 134 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.78139747 |
| 135 | * tRNA metabolic process (GO:0006399) | 2.75271830 |
| 136 | GTP biosynthetic process (GO:0006183) | 2.74547781 |
| 137 | protein polyglutamylation (GO:0018095) | 2.73323508 |
| 138 | translation (GO:0006412) | 2.71188360 |
| 139 | base-excision repair, AP site formation (GO:0006285) | 2.67621761 |
| 140 | histone exchange (GO:0043486) | 2.66534601 |
| 141 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.65199410 |
| 142 | hydrogen ion transmembrane transport (GO:1902600) | 2.64997347 |
| 143 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.63867927 |
| 144 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.63343328 |
| 145 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.63343328 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 7.83161746 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.43282265 |
| 3 | * EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.41311104 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.01321543 |
| 5 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.64470235 |
| 6 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.58484226 |
| 7 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 3.42745647 |
| 8 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.42025732 |
| 9 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.38618196 |
| 10 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.34954423 |
| 11 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.29710305 |
| 12 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.22081324 |
| 13 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.92185628 |
| 14 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.91112465 |
| 15 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.87853933 |
| 16 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.71275880 |
| 17 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.58466584 |
| 18 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.51448752 |
| 19 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.50892674 |
| 20 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.50308299 |
| 21 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.46825746 |
| 22 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.44596791 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.42831950 |
| 24 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.36574174 |
| 25 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.28325321 |
| 26 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.25370326 |
| 27 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.22485991 |
| 28 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.21519336 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.17571620 |
| 30 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.13346378 |
| 31 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.13228066 |
| 32 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.10765937 |
| 33 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.10109607 |
| 34 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.01880023 |
| 35 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.95436446 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.93591575 |
| 37 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.89507011 |
| 38 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.87307632 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.83548935 |
| 40 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.82393547 |
| 41 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.81740244 |
| 42 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.79961860 |
| 43 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.79422769 |
| 44 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.78644318 |
| 45 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.78225999 |
| 46 | VDR_22108803_ChIP-Seq_LS180_Human | 1.70732356 |
| 47 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.68734745 |
| 48 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.67796442 |
| 49 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.67488656 |
| 50 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.62694860 |
| 51 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.61852203 |
| 52 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.61789550 |
| 53 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.60536637 |
| 54 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.58961328 |
| 55 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52431396 |
| 56 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.51041034 |
| 57 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.50184123 |
| 58 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.49644825 |
