AASDHPPT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is similar to Saccharomyces cerevisiae LYS5, which is required for the activation of the alpha-aminoadipate dehydrogenase in the biosynthetic pathway of lysine. Yeast alpha-aminoadipate dehydrogenase converts alpha-biosynthetic-aminoadipate semialdehyde to alpha-aminoadipate. It has been suggested that defects in the human gene result in pipecolic acidemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.48396565
2ribosomal small subunit assembly (GO:0000028)4.48126188
3pyrimidine nucleobase catabolic process (GO:0006208)4.47237030
4cullin deneddylation (GO:0010388)4.36144476
5DNA double-strand break processing (GO:0000729)4.30515198
6L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.16835719
7ribosomal large subunit biogenesis (GO:0042273)4.14124812
8protein deneddylation (GO:0000338)4.09747445
9purine nucleobase biosynthetic process (GO:0009113)4.04743594
10presynaptic membrane assembly (GO:0097105)3.98214356
112-deoxyribonucleotide biosynthetic process (GO:0009265)3.89937272
12deoxyribose phosphate biosynthetic process (GO:0046385)3.89937272
13nucleobase biosynthetic process (GO:0046112)3.87930618
14maturation of 5.8S rRNA (GO:0000460)3.87594913
15maturation of SSU-rRNA (GO:0030490)3.85634675
16deoxyribonucleotide biosynthetic process (GO:0009263)3.85347134
17proteasome assembly (GO:0043248)3.81154930
18ribosome biogenesis (GO:0042254)3.76871463
19ribonucleoprotein complex biogenesis (GO:0022613)3.75974915
20CENP-A containing nucleosome assembly (GO:0034080)3.75806753
21chromatin remodeling at centromere (GO:0031055)3.69638217
22presynaptic membrane organization (GO:0097090)3.67740251
23neuron cell-cell adhesion (GO:0007158)3.65982593
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.64620642
25formation of translation preinitiation complex (GO:0001731)3.64620297
26amino acid salvage (GO:0043102)3.63797080
27L-methionine salvage (GO:0071267)3.63797080
28L-methionine biosynthetic process (GO:0071265)3.63797080
29telomere maintenance via semi-conservative replication (GO:0032201)3.61543486
30nucleobase catabolic process (GO:0046113)3.58389905
31spliceosomal snRNP assembly (GO:0000387)3.56191378
32mitochondrial respiratory chain complex I assembly (GO:0032981)3.52071250
33NADH dehydrogenase complex assembly (GO:0010257)3.52071250
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52071250
35rRNA processing (GO:0006364)3.51942471
36translational termination (GO:0006415)3.50583198
37DNA strand elongation involved in DNA replication (GO:0006271)3.50454647
38sperm-egg recognition (GO:0035036)3.48542116
39ribosomal small subunit biogenesis (GO:0042274)3.48367493
40DNA strand elongation (GO:0022616)3.46738297
41establishment of integrated proviral latency (GO:0075713)3.42868845
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.42830605
43viral transcription (GO:0019083)3.41181833
44DNA replication initiation (GO:0006270)3.40769346
45cellular component biogenesis (GO:0044085)3.40201729
46kinetochore organization (GO:0051383)3.40189631
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.36795842
48termination of RNA polymerase III transcription (GO:0006386)3.36795842
49rRNA metabolic process (GO:0016072)3.36255672
50transcription elongation from RNA polymerase I promoter (GO:0006362)3.35953623
51termination of RNA polymerase I transcription (GO:0006363)3.34056689
52DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31040574
53histone exchange (GO:0043486)3.30952277
54kinetochore assembly (GO:0051382)3.30902124
55regulation of mitochondrial translation (GO:0070129)3.30256199
567-methylguanosine mRNA capping (GO:0006370)3.29638756
57negative regulation of ligase activity (GO:0051352)3.29367830
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.29367830
59transcription from RNA polymerase I promoter (GO:0006360)3.28530763
60pseudouridine synthesis (GO:0001522)3.28198974
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.27936290
62regulation of cellular amino acid metabolic process (GO:0006521)3.27744853
63telomere maintenance via recombination (GO:0000722)3.27095094
64intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26131344
65signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26131344
667-methylguanosine RNA capping (GO:0009452)3.25758043
67RNA capping (GO:0036260)3.25758043
68rRNA modification (GO:0000154)3.25454871
69establishment of protein localization to mitochondrial membrane (GO:0090151)3.25437716
70mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.24912556
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.23994889
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.23994889
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.23994889
74mitotic metaphase plate congression (GO:0007080)3.23530103
75binding of sperm to zona pellucida (GO:0007339)3.20534877
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.20365034
77translation (GO:0006412)3.20270830
78postsynaptic membrane organization (GO:0001941)3.19824636
79transcription-coupled nucleotide-excision repair (GO:0006283)3.19299524
80deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.19149859
81protein localization to synapse (GO:0035418)3.18816242
82DNA replication-dependent nucleosome organization (GO:0034723)3.18195616
83DNA replication-dependent nucleosome assembly (GO:0006335)3.18195616
84viral mRNA export from host cell nucleus (GO:0046784)3.17463965
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.16578284
86cotranslational protein targeting to membrane (GO:0006613)3.16525958
87protein targeting to mitochondrion (GO:0006626)3.14036876
88DNA damage response, detection of DNA damage (GO:0042769)3.12991676
89signal transduction involved in DNA damage checkpoint (GO:0072422)3.12689752
90signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12689752
91translational elongation (GO:0006414)3.12494653
92nucleotide-excision repair, DNA gap filling (GO:0006297)3.11090803
93establishment of protein localization to mitochondrion (GO:0072655)3.09858788
94transcription initiation from RNA polymerase I promoter (GO:0006361)3.09346795
