ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cullin deneddylation (GO:0010388)	3.65974563
2	DNA double-strand break processing (GO:0000729)	3.57836496
3	peptidyl-histidine modification (GO:0018202)	3.52770241
4	non-recombinational repair (GO:0000726)	3.44965671
5	double-strand break repair via nonhomologous end joining (GO:0006303)	3.44965671
6	respiratory chain complex IV assembly (GO:0008535)	3.39669154
7	regulation of centriole replication (GO:0046599)	3.32904930
8	protein deneddylation (GO:0000338)	3.31839681
9	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.26423588
10	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.26423588
11	negative regulation of fibroblast apoptotic process (GO:2000270)	3.14028362
12	DNA ligation (GO:0006266)	3.10230047
13	cytochrome complex assembly (GO:0017004)	3.06054918
14	proteasome assembly (GO:0043248)	3.04111657
15	regulation of meiosis I (GO:0060631)	3.01966025
16	synapsis (GO:0007129)	2.98709961
17	intraciliary transport (GO:0042073)	2.98650451
18	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.97330632
19	mitotic sister chromatid cohesion (GO:0007064)	2.96896972
20	chromatin remodeling at centromere (GO:0031055)	2.95653246
21	lactate metabolic process (GO:0006089)	2.91712593
22	histone H2A acetylation (GO:0043968)	2.91120418
23	CENP-A containing nucleosome assembly (GO:0034080)	2.90736857
24	ribosome assembly (GO:0042255)	2.87374995
25	mitotic metaphase plate congression (GO:0007080)	2.85856438
26	metaphase plate congression (GO:0051310)	2.85399699
27	protein-cofactor linkage (GO:0018065)	2.85305008
28	establishment of integrated proviral latency (GO:0075713)	2.84219216
29	DNA replication-dependent nucleosome organization (GO:0034723)	2.81922351
30	DNA replication-dependent nucleosome assembly (GO:0006335)	2.81922351
31	postreplication repair (GO:0006301)	2.81151633
32	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	2.78767729
33	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	2.78767729
34	positive regulation of mitotic sister chromatid separation (GO:1901970)	2.78767729
35	replication fork processing (GO:0031297)	2.77784788
36	C4-dicarboxylate transport (GO:0015740)	2.75743521
37	regulation of DNA endoreduplication (GO:0032875)	2.75221569
38	regulation of sister chromatid cohesion (GO:0007063)	2.74818042
39	kinetochore organization (GO:0051383)	2.74428917
40	retinal ganglion cell axon guidance (GO:0031290)	2.74225943
41	mitotic sister chromatid segregation (GO:0000070)	2.73644555
42	negative regulation of DNA recombination (GO:0045910)	2.67230869
43	nucleotide-excision repair, DNA gap filling (GO:0006297)	2.67177035
44	sister chromatid segregation (GO:0000819)	2.67067382
45	resolution of meiotic recombination intermediates (GO:0000712)	2.66978179
46	kinetochore assembly (GO:0051382)	2.66278014
47	transcription from mitochondrial promoter (GO:0006390)	2.66061959
48	histone exchange (GO:0043486)	2.65091104
49	DNA catabolic process, exonucleolytic (GO:0000738)	2.62066415
50	regulation of centrosome duplication (GO:0010824)	2.61688995
51	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.59643099
52	purine nucleobase biosynthetic process (GO:0009113)	2.58840343
53	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.58034200
54	nonmotile primary cilium assembly (GO:0035058)	2.55960860
55	mitochondrial RNA metabolic process (GO:0000959)	2.53211789
56	regulation of centrosome cycle (GO:0046605)	2.53202743
57	protein neddylation (GO:0045116)	2.52500345
58	attachment of spindle microtubules to kinetochore (GO:0008608)	2.50913717
59	spindle checkpoint (GO:0031577)	2.50718257
60	pseudouridine synthesis (GO:0001522)	2.50080876
61	lipid particle organization (GO:0034389)	2.46503197
62	DNA replication-independent nucleosome organization (GO:0034724)	2.44343963