| 59 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.47894723 |
| 60 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.43685222 |
| 61 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.38436908 |
| 62 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.35038993 |
| 63 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.31341224 |
| 64 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.30970735 |
| 65 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.29822571 |
| 66 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.29624974 |
| 67 | EWS_26573619_Chip-Seq_HEK293_Human | 1.29485996 |
| 68 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.27971248 |
| 69 | FUS_26573619_Chip-Seq_HEK293_Human | 1.24058632 |
| 70 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.21858798 |
| 71 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.20936675 |
| 72 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.15881735 |
| 73 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.13588771 |
| 74 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.12496128 |
| 75 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.12492026 |
| 76 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12144354 |
| 77 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.12109066 |
| 78 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.10097390 |
| 79 | * IRF1_19129219_ChIP-ChIP_H3396_Human | 1.09711813 |
| 80 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 1.08263063 |
| 81 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.07740341 |
| 82 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.06189625 |
| 83 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.03389029 |
| 84 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.02012472 |
| 85 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.00841195 |
| 86 | MYC_22102868_ChIP-Seq_BL_Human | 1.00347862 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.98654538 |
| 88 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.98213105 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.97854279 |
| 90 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 0.97000417 |
| 91 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.96896534 |
| 92 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.96862534 |
| 93 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 0.96797010 |
| 94 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.95665762 |
| 95 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.94937469 |
| 96 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.92847012 |
| 97 | * CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.92625697 |
| 98 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.91957602 |
| 99 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.91607356 |
| 100 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.91602688 |
| 101 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.90800491 |
| 102 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.90525341 |
| 103 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 0.90398987 |
| 104 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 0.89897493 |
| 105 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.89776696 |
| 106 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.88634249 |
| 107 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.86901879 |
| 108 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.85924242 |
| 109 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.85521522 |
| 110 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.84096886 |
| 111 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.83876378 |
| 112 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.83768261 |
| 113 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 0.82750342 |
| 114 | NCOR_22424771_ChIP-Seq_293T_Human | 0.80859396 |
| 115 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 0.79726667 |
| 116 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.79273732 |
| 117 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.78987285 |
| 118 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.78757349 |
| 119 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.78465867 |
| 120 | FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.78132223 |
| 121 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.77649952 |
| 122 | EBNA2_21746931_ChIP-Seq_IB4-LCL_Human | 0.77542738 |
| 123 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.77231590 |
| 124 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.75307305 |
| 125 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.74316216 |
| 126 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.73057055 |
| 127 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.73011446 |
| 128 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.72808593 |
