AATF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.76668804
2maturation of SSU-rRNA (GO:0030490)4.60874584
3DNA deamination (GO:0045006)4.49822917
4DNA strand elongation involved in DNA replication (GO:0006271)4.46239599
5formation of translation preinitiation complex (GO:0001731)4.42182554
6DNA unwinding involved in DNA replication (GO:0006268)4.32568063
7DNA replication initiation (GO:0006270)4.28323729
8DNA strand elongation (GO:0022616)4.27420971
9nucleobase biosynthetic process (GO:0046112)4.25651339
10establishment of integrated proviral latency (GO:0075713)4.23006771
11telomere maintenance via semi-conservative replication (GO:0032201)4.13334851
12viral transcription (GO:0019083)4.06766135
13purine nucleobase biosynthetic process (GO:0009113)4.05761292
14ribosome assembly (GO:0042255)4.05622541
15translational termination (GO:0006415)4.01526634
16* ribosome biogenesis (GO:0042254)3.95693276
17ribosomal large subunit biogenesis (GO:0042273)3.93920182
18mitotic chromosome condensation (GO:0007076)3.89236896
19IMP biosynthetic process (GO:0006188)3.89140754
20* ribonucleoprotein complex biogenesis (GO:0022613)3.86610656
21pore complex assembly (GO:0046931)3.85477889
22folic acid-containing compound biosynthetic process (GO:0009396)3.82060696
23DNA replication checkpoint (GO:0000076)3.77809639
24protein localization to kinetochore (GO:0034501)3.77263002
25ribosomal small subunit biogenesis (GO:0042274)3.76010875
26translational elongation (GO:0006414)3.72279290
27translational initiation (GO:0006413)3.70596196
28establishment of viral latency (GO:0019043)3.68967093
29telomere maintenance via recombination (GO:0000722)3.68011497
30mitotic nuclear envelope disassembly (GO:0007077)3.65217597
31mitotic metaphase plate congression (GO:0007080)3.64694938
32rRNA processing (GO:0006364)3.59554063
33IMP metabolic process (GO:0046040)3.55054233
34mitotic sister chromatid segregation (GO:0000070)3.53521272
35mitotic recombination (GO:0006312)3.51498488
36nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51156332
37nuclear pore organization (GO:0006999)3.50239859
38regulation of translational termination (GO:0006449)3.49486394
39rRNA metabolic process (GO:0016072)3.49154216
40spliceosomal tri-snRNP complex assembly (GO:0000244)3.46127683
41DNA topological change (GO:0006265)3.43469350
42telomere maintenance via telomere lengthening (GO:0010833)3.42619361
43DNA replication-dependent nucleosome assembly (GO:0006335)3.41583333
44DNA replication-dependent nucleosome organization (GO:0034723)3.41583333
45pseudouridine synthesis (GO:0001522)3.41299106
46SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.40765674
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.38387535
48membrane disassembly (GO:0030397)3.37728704
49nuclear envelope disassembly (GO:0051081)3.37728704
50Golgi transport vesicle coating (GO:0048200)3.36726453
51COPI coating of Golgi vesicle (GO:0048205)3.36726453
52spliceosomal snRNP assembly (GO:0000387)3.35081605
53nuclear pore complex assembly (GO:0051292)3.34501457
54regulation of translational fidelity (GO:0006450)3.32424695
55cotranslational protein targeting to membrane (GO:0006613)3.28861453
56protein targeting to ER (GO:0045047)3.28831002
57chromatin remodeling at centromere (GO:0031055)3.26045317
58protein localization to chromosome, centromeric region (GO:0071459)3.25109987
59nucleobase-containing small molecule interconversion (GO:0015949)3.24327055
60metaphase plate congression (GO:0051310)3.23806828
61CENP-A containing nucleosome assembly (GO:0034080)3.23697535
62kinetochore organization (GO:0051383)3.20845972
63sister chromatid segregation (GO:0000819)3.19171723
64viral life cycle (GO:0019058)3.17005001
65nucleotide-excision repair, DNA gap filling (GO:0006297)3.14688351
66establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13191587
67DNA replication-independent nucleosome organization (GO:0034724)3.12898460
68DNA replication-independent nucleosome assembly (GO:0006336)3.12898460
69cellular protein complex disassembly (GO:0043624)3.12841815
70protein localization to endoplasmic reticulum (GO:0070972)3.09106256
71translesion synthesis (GO:0019985)3.06966919
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.05749329
73DNA duplex unwinding (GO:0032508)3.04806069
74DNA geometric change (GO:0032392)3.02679660
75maturation of 5.8S rRNA (GO:0000460)3.01524165
76kinetochore assembly (GO:0051382)3.01476318
77protein maturation by protein folding (GO:0022417)3.01326722
78proteasome assembly (GO:0043248)2.99317955
79negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95592825
80nuclear-transcribed mRNA catabolic process (GO:0000956)2.94574841
81tRNA methylation (GO:0030488)2.92351205
82translation (GO:0006412)2.92285327
83regulation of spindle organization (GO:0090224)2.91184430
84folic acid metabolic process (GO:0046655)2.89575661
85negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89476270
86negative regulation of ligase activity (GO:0051352)2.89476270
