ABAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.22888255
2L-phenylalanine catabolic process (GO:0006559)5.22888255
3L-phenylalanine metabolic process (GO:0006558)4.90055031
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.90055031
5postsynaptic membrane organization (GO:0001941)4.84976422
6aromatic amino acid family catabolic process (GO:0009074)4.59086824
7synaptic vesicle docking involved in exocytosis (GO:0016081)4.36956019
8central nervous system myelination (GO:0022010)4.27747656
9axon ensheathment in central nervous system (GO:0032291)4.27747656
10pyrimidine nucleobase catabolic process (GO:0006208)4.18954509
11cellular potassium ion homeostasis (GO:0030007)4.17530381
12glutamate metabolic process (GO:0006536)4.12943218
13alpha-linolenic acid metabolic process (GO:0036109)4.12866238
14bile acid biosynthetic process (GO:0006699)4.07912352
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.05754352
16kynurenine metabolic process (GO:0070189)4.05264921
17presynaptic membrane assembly (GO:0097105)4.03863025
18gamma-aminobutyric acid transport (GO:0015812)4.02649413
19indole-containing compound catabolic process (GO:0042436)4.01867536
20indolalkylamine catabolic process (GO:0046218)4.01867536
21tryptophan catabolic process (GO:0006569)4.01867536
22neuron cell-cell adhesion (GO:0007158)4.01610089
23dicarboxylic acid biosynthetic process (GO:0043650)3.91260425
24glyoxylate metabolic process (GO:0046487)3.90940654
25L-amino acid import (GO:0043092)3.87778154
26presynaptic membrane organization (GO:0097090)3.86145466
27ionotropic glutamate receptor signaling pathway (GO:0035235)3.85009445
28membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.82926684
29sodium ion export (GO:0071436)3.79297217
30tryptophan metabolic process (GO:0006568)3.74454031
31lysine metabolic process (GO:0006553)3.74433175
32lysine catabolic process (GO:0006554)3.74433175
33cysteine metabolic process (GO:0006534)3.74135237
34urea cycle (GO:0000050)3.69688703
35urea metabolic process (GO:0019627)3.69688703
36regulation of short-term neuronal synaptic plasticity (GO:0048172)3.60240620
37cerebellar granule cell differentiation (GO:0021707)3.59621375
38exploration behavior (GO:0035640)3.58425095
39cellular ketone body metabolic process (GO:0046950)3.58128645
40locomotory exploration behavior (GO:0035641)3.57988896
41high-density lipoprotein particle remodeling (GO:0034375)3.57581781
42nucleobase catabolic process (GO:0046113)3.55967032
43synaptic vesicle maturation (GO:0016188)3.55719801
44neuronal action potential propagation (GO:0019227)3.55383306
45amino acid import (GO:0043090)3.53681574
46sulfur amino acid catabolic process (GO:0000098)3.51555923
47dendritic spine morphogenesis (GO:0060997)3.49173150
48bile acid metabolic process (GO:0008206)3.44313584
49drug catabolic process (GO:0042737)3.44186452
50auditory behavior (GO:0031223)3.42425791
51nitrogen cycle metabolic process (GO:0071941)3.39608177
52protein localization to synapse (GO:0035418)3.39567736
53regulation of synapse structural plasticity (GO:0051823)3.39260600
54dicarboxylic acid catabolic process (GO:0043649)3.36011120
55alpha-amino acid catabolic process (GO:1901606)3.35789150
56positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.35576388
57synaptic transmission, glutamatergic (GO:0035249)3.34986573
58potassium ion import (GO:0010107)3.31934211
59serine family amino acid catabolic process (GO:0009071)3.31907638
60negative regulation of fibrinolysis (GO:0051918)3.31593964
61positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.31214675
62aromatic amino acid family metabolic process (GO:0009072)3.30128333
63cellular modified amino acid catabolic process (GO:0042219)3.27089501
64* neurotransmitter secretion (GO:0007269)3.25986376
65homocysteine metabolic process (GO:0050667)3.25200994
66reverse cholesterol transport (GO:0043691)3.24922145
67cellular sodium ion homeostasis (GO:0006883)3.24704345
68epoxygenase P450 pathway (GO:0019373)3.24459663
69response to auditory stimulus (GO:0010996)3.24013998
70vocalization behavior (GO:0071625)3.20056551
71fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19686202
72omega-hydroxylase P450 pathway (GO:0097267)3.19022383
73regulation of fibrinolysis (GO:0051917)3.17083042
74regulation of cholesterol esterification (GO:0010872)3.16068483
75aspartate family amino acid catabolic process (GO:0009068)3.15526177
76* cellular amino acid catabolic process (GO:0009063)3.15412505
77potassium ion homeostasis (GO:0055075)3.15376864
78regulation of protein activation cascade (GO:2000257)3.14379581
79exogenous drug catabolic process (GO:0042738)3.14305824
80protein carboxylation (GO:0018214)3.13558843
81peptidyl-glutamic acid carboxylation (GO:0017187)3.13558843
82complement activation, alternative pathway (GO:0006957)3.13294183
83cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.13080092
84tyrosine metabolic process (GO:0006570)3.12935830