| 129 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.72808593 |
| 130 | * TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.70825090 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 4.73328528 |
| 2 | MP0010094_abnormal_chromosome_stability | 4.63574075 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.26921095 |
| 4 | MP0003111_abnormal_nucleus_morphology | 4.09699889 |
| 5 | MP0008057_abnormal_DNA_replication | 3.70535249 |
| 6 | MP0003077_abnormal_cell_cycle | 3.58960032 |
| 7 | MP0008058_abnormal_DNA_repair | 3.40670011 |
| 8 | MP0008932_abnormal_embryonic_tissue | 2.69074099 |
| 9 | MP0001529_abnormal_vocalization | 2.67051906 |
| 10 | MP0008877_abnormal_DNA_methylation | 2.64819612 |
| 11 | MP0003123_paternal_imprinting | 2.55923732 |
| 12 | MP0002837_dystrophic_cardiac_calcinosis | 2.44910291 |
| 13 | MP0006036_abnormal_mitochondrial_physio | 2.40955001 |
| 14 | MP0008007_abnormal_cellular_replicative | 2.38048683 |
| 15 | MP0006035_abnormal_mitochondrial_morpho | 2.26897973 |
| 16 | MP0003806_abnormal_nucleotide_metabolis | 2.25144662 |
| 17 | MP0002102_abnormal_ear_morphology | 2.14092682 |
| 18 | MP0004147_increased_porphyrin_level | 2.08583147 |
| 19 | MP0002822_catalepsy | 1.94871610 |
| 20 | MP0006292_abnormal_olfactory_placode | 1.89662824 |
| 21 | MP0001730_embryonic_growth_arrest | 1.88631283 |
| 22 | MP0009379_abnormal_foot_pigmentation | 1.87354986 |
| 23 | MP0003646_muscle_fatigue | 1.85722744 |
| 24 | MP0002396_abnormal_hematopoietic_system | 1.79268763 |
| 25 | MP0003786_premature_aging | 1.78816538 |
| 26 | MP0000372_irregular_coat_pigmentation | 1.71759670 |
| 27 | MP0004145_abnormal_muscle_electrophysio | 1.70831085 |
| 28 | MP0003880_abnormal_central_pattern | 1.65691570 |
| 29 | MP0000350_abnormal_cell_proliferation | 1.56928333 |
| 30 | MP0003718_maternal_effect | 1.51096230 |
| 31 | MP0003186_abnormal_redox_activity | 1.50782469 |
| 32 | MP0008995_early_reproductive_senescence | 1.50395391 |
| 33 | MP0002653_abnormal_ependyma_morphology | 1.50001800 |
| 34 | MP0001485_abnormal_pinna_reflex | 1.44395624 |
| 35 | MP0003121_genomic_imprinting | 1.42918813 |
| 36 | MP0005551_abnormal_eye_electrophysiolog | 1.42657239 |
| 37 | MP0003656_abnormal_erythrocyte_physiolo | 1.42591937 |
| 38 | MP0005084_abnormal_gallbladder_morpholo | 1.42210470 |
| 39 | MP0001905_abnormal_dopamine_level | 1.41077330 |
| 40 | MP0000358_abnormal_cell_content/ | 1.39517463 |
| 41 | MP0000049_abnormal_middle_ear | 1.35675971 |
| 42 | MP0002736_abnormal_nociception_after | 1.34724197 |
| 43 | MP0002938_white_spotting | 1.32351082 |
| 44 | MP0001968_abnormal_touch/_nociception | 1.27662285 |
| 45 | MP0005075_abnormal_melanosome_morpholog | 1.27416656 |
| 46 | MP0002080_prenatal_lethality | 1.27252801 |
| 47 | MP0002638_abnormal_pupillary_reflex | 1.26635937 |
| 48 | MP0004142_abnormal_muscle_tone | 1.25301298 |
| 49 | MP0005253_abnormal_eye_physiology | 1.25147724 |
| 50 | MP0003011_delayed_dark_adaptation | 1.23166305 |
| 51 | MP0000313_abnormal_cell_death | 1.22678239 |
| 52 | MP0001697_abnormal_embryo_size | 1.19136859 |
| 53 | MP0001764_abnormal_homeostasis | 1.18147955 |
| 54 | MP0006276_abnormal_autonomic_nervous | 1.17784965 |
| 55 | MP0000631_abnormal_neuroendocrine_gland | 1.14504287 |
| 56 | MP0005266_abnormal_metabolism | 1.14350749 |
| 57 | MP0009697_abnormal_copulation | 1.12435893 |
| 58 | MP0001293_anophthalmia | 1.11660919 |
| 59 | MP0008872_abnormal_physiological_respon | 1.08435231 |
| 60 | MP0002132_abnormal_respiratory_system | 1.07444939 |
| 61 | MP0009745_abnormal_behavioral_response | 1.06177587 |
| 62 | MP0000490_abnormal_crypts_of | 1.05372531 |
| 63 | MP0003635_abnormal_synaptic_transmissio | 1.04708119 |
| 64 | MP0002160_abnormal_reproductive_system | 1.03903385 |
| 65 | MP0004133_heterotaxia | 1.03848360 |
| 66 | MP0004859_abnormal_synaptic_plasticity | 1.03827731 |
| 67 | MP0005394_taste/olfaction_phenotype | 1.03244045 |
| 68 | MP0005499_abnormal_olfactory_system | 1.03244045 |
| 69 | MP0003787_abnormal_imprinting | 1.01081996 |
| 70 | MP0002064_seizures | 1.01042614 |
| 71 | MP0001188_hyperpigmentation | 1.01014041 |
| 72 | MP0002019_abnormal_tumor_incidence | 1.00627526 |
| 73 | MP0001984_abnormal_olfaction | 1.00234164 |
| 74 | MP0002272_abnormal_nervous_system | 0.99518875 |
| 75 | MP0003890_abnormal_embryonic-extraembry | 0.96551508 |
| 76 | MP0003698_abnormal_male_reproductive | 0.96322820 |
| 77 | MP0002735_abnormal_chemical_nociception | 0.95127673 |
| 78 | MP0003567_abnormal_fetal_cardiomyocyte | 0.94893566 |
| 79 | MP0006054_spinal_hemorrhage | 0.94290637 |
| 80 | MP0005367_renal/urinary_system_phenotyp | 0.93833121 |
| 81 | MP0000516_abnormal_urinary_system | 0.93833121 |
| 82 | MP0005646_abnormal_pituitary_gland | 0.93539464 |