63	DNA replication-independent nucleosome assembly (GO:0006336)	2.44343963
64	IMP biosynthetic process (GO:0006188)	2.43316021
65	protein prenylation (GO:0018342)	2.42903846
66	prenylation (GO:0097354)	2.42903846
67	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.42173572
68	cilium morphogenesis (GO:0060271)	2.40856675
69	protein K6-linked ubiquitination (GO:0085020)	2.40308270
70	mitotic spindle checkpoint (GO:0071174)	2.39281979
71	regulation of mitochondrial translation (GO:0070129)	2.38779618
72	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.37368422
73	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.37368422
74	isotype switching (GO:0045190)	2.37368422
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.36952502
76	positive regulation of mRNA processing (GO:0050685)	2.35338048
77	regulation of chromosome segregation (GO:0051983)	2.34397404
78	maturation of 5.8S rRNA (GO:0000460)	2.34392188
79	regulation of feeding behavior (GO:0060259)	2.33760448
80	translesion synthesis (GO:0019985)	2.33545196
81	protein heterotetramerization (GO:0051290)	2.33430434
82	recombinational repair (GO:0000725)	2.32930686
83	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.32846628
84	regulation of mitotic spindle checkpoint (GO:1903504)	2.32846628
85	inositol phosphate catabolic process (GO:0071545)	2.32155099
86	establishment of chromosome localization (GO:0051303)	2.32014699
87	telomere maintenance via semi-conservative replication (GO:0032201)	2.31599263
88	double-strand break repair via homologous recombination (GO:0000724)	2.30618457
89	mitotic recombination (GO:0006312)	2.29088119
90	microtubule depolymerization (GO:0007019)	2.28626372
91	regulation of mRNA 3-end processing (GO:0031440)	2.28599238
92	DNA strand elongation involved in DNA replication (GO:0006271)	2.28536684
93	regulation of mitotic spindle organization (GO:0060236)	2.27936869
94	regulation of helicase activity (GO:0051095)	2.27850225
95	telomere maintenance via telomerase (GO:0007004)	2.27090529
96	positive regulation of histone H3-K4 methylation (GO:0051571)	2.26959323
97	response to nitrosative stress (GO:0051409)	2.26452556
98	fatty acid elongation (GO:0030497)	2.26411288
99	keratinocyte development (GO:0003334)	2.26390141
100	regulation of metaphase/anaphase transition of cell cycle (GO:1902099)	2.26161140

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.93589483
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.79543732
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.31937067
4	E2F7_22180533_ChIP-Seq_HELA_Human	2.84446165
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.80315571
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.67048221
7	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.60978461
8	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.53595757
9	TAF15_26573619_Chip-Seq_HEK293_Human	2.45519444
10	* ZNF274_21170338_ChIP-Seq_K562_Hela	2.40255533
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.35216881
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.33608625
13	FUS_26573619_Chip-Seq_HEK293_Human	2.31875087
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24901245
15	EWS_26573619_Chip-Seq_HEK293_Human	2.19139856
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18575952
17	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.17719231
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.14566153
19	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.11894764
20	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.11417269
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.10352097
22	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.94285257
23	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89974631
24	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.88737008