85axonal fasciculation (GO:0007413)3.12199149
86transmission of nerve impulse (GO:0019226)3.12001152
87protein-lipid complex remodeling (GO:0034368)3.11557587
88macromolecular complex remodeling (GO:0034367)3.11557587
89plasma lipoprotein particle remodeling (GO:0034369)3.11557587
90glutamate secretion (GO:0014047)3.11471273
91ketone body metabolic process (GO:1902224)3.09451439
92coenzyme catabolic process (GO:0009109)3.09201728
93short-chain fatty acid metabolic process (GO:0046459)3.07799064
94glutamate receptor signaling pathway (GO:0007215)3.07432374
95amino-acid betaine metabolic process (GO:0006577)3.07233972
96C4-dicarboxylate transport (GO:0015740)3.05440751
97neurotransmitter-gated ion channel clustering (GO:0072578)3.04745982
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.01531096
99negative regulation of sterol transport (GO:0032372)3.00020533
100negative regulation of cholesterol transport (GO:0032375)3.00020533
101neuron recognition (GO:0008038)2.99876577
102negative regulation of synaptic transmission, GABAergic (GO:0032229)2.99393889
103indolalkylamine metabolic process (GO:0006586)2.96140429
104neuron-neuron synaptic transmission (GO:0007270)2.95493469
105synaptic vesicle exocytosis (GO:0016079)2.95075390
106regulation of complement activation (GO:0030449)2.91449584
107neurotransmitter uptake (GO:0001504)2.89957091
108positive regulation of synapse maturation (GO:0090129)2.88839498
109acylglycerol homeostasis (GO:0055090)2.86509879
110triglyceride homeostasis (GO:0070328)2.86509879
111neuronal ion channel clustering (GO:0045161)2.86100560
112regulation of synaptic vesicle exocytosis (GO:2000300)2.86054874
113layer formation in cerebral cortex (GO:0021819)2.85698132
114low-density lipoprotein particle remodeling (GO:0034374)2.84581191
115drug transmembrane transport (GO:0006855)2.83631636
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.83623010
117positive regulation of membrane potential (GO:0045838)2.82441332
118neuromuscular process controlling posture (GO:0050884)2.82205351
119regulation of triglyceride catabolic process (GO:0010896)2.82133562
120synaptic vesicle endocytosis (GO:0048488)2.81263825
121regulation of cholesterol homeostasis (GO:2000188)2.80716011
122mechanosensory behavior (GO:0007638)2.79741867
123regulation of glutamate receptor signaling pathway (GO:1900449)2.78359179
124regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.76971696
125positive regulation of dendritic spine development (GO:0060999)2.76682420
126glutamine family amino acid catabolic process (GO:0009065)2.76432681
127phospholipid efflux (GO:0033700)2.75746929
128bile acid and bile salt transport (GO:0015721)2.75707564
129glycine transport (GO:0015816)2.74555074
130cholesterol efflux (GO:0033344)2.74368619
131cell communication by electrical coupling (GO:0010644)2.73636278
132benzene-containing compound metabolic process (GO:0042537)2.72792612
133acidic amino acid transport (GO:0015800)2.72605766
134positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.71562034
1352-oxoglutarate metabolic process (GO:0006103)2.71435667
136regulation of neurotransmitter secretion (GO:0046928)2.71150713
137arginine metabolic process (GO:0006525)2.70807855
138succinate metabolic process (GO:0006105)2.70345058
139regulation of neuronal synaptic plasticity (GO:0048168)2.69771070
140indole-containing compound metabolic process (GO:0042430)2.69383271
141regulation of long-term neuronal synaptic plasticity (GO:0048169)2.69223928
142establishment of mitochondrion localization (GO:0051654)2.67862228
143regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.67711814
144regulation of dendritic spine morphogenesis (GO:0061001)2.67675927
145dendrite morphogenesis (GO:0048813)2.66963516
146cellular glucuronidation (GO:0052695)2.66188130
147ethanol oxidation (GO:0006069)2.65217631
148* neurotransmitter transport (GO:0006836)2.64846790
149positive regulation of dendritic spine morphogenesis (GO:0061003)2.63176454
150* regulation of neurotransmitter levels (GO:0001505)2.62219353
151regulation of synaptic vesicle transport (GO:1902803)2.61562375
152* organic acid catabolic process (GO:0016054)2.61238367
153* carboxylic acid catabolic process (GO:0046395)2.61238367
154alanine transport (GO:0032328)2.61190339
155amine catabolic process (GO:0009310)2.60973045
156cellular biogenic amine catabolic process (GO:0042402)2.60973045
157positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.60906557
158regulation of neurotransmitter transport (GO:0051588)2.60447593
159regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59477780
160long-term memory (GO:0007616)2.58967177
161regulation of synaptic transmission, glutamatergic (GO:0051966)2.56470239
162neuromuscular process controlling balance (GO:0050885)2.53962645
163regulation of postsynaptic membrane potential (GO:0060078)2.52365726
164adult walking behavior (GO:0007628)2.48943353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.47654432