95protein targeting to ER (GO:0045047)3.09063076
96signal transduction involved in cell cycle checkpoint (GO:0072395)3.08296855
97oxidative phosphorylation (GO:0006119)3.08207170
98positive regulation of mitochondrial fission (GO:0090141)3.07453466
99synaptic vesicle maturation (GO:0016188)3.06910615
100telomere maintenance via telomere lengthening (GO:0010833)3.06031207
101translational initiation (GO:0006413)3.05865474
102DNA replication-independent nucleosome assembly (GO:0006336)3.05277650
103DNA replication-independent nucleosome organization (GO:0034724)3.05277650
104protein complex biogenesis (GO:0070271)3.04691126
105negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04237870
106establishment of mitochondrion localization (GO:0051654)3.04090831
107pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.03046124
108cell wall macromolecule metabolic process (GO:0044036)3.02755954
109cell wall macromolecule catabolic process (GO:0016998)3.02755954
110acrosome assembly (GO:0001675)3.02212046
111deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.02084609
112pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.01971439
113ribosome assembly (GO:0042255)3.01822027
114histone H2A acetylation (GO:0043968)2.93605200
115gamma-aminobutyric acid transport (GO:0015812)2.91431363
116negative regulation of DNA recombination (GO:0045910)2.89730533
117microtubule depolymerization (GO:0007019)2.87868325
118vocalization behavior (GO:0071625)2.87374950
119ribonucleoprotein complex disassembly (GO:0032988)2.83622573
120organelle disassembly (GO:1903008)2.81431607
121nonmotile primary cilium assembly (GO:0035058)2.80898586
122sequestering of actin monomers (GO:0042989)2.78887477
123regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78655093
124negative regulation of synaptic transmission, GABAergic (GO:0032229)2.67667072
125neurotransmitter-gated ion channel clustering (GO:0072578)2.65989745
126axonal fasciculation (GO:0007413)2.63557401
127chaperone-mediated protein transport (GO:0072321)2.61289176
128protein localization to cilium (GO:0061512)2.58988756
129limb bud formation (GO:0060174)2.57780672
130spermatid nucleus differentiation (GO:0007289)2.55465415
131neurofilament cytoskeleton organization (GO:0060052)2.54844274
132neuron recognition (GO:0008038)2.54380050
133protein-cofactor linkage (GO:0018065)2.53463945
134microtubule polymerization or depolymerization (GO:0031109)2.50972221
135glycosphingolipid biosynthetic process (GO:0006688)2.50843143
136regulation of synaptic vesicle exocytosis (GO:2000300)2.50762782
137synaptic vesicle exocytosis (GO:0016079)2.49835236
138glutamate secretion (GO:0014047)2.47401869
139anterograde axon cargo transport (GO:0008089)2.47202416
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.46994579
141regulation of feeding behavior (GO:0060259)2.46402682
142intraciliary transport (GO:0042073)2.44400212
143ionotropic glutamate receptor signaling pathway (GO:0035235)2.42204032
144regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.41479921
145protein neddylation (GO:0045116)2.41070609
146transmission of nerve impulse (GO:0019226)2.39885016
147G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39024555
148C4-dicarboxylate transport (GO:0015740)2.38331951
149neurotransmitter secretion (GO:0007269)2.38082697
150positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.37714076
151regulation of mitotic spindle checkpoint (GO:1903504)2.37190609
152regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37190609
153resolution of meiotic recombination intermediates (GO:0000712)2.36364961
154hippocampus development (GO:0021766)2.35921019
155synapse assembly (GO:0007416)2.35750007
156DNA integration (GO:0015074)2.34202491
157positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.32223785
158neural tube formation (GO:0001841)2.31893556
159positive regulation of synapse assembly (GO:0051965)2.31666176
160regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.30681990
161positive regulation of dendritic spine morphogenesis (GO:0061003)2.30138227
162glutamate receptor signaling pathway (GO:0007215)2.28992787
163regulation of development, heterochronic (GO:0040034)2.28882630
164cerebral cortex radially oriented cell migration (GO:0021799)2.28581988
165de novo posttranslational protein folding (GO:0051084)2.28525398
166de novo protein folding (GO:0006458)2.28437246
167retinal ganglion cell axon guidance (GO:0031290)2.26923921
168somatic diversification of immune receptors via somatic mutation (GO:0002566)2.26127991
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.26127991
170postreplication repair (GO:0006301)2.25971356
171regulation of dendritic spine morphogenesis (GO:0061001)2.25871636
172regulation of helicase activity (GO:0051095)2.24085497
173cytoskeleton-dependent intracellular transport (GO:0030705)2.22890396
174regulation of coenzyme metabolic process (GO:0051196)2.22701161
175regulation of cofactor metabolic process (GO:0051193)2.22701161
176fatty acid elongation (GO:0030497)2.22561573
177olfactory bulb development (GO:0021772)2.22490758
178protein K11-linked ubiquitination (GO:0070979)2.21795527
179synaptic transmission, glutamatergic (GO:0035249)2.21547401
180cholesterol biosynthetic process (GO:0006695)2.21447991
181regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21267403
182regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.20607532
183nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.20219882
184neuron-neuron synaptic transmission (GO:0007270)2.20061068
185double-strand break repair via nonhomologous end joining (GO:0006303)2.20017238
186non-recombinational repair (GO:0000726)2.20017238
187neuronal action potential propagation (GO:0019227)2.18854403
188behavioral response to nicotine (GO:0035095)2.18035935
189exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.17885019
190retinal cone cell development (GO:0046549)2.17740672
191DNA catabolic process, exonucleolytic (GO:0000738)2.16928306
192mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.16352165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.28588010