87peptidyl-arginine omega-N-methylation (GO:0035247)2.89458239
88protein complex disassembly (GO:0043241)2.88603335
89pentose-phosphate shunt (GO:0006098)2.87328701
90RNA splicing, via transesterification reactions (GO:0000375)2.86764237
91negative regulation of RNA splicing (GO:0033119)2.86676212
92mRNA splicing, via spliceosome (GO:0000398)2.85833651
93RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85833651
94tRNA aminoacylation for protein translation (GO:0006418)2.85616561
95* cellular component biogenesis (GO:0044085)2.84748897
96regulation of mitotic spindle organization (GO:0060236)2.84235049
97viral mRNA export from host cell nucleus (GO:0046784)2.83963427
98establishment of chromosome localization (GO:0051303)2.82955810
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.82354774
100negative regulation of mRNA processing (GO:0050686)2.82089885
101negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.81821495
102ncRNA processing (GO:0034470)2.81380460
103RNA catabolic process (GO:0006401)2.81248292
104telomere organization (GO:0032200)2.80353371
105telomere maintenance (GO:0000723)2.80336186
106mRNA catabolic process (GO:0006402)2.80303210
107rRNA modification (GO:0000154)2.80168032
108regulation of nuclear cell cycle DNA replication (GO:0033262)2.78556496
109somatic hypermutation of immunoglobulin genes (GO:0016446)2.78486085
110somatic diversification of immune receptors via somatic mutation (GO:0002566)2.78486085
111regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.77860333
112amino acid activation (GO:0043038)2.77676655
113tRNA aminoacylation (GO:0043039)2.77676655
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.77602950
115transcription-coupled nucleotide-excision repair (GO:0006283)2.76843066
116spliceosomal complex assembly (GO:0000245)2.76613913
117termination of RNA polymerase II transcription (GO:0006369)2.76547753
118ncRNA metabolic process (GO:0034660)2.75683948
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.75586662
120transcription from mitochondrial promoter (GO:0006390)2.75504392
121mitotic sister chromatid cohesion (GO:0007064)2.74572673
122protein export from nucleus (GO:0006611)2.73493812
123macromolecular complex disassembly (GO:0032984)2.73017019
124histone exchange (GO:0043486)2.73013698
125G1/S transition of mitotic cell cycle (GO:0000082)2.71858885
126cell cycle G1/S phase transition (GO:0044843)2.71858885
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71775134
128regulation of RNA export from nucleus (GO:0046831)2.70427705
129nuclear envelope reassembly (GO:0031468)2.66836744
130mitotic nuclear envelope reassembly (GO:0007084)2.66836744
131NADPH regeneration (GO:0006740)2.66443749
132negative regulation of mRNA metabolic process (GO:1903312)2.66345500
133nuclear envelope organization (GO:0006998)2.55526838
134DNA conformation change (GO:0071103)2.52482262
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.50626445
136double-strand break repair via nonhomologous end joining (GO:0006303)2.49967960
137non-recombinational repair (GO:0000726)2.49967960
138signal transduction involved in DNA damage checkpoint (GO:0072422)2.47091416
139signal transduction involved in DNA integrity checkpoint (GO:0072401)2.47091416
140rRNA transcription (GO:0009303)2.47012218
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.46646394
142intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.46559309
143signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.46559309
144heterochromatin organization (GO:0070828)2.46388456
145signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.43093321
146signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.43093321
147signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.43093321

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.85673294
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.42312771
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.82504429
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.36529391
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.20080379
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.97400232
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.91188526
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86569551
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85203917
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.84507428
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.82126831
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81622840
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.79049336
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78993869
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44935660
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34279075
17XRN2_22483619_ChIP-Seq_HELA_Human2.32205228
18* VDR_23849224_ChIP-Seq_CD4+_Human2.28590492
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.27611976
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21891901