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.89454249
3EZH2_22144423_ChIP-Seq_EOC_Human3.42708867
4* LXR_22158963_ChIP-Seq_LIVER_Mouse3.15412099
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.10426252
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.70781964
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.45074633
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.36359215
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32546296
10GBX2_23144817_ChIP-Seq_PC3_Human2.32178274
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22189052
12DROSHA_22980978_ChIP-Seq_HELA_Human2.04420019
13* REST_21632747_ChIP-Seq_MESCs_Mouse2.03791156
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00021119
15* RARB_27405468_Chip-Seq_BRAIN_Mouse1.99572791
16MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99443300
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97299478
18EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94639339
19RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94639339
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93915432
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90812712
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.89428520
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84740835
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81499623
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.80858944
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.80059903
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.79943941
28PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.78624079
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.69179025
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.66237534
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.66079615
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65846142
33TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.64609600
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.60345295
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.57981704
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52838472
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.50971409
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48213743
39* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47950997
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43213968
41TAF15_26573619_Chip-Seq_HEK293_Human1.41382126
42CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39770388
43AR_21572438_ChIP-Seq_LNCaP_Human1.38847676
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.35642416
45CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32062605
46* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28711807
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.26481102
48RNF2_27304074_Chip-Seq_NSC_Mouse1.22654279
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22153723
50TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21118726
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20640855
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19335864
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18831834
54SMAD4_21799915_ChIP-Seq_A2780_Human1.18066513
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.17792371
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.13804427
57* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12300045
58IGF1R_20145208_ChIP-Seq_DFB_Human1.11708186
59* RING1B_27294783_Chip-Seq_NPCs_Mouse1.11060268
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.10098967
61* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10091351
62TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09534431
63HTT_18923047_ChIP-ChIP_STHdh_Human1.09336401
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08395223
65TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06955126
66POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06955126
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06657681
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06523201
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05912376
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.05244768
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04945970
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04777118
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03952850
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03130571
75OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.02941051
76AR_19668381_ChIP-Seq_PC3_Human1.01643704
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00727392
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00414191
79POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00383138
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99565087
81WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98841556
82CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97525106
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95895665
84* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95445945
85* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95384801
86* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95213665
87CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94587793
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94363119
89STAT3_23295773_ChIP-Seq_U87_Human0.93785863
90RING1B_27294783_Chip-Seq_ESCs_Mouse0.93380979
91* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92823887
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92443843
93SMAD4_21741376_ChIP-Seq_HESCs_Human0.92268640
94* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92230073
95LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92222048
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90285120
97AR_25329375_ChIP-Seq_VCAP_Human0.90059419
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.87524494
99P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87014654
100P300_19829295_ChIP-Seq_ESCs_Human0.86796015
101BCAT_22108803_ChIP-Seq_LS180_Human0.86077099
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.84967821
103SMAD3_21741376_ChIP-Seq_EPCs_Human0.84295315
104CTCF_27219007_Chip-Seq_Bcells_Human0.83052911
105* KDM2B_26808549_Chip-Seq_K562_Human0.82900136
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82508995
107ESR1_20079471_ChIP-ChIP_T-47D_Human0.81630139
108ZNF274_21170338_ChIP-Seq_K562_Hela0.81435099
109SMAD4_21741376_ChIP-Seq_EPCs_Human0.81187032
110TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81113924
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.80527804
112* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80019903
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79862097
114GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78949830
115* ESR2_21235772_ChIP-Seq_MCF-7_Human0.78347680
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.77665323
117GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76276990
118RXR_22108803_ChIP-Seq_LS180_Human0.76078791
119KLF4_19829295_ChIP-Seq_ESCs_Human0.75922375
120AHR_22903824_ChIP-Seq_MCF-7_Human0.75461430
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75420446
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75420446
123SMAD3_21741376_ChIP-Seq_HESCs_Human0.74143065
124TCF4_23295773_ChIP-Seq_U87_Human0.73444399
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.73101009
126ZFP281_18757296_ChIP-ChIP_E14_Mouse0.72322449

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.55278629
2MP0005360_urolithiasis5.27087082
3MP0005085_abnormal_gallbladder_physiolo4.28757477
4MP0005365_abnormal_bile_salt3.95783179
5MP0004859_abnormal_synaptic_plasticity3.86008587
6MP0002822_catalepsy3.61040688
7MP0008875_abnormal_xenobiotic_pharmacok3.46539270
8MP0003635_abnormal_synaptic_transmissio2.62866019
9MP0003252_abnormal_bile_duct2.57850273
10MP0003122_maternal_imprinting2.48696552
11MP0010329_abnormal_lipoprotein_level2.47980329
12MP0003880_abnormal_central_pattern2.43102205
13MP0009745_abnormal_behavioral_response2.31927383
14MP0003195_calcinosis2.29165366
15MP0005332_abnormal_amino_acid2.22470207
16MP0002064_seizures2.17759463
17MP0009046_muscle_twitch2.14282272
18MP0004270_analgesia2.11658668
19MP0002063_abnormal_learning/memory/cond2.08716405
20MP0003329_amyloid_beta_deposits1.95475175
21MP0003806_abnormal_nucleotide_metabolis1.89159874
22MP0005083_abnormal_biliary_tract1.88884416
23MP0003136_yellow_coat_color1.82183754
24MP0002572_abnormal_emotion/affect_behav1.76812526
25MP0005423_abnormal_somatic_nervous1.74256652
26MP0003787_abnormal_imprinting1.72639891
27MP0001486_abnormal_startle_reflex1.70231613
28MP0001666_abnormal_nutrient_absorption1.69231998
29MP0002272_abnormal_nervous_system1.68051113
30MP0002909_abnormal_adrenal_gland1.67445734
31MP0001501_abnormal_sleep_pattern1.65298394
32MP0009840_abnormal_foam_cell1.62866442
33MP0009780_abnormal_chondrocyte_physiolo1.61826488
34MP0003690_abnormal_glial_cell1.60152863
35MP0005646_abnormal_pituitary_gland1.59611920
36MP0004019_abnormal_vitamin_homeostasis1.56311874
37MP0002118_abnormal_lipid_homeostasis1.55614597
38MP0001968_abnormal_touch/_nociception1.54444323
39MP0004043_abnormal_pH_regulation1.53218822
40MP0002638_abnormal_pupillary_reflex1.51128266
41MP0002734_abnormal_mechanical_nocicepti1.42966318
42MP0000566_synostosis1.39710077
43MP0000604_amyloidosis1.37964620
44MP0004885_abnormal_endolymph1.36954825
45MP0005584_abnormal_enzyme/coenzyme_acti1.35639923
46MP0001440_abnormal_grooming_behavior1.34752316
47MP0002653_abnormal_ependyma_morphology1.33193864
48MP0005535_abnormal_body_temperature1.28838491
49MP0003868_abnormal_feces_composition1.25294288
50MP0002733_abnormal_thermal_nociception1.21207041
51MP0003633_abnormal_nervous_system1.18965471
52MP0004924_abnormal_behavior1.16475167
53MP0005386_behavior/neurological_phenoty1.16475167
54MP0002067_abnormal_sensory_capabilities1.15761448
55MP0002152_abnormal_brain_morphology1.13211131