| 83 | MP0008789_abnormal_olfactory_epithelium | 0.91940765 |
| 84 | MP0001672_abnormal_embryogenesis/_devel | 0.91579647 |
| 85 | MP0005380_embryogenesis_phenotype | 0.91579647 |
| 86 | MP0005645_abnormal_hypothalamus_physiol | 0.90385760 |
| 87 | MP0003119_abnormal_digestive_system | 0.88785956 |
| 88 | MP0002557_abnormal_social/conspecific_i | 0.88140672 |
| 89 | MP0005423_abnormal_somatic_nervous | 0.87642378 |
| 90 | MP0005397_hematopoietic_system_phenotyp | 0.87408584 |
| 91 | MP0001545_abnormal_hematopoietic_system | 0.87408584 |
| 92 | MP0003136_yellow_coat_color | 0.86414125 |
| 93 | MP0002063_abnormal_learning/memory/cond | 0.85692031 |
| 94 | MP0000778_abnormal_nervous_system | 0.85205416 |
| 95 | MP0002085_abnormal_embryonic_tissue | 0.84789493 |
| 96 | MP0002752_abnormal_somatic_nervous | 0.83512816 |
| 97 | MP0003122_maternal_imprinting | 0.83351758 |
| 98 | MP0003937_abnormal_limbs/digits/tail_de | 0.83265677 |
| 99 | MP0008260_abnormal_autophagy | 0.82720645 |
| 100 | MP0002210_abnormal_sex_determination | 0.82411632 |
| 101 | MP0004811_abnormal_neuron_physiology | 0.82231625 |
| 102 | MP0002734_abnormal_mechanical_nocicepti | 0.82200672 |
| 103 | MP0005410_abnormal_fertilization | 0.81419066 |
| 104 | MP0002067_abnormal_sensory_capabilities | 0.80907046 |
| 105 | MP0002184_abnormal_innervation | 0.80898243 |
| 106 | MP0000015_abnormal_ear_pigmentation | 0.80522560 |
| 107 | MP0002572_abnormal_emotion/affect_behav | 0.80426137 |
| 108 | MP0005195_abnormal_posterior_eye | 0.80316445 |
| 109 | MP0005409_darkened_coat_color | 0.80028762 |
| 110 | MP0003221_abnormal_cardiomyocyte_apopto | 0.79888638 |
| 111 | MP0001145_abnormal_male_reproductive | 0.79441582 |
| 112 | MP0004215_abnormal_myocardial_fiber | 0.79193621 |
| 113 | MP0006072_abnormal_retinal_apoptosis | 0.78416063 |
| 114 | MP0001486_abnormal_startle_reflex | 0.78351405 |
| 115 | MP0002751_abnormal_autonomic_nervous | 0.77251768 |
| 116 | MP0000749_muscle_degeneration | 0.76905009 |
| 117 | MP0003984_embryonic_growth_retardation | 0.76439657 |
| 118 | MP0009046_muscle_twitch | 0.76368292 |
| 119 | MP0005174_abnormal_tail_pigmentation | 0.72045875 |
| 120 | MP0003315_abnormal_perineum_morphology | 0.71835695 |
| 121 | MP0002088_abnormal_embryonic_growth/wei | 0.70983135 |
| 122 | MP0005389_reproductive_system_phenotype | 0.70299602 |
| 123 | MP0002095_abnormal_skin_pigmentation | 0.69792794 |
| 124 | MP0001929_abnormal_gametogenesis | 0.69029489 |
| 125 | MP0005384_cellular_phenotype | 0.68884759 |
| 126 | MP0005386_behavior/neurological_phenoty | 0.67978234 |
| 127 | MP0004924_abnormal_behavior | 0.67978234 |
| 128 | MP0001970_abnormal_pain_threshold | 0.67784670 |
| 129 | MP0002876_abnormal_thyroid_physiology | 0.67099941 |
| 130 | MP0001986_abnormal_taste_sensitivity | 0.66896282 |
| 131 | MP0002084_abnormal_developmental_patter | 0.66561266 |
| 132 | MP0000653_abnormal_sex_gland | 0.64621845 |
| 133 | MP0002163_abnormal_gland_morphology | 0.64308990 |
| 134 | MP0005376_homeostasis/metabolism_phenot | 0.62263293 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.35362246 |
| 2 | Acute necrotizing encephalopathy (HP:0006965) | 4.32147711 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.24336293 |
| 4 | Abnormal number of erythroid precursors (HP:0012131) | 4.19539412 |
| 5 | Abnormal mitochondria in muscle tissue (HP:0008316) | 4.18550044 |
| 6 | Hepatocellular necrosis (HP:0001404) | 4.01054241 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.86926306 |
| 8 | Increased CSF lactate (HP:0002490) | 3.86823083 |
| 9 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.74957213 |
| 10 | Cerebral hypomyelination (HP:0006808) | 3.71783988 |
| 11 | Acute encephalopathy (HP:0006846) | 3.59974035 |
| 12 | Hepatic necrosis (HP:0002605) | 3.57055012 |
| 13 | Increased serum lactate (HP:0002151) | 3.56843748 |
| 14 | Abnormality of glycolysis (HP:0004366) | 3.49282179 |
| 15 | Increased serum pyruvate (HP:0003542) | 3.49282179 |
| 16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.40774192 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.40774192 |
| 18 | Progressive macrocephaly (HP:0004481) | 3.32504277 |
| 19 | Agnosia (HP:0010524) | 3.22078898 |
| 20 | Oral leukoplakia (HP:0002745) | 3.17140395 |
| 21 | Aplastic anemia (HP:0001915) | 3.02524961 |
| 22 | Breast hypoplasia (HP:0003187) | 2.94596145 |
| 23 | Methylmalonic acidemia (HP:0002912) | 2.91921180 |
| 24 | Lactic acidosis (HP:0003128) | 2.90535895 |
| 25 | Reticulocytopenia (HP:0001896) | 2.88559710 |
| 26 | Microvesicular hepatic steatosis (HP:0001414) | 2.83664531 |
| 27 | Pancreatic fibrosis (HP:0100732) | 2.82421658 |
| 28 | 3-Methylglutaconic aciduria (HP:0003535) | 2.79240998 |
| 29 | Ependymoma (HP:0002888) | 2.74870096 |
| 30 | Methylmalonic aciduria (HP:0012120) | 2.74203187 |
