ABCA13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: In human, the ATP-binding cassette (ABC) family of transmembrane transporters has at least 48 genes and 7 gene subfamilies. This gene is a member of ABC gene subfamily A (ABCA). Genes within the ABCA family typically encode several thousand amino acids. Like other ABC transmembrane transporter proteins, this protein has 12 or more transmembrane alpha-helix domains that likely arrange to form a single central chamber with multiple substrate binding sites. It is also predicted to have two large extracellular domains and two nucleotide binding domains as is typical for ABCA proteins. Alternative splice variants have been described but their biological validity has not been demonstrated. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1left/right axis specification (GO:0070986)8.02817301
2regulation of cilium movement (GO:0003352)7.97564498
3left/right pattern formation (GO:0060972)7.83982405
4urate metabolic process (GO:0046415)7.17719901
5drug transmembrane transport (GO:0006855)7.16135406
6ventricular system development (GO:0021591)6.93877543
7neutrophil mediated immunity (GO:0002446)6.43606411
8intraciliary transport (GO:0042073)6.25462132
9cellular glucuronidation (GO:0052695)6.09087830
10cilium organization (GO:0044782)6.05061930
11organic cation transport (GO:0015695)5.97398401
12renal absorption (GO:0070293)5.94315098
13phosphate ion transport (GO:0006817)5.94163083
14excretion (GO:0007588)5.94101419
15microtubule bundle formation (GO:0001578)5.94049667
16glucuronate metabolic process (GO:0019585)5.92952991
17uronic acid metabolic process (GO:0006063)5.92952991
18drug transport (GO:0015893)5.91511102
19aminoglycoside antibiotic metabolic process (GO:0030647)5.87905179
20cilium assembly (GO:0042384)5.79572558
21response to peptidoglycan (GO:0032494)5.57406237
22phosphate ion transmembrane transport (GO:0035435)5.38551959
23vitamin transmembrane transport (GO:0035461)5.34961800
24diterpenoid biosynthetic process (GO:0016102)5.24558393
25primary alcohol catabolic process (GO:0034310)5.24028908
26leukocyte aggregation (GO:0070486)5.21075782
27disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.18752014
28killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.18752014
29response to xenobiotic stimulus (GO:0009410)5.14288941
30leukocyte migration involved in inflammatory response (GO:0002523)5.12222475
31protein localization to cilium (GO:0061512)4.92218423
32myeloid leukocyte mediated immunity (GO:0002444)4.89365830
33lateral ventricle development (GO:0021670)4.87063573
34ethanol metabolic process (GO:0006067)4.79718505
35defense response to fungus (GO:0050832)4.75010941
36microtubule-based movement (GO:0007018)4.71295121
37cellular component assembly involved in morphogenesis (GO:0010927)4.66968679
38phosphate ion homeostasis (GO:0055062)4.66643043
39trivalent inorganic anion homeostasis (GO:0072506)4.66643043
40polyol transport (GO:0015791)4.65469454
41regulation of microtubule-based movement (GO:0060632)4.57225953
42response to mercury ion (GO:0046689)4.48723575
43cilium morphogenesis (GO:0060271)4.45973803
44vitamin D metabolic process (GO:0042359)4.38074206
45bone remodeling (GO:0046849)4.37018901
46lysine catabolic process (GO:0006554)4.35916988
47lysine metabolic process (GO:0006553)4.35916988
48toxin transport (GO:1901998)4.35753023
49response to nitrosative stress (GO:0051409)4.34052282
50pyrimidine-containing compound transmembrane transport (GO:0072531)4.33707412
51quaternary ammonium group transport (GO:0015697)4.33422350
52regulation of interleukin-5 production (GO:0032674)4.33312198
53superoxide anion generation (GO:0042554)4.33059732
54centriole assembly (GO:0098534)4.24469685
55peptide catabolic process (GO:0043171)4.15066250
56nonribosomal peptide biosynthetic process (GO:0019184)4.13780812
57negative regulation of humoral immune response (GO:0002921)4.12867044
58cell projection assembly (GO:0030031)4.12814171
59drug catabolic process (GO:0042737)4.11724484
60negative regulation of immunoglobulin mediated immune response (GO:0002890)4.11262014
61negative regulation of B cell mediated immunity (GO:0002713)4.11262014
62tolerance induction (GO:0002507)4.09511693
63sequestering of metal ion (GO:0051238)3.99725281
64NADPH regeneration (GO:0006740)3.98528645
65response to fungus (GO:0009620)3.94607281
66killing of cells of other organism (GO:0031640)3.89160029
67disruption of cells of other organism (GO:0044364)3.89160029
68exogenous drug catabolic process (GO:0042738)3.85990554
69pentose-phosphate shunt (GO:0006098)3.84599506
70regulation of germinal center formation (GO:0002634)3.78108394
71negative regulation of T cell differentiation in thymus (GO:0033085)3.76885733
72metanephric nephron epithelium development (GO:0072243)3.74288743
73nephron tubule development (GO:0072080)3.72497876
74cysteine metabolic process (GO:0006534)3.71547369
75innate immune response in mucosa (GO:0002227)3.70796173
76positive regulation of T-helper cell differentiation (GO:0045624)3.68730510
77DNA damage response, detection of DNA damage (GO:0042769)3.66759935
78retinoic acid metabolic process (GO:0042573)3.66075926
79glutathione biosynthetic process (GO:0006750)3.63010942
80positive regulation of tolerance induction (GO:0002645)3.62381196
81modified amino acid transport (GO:0072337)3.61576011
82retinal rod cell development (GO:0046548)3.59982766
83terpenoid biosynthetic process (GO:0016114)3.58348305
84regulation of interleukin-13 production (GO:0032656)3.56924122
85ethanol oxidation (GO:0006069)3.53560897
86regulation of dendritic cell antigen processing and presentation (GO:0002604)3.53265873
87interleukin-6-mediated signaling pathway (GO:0070102)3.48207074
88glyoxylate metabolic process (GO:0046487)3.47622386
89renal tubule development (GO:0061326)3.47526076
90tricarboxylic acid metabolic process (GO:0072350)3.47194268
91metanephric tubule development (GO:0072170)3.46664104
92metanephric nephron tubule development (GO:0072234)3.46664104
93NADP metabolic process (GO:0006739)3.46199032
94metanephric epithelium development (GO:0072207)3.43142068
95leukotriene biosynthetic process (GO:0019370)3.42287717
96chronic inflammatory response (GO:0002544)3.41557633
97glomerular epithelial cell development (GO:0072310)3.40255176
