ABCA12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* multicellular organismal water homeostasis (GO:0050891)8.25498258
2keratinocyte differentiation (GO:0030216)7.42870097
3molting cycle (GO:0042303)7.15739902
4hair cycle (GO:0042633)7.15739902
5* water homeostasis (GO:0030104)6.74189099
6detection of bacterium (GO:0016045)6.31046436
7keratinocyte proliferation (GO:0043616)6.30964544
8sphingoid metabolic process (GO:0046519)6.07425552
9bundle of His cell to Purkinje myocyte communication (GO:0086069)6.03426215
10hemidesmosome assembly (GO:0031581)5.96065476
11peptide cross-linking (GO:0018149)5.94936152
12long-chain fatty acid biosynthetic process (GO:0042759)5.92663436
13epidermal cell differentiation (GO:0009913)5.87732322
14detection of other organism (GO:0098543)5.71617590
15regulation of cell proliferation involved in kidney development (GO:1901722)5.49286493
16sphingosine metabolic process (GO:0006670)5.31154758
17gap junction assembly (GO:0016264)5.06167154
18positive regulation of interleukin-8 secretion (GO:2000484)5.01044546
19diol metabolic process (GO:0034311)5.00623129
20epidermis development (GO:0008544)4.98856964
21intermediate filament organization (GO:0045109)4.89620231
22G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.89184096
23intestinal epithelial cell development (GO:0060576)4.75233066
24lipoxygenase pathway (GO:0019372)4.73105821
25polarized epithelial cell differentiation (GO:0030859)4.62979917
26positive regulation of glomerulus development (GO:0090193)4.54569943
27epithelial cell differentiation involved in prostate gland development (GO:0060742)4.50003895
28negative regulation of keratinocyte proliferation (GO:0010839)4.46813134
29regulation of keratinocyte differentiation (GO:0045616)4.46003083
30regulation of transforming growth factor beta1 production (GO:0032908)4.41434757
31keratinocyte development (GO:0003334)4.36261793
32regulation of interleukin-8 secretion (GO:2000482)4.22891096
33glucosamine-containing compound catabolic process (GO:1901072)4.10945147
34regulation of ruffle assembly (GO:1900027)4.09842942
35cell-substrate junction assembly (GO:0007044)3.85965514
36fatty acid elongation (GO:0030497)3.84059513
37lateral sprouting from an epithelium (GO:0060601)3.80681440
38skin morphogenesis (GO:0043589)3.80390902
39linoleic acid metabolic process (GO:0043651)3.78705667
40regulation of glomerulus development (GO:0090192)3.73158492
41ectoderm development (GO:0007398)3.67002979
42detection of external biotic stimulus (GO:0098581)3.66353461
43ceramide biosynthetic process (GO:0046513)3.56967207
44regulation of phospholipase A2 activity (GO:0032429)3.46143400
45ventricular cardiac muscle cell action potential (GO:0086005)3.41502355
46regulation of epidermis development (GO:0045682)3.40516370
47polyketide metabolic process (GO:0030638)3.40325907
48doxorubicin metabolic process (GO:0044598)3.40325907
49daunorubicin metabolic process (GO:0044597)3.40325907
50phospholipid scrambling (GO:0017121)3.33610950
51dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.31113157
52eyelid development in camera-type eye (GO:0061029)3.16431862
53regulation of epidermal cell differentiation (GO:0045604)3.13341086
54phosphatidylinositol acyl-chain remodeling (GO:0036149)3.09157784
55epithelial cell maturation (GO:0002070)3.08739447
56detection of biotic stimulus (GO:0009595)3.05938107
57intermediate filament cytoskeleton organization (GO:0045104)3.01523290
58regulation of chemokine secretion (GO:0090196)2.99389028
59intermediate filament-based process (GO:0045103)2.99368881
60epithelial cell-cell adhesion (GO:0090136)2.98355964
61phosphatidylserine metabolic process (GO:0006658)2.95979219
62cyclooxygenase pathway (GO:0019371)2.93867127
63regulation of natural killer cell differentiation (GO:0032823)2.92019134
64superoxide anion generation (GO:0042554)2.91712787
65purinergic nucleotide receptor signaling pathway (GO:0035590)2.84965104
66regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.79704884
67hair follicle morphogenesis (GO:0031069)2.78451649
68regulation of hypersensitivity (GO:0002883)2.77173960
69phosphatidylserine acyl-chain remodeling (GO:0036150)2.77152644
70regulation of keratinocyte proliferation (GO:0010837)2.76875102
71establishment of tissue polarity (GO:0007164)2.75134455
72establishment of planar polarity (GO:0001736)2.75134455
73regulation of heart rate by cardiac conduction (GO:0086091)2.73846082
74negative regulation of cell fate specification (GO:0009996)2.73223329
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72965880
76atrioventricular valve morphogenesis (GO:0003181)2.67768444
77positive regulation of transforming growth factor beta production (GO:0071636)2.66990852
78positive regulation of epidermis development (GO:0045684)2.66604240
79positive regulation of T cell chemotaxis (GO:0010820)2.66323202
80regulation of T cell chemotaxis (GO:0010819)2.66323202
81regulation of hair cycle (GO:0042634)2.64826994
82phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.64826883
83cell communication involved in cardiac conduction (GO:0086065)2.64365080
84negative regulation of stress fiber assembly (GO:0051497)2.63719233
85negative regulation of interferon-gamma production (GO:0032689)2.63244508
86dendritic cell migration (GO:0036336)2.62765567
87positive regulation of hair follicle development (GO:0051798)2.61493253