| 31 | Pancreatic cysts (HP:0001737) | 2.72099503 |
| 32 | Abnormality of midbrain morphology (HP:0002418) | 2.68973111 |
| 33 | Molar tooth sign on MRI (HP:0002419) | 2.68973111 |
| 34 | Emotional lability (HP:0000712) | 2.67552750 |
| 35 | Rough bone trabeculation (HP:0100670) | 2.54777416 |
| 36 | Unsteady gait (HP:0002317) | 2.54551717 |
| 37 | Nephronophthisis (HP:0000090) | 2.51609134 |
| 38 | Exercise intolerance (HP:0003546) | 2.51235824 |
| 39 | Macrocytic anemia (HP:0001972) | 2.47390060 |
| 40 | Abnormality of the labia minora (HP:0012880) | 2.47166595 |
| 41 | Type I transferrin isoform profile (HP:0003642) | 2.46886714 |
| 42 | Pendular nystagmus (HP:0012043) | 2.46805802 |
| 43 | True hermaphroditism (HP:0010459) | 2.44569914 |
| 44 | CNS hypomyelination (HP:0003429) | 2.44050137 |
| 45 | Degeneration of anterior horn cells (HP:0002398) | 2.42493818 |
| 46 | Abnormality of the anterior horn cell (HP:0006802) | 2.42493818 |
| 47 | Microretrognathia (HP:0000308) | 2.41823043 |
| 48 | Medulloblastoma (HP:0002885) | 2.41312916 |
| 49 | Respiratory failure (HP:0002878) | 2.40956377 |
| 50 | CNS demyelination (HP:0007305) | 2.38752953 |
| 51 | Cerebral edema (HP:0002181) | 2.37268877 |
| 52 | Hypoplasia of the pons (HP:0012110) | 2.36441741 |
| 53 | Increased muscle lipid content (HP:0009058) | 2.34992371 |
| 54 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.34630191 |
| 55 | Carpal bone hypoplasia (HP:0001498) | 2.32927185 |
| 56 | Renal Fanconi syndrome (HP:0001994) | 2.32844821 |
| 57 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.32450491 |
| 58 | Stenosis of the external auditory canal (HP:0000402) | 2.30990058 |
| 59 | Delusions (HP:0000746) | 2.28271941 |
| 60 | Increased hepatocellular lipid droplets (HP:0006565) | 2.26938135 |
| 61 | Colon cancer (HP:0003003) | 2.26243837 |
| 62 | Hyperglycinemia (HP:0002154) | 2.25223044 |
| 63 | Leukodystrophy (HP:0002415) | 2.22676725 |
| 64 | Horseshoe kidney (HP:0000085) | 2.19841501 |
| 65 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.19318204 |
| 66 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.18811481 |
| 67 | Abnormality of alanine metabolism (HP:0010916) | 2.18811481 |
| 68 | Hyperalaninemia (HP:0003348) | 2.18811481 |
| 69 | Abnormality of the preputium (HP:0100587) | 2.18686054 |
| 70 | Type 2 muscle fiber atrophy (HP:0003554) | 2.18517208 |
| 71 | Abnormality of the pons (HP:0007361) | 2.17807266 |
| 72 | Premature graying of hair (HP:0002216) | 2.17337472 |
| 73 | Megaloblastic anemia (HP:0001889) | 2.13981618 |
| 74 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.13423991 |
| 75 | Abnormality of the ileum (HP:0001549) | 2.11636757 |
| 76 | Bone marrow hypocellularity (HP:0005528) | 2.10505255 |
| 77 | Abnormality of the renal collecting system (HP:0004742) | 2.10345214 |
| 78 | Lipid accumulation in hepatocytes (HP:0006561) | 2.09813459 |
| 79 | Selective tooth agenesis (HP:0001592) | 2.09642094 |
| 80 | Congenital stationary night blindness (HP:0007642) | 2.08264671 |
| 81 | Pallor (HP:0000980) | 2.07560889 |
| 82 | Severe visual impairment (HP:0001141) | 2.07529144 |
| 83 | Postnatal microcephaly (HP:0005484) | 2.06747791 |
| 84 | Medial flaring of the eyebrow (HP:0010747) | 2.06743906 |
| 85 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 2.03814824 |
| 86 | Abnormality of chromosome stability (HP:0003220) | 2.03437809 |
| 87 | Patellar aplasia (HP:0006443) | 2.02422576 |
| 88 | Optic disc pallor (HP:0000543) | 2.02348815 |
| 89 | Lethargy (HP:0001254) | 2.01990730 |
| 90 | Meckel diverticulum (HP:0002245) | 2.00288542 |
| 91 | Gliosis (HP:0002171) | 1.98449119 |
| 92 | Ectopic kidney (HP:0000086) | 1.98279151 |
| 93 | Duplicated collecting system (HP:0000081) | 1.97438283 |
| 94 | Abnormality of DNA repair (HP:0003254) | 1.97072357 |
| 95 | Pancytopenia (HP:0001876) | 1.96873983 |
| 96 | Abnormal number of incisors (HP:0011064) | 1.95019157 |
| 97 | Retinal dysplasia (HP:0007973) | 1.94916530 |
| 98 | Muscle fiber atrophy (HP:0100295) | 1.93745283 |
| 99 | Type II lissencephaly (HP:0007260) | 1.93089891 |
| 100 | Sclerocornea (HP:0000647) | 1.92444842 |
| 101 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.91267113 |
| 102 | Small intestinal stenosis (HP:0012848) | 1.91110738 |
| 103 | Duodenal stenosis (HP:0100867) | 1.91110738 |
| 104 | Increased intramyocellular lipid droplets (HP:0012240) | 1.90821152 |
| 105 | Myelodysplasia (HP:0002863) | 1.89798100 |
| 106 | Tongue fasciculations (HP:0001308) | 1.88792588 |
| 107 | Cellular immunodeficiency (HP:0005374) | 1.87457166 |
| 108 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.87323619 |
| 109 | Abnormal lung lobation (HP:0002101) | 1.86599648 |
| 110 | Poor suck (HP:0002033) | 1.85935120 |
| 111 | Rhabdomyosarcoma (HP:0002859) | 1.85677193 |
| 112 | Testicular atrophy (HP:0000029) | 1.85014534 |
| 113 | Aplasia/Hypoplasia of the patella (HP:0006498) | 1.84458957 |
| 114 | Abnormality of the renal medulla (HP:0100957) | 1.84425319 |
| 115 | Ragged-red muscle fibers (HP:0003200) | 1.83756884 |
| 116 | Chromsome breakage (HP:0040012) | 1.83325801 |
| 117 | Optic nerve coloboma (HP:0000588) | 1.83249212 |
| 118 | Absent thumb (HP:0009777) | 1.81966852 |
| 119 | Neuroblastoma (HP:0003006) | 1.81798348 |
| 120 | Primitive neuroectodermal tumor (HP:0030065) | 1.81798348 |
| 121 | Neuroblastic tumors (HP:0004376) | 1.81798348 |
| 122 | Peripheral primitive neuroectodermal neoplasm (HP:0030067) | 1.81798348 |
| 123 | Multiple enchondromatosis (HP:0005701) | 1.81237831 |
| 124 | Abolished electroretinogram (ERG) (HP:0000550) | 1.80560591 |
| 125 | 11 pairs of ribs (HP:0000878) | 1.78909823 |
| 126 | Gait imbalance (HP:0002141) | 1.78220902 |
| 127 | Abnormality of glycine metabolism (HP:0010895) | 1.78072714 |
| 128 | Abnormality of serine family amino acid metabolism (HP:0010894) | 1.78072714 |
| 129 | Abnormal protein glycosylation (HP:0012346) | 1.77016155 |
| 130 | Abnormal glycosylation (HP:0012345) | 1.77016155 |
| 131 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 1.77016155 |
| 132 | Abnormal protein N-linked glycosylation (HP:0012347) | 1.77016155 |
| 133 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.75426288 |
| 134 | Abnormality of serum amino acid levels (HP:0003112) | 1.74404831 |
| 135 | Hyperglycinuria (HP:0003108) | 1.73234581 |
| 136 | Myokymia (HP:0002411) | 1.71547724 |
| 137 | Congenital primary aphakia (HP:0007707) | 1.70875537 |
| 138 | Sloping forehead (HP:0000340) | 1.70799918 |
| 139 | Impulsivity (HP:0100710) | 1.70786363 |
| 140 | Dicarboxylic aciduria (HP:0003215) | 1.69659596 |
| 141 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.69659596 |
| 142 | Limb dystonia (HP:0002451) | 1.68283314 |
| 143 | Exertional dyspnea (HP:0002875) | 1.67485380 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.02174368 |
| 2 | WEE1 | 3.83351714 |
| 3 | VRK2 | 3.53563060 |
| 4 | STK16 | 3.53374447 |
| 5 | TSSK6 | 3.43468320 |
| 6 | CDC7 | 3.31011189 |
| 7 | EIF2AK1 | 3.11123331 |
| 8 | CCNB1 | 2.98844227 |
| 9 | NEK1 | 2.83289174 |
| 10 | WNK3 | 2.57264901 |
| 11 | EIF2AK3 | 2.39842816 |
| 12 | VRK1 | 2.30290990 |
| 13 | SRPK1 | 2.13450743 |
| 14 | MAP4K2 | 2.12143221 |
| 15 | NME2 | 2.05065001 |
| 16 | ACVR1B | 2.01929649 |
| 17 | GRK1 | 1.99978262 |
| 18 | MAP3K12 | 1.98998645 |
| 19 | DAPK1 | 1.96553115 |
| 20 | BRSK1 | 1.94594708 |
| 21 | TRIM28 | 1.90177368 |
| 22 | NUAK1 | 1.85755032 |
| 23 | BMPR1B | 1.73774114 |
| 24 | PASK | 1.70416027 |
| 25 | SCYL2 | 1.62903267 |
| 26 | WNK4 | 1.62558399 |
| 27 | PLK3 | 1.61098463 |
| 28 | BRSK2 | 1.60138939 |
| 29 | PLK1 | 1.56715829 |
| 30 | NME1 | 1.53248338 |
| 31 | CASK | 1.50246505 |
| 32 | CDK19 | 1.48273889 |
| 33 | PDK2 | 1.43727440 |
| 34 | NEK2 | 1.42722950 |
| 35 | BCKDK | 1.40327190 |
| 36 | AURKA | 1.37016114 |
| 37 | TESK2 | 1.36535273 |
| 38 | ATR | 1.36320534 |
| 39 | BRAF | 1.35640627 |
| 40 | TTK | 1.35522390 |
| 41 | CSNK1G2 | 1.32140812 |
| 42 | FRK | 1.28900185 |
| 43 | MKNK1 | 1.24763150 |
| 44 | CSNK1G1 | 1.23032074 |
| 45 | PHKG1 | 1.19271853 |
| 46 | PHKG2 | 1.19271853 |
| 47 | PLK4 | 1.18604612 |
| 48 | PBK | 1.17632022 |
| 49 | DYRK3 | 1.16509506 |
| 50 | CSNK1A1L | 1.08465409 |
| 51 | AURKB | 1.08189616 |
| 52 | CDK7 | 1.03170541 |
| 53 | TAF1 | 1.03153444 |
| 54 | CHEK2 | 1.01253720 |
| 55 | TNIK | 1.00496062 |
| 56 | ARAF | 0.96434253 |
| 57 | SIK3 | 0.90271476 |
| 58 | STK39 | 0.88489350 |
| 59 | OXSR1 | 0.87874364 |
| 60 | UHMK1 | 0.86361570 |
| 61 | AKT3 | 0.85873441 |
| 62 | TLK1 | 0.84603039 |
| 63 | PDK4 | 0.84479675 |
| 64 | PDK3 | 0.84479675 |
| 65 | CHEK1 | 0.81564550 |
| 66 | MAP2K7 | 0.81280573 |
| 67 | OBSCN | 0.81114063 |
| 68 | CDK8 | 0.80358363 |
| 69 | RPS6KA5 | 0.79699247 |
| 70 | MKNK2 | 0.78920770 |
| 71 | GRK6 | 0.78680925 |
| 72 | RPS6KB2 | 0.76112702 |
| 73 | MINK1 | 0.73005206 |
| 74 | CSNK2A2 | 0.69776042 |
| 75 | PIM2 | 0.69503135 |
| 76 | CSNK2A1 | 0.68509067 |
| 77 | LIMK1 | 0.66607981 |
| 78 | CDK18 | 0.64626973 |
| 79 | EIF2AK2 | 0.64121216 |
| 80 | NTRK3 | 0.63140642 |
| 81 | MAPKAPK3 | 0.62690201 |
| 82 | KDR | 0.62515337 |
| 83 | CDK4 | 0.61747014 |
| 84 | DYRK2 | 0.61680214 |
| 85 | DAPK2 | 0.59768582 |
| 86 | CDK15 | 0.59635429 |
| 87 | PLK2 | 0.59464020 |
| 88 | CDK11A | 0.58173867 |
| 89 | RPS6KA4 | 0.57692414 |
| 90 | CSNK1A1 | 0.57186432 |
| 91 | INSRR | 0.56688044 |
| 92 | ZAK | 0.56680839 |
| 93 | CDK2 | 0.55780529 |
| 94 | PAK4 | 0.55497751 |
| 95 | MAP3K8 | 0.53954700 |
| 96 | BCR | 0.53673442 |
| 97 | MAPK13 | 0.52982036 |
| 98 | ALK | 0.52700581 |
| 99 | CDK14 | 0.52609545 |
| 100 | PRKCI | 0.52544262 |
| 101 | ATM | 0.47426541 |
| 102 | PAK1 | 0.47420696 |
| 103 | ERBB3 | 0.47298810 |
| 104 | PRKCE | 0.46110111 |
| 105 | EPHA4 | 0.46081152 |
| 106 | PINK1 | 0.46069479 |
| 107 | PRKCG | 0.46000130 |
| 108 | TGFBR1 | 0.45392967 |
| 109 | CDK1 | 0.44990019 |
| 110 | MAP2K3 | 0.44713912 |
| 111 | STK38L | 0.43730175 |
| 112 | PNCK | 0.43220664 |
| 113 | MUSK | 0.42367709 |
| 114 | PAK3 | 0.42213589 |
| 115 | FLT3 | 0.41327854 |
| 116 | CAMK2A | 0.40694233 |
| 117 | MAPKAPK5 | 0.39531758 |
| 118 | AKT2 | 0.39068638 |
| 119 | ADRBK2 | 0.36262434 |
| 120 | ADRBK1 | 0.35827453 |
| 121 | DAPK3 | 0.34417371 |
| 122 | MAP3K11 | 0.34132316 |
| 123 | MST4 | 0.33831275 |
| 124 | MAP2K6 | 0.33107924 |
| 125 | MARK1 | 0.31203159 |
| 126 | RPS6KL1 | 0.31185631 |
| 127 | RPS6KC1 | 0.31185631 |
| 128 | GRK5 | 0.30347022 |
| 129 | RPS6KB1 | 0.30167626 |
| 130 | YES1 | 0.28606575 |
| 131 | ABL2 | 0.28322640 |
| 132 | RAF1 | 0.28091666 |
| 133 | MAP3K4 | 0.27744743 |
| 134 | CSNK1G3 | 0.27228850 |
| 135 | CSNK1E | 0.26832671 |
| 136 | TAOK2 | 0.26411867 |
| 137 | SYK | 0.25457360 |
| 138 | MYLK | 0.24428556 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 5.21556552 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 4.32751458 |
| 3 | Proteasome_Homo sapiens_hsa03050 | 4.20867884 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.33190032 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.11126737 |
| 6 | RNA polymerase_Homo sapiens_hsa03020 | 3.08085891 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.94608533 |
| 8 | Homologous recombination_Homo sapiens_hsa03440 | 2.89096322 |
| 9 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.74319782 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.71048493 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.70287619 |
| 12 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.57964462 |
| 13 | RNA transport_Homo sapiens_hsa03013 | 2.39447986 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.38507451 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 2.33044930 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.25068578 |
| 17 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 2.08542564 |
| 18 | Cell cycle_Homo sapiens_hsa04110 | 1.92040222 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.82872862 |
| 20 | Huntingtons disease_Homo sapiens_hsa05016 | 1.75651953 |
| 21 | Protein export_Homo sapiens_hsa03060 | 1.66193824 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.63546240 |
| 23 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.63497654 |
| 24 | Purine metabolism_Homo sapiens_hsa00230 | 1.53842882 |
| 25 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.53237011 |
| 26 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.47930452 |
| 27 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.38580385 |
| 28 | Alzheimers disease_Homo sapiens_hsa05010 | 1.36011499 |
| 29 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.35360823 |
| 30 | Basal transcription factors_Homo sapiens_hsa03022 | 1.31336410 |
| 31 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.28163514 |
| 32 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.17755267 |
| 33 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.13398130 |
| 34 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.10573865 |
| 35 | Carbon metabolism_Homo sapiens_hsa01200 | 1.08593468 |
| 36 | Sulfur relay system_Homo sapiens_hsa04122 | 1.08492743 |
| 37 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.97137468 |
| 38 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.96877445 |
| 39 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.96874702 |
| 40 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.96637968 |
| 41 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.94595103 |
| 42 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.93500326 |
| 43 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.93293700 |
| 44 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.91122892 |
| 45 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.90797035 |
| 46 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.89833011 |
| 47 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.83851367 |
| 48 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.83744782 |
| 49 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.81961441 |
| 50 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.81682086 |
| 51 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.79811641 |
| 52 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.77596600 |
| 53 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.73181067 |
| 54 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.72211105 |
| 55 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.71258636 |
| 56 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.68246313 |
