AASDH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the non-ribosome peptide syntesase (NRPS) enzyme family. The encoded protein contains an AMP-binding domain, PP-binding (phosphopantetheine, or pantetheine 4'phosphate-binding) domain and the Pyrrolo-quinoline quinon (PQQ) binding domain. The protein is expressed in several adult tissues. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)6.11698246
2polyketide metabolic process (GO:0030638)6.11698246
3doxorubicin metabolic process (GO:0044598)6.11698246
4G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.46735714
5CENP-A containing nucleosome assembly (GO:0034080)4.25183661
6mesenchymal cell differentiation involved in renal system development (GO:2001012)4.24294880
7mesenchymal cell differentiation involved in kidney development (GO:0072161)4.24294880
8chromatin remodeling at centromere (GO:0031055)4.21098183
9regulation of meiosis I (GO:0060631)4.17115465
10energy homeostasis (GO:0097009)4.11838221
11establishment of protein localization to mitochondrial membrane (GO:0090151)3.85013363
12regulation of DNA endoreduplication (GO:0032875)3.73988486
13histone H2A acetylation (GO:0043968)3.72089882
14regulation of activation of Janus kinase activity (GO:0010533)3.69220273
15DNA strand renaturation (GO:0000733)3.68838438
16oligosaccharide catabolic process (GO:0009313)3.68330454
17centriole assembly (GO:0098534)3.65215679
18histone exchange (GO:0043486)3.58274002
19aminoglycoside antibiotic metabolic process (GO:0030647)3.56372552
20intraciliary transport (GO:0042073)3.50296218
21neuron cell-cell adhesion (GO:0007158)3.49290470
22protein K6-linked ubiquitination (GO:0085020)3.46524893
23post-embryonic morphogenesis (GO:0009886)3.37707787
24ceramide catabolic process (GO:0046514)3.37063047
25presynaptic membrane assembly (GO:0097105)3.34107800
26regulation of nuclear cell cycle DNA replication (GO:0033262)3.34023214
27kinetochore assembly (GO:0051382)3.33999945
28pyrimidine dimer repair (GO:0006290)3.31182986
29nonmotile primary cilium assembly (GO:0035058)3.28048260
30DNA replication-independent nucleosome assembly (GO:0006336)3.24562052
31DNA replication-independent nucleosome organization (GO:0034724)3.24562052
32purinergic nucleotide receptor signaling pathway (GO:0035590)3.24133567
33ribosomal small subunit assembly (GO:0000028)3.19471228
34positive regulation of uterine smooth muscle contraction (GO:0070474)3.17471690
35single strand break repair (GO:0000012)3.16968603
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.14885915
37glycosphingolipid catabolic process (GO:0046479)3.11135046
38mitotic sister chromatid cohesion (GO:0007064)3.09800978
39negative regulation of meiosis (GO:0045835)3.09768350
40poly(A)+ mRNA export from nucleus (GO:0016973)3.06172791
41protein localization to kinetochore (GO:0034501)3.04620505
42mitotic metaphase plate congression (GO:0007080)2.98531765
43regulation of helicase activity (GO:0051095)2.98041824
44negative regulation of DNA-dependent DNA replication (GO:2000104)2.97728495
45regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97724233
46regulation of mitotic spindle checkpoint (GO:1903504)2.97724233
47mature B cell differentiation involved in immune response (GO:0002313)2.96905030
48postreplication repair (GO:0006301)2.96146521
49DNA integration (GO:0015074)2.95123752
50regulation of centriole replication (GO:0046599)2.92950738
51resolution of meiotic recombination intermediates (GO:0000712)2.92627393
52negative regulation of telomere maintenance (GO:0032205)2.91943495
53histone H3-K4 trimethylation (GO:0080182)2.91917107
54meiotic chromosome segregation (GO:0045132)2.90504088
55negative regulation of DNA recombination (GO:0045910)2.90455143
56centriole replication (GO:0007099)2.90373763
57histone mRNA metabolic process (GO:0008334)2.89764742
58kinetochore organization (GO:0051383)2.87196704
59positive regulation of T cell mediated cytotoxicity (GO:0001916)2.87127518
60maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.86213193
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.85662561
62neural tube formation (GO:0001841)2.84970513
63tRNA methylation (GO:0030488)2.84333083
64presynaptic membrane organization (GO:0097090)2.84272628
65DNA synthesis involved in DNA repair (GO:0000731)2.84229926
66DNA ligation (GO:0006266)2.82091141
67microtubule depolymerization (GO:0007019)2.81619655
68metaphase plate congression (GO:0051310)2.80231391
69female gonad development (GO:0008585)2.79881474
70cullin deneddylation (GO:0010388)2.79812441
71replication fork processing (GO:0031297)2.79238855
72cell differentiation involved in metanephros development (GO:0072202)2.78701156
73auditory receptor cell stereocilium organization (GO:0060088)2.78092359
74DNA catabolic process, exonucleolytic (GO:0000738)2.77911263
75proteasome assembly (GO:0043248)2.77849873
76regulation of hexokinase activity (GO:1903299)2.77777395
77regulation of glucokinase activity (GO:0033131)2.77777395
78superoxide anion generation (GO:0042554)2.76635260
79DNA damage response, detection of DNA damage (GO:0042769)2.76319922
80otic vesicle formation (GO:0030916)2.76093205
81nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74563122
82exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72199236
83nucleoside diphosphate catabolic process (GO:0009134)2.71476689
84prenylation (GO:0097354)2.71338804
85protein prenylation (GO:0018342)2.71338804
86mature B cell differentiation (GO:0002335)2.70152929
87reciprocal meiotic recombination (GO:0007131)2.69681820
88reciprocal DNA recombination (GO:0035825)2.69681820
89microtubule anchoring (GO:0034453)2.69407790
90glycolipid catabolic process (GO:0019377)2.68549037
91water-soluble vitamin biosynthetic process (GO:0042364)2.67753877
92negative regulation of keratinocyte proliferation (GO:0010839)2.67710297
93negative regulation of mast cell activation (GO:0033004)2.67508984
94cellular response to gamma radiation (GO:0071480)2.67457588
95replicative senescence (GO:0090399)2.67092793