88positive regulation of hair cycle (GO:0042635)2.61493253
89sequestering of metal ion (GO:0051238)2.61218005
90positive regulation of interleukin-1 secretion (GO:0050716)2.59414991
91epithelium development (GO:0060429)2.56757732
92phospholipid catabolic process (GO:0009395)2.56685672
93positive regulation of epidermal cell differentiation (GO:0045606)2.55485703
94cell-cell junction assembly (GO:0007043)2.54980536
95cellular component disassembly involved in execution phase of apoptosis (GO:0006921)2.54435523
96molting cycle process (GO:0022404)2.54388788
97hair cycle process (GO:0022405)2.54388788
98negative regulation of kidney development (GO:0090185)2.54007412
99G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.53759392
100planar cell polarity pathway involved in neural tube closure (GO:0090179)2.53357308
101cardiac right ventricle morphogenesis (GO:0003215)2.51046283
102negative regulation of interleukin-17 production (GO:0032700)2.50666662
103alditol phosphate metabolic process (GO:0052646)2.50315423
104negative regulation of cell fate commitment (GO:0010454)2.50158737
105regulation of somitogenesis (GO:0014807)2.49378095
106positive regulation of chemokine secretion (GO:0090197)2.48397432
107negative regulation of epidermis development (GO:0045683)2.47838908
108cytoskeletal anchoring at plasma membrane (GO:0007016)2.46431635
109branching involved in mammary gland duct morphogenesis (GO:0060444)2.45121304
110phosphatidylcholine acyl-chain remodeling (GO:0036151)2.43459254
111mitotic G1 DNA damage checkpoint (GO:0031571)2.42194710
112prostate gland epithelium morphogenesis (GO:0060740)2.42065305
113sphingolipid biosynthetic process (GO:0030148)2.41084329
114mammary gland epithelial cell proliferation (GO:0033598)2.40407518
115T-helper cell differentiation (GO:0042093)2.40211281
116CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.40211281
117positive regulation of keratinocyte differentiation (GO:0045618)2.38094085
118limb bud formation (GO:0060174)2.37883739
119skin development (GO:0043588)2.37204305
120phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.36759556
121L-fucose catabolic process (GO:0042355)2.36096336
122fucose catabolic process (GO:0019317)2.36096336
123L-fucose metabolic process (GO:0042354)2.36096336
124regulation of hair follicle development (GO:0051797)2.36042151
125epithelial cell proliferation (GO:0050673)2.35455424
126positive regulation of monocyte chemotaxis (GO:0090026)2.34570861
127regulation of cardioblast differentiation (GO:0051890)2.34000276
128positive regulation of interleukin-1 beta secretion (GO:0050718)2.33598516
129genitalia morphogenesis (GO:0035112)2.32197475
130cell junction organization (GO:0034330)2.31590006
131epithelial cell differentiation (GO:0030855)2.31455826
132prostaglandin biosynthetic process (GO:0001516)2.30883071
133prostanoid biosynthetic process (GO:0046457)2.30883071
134positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.30645645
135virion attachment to host cell (GO:0019062)2.28769169
136adhesion of symbiont to host cell (GO:0044650)2.28769169
137morphogenesis of embryonic epithelium (GO:0016331)2.28721624
138sympathetic nervous system development (GO:0048485)2.27047675
139embryonic camera-type eye development (GO:0031076)2.27040782
140cell junction assembly (GO:0034329)2.26970475
141oocyte development (GO:0048599)2.26947898
142positive regulation of interleukin-1 production (GO:0032732)2.26360106
143* establishment of skin barrier (GO:0061436)14.8518247
144* regulation of water loss via skin (GO:0033561)12.7837096
145* keratinization (GO:0031424)12.3019133
146desmosome organization (GO:0002934)11.9984358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.61724213
2ESR1_20079471_ChIP-ChIP_T-47D_Human4.18909430
3* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.57782002
4HIF1A_21447827_ChIP-Seq_MCF-7_Human2.54617683
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.38083251
6SOX9_24532713_ChIP-Seq_HFSC_Mouse2.28495396
7TP63_17297297_ChIP-ChIP_HaCaT_Human10.8943845
8* GATA3_24758297_ChIP-Seq_MCF-7_Human1.96600639
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92888642
10ESR1_21235772_ChIP-Seq_MCF-7_Human1.92834449
11RUNX1_27514584_Chip-Seq_MCF-7_Human1.87155711
12BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85671624
13ZNF263_19887448_ChIP-Seq_K562_Human1.84473998
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.80838833
15STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80458862
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.70600601
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69711702
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64468912
19RACK7_27058665_Chip-Seq_MCF-7_Human1.63628236
20VDR_22108803_ChIP-Seq_LS180_Human1.62920543
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58007222
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.57548929
23* TP53_18474530_ChIP-ChIP_U2OS_Human1.57133144
24ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.55836049
25FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.55377807
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.54618734
27SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54045193
28SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54045193
29GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.51779205