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.56525317
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.39670540
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.82309111
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.64995486
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.57567692
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07806142
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.07358224
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.06254828
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.02164679
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.98293264
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97229031
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97210656
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.95889235
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.94195399
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.84082367
17IGF1R_20145208_ChIP-Seq_DFB_Human2.80846343
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71129701
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67339099
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67255850
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64425530
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62261442
23TAF15_26573619_Chip-Seq_HEK293_Human2.57239257
24ZNF274_21170338_ChIP-Seq_K562_Hela2.55693477
25* VDR_23849224_ChIP-Seq_CD4+_Human2.51080237
26GBX2_23144817_ChIP-Seq_PC3_Human2.45295843
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43278282
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.40560363
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.34791995
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33718200
31* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31998912
32DCP1A_22483619_ChIP-Seq_HELA_Human2.30684962
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.24591086
34FOXP3_21729870_ChIP-Seq_TREG_Human2.23025538
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20527700
36SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17435759
37XRN2_22483619_ChIP-Seq_HELA_Human2.11983520
38SRF_21415370_ChIP-Seq_HL-1_Mouse2.10320242
39THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07585206
40ELK1_19687146_ChIP-ChIP_HELA_Human2.07192583
41EZH2_22144423_ChIP-Seq_EOC_Human2.05115249
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99841286
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98961041
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96395953
45* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.96323290
46TTF2_22483619_ChIP-Seq_HELA_Human1.93355361
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.89542752
48* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87146692
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.82824901
50GABP_19822575_ChIP-Seq_HepG2_Human1.79923832
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77987560
52P300_19829295_ChIP-Seq_ESCs_Human1.77361592
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76650944
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.75467873
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71955101
56* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.71704292
57* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.70561599
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.69387998
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64154979
60VDR_22108803_ChIP-Seq_LS180_Human1.63689435
61AR_21909140_ChIP-Seq_LNCAP_Human1.62677442
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62295238
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61003166
64POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58754562
65SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57569884
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.56386967
67* RNF2_27304074_Chip-Seq_NSC_Mouse1.50910838
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49023047
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.47642515
70FOXM1_23109430_ChIP-Seq_U2OS_Human1.47145499
71* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46656818
72CBX2_27304074_Chip-Seq_ESCs_Mouse1.46221576
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45997045
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44619236
75* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43876163
76KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42773408
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.42741375
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42636620
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.35147410
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34561448
81FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.34012276
82SMAD4_21799915_ChIP-Seq_A2780_Human1.33720075
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.33388172
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32749171
85SALL1_21062744_ChIP-ChIP_HESCs_Human1.29942209
86CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.28466964
87BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28280556
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27212316
89MYC_18940864_ChIP-ChIP_HL60_Human1.26434673
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25416460
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.25398040
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23314140
93SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22620630
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21616726
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21169376
96* REST_21632747_ChIP-Seq_MESCs_Mouse1.20930087
97EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20827691
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20762706
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20440213
100FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20412106
101NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20107714
102SMAD3_21741376_ChIP-Seq_EPCs_Human1.18546440
103* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15954669
104* REST_18959480_ChIP-ChIP_MESCs_Mouse1.14262742