25	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.84314746
26	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.80931165
27	P300_19829295_ChIP-Seq_ESCs_Human	1.77549397
28	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77385637
29	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.77153285
30	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.74427502
31	VDR_22108803_ChIP-Seq_LS180_Human	1.66871678
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.66249511
33	GBX2_23144817_ChIP-Seq_PC3_Human	1.64625595
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.61168732
35	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.59792729
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59225335
37	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.59068550
38	* VDR_23849224_ChIP-Seq_CD4+_Human	1.50967167
39	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.49111652
40	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.47815590
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.47607508
42	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.44642063
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44271100
44	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.41407094
45	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.40185547
46	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.37798136
47	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.35773763
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33782099
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.33487018
50	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.33015438
51	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31893033
52	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.31305149
53	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.30120574
54	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.29554343
55	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.29492703
56	AR_21909140_ChIP-Seq_LNCAP_Human	1.29414444
57	CBP_20019798_ChIP-Seq_JUKART_Human	1.28668544
58	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.28668544
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.26069578
60	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23787913
61	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.21843952
62	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.20407317
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.19312623
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18364790
65	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.14543491
66	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.12346270
67	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.11957481
68	* STAT3_23295773_ChIP-Seq_U87_Human	1.08158453
69	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07740770
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07726933
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07411994
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.07366058
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07168898
74	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.06343053
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.06177495
76	MYC_18940864_ChIP-ChIP_HL60_Human	1.06040171
77	DCP1A_22483619_ChIP-Seq_HELA_Human	1.05238129
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04352542
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.02868305
80	AR_25329375_ChIP-Seq_VCAP_Human	1.02174071
81	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.00680483
82	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.99273930
83	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.99113000
84	TP53_22573176_ChIP-Seq_HFKS_Human	0.98548588
85	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97871806