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51180152
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.48272752
32RXR_22108803_ChIP-Seq_LS180_Human1.47878351
33ATF3_27146783_Chip-Seq_COLON_Human1.46437257
34SOX2_20726797_ChIP-Seq_SW620_Human1.45032066
35* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44350355
36KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.44324331
37TP63_22573176_ChIP-Seq_HFKS_Human1.44251118
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.43848325
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.41636798
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.39194902
41* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36819271
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36569921
43UBF1/2_26484160_Chip-Seq_HMECs_Human1.36257810
44* TP63_23658742_ChIP-Seq_EP156T_Human1.35778540
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35231040
46GATA6_21074721_ChIP-Seq_CACO-2_Human1.34287690
47* TCF4_18268006_ChIP-ChIP_LS174T_Human1.34086362
48GATA6_25053715_ChIP-Seq_YYC3_Human1.33921454
49* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33740643
50PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28701348
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.28522040
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28120198
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.27809037
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.26916535
55* CJUN_26792858_Chip-Seq_BT549_Human1.26477474
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.26194439
57* NFE2_27457419_Chip-Seq_LIVER_Mouse1.25782996
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.23864257
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23739713
60* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22962703
61JARID2_20075857_ChIP-Seq_MESCs_Mouse1.21837253
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.21302301
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21002079
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.20579812
65BCAT_22108803_ChIP-Seq_LS180_Human1.18682785
66GBX2_23144817_ChIP-Seq_PC3_Human1.17753425
67FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15690396
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14608185
69* EZH2_27294783_Chip-Seq_NPCs_Mouse1.14333219
70EGR1_19032775_ChIP-ChIP_M12_Human1.12500315
71FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12052221
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11864462
73ELF5_23300383_ChIP-Seq_T47D_Human1.11774340
74AR_21572438_ChIP-Seq_LNCaP_Human1.10632172
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10331842
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.10250536
77CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09349135
78RBPJ_21746931_ChIP-Seq_IB4_Human1.09314053
79AHR_22903824_ChIP-Seq_MCF-7_Human1.08400604
80* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06902171
81SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.06650594
82AR_21909140_ChIP-Seq_LNCAP_Human1.06508885
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.06242263
84ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05770543
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05135195
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05135195
87HNFA_21074721_ChIP-Seq_CACO-2_Human1.04585928
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04507685
89* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03556115
90TCF4_22108803_ChIP-Seq_LS180_Human1.03475689
91ESR2_21235772_ChIP-Seq_MCF-7_Human1.02786688
92RNF2_27304074_Chip-Seq_NSC_Mouse1.02587523
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02448517
94* FLI1_27457419_Chip-Seq_LIVER_Mouse1.02311255
95* PIAS1_25552417_ChIP-Seq_VCAP_Human1.01187120
96AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00974156
97* KLF5_25053715_ChIP-Seq_YYC3_Human1.00638435
98* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99801597
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98973565
100* NANOG_18555785_Chip-Seq_ESCs_Mouse0.98382999
101EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97570022
102GATA1_22025678_ChIP-Seq_K562_Human0.97428297
103AR_25329375_ChIP-Seq_VCAP_Human0.96514734
104SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96318883
105* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95135858
106* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94971438
107* P53_22387025_ChIP-Seq_ESCs_Mouse0.94871306
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.94728440
109P300_19829295_ChIP-Seq_ESCs_Human0.94462376
110CLOCK_20551151_ChIP-Seq_293T_Human0.94285985
111HTT_18923047_ChIP-ChIP_STHdh_Human0.94133895
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93998056
113CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93484400
114* STAT3_18555785_Chip-Seq_ESCs_Mouse0.93471374
115PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93337655
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.92842348
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.91992918
118* NMYC_18555785_Chip-Seq_ESCs_Mouse0.91571103
119* PU1_27457419_Chip-Seq_LIVER_Mouse0.90637938
120PHF8_20622853_ChIP-Seq_HELA_Human0.90471985
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89943498
122* OCT4_18555785_Chip-Seq_ESCs_Mouse0.88895197
123* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88591924