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.12583186
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.12140381
107SOX2_16153702_ChIP-ChIP_HESCs_Human1.11250443
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11189707
109ER_23166858_ChIP-Seq_MCF-7_Human1.11035613
110TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10877175
111SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09268400
112* CBP_20019798_ChIP-Seq_JUKART_Human1.08273500
113* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08273500
114KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06800428
115ELK1_22589737_ChIP-Seq_MCF10A_Human1.05563044
116KDM5A_27292631_Chip-Seq_BREAST_Human1.04694115
117TP53_22573176_ChIP-Seq_HFKS_Human1.04540123
118JUN_21703547_ChIP-Seq_K562_Human1.03600631
119AR_25329375_ChIP-Seq_VCAP_Human1.03330881
120SOX9_26525672_Chip-Seq_HEART_Mouse1.02950803
121IRF1_19129219_ChIP-ChIP_H3396_Human1.02799564
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.01220937
123SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00922942
124STAT3_23295773_ChIP-Seq_U87_Human1.00240060
125EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99902829
126TAL1_26923725_Chip-Seq_HPCs_Mouse0.98932398
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.95541666
128AR_21572438_ChIP-Seq_LNCaP_Human0.95281089
129HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.94722528
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.93327911
131P53_22387025_ChIP-Seq_ESCs_Mouse0.92827869
132KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92184138
133TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.90565531
134CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90458578
135POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.89429713
136STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87334481
137HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.86181075
138SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84314878
139EWS_26573619_Chip-Seq_HEK293_Human0.84314509
140SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.84219365
141RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83442276
142* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82945924
143BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81421370
144E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79615416
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79579520
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.79280217
147ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78082036
148* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.78062135
149PCGF2_27294783_Chip-Seq_NPCs_Mouse0.78025463
150SOX17_20123909_ChIP-Seq_XEN_Mouse0.77189862
151* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76417672
152FUS_26573619_Chip-Seq_HEK293_Human0.76029312
153FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75903371
154* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.75589575
155CIITA_25753668_ChIP-Seq_RAJI_Human0.74819187
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74082307
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.71308394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis4.49763855
2MP0003693_abnormal_embryo_hatching4.44928544
3MP0008058_abnormal_DNA_repair4.22246278
4MP0010094_abnormal_chromosome_stability3.98054797
5MP0004957_abnormal_blastocyst_morpholog3.82637347
6MP0003880_abnormal_central_pattern3.64248210
7MP0009379_abnormal_foot_pigmentation3.42536758
8MP0008057_abnormal_DNA_replication2.94986076
9MP0009697_abnormal_copulation2.88967663
10MP0003111_abnormal_nucleus_morphology2.85742282
11MP0003186_abnormal_redox_activity2.82976390
12MP0003077_abnormal_cell_cycle2.76670320
13MP0008007_abnormal_cellular_replicative2.71679876
14MP0002822_catalepsy2.70435673
15MP0004270_analgesia2.56232328
16MP0004859_abnormal_synaptic_plasticity2.50852070
17MP0008877_abnormal_DNA_methylation2.40491864
18MP0008932_abnormal_embryonic_tissue2.32607592
19MP0005410_abnormal_fertilization2.29629788
20MP0003786_premature_aging2.26530756
21MP0006036_abnormal_mitochondrial_physio2.24734540
22MP0002132_abnormal_respiratory_system2.22731845
23MP0003122_maternal_imprinting2.17836845
24MP0003123_paternal_imprinting2.14397287
25MP0000778_abnormal_nervous_system2.08955938
26MP0002653_abnormal_ependyma_morphology2.00890069
27MP0005394_taste/olfaction_phenotype1.98172682
28MP0005499_abnormal_olfactory_system1.98172682
29MP0003635_abnormal_synaptic_transmissio1.95225088
30MP0005423_abnormal_somatic_nervous1.94632190
31MP0009046_muscle_twitch1.90996237
32MP0006276_abnormal_autonomic_nervous1.90971755
33MP0003787_abnormal_imprinting1.88319423
34MP0009745_abnormal_behavioral_response1.87075738
35MP0002736_abnormal_nociception_after1.85566590
36MP0003121_genomic_imprinting1.84450481
37MP0006072_abnormal_retinal_apoptosis1.84284186
38MP0005085_abnormal_gallbladder_physiolo1.81807675
39MP0003718_maternal_effect1.81742037
40MP0001764_abnormal_homeostasis1.81195227
41MP0002234_abnormal_pharynx_morphology1.78133745
42MP0006035_abnormal_mitochondrial_morpho1.75116123
43MP0001486_abnormal_startle_reflex1.72670709
44MP0001929_abnormal_gametogenesis1.70305925
45MP0006292_abnormal_olfactory_placode1.68527049
46MP0001968_abnormal_touch/_nociception1.68204768
47MP0002272_abnormal_nervous_system1.65513505
48MP0002210_abnormal_sex_determination1.65335060
49MP0001188_hyperpigmentation1.62727204
50MP0002063_abnormal_learning/memory/cond1.62292915
51MP0002064_seizures1.57632181
52MP0002734_abnormal_mechanical_nocicepti1.57062766
53MP0002735_abnormal_chemical_nociception1.56842511
54MP0000566_synostosis1.56533060
55MP0002572_abnormal_emotion/affect_behav1.53315454
56MP0005084_abnormal_gallbladder_morpholo1.51818397
57MP0002638_abnormal_pupillary_reflex1.50441560
58MP0003941_abnormal_skin_development1.49847627
59MP0005253_abnormal_eye_physiology1.46519762
60MP0003698_abnormal_male_reproductive1.46274243
61MP0005645_abnormal_hypothalamus_physiol1.44369898
62MP0001145_abnormal_male_reproductive1.44053551
63MP0008875_abnormal_xenobiotic_pharmacok1.42671917