86	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97076415
87	TCF4_22108803_ChIP-Seq_LS180_Human	0.96176391
88	* TCF4_23295773_ChIP-Seq_U87_Human	0.95776365
89	TTF2_22483619_ChIP-Seq_HELA_Human	0.94586534
90	SOX2_19829295_ChIP-Seq_ESCs_Human	0.93789278
91	NANOG_19829295_ChIP-Seq_ESCs_Human	0.93789278
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.92181987
93	SOX9_26525672_Chip-Seq_HEART_Mouse	0.91809741
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.91626162
95	NELFA_20434984_ChIP-Seq_ESCs_Mouse	0.91589690
96	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.91094559
97	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.91011525
98	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89901289
99	P53_22387025_ChIP-Seq_ESCs_Mouse	0.89187345
100	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.89084567

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008058_abnormal_DNA_repair	3.29007211
2	MP0008057_abnormal_DNA_replication	3.21484911
3	MP0010094_abnormal_chromosome_stability	3.00196614
4	MP0003693_abnormal_embryo_hatching	2.53239262
5	MP0005084_abnormal_gallbladder_morpholo	2.43681990
6	MP0008877_abnormal_DNA_methylation	2.36424808
7	MP0003121_genomic_imprinting	2.10680277
8	MP0003787_abnormal_imprinting	2.05605514
9	MP0004957_abnormal_blastocyst_morpholog	1.99314190
10	MP0003880_abnormal_central_pattern	1.92124919
11	MP0005367_renal/urinary_system_phenotyp	1.89142219
12	MP0000516_abnormal_urinary_system	1.89142219
13	MP0003111_abnormal_nucleus_morphology	1.87693356
14	MP0002837_dystrophic_cardiac_calcinosis	1.87677424
15	MP0003718_maternal_effect	1.80735774
16	MP0003122_maternal_imprinting	1.80685191
17	MP0001529_abnormal_vocalization	1.73258701
18	MP0006072_abnormal_retinal_apoptosis	1.72903206
19	MP0008932_abnormal_embryonic_tissue	1.71996851
20	MP0003077_abnormal_cell_cycle	1.71268500
21	MP0008789_abnormal_olfactory_epithelium	1.70253855
22	MP0003123_paternal_imprinting	1.69795301
23	MP0000647_abnormal_sebaceous_gland	1.62248027
24	MP0002938_white_spotting	1.59343044
25	MP0008007_abnormal_cellular_replicative	1.57455140
26	MP0002751_abnormal_autonomic_nervous	1.50597426
27	MP0010234_abnormal_vibrissa_follicle	1.50209793
28	MP0005187_abnormal_penis_morphology	1.50026534
29	MP0004147_increased_porphyrin_level	1.48407396
30	MP0009046_muscle_twitch	1.47297460
31	MP0006035_abnormal_mitochondrial_morpho	1.45506584
32	MP0002102_abnormal_ear_morphology	1.44914834
33	MP0006292_abnormal_olfactory_placode	1.43023354
34	MP0002638_abnormal_pupillary_reflex	1.41159482
35	MP0001188_hyperpigmentation	1.36576776
36	MP0003011_delayed_dark_adaptation	1.33700044
37	MP0000631_abnormal_neuroendocrine_gland	1.32778511
38	MP0000427_abnormal_hair_cycle	1.32286639
39	MP0002233_abnormal_nose_morphology	1.30409944
40	MP0003786_premature_aging	1.29849963
41	MP0003937_abnormal_limbs/digits/tail_de	1.29276480
42	MP0005220_abnormal_exocrine_pancreas	1.26390194
43	MP0009697_abnormal_copulation	1.26073761
44	MP0003195_calcinosis	1.22985728
45	MP0005253_abnormal_eye_physiology	1.21886382
46	MP0002736_abnormal_nociception_after	1.21506357
47	MP0009780_abnormal_chondrocyte_physiolo	1.17632501
48	MP0001929_abnormal_gametogenesis	1.15812959
49	MP0005248_abnormal_Harderian_gland	1.15693980
50	MP0006036_abnormal_mitochondrial_physio	1.12278489
51	MP0001984_abnormal_olfaction	1.12154515
52	MP0000569_abnormal_digit_pigmentation	1.11393467
53	MP0010678_abnormal_skin_adnexa	1.09887321
54	MP0004270_analgesia	1.09551502
55	MP0005379_endocrine/exocrine_gland_phen	1.08898449
56	MP0002160_abnormal_reproductive_system	1.06558076
57	MP0006276_abnormal_autonomic_nervous	1.05429779
58	MP0002163_abnormal_gland_morphology	1.05221839
59	MP0005551_abnormal_eye_electrophysiolog	1.04583235
60	MP0005394_taste/olfaction_phenotype	1.04534712