124* SOX2_18555785_Chip-Seq_ESCs_Mouse0.87890501
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86642847
126* CTCF_18555785_Chip-Seq_ESCs_Mouse0.86017699
127CEBPB_22108803_ChIP-Seq_LS180_Human0.84562737
128* GATA4_25053715_ChIP-Seq_YYC3_Human0.84138029
129ETV1_20927104_ChIP-Seq_GIST48_Human0.83691472
130TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.83163942
131* TAL1_26923725_Chip-Seq_HPCs_Mouse0.82899686
132RARG_19884340_ChIP-ChIP_MEFs_Mouse0.82236691
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80765723
134FOXA1_25552417_ChIP-Seq_VCAP_Human0.77308336
135NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.75712041
136JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75190871
137TP53_16413492_ChIP-PET_HCT116_Human0.74629199
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74155435
139ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.74080889
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.73963400
141JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72799936
142P300_27058665_Chip-Seq_ZR-75-30cells_Human0.72024702
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.71914356
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.71914356
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.71886158
146FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.70485776
147CHD1_26751641_Chip-Seq_LNCaP_Human0.69549141
148HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68959790
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68290137
150CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68092631
151GATA2_21666600_ChIP-Seq_HMVEC_Human0.66694444
152FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.65674057
153CTCF_27219007_Chip-Seq_Bcells_Human0.63371372
154SMAD3_21741376_ChIP-Seq_HESCs_Human0.61961295
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61327975
156PPARA_22158963_ChIP-Seq_LIVER_Mouse0.58763744
157SMC4_20622854_ChIP-Seq_HELA_Human0.58081643
158ERG_21242973_ChIP-ChIP_JURKAT_Human0.57747122
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.57587486
160CDX2_22108803_ChIP-Seq_LS180_Human0.55299585
161ERG_20517297_ChIP-Seq_VCAP_Human0.51403600
162PKCTHETA_26484144_Chip-Seq_BREAST_Human0.51069881
163MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.50684615
164ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.50607512
165CREB1_26743006_Chip-Seq_LNCaP_Human0.50044717

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0002796_impaired_skin_barrier7.99102387
2MP0005275_abnormal_skin_tensile5.96823674
3* MP0005501_abnormal_skin_physiology4.87003736
4MP0005451_abnormal_body_composition4.77132662
5MP0010234_abnormal_vibrissa_follicle4.68484752
6MP0004381_abnormal_hair_follicle4.17677891
7MP0000579_abnormal_nail_morphology4.10561102
8* MP0001216_abnormal_epidermal_layer3.25262902
9MP0004947_skin_inflammation3.16666442
10* MP0002060_abnormal_skin_morphology3.09974253
11* MP0010771_integument_phenotype3.02204334
12MP0004264_abnormal_extraembryonic_tissu2.93454790
13MP0000383_abnormal_hair_follicle2.89782051
14MP0002254_reproductive_system_inflammat2.87622842
15MP0002098_abnormal_vibrissa_morphology2.80273625
16MP0010678_abnormal_skin_adnexa2.78516341
17MP0000647_abnormal_sebaceous_gland2.68007179
18MP0000566_synostosis2.53407524
19MP0003453_abnormal_keratinocyte_physiol2.45548665
20MP0000427_abnormal_hair_cycle2.24037323
21MP0000377_abnormal_hair_follicle2.08126208
22MP0000467_abnormal_esophagus_morphology2.06695207
23MP0001188_hyperpigmentation1.99285930
24* MP0003941_abnormal_skin_development1.96584638
25MP0000762_abnormal_tongue_morphology1.91826147
26MP0003136_yellow_coat_color1.81501017
27MP0009379_abnormal_foot_pigmentation1.77690312
28MP0003878_abnormal_ear_physiology1.69601999
29MP0005377_hearing/vestibular/ear_phenot1.69601999
30MP0004885_abnormal_endolymph1.69548030
31MP0001346_abnormal_lacrimal_gland1.61870816
32* MP0009931_abnormal_skin_appearance1.60348266
33MP0002009_preneoplasia1.52362192
34MP0009780_abnormal_chondrocyte_physiolo1.49096446
35* MP0001191_abnormal_skin_condition1.47624189
36MP0004185_abnormal_adipocyte_glucose1.31141008
37MP0000367_abnormal_coat/_hair1.30869121
38MP0000372_irregular_coat_pigmentation1.26476507
39MP0002095_abnormal_skin_pigmentation1.19464814
40MP0001243_abnormal_dermal_layer1.18081858
41MP0002277_abnormal_respiratory_mucosa1.17997070
42MP0003566_abnormal_cell_adhesion1.14824514
43MP0009053_abnormal_anal_canal1.13004700
44MP0008004_abnormal_stomach_pH1.09816458
45MP0003950_abnormal_plasma_membrane1.05086211
46MP0005409_darkened_coat_color1.04786615
47MP0000465_gastrointestinal_hemorrhage0.96476116
48MP0005257_abnormal_intraocular_pressure0.96101678
49MP0002177_abnormal_outer_ear0.94419228
50MP0003315_abnormal_perineum_morphology0.94374219
51MP0003705_abnormal_hypodermis_morpholog0.89922639
52MP0005171_absent_coat_pigmentation0.87967824
53MP0005023_abnormal_wound_healing0.87711339
54MP0002822_catalepsy0.82965947
55MP0005075_abnormal_melanosome_morpholog0.82159554
56MP0001851_eye_inflammation0.81391019
57MP0002234_abnormal_pharynx_morphology0.79678993
58MP0004272_abnormal_basement_membrane0.77726150
59MP0001340_abnormal_eyelid_morphology0.73976400
60MP0010386_abnormal_urinary_bladder0.71118617
61MP0000538_abnormal_urinary_bladder0.70078030
62MP0003011_delayed_dark_adaptation0.69520270
63MP0001873_stomach_inflammation0.68283492