64MP0005187_abnormal_penis_morphology1.41840771
65MP0002139_abnormal_hepatobiliary_system1.38500020
66MP0005266_abnormal_metabolism1.36648745
67MP0004811_abnormal_neuron_physiology1.35847313
68MP0002184_abnormal_innervation1.35737299
69MP0008995_early_reproductive_senescence1.33914722
70MP0000653_abnormal_sex_gland1.32710957
71MP0003656_abnormal_erythrocyte_physiolo1.29128835
72MP0000955_abnormal_spinal_cord1.26343517
73MP0003195_calcinosis1.24109090
74MP0004924_abnormal_behavior1.23355118
75MP0005386_behavior/neurological_phenoty1.23355118
76MP0003119_abnormal_digestive_system1.23125292
77MP0001730_embryonic_growth_arrest1.23104832
78MP0002557_abnormal_social/conspecific_i1.22527031
79MP0001293_anophthalmia1.22419780
80MP0000631_abnormal_neuroendocrine_gland1.21717962
81MP0002233_abnormal_nose_morphology1.20900015
82MP0004133_heterotaxia1.19572301
83MP0005365_abnormal_bile_salt1.19517194
84MP0003011_delayed_dark_adaptation1.19118686
85MP0000372_irregular_coat_pigmentation1.18809333
86MP0002160_abnormal_reproductive_system1.18143032
87MP0002067_abnormal_sensory_capabilities1.18007726
88MP0000350_abnormal_cell_proliferation1.17809716
89MP0002396_abnormal_hematopoietic_system1.15330889
90MP0002882_abnormal_neuron_morphology1.14698774
91MP0004215_abnormal_myocardial_fiber1.14047844
92MP0005551_abnormal_eye_electrophysiolog1.10734160
93MP0003646_muscle_fatigue1.09689873
94MP0003567_abnormal_fetal_cardiomyocyte1.09180694
95MP0003937_abnormal_limbs/digits/tail_de1.07658877
96MP0001119_abnormal_female_reproductive1.06244966
97MP0001970_abnormal_pain_threshold1.06238106
98MP0002163_abnormal_gland_morphology1.05837032
99MP0002938_white_spotting1.05461203
100MP0005389_reproductive_system_phenotype1.03553816
101MP0001984_abnormal_olfaction1.02657361
102MP0002733_abnormal_thermal_nociception1.02609935
103MP0001177_atelectasis1.01755982
104MP0002752_abnormal_somatic_nervous1.00784883
105MP0005075_abnormal_melanosome_morpholog0.99642402
106MP0005360_urolithiasis0.99446506
107MP0000049_abnormal_middle_ear0.99369819
108MP0003861_abnormal_nervous_system0.99032604
109MP0000358_abnormal_cell_content/0.98872522
110MP0000313_abnormal_cell_death0.98389144
111MP0002282_abnormal_trachea_morphology0.98120900
112MP0002152_abnormal_brain_morphology0.96160577
113MP0002009_preneoplasia0.93382009
114MP0002102_abnormal_ear_morphology0.93301415
115MP0005332_abnormal_amino_acid0.92474210
116MP0005408_hypopigmentation0.91911000
117MP0001919_abnormal_reproductive_system0.91585645
118MP0001299_abnormal_eye_distance/0.91199793
119MP0001905_abnormal_dopamine_level0.91156589
120MP0005391_vision/eye_phenotype0.91014680
121MP0000569_abnormal_digit_pigmentation0.90980301
122MP0002066_abnormal_motor_capabilities/c0.90375525
123MP0000647_abnormal_sebaceous_gland0.88752110
124MP0004145_abnormal_muscle_electrophysio0.87411206
125MP0001697_abnormal_embryo_size0.86916271
126MP0005376_homeostasis/metabolism_phenot0.86447010
127MP0008789_abnormal_olfactory_epithelium0.86056738
128MP0004142_abnormal_muscle_tone0.86012700
129MP0005380_embryogenesis_phenotype0.85893300
130MP0001672_abnormal_embryogenesis/_devel0.85893300
131MP0001440_abnormal_grooming_behavior0.84689959
132MP0000490_abnormal_crypts_of0.83791075
133MP0002161_abnormal_fertility/fecundity0.83670324
134MP0005248_abnormal_Harderian_gland0.82889850
135MP0003136_yellow_coat_color0.81964217
136MP0001502_abnormal_circadian_rhythm0.81096813
137MP0003890_abnormal_embryonic-extraembry0.80686868
138MP0001529_abnormal_vocalization0.80677954
139MP0002080_prenatal_lethality0.80119510
140MP0003385_abnormal_body_wall0.79751742
141MP0001542_abnormal_bone_strength0.78794594
142MP0002019_abnormal_tumor_incidence0.78264558
143MP0003315_abnormal_perineum_morphology0.76426065
144MP0002909_abnormal_adrenal_gland0.76297930
145MP0002069_abnormal_eating/drinking_beha0.75846842
146MP0001986_abnormal_taste_sensitivity0.73678280
147MP0003221_abnormal_cardiomyocyte_apopto0.72222838
148MP0002876_abnormal_thyroid_physiology0.71449605
149MP0004147_increased_porphyrin_level0.70756228
150MP0003984_embryonic_growth_retardation0.69692336
151MP0002751_abnormal_autonomic_nervous0.67070923
152MP0002277_abnormal_respiratory_mucosa0.66753034
153MP0003943_abnormal_hepatobiliary_system0.66285794
154MP0002088_abnormal_embryonic_growth/wei0.65798068
155MP0003763_abnormal_thymus_physiology0.64739469
156MP0005379_endocrine/exocrine_gland_phen0.64645478
157MP0005647_abnormal_sex_gland0.63877894
158MP0005636_abnormal_mineral_homeostasis0.63240850
159MP0002085_abnormal_embryonic_tissue0.62823936
160MP0005646_abnormal_pituitary_gland0.58836953
161MP0005319_abnormal_enzyme/_coenzyme0.58815896
162MP0001286_abnormal_eye_development0.58615877
163MP0009053_abnormal_anal_canal0.58515415
164MP0000516_abnormal_urinary_system0.53397047
165MP0005367_renal/urinary_system_phenotyp0.53397047
166MP0009765_abnormal_xenobiotic_induced0.52969811
167MP0002084_abnormal_developmental_patter0.52144786

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.10909137
2Birth length less than 3rd percentile (HP:0003561)3.86035275
3Abnormality of glycolysis (HP:0004366)3.79875000
4Increased serum pyruvate (HP:0003542)3.79875000
5Abnormal mitochondria in muscle tissue (HP:0008316)3.78838863
6Increased CSF lactate (HP:0002490)3.70243886
7Mitochondrial inheritance (HP:0001427)3.62477325
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.59193127
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.59193127
10Acute encephalopathy (HP:0006846)3.56622480
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.44045151
12Hepatocellular necrosis (HP:0001404)3.42852771
13Abnormality of the labia minora (HP:0012880)3.36227286
14Hepatic necrosis (HP:0002605)3.35010304
15Progressive macrocephaly (HP:0004481)3.26763618
16Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.23406598
17Abnormality of alanine metabolism (HP:0010916)3.23406598
18Hyperalaninemia (HP:0003348)3.23406598
19Oral leukoplakia (HP:0002745)3.19924196
20Increased serum lactate (HP:0002151)3.16245821
21Reticulocytopenia (HP:0001896)3.13675543
22Gait imbalance (HP:0002141)3.07028571
23Cerebral edema (HP:0002181)3.05400393
24Cortical dysplasia (HP:0002539)3.03251627
253-Methylglutaconic aciduria (HP:0003535)3.02533398
26Tongue fasciculations (HP:0001308)2.98397699
27Microvesicular hepatic steatosis (HP:0001414)2.93071993
28Lactic acidosis (HP:0003128)2.92574507
29Increased hepatocellular lipid droplets (HP:0006565)2.91252349
30Focal motor seizures (HP:0011153)2.85990524
31Abnormal spermatogenesis (HP:0008669)2.85478794
32Congenital primary aphakia (HP:0007707)2.84008112
33Lipid accumulation in hepatocytes (HP:0006561)2.83034773
34Abnormality of the anterior horn cell (HP:0006802)2.82496620
35Degeneration of anterior horn cells (HP:0002398)2.82496620
36Limb dystonia (HP:0002451)2.73881385
37Abnormality of cells of the erythroid lineage (HP:0012130)2.73039504
38Abnormal number of erythroid precursors (HP:0012131)2.72188085
39Nephrogenic diabetes insipidus (HP:0009806)2.70257386
40Exercise intolerance (HP:0003546)2.63452484
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.62843040
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.62843040
43Myokymia (HP:0002411)2.61026669
44Volvulus (HP:0002580)2.60860830
45Breast hypoplasia (HP:0003187)2.60416728
46Aplastic anemia (HP:0001915)2.59754607
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.57388635
48Atonic seizures (HP:0010819)2.55802051
49Drooling (HP:0002307)2.54525685
50Cerebral hypomyelination (HP:0006808)2.51960048
51Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.49246190
52Pancreatic fibrosis (HP:0100732)2.46317960
53Genital tract atresia (HP:0001827)2.44574162
54Irregular epiphyses (HP:0010582)2.44121087
55Muscle fibrillation (HP:0010546)2.43723829
56Vaginal atresia (HP:0000148)2.41699623
57Colon cancer (HP:0003003)2.40568748
58Abnormality of the corticospinal tract (HP:0002492)2.40040261
59Macrocytic anemia (HP:0001972)2.35462394
60Urinary urgency (HP:0000012)2.35418401
61Retinal dysplasia (HP:0007973)2.34157481
62Methylmalonic acidemia (HP:0002912)2.32202722
63Progressive external ophthalmoplegia (HP:0000590)2.30145625
64Supernumerary spleens (HP:0009799)2.25854032
6511 pairs of ribs (HP:0000878)2.25566240
66Lethargy (HP:0001254)2.24260846
67Excessive salivation (HP:0003781)2.23986463
68Lissencephaly (HP:0001339)2.23387984
69Rough bone trabeculation (HP:0100670)2.22421794
70Type I transferrin isoform profile (HP:0003642)2.21753704
71Facial cleft (HP:0002006)2.21287208
72Abnormality of serum amino acid levels (HP:0003112)2.20599696
73Focal seizures (HP:0007359)2.20548682
74Atrophy/Degeneration involving motor neurons (HP:0007373)2.19710972
75Amyotrophic lateral sclerosis (HP:0007354)2.19453135
76Intestinal atresia (HP:0011100)2.18515623
77Medulloblastoma (HP:0002885)2.17888815
78Abnormality of the preputium (HP:0100587)2.17284113
79Chromsome breakage (HP:0040012)2.16777662
80Azoospermia (HP:0000027)2.16182099
81Reduced antithrombin III activity (HP:0001976)2.15217552
82Specific learning disability (HP:0001328)2.14738574
83Selective tooth agenesis (HP:0001592)2.14584164
84Impaired vibration sensation in the lower limbs (HP:0002166)2.13081876
85Respiratory failure (HP:0002878)2.13025168
86Febrile seizures (HP:0002373)2.12882155
87Chromosomal breakage induced by crosslinking agents (HP:0003221)2.12868106
88Abnormality of pyrimidine metabolism (HP:0004353)2.05247203
89Abnormality of chromosome stability (HP:0003220)2.03929458
90Pancytopenia (HP:0001876)2.03012726
91Median cleft lip (HP:0000161)2.02488998
92Epileptic encephalopathy (HP:0200134)2.02383816
93Shoulder girdle muscle weakness (HP:0003547)2.02307227
94Oligodactyly (hands) (HP:0001180)2.01389939
95Poor suck (HP:0002033)2.01061763
96Hypobetalipoproteinemia (HP:0003563)2.00481433
97Optic disc pallor (HP:0000543)2.00438504
98Absent thumb (HP:0009777)1.99999638
99Horseshoe kidney (HP:0000085)1.99654255
100Respiratory difficulties (HP:0002880)1.99555951
101Abnormal lung lobation (HP:0002101)1.99359182
102Molar tooth sign on MRI (HP:0002419)1.99206547
103CNS demyelination (HP:0007305)1.98934239
104Renal Fanconi syndrome (HP:0001994)1.98284884
105Medial flaring of the eyebrow (HP:0010747)1.97503823
106True hermaphroditism (HP:0010459)1.96022521
107Neuroendocrine neoplasm (HP:0100634)1.95075593
108Short tibia (HP:0005736)1.94134872
109Leukodystrophy (HP:0002415)1.93528079
110Sparse eyelashes (HP:0000653)1.93520980
111Increased intramyocellular lipid droplets (HP:0012240)1.92677709
112Pheochromocytoma (HP:0002666)1.92112943
113Ependymoma (HP:0002888)1.92080124
114Abnormality of the astrocytes (HP:0100707)1.90503912
115Astrocytoma (HP:0009592)1.90503912
116Hyperglycinemia (HP:0002154)1.90492423
117Abnormal ciliary motility (HP:0012262)1.90479037
118Split foot (HP:0001839)1.90203380
119Abnormal trabecular bone morphology (HP:0100671)1.89758808
120Pallor (HP:0000980)1.89690504
121Premature graying of hair (HP:0002216)1.89620941
122Abnormal respiratory motile cilium physiology (HP:0012261)1.89373275
123Polyphagia (HP:0002591)1.89159558
124Abnormality of methionine metabolism (HP:0010901)1.88041817
125Nephronophthisis (HP:0000090)1.87564109
126Pancreatic cysts (HP:0001737)1.86984939
127Poor coordination (HP:0002370)1.85102416
128Absent radius (HP:0003974)1.83882814
129Generalized aminoaciduria (HP:0002909)1.83432168
130Spastic tetraplegia (HP:0002510)1.83335897
131Hypsarrhythmia (HP:0002521)1.82914380
132Carpal bone hypoplasia (HP:0001498)1.81846345
133Inability to walk (HP:0002540)1.81629064
134Microretrognathia (HP:0000308)1.81540639
135Triphalangeal thumb (HP:0001199)1.81294923
136Methylmalonic aciduria (HP:0012120)1.81236318
137Generalized tonic-clonic seizures (HP:0002069)1.80841275
138Glioma (HP:0009733)1.80392055
139Morphological abnormality of the pyramidal tract (HP:0002062)1.79515020
140Muscular hypotonia of the trunk (HP:0008936)1.79393409
141Meckel diverticulum (HP:0002245)1.78538181
142Epileptiform EEG discharges (HP:0011182)1.78438631
143Broad-based gait (HP:0002136)1.78125982
144Progressive inability to walk (HP:0002505)1.77963158
145Postaxial hand polydactyly (HP:0001162)1.77929445
146Optic nerve hypoplasia (HP:0000609)1.77836449