56MP0008569_lethality_at_weaning1.13185054
57MP0004742_abnormal_vestibular_system1.11670343
58MP0008872_abnormal_physiological_respon1.11318089
59MP0001485_abnormal_pinna_reflex1.07601364
60MP0000609_abnormal_liver_physiology1.07378541
61MP0003121_genomic_imprinting1.07005945
62MP0003191_abnormal_cellular_cholesterol1.07004443
63MP0002557_abnormal_social/conspecific_i1.06231735
64MP0001905_abnormal_dopamine_level1.05405791
65MP0002249_abnormal_larynx_morphology1.05224008
66MP0004142_abnormal_muscle_tone1.04992075
67MP0002736_abnormal_nociception_after1.04487650
68MP0006276_abnormal_autonomic_nervous1.04244073
69MP0004858_abnormal_nervous_system1.04057628
70MP0002876_abnormal_thyroid_physiology1.03218677
71MP0001970_abnormal_pain_threshold1.01709550
72MP0001984_abnormal_olfaction1.01698610
73MP0008874_decreased_physiological_sensi1.01551993
74MP0001963_abnormal_hearing_physiology1.01332083
75MP0003879_abnormal_hair_cell1.00290962
76MP0005319_abnormal_enzyme/_coenzyme0.99054063
77MP0005167_abnormal_blood-brain_barrier0.97550972
78MP0003631_nervous_system_phenotype0.95378145
79MP0003075_altered_response_to0.95266631
80MP0002066_abnormal_motor_capabilities/c0.94592495
81MP0003123_paternal_imprinting0.94500835
82MP0008961_abnormal_basal_metabolism0.92942909
83MP0000026_abnormal_inner_ear0.92702471
84MP0004811_abnormal_neuron_physiology0.92491595
85MP0002138_abnormal_hepatobiliary_system0.89441678
86MP0002078_abnormal_glucose_homeostasis0.88448195
87MP0005187_abnormal_penis_morphology0.88091375
88MP0000955_abnormal_spinal_cord0.87883652
89MP0002735_abnormal_chemical_nociception0.87704226
90MP0002069_abnormal_eating/drinking_beha0.87525564
91MP0001502_abnormal_circadian_rhythm0.86930058
92MP0000631_abnormal_neuroendocrine_gland0.85695306
93MP0001177_atelectasis0.85580738
94MP0004130_abnormal_muscle_cell0.83150815
95MP0009643_abnormal_urine_homeostasis0.81846431
96MP0005645_abnormal_hypothalamus_physiol0.81745498
97MP0000013_abnormal_adipose_tissue0.81296674
98MP0001764_abnormal_homeostasis0.79298917
99MP0002837_dystrophic_cardiac_calcinosis0.78916365
100MP0004133_heterotaxia0.78193963
101MP0002229_neurodegeneration0.77400243
102MP0002752_abnormal_somatic_nervous0.77266078
103MP0002090_abnormal_vision0.76648343
104MP0001529_abnormal_vocalization0.75212755
105MP0003632_abnormal_nervous_system0.74155962
106MP0000920_abnormal_myelination0.73737461
107MP0003283_abnormal_digestive_organ0.73647929
108MP0005636_abnormal_mineral_homeostasis0.73508374
109MP0002184_abnormal_innervation0.73480446
110MP0001765_abnormal_ion_homeostasis0.72484676
111MP0000639_abnormal_adrenal_gland0.72453087
112MP0005448_abnormal_energy_balance0.71910187
113MP0005248_abnormal_Harderian_gland0.71811392
114MP0002882_abnormal_neuron_morphology0.68647904
115MP0003953_abnormal_hormone_level0.68370507
116MP0000778_abnormal_nervous_system0.68205686
117MP0003861_abnormal_nervous_system0.67794270
118MP0005551_abnormal_eye_electrophysiolog0.66737779
119MP0005409_darkened_coat_color0.66275075
120MP0001756_abnormal_urination0.65221403
121MP0001986_abnormal_taste_sensitivity0.64315827
122MP0003938_abnormal_ear_development0.62211594
123MP0003183_abnormal_peptide_metabolism0.61946128
124MP0000230_abnormal_systemic_arterial0.60619858
125MP0005253_abnormal_eye_physiology0.60290095
126MP0003634_abnormal_glial_cell0.58366708

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.19668657
2Deep venous thrombosis (HP:0002625)5.08199467
3Intrahepatic cholestasis (HP:0001406)4.81747209
4Myokymia (HP:0002411)4.37292545
5Xanthomatosis (HP:0000991)4.34092034
6Focal motor seizures (HP:0011153)4.19758716
7Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19356338
8Prolonged partial thromboplastin time (HP:0003645)4.03765534
9Hypobetalipoproteinemia (HP:0003563)4.01787513
10Hyperlipoproteinemia (HP:0010980)3.75923085
11Ketosis (HP:0001946)3.63010469
12Complement deficiency (HP:0004431)3.45664268
13Hyperglycinemia (HP:0002154)3.44790942
14Hyperammonemia (HP:0001987)3.33422714
15Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28209111
16Abnormality of glycine metabolism (HP:0010895)3.18360689
17Abnormality of serine family amino acid metabolism (HP:0010894)3.18360689
18Diplopia (HP:0000651)3.18338406
19Abnormality of binocular vision (HP:0011514)3.18338406
20Focal seizures (HP:0007359)3.17971261
21Limb dystonia (HP:0002451)3.16696942
22Polyphagia (HP:0002591)3.15862256
23Gout (HP:0001997)3.15749284
24Hyperglycinuria (HP:0003108)3.14787750
25Epidermoid cyst (HP:0200040)3.14419009
26Status epilepticus (HP:0002133)3.12801350
27Ketoacidosis (HP:0001993)3.12299675
28Hemiparesis (HP:0001269)3.11055383
29Hypolipoproteinemia (HP:0010981)3.00787978
30Visual hallucinations (HP:0002367)2.95178348
31Delayed CNS myelination (HP:0002188)2.92137807
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.84799689
33Abnormality of the corticospinal tract (HP:0002492)2.84527087
34Abnormality of the common coagulation pathway (HP:0010990)2.82947703