96regulation of histone H3-K27 methylation (GO:0061085)2.66818309
97atrial cardiac muscle cell action potential (GO:0086014)2.65627736
98behavioral response to nicotine (GO:0035095)2.65389422
99spindle checkpoint (GO:0031577)2.64613781
100establishment of integrated proviral latency (GO:0075713)2.64221356
101detection of molecule of bacterial origin (GO:0032490)2.61840173
102regulation of timing of cell differentiation (GO:0048505)2.60239106
103epithelial cilium movement (GO:0003351)2.59746874
104purine nucleobase biosynthetic process (GO:0009113)2.59567468
105negative regulation of norepinephrine secretion (GO:0010700)2.58359027
106prostate gland growth (GO:0060736)2.57991183
107inner ear receptor stereocilium organization (GO:0060122)2.57943849
108cellular anion homeostasis (GO:0030002)2.57641762
109synapsis (GO:0007129)2.57362973
110sequestering of actin monomers (GO:0042989)2.56352340
111DNA replication-dependent nucleosome assembly (GO:0006335)2.55457755
112DNA replication-dependent nucleosome organization (GO:0034723)2.55457755
113piRNA metabolic process (GO:0034587)2.55352776
114double-strand break repair via nonhomologous end joining (GO:0006303)2.54130972
115non-recombinational repair (GO:0000726)2.54130972
116mismatch repair (GO:0006298)2.53834460
117lymph node development (GO:0048535)2.53354306
118negative regulation of translation, ncRNA-mediated (GO:0040033)2.53323288
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.53323288
120recombinational repair (GO:0000725)2.52977580
121DNA replication initiation (GO:0006270)2.52677250
122histone mRNA catabolic process (GO:0071044)2.52444332
123double-strand break repair via homologous recombination (GO:0000724)2.51444118
124positive regulation of mRNA processing (GO:0050685)2.51071578
125cilium morphogenesis (GO:0060271)2.50678605
126positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.50350642
127mitotic spindle checkpoint (GO:0071174)2.49688112
128detection of bacterium (GO:0016045)2.49068361
129protein deneddylation (GO:0000338)2.47140027
130energy coupled proton transport, down electrochemical gradient (GO:0015985)2.46962004
131ATP synthesis coupled proton transport (GO:0015986)2.46962004
132ncRNA catabolic process (GO:0034661)2.46663318
133DNA double-strand break processing (GO:0000729)2.45016242
134sister chromatid cohesion (GO:0007062)2.43251676
135mechanosensory behavior (GO:0007638)2.43083150
136nucleotide-excision repair, DNA gap filling (GO:0006297)2.42800032
137regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.42753945
138regulation of memory T cell differentiation (GO:0043380)2.42714431
139mRNA splice site selection (GO:0006376)2.42479466
140negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41011028
141negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41011028
142negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41011028
143negative regulation of mitotic sister chromatid separation (GO:2000816)2.41011028
144negative regulation of sister chromatid segregation (GO:0033046)2.41011028
145somite development (GO:0061053)2.41006317
146regulation of development, heterochronic (GO:0040034)2.40574444
147interferon-gamma production (GO:0032609)2.40478306
148somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39772027
149somatic hypermutation of immunoglobulin genes (GO:0016446)2.39772027
150positive regulation of megakaryocyte differentiation (GO:0045654)2.39746248
151detection of external biotic stimulus (GO:0098581)2.39608004
152positive regulation of DNA-dependent DNA replication (GO:2000105)2.39008341
153detection of other organism (GO:0098543)2.38672846
154limb bud formation (GO:0060174)2.38579451
155rRNA catabolic process (GO:0016075)2.37594139
156DNA-dependent DNA replication (GO:0006261)2.37480671
157regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.37421981
158respiratory chain complex IV assembly (GO:0008535)2.37303063
159rRNA methylation (GO:0031167)2.37173945
160cilium assembly (GO:0042384)2.36512328
161CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.36214856
162regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36108224
163preassembly of GPI anchor in ER membrane (GO:0016254)2.35933403
164histone H3-K9 modification (GO:0061647)2.35494577
165telomere maintenance via telomerase (GO:0007004)2.35175329
166cilium organization (GO:0044782)2.34932770
167histone H3-K9 methylation (GO:0051567)2.34769106
168protein K11-linked ubiquitination (GO:0070979)2.34100548
169response to X-ray (GO:0010165)2.33667030
170chaperone-mediated protein transport (GO:0072321)2.33402301
171DNA methylation involved in gamete generation (GO:0043046)2.33045544
172RNA methylation (GO:0001510)2.32916349
173adenosine metabolic process (GO:0046085)2.31547734
174regulation of uterine smooth muscle contraction (GO:0070472)2.31170467
175deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.31124800
176dentate gyrus development (GO:0021542)2.30919314
177positive regulation of defense response to virus by host (GO:0002230)2.30754580
178interkinetic nuclear migration (GO:0022027)2.30716449
179positive regulation of granulocyte differentiation (GO:0030854)2.27243395
180cell differentiation involved in kidney development (GO:0061005)2.26259309
181regulation of telomere maintenance (GO:0032204)2.26251087
182facial nerve structural organization (GO:0021612)2.25421080
183activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.24854387
184cell proliferation in forebrain (GO:0021846)2.23327922
185negative regulation of granulocyte differentiation (GO:0030853)2.20961065
186regulation of translation, ncRNA-mediated (GO:0045974)2.20740067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.27494275
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.50523719
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.12253074
4NOTCH1_21737748_ChIP-Seq_TLL_Human3.09006500
5GBX2_23144817_ChIP-Seq_PC3_Human3.07729045
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.96252945