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15200594
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07395113
23FOXP3_21729870_ChIP-Seq_TREG_Human2.02978359
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01656244
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99489469
26* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97500622
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.92348311
28DCP1A_22483619_ChIP-Seq_HELA_Human1.92295882
29* GABP_19822575_ChIP-Seq_HepG2_Human1.91571252
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.90032633
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89452267
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85376621
33AR_21909140_ChIP-Seq_LNCAP_Human1.85262138
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84209969
35MYC_22102868_ChIP-Seq_BL_Human1.82245443
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80362089
37TTF2_22483619_ChIP-Seq_HELA_Human1.80156566
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73186471
39CIITA_25753668_ChIP-Seq_RAJI_Human1.71537821
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70351401
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.68038881
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.64330565
43* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.62829561
44ELK1_19687146_ChIP-ChIP_HELA_Human1.61966169
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59520002
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59242395
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.58187395
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57085733
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56040737
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52275578
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51297229
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.50228395
53KDM5A_27292631_Chip-Seq_BREAST_Human1.50046872
54SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49506853
55NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48249495
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47175935
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45869276
58ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45857506
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42293041
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.40012399
61ZNF263_19887448_ChIP-Seq_K562_Human1.36585965
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.29034088
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27845034
64STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26508773
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26032920
66CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25304275
67* TFEB_21752829_ChIP-Seq_HELA_Human1.25197421
68SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23552717
69MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22086114
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20885125
71ELK3_25401928_ChIP-Seq_HUVEC_Human1.18240055
72VDR_21846776_ChIP-Seq_THP-1_Human1.18131967
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16931822
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.15445935
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.14351326
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14177621
77E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13270899
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.13059369
79* SPI1_23547873_ChIP-Seq_NB4_Human1.11500692
80* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09631937
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08346125
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08332280
83RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06918511
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06753443
85PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05960264
86MAF_26560356_Chip-Seq_TH1_Human1.05893644
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05653184
88NCOR1_26117541_ChIP-Seq_K562_Human1.05421100
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.05090831
90CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04591563
91* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04464463
92PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03046441
93BP1_19119308_ChIP-ChIP_Hs578T_Human1.02273650
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01058745
95* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96909549
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96456657
97TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96305192
98ATF3_27146783_Chip-Seq_COLON_Human0.95549261
99MAF_26560356_Chip-Seq_TH2_Human0.95415819
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95004402
101UTX_26944678_Chip-Seq_JUKART_Human0.94667472
102ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93751319
103BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93255234