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.78532778
36Action tremor (HP:0002345)2.72253546
37Epileptiform EEG discharges (HP:0011182)2.70567236
38Torticollis (HP:0000473)2.69895939
39Hypoalphalipoproteinemia (HP:0003233)2.67083103
40Joint hemorrhage (HP:0005261)2.65981946
41Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.65607233
42Hyperventilation (HP:0002883)2.65297542
43Hypoglycemic coma (HP:0001325)2.64638540
44Generalized tonic-clonic seizures (HP:0002069)2.64189514
45Megalencephaly (HP:0001355)2.59837573
46Conjugated hyperbilirubinemia (HP:0002908)2.59098998
47Fat malabsorption (HP:0002630)2.55606654
48EEG with generalized epileptiform discharges (HP:0011198)2.54328288
49Focal dystonia (HP:0004373)2.52639976
50Craniofacial dystonia (HP:0012179)2.49175751
51Abnormality of methionine metabolism (HP:0010901)2.47824291
52Morphological abnormality of the pyramidal tract (HP:0002062)2.46484120
53Absence seizures (HP:0002121)2.46427177
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.45442825
55Degeneration of the lateral corticospinal tracts (HP:0002314)2.45442825
56Impaired social interactions (HP:0000735)2.44313423
57Abnormal social behavior (HP:0012433)2.44313423
58Postural instability (HP:0002172)2.42647149
59Tetraplegia (HP:0002445)2.39359936
60Neurofibrillary tangles (HP:0002185)2.39265549
61Neonatal onset (HP:0003623)2.38430840
62Dysdiadochokinesis (HP:0002075)2.38183775
63Anxiety (HP:0000739)2.37657425
64Intention tremor (HP:0002080)2.37633324
65Abnormality of the lower motor neuron (HP:0002366)2.36482766
66Sensorimotor neuropathy (HP:0007141)2.35608491
67Abnormality of the intrinsic pathway (HP:0010989)2.31609476
68Hyperbilirubinemia (HP:0002904)2.31419291
69Truncal ataxia (HP:0002078)2.30077689
70Alkalosis (HP:0001948)2.28078482
71Split foot (HP:0001839)2.26955480
72Abnormal eating behavior (HP:0100738)2.26587875
73Abnormality of purine metabolism (HP:0004352)2.25925958
74Progressive cerebellar ataxia (HP:0002073)2.25563092
75Sleep apnea (HP:0010535)2.25497111
76Atonic seizures (HP:0010819)2.24495983
77Impaired vibration sensation in the lower limbs (HP:0002166)2.24311181
78Hypercholesterolemia (HP:0003124)2.23999433
79Supranuclear gaze palsy (HP:0000605)2.22510553
80Abnormality of complement system (HP:0005339)2.21094123
81Poor eye contact (HP:0000817)2.19166573
82Skin nodule (HP:0200036)2.18532268
83Depression (HP:0000716)2.18385630
84Dialeptic seizures (HP:0011146)2.17500475
85Hypoglycemic seizures (HP:0002173)2.15782859
86Urinary urgency (HP:0000012)2.15112200
87Drooling (HP:0002307)2.15105526
88Epileptic encephalopathy (HP:0200134)2.14161975
89Akinesia (HP:0002304)2.13768034
90Papilledema (HP:0001085)2.13113423
91Genetic anticipation (HP:0003743)2.12285124
92Scanning speech (HP:0002168)2.12152885
93Cerebral inclusion bodies (HP:0100314)2.11422553
94Irritability (HP:0000737)2.10986442
95Hemiplegia (HP:0002301)2.10308257
96Abnormal gallbladder physiology (HP:0012438)2.08864261
97Cholecystitis (HP:0001082)2.08864261
98Ankle clonus (HP:0011448)2.07845990
99Increased circulating renin level (HP:0000848)2.07758822
100Abnormality of fatty-acid metabolism (HP:0004359)2.06094841
101Bronchomalacia (HP:0002780)2.05871484
102Amblyopia (HP:0000646)2.05558268
103Abnormality of the diencephalon (HP:0010662)2.04955034
104Confusion (HP:0001289)2.04751905
105Abnormality of nucleobase metabolism (HP:0010932)2.03597874
106Pheochromocytoma (HP:0002666)2.03141926
107Dysmetria (HP:0001310)2.02638183
108Hepatoblastoma (HP:0002884)2.01813273
109Metabolic acidosis (HP:0001942)2.01312414
110Mutism (HP:0002300)1.99354739
111Abnormal gallbladder morphology (HP:0012437)1.98566430
112Spontaneous abortion (HP:0005268)1.98204334
113Peripheral hypomyelination (HP:0007182)1.97628177
114Mitral stenosis (HP:0001718)1.96499563
115Glomerulonephritis (HP:0000099)1.96491713
116Abnormality of serum amino acid levels (HP:0003112)1.96430447
117Spastic diplegia (HP:0001264)1.95966487
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95362279
119Cholelithiasis (HP:0001081)1.95206442
120Excessive salivation (HP:0003781)1.93407054
121Febrile seizures (HP:0002373)1.92843615
122Gaze-evoked nystagmus (HP:0000640)1.90502291
123Blue irides (HP:0000635)1.89498441
124Urinary bladder sphincter dysfunction (HP:0002839)1.89340471
125Agitation (HP:0000713)1.88039500
126Hyperinsulinemic hypoglycemia (HP:0000825)1.87610858
127Hypsarrhythmia (HP:0002521)1.86799748
128Spastic gait (HP:0002064)1.86218781
129Increased purine levels (HP:0004368)1.86213226
130Hyperuricemia (HP:0002149)1.86213226
131Turricephaly (HP:0000262)1.86058338
132Clonus (HP:0002169)1.83013848
133Gait imbalance (HP:0002141)1.80890647
134Broad-based gait (HP:0002136)1.80877155
135Obstructive sleep apnea (HP:0002870)1.76573705
136Lower limb muscle weakness (HP:0007340)1.76521973
137Absent speech (HP:0001344)1.75738120
138Impaired vibratory sensation (HP:0002495)1.75160344
139Aplasia involving bones of the extremities (HP:0009825)1.73477443