98leukotriene metabolic process (GO:0006691)3.37057982
99one-carbon compound transport (GO:0019755)3.37001249
100retinal cone cell development (GO:0046549)3.36984912
101positive regulation of digestive system process (GO:0060456)3.35465595
102cytoplasmic microtubule organization (GO:0031122)3.34021107
103lung epithelium development (GO:0060428)3.33536060
104nucleotide transmembrane transport (GO:1901679)3.31327240
105determination of left/right symmetry (GO:0007368)3.28998994
106nephron epithelium development (GO:0072009)3.26934516
107leukocyte cell-cell adhesion (GO:0007159)3.26818688
108actin filament depolymerization (GO:0030042)3.25981012
109nucleoside diphosphate phosphorylation (GO:0006165)3.25244370
110carnitine transport (GO:0015879)3.24764691
111amino-acid betaine transport (GO:0015838)3.24764691
112pentose metabolic process (GO:0019321)3.21648468
113leukocyte tethering or rolling (GO:0050901)3.20481669
114phospholipid scrambling (GO:0017121)3.20371961
115valine metabolic process (GO:0006573)3.19966353
116positive regulation of Cdc42 GTPase activity (GO:0043089)3.19447667
117respiratory burst (GO:0045730)3.18438449
118cellular extravasation (GO:0045123)3.18035011
119determination of bilateral symmetry (GO:0009855)3.17599255
120sodium-independent organic anion transport (GO:0043252)3.15646369
121mucosal immune response (GO:0002385)3.13501842
122sperm capacitation (GO:0048240)3.10516656
123xenobiotic catabolic process (GO:0042178)3.10260237
124carnitine metabolic process (GO:0009437)3.09344599
125specification of symmetry (GO:0009799)3.08577456
126negative regulation of chemokine production (GO:0032682)3.08425833
127regulation of T-helper 2 cell differentiation (GO:0045628)3.07381053
128collecting duct development (GO:0072044)3.07252595
129O-glycan processing (GO:0016266)3.04764440
130photoreceptor cell maintenance (GO:0045494)3.04535790
131negative regulation of JUN kinase activity (GO:0043508)3.04269783
132hydrogen peroxide biosynthetic process (GO:0050665)3.04007854
133cilium or flagellum-dependent cell motility (GO:0001539)20.3613724
134microtubule polymerization or depolymerization (GO:0031109)2.99494190
135CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.98032821
136reactive oxygen species biosynthetic process (GO:1903409)2.97827329
137amino-acid betaine metabolic process (GO:0006577)2.96674097
138organ or tissue specific immune response (GO:0002251)2.96520120
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94355044
140microtubule depolymerization (GO:0007019)2.94050633
141detection of bacterium (GO:0016045)2.93696356
142establishment of apical/basal cell polarity (GO:0035089)2.93090534
143positive regulation of smoothened signaling pathway (GO:0045880)2.93008413
144establishment of planar polarity (GO:0001736)2.92349020
145establishment of tissue polarity (GO:0007164)2.92349020
146glutathione metabolic process (GO:0006749)2.91686366
147negative regulation of inclusion body assembly (GO:0090084)2.90439688
148surfactant homeostasis (GO:0043129)2.90106700
149neutrophil migration (GO:1990266)2.89797129
150phagosome maturation (GO:0090382)2.87827615
151calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.85415592
152regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.85363578
153peptide biosynthetic process (GO:0043043)2.83095936
154antibacterial humoral response (GO:0019731)2.82967679
155homocysteine metabolic process (GO:0050667)2.81493073
156iron ion import (GO:0097286)2.81316468
157positive regulation of cholesterol transport (GO:0032376)2.81193386
158positive regulation of sterol transport (GO:0032373)2.81193386
159lateral sprouting from an epithelium (GO:0060601)2.81086508
160glucose catabolic process (GO:0006007)2.78230433
161negative regulation of lipid storage (GO:0010888)2.74487915
162smoothened signaling pathway (GO:0007224)2.74272132
163regulation of tolerance induction (GO:0002643)2.73831285
164regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.68964464
165centriole replication (GO:0007099)2.67069015
166microtubule-based process (GO:0007017)2.65438466
167rRNA catabolic process (GO:0016075)2.64725090
168sperm motility (GO:0030317)2.62739800
169retinol metabolic process (GO:0042572)2.59809283
170negative regulation of adaptive immune response (GO:0002820)2.58485804
171establishment of monopolar cell polarity (GO:0061162)2.57834189
172establishment or maintenance of monopolar cell polarity (GO:0061339)2.57834189
173antimicrobial humoral response (GO:0019730)2.56885568
174primary alcohol metabolic process (GO:0034308)2.56630350
175regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.54287361
176organelle assembly (GO:0070925)2.53654493
177multicellular organismal water homeostasis (GO:0050891)2.52265178
178regulation of collateral sprouting (GO:0048670)2.40310557
179hypotonic response (GO:0006971)2.35988028
180negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.35274425
181gas transport (GO:0015669)2.33225019
182regulation of apoptotic cell clearance (GO:2000425)2.32146449
183protein O-linked glycosylation (GO:0006493)2.31682223
184phosphatidylethanolamine biosynthetic process (GO:0006646)2.30250920
185carnitine transmembrane transport (GO:1902603)2.30125374
186axonemal dynein complex assembly (GO:0070286)19.3987906
187cilium movement (GO:0003341)16.2028158
188epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)14.7444707
189motile cilium assembly (GO:0044458)13.1766618
190epithelial cilium movement (GO:0003351)12.7522414
191axoneme assembly (GO:0035082)10.2995755

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.99883939
2MYB_21317192_ChIP-Seq_ERMYB_Mouse2.99438925
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.91788384
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.88884468
5* DROSHA_22980978_ChIP-Seq_HELA_Human2.59683552
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43023107
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.42643417
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42470034
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32268222
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.16502981
11AR_21909140_ChIP-Seq_LNCAP_Human2.13327512
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.00179468
13BP1_19119308_ChIP-ChIP_Hs578T_Human10.4127881
14VDR_24787735_ChIP-Seq_THP-1_Human1.97238146