61	MP0005499_abnormal_olfactory_system	1.04534712
62	MP0001293_anophthalmia	1.04049472
63	MP0002184_abnormal_innervation	1.02288225
64	MP0000778_abnormal_nervous_system	1.00453209
65	MP0002090_abnormal_vision	0.97851044
66	MP0002210_abnormal_sex_determination	0.97302174
67	MP0008995_early_reproductive_senescence	0.95615253
68	MP0000653_abnormal_sex_gland	0.92716692
69	MP0004215_abnormal_myocardial_fiber	0.92315022
70	MP0004133_heterotaxia	0.90933206
71	MP0009703_decreased_birth_body	0.89747778
72	MP0001730_embryonic_growth_arrest	0.89469645
73	MP0003698_abnormal_male_reproductive	0.88673990
74	MP0003119_abnormal_digestive_system	0.85326806
75	MP0003861_abnormal_nervous_system	0.84952572
76	MP0001145_abnormal_male_reproductive	0.84378090
77	MP0005075_abnormal_melanosome_morpholog	0.83494932
78	MP0002084_abnormal_developmental_patter	0.82922855
79	MP0003755_abnormal_palate_morphology	0.82106414
80	MP0002272_abnormal_nervous_system	0.80281572
81	MP0001697_abnormal_embryo_size	0.80242587
82	MP0003943_abnormal_hepatobiliary_system	0.79099194
83	MP0003950_abnormal_plasma_membrane	0.79025744
84	MP0009745_abnormal_behavioral_response	0.78397009
85	MP0001299_abnormal_eye_distance/	0.78371038
86	MP0002909_abnormal_adrenal_gland	0.78325803
87	MP0001968_abnormal_touch/_nociception	0.77818768
88	MP0000358_abnormal_cell_content/	0.75130922
89	MP0010329_abnormal_lipoprotein_level	0.75081422
90	MP0000613_abnormal_salivary_gland	0.74656425
91	MP0004924_abnormal_behavior	0.73502537
92	MP0005386_behavior/neurological_phenoty	0.73502537
93	MP0002557_abnormal_social/conspecific_i	0.73134003
94	MP0001661_extended_life_span	0.72500151
95	MP0000955_abnormal_spinal_cord	0.70258119
96	MP0002234_abnormal_pharynx_morphology	0.69972536
97	MP0010307_abnormal_tumor_latency	0.69184542
98	MP0002085_abnormal_embryonic_tissue	0.68988182
99	MP0004811_abnormal_neuron_physiology	0.67970736
100	MP0005391_vision/eye_phenotype	0.66733866

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	3.12702835
2	Pancreatic fibrosis (HP:0100732)	3.09650510
3	Hypoglycemic coma (HP:0001325)	2.98099089
4	Pancreatic cysts (HP:0001737)	2.93857143
5	Neoplasm of the adrenal cortex (HP:0100641)	2.84386279
6	Rhabdomyosarcoma (HP:0002859)	2.82931567
7	Abnormality of the labia minora (HP:0012880)	2.80822412
8	Medial flaring of the eyebrow (HP:0010747)	2.77522167
9	Pancreatic islet-cell hyperplasia (HP:0004510)	2.60800828
10	Neoplasm of the adrenal gland (HP:0100631)	2.59691924
11	Congenital primary aphakia (HP:0007707)	2.49527226
12	Nephronophthisis (HP:0000090)	2.49498422
13	Hypoglycemic seizures (HP:0002173)	2.48846531
14	Volvulus (HP:0002580)	2.47972874
15	Unilateral renal agenesis (HP:0000122)	2.45746499
16	Gait imbalance (HP:0002141)	2.45723155
17	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.42287223
18	Hypothermia (HP:0002045)	2.41750299
19	Glioma (HP:0009733)	2.41117520
20	Intestinal atresia (HP:0011100)	2.40406510
21	Chromsome breakage (HP:0040012)	2.36049759
22	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.35179276
23	Meckel diverticulum (HP:0002245)	2.30402742
24	Colon cancer (HP:0003003)	2.30022732
25	Abnormality of chromosome stability (HP:0003220)	2.28194955
26	Hepatoblastoma (HP:0002884)	2.27303430
27	Hyperinsulinemic hypoglycemia (HP:0000825)	2.27114584
28	Abnormality of the ileum (HP:0001549)	2.25475358
29	Ependymoma (HP:0002888)	2.24096171
30	Long clavicles (HP:0000890)	2.23384695
31	Papillary thyroid carcinoma (HP:0002895)	2.21588580
32	Tubulointerstitial nephritis (HP:0001970)	2.21405019
33	Abnormality of endocrine pancreas physiology (HP:0012093)	2.20200907
34	Abnormality of the pancreatic islet cells (HP:0006476)	2.20200907
35	Nephrogenic diabetes insipidus (HP:0009806)	2.16764300
36	Abnormality of methionine metabolism (HP:0010901)	2.15156785
37	Medulloblastoma (HP:0002885)	2.13702919