140Aplasia involving bones of the upper limbs (HP:0009823)1.73477443
141Aplasia of the phalanges of the hand (HP:0009802)1.73477443
142Oligodactyly (hands) (HP:0001180)1.73450180
143Arthropathy (HP:0003040)1.71443099
144Systemic lupus erythematosus (HP:0002725)1.67282075
145Bifid scrotum (HP:0000048)1.63581400
146Neuroendocrine neoplasm (HP:0100634)1.63320925
147Hypoplasia of the corpus callosum (HP:0002079)1.60594717
148Bradykinesia (HP:0002067)1.60160233

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.05929325
2NTRK33.65842886
3MAP3K92.97565171
4MAP3K42.82428953
5MAP2K42.58991669
6DAPK22.51312243
7MARK12.29240808
8MINK12.20211183
9NTRK22.08999348
10NTRK12.02134398
11MAP2K72.02025798
12CAMKK11.99722222
13KSR21.98294982
14PRKD31.95024759
15PAK61.93641307
16BCKDK1.79200164
17STK381.61553286
18PINK11.60623802
19SGK2231.52360201
20SGK4941.52360201
21WNK31.34891708
22OXSR11.34005593
23INSRR1.33461308
24MAP3K21.31925235
25SIK11.30416944
26SGK21.30151821
27SGK31.29828232
28CDK51.27264425
29PRKCG1.23069185
30NEK61.20772394
31TYRO31.17763550
32PRKCH1.14970873
33DYRK21.14634026
34LMTK21.14310186
35WNK41.13092806
36EPHA31.12825942
37MAPK151.09817098
38DYRK1A1.09676972
39ERBB41.08726865
40KSR11.07096684
41ARAF1.05105434
42CAMKK21.01245536
43MAP3K121.01173562
44RET1.01019768
45FES1.00207236
46TRIB30.98753758
47TNIK0.98727051
48FGFR20.98124317
49PHKG20.96659299
50PHKG10.96659299
51MAP3K130.96524462
52PIK3CA0.96493245
53GRK50.95739144
54TAOK10.93606005
55RIPK10.93223011
56PAK30.92581475
57PKN10.88822131
58DAPK10.88469278
59FGFR40.87225934
60UHMK10.86687621
61WNK10.85418804
62PDPK10.85271056
63STK110.84374407
64SIK20.83485760
65PRKCZ0.82521956
66NEK10.81260486
67CAMK2G0.78622946
68CAMK2A0.78408920
69MAP3K10.78236620
70MAP3K70.76204082
71MARK20.74887336
72RIPK40.74007585
73PDK10.72721086
74CAMK2D0.72581888
75LATS20.71525222
76FGFR30.70724226
77SGK10.69956050
78BCR0.69112071
79CAMK1G0.68866812
80CSNK1G20.67378097
81PRPF4B0.66937622
82TNK20.66543488
83CAMK10.62945725
84CAMK2B0.60718084
85RPS6KA30.60679919
86MAPK100.59968230
87PRKACG0.59841352
88MAPK130.57547631
89ROCK20.57380863
90CDK150.55824928
91PRKCE0.55487841
92CSNK1D0.54006520
93CDK180.53707861
94ALK0.52757736
95CDC42BPA0.52408096
96DYRK1B0.52135022
97ERBB20.51896429
98CDK140.51182054
99FRK0.50921128
100PRKAA10.50852571
101STK390.50323022
102MAP2K10.50167352
103CAMK40.49995581
104ICK0.47406909
105PTK60.47306081
106TAOK30.47261272
107PRKG10.46890578
108RPS6KB10.46669667
109ROCK10.46187811
110CSNK1G30.45789689
111JAK20.45668352
112PNCK0.44520382
113CSNK1G10.44334562
114PKN20.43897389
115PLK20.43738538
116CASK0.43355206
117CDK11A0.42988583
118CDK190.42588103
119PDK30.42341733
120PDK40.42341733
121CAMK1D0.42293796
122PDGFRA0.40655015
123SCYL20.40517389
124CSNK1A1L0.39972240
125PRKACA0.38811298
126CSNK1A10.38130302
127CSNK1E0.38101686

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.55483578
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.37806056
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.17183658
4Arginine biosynthesis_Homo sapiens_hsa002202.82718728
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.42222221
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34657181
7* Butanoate metabolism_Homo sapiens_hsa006502.19986687
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12120850
9Tryptophan metabolism_Homo sapiens_hsa003802.05519926
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02361762
11Fatty acid degradation_Homo sapiens_hsa000711.88418669
12* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.87377594
13Bile secretion_Homo sapiens_hsa049761.86026826
14* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70961934
15Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.68892791
16Complement and coagulation cascades_Homo sapiens_hsa046101.62535368
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59032275
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.56634250
19Fatty acid metabolism_Homo sapiens_hsa012121.54359420
20Nicotine addiction_Homo sapiens_hsa050331.52359617
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51359390
22Synaptic vesicle cycle_Homo sapiens_hsa047211.48653229
23PPAR signaling pathway_Homo sapiens_hsa033201.44742285
24* GABAergic synapse_Homo sapiens_hsa047271.42258244
25Peroxisome_Homo sapiens_hsa041461.41291451
26Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36963953
27* Propanoate metabolism_Homo sapiens_hsa006401.36531283
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.27410797
29Histidine metabolism_Homo sapiens_hsa003401.18670460
30Phenylalanine metabolism_Homo sapiens_hsa003601.16958245
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.16171746
32Pyruvate metabolism_Homo sapiens_hsa006201.14721835
33* beta-Alanine metabolism_Homo sapiens_hsa004101.14170577
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10875764
35Sulfur metabolism_Homo sapiens_hsa009201.09874392
36Chemical carcinogenesis_Homo sapiens_hsa052041.07740329
37Glutamatergic synapse_Homo sapiens_hsa047241.04173749
38Olfactory transduction_Homo sapiens_hsa047401.03762542
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01290247
40Circadian entrainment_Homo sapiens_hsa047131.00267372
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00172419
42Morphine addiction_Homo sapiens_hsa050320.99316928
43Linoleic acid metabolism_Homo sapiens_hsa005910.98535053
44Insulin secretion_Homo sapiens_hsa049110.95320178
45Tyrosine metabolism_Homo sapiens_hsa003500.95047472
46Amphetamine addiction_Homo sapiens_hsa050310.93269439
47Starch and sucrose metabolism_Homo sapiens_hsa005000.90843085
48Biosynthesis of amino acids_Homo sapiens_hsa012300.89098927
49Retinol metabolism_Homo sapiens_hsa008300.88797451
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.85601640
51Fatty acid elongation_Homo sapiens_hsa000620.84902799
52ABC transporters_Homo sapiens_hsa020100.84739430
53Carbon metabolism_Homo sapiens_hsa012000.84723557
54Axon guidance_Homo sapiens_hsa043600.84121394
55Cocaine addiction_Homo sapiens_hsa050300.83493472
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.82270553
57Salivary secretion_Homo sapiens_hsa049700.82034843
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.81354440
59Long-term potentiation_Homo sapiens_hsa047200.80673737
60Estrogen signaling pathway_Homo sapiens_hsa049150.80098780
61Caffeine metabolism_Homo sapiens_hsa002320.78619111
62Dopaminergic synapse_Homo sapiens_hsa047280.78364099
63Aldosterone synthesis and secretion_Homo sapiens_hsa049250.76172578
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75980960
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.75013600
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.73854089
67Gastric acid secretion_Homo sapiens_hsa049710.72243879
68Vitamin B6 metabolism_Homo sapiens_hsa007500.71466578
69Fatty acid biosynthesis_Homo sapiens_hsa000610.69991988
70Glycerolipid metabolism_Homo sapiens_hsa005610.68240511
71Fat digestion and absorption_Homo sapiens_hsa049750.67532427
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66423704
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66192437
74Staphylococcus aureus infection_Homo sapiens_hsa051500.65886174
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64382470
76Cholinergic synapse_Homo sapiens_hsa047250.63889740
77Selenocompound metabolism_Homo sapiens_hsa004500.63535771
78Arginine and proline metabolism_Homo sapiens_hsa003300.62173811
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62053618
80Type II diabetes mellitus_Homo sapiens_hsa049300.60792360
81Pancreatic secretion_Homo sapiens_hsa049720.59227830
82Taste transduction_Homo sapiens_hsa047420.58847678
83Melanogenesis_Homo sapiens_hsa049160.58646130
84Renin secretion_Homo sapiens_hsa049240.57802034
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57486193
86Steroid biosynthesis_Homo sapiens_hsa001000.56554609
87Prion diseases_Homo sapiens_hsa050200.52131512
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51884719
89Lysine degradation_Homo sapiens_hsa003100.51149825
90Thyroid hormone synthesis_Homo sapiens_hsa049180.48237747
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47836864
92Vitamin digestion and absorption_Homo sapiens_hsa049770.47702551
93ErbB signaling pathway_Homo sapiens_hsa040120.46932273
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45303982
95Phototransduction_Homo sapiens_hsa047440.45190398
96Collecting duct acid secretion_Homo sapiens_hsa049660.45112233
97Long-term depression_Homo sapiens_hsa047300.44265986
98Glucagon signaling pathway_Homo sapiens_hsa049220.43642960
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43186201
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42647305
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.41725432
102Calcium signaling pathway_Homo sapiens_hsa040200.41677417
103Serotonergic synapse_Homo sapiens_hsa047260.40841280
104Dorso-ventral axis formation_Homo sapiens_hsa043200.40731430
105Glioma_Homo sapiens_hsa052140.39716779
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39528676
107cAMP signaling pathway_Homo sapiens_hsa040240.39239535
108Cardiac muscle contraction_Homo sapiens_hsa042600.38519841
109Choline metabolism in cancer_Homo sapiens_hsa052310.38209495
110Ovarian steroidogenesis_Homo sapiens_hsa049130.37290925
111AMPK signaling pathway_Homo sapiens_hsa041520.36911437
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.36898512
113Oxytocin signaling pathway_Homo sapiens_hsa049210.35146858
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.34422344
115Gap junction_Homo sapiens_hsa045400.33613095
116GnRH signaling pathway_Homo sapiens_hsa049120.32709250
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.30155786
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27969954
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26709694

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