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.92669383
105* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91311086
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.90146764
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.90130676
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89113533
109KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88549581
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88197158
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87090269
112MYC_18940864_ChIP-ChIP_HL60_Human0.87048984
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.86415636
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82621821
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.79867791
116MYB_26560356_Chip-Seq_TH1_Human0.77212055
117* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77161258
118* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75924029
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.75445528
120MYB_21317192_ChIP-Seq_ERMYB_Mouse0.75130800
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74593055

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30256229
2MP0010094_abnormal_chromosome_stability4.35361443
3MP0004957_abnormal_blastocyst_morpholog4.18994486
4MP0003111_abnormal_nucleus_morphology4.04514287
5MP0003077_abnormal_cell_cycle3.79037480
6MP0008057_abnormal_DNA_replication3.65238618
7MP0002877_abnormal_melanocyte_morpholog3.44952199
8MP0008058_abnormal_DNA_repair3.40893678
9MP0002396_abnormal_hematopoietic_system3.19790004
10MP0008007_abnormal_cellular_replicative2.82599449
11MP0005451_abnormal_body_composition2.59255051
12MP0010352_gastrointestinal_tract_polyps2.42833103
13MP0008932_abnormal_embryonic_tissue2.33042360
14MP0008260_abnormal_autophagy2.27964237
15* MP0001730_embryonic_growth_arrest2.17931274
16MP0003786_premature_aging2.06984136
17* MP0000350_abnormal_cell_proliferation2.06552624
18MP0004808_abnormal_hematopoietic_stem2.04282188
19MP0000490_abnormal_crypts_of2.00576681
20MP0003123_paternal_imprinting1.88962674
21MP0008877_abnormal_DNA_methylation1.82303570
22MP0010307_abnormal_tumor_latency1.75245728
23MP0004185_abnormal_adipocyte_glucose1.71197199
24MP0001672_abnormal_embryogenesis/_devel1.63072723
25MP0005380_embryogenesis_phenotype1.63072723
26MP0003763_abnormal_thymus_physiology1.60927374
27* MP0001697_abnormal_embryo_size1.60120894
28MP0001545_abnormal_hematopoietic_system1.58589258
29MP0005397_hematopoietic_system_phenotyp1.58589258
30MP0005501_abnormal_skin_physiology1.58267964
31MP0002019_abnormal_tumor_incidence1.58140350
32MP0000313_abnormal_cell_death1.56244529
33* MP0002080_prenatal_lethality1.55715645
34MP0002796_impaired_skin_barrier1.55087588
35MP0009333_abnormal_splenocyte_physiolog1.53278623
36MP0003718_maternal_effect1.50713060
37MP0003984_embryonic_growth_retardation1.49995587
38MP0004233_abnormal_muscle_weight1.49235074
39MP0002088_abnormal_embryonic_growth/wei1.45317196
40MP0002398_abnormal_bone_marrow1.43862836
41MP0003806_abnormal_nucleotide_metabolis1.37245394
42MP0002086_abnormal_extraembryonic_tissu1.36880693
43MP0000703_abnormal_thymus_morphology1.34395662
44MP0002085_abnormal_embryonic_tissue1.33045158
45MP0002084_abnormal_developmental_patter1.30977490
46MP0002722_abnormal_immune_system1.28834698
47MP0004197_abnormal_fetal_growth/weight/1.28069488
48MP0003656_abnormal_erythrocyte_physiolo1.27886083
49MP0003567_abnormal_fetal_cardiomyocyte1.27541592
50MP0001293_anophthalmia1.27267040
51MP0003705_abnormal_hypodermis_morpholog1.26984072
52MP0005075_abnormal_melanosome_morpholog1.26670530
53MP0003436_decreased_susceptibility_to1.25984598
54MP0000689_abnormal_spleen_morphology1.25534550
55MP0005058_abnormal_lysosome_morphology1.23518404
56MP0003453_abnormal_keratinocyte_physiol1.18171652
57MP0001853_heart_inflammation1.16947181
58MP0009697_abnormal_copulation1.16660197
59MP0002210_abnormal_sex_determination1.15539846
60MP0004947_skin_inflammation1.14976733
61MP0002429_abnormal_blood_cell1.10163020
62MP0001145_abnormal_male_reproductive1.06067239
63MP0003191_abnormal_cellular_cholesterol1.03314295
64* MP0000358_abnormal_cell_content/1.03202473
65MP0001881_abnormal_mammary_gland1.00976257
66MP0001835_abnormal_antigen_presentation1.00479214
67MP0006054_spinal_hemorrhage1.00372332
68MP0001216_abnormal_epidermal_layer0.98831177
69MP0001929_abnormal_gametogenesis0.98354547
70MP0000716_abnormal_immune_system0.98046477
71MP0002148_abnormal_hypersensitivity_rea0.97521345
72MP0005000_abnormal_immune_tolerance0.95688292
73MP0005174_abnormal_tail_pigmentation0.95241898
74MP0000678_abnormal_parathyroid_gland0.95137888
75MP0002132_abnormal_respiratory_system0.94814159
76MP0002060_abnormal_skin_morphology0.92767937
77MP0005671_abnormal_response_to0.92744105
78MP0001727_abnormal_embryo_implantation0.92388289
79MP0003121_genomic_imprinting0.91782385
80MP0000858_altered_metastatic_potential0.90791406
81MP0005023_abnormal_wound_healing0.90092667
82MP0000653_abnormal_sex_gland0.89917258