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96642869
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95718543
17RXR_22158963_ChIP-Seq_LIVER_Mouse1.89469305
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.88927189
19NR3C1_21868756_ChIP-Seq_MCF10A_Human1.87058598
20BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86663148
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.82732872
22IRF8_21731497_ChIP-ChIP_J774_Mouse1.81900929
23AR_21572438_ChIP-Seq_LNCaP_Human1.78385777
24STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77700214
25LXR_22158963_ChIP-Seq_LIVER_Mouse1.75876673
26* VDR_22108803_ChIP-Seq_LS180_Human1.71814050
27SMAD4_21799915_ChIP-Seq_A2780_Human1.70770091
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69651920
29TP63_23658742_ChIP-Seq_EP156T_Human1.69407520
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.67507975
31IRF8_27001747_Chip-Seq_BMDM_Mouse1.66832592
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66106427
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.64618001
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64577030
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63721693
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63622842
37TP53_16413492_ChIP-PET_HCT116_Human1.60896673
38* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.59148684
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.55893363
40GATA4_25053715_ChIP-Seq_YYC3_Human1.52393411
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50923409
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.50428544
43* STAT3_23295773_ChIP-Seq_U87_Human1.50251278
44TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49716580
45SMRT_27268052_Chip-Seq_Bcells_Human1.44479611
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.43510307
47ER_23166858_ChIP-Seq_MCF-7_Human1.43049224
48TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.42674458
49ETV1_20927104_ChIP-Seq_GIST48_Human1.41763108
50ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41253400
51FOXM1_23109430_ChIP-Seq_U2OS_Human1.41167880
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40405990
53ZNF274_21170338_ChIP-Seq_K562_Hela1.40056824
54BCAT_22108803_ChIP-Seq_LS180_Human1.38395699
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37557111
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.37489331
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37101343
58AHR_22903824_ChIP-Seq_MCF-7_Human1.35961096
59* TP53_18474530_ChIP-ChIP_U2OS_Human1.33749092
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.33732100
61PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.33252785
62TAF15_26573619_Chip-Seq_HEK293_Human1.32967061
63SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31511713
64SCL_19346495_ChIP-Seq_HPC-7_Human1.29860275
65GBX2_23144817_ChIP-Seq_PC3_Human1.29654346
66GATA2_19941826_ChIP-Seq_K562_Human1.28732462
67TCF4_22108803_ChIP-Seq_LS180_Human1.28654783
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27815838
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.27367187
70* TCF4_23295773_ChIP-Seq_U87_Human1.26830555
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26407229
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25962540
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25384926
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24997502
75PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24922351
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24892861
77CTNNB1_20460455_ChIP-Seq_HCT116_Human1.24454984
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.24031931
79CBP_20019798_ChIP-Seq_JUKART_Human1.24031931
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23824608
81* FOXA1_25552417_ChIP-Seq_VCAP_Human1.23596444
82SMAD3_21741376_ChIP-Seq_HESCs_Human1.23247633
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.22862490
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22108530
85VDR_24763502_ChIP-Seq_THP-1_Human1.20258508
86EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18323391
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16702960
88PRDM14_20953172_ChIP-Seq_ESCs_Human1.16079045
89PHF8_20622853_ChIP-Seq_HELA_Human1.15816816
90* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15684110
91STAT1_20625510_ChIP-Seq_HELA_Human1.14605673
92ARNT_22903824_ChIP-Seq_MCF-7_Human1.14542374
93SMAD4_21741376_ChIP-Seq_EPCs_Human1.14307987
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14199232
95CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13751709
96RBPJ_21746931_ChIP-Seq_IB4_Human1.12507767
97* AR_25329375_ChIP-Seq_VCAP_Human1.12361344
98IRF8_22096565_ChIP-ChIP_GC-B_Human1.12161283
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12155200
100MYB_26560356_Chip-Seq_TH1_Human1.12144225
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11685937
102TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11558355
103HNFA_21074721_ChIP-Seq_CACO-2_Human1.11505380
104CDX2_22108803_ChIP-Seq_LS180_Human1.11304313
105PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10835822
106TCF7_22412390_ChIP-Seq_EML_Mouse1.10553408
107RUNX2_22187159_ChIP-Seq_PCA_Human1.10456608
108RUNX1_27514584_Chip-Seq_MCF-7_Human1.10401994
109FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.10070224
110GATA6_25053715_ChIP-Seq_YYC3_Human1.09657900
111EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09460545
112CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09264434
113GATA1_19941826_ChIP-Seq_K562_Human1.08707063
114GATA2_21666600_ChIP-Seq_HMVEC_Human1.08491288
115TDRD3_21172665_ChIP-Seq_MCF-7_Human1.08136226
116FOXA1_25329375_ChIP-Seq_VCAP_Human1.07413174
117FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07413174
118IGF1R_20145208_ChIP-Seq_DFB_Human1.07365270
119CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.07152764
120VDR_21846776_ChIP-Seq_THP-1_Human1.06761645
121EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06398480
122TBL1_22424771_ChIP-Seq_293T_Human1.05716674
123NFE2_27457419_Chip-Seq_LIVER_Mouse1.05662993
124NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05513319
125EWS_26573619_Chip-Seq_HEK293_Human1.05116403
126RUNX_20019798_ChIP-Seq_JUKART_Human1.05039654
127ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04441073