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.89384396
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85015950
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.78840834
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.77781824
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.71531009
12ZNF274_21170338_ChIP-Seq_K562_Hela2.55563760
13SUZ12_27294783_Chip-Seq_NPCs_Mouse2.42212441
14NFE2_27457419_Chip-Seq_LIVER_Mouse2.41259579
15ELK1_19687146_ChIP-ChIP_HELA_Human2.39450662
16VDR_22108803_ChIP-Seq_LS180_Human2.31450482
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29993108
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21771828
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.21764265
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18450196
21PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08220229
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.03948382
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.02569241
24* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94021905
25* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.93933714
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93057830
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92899715
28IRF1_19129219_ChIP-ChIP_H3396_Human1.92327161
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90285936
30STAT3_18555785_Chip-Seq_ESCs_Mouse1.89384356
31EZH2_22144423_ChIP-Seq_EOC_Human1.88911186
32EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.88506946
33EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.84341744
34E2F1_18555785_Chip-Seq_ESCs_Mouse1.83704652
35P53_22387025_ChIP-Seq_ESCs_Mouse1.83594645
36RUNX1_27457419_Chip-Seq_LIVER_Mouse1.83574140
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83418733
38HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.82537367
39EWS_26573619_Chip-Seq_HEK293_Human1.81260980
40SUZ12_18555785_Chip-Seq_ESCs_Mouse1.81228229
41NANOG_18555785_Chip-Seq_ESCs_Mouse1.78722023
42TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77695627
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77314775
44PADI4_21655091_ChIP-ChIP_MCF-7_Human1.76543731
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76518204
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.76056539
47* VDR_23849224_ChIP-Seq_CD4+_Human1.74680502
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72158948
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70004618
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69556528
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.69333342
52P300_18555785_Chip-Seq_ESCs_Mouse1.66716707
53FOXP3_21729870_ChIP-Seq_TREG_Human1.64442190
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.63906148
55OCT4_18555785_Chip-Seq_ESCs_Mouse1.62075363
56E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60203101
57RNF2_27304074_Chip-Seq_NSC_Mouse1.59818309
58* ETS1_20019798_ChIP-Seq_JURKAT_Human1.59493291
59SOX2_18555785_Chip-Seq_ESCs_Mouse1.57975780
60FUS_26573619_Chip-Seq_HEK293_Human1.57650080
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.56914451
62PU1_27457419_Chip-Seq_LIVER_Mouse1.56611782
63MYC_18940864_ChIP-ChIP_HL60_Human1.54173131
64ESRRB_18555785_Chip-Seq_ESCs_Mouse1.53550708
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49905544
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.47416324
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.46720319
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46478208
69NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45609847
70* P300_19829295_ChIP-Seq_ESCs_Human1.43314822
71SMAD1_18555785_Chip-Seq_ESCs_Mouse1.43170820
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.42654017
73IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.40128983
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.39918437
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.39780227
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.36407274
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.35831813
78* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33607575
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.33134709
80* SOX2_16153702_ChIP-ChIP_HESCs_Human1.32316053
81SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31914813
82OCT4_21477851_ChIP-Seq_ESCs_Mouse1.31304721
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29831010
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29015307
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28796303
86TAF15_26573619_Chip-Seq_HEK293_Human1.28489098
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27488081
88IRF8_21731497_ChIP-ChIP_J774_Mouse1.27104584
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26139192
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26097034
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23483827
92SRF_21415370_ChIP-Seq_HL-1_Mouse1.22909717
93* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.19221866
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19083283
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.18480861
96ER_23166858_ChIP-Seq_MCF-7_Human1.17909135
97FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17593444
98KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16807519
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16041575
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.15782320
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15759582
102CBP_20019798_ChIP-Seq_JUKART_Human1.15759582
103GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14464900
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13011430
105* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12865664
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.12853017
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12025301
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12025301
109FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11866054
110STAT3_23295773_ChIP-Seq_U87_Human1.10644088