83MP0001790_abnormal_immune_system0.89401312
84MP0005387_immune_system_phenotype0.89401312
85MP0010234_abnormal_vibrissa_follicle0.89019965
86MP0003890_abnormal_embryonic-extraembry0.88420066
87MP0005025_abnormal_response_to0.85150656
88MP0001800_abnormal_humoral_immune0.84978261
89MP0003186_abnormal_redox_activity0.84636489
90MP0001915_intracranial_hemorrhage0.83824464
91MP0003448_altered_tumor_morphology0.83185179
92MP0002095_abnormal_skin_pigmentation0.82645295
93MP0006292_abnormal_olfactory_placode0.82460158
94MP0000685_abnormal_immune_system0.82272684
95MP0002420_abnormal_adaptive_immunity0.81463727
96MP0005464_abnormal_platelet_physiology0.81445226
97MP0005076_abnormal_cell_differentiation0.81139314
98MP0003300_gastrointestinal_ulcer0.80954924
99MP0001819_abnormal_immune_cell0.80884752
100MP0002419_abnormal_innate_immunity0.80280807
101MP0002405_respiratory_system_inflammati0.79482040
102MP0002452_abnormal_antigen_presenting0.79238622
103* MP0005384_cellular_phenotype0.79058650
104MP0001119_abnormal_female_reproductive0.78752891
105MP0000465_gastrointestinal_hemorrhage0.78043668
106MP0003566_abnormal_cell_adhesion0.77465429
107MP0003315_abnormal_perineum_morphology0.77460013
108MP0001243_abnormal_dermal_layer0.74925639
109MP0000477_abnormal_intestine_morphology0.74863694
110MP0009672_abnormal_birth_weight0.74829978
111MP0005621_abnormal_cell_physiology0.73883527
112MP0000371_diluted_coat_color0.71950268
113MP0002723_abnormal_immune_serum0.71540683
114MP0009278_abnormal_bone_marrow0.70346178
115MP0004147_increased_porphyrin_level0.69982595
116MP0001849_ear_inflammation0.69042552
117MP0002092_abnormal_eye_morphology0.68493274
118MP0002166_altered_tumor_susceptibility0.68207571
119MP0003943_abnormal_hepatobiliary_system0.66400486
120MP0010155_abnormal_intestine_physiology0.66190114
121MP0001873_stomach_inflammation0.65007364
122MP0002075_abnormal_coat/hair_pigmentati0.64820183
123MP0003221_abnormal_cardiomyocyte_apopto0.62951644
124MP0002111_abnormal_tail_morphology0.61904969
125MP0003119_abnormal_digestive_system0.61498753
126MP0006035_abnormal_mitochondrial_morpho0.61253732
127MP0002160_abnormal_reproductive_system0.61183294
128MP0005389_reproductive_system_phenotype0.61140309
129MP0002006_tumorigenesis0.60613381
130MP0008995_early_reproductive_senescence0.60436796
131MP0001919_abnormal_reproductive_system0.57431167
132MP0004264_abnormal_extraembryonic_tissu0.57126927
133MP0006036_abnormal_mitochondrial_physio0.57053810

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.05319771
2Birth length less than 3rd percentile (HP:0003561)4.99209950
3Abnormal number of erythroid precursors (HP:0012131)4.83665754
4Reticulocytopenia (HP:0001896)4.58739755
5Aplastic anemia (HP:0001915)3.69774478
6Oral leukoplakia (HP:0002745)3.55620274
7Abnormality of the anterior horn cell (HP:0006802)3.55021392
8Degeneration of anterior horn cells (HP:0002398)3.55021392
9Selective tooth agenesis (HP:0001592)3.38376348
10Colon cancer (HP:0003003)3.33895697
11Pallor (HP:0000980)3.32017140
12Chromsome breakage (HP:0040012)3.30131618
13Ragged-red muscle fibers (HP:0003200)3.21907154
14Thrombocytosis (HP:0001894)3.20767306
15Breast hypoplasia (HP:0003187)3.12087342
16Rough bone trabeculation (HP:0100670)3.08140444
17Cholecystitis (HP:0001082)3.05814394
18Abnormal gallbladder physiology (HP:0012438)3.05814394
19Macrocytic anemia (HP:0001972)2.99102975
20Microretrognathia (HP:0000308)2.96194054
21Abnormality of chromosome stability (HP:0003220)2.94166695
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93397442
23Ependymoma (HP:0002888)2.91937760
24Myelodysplasia (HP:0002863)2.91310384
25Abnormality of the preputium (HP:0100587)2.86544628
26Medulloblastoma (HP:0002885)2.82525505
27Absent thumb (HP:0009777)2.78746460
28Abnormality of glycolysis (HP:0004366)2.76782075
29Progressive external ophthalmoplegia (HP:0000590)2.75209781
30Premature graying of hair (HP:0002216)2.74089145
31Meckel diverticulum (HP:0002245)2.71023847
3211 pairs of ribs (HP:0000878)2.70977053
33Patellar aplasia (HP:0006443)2.66699693
34Abnormality of the ileum (HP:0001549)2.64912648
35IgM deficiency (HP:0002850)2.62806025
36Cerebral hypomyelination (HP:0006808)2.59230742
37Increased serum pyruvate (HP:0003542)2.58626398
38Agnosia (HP:0010524)2.54905315
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.53742815
40Basal cell carcinoma (HP:0002671)2.53564668
41Impulsivity (HP:0100710)2.52678636
42Hyperacusis (HP:0010780)2.50960276
43Neoplasm of the pancreas (HP:0002894)2.50833598
44Aplasia/Hypoplasia of the patella (HP:0006498)2.49769873
45Bone marrow hypocellularity (HP:0005528)2.46798216
46Orthostatic hypotension (HP:0001278)2.46791251
47Hypertensive crisis (HP:0100735)2.46581610
48Upper limb muscle weakness (HP:0003484)2.45537562
49Insomnia (HP:0100785)2.44352094
50Trismus (HP:0000211)2.41554054
51Premature ovarian failure (HP:0008209)2.40906169
52Amaurosis fugax (HP:0100576)2.40423724
53Muscle fiber atrophy (HP:0100295)2.39392370