128NFYA_21822215_ChIP-Seq_K562_Human1.04225774
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.04142455
130P300_19829295_ChIP-Seq_ESCs_Human1.04115315
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03975241
132NFYB_21822215_ChIP-Seq_K562_Human1.03949016
133AR_20517297_ChIP-Seq_VCAP_Human1.03720631
134FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03608449
135EGR1_19032775_ChIP-ChIP_M12_Human1.02721894
136CEBPB_22108803_ChIP-Seq_LS180_Human1.02572513
137FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02408596
138PU_27001747_Chip-Seq_BMDM_Mouse1.01879272
139MYB_26560356_Chip-Seq_TH2_Human1.01009790
140FUS_26573619_Chip-Seq_HEK293_Human1.00534971
141TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98617986
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98507062
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98444712
144FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97884184
145FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.96862241
146UTX_26944678_Chip-Seq_JUKART_Human0.94782935
147ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90080496
148FOXA2_19822575_ChIP-Seq_HepG2_Human0.89520733
149GATA1_22025678_ChIP-Seq_K562_Human0.88554281
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88441340
151TBX20_22080862_ChIP-Seq_HEART_Mouse0.88280080
152TBX20_22328084_ChIP-Seq_HEART_Mouse0.88280080
153SPI1_23547873_ChIP-Seq_NB4_Human0.88083852
154E2F7_22180533_ChIP-Seq_HELA_Human0.87877871
155CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87580188
156CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87140576
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.87117070
158* PIAS1_25552417_ChIP-Seq_VCAP_Human0.85890683
159* GATA3_26560356_Chip-Seq_TH2_Human0.85884411
160SOX2_20726797_ChIP-Seq_SW620_Human0.85748949
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85194465
162RACK7_27058665_Chip-Seq_MCF-7_Human0.84789490
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84523347
164GATA3_27048872_Chip-Seq_THYMUS_Human0.83316322
165FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.83217858
166GATA1_19941827_ChIP-Seq_MEL_Mouse0.82717728
167LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82037557
168P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81805685
169NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80703826
170TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80250129
171KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79572485
172KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.78266281
173RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78196245
174STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77524483
175TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.76802415
176SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76611330

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology6.83979151
2MP0004043_abnormal_pH_regulation5.29541839
3MP0005377_hearing/vestibular/ear_phenot4.67319513
4MP0003878_abnormal_ear_physiology4.67319513
5MP0005360_urolithiasis4.43391236
6MP0002132_abnormal_respiratory_system4.33773072
7MP0003195_calcinosis3.93464712
8MP0002138_abnormal_hepatobiliary_system3.49496275
9MP0004019_abnormal_vitamin_homeostasis3.31650964
10MP0009643_abnormal_urine_homeostasis3.09809172
11MP0005332_abnormal_amino_acid3.09342499
12MP0001756_abnormal_urination3.09143963
13MP0001765_abnormal_ion_homeostasis3.06137940
14MP0005623_abnormal_meninges_morphology3.03319521
15MP0000383_abnormal_hair_follicle3.01334766
16MP0008875_abnormal_xenobiotic_pharmacok2.91475515
17MP0004133_heterotaxia2.90104053
18MP0009780_abnormal_chondrocyte_physiolo2.81928588
19MP0002136_abnormal_kidney_physiology2.59894229
20MP0003300_gastrointestinal_ulcer2.44477526
21MP0010678_abnormal_skin_adnexa2.36333655
22MP0001958_emphysema2.36051073
23MP0005636_abnormal_mineral_homeostasis2.20368260
24MP0003186_abnormal_redox_activity2.16279979
25MP0003656_abnormal_erythrocyte_physiolo2.07428492
26MP0002282_abnormal_trachea_morphology1.92898840
27MP0004264_abnormal_extraembryonic_tissu1.89129657
28MP0003252_abnormal_bile_duct1.79460002
29MP0002928_abnormal_bile_duct1.79423421
30MP0001764_abnormal_homeostasis1.77896895
31MP0005365_abnormal_bile_salt1.74595660
32MP0003183_abnormal_peptide_metabolism1.74557746
33MP0000465_gastrointestinal_hemorrhage1.73121164
34MP0008789_abnormal_olfactory_epithelium1.71812214
35MP0002877_abnormal_melanocyte_morpholog1.67946593
36MP0005451_abnormal_body_composition1.60208270
37MP0005499_abnormal_olfactory_system1.57661470
38MP0005394_taste/olfaction_phenotype1.57661470
39MP0002160_abnormal_reproductive_system1.57582757
40MP0000566_synostosis1.53773842
41MP0009046_muscle_twitch1.47332224
42MP0008057_abnormal_DNA_replication1.47247390
43MP0001346_abnormal_lacrimal_gland1.44454812
44MP0003303_peritoneal_inflammation1.39426367
45MP0005058_abnormal_lysosome_morphology1.37506643
46MP0003436_decreased_susceptibility_to1.35045185
47MP0006082_CNS_inflammation1.34252079
48MP0003950_abnormal_plasma_membrane1.23503950
49MP0000678_abnormal_parathyroid_gland1.23283998
50MP0002909_abnormal_adrenal_gland1.22865650
51MP0003172_abnormal_lysosome_physiology1.21934892
52MP0005551_abnormal_eye_electrophysiolog1.21792530
53MP0002139_abnormal_hepatobiliary_system1.21503046
54MP0009785_altered_susceptibility_to1.21458825
55MP0005395_other_phenotype1.21379424
56MP0005503_abnormal_tendon_morphology1.20927048
57MP0002419_abnormal_innate_immunity1.19889323
58MP0005253_abnormal_eye_physiology1.15607122
59MP0002876_abnormal_thyroid_physiology1.15257539
60MP0005083_abnormal_biliary_tract1.15218313
61MP0003566_abnormal_cell_adhesion1.13487146
62MP0002396_abnormal_hematopoietic_system1.13246845
63MP0000685_abnormal_immune_system1.12311180
64MP0000538_abnormal_urinary_bladder1.09754982
65MP0005310_abnormal_salivary_gland1.09333755
66MP0003638_abnormal_response/metabolism_1.06113730
67MP0001851_eye_inflammation1.05825823
68MP0005647_abnormal_sex_gland1.05362773
69MP0003045_fibrosis1.04393151
70MP0002135_abnormal_kidney_morphology1.03302016
71MP0005389_reproductive_system_phenotype1.03058628
72MP0008961_abnormal_basal_metabolism1.02929645
73MP0004808_abnormal_hematopoietic_stem1.02880635
74MP0010030_abnormal_orbit_morphology1.02391660
75MP0002168_other_aberrant_phenotype0.99978449
76MP0001845_abnormal_inflammatory_respons0.98942083