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10549247
112PIAS1_25552417_ChIP-Seq_VCAP_Human1.10504469
113IGF1R_20145208_ChIP-Seq_DFB_Human1.10278483
114DCP1A_22483619_ChIP-Seq_HELA_Human1.10262239
115E2F1_21310950_ChIP-Seq_MCF-7_Human1.09675063
116* NANOG_16153702_ChIP-ChIP_HESCs_Human1.09107082
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08633813
118BCAT_22108803_ChIP-Seq_LS180_Human1.08391320
119IRF8_22096565_ChIP-ChIP_GC-B_Human1.07305151
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05835210
121* TTF2_22483619_ChIP-Seq_HELA_Human1.05633961
122SCL_19346495_ChIP-Seq_HPC-7_Human1.04998413
123KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.04151464
124TP53_22573176_ChIP-Seq_HFKS_Human1.01264644
125HTT_18923047_ChIP-ChIP_STHdh_Human1.01239655
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00975454
127NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00742354
128AR_25329375_ChIP-Seq_VCAP_Human0.99140272
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98894158
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98082864
131SOX9_26525672_Chip-Seq_HEART_Mouse0.97586290
132MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97192445
133TCF4_22108803_ChIP-Seq_LS180_Human0.96193337
134EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96058462
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95288214
136TCF4_23295773_ChIP-Seq_U87_Human0.93651688
137* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.93455059
138FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.92586672
139GF1B_26923725_Chip-Seq_HPCs_Mouse0.92214876
140PHF8_20622853_ChIP-Seq_HELA_Human0.89831166
141TBL1_22424771_ChIP-Seq_293T_Human0.89639826
142SMAD3_21741376_ChIP-Seq_EPCs_Human0.89141524
143SMAD4_21799915_ChIP-Seq_A2780_Human0.88832004
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88727292
145FOXM1_23109430_ChIP-Seq_U2OS_Human0.88571368
146NFYB_21822215_ChIP-Seq_K562_Human0.88294020
147ETV1_20927104_ChIP-Seq_GIST48_Human0.88259312
148PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.86704039
149HNFA_21074721_ChIP-Seq_CACO-2_Human0.84857386
150KDM2B_26808549_Chip-Seq_REH_Human0.84855831

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.66915047
2MP0008057_abnormal_DNA_replication3.16707510
3MP0000566_synostosis3.05368634
4MP0003787_abnormal_imprinting2.95808701
5MP0003890_abnormal_embryonic-extraembry2.94410366
6MP0001986_abnormal_taste_sensitivity2.90021483
7MP0005646_abnormal_pituitary_gland2.77322350
8MP0001188_hyperpigmentation2.62963766
9MP0002102_abnormal_ear_morphology2.58203005
10MP0009697_abnormal_copulation2.54544356
11MP0008058_abnormal_DNA_repair2.50644598
12MP0005645_abnormal_hypothalamus_physiol2.41786347
13MP0006072_abnormal_retinal_apoptosis2.31657915
14MP0003880_abnormal_central_pattern2.26088830
15MP0003136_yellow_coat_color2.11910772
16MP0005409_darkened_coat_color2.06078350
17MP0002638_abnormal_pupillary_reflex2.03500685
18MP0010094_abnormal_chromosome_stability1.99176187
19MP0001835_abnormal_antigen_presentation1.98658533
20MP0005423_abnormal_somatic_nervous1.95322707
21MP0000015_abnormal_ear_pigmentation1.91412123
22MP0002277_abnormal_respiratory_mucosa1.90749521
23MP0008995_early_reproductive_senescence1.82907364
24MP0000569_abnormal_digit_pigmentation1.82679856
25MP0008877_abnormal_DNA_methylation1.82210748
26MP0003111_abnormal_nucleus_morphology1.81168798
27MP0005171_absent_coat_pigmentation1.79709894
28MP0002396_abnormal_hematopoietic_system1.79557184
29MP0005394_taste/olfaction_phenotype1.77438656
30MP0005499_abnormal_olfactory_system1.77438656
31MP0006035_abnormal_mitochondrial_morpho1.76026132
32MP0003121_genomic_imprinting1.69207744
33MP0003567_abnormal_fetal_cardiomyocyte1.66339145
34MP0002233_abnormal_nose_morphology1.66127212
35MP0008007_abnormal_cellular_replicative1.64020291
36MP0002876_abnormal_thyroid_physiology1.62856032
37MP0004381_abnormal_hair_follicle1.61982558
38MP0005671_abnormal_response_to1.61035234
39MP0003786_premature_aging1.60383641
40MP0002132_abnormal_respiratory_system1.60194118
41MP0005253_abnormal_eye_physiology1.58363396
42MP0003937_abnormal_limbs/digits/tail_de1.58289928
43MP0003868_abnormal_feces_composition1.53678498
44MP0002938_white_spotting1.52309328
45MP0002653_abnormal_ependyma_morphology1.52137987
46MP0002095_abnormal_skin_pigmentation1.50865337
47MP0000778_abnormal_nervous_system1.50285086
48MP0001529_abnormal_vocalization1.50032852
49MP0005379_endocrine/exocrine_gland_phen1.47382524
50MP0004133_heterotaxia1.47016854
51MP0001764_abnormal_homeostasis1.46714206
52MP0005174_abnormal_tail_pigmentation1.45349526
53MP0003693_abnormal_embryo_hatching1.45052723
54MP0004957_abnormal_blastocyst_morpholog1.44947438
55MP0008932_abnormal_embryonic_tissue1.38736240
56MP0004885_abnormal_endolymph1.36780060
57MP0002736_abnormal_nociception_after1.36493137
58MP0000613_abnormal_salivary_gland1.36027867
59MP0002282_abnormal_trachea_morphology1.34679835
60MP0005377_hearing/vestibular/ear_phenot1.32986760
61MP0003878_abnormal_ear_physiology1.32986760
62MP0010386_abnormal_urinary_bladder1.31942597
63MP0000049_abnormal_middle_ear1.30827618
64MP0001286_abnormal_eye_development1.30729604
65MP0002751_abnormal_autonomic_nervous1.28285190
66MP0000647_abnormal_sebaceous_gland1.26273213
67MP0003077_abnormal_cell_cycle1.23567560
68MP0001984_abnormal_olfaction1.22852762
69MP0003283_abnormal_digestive_organ1.22390895
70MP0004147_increased_porphyrin_level1.21677374
71MP0000678_abnormal_parathyroid_gland1.21414448
72MP0000427_abnormal_hair_cycle1.21156126
73MP0005084_abnormal_gallbladder_morpholo1.20397039
74MP0001919_abnormal_reproductive_system1.18033381
75MP0003941_abnormal_skin_development1.17297911
76MP0001929_abnormal_gametogenesis1.17169186
77MP0005391_vision/eye_phenotype1.16868242
78MP0002138_abnormal_hepatobiliary_system1.16034628
79MP0000631_abnormal_neuroendocrine_gland1.13632418
80MP0006036_abnormal_mitochondrial_physio1.13622677
81MP0000372_irregular_coat_pigmentation1.13225327
82MP0008004_abnormal_stomach_pH1.12499799