38	Methylmalonic acidemia (HP:0002912)	2.10957789
39	Renal cortical cysts (HP:0000803)	2.09469389
40	Progressive inability to walk (HP:0002505)	2.09409589
41	Abnormality of the astrocytes (HP:0100707)	2.08220159
42	Astrocytoma (HP:0009592)	2.08220159
43	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.08205812
44	Sloping forehead (HP:0000340)	2.06749412
45	Chronic hepatic failure (HP:0100626)	2.04761909
46	Ketoacidosis (HP:0001993)	2.03421616
47	Genital tract atresia (HP:0001827)	2.02135539
48	Supernumerary spleens (HP:0009799)	2.01160964
49	Thyroid carcinoma (HP:0002890)	1.99140289
50	Gonadotropin excess (HP:0000837)	1.97047148
51	Molar tooth sign on MRI (HP:0002419)	1.97045159
52	Abnormality of midbrain morphology (HP:0002418)	1.97045159
53	Abnormality of the renal medulla (HP:0100957)	1.96760644
54	Symptomatic seizures (HP:0011145)	1.96691303
55	Abnormal lung lobation (HP:0002101)	1.91331889
56	Birth length less than 3rd percentile (HP:0003561)	1.89696402
57	Sclerocornea (HP:0000647)	1.89340898
58	Neoplasm of striated muscle (HP:0009728)	1.88406126
59	Vaginal atresia (HP:0000148)	1.86120305
60	Muscular hypotonia of the trunk (HP:0008936)	1.84739379
61	Abnormality of the metopic suture (HP:0005556)	1.84391392
62	Abnormality of the preputium (HP:0100587)	1.83389923
63	Occipital encephalocele (HP:0002085)	1.82364987
64	Broad foot (HP:0001769)	1.81695180
65	Horizontal nystagmus (HP:0000666)	1.79291299
66	Anencephaly (HP:0002323)	1.79109637
67	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79085504
68	Breast carcinoma (HP:0003002)	1.78817336
69	Septo-optic dysplasia (HP:0100842)	1.78148754
70	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.77168645
71	Metaphyseal dysplasia (HP:0100255)	1.76929321
72	Spastic diplegia (HP:0001264)	1.76260807
73	Postaxial hand polydactyly (HP:0001162)	1.75640313
74	Astigmatism (HP:0000483)	1.75060797
75	Adrenal hypoplasia (HP:0000835)	1.74164169
76	Furrowed tongue (HP:0000221)	1.73673181
77	Abnormality of vitamin B metabolism (HP:0004340)	1.72129356
78	Decreased testicular size (HP:0008734)	1.70188473
79	Abnormality of the renal cortex (HP:0011035)	1.69767622
80	Abnormality of the duodenum (HP:0002246)	1.68667677
81	Absent eyebrow (HP:0002223)	1.68511544
82	Poor coordination (HP:0002370)	1.68240624
83	Nephroblastoma (Wilms tumor) (HP:0002667)	1.68064507
84	Postaxial foot polydactyly (HP:0001830)	1.67601705
85	Neuroendocrine neoplasm (HP:0100634)	1.66519855
86	Hyperglycinemia (HP:0002154)	1.66044801
87	Oculomotor apraxia (HP:0000657)	1.62815116
88	Small intestinal stenosis (HP:0012848)	1.62653205
89	Duodenal stenosis (HP:0100867)	1.62653205
90	Hepatic necrosis (HP:0002605)	1.62272261
91	Prominent metopic ridge (HP:0005487)	1.61673524
92	Dandy-Walker malformation (HP:0001305)	1.60823406
93	Abnormality of the septum pellucidum (HP:0007375)	1.60679137
94	Bile duct proliferation (HP:0001408)	1.58859336
95	Abnormal biliary tract physiology (HP:0012439)	1.58859336
96	Embryonal renal neoplasm (HP:0011794)	1.58424721
97	Disproportionate short-trunk short stature (HP:0003521)	1.56994817
98	Exercise-induced muscle cramps (HP:0003710)	1.55528629
99	Optic nerve hypoplasia (HP:0000609)	1.54900478
100	Cystic liver disease (HP:0006706)	1.54454255

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	3.18880865
2	FRK	3.00482887
3	SRPK1	2.84865778
4	TSSK6	2.77913550
5	CASK	2.71955688
6	ZAK	2.71541703
7	MKNK1	2.63287107
8	EIF2AK3	2.53087159
9	MAP3K4	2.51746746
10	BUB1	2.36164853
11	WNK3	2.35528229
12	PLK3	2.15740153
13	TTK	2.03295502
14	TRIM28	1.96692415
15	BRSK2	1.88802503
16	EIF2AK1	1.83735386
17	PLK4	1.75456899
18	ERBB3	1.73774557
19	DYRK3	1.69125941
20	NUAK1	1.65604907
21	WEE1	1.60945900
22	MST4	1.59633768
23	CSNK1G1	1.57540736
24	PLK2	1.54995069
25	MARK1	1.53189087