77MP0000343_altered_response_to0.98595709
78MP0004883_abnormal_blood_vessel0.98557867
79MP0000681_abnormal_thyroid_gland0.98528934
80MP0005166_decreased_susceptibility_to0.96724375
81MP0002638_abnormal_pupillary_reflex0.92324879
82MP0002998_abnormal_bone_remodeling0.91882113
83MP0005165_increased_susceptibility_to0.90461615
84MP0005319_abnormal_enzyme/_coenzyme0.89150082
85MP0009278_abnormal_bone_marrow0.89119444
86MP0005220_abnormal_exocrine_pancreas0.86912758
87MP0001984_abnormal_olfaction0.86294753
88MP0000569_abnormal_digit_pigmentation0.85154461
89MP0005535_abnormal_body_temperature0.84954729
90MP0001502_abnormal_circadian_rhythm0.83871413
91MP0001835_abnormal_antigen_presentation0.83527136
92MP0000427_abnormal_hair_cycle0.81478526
93MP0009764_decreased_sensitivity_to0.81422614
94MP0005464_abnormal_platelet_physiology0.80519478
95MP0003191_abnormal_cellular_cholesterol0.80480681
96MP0005167_abnormal_blood-brain_barrier0.80337345
97MP0004782_abnormal_surfactant_physiolog0.78802445
98MP0010155_abnormal_intestine_physiology0.78338138
99MP0002277_abnormal_respiratory_mucosa0.78271065
100MP0002734_abnormal_mechanical_nocicepti0.77313544
101MP0008872_abnormal_physiological_respon0.76852166
102MP0009765_abnormal_xenobiotic_induced0.76612646
103MP0002254_reproductive_system_inflammat0.76227197
104MP0005164_abnormal_response_to0.76202601
105MP0005584_abnormal_enzyme/coenzyme_acti0.75936031
106MP0002229_neurodegeneration0.75225001
107MP0002405_respiratory_system_inflammati0.73407882
108MP0002735_abnormal_chemical_nociception0.72543556
109MP0004885_abnormal_endolymph0.72222646
110MP0003786_premature_aging0.72136122
111MP0008469_abnormal_protein_level0.72011086
112MP0005408_hypopigmentation0.72000085
113MP0000230_abnormal_systemic_arterial0.71991760
114MP0005085_abnormal_gallbladder_physiolo0.71746730
115MP0002332_abnormal_exercise_endurance0.71441519
116MP0005388_respiratory_system_phenotype0.69575258
117MP0002133_abnormal_respiratory_system0.69575258
118MP0001324_abnormal_eye_pigmentation0.68979317
119MP0002896_abnormal_bone_mineralization0.67911212
120MP0001270_distended_abdomen0.67810732
121MP0001664_abnormal_digestion0.67000937
122MP0001929_abnormal_gametogenesis0.66449701
123MP0003698_abnormal_male_reproductive0.66392406
124MP0005248_abnormal_Harderian_gland0.66389817
125MP0004147_increased_porphyrin_level0.66229254
126MP0005387_immune_system_phenotype0.66032965
127MP0001790_abnormal_immune_system0.66032965
128MP0003690_abnormal_glial_cell0.65592524
129MP0005376_homeostasis/metabolism_phenot0.64878051
130MP0000377_abnormal_hair_follicle0.64403703
131MP0002233_abnormal_nose_morphology0.63924437
132MP0005025_abnormal_response_to0.63332060
133MP0003866_abnormal_defecation0.63208446
134MP0005645_abnormal_hypothalamus_physiol0.62623615
135MP0005195_abnormal_posterior_eye0.62101868
136MP0003828_pulmonary_edema0.61318359
137MP0009763_increased_sensitivity_to0.61201710
138MP0001879_abnormal_lymphatic_vessel0.61070858
139MP0003724_increased_susceptibility_to0.59804034
140MP0002249_abnormal_larynx_morphology0.59512182
141MP0001177_atelectasis0.59069533
142MP0001533_abnormal_skeleton_physiology0.58941843
143MP0004742_abnormal_vestibular_system0.57809945
144MP0003075_altered_response_to0.57186638
145MP0002089_abnormal_postnatal_growth/wei0.56804886
146MP0000858_altered_metastatic_potential0.56492460
147MP0000762_abnormal_tongue_morphology0.56089209
148MP0001191_abnormal_skin_condition0.56019797
149MP0003943_abnormal_hepatobiliary_system0.54307516
150MP0001216_abnormal_epidermal_layer0.54219464
151MP0003890_abnormal_embryonic-extraembry0.54092331
152MP0000631_abnormal_neuroendocrine_gland0.52996326
153MP0001485_abnormal_pinna_reflex0.52137221
154MP0005646_abnormal_pituitary_gland0.52013757
155MP0004215_abnormal_myocardial_fiber0.51848759
156MP0001663_abnormal_digestive_system0.51806893
157MP0000026_abnormal_inner_ear0.51617092
158MP0003795_abnormal_bone_structure0.51484542

Predicted human phenotypes

RankGene SetZ-score
1Rhinitis (HP:0012384)9.74250548
2Increased circulating renin level (HP:0000848)8.76811294
3Hypokalemic alkalosis (HP:0001949)8.72640977
4Metabolic alkalosis (HP:0200114)8.49215069
5Hyperactive renin-angiotensin system (HP:0000841)7.27879321
6Hypomagnesemia (HP:0002917)7.20630513
7Bronchiectasis (HP:0002110)7.17442712
8Chronic bronchitis (HP:0004469)7.17353517
9Polyuria (HP:0000103)6.93498516
10Abnormality of chloride homeostasis (HP:0011422)6.85792400
11Abnormal urine output (HP:0012590)6.38242172
12Nasal polyposis (HP:0100582)6.25669156
13Tetany (HP:0001281)5.99732061
14Abnormality of renal excretion (HP:0011036)5.87657143
15Abnormality of magnesium homeostasis (HP:0004921)5.84657306
16Abnormal drinking behavior (HP:0030082)5.79458204
17Polydipsia (HP:0001959)5.79458204
18Hyperaldosteronism (HP:0000859)5.32493328
19Renal salt wasting (HP:0000127)5.28649330
20Abnormality of renin-angiotensin system (HP:0000847)5.20841508
21Abnormality of the nasal mucosa (HP:0000433)5.12265668
22Alkalosis (HP:0001948)5.01577303
23Gout (HP:0001997)4.80048954
24Recurrent sinusitis (HP:0011108)4.45020018
25Bronchitis (HP:0012387)4.41430696
26Proximal tubulopathy (HP:0000114)4.26380071
27Chronic sinusitis (HP:0011109)4.03698955
28Hypokalemia (HP:0002900)4.02973150
29Pancreatic fibrosis (HP:0100732)3.85818884
30Eczematoid dermatitis (HP:0000976)3.85237235
31Infertility (HP:0000789)3.77584971
32True hermaphroditism (HP:0010459)3.69937530
33Recurrent otitis media (HP:0000403)3.63136710
34Hyperuricemia (HP:0002149)3.60605314
35Increased purine levels (HP:0004368)3.60605314
36Abnormal tarsal ossification (HP:0008369)3.48631917
37Occipital encephalocele (HP:0002085)3.43027663
38Abnormality of potassium homeostasis (HP:0011042)3.35999537
39Pancreatic cysts (HP:0001737)3.33376138
40Male infertility (HP:0003251)3.27946931
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.26140690
42Abnormality of midbrain morphology (HP:0002418)3.23934590
43Molar tooth sign on MRI (HP:0002419)3.23934590
44Abnormality of purine metabolism (HP:0004352)3.21015643
45Renal tubular acidosis (HP:0001947)3.20470596
46Chronic hepatic failure (HP:0100626)3.20047797
47Abnormal foot bone ossification (HP:0010675)3.19851520
48Hypercalciuria (HP:0002150)3.16234771
49Urethral obstruction (HP:0000796)3.15394642