54Carpal bone hypoplasia (HP:0001498)2.36465484
55Recurrent viral infections (HP:0004429)2.30918199
56Rhabdomyosarcoma (HP:0002859)2.30663215
57Increased nuchal translucency (HP:0010880)2.29879173
58Type 2 muscle fiber atrophy (HP:0003554)2.27854081
59Abnormality of oral frenula (HP:0000190)2.26527483
60Atrophy/Degeneration involving motor neurons (HP:0007373)2.22211745
61Multiple enchondromatosis (HP:0005701)2.22123503
62Progressive muscle weakness (HP:0003323)2.19640748
63Pancytopenia (HP:0001876)2.18667022
64Lymphoma (HP:0002665)2.18519633
65Abnormality of the heme biosynthetic pathway (HP:0010472)2.18445041
66Prominent nose (HP:0000448)2.16981499
67Increased connective tissue (HP:0009025)2.15454239
68Sloping forehead (HP:0000340)2.14780716
69Squamous cell carcinoma (HP:0002860)2.14636120
70Abnormal trabecular bone morphology (HP:0100671)2.14525718
71Cellular immunodeficiency (HP:0005374)2.13224644
72Abnormality of the umbilical cord (HP:0010881)2.12836632
73Proximal placement of thumb (HP:0009623)2.11687175
74Small intestinal stenosis (HP:0012848)2.09520797
75Duodenal stenosis (HP:0100867)2.09520797
76Aplasia/Hypoplasia of the thymus (HP:0010515)2.08200444
77Neoplasm of the oral cavity (HP:0100649)2.08018374
78Secondary amenorrhea (HP:0000869)2.06316949
79Slender long bone (HP:0003100)2.04764815
80Type I transferrin isoform profile (HP:0003642)2.03981209
81Distal lower limb amyotrophy (HP:0008944)2.03785292
82Deviation of the thumb (HP:0009603)2.03219207
83Microvesicular hepatic steatosis (HP:0001414)2.02096879
84Poikiloderma (HP:0001029)2.01856571
85Fatigue (HP:0012378)2.00263697
86Glossoptosis (HP:0000162)1.99104667
87Decreased activity of mitochondrial respiratory chain (HP:0008972)1.98083492
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.98083492
89Abnormal number of incisors (HP:0011064)1.96751413
90Entropion (HP:0000621)1.95325802
91Achilles tendon contracture (HP:0001771)1.94858018
92Reduced antithrombin III activity (HP:0001976)1.94482397
93Abnormality of the distal phalanges of the toes (HP:0010182)1.93254217
94Spinal muscular atrophy (HP:0007269)1.91194859
95Vertebral compression fractures (HP:0002953)1.90911280
96Atresia of the external auditory canal (HP:0000413)1.90549540
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89644842
98Cleft eyelid (HP:0000625)1.89067894
99Tracheoesophageal fistula (HP:0002575)1.87781021
100Acute myeloid leukemia (HP:0004808)1.87341172
101Tongue fasciculations (HP:0001308)1.87258663
102Absent radius (HP:0003974)1.86856570
103Abnormality of reticulocytes (HP:0004312)1.85463714
104Ankyloglossia (HP:0010296)1.84449812
105Horseshoe kidney (HP:0000085)1.84270100
106Petechiae (HP:0000967)1.83721546
107Hypoplasia of the pons (HP:0012110)1.83279537
108Abnormal spermatogenesis (HP:0008669)1.83122506
109Abnormality of DNA repair (HP:0003254)1.82788894
110Spastic paraparesis (HP:0002313)1.82179487
111Volvulus (HP:0002580)1.81975877
112Neoplasm of the colon (HP:0100273)1.81766491
113Pulmonary fibrosis (HP:0002206)1.81469050
114Abnormality of the fetal cardiovascular system (HP:0010948)1.81440892
115Abnormal umbilical cord blood vessels (HP:0011403)1.81440892
116Single umbilical artery (HP:0001195)1.81440892
117Sparse eyelashes (HP:0000653)1.80674277
118Acute lymphatic leukemia (HP:0006721)1.79917213
119Long palpebral fissure (HP:0000637)1.78028070
120Abnormality of the duodenum (HP:0002246)1.76692613
121Reticulocytosis (HP:0001923)1.75446742
122Micronodular cirrhosis (HP:0001413)1.75171942
123Triphalangeal thumb (HP:0001199)1.74725281
124Glioma (HP:0009733)1.73628017
125Centrally nucleated skeletal muscle fibers (HP:0003687)1.72427457
126Cholelithiasis (HP:0001081)1.72178156
127Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71873860
128Abnormal protein N-linked glycosylation (HP:0012347)1.71873860
129Abnormal protein glycosylation (HP:0012346)1.71873860
130Abnormal glycosylation (HP:0012345)1.71873860
131Supernumerary spleens (HP:0009799)1.71731592
132Cutaneous melanoma (HP:0012056)1.71495595
133Cafe-au-lait spot (HP:0000957)1.71361255
134Deep philtrum (HP:0002002)1.70998539
135Abnormality of alanine metabolism (HP:0010916)1.70591905
136Hyperalaninemia (HP:0003348)1.70591905
137Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70591905
138Hepatosplenomegaly (HP:0001433)1.70438576
139Missing ribs (HP:0000921)1.69842587
140Autoamputation (HP:0001218)1.69699989
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69575686
142Pelvic girdle muscle weakness (HP:0003749)1.69361240
143Abnormality of the pons (HP:0007361)1.68966670
144Nail dystrophy (HP:0008404)1.68025605
145Viral hepatitis (HP:0006562)1.66533350
146IgA deficiency (HP:0002720)1.65960122
147Nonimmune hydrops fetalis (HP:0001790)1.65309015
148Hypergonadotropic hypogonadism (HP:0000815)1.64705514
149Osteolytic defects of the phalanges of the hand (HP:0009771)1.64608353
150Osteolytic defects of the hand bones (HP:0009699)1.64608353
151Increased serum lactate (HP:0002151)1.63979999
152Abnormalities of placenta or umbilical cord (HP:0001194)1.63918267
153Slow saccadic eye movements (HP:0000514)1.63628901
154Testicular atrophy (HP:0000029)1.63131220
155Fasciculations (HP:0002380)1.62130427
156Seborrheic dermatitis (HP:0001051)1.60597782
157Mediastinal lymphadenopathy (HP:0100721)1.60596232
158Progressive hearing impairment (HP:0001730)1.60420723
159Abnormal autonomic nervous system physiology (HP:0012332)1.59563060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE14.01812466
2BUB13.97657868
3CDC73.87181067
4EIF2AK12.94479179
5NME22.86381366
6VRK22.69230112
7NEK22.65074842
8SMG12.55457143
9IRAK32.45206678
10ACVR1B2.34846728
11SRPK12.32660349
12MST1R2.24938383
13TSSK62.23679521
14PBK2.17572601
15STK162.13156786
16TTK1.95410373
17DYRK31.94467565
18BRSK21.90220922
19VRK11.86407855
20PLK41.83709316
21EIF2AK31.82698133
22RPS6KA41.79495813
23CDK71.75171830
24PLK11.74544757
25PASK1.74263055
26FLT31.73065378
27ATR1.72363523
28TLK11.68197959
29RPS6KB21.62089061
30TESK21.59588425
31EEF2K1.59547983
32CDK121.59495338
33AURKB1.58283416
34ERN11.56719276
35TGFBR11.52816617
36NEK11.50678530
37MST41.50026608
38PRPF4B1.45998459
39MAP4K11.45582900
40SCYL21.44072252
41MKNK11.43787530
42STK101.39809865
43CDK41.34862064
44PIM21.31106894
45MAP3K81.30834452
46ICK1.29023808
47PLK31.22952948
48ARAF1.22163947
49ZAK1.22119399
50AURKA1.17709489
51CHEK11.14062860
52CCNB11.13661256
53PDK21.11097271
54EPHA21.09994472
55PIM11.05495146
56* CHEK21.04681251
57JAK31.04555216
58SIK31.03683093
59BRSK11.02247129
60MAP3K141.01378652
61TRIB30.99263205
62IRAK40.95131933
63KDR0.95042611
64PAK40.94455540
65BTK0.92788270
66LRRK20.90982370
67BRD40.90406638
68DAPK10.87887055
69KIT0.86314167
70CLK10.84467674
71MKNK20.84192438
72NME10.82625118
73CDK20.79140943
74ZAP700.76613326
75MAP3K100.74990347
76* ATM0.74748486
77TEC0.73339376
78MAPKAPK30.72105713
79MAP3K110.71385187
80RIPK40.71342486
81CSNK2A20.70464946
82PAK10.70271701
83MATK0.70266650
84CSF1R0.70189829
85EIF2AK20.68962039
86MAP2K30.68621146
87ERBB40.67853682
88CDK80.64796091
89STK40.62677497
90CSNK2A10.62337810
91PKN20.58830134
92MELK0.56432460
93RPS6KA50.55302021
94TBK10.55030258
95ALK0.54953186
96IRAK20.54312752
97CSK0.54167269
98CDK60.53946138
99CDK90.53570545
100MAP3K30.53457874
101TESK10.53304537
102MAP3K130.50886898
103MOS0.47736002
104MAP3K10.46951289
105TAF10.46367078
106CDK10.46194593
107BMPR20.45635256
108MET0.45226689
109TXK0.44208605
110BMX0.44200529
111MTOR0.42423850
112STK30.40210128
113IKBKB0.39551911
114BCKDK0.39043841
115MAPK110.38679095
116KSR20.38396019
117PRKCI0.37372883
118SIK10.37061330
119PDK30.35867371
120PDK40.35867371
121CHUK0.35821773
122PAK20.35158446
123TYK20.34162353
124LYN0.33903996
125RAF10.33393446
126TAOK20.32685618
127CDK190.30407572
128SYK0.30341677
129CSNK1E0.30183289
130MARK30.29208457
131AKT20.28799638
132BLK0.27191104
133RPS6KB10.25058917
134BRAF0.23648016

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.77800613
2Mismatch repair_Homo sapiens_hsa034303.93209469
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.80957996
4Ribosome_Homo sapiens_hsa030103.70072203
5Spliceosome_Homo sapiens_hsa030403.31459692
6RNA polymerase_Homo sapiens_hsa030203.20775687
7RNA transport_Homo sapiens_hsa030133.11042705
8Proteasome_Homo sapiens_hsa030503.06947756
9Base excision repair_Homo sapiens_hsa034102.94090695
10Homologous recombination_Homo sapiens_hsa034402.75521827
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72728304
12Nucleotide excision repair_Homo sapiens_hsa034202.66242953
13One carbon pool by folate_Homo sapiens_hsa006702.59400180
14Pyrimidine metabolism_Homo sapiens_hsa002402.50609287
15Cell cycle_Homo sapiens_hsa041102.49304998
16Fanconi anemia pathway_Homo sapiens_hsa034602.09914895
17Non-homologous end-joining_Homo sapiens_hsa034502.08237451
18RNA degradation_Homo sapiens_hsa030181.85157371
19Basal transcription factors_Homo sapiens_hsa030221.79043686
20p53 signaling pathway_Homo sapiens_hsa041151.63945409
21mRNA surveillance pathway_Homo sapiens_hsa030151.63884856
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.51431120
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.33835969
24Purine metabolism_Homo sapiens_hsa002301.27730252
25Systemic lupus erythematosus_Homo sapiens_hsa053221.24119444
26Epstein-Barr virus infection_Homo sapiens_hsa051691.21566400
27Antigen processing and presentation_Homo sapiens_hsa046121.12355671
28Herpes simplex infection_Homo sapiens_hsa051681.09347840
29Folate biosynthesis_Homo sapiens_hsa007901.05131256
30Viral carcinogenesis_Homo sapiens_hsa052031.01492324
31Selenocompound metabolism_Homo sapiens_hsa004500.97335521
32Cysteine and methionine metabolism_Homo sapiens_hsa002700.94802405
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94177718
34Pancreatic cancer_Homo sapiens_hsa052120.93873302
35Vitamin B6 metabolism_Homo sapiens_hsa007500.93448844
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90203967