83MP0004142_abnormal_muscle_tone1.11336417
84MP0000653_abnormal_sex_gland1.10884382
85MP0005387_immune_system_phenotype1.10577517
86MP0001790_abnormal_immune_system1.10577517
87MP0002837_dystrophic_cardiac_calcinosis1.10005327
88MP0005075_abnormal_melanosome_morpholog1.08842250
89MP0001145_abnormal_male_reproductive1.07239070
90MP0005248_abnormal_Harderian_gland1.06950015
91MP0002234_abnormal_pharynx_morphology1.06693229
92MP0001800_abnormal_humoral_immune1.06438881
93MP0004782_abnormal_surfactant_physiolog1.05912339
94MP0003122_maternal_imprinting1.05748558
95MP0001119_abnormal_female_reproductive1.05740398
96MP0002163_abnormal_gland_morphology1.05373698
97MP0010030_abnormal_orbit_morphology1.04276137
98MP0003763_abnormal_thymus_physiology1.03722984
99MP0003195_calcinosis1.03199449
100MP0002697_abnormal_eye_size1.02869174
101MP0008789_abnormal_olfactory_epithelium1.02675066
102MP0005389_reproductive_system_phenotype1.01136800
103MP0002084_abnormal_developmental_patter1.00163953
104MP0003698_abnormal_male_reproductive0.99180823
105MP0005451_abnormal_body_composition0.99045831
106MP0000383_abnormal_hair_follicle0.98157532
107MP0003861_abnormal_nervous_system0.96719903
108MP0005187_abnormal_penis_morphology0.96091422
109MP0009785_altered_susceptibility_to0.95436315
110MP0002210_abnormal_sex_determination0.95247365
111MP0001502_abnormal_circadian_rhythm0.95185682
112MP0001324_abnormal_eye_pigmentation0.94114232
113MP0003938_abnormal_ear_development0.93295245
114MP0003119_abnormal_digestive_system0.91325639
115MP0002452_abnormal_antigen_presenting0.91217362
116MP0001186_pigmentation_phenotype0.91126316
117MP0006276_abnormal_autonomic_nervous0.91072525
118MP0005195_abnormal_posterior_eye0.86956359
119MP0003755_abnormal_palate_morphology0.86883041
120MP0002752_abnormal_somatic_nervous0.85920885
121MP0003045_fibrosis0.85721668
122MP0002148_abnormal_hypersensitivity_rea0.84669442
123MP0005670_abnormal_white_adipose0.84549727
124MP0005647_abnormal_sex_gland0.84456383
125MP0002184_abnormal_innervation0.84009616
126MP0005464_abnormal_platelet_physiology0.83566353
127MP0001486_abnormal_startle_reflex0.82896826
128MP0000358_abnormal_cell_content/0.82456118
129MP0000681_abnormal_thyroid_gland0.81934102
130MP0002419_abnormal_innate_immunity0.81830831
131MP0001485_abnormal_pinna_reflex0.81320258
132MP0000428_abnormal_craniofacial_morphol0.79913135
133MP0002420_abnormal_adaptive_immunity0.79204810
134MP0001819_abnormal_immune_cell0.79203210
135MP0002090_abnormal_vision0.79109622
136MP0009379_abnormal_foot_pigmentation0.79017919
137MP0002723_abnormal_immune_serum0.78860524
138MP0005025_abnormal_response_to0.78661491
139MP0004742_abnormal_vestibular_system0.78086305
140MP0005310_abnormal_salivary_gland0.77512618
141MP0002177_abnormal_outer_ear0.77308785
142MP0001963_abnormal_hearing_physiology0.77111400
143MP0002160_abnormal_reproductive_system0.76568212
144MP0001968_abnormal_touch/_nociception0.76371574
145MP0002398_abnormal_bone_marrow0.75563582
146MP0003879_abnormal_hair_cell0.75372152
147MP0000026_abnormal_inner_ear0.75330280
148MP0003718_maternal_effect0.75149229
149MP0005551_abnormal_eye_electrophysiolog0.73586463
150MP0002075_abnormal_coat/hair_pigmentati0.73462026
151MP0000470_abnormal_stomach_morphology0.72157898
152MP0001873_stomach_inflammation0.71947508
153MP0001293_anophthalmia0.71087843
154MP0006082_CNS_inflammation0.70923743
155MP0002928_abnormal_bile_duct0.70847172

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.56807023
2Chromsome breakage (HP:0040012)5.15393750
3Abnormality of the renal collecting system (HP:0004742)3.85487044
4Duplicated collecting system (HP:0000081)3.80053764
5White forelock (HP:0002211)3.37812088
6Colon cancer (HP:0003003)3.23685107
7Abnormality of DNA repair (HP:0003254)3.16102010
8Patchy hypopigmentation of hair (HP:0011365)3.14374472
9Birth length less than 3rd percentile (HP:0003561)3.14313540
10Volvulus (HP:0002580)3.14107195
11Nephrogenic diabetes insipidus (HP:0009806)3.04348751
12Medial flaring of the eyebrow (HP:0010747)2.96407671
13Abnormality of the preputium (HP:0100587)2.88270567
14Lip pit (HP:0100267)2.86960006
15Aplasia/Hypoplasia of the uvula (HP:0010293)2.77593226
16Septo-optic dysplasia (HP:0100842)2.74518072
17Clubbing of toes (HP:0100760)2.74315768
18Bifid tongue (HP:0010297)2.72014165
19Increased hepatocellular lipid droplets (HP:0006565)2.70919033
20Nephronophthisis (HP:0000090)2.70286820
21Neonatal hypoglycemia (HP:0001998)2.70081662
22Ectopic kidney (HP:0000086)2.69661357
23Prostate neoplasm (HP:0100787)2.66359231
24Congenital primary aphakia (HP:0007707)2.60780314
25Meckel diverticulum (HP:0002245)2.59602122
26Abnormality of the ileum (HP:0001549)2.58363180
27Abnormality of chromosome stability (HP:0003220)2.53024039
28Gait imbalance (HP:0002141)2.53000017
29Oligodactyly (hands) (HP:0001180)2.49411444
30Type 2 muscle fiber atrophy (HP:0003554)2.49217049
31Lipid accumulation in hepatocytes (HP:0006561)2.45641236
32Pancreatic cysts (HP:0001737)2.45613487
33Abnormality of the renal medulla (HP:0100957)2.44316411
34Parakeratosis (HP:0001036)2.40728878
35Abnormal biliary tract physiology (HP:0012439)2.36268161
36Bile duct proliferation (HP:0001408)2.36268161
37Hyperglycinemia (HP:0002154)2.35734947
38Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35364587
39Dynein arm defect of respiratory motile cilia (HP:0012255)2.34500221
40Absent/shortened dynein arms (HP:0200106)2.34500221
41Genital tract atresia (HP:0001827)2.34487803
42Asplenia (HP:0001746)2.33121319
43Renal cortical cysts (HP:0000803)2.32554207
44Vaginal atresia (HP:0000148)2.31987136
45Acute necrotizing encephalopathy (HP:0006965)2.31070272
46Acute encephalopathy (HP:0006846)2.26409584
47Duplication of thumb phalanx (HP:0009942)2.25775996
48Pancreatic fibrosis (HP:0100732)2.24622627
49Papillary thyroid carcinoma (HP:0002895)2.24357891
50Optic nerve hypoplasia (HP:0000609)2.23926479
51Anencephaly (HP:0002323)2.23274171
52Abnormality of the prostate (HP:0008775)2.22998659