50Nephronophthisis (HP:0000090)3.14018146
51Chronic otitis media (HP:0000389)3.10265382
52Cystic liver disease (HP:0006706)3.05365356
53Facial shape deformation (HP:0011334)2.91027381
54Potter facies (HP:0002009)2.91027381
55Recurrent abscess formation (HP:0002722)2.84733512
56Hyperglycinuria (HP:0003108)2.84409260
57Abnormality of sodium homeostasis (HP:0010931)2.78296238
58Recurrent gram-negative bacterial infections (HP:0005420)2.66536669
59Hydroxyprolinuria (HP:0003080)2.63214117
60Abnormality of proline metabolism (HP:0010907)2.63214117
61Recurrent bacterial skin infections (HP:0005406)2.59212754
62Abnormality of the renal medulla (HP:0100957)2.58463517
63Postaxial foot polydactyly (HP:0001830)2.57131622
64Metaphyseal irregularity (HP:0003025)2.54547351
65Hyponatremia (HP:0002902)2.52843580
66Tubulointerstitial nephritis (HP:0001970)2.52657087
67Recurrent bronchitis (HP:0002837)2.51733757
68Nephrocalcinosis (HP:0000121)2.47247359
69Mediastinal lymphadenopathy (HP:0100721)2.40644990
70Generalized aminoaciduria (HP:0002909)2.40309734
71Dehydration (HP:0001944)2.36478023
72Bilateral sensorineural hearing impairment (HP:0008619)2.36467055
73Adrenal overactivity (HP:0002717)2.36227716
74Atelectasis (HP:0100750)2.34930693
75Abnormality of nucleobase metabolism (HP:0010932)2.33249203
76Abnormality of fatty-acid metabolism (HP:0004359)2.32549972
77Congenital hepatic fibrosis (HP:0002612)2.32474169
78Tubulointerstitial fibrosis (HP:0005576)2.32377157
79Abnormality of macrophages (HP:0004311)2.23611156
80Chondrocalcinosis (HP:0000934)2.23533197
81Aplasia/Hypoplasia of the tongue (HP:0010295)2.19549536
82Enlarged kidneys (HP:0000105)2.18712206
83Abnormality of Sharpey fibers (HP:0100685)2.18468273
84Medial flaring of the eyebrow (HP:0010747)2.16486614
85Gingivitis (HP:0000230)2.10359444
86Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09392499
87Abnormality of glycine metabolism (HP:0010895)2.06323351
88Abnormality of serine family amino acid metabolism (HP:0010894)2.06323351
89Metaphyseal cupping (HP:0003021)2.04151707
90Anencephaly (HP:0002323)2.02724233
91Abnormality of urine glucose concentration (HP:0011016)2.02571064
92Glycosuria (HP:0003076)2.02571064
93Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.9830180
94Abnormal ciliary motility (HP:0012262)10.9937090
95Absent/shortened dynein arms (HP:0200106)10.9516615
96Dynein arm defect of respiratory motile cilia (HP:0012255)10.9516615
97Abnormal respiratory motile cilium physiology (HP:0012261)10.8485158
98Abnormal respiratory epithelium morphology (HP:0012253)10.7826476
99Abnormal respiratory motile cilium morphology (HP:0005938)10.7826476
100Flat acetabular roof (HP:0003180)1.99521328
101Stillbirth (HP:0003826)1.98020983
102Male pseudohermaphroditism (HP:0000037)1.95155683
103Abnormality of carpal bone ossification (HP:0006257)1.94633023
104Obstructive lung disease (HP:0006536)1.94236315
105Chronic obstructive pulmonary disease (HP:0006510)1.94236315
106Congenital primary aphakia (HP:0007707)1.93840960
107Furrowed tongue (HP:0000221)1.93715235
108Abnormality of aspartate family amino acid metabolism (HP:0010899)1.92251691
109Tubular atrophy (HP:0000092)1.91674095
110Absent frontal sinuses (HP:0002688)1.91351452
111Gait imbalance (HP:0002141)1.90680476
112Aplasia/Hypoplasia of the spleen (HP:0010451)1.89415400
113Asplenia (HP:0001746)1.89145165
114Vacuolated lymphocytes (HP:0001922)1.87680017
115Bell-shaped thorax (HP:0001591)1.80822805
116Abnormality of the renal cortex (HP:0011035)1.80039171
117Sclerocornea (HP:0000647)1.77865591
118Delayed epiphyseal ossification (HP:0002663)1.77416711
119Oculomotor apraxia (HP:0000657)1.73735228
120Renal tubular dysfunction (HP:0000124)1.71689503
121Nephrogenic diabetes insipidus (HP:0009806)1.69633427
122Nephropathy (HP:0000112)1.68960124
123Abnormal platelet function (HP:0011869)1.68557778
124Impaired platelet aggregation (HP:0003540)1.68557778
125Abnormal ossification of hand bones (HP:0005921)1.64391379
126Hyperkalemia (HP:0002153)1.64286785
127Postaxial hand polydactyly (HP:0001162)1.64281114
128Ketoacidosis (HP:0001993)1.62260852
129Decreased central vision (HP:0007663)1.62153954
130Generalized muscle weakness (HP:0003324)1.61179674
131Cone-rod dystrophy (HP:0000548)1.61004481
132Confusion (HP:0001289)1.60831319
133Hypophosphatemia (HP:0002148)1.60548670
134Nephrolithiasis (HP:0000787)1.59487288
135Vascular calcification (HP:0004934)1.58725762
136Abnormal hand bone ossification (HP:0010660)1.57995335
137Decreased circulating renin level (HP:0003351)1.57491815
138Abnormality of alkaline phosphatase activity (HP:0004379)1.54850207
139Abnormal enzyme/coenzyme activity (HP:0012379)1.54711604
140Lip pit (HP:0100267)1.54508680
141Abnormal rod and cone electroretinograms (HP:0008323)1.53012856
142Rickets (HP:0002748)1.52065247
143Hypotension (HP:0002615)1.51809829
144Submucous cleft hard palate (HP:0000176)1.50717846
145Hyperphosphaturia (HP:0003109)1.50280698
146Entropion (HP:0000621)1.50269298
147Abnormal urine phosphate concentration (HP:0012599)1.49507880
148Recurrent fungal infections (HP:0002841)1.49076308
149Tubulointerstitial abnormality (HP:0001969)1.47551459
150Cellulitis (HP:0100658)1.47291631
151Recurrent skin infections (HP:0001581)1.46066354
152IgM deficiency (HP:0002850)1.44983490
153Cupped ribs (HP:0000887)1.44964115
154Osteolytic defects of the hand bones (HP:0009699)1.44701936
155Osteolytic defects of the phalanges of the hand (HP:0009771)1.44701936
156Upper limb muscle weakness (HP:0003484)1.44461873
157Distal lower limb muscle weakness (HP:0009053)1.44103142
158Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.42477028
159Median cleft lip (HP:0000161)1.39606912
160Preaxial hand polydactyly (HP:0001177)1.38154295
161Genital tract atresia (HP:0001827)1.37986278
162Vaginal atresia (HP:0000148)1.37370440
163Poor coordination (HP:0002370)1.36592242
164Abnormal biliary tract physiology (HP:0012439)1.31708703
165Bile duct proliferation (HP:0001408)1.31708703
166Abnormality of macular pigmentation (HP:0008002)1.31661843
167Short thorax (HP:0010306)1.23871665
168Central scotoma (HP:0000603)1.21056006
169Stage 5 chronic kidney disease (HP:0003774)1.19551741
170Glucose intolerance (HP:0000833)1.18984207
171Supernumerary spleens (HP:0009799)1.17707180
172Abnormality of the frontal sinuses (HP:0002687)1.17677349