37Pentose phosphate pathway_Homo sapiens_hsa000300.88921540
38Drug metabolism - other enzymes_Homo sapiens_hsa009830.84958803
39Sulfur relay system_Homo sapiens_hsa041220.79326642
40Primary immunodeficiency_Homo sapiens_hsa053400.77283141
41HTLV-I infection_Homo sapiens_hsa051660.75834825
42Pyruvate metabolism_Homo sapiens_hsa006200.75532921
43Biosynthesis of amino acids_Homo sapiens_hsa012300.73397018
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69408272
45Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68675987
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.67208970
47Protein export_Homo sapiens_hsa030600.66990243
48Legionellosis_Homo sapiens_hsa051340.65474022
49Thyroid cancer_Homo sapiens_hsa052160.62940947
50Oocyte meiosis_Homo sapiens_hsa041140.61929261
51Measles_Homo sapiens_hsa051620.60018949
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58226666
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58009645
54Salmonella infection_Homo sapiens_hsa051320.57571831
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.56263596
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56041093
57N-Glycan biosynthesis_Homo sapiens_hsa005100.55964651
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55749085
59Renal cell carcinoma_Homo sapiens_hsa052110.54267029
60Small cell lung cancer_Homo sapiens_hsa052220.54162062
61Apoptosis_Homo sapiens_hsa042100.53896632
62MicroRNAs in cancer_Homo sapiens_hsa052060.53212631
63T cell receptor signaling pathway_Homo sapiens_hsa046600.51437367
64Other glycan degradation_Homo sapiens_hsa005110.51291823
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50993235
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49310660
67Shigellosis_Homo sapiens_hsa051310.46497059
68Hepatitis B_Homo sapiens_hsa051610.42933295
69Fatty acid elongation_Homo sapiens_hsa000620.42474943
70Adherens junction_Homo sapiens_hsa045200.42348386
71Acute myeloid leukemia_Homo sapiens_hsa052210.41869494
72Glutathione metabolism_Homo sapiens_hsa004800.41567794
73Fructose and mannose metabolism_Homo sapiens_hsa000510.40111698
74Carbon metabolism_Homo sapiens_hsa012000.39252293
75Galactose metabolism_Homo sapiens_hsa000520.38074448
76Notch signaling pathway_Homo sapiens_hsa043300.37744283
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36777311
78Chronic myeloid leukemia_Homo sapiens_hsa052200.36464912
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36215246
80Hematopoietic cell lineage_Homo sapiens_hsa046400.36089522
81RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.34826170
82Endocytosis_Homo sapiens_hsa041440.33700380
83Hepatitis C_Homo sapiens_hsa051600.33629465
84TNF signaling pathway_Homo sapiens_hsa046680.33125344
85Prion diseases_Homo sapiens_hsa050200.32963049
86Prostate cancer_Homo sapiens_hsa052150.32644345
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31837775
88Influenza A_Homo sapiens_hsa051640.31615112
89Parkinsons disease_Homo sapiens_hsa050120.31517744
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31420800
91Caffeine metabolism_Homo sapiens_hsa002320.31175651
92Toxoplasmosis_Homo sapiens_hsa051450.30712701
93Vibrio cholerae infection_Homo sapiens_hsa051100.30456881
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.30384749
95Alcoholism_Homo sapiens_hsa050340.29168016
96Intestinal immune network for IgA production_Homo sapiens_hsa046720.28441572
97Bladder cancer_Homo sapiens_hsa052190.28168675
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27858446
99Colorectal cancer_Homo sapiens_hsa052100.27614164
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27532814
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.25104126
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.24624165
103Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23328998
104NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22773709
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22579211
106B cell receptor signaling pathway_Homo sapiens_hsa046620.21938663
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.21927101
108TGF-beta signaling pathway_Homo sapiens_hsa043500.21256089
109HIF-1 signaling pathway_Homo sapiens_hsa040660.20692220
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20028839
111Metabolic pathways_Homo sapiens_hsa011000.19415180
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19191967
113Leishmaniasis_Homo sapiens_hsa051400.18700172
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17536840
115Viral myocarditis_Homo sapiens_hsa054160.17311285
116Renin-angiotensin system_Homo sapiens_hsa046140.17221305
117Pathways in cancer_Homo sapiens_hsa052000.16929177
118Huntingtons disease_Homo sapiens_hsa050160.16889836
119Regulation of autophagy_Homo sapiens_hsa041400.15068917
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11528480
121Non-small cell lung cancer_Homo sapiens_hsa052230.11167790
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10975196

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