53Methylmalonic acidemia (HP:0002912)2.20094246
54Cerebral palsy (HP:0100021)2.19909797
55Abnormal hair whorl (HP:0010721)2.19726479
56Reticulocytopenia (HP:0001896)2.19194352
57Short tibia (HP:0005736)2.18761321
58Hypothermia (HP:0002045)2.18343673
59Anophthalmia (HP:0000528)2.17697901
60Unilateral renal agenesis (HP:0000122)2.15337370
61Congenital sensorineural hearing impairment (HP:0008527)2.15171280
62Fair hair (HP:0002286)2.13988073
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.12830196
64Fibular hypoplasia (HP:0003038)2.11160840
65Abnormal lung lobation (HP:0002101)2.10944091
66Muscle fiber atrophy (HP:0100295)2.09866924
67Abnormal respiratory motile cilium morphology (HP:0005938)2.09305689
68Abnormal respiratory epithelium morphology (HP:0012253)2.09305689
69Chronic hepatic failure (HP:0100626)2.08561133
70Myelodysplasia (HP:0002863)2.07623084
71True hermaphroditism (HP:0010459)2.07614211
72Poor coordination (HP:0002370)2.07106969
73Sloping forehead (HP:0000340)2.06445891
74Upper limb muscle weakness (HP:0003484)2.05937278
75Postaxial foot polydactyly (HP:0001830)2.05786475
76Chronic mucocutaneous candidiasis (HP:0002728)2.05530646
77Recurrent cutaneous fungal infections (HP:0011370)2.05530646
78Cheilitis (HP:0100825)2.05477703
79Chronic diarrhea (HP:0002028)2.04703420
80Mitochondrial inheritance (HP:0001427)2.04352464
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.04021206
82Absent eyebrow (HP:0002223)2.03303966
83Small hand (HP:0200055)2.02232720
84Decreased central vision (HP:0007663)2.00589413
85Progressive macrocephaly (HP:0004481)1.97799163
863-Methylglutaconic aciduria (HP:0003535)1.97198404
87Increased CSF lactate (HP:0002490)1.96887906
88Stenosis of the external auditory canal (HP:0000402)1.95885147
89Bone marrow hypocellularity (HP:0005528)1.95491315
90Supernumerary spleens (HP:0009799)1.93266470
91Gastrointestinal atresia (HP:0002589)1.92904205
92Rectovaginal fistula (HP:0000143)1.92858926
93Rectal fistula (HP:0100590)1.92858926
94Abnormal ciliary motility (HP:0012262)1.92769509
95Anomalous pulmonary venous return (HP:0010772)1.92546226
96Triphalangeal thumb (HP:0001199)1.91206267
97Abnormality of the carotid arteries (HP:0005344)1.90530850
98B lymphocytopenia (HP:0010976)1.89644795
99Protruding tongue (HP:0010808)1.89189403
100Patellar aplasia (HP:0006443)1.89072121
101Postaxial hand polydactyly (HP:0001162)1.88483403
102Absent septum pellucidum (HP:0001331)1.88482700
103Morphological abnormality of the inner ear (HP:0011390)1.88417893
104Hypergonadotropic hypogonadism (HP:0000815)1.88379694
105Specific learning disability (HP:0001328)1.88256145
106Hypoplastic pelvis (HP:0008839)1.88246736
107Aplasia cutis congenita (HP:0001057)1.87922087
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.87858438
109Oculomotor apraxia (HP:0000657)1.87686369
110Abnormality of the duodenum (HP:0002246)1.87498043
111Congenital stationary night blindness (HP:0007642)1.86887662
112Abnormal number of erythroid precursors (HP:0012131)1.86442966
113Homocystinuria (HP:0002156)1.84610605
114Abnormality of homocysteine metabolism (HP:0010919)1.84610605
115Renal dysplasia (HP:0000110)1.83935873
116Absent rod-and cone-mediated responses on ERG (HP:0007688)1.83786480
117Male pseudohermaphroditism (HP:0000037)1.83758905
118Nephroblastoma (Wilms tumor) (HP:0002667)1.83517227
119Abnormal mitochondria in muscle tissue (HP:0008316)1.81816320
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81269739
121Abnormality of cells of the erythroid lineage (HP:0012130)1.81235391
122Oligohydramnios (HP:0001562)1.80394886
123Abnormality of the intervertebral disk (HP:0005108)1.80200519
124Thyroid-stimulating hormone excess (HP:0002925)1.79948880
125Growth hormone deficiency (HP:0000824)1.79604849
126Hypoplasia of the fovea (HP:0007750)1.79224131
127Aplasia/Hypoplasia of the fovea (HP:0008060)1.79224131
128Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78727251
129Hepatoblastoma (HP:0002884)1.78251612
130Median cleft lip (HP:0000161)1.77555710
131Prolonged partial thromboplastin time (HP:0003645)1.77405465
132Aplastic anemia (HP:0001915)1.77234045
133Preaxial hand polydactyly (HP:0001177)1.77064944
134Esophageal atresia (HP:0002032)1.76708604
135Sclerocornea (HP:0000647)1.76518172
136Renal Fanconi syndrome (HP:0001994)1.76309047
137Abnormality of alanine metabolism (HP:0010916)1.76216674
138Hyperalaninemia (HP:0003348)1.76216674
139Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76216674
140Molar tooth sign on MRI (HP:0002419)1.75783709
141Abnormality of midbrain morphology (HP:0002418)1.75783709
142Abnormality of the renal cortex (HP:0011035)1.75470745
143Osteomalacia (HP:0002749)1.75281135
144Conical tooth (HP:0000698)1.74608608
145Ectropion (HP:0000656)1.74486261
146Small intestinal stenosis (HP:0012848)1.73369278
147Duodenal stenosis (HP:0100867)1.73369278
148Febrile seizures (HP:0002373)1.72147157
149Glioma (HP:0009733)1.70719649
150Chronic otitis media (HP:0000389)1.69282045
151Narrow forehead (HP:0000341)1.69225493
152Intestinal atresia (HP:0011100)1.69090183
153Embryonal renal neoplasm (HP:0011794)1.68999340
154Oligodactyly (HP:0012165)1.68777666
155Astigmatism (HP:0000483)1.68577656
156Abolished electroretinogram (ERG) (HP:0000550)1.68348869
157Maternal diabetes (HP:0009800)1.68347167
158Pendular nystagmus (HP:0012043)1.68266649
159Aplasia/Hypoplasia of the fibula (HP:0006492)1.67638773
160Abnormality of the septum pellucidum (HP:0007375)1.67636145
16111 pairs of ribs (HP:0000878)1.67368881
162Congenital, generalized hypertrichosis (HP:0004540)1.67293402
163Tented upper lip vermilion (HP:0010804)1.67147665
164Premature graying of hair (HP:0002216)1.66908499
165Joint hemorrhage (HP:0005261)1.66353595
166Abnormality of the labia minora (HP:0012880)1.65965807
167Abnormality of dental color (HP:0011073)1.65463405
168Generalized hypopigmentation of hair (HP:0011358)1.65300951
169Diastasis recti (HP:0001540)1.64441060