173Abnormality of permanent molar morphology (HP:0011071)1.14535419
174Abnormality of the dental root (HP:0006486)1.14535419
175Taurodontia (HP:0000679)1.14535419
176Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.14462403
177Absent speech (HP:0001344)1.11693305
178Abnormality of the dental pulp (HP:0006479)1.10734297
179Retinitis pigmentosa (HP:0000510)1.10733211
180Hip dysplasia (HP:0001385)1.06253564
181Portal hypertension (HP:0001409)1.05807133
182Abnormality of molar morphology (HP:0011070)1.04648795
183Abnormality of molar (HP:0011077)1.04648795
184Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.04479412
185Renal dysplasia (HP:0000110)1.01823556
186Alveolar cell carcinoma (HP:0006519)1.01534213
187Spinal muscular atrophy (HP:0007269)0.99168337
188Narrow forehead (HP:0000341)0.98685359
189Prominent nasal bridge (HP:0000426)0.98191991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK159.48664570
2WNK37.51633575
3WNK47.43307091
4OXSR17.28229015
5STK394.38042290
6EPHA23.20959706
7FRK3.16814448
8IRAK43.10090537
9MAP3K22.25226840
10EPHB12.17764461
11BCR1.97212564
12MAP2K31.70192935
13PTK2B1.69957312
14NME11.62353521
15TLK11.55379150
16SGK4941.55310005
17SGK2231.55310005
18STK38L1.49349650
19SGK21.42721983
20WNK11.35802290
21STK101.34734994
22EPHA31.33084715
23IRAK11.30800214
24MAP3K71.27749158
25ACVR1B1.27214624
26ADRBK21.26072108
27SGK31.25837914
28BMPR1B1.25466286
29TNK21.22480444
30BRSK21.20369851
31TRPM71.11329679
32BTK1.08819794
33MAP3K141.07345799
34MAP3K61.03225634
35ERBB31.01829607
36MAP2K60.99587118
37CAMKK20.98187971
38GRK60.96165402
39GRK10.95938688
40EEF2K0.92914444
41NLK0.91066144
42MAP3K40.90987790
43PINK10.90203918
44FER0.90034495
45ERBB20.86960759
46LRRK20.86659419
47NUAK10.86259529
48BCKDK0.85189029
49IRAK30.84600328
50TEC0.81342207
51PBK0.79394256
52MAP3K90.75692880
53MAPK130.74850872
54FGFR30.74713505
55KIT0.73090866
56MAP4K20.72696804
57ADRBK10.71577484
58LATS10.71401254
59RIPK10.68573771
60FES0.67215146
61MARK20.66138297
62MAP4K10.65837953
63TGFBR10.65609666
64IKBKE0.64309519
65PRKCQ0.63812894
66CAMKK10.63273847
67PAK40.63014572
68MST40.62937138
69BLK0.62340326
70MAP3K30.62031963
71RIPK40.61342487
72TXK0.61284935
73PNCK0.60728544
74CSK0.59918306
75HIPK20.59746598
76PIK3CG0.58741277
77TAOK30.58583995
78ERN10.56329802
79TBK10.55261373
80PRKCI0.53693320
81SGK10.52244145
82MKNK20.50683261
83CLK10.49772818
84DYRK30.49518707
85MAPK110.49273858
86PRKAA20.47836595
87PIM10.47621692
88MAPKAPK50.46084727
89PIK3CA0.45908563
90CAMK1D0.45278043
91CHUK0.44104146
92STK40.43641459
93STK380.43444161
94JAK10.43244648
95STK110.42885778
96TESK10.42029024
97NEK20.40727341
98TTN0.40392375
99PRKCD0.40246206
100MST1R0.39731758
101PRKCE0.39213763
102GSK3A0.39123878
103MAPK40.38577083
104SYK0.37857479
105CAMK1G0.37697038
106NEK10.37268826
107AKT30.36950215
108PRKAA10.36942780
109CDK60.35616922
110PAK30.35353437
111CSNK1A1L0.34954492
112INSRR0.34216651
113EGFR0.33123838
114NEK90.32851154
115TTK0.32617090
116MAPKAPK30.31798725
117PTK60.31112044
118DYRK1B0.30342996
119LYN0.28977168
120IKBKB0.28351940
121PRKACA0.28224776
122LIMK10.27997516
123PRKCA0.27798718
124HCK0.27665424
125IGF1R0.26160753
126STK30.25782154
127ABL10.25566604
128ERBB40.25076105
129BMPR20.24549806
130RET0.22994063
131TGFBR20.22807458
132JAK20.22367554
133SMG10.21968712
134FYN0.21935438
135ZAK0.21740794
136MET0.21518237
137PTK20.20981337
138MAP2K40.20884567
139PDK40.20038481
140PDK30.20038481
141TIE10.19392507
142JAK30.16284244
143CDK120.16040245
144PRKCH0.15839518
145NEK60.15552293
146RPS6KA10.15306794
147ALK0.14750429
148ATR0.14694031
149PDPK10.14351431
150TYK20.14288234
151FGFR40.13730959
152TAOK10.13569384
153ITK0.13083003
154STK240.12849129
155KDR0.12116347

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose and glucuronate interconversions_Homo sapiens_hsa000404.68709302
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000534.45387217
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.46213291
4Linoleic acid metabolism_Homo sapiens_hsa005912.94444643
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.84364432
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.60871953
7Butanoate metabolism_Homo sapiens_hsa006502.55825627
8Vitamin digestion and absorption_Homo sapiens_hsa049772.52156570
9Huntingtons disease_Homo sapiens_hsa050162.44707342
10Glutathione metabolism_Homo sapiens_hsa004802.34850853
11Tyrosine metabolism_Homo sapiens_hsa003502.28117875
12Starch and sucrose metabolism_Homo sapiens_hsa005002.19134277
13Collecting duct acid secretion_Homo sapiens_hsa049662.14657329
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.95833443
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91193681
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.86419779
17Sulfur metabolism_Homo sapiens_hsa009201.83183383
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.74403908
19Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.66680240
20Peroxisome_Homo sapiens_hsa041461.62694752
21Sphingolipid metabolism_Homo sapiens_hsa006001.61134112
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.59205706
23Salivary secretion_Homo sapiens_hsa049701.57143103
24Propanoate metabolism_Homo sapiens_hsa006401.55005304
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.54263209
26Asthma_Homo sapiens_hsa053101.52974244
27beta-Alanine metabolism_Homo sapiens_hsa004101.48221973
28Histidine metabolism_Homo sapiens_hsa003401.47775739
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47020768
30Other glycan degradation_Homo sapiens_hsa005111.44114513
31Fatty acid degradation_Homo sapiens_hsa000711.42932838
32Leishmaniasis_Homo sapiens_hsa051401.42274137
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.39818337
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34823748
35Bile secretion_Homo sapiens_hsa049761.33451682
36Mineral absorption_Homo sapiens_hsa049781.30647037
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.26481641
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22833637
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21729074
40Circadian rhythm_Homo sapiens_hsa047101.20280818
41Pentose phosphate pathway_Homo sapiens_hsa000301.19783993
42Chemical carcinogenesis_Homo sapiens_hsa052041.18513080
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17608665