26	CCNB1	1.46130244
27	CSNK1G3	1.45351938
28	NEK1	1.42844344
29	TNIK	1.40891678
30	PBK	1.40760451
31	CSNK1G2	1.38287542
32	BRD4	1.38105101
33	CDC7	1.36452969
34	BMPR1B	1.31341492
35	PLK1	1.29565987
36	MUSK	1.28094431
37	STK38L	1.27264594
38	MAP4K2	1.26409154
39	PNCK	1.22297481
40	MAP2K7	1.21184273
41	BCR	1.15308794
42	CSNK1A1L	1.14849174
43	MAP3K12	1.07665800
44	RPS6KA4	1.05947798
45	PINK1	1.05279315
46	STK39	1.04532014
47	TAF1	1.01999090
48	FER	1.01718955
49	STK24	1.00412453
50	PHKG2	0.99580909
51	PHKG1	0.99580909
52	ATR	0.96889271
53	AKT3	0.95439841
54	ERBB4	0.94547050
55	STK16	0.93103178
56	INSRR	0.90975807
57	FGFR2	0.87947798
58	PRKCE	0.85583097
59	VRK1	0.85001145
60	PRKCG	0.82386679
61	EPHA4	0.81992501
62	GRK1	0.79101992
63	SCYL2	0.78818399
64	MAPK13	0.76638752
65	BRSK1	0.74527740
66	NTRK3	0.74367766
67	OBSCN	0.72699947
68	ATM	0.72511981
69	CHEK2	0.66729171
70	DYRK2	0.60602950
71	PASK	0.58237629
72	AURKB	0.54940501
73	DYRK1A	0.54804598
74	EIF2AK2	0.54760163
75	PAK3	0.50348091
76	SGK2	0.48947217
77	CSNK1D	0.47506224
78	WNK4	0.47284596
79	CHEK1	0.46747353
80	STK3	0.46169655
81	NLK	0.45764302
82	DAPK1	0.43832240
83	VRK2	0.42318663
84	OXSR1	0.41793141
85	PRKD3	0.38687693
86	CSNK1E	0.38234505
87	PRKDC	0.37350130
88	PKN1	0.37339667
89	YES1	0.35074610
90	CDK3	0.34559880
91	CDK1	0.34306234
92	CSNK1A1	0.33534567
93	NME1	0.33384588
94	CAMK2A	0.33372109
95	ACVR1B	0.32461675
96	FLT3	0.32398427
97	CSNK2A1	0.29802994
98	PRKAA1	0.29723824
99	RPS6KB1	0.29537358
100	FGFR1	0.28670321

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Non-homologous end-joining_Homo sapiens_hsa03450	3.23823717
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90778558
3	Protein export_Homo sapiens_hsa03060	2.70094919
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.58107314
5	Propanoate metabolism_Homo sapiens_hsa00640	2.51860527
6	Mismatch repair_Homo sapiens_hsa03430	2.42617020
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.36180543
8	Proteasome_Homo sapiens_hsa03050	2.32815515
9	Basal transcription factors_Homo sapiens_hsa03022	2.16281388
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.08935826
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08401341
12	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.05338099
13	Fatty acid elongation_Homo sapiens_hsa00062	2.04498259
14	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02080243
15	RNA polymerase_Homo sapiens_hsa03020	1.97511720
16	Homologous recombination_Homo sapiens_hsa03440	1.89515943
17	Butanoate metabolism_Homo sapiens_hsa00650	1.88036792
18	DNA replication_Homo sapiens_hsa03030	1.82456349
19	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.80959969
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.71882714
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.68883268
22	Nucleotide excision repair_Homo sapiens_hsa03420	1.65267624
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.65217827
24	RNA transport_Homo sapiens_hsa03013	1.60564836
25	Base excision repair_Homo sapiens_hsa03410	1.54942464
26	Selenocompound metabolism_Homo sapiens_hsa00450	1.53249968
27	Cell cycle_Homo sapiens_hsa04110	1.52064252
28	RNA degradation_Homo sapiens_hsa03018	1.43520759
29	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.33991484
30	Oocyte meiosis_Homo sapiens_hsa04114	1.32727516
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31901170
32	Pyruvate metabolism_Homo sapiens_hsa00620	1.31318326
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.29628540
34	Spliceosome_Homo sapiens_hsa03040	1.25320833
35	Circadian rhythm_Homo sapiens_hsa04710	1.20022863
36	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13600691
37	Nicotine addiction_Homo sapiens_hsa05033	1.09361516
38	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.07528586
39	Purine metabolism_Homo sapiens_hsa00230	1.07161104