64MP0009384_cardiac_valve_regurgitation0.68259031
65MP0002249_abnormal_larynx_morphology0.68176623
66MP0005076_abnormal_cell_differentiation0.67684713
67MP0003183_abnormal_peptide_metabolism0.67191967
68MP0002132_abnormal_respiratory_system0.67141171
69MP0005408_hypopigmentation0.66712289
70MP0002148_abnormal_hypersensitivity_rea0.64901550
71MP0010030_abnormal_orbit_morphology0.64786346
72MP0002006_tumorigenesis0.62810454
73MP0000678_abnormal_parathyroid_gland0.62407919
74MP0005174_abnormal_tail_pigmentation0.62113905
75MP0000470_abnormal_stomach_morphology0.61717662
76MP0003638_abnormal_response/metabolism_0.60666918
77MP0001881_abnormal_mammary_gland0.55806995
78MP0001984_abnormal_olfaction0.54661035
79MP0001849_ear_inflammation0.54343798
80MP0000015_abnormal_ear_pigmentation0.53147150
81MP0003755_abnormal_palate_morphology0.53078705
82MP0000537_abnormal_urethra_morphology0.50668805
83* MP0001784_abnormal_fluid_regulation0.48981996
84MP0004019_abnormal_vitamin_homeostasis0.48849705
85MP0003385_abnormal_body_wall0.47466488
86MP0002282_abnormal_trachea_morphology0.47286867
87MP0004233_abnormal_muscle_weight0.45747661
88MP0010155_abnormal_intestine_physiology0.45335448
89MP0003763_abnormal_thymus_physiology0.44722974
90MP0005645_abnormal_hypothalamus_physiol0.44401001
91MP0002166_altered_tumor_susceptibility0.43834503
92MP0000627_abnormal_mammary_gland0.43348938
93MP0006292_abnormal_olfactory_placode0.42899198
94MP0003936_abnormal_reproductive_system0.42703302
95MP0000516_abnormal_urinary_system0.41906784
96MP0005367_renal/urinary_system_phenotyp0.41906784
97MP0004742_abnormal_vestibular_system0.41875099
98MP0009250_abnormal_appendicular_skeleto0.41183478
99MP0003045_fibrosis0.40387489
100MP0002111_abnormal_tail_morphology0.40259659
101MP0002896_abnormal_bone_mineralization0.38789455
102* MP0004782_abnormal_surfactant_physiolog0.38364287
103MP0005508_abnormal_skeleton_morphology0.38086369
104MP0010352_gastrointestinal_tract_polyps0.37547331
105MP0009785_altered_susceptibility_to0.37103362
106MP0001186_pigmentation_phenotype0.36482886
107MP0002233_abnormal_nose_morphology0.35949428
108MP0002697_abnormal_eye_size0.35638981
109MP0002877_abnormal_melanocyte_morpholog0.35189876
110MP0008961_abnormal_basal_metabolism0.33673198
111MP0002109_abnormal_limb_morphology0.32832741
112MP0001919_abnormal_reproductive_system0.31919867
113MP0009764_decreased_sensitivity_to0.31494240
114MP0000462_abnormal_digestive_system0.31334216
115MP0001542_abnormal_bone_strength0.29635967
116MP0000858_altered_metastatic_potential0.29418633
117MP0003938_abnormal_ear_development0.29112306
118MP0000613_abnormal_salivary_gland0.28224350
119MP0005248_abnormal_Harderian_gland0.28181603
120MP0005083_abnormal_biliary_tract0.28108396
121MP0005647_abnormal_sex_gland0.27839902
122* MP0000432_abnormal_head_morphology0.27792101
123MP0005025_abnormal_response_to0.26737766
124* MP0004197_abnormal_fetal_growth/weight/0.25353771
125MP0001765_abnormal_ion_homeostasis0.24502381
126MP0005666_abnormal_adipose_tissue0.23882339
127MP0005375_adipose_tissue_phenotype0.23285870
128MP0006138_congestive_heart_failure0.23031778
129MP0000371_diluted_coat_color0.22572079
130MP0008789_abnormal_olfactory_epithelium0.22366754
131MP0002089_abnormal_postnatal_growth/wei0.20003016
132MP0005503_abnormal_tendon_morphology0.18809188
133MP0005193_abnormal_anterior_eye0.18103686
134MP0002168_other_aberrant_phenotype0.17213259
135MP0005621_abnormal_cell_physiology0.16807995

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)7.50483039
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.76127637
3Hypotrichosis (HP:0001006)6.39527909
4Plantar hyperkeratosis (HP:0007556)6.30240819
5Palmoplantar hyperkeratosis (HP:0000972)6.19374466
6* Congenital ichthyosiform erythroderma (HP:0007431)6.08308277
7Onycholysis (HP:0001806)6.08274904
8Palmar hyperkeratosis (HP:0010765)5.88814299
9Parakeratosis (HP:0001036)5.84542155
10Erythroderma (HP:0001019)5.83525113
11Right ventricular cardiomyopathy (HP:0011663)5.35506162
12Woolly hair (HP:0002224)5.31993987
13Erythema (HP:0010783)5.22714210
14Lip pit (HP:0100267)4.91509650
15* Abnormality of nail color (HP:0100643)4.67778309
16Alopecia of scalp (HP:0002293)4.63247379
17Thick nail (HP:0001805)4.40593462
18Fragile nails (HP:0001808)4.39703283
19Eczematoid dermatitis (HP:0000976)4.26364284
20Pili torti (HP:0003777)3.83655852
21Milia (HP:0001056)3.78427798
22* Gangrene (HP:0100758)3.77974888
23* Ectropion (HP:0000656)3.67139727
24Abnormal blistering of the skin (HP:0008066)3.65647746
25Sparse eyelashes (HP:0000653)3.61807871
26Follicular hyperkeratosis (HP:0007502)3.59102738
27* Corneal erosion (HP:0200020)3.44391894
28Conjunctival hamartoma (HP:0100780)3.43269828
29Nail dystrophy (HP:0008404)3.42812524
30Distal lower limb muscle weakness (HP:0009053)3.36857537
31* Pruritus (HP:0000989)3.34395349
32* Hypohidrosis (HP:0000966)3.30493704
33Curly hair (HP:0002212)3.27392173
34* Palmoplantar keratoderma (HP:0000982)3.25126848
35Natal tooth (HP:0000695)3.24534695
36Ventricular tachycardia (HP:0004756)3.13243465
37Aplasia cutis congenita (HP:0001057)2.93114135
38Advanced eruption of teeth (HP:0006288)2.92099705
39Abnormality of secondary sexual hair (HP:0009888)2.88448514
40Abnormality of the axillary hair (HP:0100134)2.88448514
41Sparse scalp hair (HP:0002209)2.84927933