| 57 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.67710459 |
| 58 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.67036940 |
| 59 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.66358186 |
| 60 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.63896209 |
| 61 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.63804064 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.60792784 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.60439880 |
| 64 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.60426165 |
| 65 | Nicotine addiction_Homo sapiens_hsa05033 | 0.58749772 |
| 66 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.58267822 |
| 67 | Alcoholism_Homo sapiens_hsa05034 | 0.56999612 |
| 68 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.56461015 |
| 69 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.55854224 |
| 70 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.55134443 |
| 71 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.54962498 |
| 72 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.53585589 |
| 73 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.52719125 |
| 74 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.52481930 |
| 75 | Galactose metabolism_Homo sapiens_hsa00052 | 0.47859726 |
| 76 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.47817823 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.47658826 |
| 78 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.45742442 |
| 79 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.43605695 |
| 80 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.41173365 |
| 81 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.40350412 |
| 82 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.38029755 |
| 83 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.36565426 |
| 84 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.34889757 |
| 85 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34311354 |
| 86 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.34251286 |
| 87 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.32420590 |
| 88 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.30887913 |
| 89 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.29478621 |
| 90 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.27540694 |
| 91 | Morphine addiction_Homo sapiens_hsa05032 | 0.27148449 |
| 92 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.26911912 |
| 93 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.26308643 |
| 94 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.25829090 |
| 95 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.25813219 |
| 96 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.25534009 |
| 97 | Retinol metabolism_Homo sapiens_hsa00830 | 0.24986987 |
| 98 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.23838374 |
| 99 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.23323191 |
| 100 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.23057194 |
| 101 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.21848687 |
| 102 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.21826271 |
| 103 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.20965999 |
| 104 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.19299389 |
| 105 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.18906978 |
| 106 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.18316384 |
| 107 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.17621093 |
| 108 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.15145593 |
| 109 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.14412540 |
| 110 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 0.13369823 |
| 111 | Taste transduction_Homo sapiens_hsa04742 | 0.12767672 |
| 112 | Legionellosis_Homo sapiens_hsa05134 | 0.11303233 |
| 113 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.11017622 |
| 114 | Dopaminergic synapse_Homo sapiens_hsa04728 | 0.10542079 |
| 115 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.08929857 |
| 116 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.08194165 |
| 117 | GABAergic synapse_Homo sapiens_hsa04727 | 0.07475938 |
| 118 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.06889850 |
| 119 | Peroxisome_Homo sapiens_hsa04146 | 0.06783631 |
| 120 | Olfactory transduction_Homo sapiens_hsa04740 | 0.06532172 |
| 121 | Thyroid cancer_Homo sapiens_hsa05216 | 0.06256223 |
| 122 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.06153304 |
| 123 | Phototransduction_Homo sapiens_hsa04744 | 0.03526980 |
| 124 | HTLV-I infection_Homo sapiens_hsa05166 | 0.01968162 |
| 125 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.01703165 |
| 126 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.00781775 |