40	Phototransduction_Homo sapiens_hsa04744	1.07158946
41	Oxidative phosphorylation_Homo sapiens_hsa00190	1.06305423
42	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.05771770
43	Fatty acid metabolism_Homo sapiens_hsa01212	1.03037376
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.02602070
45	One carbon pool by folate_Homo sapiens_hsa00670	1.02537568
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.99895823
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.99457222
48	Folate biosynthesis_Homo sapiens_hsa00790	0.97009436
49	p53 signaling pathway_Homo sapiens_hsa04115	0.92615537
50	beta-Alanine metabolism_Homo sapiens_hsa00410	0.89681505
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89488724
52	mRNA surveillance pathway_Homo sapiens_hsa03015	0.86764200
53	Peroxisome_Homo sapiens_hsa04146	0.86542953
54	Huntingtons disease_Homo sapiens_hsa05016	0.86199497
55	Parkinsons disease_Homo sapiens_hsa05012	0.85723769
56	Lysine degradation_Homo sapiens_hsa00310	0.84336370
57	Fatty acid degradation_Homo sapiens_hsa00071	0.83592005
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.82686674
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.82280688
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.80862821
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.78568016
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74793269
63	Regulation of autophagy_Homo sapiens_hsa04140	0.69964967
64	Sphingolipid metabolism_Homo sapiens_hsa00600	0.69914899
65	Glutathione metabolism_Homo sapiens_hsa00480	0.67674704
66	Carbon metabolism_Homo sapiens_hsa01200	0.65746237
67	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.63545165
68	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60811584
69	Metabolic pathways_Homo sapiens_hsa01100	0.60620265
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59769263
71	Sulfur metabolism_Homo sapiens_hsa00920	0.59751692
72	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.56436746
73	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56045154
74	Long-term depression_Homo sapiens_hsa04730	0.55242044
75	Taste transduction_Homo sapiens_hsa04742	0.52517274
76	Dopaminergic synapse_Homo sapiens_hsa04728	0.49732015
77	Basal cell carcinoma_Homo sapiens_hsa05217	0.48480819
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.47905556
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.47804705
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.47406756
81	Insulin secretion_Homo sapiens_hsa04911	0.47370195
82	Wnt signaling pathway_Homo sapiens_hsa04310	0.46708652
83	GABAergic synapse_Homo sapiens_hsa04727	0.43171212
84	Amphetamine addiction_Homo sapiens_hsa05031	0.41692019
85	Ether lipid metabolism_Homo sapiens_hsa00565	0.41348549
86	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.41215968
87	Retinol metabolism_Homo sapiens_hsa00830	0.40913514
88	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.38715308
89	Circadian entrainment_Homo sapiens_hsa04713	0.37200634
90	Hippo signaling pathway_Homo sapiens_hsa04390	0.36355377
91	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35995087
92	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.34811013
93	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.34648327
94	Alcoholism_Homo sapiens_hsa05034	0.30842160
95	Vibrio cholerae infection_Homo sapiens_hsa05110	0.29641906
96	Alzheimers disease_Homo sapiens_hsa05010	0.29369490
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.28404830
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.27916031
99	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.27462661
100	Caffeine metabolism_Homo sapiens_hsa00232	0.26794780

ABCA11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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