42Hypoplastic labia majora (HP:0000059)2.74799688
43Septate vagina (HP:0001153)2.70640444
44Atrophic scars (HP:0001075)2.64659100
45Selective tooth agenesis (HP:0001592)2.63775904
46Hypergammaglobulinemia (HP:0010702)2.50901761
47Abnormality of the labia majora (HP:0012881)2.48306062
48Hyporeflexia of lower limbs (HP:0002600)2.42106732
49Autoamputation (HP:0001218)2.41593755
50Corneal dystrophy (HP:0001131)2.38580850
51Amniotic constriction ring (HP:0009775)2.36930497
52Abnormality of placental membranes (HP:0011409)2.36930497
53Furrowed tongue (HP:0000221)2.35510362
54Prostate neoplasm (HP:0100787)2.33286212
55Ridged nail (HP:0001807)2.32676227
56Popliteal pterygium (HP:0009756)2.30875621
57Congenital, generalized hypertrichosis (HP:0004540)2.28369320
58Fatigable weakness (HP:0003473)2.28184278
59Abnormality of the neuromuscular junction (HP:0003398)2.28184278
60Abnormality of hair growth rate (HP:0011363)2.26281279
61Slow-growing hair (HP:0002217)2.26281279
62Abnormal hair laboratory examination (HP:0003328)2.24740475
63Pustule (HP:0200039)2.22892499
64Conical tooth (HP:0000698)2.22764550
65Blepharitis (HP:0000498)2.22537447
66Acanthosis nigricans (HP:0000956)2.17007806
67Absent eyebrow (HP:0002223)2.15004067
68Anonychia (HP:0001798)2.05639263
69Carious teeth (HP:0000670)2.05331926
70Anhidrosis (HP:0000970)2.04493681
71* Dry skin (HP:0000958)2.04174916
72Patchy hypopigmentation of hair (HP:0011365)1.98882493
73Severe Myopia (HP:0011003)1.98450630
74* Dehydration (HP:0001944)1.97435653
75Cheilitis (HP:0100825)1.96430835
76Unilateral renal agenesis (HP:0000122)1.93562620
77Abnormality of permanent molar morphology (HP:0011071)1.93417005
78Abnormality of the dental root (HP:0006486)1.93417005
79Taurodontia (HP:0000679)1.93417005
80Areflexia of lower limbs (HP:0002522)1.92193980
81Depressed nasal tip (HP:0000437)1.91596294
82Duplicated collecting system (HP:0000081)1.90850043
83Brittle hair (HP:0002299)1.90532297
84Concave nail (HP:0001598)1.90028577
85Premature loss of primary teeth (HP:0006323)1.87870193
86White forelock (HP:0002211)1.87674234
87Dry hair (HP:0011359)1.85631214
88Skin ulcer (HP:0200042)1.84612394
89Melanocytic nevus (HP:0000995)1.78819626
90Pterygium (HP:0001059)1.78553691
91Hyperhidrosis (HP:0000975)1.75275294
92Alveolar cell carcinoma (HP:0006519)1.72744322
93Abnormality of the dental pulp (HP:0006479)1.72202727
94Hamartoma of the eye (HP:0010568)1.71328299
95Fragile skin (HP:0001030)1.70531301
96Hypoplasia of dental enamel (HP:0006297)1.70064317
97Nasolacrimal duct obstruction (HP:0000579)1.70053462
98Amelogenesis imperfecta (HP:0000705)1.69808718
99Fine hair (HP:0002213)1.67155896
100Multifactorial inheritance (HP:0001426)1.66818003
101Urticaria (HP:0001025)1.66300659
102Septo-optic dysplasia (HP:0100842)1.61995890
103Abnormality of the salivary glands (HP:0010286)1.61658156
104Abnormality of incisor morphology (HP:0011063)1.61338510
105Abnormality of the renal collecting system (HP:0004742)1.60582265
106Laryngomalacia (HP:0001601)1.58004855
107Asthma (HP:0002099)1.57824254
108Oral leukoplakia (HP:0002745)1.55400967
109Upper limb muscle weakness (HP:0003484)1.55133859
110Abnormality of the fingernails (HP:0001231)1.55100170
111Congenital sensorineural hearing impairment (HP:0008527)1.53569389
112Split foot (HP:0001839)1.53482595
113Oligodontia (HP:0000677)1.52318863
114Abnormality of the gastric mucosa (HP:0004295)1.50405181
115Xerostomia (HP:0000217)1.50334526
116Aplasia involving bones of the extremities (HP:0009825)1.49139234
117Aplasia involving bones of the upper limbs (HP:0009823)1.49139234
118Aplasia of the phalanges of the hand (HP:0009802)1.49139234
119Labial hypoplasia (HP:0000066)1.47974612
120Recurrent corneal erosions (HP:0000495)1.47373664
121Absent hair (HP:0002298)1.47046844
122Absent eyelashes (HP:0000561)1.46794620
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.46468524
124* Lack of skin elasticity (HP:0100679)1.45355363
125Abnormality of molar (HP:0011077)1.44648610
126Abnormality of molar morphology (HP:0011070)1.44648610
127Hypodontia (HP:0000668)1.44407786
128Orchitis (HP:0100796)1.43778780
129Increased connective tissue (HP:0009025)1.43248672

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R6.91697498
2TGFBR13.58137643
3CASK3.25819818
4CDK123.19354215
5MST42.80328383
6MAPKAPK32.62675300
7SIK12.56782886
8TRIB32.55948428
9MAP3K92.53594688
10LATS12.52048056
11RIPK12.46601358
12PIK3CA2.37506465
13MAP3K142.10967092
14FER2.08633120
15STK242.03321159
16ZAK1.93440525
17STK38L1.93352286
18MAP3K21.91237302
19SCYL21.88250564
20MAP3K31.86056384
21PKN21.82756965
22EEF2K1.81492675
23MAP3K121.79784226
24EPHB21.71387797
25ERN11.70571941
26TRPM71.67903052
27MET1.67435985
28PIK3CG1.62785760
29PTK21.62300059
30CDK31.58538209
31GRK71.58124829
32IRAK31.57773560
33BMPR1B1.56610788
34ERBB31.54972069
35BMPR21.51058881
36EIF2AK21.50444519
37SIK31.46200777
38IKBKE1.45320432
39FGFR11.43325380
40EPHA31.40361638
41TXK1.30587773
42MAP2K61.25037103
43EPHA21.22552297
44OBSCN1.21220227
45PRPF4B1.19144715
46SRPK11.16961444
47PDGFRA1.14629382
48SMG11.12215069
49PIM21.11099701
50GRK11.09375330
51TAOK21.07065963
52YES11.06851592
53RPS6KB21.04449185
54TGFBR21.01871371
55MAPKAPK51.01261180
56IRAK40.99633338
57MTOR0.98782401
58MUSK0.96449417
59PRKCI0.95492183
60ADRBK20.95406838
61GRK60.94289939
62NTRK10.94224223
63RPS6KB10.93260330