147EEG with generalized epileptiform discharges (HP:0011198)1.76869280
148Aplasia/Hypoplasia of the tibia (HP:0005772)1.76504542
149CNS hypomyelination (HP:0003429)1.76133680
150Papillary thyroid carcinoma (HP:0002895)1.76106020
151Abnormality of the metopic suture (HP:0005556)1.74944261
152Broad foot (HP:0001769)1.74933611
153Secondary amenorrhea (HP:0000869)1.73659081
154Abnormality of the ileum (HP:0001549)1.73617133
155Megaloblastic anemia (HP:0001889)1.72974639
156Hypothermia (HP:0002045)1.71776384
157Increased muscle lipid content (HP:0009058)1.71623845
158Pachygyria (HP:0001302)1.70879042
159Nephroblastoma (Wilms tumor) (HP:0002667)1.70705732
160Aplasia involving forearm bones (HP:0009822)1.70182714
161Absent forearm bone (HP:0003953)1.70182714
162Postnatal microcephaly (HP:0005484)1.69756262
163Renal cortical cysts (HP:0000803)1.69399827
164Dialeptic seizures (HP:0011146)1.69000818
165Abnormality of the musculature of the pelvis (HP:0001469)1.68763348
166Abnormality of the hip-girdle musculature (HP:0001445)1.68763348
167Abnormal hair whorl (HP:0010721)1.68566648
168Abnormality of midbrain morphology (HP:0002418)1.68428743
169Type II lissencephaly (HP:0007260)1.67960816
170Abnormality of the lower motor neuron (HP:0002366)1.67797274
171Rimmed vacuoles (HP:0003805)1.66724431
172Decreased testicular size (HP:0008734)1.66197276
173Scrotal hypoplasia (HP:0000046)1.64947954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.70119076
2BUB13.66043221
3STK163.62898126
4WEE13.51047926
5MARK13.26699527
6TRIM283.19751740
7MAP3K42.96177396
8SRPK12.63256366
9EIF2AK32.61838343
10WNK32.42364502
11MAP4K22.41943130
12BCKDK2.37586255
13PDK32.36708142
14PDK42.36708142
15VRK12.31116709
16NME22.27125263
17PBK2.16033178
18EPHA42.00944664
19CSNK1G21.99725555
20MAP3K121.98582268
21CCNB11.94373563
22TSSK61.90444416
23ZAK1.88221452
24BRSK21.80388418
25CDC71.79421017
26TTK1.76840275
27CSNK1A1L1.75389384
28MAPK131.71810419
29CSNK1G11.70618730
30CASK1.67946007
31MKNK11.64755899
32STK38L1.64245012
33PDK21.64076602
34PLK41.61530953
35PLK31.58034426
36MKNK21.52746260
37ACVR1B1.52366829
38MINK11.48227665
39PNCK1.47429928
40TLK11.46689773
41NME11.43615587
42NEK11.42722824
43MST41.38137574
44EIF2AK21.32013604
45PLK11.31654127
46DYRK31.29622483
47UHMK11.17938868
48ATR1.15088593
49PASK1.13672890
50BCR1.12292946
51AKT31.11282757
52TESK11.10605314
53TNIK1.09637086
54YES11.06620432
55RPS6KB21.05699980
56NTRK21.02202714
57TESK21.01975069
58CDK71.01437804
59AURKA1.00533599
60PRKCG0.99458417
61STK240.97660081
62MAP2K70.97013380
63PAK30.96814154
64AURKB0.96091798
65PAK60.91266629
66FRK0.90990999
67CHEK20.89448834
68PLK20.89136783
69MAP2K40.87970654
70PHKG20.86881391
71PHKG10.86881391
72BRSK10.81558475
73CDK140.81384151
74CDK80.80858039
75LIMK10.80823603
76CDK180.77914623
77NTRK30.77347003
78CSNK2A20.76893607
79PIM20.76176739
80NEK20.75054277
81SIK30.74357735
82FLT30.73574876
83DYRK20.72978963
84CSNK2A10.72234503
85NEK60.72156801
86BRAF0.70220838
87CAMKK20.69034822
88CDK150.68149649
89CAMK2A0.67815689
90CDK50.66582070
91CHEK10.66017170
92BMPR20.65303860
93PRKCE0.64916322
94CDK11A0.63685580
95EPHA30.59866791
96CAMK2B0.57669706
97STK40.57321301
98VRK20.57088158
99BRD40.56971721
100DYRK1A0.56663939
101PRPF4B0.56043700
102ATM0.55616804
103NEK90.54943921
104EPHA20.51944668
105CSNK1E0.51939701
106MYLK0.51128501
107PKN10.50254389
108KSR10.50152769
109BMPR1B0.49940441
110INSRR0.47724450
111CDK190.47188141
112STK390.45382017
113TAOK20.45341286
114OBSCN0.44726341
115DAPK20.44556652
116DAPK10.44553970
117PINK10.43308867
118MAP3K110.42446540
119TEC0.42307554
120CSNK1G30.41387125
121PIM10.40878128
122CSNK1D0.39821070
123CSNK1A10.39733383
124RPS6KA40.39134952
125KDR0.38925854
126RPS6KA50.38311900
127GRK10.37965640
128MAP3K140.37773403
129PRKCI0.37318781
130MAP2K60.37181269
131PRKACB0.36272744
132FGFR20.36174822
133PIK3CG0.36111586
134EPHB20.35514756
135TXK0.34785028
136ADRBK20.33875230
137MAP3K30.33770304
138TGFBR10.33550964
139SIK20.33132476
140CDK10.32343778
141ABL20.31430322
142ERBB30.30679284
143RPS6KB10.30301924
144MAP3K50.29766181
145CDK20.28772260
146CDK30.26801503
147OXSR10.26478880
148NUAK10.25810541
149PAK10.23974946
150PTK2B0.22512792

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.87628582
2Ribosome_Homo sapiens_hsa030103.56778894
3DNA replication_Homo sapiens_hsa030303.36949549
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35640683
5Mismatch repair_Homo sapiens_hsa034303.15867163
6RNA polymerase_Homo sapiens_hsa030202.94723768
7Nicotine addiction_Homo sapiens_hsa050332.91593239
8Homologous recombination_Homo sapiens_hsa034402.70768527
9Nucleotide excision repair_Homo sapiens_hsa034202.45957502
10Spliceosome_Homo sapiens_hsa030402.35216908
11Pyrimidine metabolism_Homo sapiens_hsa002402.31823072
12Oxidative phosphorylation_Homo sapiens_hsa001902.20848234
13RNA transport_Homo sapiens_hsa030132.20267254
14One carbon pool by folate_Homo sapiens_hsa006702.17079613
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16422620
16Basal transcription factors_Homo sapiens_hsa030222.12034732
17Protein export_Homo sapiens_hsa030602.07189089
18Parkinsons disease_Homo sapiens_hsa050122.05958310
19Base excision repair_Homo sapiens_hsa034102.00626282
20Fanconi anemia pathway_Homo sapiens_hsa034601.94793713
21Huntingtons disease_Homo sapiens_hsa050161.86790177
22RNA degradation_Homo sapiens_hsa030181.80677682
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.76118317
24GABAergic synapse_Homo sapiens_hsa047271.74229707
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70139499
26Synaptic vesicle cycle_Homo sapiens_hsa047211.65691054
27Non-homologous end-joining_Homo sapiens_hsa034501.64243293
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.54904252
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.45684259
30Cell cycle_Homo sapiens_hsa041101.45261398
31Propanoate metabolism_Homo sapiens_hsa006401.43699568
32Purine metabolism_Homo sapiens_hsa002301.39938629
33Pentose phosphate pathway_Homo sapiens_hsa000301.39123043
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.36636516
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.33056520
36Carbon metabolism_Homo sapiens_hsa012001.31378367
37Taste transduction_Homo sapiens_hsa047421.30456685
38Collecting duct acid secretion_Homo sapiens_hsa049661.29172496
39Biosynthesis of amino acids_Homo sapiens_hsa012301.28570101
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28462392
41Folate biosynthesis_Homo sapiens_hsa007901.27169219
42Pyruvate metabolism_Homo sapiens_hsa006201.26967952
43Dopaminergic synapse_Homo sapiens_hsa047281.25798969
44Alzheimers disease_Homo sapiens_hsa050101.21560463
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21400401
46Morphine addiction_Homo sapiens_hsa050321.21182904
47Glutamatergic synapse_Homo sapiens_hsa047241.15192091
48Circadian entrainment_Homo sapiens_hsa047131.15172494
49Glutathione metabolism_Homo sapiens_hsa004801.14137081
50Sulfur relay system_Homo sapiens_hsa041221.11382046
51Fatty acid elongation_Homo sapiens_hsa000621.10563599
52Vitamin B6 metabolism_Homo sapiens_hsa007501.10041561
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07994545
54Amphetamine addiction_Homo sapiens_hsa050311.04642613
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02486863
56Systemic lupus erythematosus_Homo sapiens_hsa053221.01775587
57* Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00996126
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.99466727
59Cocaine addiction_Homo sapiens_hsa050300.99397150
60Sulfur metabolism_Homo sapiens_hsa009200.96242241
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95957305
62Peroxisome_Homo sapiens_hsa041460.94917438
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.92863407
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92122542
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87955989
66Olfactory transduction_Homo sapiens_hsa047400.85807452
67Selenocompound metabolism_Homo sapiens_hsa004500.84925450
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84300403
69mRNA surveillance pathway_Homo sapiens_hsa030150.84107999
70Circadian rhythm_Homo sapiens_hsa047100.83768163
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.82745589
72Metabolic pathways_Homo sapiens_hsa011000.80992703
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80056361
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79673740
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78448429
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77804625
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77623483
78Vibrio cholerae infection_Homo sapiens_hsa051100.75297948
79p53 signaling pathway_Homo sapiens_hsa041150.74131840
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73945788
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73839940
82Chemical carcinogenesis_Homo sapiens_hsa052040.72133560
83Alcoholism_Homo sapiens_hsa050340.68723536
84Retinol metabolism_Homo sapiens_hsa008300.68098589
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.66991665
86Axon guidance_Homo sapiens_hsa043600.66898758
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61874212
88Epstein-Barr virus infection_Homo sapiens_hsa051690.61765320
89Insulin secretion_Homo sapiens_hsa049110.60526661
90Serotonergic synapse_Homo sapiens_hsa047260.58801638
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58755312
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58556817
93Hedgehog signaling pathway_Homo sapiens_hsa043400.58126439
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57297839
95Hippo signaling pathway_Homo sapiens_hsa043900.56923130
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.55866115
97Steroid biosynthesis_Homo sapiens_hsa001000.55415532
98Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54891748
99Fatty acid degradation_Homo sapiens_hsa000710.54605717
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50837493
101Gap junction_Homo sapiens_hsa045400.49320171
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49012497
103Renin-angiotensin system_Homo sapiens_hsa046140.45142525
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42309753
105Wnt signaling pathway_Homo sapiens_hsa043100.40743882
106Cardiac muscle contraction_Homo sapiens_hsa042600.39841223
107Butanoate metabolism_Homo sapiens_hsa006500.38976843
108Tyrosine metabolism_Homo sapiens_hsa003500.38005860
109Arachidonic acid metabolism_Homo sapiens_hsa005900.37871576
110Long-term depression_Homo sapiens_hsa047300.37540960
111beta-Alanine metabolism_Homo sapiens_hsa004100.37443801
112Fatty acid metabolism_Homo sapiens_hsa012120.36653245
113Phenylalanine metabolism_Homo sapiens_hsa003600.36222708
114Oocyte meiosis_Homo sapiens_hsa041140.35781342
115Cholinergic synapse_Homo sapiens_hsa047250.35574323
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35008160
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34856425
118Salivary secretion_Homo sapiens_hsa049700.34202378
119TGF-beta signaling pathway_Homo sapiens_hsa043500.33997543
120Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33753452
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33384731
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33138555
123Fructose and mannose metabolism_Homo sapiens_hsa000510.31606067
124Basal cell carcinoma_Homo sapiens_hsa052170.30366619
125Caffeine metabolism_Homo sapiens_hsa002320.29583606
126Maturity onset diabetes of the young_Homo sapiens_hsa049500.28990774
127Arginine and proline metabolism_Homo sapiens_hsa003300.26314925
128Galactose metabolism_Homo sapiens_hsa000520.25219103
129Tryptophan metabolism_Homo sapiens_hsa003800.25074122
130Starch and sucrose metabolism_Homo sapiens_hsa005000.23430198
131Viral carcinogenesis_Homo sapiens_hsa052030.22373522
132Phototransduction_Homo sapiens_hsa047440.20500450
133Vitamin digestion and absorption_Homo sapiens_hsa049770.20300043
134N-Glycan biosynthesis_Homo sapiens_hsa005100.19450386
135Regulation of autophagy_Homo sapiens_hsa041400.19295707
136Herpes simplex infection_Homo sapiens_hsa051680.19265143
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.19094399
138Legionellosis_Homo sapiens_hsa051340.18416377

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