44Lysine degradation_Homo sapiens_hsa003101.12286267
45Nitrogen metabolism_Homo sapiens_hsa009101.11849413
46Phototransduction_Homo sapiens_hsa047441.11376049
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10023177
48Allograft rejection_Homo sapiens_hsa053301.08394068
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07055168
50Graft-versus-host disease_Homo sapiens_hsa053321.05334172
51Pyruvate metabolism_Homo sapiens_hsa006201.04748668
52Type I diabetes mellitus_Homo sapiens_hsa049401.03775314
53Tryptophan metabolism_Homo sapiens_hsa003801.03585366
54Autoimmune thyroid disease_Homo sapiens_hsa053201.02909302
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00816614
56Retinol metabolism_Homo sapiens_hsa008300.96688486
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95727358
58Protein digestion and absorption_Homo sapiens_hsa049740.90051468
59Olfactory transduction_Homo sapiens_hsa047400.88858296
60Tuberculosis_Homo sapiens_hsa051520.88802683
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87705478
62Taste transduction_Homo sapiens_hsa047420.87604437
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87104601
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.85215886
65Arachidonic acid metabolism_Homo sapiens_hsa005900.84507088
66Thyroid hormone synthesis_Homo sapiens_hsa049180.84500638
67Rheumatoid arthritis_Homo sapiens_hsa053230.83063416
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.83005228
69Carbon metabolism_Homo sapiens_hsa012000.82353043
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80720855
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80523373
72* ABC transporters_Homo sapiens_hsa020100.80318397
73Tight junction_Homo sapiens_hsa045300.80127186
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75812541
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75245971
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.74339086
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73772152
78Phagosome_Homo sapiens_hsa041450.71883709
79Pertussis_Homo sapiens_hsa051330.69971377
80Complement and coagulation cascades_Homo sapiens_hsa046100.68907430
81Ether lipid metabolism_Homo sapiens_hsa005650.68076451
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.66766855
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66408252
84Nicotine addiction_Homo sapiens_hsa050330.65559489
85Glycerolipid metabolism_Homo sapiens_hsa005610.64918579
86Galactose metabolism_Homo sapiens_hsa000520.64474833
87Fatty acid metabolism_Homo sapiens_hsa012120.63877727
88Lysosome_Homo sapiens_hsa041420.63592224
89Serotonergic synapse_Homo sapiens_hsa047260.63009221
90Regulation of autophagy_Homo sapiens_hsa041400.62129627
91PPAR signaling pathway_Homo sapiens_hsa033200.61845471
92Renin-angiotensin system_Homo sapiens_hsa046140.59651571
93Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59560652
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59472937
95Caffeine metabolism_Homo sapiens_hsa002320.58748277
96Arginine and proline metabolism_Homo sapiens_hsa003300.58643692
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58067220
98Inositol phosphate metabolism_Homo sapiens_hsa005620.57841701
99Antigen processing and presentation_Homo sapiens_hsa046120.55757781
100FoxO signaling pathway_Homo sapiens_hsa040680.55285745
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54072794
102Calcium signaling pathway_Homo sapiens_hsa040200.53783148
103Osteoclast differentiation_Homo sapiens_hsa043800.52094121
104Hematopoietic cell lineage_Homo sapiens_hsa046400.52076562
105Selenocompound metabolism_Homo sapiens_hsa004500.51140346
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50546522
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49957963
108Gastric acid secretion_Homo sapiens_hsa049710.49114189
109Phenylalanine metabolism_Homo sapiens_hsa003600.47023743
110Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45648150
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45273132
112Salmonella infection_Homo sapiens_hsa051320.45033734
113Hepatitis C_Homo sapiens_hsa051600.44661895
114Malaria_Homo sapiens_hsa051440.42369231
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41480207
116Staphylococcus aureus infection_Homo sapiens_hsa051500.41279960
117Insulin resistance_Homo sapiens_hsa049310.40377599
118African trypanosomiasis_Homo sapiens_hsa051430.39749015
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.39650324
120cAMP signaling pathway_Homo sapiens_hsa040240.38005919
121Choline metabolism in cancer_Homo sapiens_hsa052310.37976957
122Legionellosis_Homo sapiens_hsa051340.37425905
123Pancreatic cancer_Homo sapiens_hsa052120.36922909
124Bladder cancer_Homo sapiens_hsa052190.36796350
125Pancreatic secretion_Homo sapiens_hsa049720.36221932
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.35251247
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35221956
128Biosynthesis of amino acids_Homo sapiens_hsa012300.32740080
129Folate biosynthesis_Homo sapiens_hsa007900.32594579
130Amoebiasis_Homo sapiens_hsa051460.31629938
131Shigellosis_Homo sapiens_hsa051310.31393028
132Dorso-ventral axis formation_Homo sapiens_hsa043200.31261208
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31104074
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30375429
135Chemokine signaling pathway_Homo sapiens_hsa040620.30245239
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29955826
137Toxoplasmosis_Homo sapiens_hsa051450.29946469
138Endometrial cancer_Homo sapiens_hsa052130.29635556
139Influenza A_Homo sapiens_hsa051640.29580936
140TNF signaling pathway_Homo sapiens_hsa046680.29571157
141Fatty acid biosynthesis_Homo sapiens_hsa000610.29092053
142Ovarian steroidogenesis_Homo sapiens_hsa049130.26884495
143Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.23860677
144Systemic lupus erythematosus_Homo sapiens_hsa053220.22255708
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.21377348
146Notch signaling pathway_Homo sapiens_hsa043300.20358776
147Maturity onset diabetes of the young_Homo sapiens_hsa049500.19954272
148Renin secretion_Homo sapiens_hsa049240.19122881
149Adherens junction_Homo sapiens_hsa045200.19028499
150Type II diabetes mellitus_Homo sapiens_hsa049300.17389755

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