64BCR0.91124699
65TBK10.90154802
66NTRK20.89813276
67IKBKB0.86477710
68TESK10.86441963
69BLK0.86164368
70PDGFRB0.85793130
71RET0.83556059
72TNIK0.83525750
73INSRR0.83117500
74BRD40.82134138
75IRAK10.80266895
76TNK20.78296336
77FGFR30.77145587
78PBK0.73518067
79MAP3K10.72320984
80CDK70.71468313
81FLT30.70721306
82ADRBK10.70267578
83EPHB10.70266258
84PRKCE0.68103314
85NUAK10.67981743
86EIF2AK10.65046761
87STK380.64178176
88ITK0.63468884
89TAF10.60463206
90ERBB20.59842242
91MAP3K110.59521922
92SGK20.58824736
93TEC0.58690822
94STK100.56960997
95ICK0.56853752
96FRK0.56851601
97LATS20.55658482
98SGK2230.55448496
99SGK4940.55448496
100FGFR20.54726951
101ARAF0.51720444
102GRK50.51521910
103EIF2AK30.50325726
104MAPKAPK20.48147163
105MAP2K20.47955419
106IRAK20.47916262
107RPS6KA20.47912274
108MAP2K10.47822013
109PAK40.45640642
110PKN10.45550590
111MAP3K50.45428530
112WNK10.45168308
113ERBB40.43660009
114FGFR40.42152758
115STK30.41933167
116NEK60.41064788
117MAPK70.40720601
118PTK60.40611046
119MAP3K60.40143310
120KSR20.39722369
121TYK20.38289330
122MATK0.36871562
123SGK30.36753311
124MARK30.36174964
125TIE10.35270110
126TAOK10.33814227
127CSNK1D0.33034593
128CDK60.31481383
129CHUK0.30988617
130PRKD20.29244025
131CDK80.28081087
132PRKCA0.27919958
133ROCK10.27073549
134ILK0.26334878
135PLK40.26282414
136CAMK1G0.26031145
137LYN0.24708346
138ABL10.24033644
139SYK0.24001074
140LRRK20.23464122
141MELK0.23089610
142RPS6KL10.22642391
143RPS6KC10.22642391
144MAP3K70.21948584
145EPHA40.21437493
146PAK20.20962771
147AKT30.20911592
148AURKB0.20650425
149MAPK80.20573776
150MAPK110.19719598

Predicted pathways (KEGG)

RankGene SetZ-score
1Sphingolipid metabolism_Homo sapiens_hsa006003.95973336
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.19494923
3Linoleic acid metabolism_Homo sapiens_hsa005913.17155339
4Arachidonic acid metabolism_Homo sapiens_hsa005903.16671561
5Fatty acid elongation_Homo sapiens_hsa000622.20916924
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.17612891
7Mineral absorption_Homo sapiens_hsa049782.11966583
8Ether lipid metabolism_Homo sapiens_hsa005652.10870302
9VEGF signaling pathway_Homo sapiens_hsa043701.98377254
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.94493478
11Thyroid cancer_Homo sapiens_hsa052161.82474753
12Phototransduction_Homo sapiens_hsa047441.73617076
13Amoebiasis_Homo sapiens_hsa051461.68008895
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63341808
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.60095468
16Histidine metabolism_Homo sapiens_hsa003401.51885556
17Choline metabolism in cancer_Homo sapiens_hsa052311.47889297
18Small cell lung cancer_Homo sapiens_hsa052221.42785419
19Bladder cancer_Homo sapiens_hsa052191.42335437
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41760114
21Glioma_Homo sapiens_hsa052141.39120577
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.39022441
23Retinol metabolism_Homo sapiens_hsa008301.36731244
24Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35658622
25Estrogen signaling pathway_Homo sapiens_hsa049151.35151734
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34005359
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33645135
28Basal cell carcinoma_Homo sapiens_hsa052171.33407200
29Graft-versus-host disease_Homo sapiens_hsa053321.30079044
30MicroRNAs in cancer_Homo sapiens_hsa052061.26890631
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.25603891
32Adherens junction_Homo sapiens_hsa045201.22661088
33Sulfur metabolism_Homo sapiens_hsa009201.22491028
34Inositol phosphate metabolism_Homo sapiens_hsa005621.21442112
35Endometrial cancer_Homo sapiens_hsa052131.20751466
36Acute myeloid leukemia_Homo sapiens_hsa052211.20490036
37Serotonergic synapse_Homo sapiens_hsa047261.20185989
38Malaria_Homo sapiens_hsa051441.16861621
39Steroid biosynthesis_Homo sapiens_hsa001001.14975934
40Axon guidance_Homo sapiens_hsa043601.14920820
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14032076
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12210042
43NF-kappa B signaling pathway_Homo sapiens_hsa040641.11755142
44Tight junction_Homo sapiens_hsa045301.11011990
45Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10455029
46Renal cell carcinoma_Homo sapiens_hsa052111.08597251
47Proteoglycans in cancer_Homo sapiens_hsa052051.08288991
48Pertussis_Homo sapiens_hsa051331.06829229
49Hematopoietic cell lineage_Homo sapiens_hsa046401.06075882
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.04982153
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03864986
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00978036
53Central carbon metabolism in cancer_Homo sapiens_hsa052300.99305541
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.99099127
55Focal adhesion_Homo sapiens_hsa045100.97765451
56Hepatitis C_Homo sapiens_hsa051600.97623624
57Ovarian steroidogenesis_Homo sapiens_hsa049130.97451505
58ECM-receptor interaction_Homo sapiens_hsa045120.96465180
59Phenylalanine metabolism_Homo sapiens_hsa003600.95449167
60African trypanosomiasis_Homo sapiens_hsa051430.92822421
61Rheumatoid arthritis_Homo sapiens_hsa053230.91172467
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.90634826
63Steroid hormone biosynthesis_Homo sapiens_hsa001400.88949882
64Insulin signaling pathway_Homo sapiens_hsa049100.88703963