170Aplasia/Hypoplasia of the patella (HP:0006498)1.64317782
171Aplasia/hypoplasia of the uterus (HP:0008684)1.64183610
172Drooling (HP:0002307)1.64058823
173Neoplasm of the adrenal cortex (HP:0100641)1.63645535
174Medulloblastoma (HP:0002885)1.62375436
175Prominent nasal bridge (HP:0000426)1.62263292
176Missing ribs (HP:0000921)1.61653591

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK164.84591582
2PNCK4.04411433
3NME23.64854558
4SIK33.55298018
5CASK3.23860958
6TNIK3.10680801
7NUAK12.85823450
8ZAK2.56084846
9GRK72.17059929
10EIF2AK22.04305501
11CDK82.01538651
12MST41.92422696
13TRIM281.88898929
14MAP4K21.85869709
15MAP3K41.84461295
16AKT31.82295396
17INSRR1.79731727
18LATS11.76411087
19GRK11.75264104
20MKNK21.73489658
21TXK1.72781530
22CAMK1G1.70827735
23EIF2AK31.68297848
24SIK21.67344794
25IRAK41.65580048
26SRPK11.64902296
27MAPK131.63801349
28ACVR1B1.56719819
29TGFBR21.55886476
30MAP3K141.53880066
31BLK1.53668618
32TAF11.52059527
33PRPF4B1.46376718
34IRAK31.43639068
35BCR1.40226420
36TSSK61.39685792
37CSNK1G11.38136011
38YES11.38079723
39MAP2K71.37137538
40BRD41.32849376
41VRK11.28084393
42CDC71.27136492
43ADRBK21.25074101
44BMPR1B1.23187867
45PBK1.20785592
46WEE11.20607685
47STK31.16602038
48MKNK11.15660858
49MUSK1.13842321
50PASK1.13126264
51ATR1.10460782
52DYRK31.09810799
53TEC1.09101205
54CDK31.06844075
55KIT1.06739602
56EPHA21.06736873
57CAMK1D1.03545370
58PLK41.02958496
59STK38L1.00959264
60PLK20.99305890
61CAMKK20.98148625
62BRAF0.96666827
63CCNB10.95829322
64BTK0.95659263
65MAPK150.95270637
66BRSK20.93776033
67CLK10.93039263
68TAOK20.93014537
69EIF2AK10.92351787
70SGK20.91918666
71VRK20.91606509
72PAK30.91265905
73CSNK1G30.89569810
74CSNK1G20.85921631
75BMPR20.75513452
76CDK70.74999153
77CSNK1A1L0.74560157
78IKBKB0.74377922
79NEK10.72970857
80NTRK30.72901549
81AURKB0.71051145
82ERBB30.70658402
83TTK0.70316575
84IRAK10.69516317
85BUB10.67026929
86BRSK10.66219199
87MARK30.65212869
88MAP3K60.65107761
89TGFBR10.64818636
90LYN0.62952850
91MAP3K120.62627456
92TNK20.61858523
93SIK10.61324713
94MARK10.60428334
95RPS6KA50.59709170
96NEK60.59026021
97CSF1R0.58829214
98NLK0.58769846
99PINK10.58023951
100DYRK20.57659831
101WNK30.57639984
102PLK30.57284916
103PRKCG0.57098782
104TAOK30.57003379
105RPS6KA40.56310042
106CHUK0.54427824
107MAP2K40.54264754
108STK40.50936424
109FRK0.50760191
110PIM10.50249531
111HCK0.49944254
112IKBKE0.47802678
113SYK0.47284369
114PLK10.47089119
115PKN10.46835813
116ATM0.46778116
117EPHA40.44966089
118FGFR20.44874411
119CDK120.44276427
120FGFR10.43918907
121CHEK20.43073103
122NEK90.42806206
123CDK190.42687426
124PIK3CG0.42616046
125GRK50.42259596
126SGK30.41949241
127JAK30.41744435
128CHEK10.41235273
129OXSR10.40817453
130NME10.39212434
131CSNK2A10.37857342
132CSNK1E0.37809808
133TYK20.36448752
134TLK10.35865062
135RPS6KB10.35648898
136RPS6KC10.35513822
137RPS6KL10.35513822
138PRKD30.34862448
139DYRK1A0.34818053
140CAMK10.34763658
141CDK90.34321243
142STK240.34247258
143MINK10.34027038
144CSNK2A20.33199134
145PRKCE0.32895277
146TIE10.32817952
147NTRK20.31279862
148AURKA0.31267024
149SGK2230.29881673
150CAMK40.29731909
151CSNK1A10.28764236
152PRKACB0.28759957

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034603.66957174
2Homologous recombination_Homo sapiens_hsa034403.17394707
3Oxidative phosphorylation_Homo sapiens_hsa001902.89828550
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.77847399
5DNA replication_Homo sapiens_hsa030302.57793166
6Non-homologous end-joining_Homo sapiens_hsa034502.48083263
7Parkinsons disease_Homo sapiens_hsa050122.47428934
8Mismatch repair_Homo sapiens_hsa034302.44586980
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.42439646
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.36987579
11Propanoate metabolism_Homo sapiens_hsa006402.31176995
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23825802
13Base excision repair_Homo sapiens_hsa034102.13022969
14Basal transcription factors_Homo sapiens_hsa030222.08895932
15RNA polymerase_Homo sapiens_hsa030201.96394854
16Primary immunodeficiency_Homo sapiens_hsa053401.93319152
17Huntingtons disease_Homo sapiens_hsa050161.90214775
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85127321
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83960866
20Nucleotide excision repair_Homo sapiens_hsa034201.83939474
21RNA degradation_Homo sapiens_hsa030181.78107420
22Pyrimidine metabolism_Homo sapiens_hsa002401.76217557
23Other glycan degradation_Homo sapiens_hsa005111.75935842
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.75889378
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.75553941
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70941785
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.66376384
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.65860989
29Fatty acid elongation_Homo sapiens_hsa000621.65740878
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63794459
31Allograft rejection_Homo sapiens_hsa053301.61566082
32Spliceosome_Homo sapiens_hsa030401.59550964
33Butanoate metabolism_Homo sapiens_hsa006501.57362953
34Sphingolipid metabolism_Homo sapiens_hsa006001.55839363
35One carbon pool by folate_Homo sapiens_hsa006701.55225634
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54598379
37Phototransduction_Homo sapiens_hsa047441.52910932
38Autoimmune thyroid disease_Homo sapiens_hsa053201.51504615
39Selenocompound metabolism_Homo sapiens_hsa004501.51426869
40Hematopoietic cell lineage_Homo sapiens_hsa046401.43928420
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43219866
42Alzheimers disease_Homo sapiens_hsa050101.37635779
43Circadian rhythm_Homo sapiens_hsa047101.37379469
44Purine metabolism_Homo sapiens_hsa002301.34651681
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.33704608
46Cell cycle_Homo sapiens_hsa041101.27333727
47Arachidonic acid metabolism_Homo sapiens_hsa005901.25598366
48Asthma_Homo sapiens_hsa053101.23407658
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.20985689
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20052087
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.15323360
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.12948532
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.12155176
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11754058
55Primary bile acid biosynthesis_Homo sapiens_hsa001201.11186042
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10154095
57Nitrogen metabolism_Homo sapiens_hsa009101.09745946
58Transcriptional misregulation in cancer_Homo sapiens_hsa052021.09577761
59Herpes simplex infection_Homo sapiens_hsa051681.08906711
60Protein export_Homo sapiens_hsa030601.05250057
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.03834962
62Folate biosynthesis_Homo sapiens_hsa007901.03690917
63Measles_Homo sapiens_hsa051621.02781079
64Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02443848
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01569260
66Vitamin B6 metabolism_Homo sapiens_hsa007501.00807420
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00666385
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.97908572
69Nicotine addiction_Homo sapiens_hsa050330.97641285
70RNA transport_Homo sapiens_hsa030130.96069037
71Graft-versus-host disease_Homo sapiens_hsa053320.95350583
72Pyruvate metabolism_Homo sapiens_hsa006200.95006138
73Collecting duct acid secretion_Homo sapiens_hsa049660.94622817
74p53 signaling pathway_Homo sapiens_hsa041150.92816437
75Ether lipid metabolism_Homo sapiens_hsa005650.92651379
76Oocyte meiosis_Homo sapiens_hsa041140.92087813
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90309002
78Linoleic acid metabolism_Homo sapiens_hsa005910.89977661
79Basal cell carcinoma_Homo sapiens_hsa052170.87898863
80ABC transporters_Homo sapiens_hsa020100.86886329
81Cardiac muscle contraction_Homo sapiens_hsa042600.86248328
82Fatty acid metabolism_Homo sapiens_hsa012120.85888023
83Regulation of autophagy_Homo sapiens_hsa041400.84739949
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82543680
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81950789
86mRNA surveillance pathway_Homo sapiens_hsa030150.81686463
87Lysine degradation_Homo sapiens_hsa003100.80763214
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80753644
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79940845
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79684216
91Hedgehog signaling pathway_Homo sapiens_hsa043400.79008349
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.74779502
93Leishmaniasis_Homo sapiens_hsa051400.74725783
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73498871
95Taste transduction_Homo sapiens_hsa047420.72779359
96Type I diabetes mellitus_Homo sapiens_hsa049400.72252724
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70599710
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63925805
99Serotonergic synapse_Homo sapiens_hsa047260.63745681
100beta-Alanine metabolism_Homo sapiens_hsa004100.63504236
101Tryptophan metabolism_Homo sapiens_hsa003800.62195660
102Wnt signaling pathway_Homo sapiens_hsa043100.61328104
103Ribosome_Homo sapiens_hsa030100.59435827
104TGF-beta signaling pathway_Homo sapiens_hsa043500.58943580
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55596415
106Vitamin digestion and absorption_Homo sapiens_hsa049770.54874981
107Staphylococcus aureus infection_Homo sapiens_hsa051500.52733553
108Systemic lupus erythematosus_Homo sapiens_hsa053220.52255955
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50881217
110Retinol metabolism_Homo sapiens_hsa008300.49962792
111Hippo signaling pathway_Homo sapiens_hsa043900.48259783
112Glutathione metabolism_Homo sapiens_hsa004800.47906929
113Alcoholism_Homo sapiens_hsa050340.47614072
114Epstein-Barr virus infection_Homo sapiens_hsa051690.43489960
115African trypanosomiasis_Homo sapiens_hsa051430.41186777
116Influenza A_Homo sapiens_hsa051640.40639372
117Calcium signaling pathway_Homo sapiens_hsa040200.39596378
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39513863
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38836230
120Fatty acid degradation_Homo sapiens_hsa000710.38592320
121Rheumatoid arthritis_Homo sapiens_hsa053230.37852614
122Olfactory transduction_Homo sapiens_hsa047400.37436086
123Axon guidance_Homo sapiens_hsa043600.35620153
124Notch signaling pathway_Homo sapiens_hsa043300.35221865
125FoxO signaling pathway_Homo sapiens_hsa040680.33564813
126Ovarian steroidogenesis_Homo sapiens_hsa049130.32495139
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.31629292
128Peroxisome_Homo sapiens_hsa041460.31109909
129Chemical carcinogenesis_Homo sapiens_hsa052040.30644345
130HTLV-I infection_Homo sapiens_hsa051660.30579150
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.30181657
132B cell receptor signaling pathway_Homo sapiens_hsa046620.28693054
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.27279881
134Metabolic pathways_Homo sapiens_hsa011000.26769503
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26045350
136Proteasome_Homo sapiens_hsa030500.26001063
137Morphine addiction_Homo sapiens_hsa050320.25521727
138Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25311552
139Tyrosine metabolism_Homo sapiens_hsa003500.25140927
140Steroid biosynthesis_Homo sapiens_hsa001000.22730459
141GABAergic synapse_Homo sapiens_hsa047270.22107375
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.21343998
143Arginine and proline metabolism_Homo sapiens_hsa003300.20385538
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20144634
145Phenylalanine metabolism_Homo sapiens_hsa003600.19739540
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19474043
147Dorso-ventral axis formation_Homo sapiens_hsa043200.19461847
148Long-term depression_Homo sapiens_hsa047300.19455164
149Caffeine metabolism_Homo sapiens_hsa002320.18215586
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.17400235
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.14906745

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