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86309981
66Pancreatic cancer_Homo sapiens_hsa052120.84345871
67Notch signaling pathway_Homo sapiens_hsa043300.83956125
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83561049
69Staphylococcus aureus infection_Homo sapiens_hsa051500.81870138
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81656206
71Prostate cancer_Homo sapiens_hsa052150.81654548
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.80806275
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80081243
74p53 signaling pathway_Homo sapiens_hsa041150.79667338
75Leishmaniasis_Homo sapiens_hsa051400.79395307
76Allograft rejection_Homo sapiens_hsa053300.78369240
77TNF signaling pathway_Homo sapiens_hsa046680.77186375
78Autoimmune thyroid disease_Homo sapiens_hsa053200.76309667
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75547938
80Hedgehog signaling pathway_Homo sapiens_hsa043400.75477353
81Ribosome_Homo sapiens_hsa030100.74527229
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73853818
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.72084817
84Ras signaling pathway_Homo sapiens_hsa040140.71381329
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.71340858
86Tuberculosis_Homo sapiens_hsa051520.71299633
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.70610065
88Other glycan degradation_Homo sapiens_hsa005110.69347701
89Primary immunodeficiency_Homo sapiens_hsa053400.68969279
90Endocytosis_Homo sapiens_hsa041440.68928778
91Influenza A_Homo sapiens_hsa051640.68614100
92Chronic myeloid leukemia_Homo sapiens_hsa052200.68545105
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68543635
94Melanogenesis_Homo sapiens_hsa049160.68542310
95Measles_Homo sapiens_hsa051620.68318110
96Toxoplasmosis_Homo sapiens_hsa051450.68223570
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68176467
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.67703064
99Tyrosine metabolism_Homo sapiens_hsa003500.67030439
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66476046
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.66320873
102Chemical carcinogenesis_Homo sapiens_hsa052040.66206019
103Hippo signaling pathway_Homo sapiens_hsa043900.65149718
104Non-small cell lung cancer_Homo sapiens_hsa052230.65146423
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64960560
106Calcium signaling pathway_Homo sapiens_hsa040200.64051180
107Salmonella infection_Homo sapiens_hsa051320.63869313
108Herpes simplex infection_Homo sapiens_hsa051680.63544682
109Legionellosis_Homo sapiens_hsa051340.62703678
110Platelet activation_Homo sapiens_hsa046110.62484296
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62323047
112Circadian rhythm_Homo sapiens_hsa047100.62218208
113AMPK signaling pathway_Homo sapiens_hsa041520.62094912
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61224898
115Prolactin signaling pathway_Homo sapiens_hsa049170.60989204
116Salivary secretion_Homo sapiens_hsa049700.60415441
117Pathways in cancer_Homo sapiens_hsa052000.60002201
118ErbB signaling pathway_Homo sapiens_hsa040120.57942231
119GnRH signaling pathway_Homo sapiens_hsa049120.57870740
120Melanoma_Homo sapiens_hsa052180.57697322
121Olfactory transduction_Homo sapiens_hsa047400.57327709
122Renin secretion_Homo sapiens_hsa049240.57106428
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56337774
124Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56063589
125Pancreatic secretion_Homo sapiens_hsa049720.55980875
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55932148
127Taste transduction_Homo sapiens_hsa047420.54698378
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54363874
129Protein digestion and absorption_Homo sapiens_hsa049740.53884491
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53497017
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52855382
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51753382
133Insulin resistance_Homo sapiens_hsa049310.51448680
134Gastric acid secretion_Homo sapiens_hsa049710.51305523
135Wnt signaling pathway_Homo sapiens_hsa043100.51112594
136Glucagon signaling pathway_Homo sapiens_hsa049220.50551060
137Dorso-ventral axis formation_Homo sapiens_hsa043200.49979628
138Asthma_Homo sapiens_hsa053100.49733530
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49118158
140Phagosome_Homo sapiens_hsa041450.49009764
141Long-term depression_Homo sapiens_hsa047300.48296945
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.48002751
143mTOR signaling pathway_Homo sapiens_hsa041500.47740601
144Collecting duct acid secretion_Homo sapiens_hsa049660.46815401
145Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46301633
146Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45126182
147* ABC transporters_Homo sapiens_hsa020100.44636130
148PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44003306
149HIF-1 signaling pathway_Homo sapiens_hsa040660.40921552
150Lysosome_Homo sapiens_hsa041420.39277116
151TGF-beta signaling pathway_Homo sapiens_hsa043500.37671350
152FoxO signaling pathway_Homo sapiens_hsa040680.35042590
153Oxytocin signaling pathway_Homo sapiens_hsa049210.34265646
154Rap1 signaling pathway_Homo sapiens_hsa040150.32639330
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32412356
156PPAR signaling pathway_Homo sapiens_hsa033200.31757567

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »