ABCA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.60181228
2L-phenylalanine catabolic process (GO:0006559)5.55775709
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.55775709
4L-phenylalanine metabolic process (GO:0006558)5.34380432
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.34380432
6surfactant homeostasis (GO:0043129)5.27483137
7cysteine metabolic process (GO:0006534)5.15876867
8aromatic amino acid family catabolic process (GO:0009074)4.92177124
9synaptic vesicle maturation (GO:0016188)4.73297825
10lysine metabolic process (GO:0006553)4.73076536
11lysine catabolic process (GO:0006554)4.73076536
12alpha-linolenic acid metabolic process (GO:0036109)4.67993636
13glyoxylate metabolic process (GO:0046487)4.64317405
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.59714678
15regulation of synaptic vesicle exocytosis (GO:2000300)4.50160810
16drug transmembrane transport (GO:0006855)4.47456780
17glutamate secretion (GO:0014047)4.42952557
18indole-containing compound catabolic process (GO:0042436)4.41378835
19indolalkylamine catabolic process (GO:0046218)4.41378835
20tryptophan catabolic process (GO:0006569)4.41378835
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34859726
22chemical homeostasis within a tissue (GO:0048875)4.30255655
23drug catabolic process (GO:0042737)4.29537475
24urate metabolic process (GO:0046415)4.26682282
25tryptophan metabolic process (GO:0006568)4.19268139
26kynurenine metabolic process (GO:0070189)4.17812562
27sulfur amino acid catabolic process (GO:0000098)4.17229444
28sodium ion export (GO:0071436)4.13183467
29locomotory exploration behavior (GO:0035641)4.07656310
30phosphate ion transport (GO:0006817)4.06039033
31bile acid biosynthetic process (GO:0006699)4.02717665
32phosphate ion transmembrane transport (GO:0035435)4.01782986
33synaptic vesicle exocytosis (GO:0016079)3.98946450
34urea metabolic process (GO:0019627)3.97933880
35urea cycle (GO:0000050)3.97933880
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.91583288
37cellular potassium ion homeostasis (GO:0030007)3.90301969
38cellular ketone body metabolic process (GO:0046950)3.89970471
39protein carboxylation (GO:0018214)3.86099149
40peptidyl-glutamic acid carboxylation (GO:0017187)3.86099149
41homocysteine metabolic process (GO:0050667)3.85118970
42exogenous drug catabolic process (GO:0042738)3.84782441
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.81814273
44regulation of cholesterol homeostasis (GO:2000188)3.77867873
45vocalization behavior (GO:0071625)3.77311677
46glutamate metabolic process (GO:0006536)3.74844933
47serine family amino acid catabolic process (GO:0009071)3.74517638
48complement activation, alternative pathway (GO:0006957)3.68038353
49drug transport (GO:0015893)3.66259516
50cytoskeletal anchoring at plasma membrane (GO:0007016)3.65593502
51cellular response to nitric oxide (GO:0071732)3.65514798
52short-chain fatty acid metabolic process (GO:0046459)3.65043791
53amino-acid betaine metabolic process (GO:0006577)3.64252360
54nitrogen cycle metabolic process (GO:0071941)3.62812498
55regulation of synaptic vesicle transport (GO:1902803)3.62198839
56negative regulation of fibrinolysis (GO:0051918)3.61468879
57cellular modified amino acid catabolic process (GO:0042219)3.60341023
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59719461
59positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.58139909
60exploration behavior (GO:0035640)3.55245275
61neuronal ion channel clustering (GO:0045161)3.55094303
62bile acid metabolic process (GO:0008206)3.53579685
63aromatic amino acid family metabolic process (GO:0009072)3.51645190
64high-density lipoprotein particle remodeling (GO:0034375)3.48929917
65ethanol oxidation (GO:0006069)3.46295461
66regulation of protein activation cascade (GO:2000257)3.45321505
67cellular sodium ion homeostasis (GO:0006883)3.44225572
68layer formation in cerebral cortex (GO:0021819)3.44078499
69cerebellar granule cell differentiation (GO:0021707)3.43952675
70positive regulation of synapse maturation (GO:0090129)3.43520646
71alpha-amino acid catabolic process (GO:1901606)3.41705281
72regulation of neuronal synaptic plasticity (GO:0048168)3.39395383
73dicarboxylic acid biosynthetic process (GO:0043650)3.37196408
74negative regulation of cholesterol transport (GO:0032375)3.35004557
75negative regulation of sterol transport (GO:0032372)3.35004557
76postsynaptic membrane organization (GO:0001941)3.34972560
77ketone body metabolic process (GO:1902224)3.33975397
78peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.33906631
79cell migration in hindbrain (GO:0021535)3.30369785
80neurotransmitter secretion (GO:0007269)3.30340516
81L-amino acid import (GO:0043092)3.30164817
82dendritic spine morphogenesis (GO:0060997)3.29515717
83tyrosine metabolic process (GO:0006570)3.28939950
84phospholipid homeostasis (GO:0055091)3.28557629
85cellular amino acid catabolic process (GO:0009063)3.28414778
86acetyl-CoA metabolic process (GO:0006084)3.26569663
87regulation of complement activation (GO:0030449)3.26262349
88regulation of fibrinolysis (GO:0051917)3.26200560
89auditory behavior (GO:0031223)3.26181807
90response to mercury ion (GO:0046689)3.25481161
91regulation of synapse structural plasticity (GO:0051823)3.25430717
92fatty acid beta-oxidation (GO:0006635)3.25289912
93aspartate family amino acid catabolic process (GO:0009068)3.24654761
94neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.24395369
95reverse cholesterol transport (GO:0043691)3.19932665
96dendritic spine organization (GO:0097061)3.19561212
97fatty acid oxidation (GO:0019395)3.18752910
98cholesterol efflux (GO:0033344)3.18427570
99membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.16421330
100indolalkylamine metabolic process (GO:0006586)3.14398405
101neuromuscular process controlling balance (GO:0050885)3.14397606
102lipid oxidation (GO:0034440)3.13766699
103mating behavior (GO:0007617)3.12601487
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.11341011
105benzene-containing compound metabolic process (GO:0042537)3.09577579
106amino acid import (GO:0043090)3.08341242
107flavonoid metabolic process (GO:0009812)3.07764934
108regulation of glutamate receptor signaling pathway (GO:1900449)3.06715504
109ionotropic glutamate receptor signaling pathway (GO:0035235)3.06478743
1102-oxoglutarate metabolic process (GO:0006103)3.06008132
111monocarboxylic acid catabolic process (GO:0072329)3.05256187
112serine family amino acid metabolic process (GO:0009069)3.01648658
113fatty acid catabolic process (GO:0009062)3.00915689
114coenzyme catabolic process (GO:0009109)3.00644433
115plasma lipoprotein particle clearance (GO:0034381)3.00420827
116regulation of triglyceride catabolic process (GO:0010896)3.00046199
117organic acid catabolic process (GO:0016054)2.98563131
118carboxylic acid catabolic process (GO:0046395)2.98563131
119triglyceride homeostasis (GO:0070328)2.97823932
120acylglycerol homeostasis (GO:0055090)2.97823932
121sodium-independent organic anion transport (GO:0043252)2.97674107
122cellular glucuronidation (GO:0052695)2.97667279
123neuron cell-cell adhesion (GO:0007158)2.97460579
124protein-lipid complex remodeling (GO:0034368)2.96870325
125macromolecular complex remodeling (GO:0034367)2.96870325
126plasma lipoprotein particle remodeling (GO:0034369)2.96870325
127regulation of synapse maturation (GO:0090128)2.95916655
128phospholipid efflux (GO:0033700)2.95400493
129neurotransmitter-gated ion channel clustering (GO:0072578)2.94186397
130valine metabolic process (GO:0006573)2.93306772
131drug metabolic process (GO:0017144)2.92725514
132bile acid and bile salt transport (GO:0015721)2.92413793
133regulation of ARF protein signal transduction (GO:0032012)2.91842663
134semaphorin-plexin signaling pathway (GO:0071526)2.91279360
135tricarboxylic acid metabolic process (GO:0072350)2.89400925
136respiratory gaseous exchange (GO:0007585)2.87405729
137very long-chain fatty acid metabolic process (GO:0000038)2.86919899
138cell communication by electrical coupling (GO:0010644)2.86378906
139activation of protein kinase A activity (GO:0034199)2.86325653
140cerebellar Purkinje cell layer development (GO:0021680)2.85920299
141regulation of cholesterol biosynthetic process (GO:0045540)2.85801130
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.83878775
143carnitine metabolic process (GO:0009437)2.82544995
144regulation of cholesterol esterification (GO:0010872)2.80965631
145cellular biogenic amine catabolic process (GO:0042402)2.78959702
146amine catabolic process (GO:0009310)2.78959702
147pyrimidine nucleobase catabolic process (GO:0006208)2.76403184
148establishment of nucleus localization (GO:0040023)2.76387383
149positive regulation of fatty acid beta-oxidation (GO:0032000)2.76028542
150positive regulation of lipid catabolic process (GO:0050996)2.75841489
151glucuronate metabolic process (GO:0019585)2.75707128
152regulation of synaptic plasticity (GO:0048167)2.73273058
153synaptic vesicle endocytosis (GO:0048488)2.71358685
154potassium ion homeostasis (GO:0055075)2.69370974
155neuron recognition (GO:0008038)2.68679635
156negative regulation of dendrite morphogenesis (GO:0050774)2.65816496
157neuron remodeling (GO:0016322)2.65647453
158long-term memory (GO:0007616)2.65495616
159axonal fasciculation (GO:0007413)2.64351828
160cellular response to reactive nitrogen species (GO:1902170)2.63752912
161neurotransmitter transport (GO:0006836)2.63617372
162regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.61304439
163endothelial cell chemotaxis (GO:0035767)2.60980885
164response to auditory stimulus (GO:0010996)2.60474633
165peptidyl-tyrosine autophosphorylation (GO:0038083)2.59022228
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.58093865
167response to nitric oxide (GO:0071731)2.56589654
168synaptic transmission, glutamatergic (GO:0035249)2.56310504
169apical protein localization (GO:0045176)2.55520495
170neuromuscular junction development (GO:0007528)2.55235674
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.52958534
172synapse assembly (GO:0007416)2.52869610
173axon ensheathment in central nervous system (GO:0032291)2.51903888
174central nervous system myelination (GO:0022010)2.51903888
175camera-type eye morphogenesis (GO:0048593)2.50728547
176positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50336394
177regulation of neurotransmitter secretion (GO:0046928)2.50044282
178dopamine receptor signaling pathway (GO:0007212)2.48865305
179protein localization to endosome (GO:0036010)2.47851692
180peripheral nervous system axon ensheathment (GO:0032292)2.47836869
181myelination in peripheral nervous system (GO:0022011)2.47836869
182potassium ion import (GO:0010107)2.46432381
183regulation of dendritic spine morphogenesis (GO:0061001)2.46212214
184positive regulation of membrane potential (GO:0045838)2.45927595
185mechanosensory behavior (GO:0007638)2.45039502
186regulation of axon extension involved in axon guidance (GO:0048841)2.44198338
187membrane assembly (GO:0071709)2.42790781
188regulation of vesicle fusion (GO:0031338)2.40984649
189cellular response to monoamine stimulus (GO:0071868)2.40895593
190cellular response to catecholamine stimulus (GO:0071870)2.40895593
191positive regulation of neurotransmitter secretion (GO:0001956)2.40464608
192regulation of neurotransmitter levels (GO:0001505)2.40228095
193innervation (GO:0060384)2.39545632
194negative regulation of catenin import into nucleus (GO:0035414)2.39201764
195positive regulation of dendrite development (GO:1900006)2.39045662
196synapse organization (GO:0050808)2.37852197
197regulation of postsynaptic membrane potential (GO:0060078)2.36716893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.90062977
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.15702818
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.38052280
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.31399332
5EZH2_22144423_ChIP-Seq_EOC_Human3.90520679
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.44901137
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.27833272
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.03830617
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.01754116
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.74389819
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.40462707
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.29152381
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28349819
14* RNF2_27304074_Chip-Seq_ESCs_Mouse2.19354953
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.15412763
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13541692
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10995114
18GATA1_22025678_ChIP-Seq_K562_Human2.06723648
19EED_16625203_ChIP-ChIP_MESCs_Mouse1.97034024
20ZFP281_18757296_ChIP-ChIP_E14_Mouse1.91890104
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.87072063
22WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85978831
23REST_21632747_ChIP-Seq_MESCs_Mouse1.77435915
24FOXA2_19822575_ChIP-Seq_HepG2_Human1.70261250
25CLOCK_20551151_ChIP-Seq_293T_Human1.67018649
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64855452
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64680692
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.64580936
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61266237
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60024385
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58222920
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.58187696
33TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55033940
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.54137093
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50842430
36TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48703543
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.47835872
38RING1B_27294783_Chip-Seq_NPCs_Mouse1.38755709
39* TET1_21490601_ChIP-Seq_MESCs_Mouse1.37920288
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.37828723
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36592324
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35978966
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.35871953
44CTCF_27219007_Chip-Seq_Bcells_Human1.35635882
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.33541960
46BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33093703
47* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31183980
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27886614
49TRIM28_21343339_ChIP-Seq_HEK293_Human1.27783509
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26740548
51KDM2B_26808549_Chip-Seq_DND41_Human1.25559524
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22311843
53* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21446477
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21227443
55CDX2_20551321_ChIP-Seq_CACO-2_Human1.20725257
56RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20673839
57LXR_22292898_ChIP-Seq_THP-1_Human1.19887409
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.19790273
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19531921
60MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17861697
61SMC4_20622854_ChIP-Seq_HELA_Human1.17251109
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16318479
63DROSHA_22980978_ChIP-Seq_HELA_Human1.14761702
64* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14708112
65CTNNB1_20460455_ChIP-Seq_HCT116_Human1.14544684
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13556326
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11964901
68AR_21572438_ChIP-Seq_LNCaP_Human1.11959161
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11460221
70AHR_22903824_ChIP-Seq_MCF-7_Human1.11189459
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10560564
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10448513
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.09605404
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08513877
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.08253836
76HNF4A_19822575_ChIP-Seq_HepG2_Human1.07932936
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07920054
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.07817291
79Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06036693
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.05636223
81ZNF263_19887448_ChIP-Seq_K562_Human1.05413408
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04695491
83GATA4_25053715_ChIP-Seq_YYC3_Human1.03585810
84AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03322761
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.02714490
86GATA2_21666600_ChIP-Seq_HMVEC_Human1.01913992
87ESR1_15608294_ChIP-ChIP_MCF-7_Human1.01841168
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01772687
89SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01405258
90* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00960346
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00524998
92GATA1_19941826_ChIP-Seq_K562_Human1.00240425
93STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.99871864
94KDM2B_26808549_Chip-Seq_K562_Human0.99518059
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98749005
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98721759
97ISL1_27105846_Chip-Seq_CPCs_Mouse0.97769656
98* TCF7_22412390_ChIP-Seq_EML_Mouse0.97659314
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.97057657
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.96914166
101ELK3_25401928_ChIP-Seq_HUVEC_Human0.96493537
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.96185724
103SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.95317557
104SOX2_20726797_ChIP-Seq_SW620_Human0.95043774
105TP53_23651856_ChIP-Seq_MEFs_Mouse0.93228143
106GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92725099
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92347194
108AR_19668381_ChIP-Seq_PC3_Human0.91812867
109SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.88960382
110* RACK7_27058665_Chip-Seq_MCF-7_Human0.87641946
111WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87516259
112GATA2_19941826_ChIP-Seq_K562_Human0.87458718
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86452816
114JARID2_20075857_ChIP-Seq_MESCs_Mouse0.85925142
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85691297
116TET1_21451524_ChIP-Seq_MESCs_Mouse0.84905822
117* RNF2_18974828_ChIP-Seq_MESCs_Mouse0.84409242
118* EZH2_18974828_ChIP-Seq_MESCs_Mouse0.84409242
119DNAJC2_21179169_ChIP-ChIP_NT2_Human0.83908940
120OCT4_19829295_ChIP-Seq_ESCs_Human0.82928337
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.82863616
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.82863616
123* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82467745
124PIAS1_25552417_ChIP-Seq_VCAP_Human0.81942104
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.81708975
126* TBX20_22080862_ChIP-Seq_HEART_Mouse0.81586147
127* TBX20_22328084_ChIP-Seq_HEART_Mouse0.81586147
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.81192740
129KDM2B_26808549_Chip-Seq_SUP-B15_Human0.80907862
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.80147614
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79941376
132SUZ12_27294783_Chip-Seq_ESCs_Mouse0.77849337
133RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76101797
134SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.75758060
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.75187233
136IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74877307
137* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.73914012
138EZH2_27294783_Chip-Seq_ESCs_Mouse0.73611326
139RXR_22108803_ChIP-Seq_LS180_Human0.72648690
140CREB1_26743006_Chip-Seq_LNCaP_Human0.72545937
141RUNX1_27514584_Chip-Seq_MCF-7_Human0.71984564
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.70171601
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.70069948
144NR3C1_23031785_ChIP-Seq_PC12_Mouse0.69218482
145NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.68983947
146BCAT_22108803_ChIP-Seq_LS180_Human0.68934914
147EGR1_19032775_ChIP-ChIP_M12_Human0.68690547
148TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.68671817
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.68301684
150EP300_21415370_ChIP-Seq_HL-1_Mouse0.67368176
151SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67344649
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.67331603
153TP63_23658742_ChIP-Seq_EP156T_Human0.66745991
154NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.66657428
155FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66345677

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.68476252
2MP0005360_urolithiasis6.36385782
3MP0005085_abnormal_gallbladder_physiolo4.75123972
4MP0005365_abnormal_bile_salt4.54752340
5MP0008875_abnormal_xenobiotic_pharmacok4.09821179
6MP0005083_abnormal_biliary_tract3.77367468
7MP0004270_analgesia3.39761478
8MP0003252_abnormal_bile_duct3.15113928
9MP0002138_abnormal_hepatobiliary_system3.07909721
10MP0003635_abnormal_synaptic_transmissio2.91553736
11MP0010329_abnormal_lipoprotein_level2.90135726
12MP0005332_abnormal_amino_acid2.86417764
13MP0005423_abnormal_somatic_nervous2.76907605
14MP0003880_abnormal_central_pattern2.69725851
15MP0003191_abnormal_cellular_cholesterol2.67036082
16MP0009840_abnormal_foam_cell2.46418825
17MP0003195_calcinosis2.46140780
18MP0004019_abnormal_vitamin_homeostasis2.45059046
19MP0002063_abnormal_learning/memory/cond2.44238369
20* MP0004782_abnormal_surfactant_physiolog2.36332093
21MP0002064_seizures2.33774571
22MP0001666_abnormal_nutrient_absorption2.33533388
23MP0003806_abnormal_nucleotide_metabolis2.25233253
24MP0002734_abnormal_mechanical_nocicepti2.19231604
25MP0001958_emphysema2.06413795
26* MP0002118_abnormal_lipid_homeostasis1.99809174
27MP0009745_abnormal_behavioral_response1.99207940
28MP0009643_abnormal_urine_homeostasis1.99012777
29MP0002572_abnormal_emotion/affect_behav1.92912274
30MP0001486_abnormal_startle_reflex1.92277595
31MP0004043_abnormal_pH_regulation1.89491092
32MP0000778_abnormal_nervous_system1.86727333
33MP0002272_abnormal_nervous_system1.82923239
34MP0001968_abnormal_touch/_nociception1.75709975
35MP0005409_darkened_coat_color1.73609362
36MP0003879_abnormal_hair_cell1.72348883
37MP0002733_abnormal_thermal_nociception1.68961082
38MP0000609_abnormal_liver_physiology1.65069244
39MP0005058_abnormal_lysosome_morphology1.64748013
40MP0003329_amyloid_beta_deposits1.63605263
41MP0009046_muscle_twitch1.61737622
42MP0010234_abnormal_vibrissa_follicle1.60258044
43MP0000604_amyloidosis1.57855737
44MP0001502_abnormal_circadian_rhythm1.57616507
45MP0002735_abnormal_chemical_nociception1.57129648
46MP0005584_abnormal_enzyme/coenzyme_acti1.52440846
47MP0001756_abnormal_urination1.49269808
48MP0003634_abnormal_glial_cell1.48936962
49MP0005636_abnormal_mineral_homeostasis1.46047976
50MP0001970_abnormal_pain_threshold1.45358023
51MP0001765_abnormal_ion_homeostasis1.44669260
52MP0005319_abnormal_enzyme/_coenzyme1.44338079
53MP0008569_lethality_at_weaning1.43464733
54MP0002249_abnormal_larynx_morphology1.41130748
55MP0001501_abnormal_sleep_pattern1.40744869
56MP0000566_synostosis1.40332177
57MP0002557_abnormal_social/conspecific_i1.39111795
58MP0004811_abnormal_neuron_physiology1.36843122
59MP0000955_abnormal_spinal_cord1.35269342
60MP0002184_abnormal_innervation1.35122751
61MP0000920_abnormal_myelination1.34832431
62MP0003300_gastrointestinal_ulcer1.28895717
63MP0002882_abnormal_neuron_morphology1.28704137
64MP0003123_paternal_imprinting1.27626284
65MP0008961_abnormal_basal_metabolism1.25422046
66MP0010368_abnormal_lymphatic_system1.24992042
67MP0003868_abnormal_feces_composition1.24899265
68MP0001348_abnormal_lacrimal_gland1.20958882
69MP0002136_abnormal_kidney_physiology1.20058293
70MP0000681_abnormal_thyroid_gland1.19654288
71MP0009780_abnormal_chondrocyte_physiolo1.19171172
72MP0005167_abnormal_blood-brain_barrier1.17265522
73MP0003091_abnormal_cell_migration1.16959878
74MP0000534_abnormal_ureter_morphology1.16186310
75MP0008004_abnormal_stomach_pH1.15220557
76MP0005646_abnormal_pituitary_gland1.14614217
77MP0006276_abnormal_autonomic_nervous1.14239495
78MP0004130_abnormal_muscle_cell1.09016619
79* MP0002066_abnormal_motor_capabilities/c1.08870436
80MP0002067_abnormal_sensory_capabilities1.08697845
81MP0003632_abnormal_nervous_system1.08490418
82MP0002909_abnormal_adrenal_gland1.08169467
83MP0003690_abnormal_glial_cell1.06397647
84MP0002152_abnormal_brain_morphology1.05918231
85MP0003724_increased_susceptibility_to1.03719909
86MP0003283_abnormal_digestive_organ1.01512416
87MP0000462_abnormal_digestive_system1.01335166
88MP0003631_nervous_system_phenotype1.01197861
89MP0001879_abnormal_lymphatic_vessel0.99618727
90MP0001346_abnormal_lacrimal_gland0.99213242
91MP0009764_decreased_sensitivity_to0.98182960
92MP0004858_abnormal_nervous_system0.95741242
93MP0003075_altered_response_to0.93874505
94MP0003705_abnormal_hypodermis_morpholog0.92234895
95MP0002736_abnormal_nociception_after0.92104643
96MP0006138_congestive_heart_failure0.92046987
97MP0000678_abnormal_parathyroid_gland0.90840868
98MP0005535_abnormal_body_temperature0.90477676
99MP0004885_abnormal_endolymph0.89867369
100MP0002876_abnormal_thyroid_physiology0.88284576
101MP0003172_abnormal_lysosome_physiology0.87732983
102* MP0001943_abnormal_respiration0.86720921
103MP0002078_abnormal_glucose_homeostasis0.86555536
104* MP0001177_atelectasis0.86496876
105MP0001984_abnormal_olfaction0.86007368
106MP0005647_abnormal_sex_gland0.85134757
107MP0003122_maternal_imprinting0.85063629
108MP0005076_abnormal_cell_differentiation0.84650400
109MP0003942_abnormal_urinary_system0.84366109
110MP0008995_early_reproductive_senescence0.83882186
111MP0005166_decreased_susceptibility_to0.82432602
112MP0004924_abnormal_behavior0.81517209
113MP0005386_behavior/neurological_phenoty0.81517209
114* MP0009642_abnormal_blood_homeostasis0.81456021
115MP0003566_abnormal_cell_adhesion0.81389857
116MP0002928_abnormal_bile_duct0.80787744
117MP0002168_other_aberrant_phenotype0.80301476
118MP0001764_abnormal_homeostasis0.79718795
119MP0000579_abnormal_nail_morphology0.79323336
120MP0000598_abnormal_liver_morphology0.77368795
121MP0005451_abnormal_body_composition0.77233988
122MP0005623_abnormal_meninges_morphology0.76928020
123MP0000383_abnormal_hair_follicle0.76704140
124MP0002229_neurodegeneration0.74201134
125MP0005084_abnormal_gallbladder_morpholo0.73987226
126MP0003656_abnormal_erythrocyte_physiolo0.73557536
127MP0003861_abnormal_nervous_system0.73423882
128MP0004085_abnormal_heartbeat0.72384377
129MP0005220_abnormal_exocrine_pancreas0.70689077
130MP0010678_abnormal_skin_adnexa0.70370084
131MP0002638_abnormal_pupillary_reflex0.70019229
132MP0001299_abnormal_eye_distance/0.69307896
133MP0000751_myopathy0.68477062
134MP0003638_abnormal_response/metabolism_0.68051278
135MP0001849_ear_inflammation0.67914837
136MP0005408_hypopigmentation0.67371136
137MP0008469_abnormal_protein_level0.66436318
138MP0004272_abnormal_basement_membrane0.65925564
139MP0005334_abnormal_fat_pad0.65770896
140MP0005666_abnormal_adipose_tissue0.65744746
141MP0000230_abnormal_systemic_arterial0.65557131
142MP0001963_abnormal_hearing_physiology0.65475076
143MP0000538_abnormal_urinary_bladder0.63785993
144MP0000026_abnormal_inner_ear0.63224524
145MP0002796_impaired_skin_barrier0.62563768
146MP0004742_abnormal_vestibular_system0.62424873
147MP0008874_decreased_physiological_sensi0.61940505
148MP0002896_abnormal_bone_mineralization0.61828120
149* MP0002295_abnormal_pulmonary_circulatio0.61764603
150MP0005670_abnormal_white_adipose0.60605280
151* MP0002133_abnormal_respiratory_system0.59711577
152* MP0005388_respiratory_system_phenotype0.59711577
153MP0002752_abnormal_somatic_nervous0.58934574
154MP0003186_abnormal_redox_activity0.58468142
155MP0003953_abnormal_hormone_level0.58398760
156MP0002254_reproductive_system_inflammat0.58130629
157MP0002971_abnormal_brown_adipose0.55715715
158MP0004264_abnormal_extraembryonic_tissu0.53726385
159MP0000639_abnormal_adrenal_gland0.53178807
160MP0002135_abnormal_kidney_morphology0.52746539
161MP0003633_abnormal_nervous_system0.50871626
162MP0005448_abnormal_energy_balance0.49556439
163MP0004859_abnormal_synaptic_plasticity0.49373432
164MP0001664_abnormal_digestion0.49060811
165MP0009765_abnormal_xenobiotic_induced0.48464297
166MP0004185_abnormal_adipocyte_glucose0.48157353
167MP0009763_increased_sensitivity_to0.47095065
168MP0002822_catalepsy0.46706805
169MP0001944_abnormal_pancreas_morphology0.46204885
170MP0003303_peritoneal_inflammation0.44512539
171MP0001440_abnormal_grooming_behavior0.43996027
172MP0005375_adipose_tissue_phenotype0.43297775
173MP0005595_abnormal_vascular_smooth0.42879638
174MP0000537_abnormal_urethra_morphology0.42325046
175MP0005464_abnormal_platelet_physiology0.40869686

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.73306986
2Deep venous thrombosis (HP:0002625)5.07045089
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.81530854
4Intrahepatic cholestasis (HP:0001406)4.53064545
5Xanthomatosis (HP:0000991)4.38490178
6Myokymia (HP:0002411)4.34113435
7Hyperactive renin-angiotensin system (HP:0000841)4.32477080
8Abnormality of monocarboxylic acid metabolism (HP:0010996)4.13431537
9Abnormality of glutamine family amino acid metabolism (HP:0010902)3.97068008
10Abnormality of purine metabolism (HP:0004352)3.85065212
11Ketosis (HP:0001946)3.83194611
12Obstructive sleep apnea (HP:0002870)3.80353078
13Hyperglycinuria (HP:0003108)3.77767633
14Complement deficiency (HP:0004431)3.72644725
15Prolonged partial thromboplastin time (HP:0003645)3.53428581
16Hyperlipoproteinemia (HP:0010980)3.47223078
17Ketoacidosis (HP:0001993)3.43260084
18Abnormality of glycine metabolism (HP:0010895)3.42597633
19Abnormality of serine family amino acid metabolism (HP:0010894)3.42597633
20Ankle clonus (HP:0011448)3.39198639
21Increased purine levels (HP:0004368)3.35548054
22Hyperuricemia (HP:0002149)3.35548054
23Action tremor (HP:0002345)3.31948261
24Hyperglycinemia (HP:0002154)3.30063331
25Hypokalemic alkalosis (HP:0001949)3.27576382
26Focal motor seizures (HP:0011153)3.26168669
27Hyperammonemia (HP:0001987)3.26045784
28Joint hemorrhage (HP:0005261)3.24670238
29Abnormality of the fingertips (HP:0001211)3.17545494
30Tubulointerstitial fibrosis (HP:0005576)3.12429779
31Abnormality of nucleobase metabolism (HP:0010932)3.11837802
32Hypobetalipoproteinemia (HP:0003563)3.11726952
33Abnormality of the common coagulation pathway (HP:0010990)3.10146380
34Abnormality of chloride homeostasis (HP:0011422)3.06510597
35Renal salt wasting (HP:0000127)3.03311899
36Cerebral aneurysm (HP:0004944)3.00018943
37Hyperacusis (HP:0010780)2.99903477
38Focal seizures (HP:0007359)2.99485234
39Abnormality of sulfur amino acid metabolism (HP:0004339)2.96521862
40Neurofibrillary tangles (HP:0002185)2.92708244
41Alkalosis (HP:0001948)2.92189504
42Hypoglycemic coma (HP:0001325)2.89855651
43Delayed CNS myelination (HP:0002188)2.89083660
44Increased circulating renin level (HP:0000848)2.88814518
45Epidermoid cyst (HP:0200040)2.84243052
46* Interstitial pulmonary disease (HP:0006530)2.83639028
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76475865
48Bronchomalacia (HP:0002780)2.69154965
49Vascular calcification (HP:0004934)2.67717609
50Aplasia involving bones of the extremities (HP:0009825)2.66782253
51Aplasia involving bones of the upper limbs (HP:0009823)2.66782253
52Aplasia of the phalanges of the hand (HP:0009802)2.66782253
53Cerebral inclusion bodies (HP:0100314)2.63560758
54Abnormality of renal excretion (HP:0011036)2.61523189
55Proximal tubulopathy (HP:0000114)2.59829608
56Abnormality of fatty-acid metabolism (HP:0004359)2.59156030
57Fat malabsorption (HP:0002630)2.59017631
58Sensorimotor neuropathy (HP:0007141)2.58129465
59Abnormality of the intrinsic pathway (HP:0010989)2.54846168
60Abnormality of complement system (HP:0005339)2.54510150
61Rapidly progressive (HP:0003678)2.53348355
62Hepatocellular carcinoma (HP:0001402)2.52757193
63Abnormality of renin-angiotensin system (HP:0000847)2.52723097
64Insomnia (HP:0100785)2.51621256
65Metabolic alkalosis (HP:0200114)2.51018901
66Epileptic encephalopathy (HP:0200134)2.50883244
67Spastic gait (HP:0002064)2.50185419
68Conjugated hyperbilirubinemia (HP:0002908)2.49318116
69Hypolipoproteinemia (HP:0010981)2.47152011
70Annular pancreas (HP:0001734)2.46848196
71Growth hormone excess (HP:0000845)2.44552865
72* Tachypnea (HP:0002789)2.44063912
73Hyperaldosteronism (HP:0000859)2.39156187
74Esophageal varix (HP:0002040)2.38865156
75Malnutrition (HP:0004395)2.37483653
76Hypoalphalipoproteinemia (HP:0003233)2.37392943
77Febrile seizures (HP:0002373)2.36632307
78Cardiovascular calcification (HP:0011915)2.35330952
79Metabolic acidosis (HP:0001942)2.34614774
80Abnormal urine output (HP:0012590)2.33954757
81Hypomagnesemia (HP:0002917)2.32852009
82Generalized aminoaciduria (HP:0002909)2.32318210
83Macroorchidism (HP:0000053)2.30962657
84Hydroxyprolinuria (HP:0003080)2.30589291
85Abnormality of proline metabolism (HP:0010907)2.30589291
86Truncal ataxia (HP:0002078)2.30344952
87Polycythemia (HP:0001901)2.29915417
88Intention tremor (HP:0002080)2.29794253
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.29633594
90Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.29491906
91Neuronal loss in central nervous system (HP:0002529)2.28786188
92Lower limb amyotrophy (HP:0007210)2.24920745
93Akinesia (HP:0002304)2.23359638
94Glomerulosclerosis (HP:0000096)2.20395471
95Shallow orbits (HP:0000586)2.19124091
96Atonic seizures (HP:0010819)2.17585690
97Nephrolithiasis (HP:0000787)2.16019595
98Depression (HP:0000716)2.14907135
99Hammertoe (HP:0001765)2.14844773
100Hyperbilirubinemia (HP:0002904)2.12738545
101Hypercholesterolemia (HP:0003124)2.11963937
102Spastic diplegia (HP:0001264)2.11597075
103Potter facies (HP:0002009)2.09858233
104Facial shape deformation (HP:0011334)2.09858233
105Polyuria (HP:0000103)2.09607502
106Pointed chin (HP:0000307)2.08876732
107Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08459738
108Turricephaly (HP:0000262)2.08458444
109Urinary bladder sphincter dysfunction (HP:0002839)2.08263419
110Hypercortisolism (HP:0001578)2.07044836
111Mitral stenosis (HP:0001718)2.06049515
112Visceral angiomatosis (HP:0100761)2.05649815
113Late onset (HP:0003584)2.05247330
114Diplopia (HP:0000651)2.04095390
115Abnormality of binocular vision (HP:0011514)2.04095390
116Systemic lupus erythematosus (HP:0002725)2.03786449
117Rickets (HP:0002748)2.03634284
118Hypoglycemic seizures (HP:0002173)2.03221709
119Ulnar claw (HP:0001178)2.02800523
120Irritability (HP:0000737)2.02401106
121Abnormal eating behavior (HP:0100738)2.01546653
122Neonatal onset (HP:0003623)2.01086769
123Lymphangioma (HP:0100764)1.99323975
124Sleep apnea (HP:0010535)1.98845391
125Supranuclear gaze palsy (HP:0000605)1.98063945
126Germ cell neoplasia (HP:0100728)1.97688212
127Myocardial infarction (HP:0001658)1.97197861
128Generalized tonic-clonic seizures (HP:0002069)1.97003296
129Glycosuria (HP:0003076)1.96135056
130Abnormality of urine glucose concentration (HP:0011016)1.96135056
131Skin nodule (HP:0200036)1.96027336
132Dysmetria (HP:0001310)1.95787930
133Abnormality of magnesium homeostasis (HP:0004921)1.95272036
134Tetany (HP:0001281)1.94267295
135Overriding aorta (HP:0002623)1.94092008
136Hemangiomatosis (HP:0007461)1.92203373
137Stereotypic behavior (HP:0000733)1.91603083
138Apathy (HP:0000741)1.91568538
139Torticollis (HP:0000473)1.91176368
140Anxiety (HP:0000739)1.91138136
141Abnormality of the lower motor neuron (HP:0002366)1.90977330
142Mucopolysacchariduria (HP:0008155)1.89390883
143Urinary glycosaminoglycan excretion (HP:0003541)1.89390883
144Abnormal enzyme/coenzyme activity (HP:0012379)1.88484590
145Hyperkalemia (HP:0002153)1.87133362
146Abnormality of methionine metabolism (HP:0010901)1.86757798
147Vomiting (HP:0002013)1.86034844
148Amyloidosis (HP:0011034)1.85957780
149Broad face (HP:0000283)1.85952996
150Glomerulonephritis (HP:0000099)1.85453990
151Megalencephaly (HP:0001355)1.84853858
152Lower limb muscle weakness (HP:0007340)1.83358723
153Precocious puberty (HP:0000826)1.83329841
154Dysmetric saccades (HP:0000641)1.81883802
155Elfin facies (HP:0004428)1.81418941
156Spinal canal stenosis (HP:0003416)1.81354739
157Peripheral hypomyelination (HP:0007182)1.80798004
158Poor eye contact (HP:0000817)1.80025549
159Postural instability (HP:0002172)1.77861810
160Foot dorsiflexor weakness (HP:0009027)1.76624984
161Neoplasm of the heart (HP:0100544)1.76236490
162Decreased motor nerve conduction velocity (HP:0003431)1.75934388
163Lower limb asymmetry (HP:0100559)1.73606265
164Hemiplegia (HP:0002301)1.69729143
165Epileptiform EEG discharges (HP:0011182)1.69441443
166Diminished motivation (HP:0000745)1.68698159
167Papilledema (HP:0001085)1.68537797
168Distal upper limb amyotrophy (HP:0007149)1.68516717
169Upper limb amyotrophy (HP:0009129)1.68516717
170Shawl scrotum (HP:0000049)1.68449820
171Onion bulb formation (HP:0003383)1.67850067
172Urinary urgency (HP:0000012)1.66514953
173Hyperparathyroidism (HP:0000843)1.66061946
174Renovascular hypertension (HP:0100817)1.65714168
175Limb dystonia (HP:0002451)1.65518261
176Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65432463
177Slow progression (HP:0003677)1.65264937
178Abnormality of the corticospinal tract (HP:0002492)1.63870578
179Incomplete penetrance (HP:0003829)1.63562836
180Arterial tortuosity (HP:0005116)1.61213079
181Distal sensory impairment (HP:0002936)1.61018709
182J-shaped sella turcica (HP:0002680)1.59978491
183Impaired social interactions (HP:0000735)1.59348669
184Abnormal social behavior (HP:0012433)1.59348669
185Termporal pattern (HP:0011008)1.58769914
186Insidious onset (HP:0003587)1.58769914
187Long toe (HP:0010511)1.57940871
188Abnormality of the periventricular white matter (HP:0002518)1.57351336
189Mutism (HP:0002300)1.57164453
190Nuclear cataract (HP:0100018)1.57139696
191Hyperventilation (HP:0002883)1.56797399
192Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.56712719

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK42.98001179
2ERN12.82108154
3SIK12.80148628
4BCKDK2.76054597
5FGFR42.75025351
6TRIB32.58825197
7FGFR22.58761825
8DAPK22.49692995
9PRKD32.29689378
10WNK32.22239867
11OXSR12.16511093
12TAOK32.15039243
13EEF2K1.98232378
14MST1R1.93741401
15MAP3K91.86639726
16RIPK11.82280564
17INSRR1.80958384
18CASK1.79182799
19LATS21.68164864
20MAP3K21.66772257
21CAMK1G1.64785489
22EPHB11.62537872
23PTK61.61470863
24UHMK11.60730284
25PRPF4B1.57491705
26CAMK1D1.52593406
27TIE11.51627889
28MAP2K41.49470838
29NTRK11.39047019
30PKN21.37090743
31TGFBR21.34958803
32LMTK21.33278091
33STK391.28457363
34MAP3K71.27751023
35MARK11.26024368
36FRK1.21096199
37KSR21.19260911
38SGK31.16097415
39TYRO31.13829229
40LRRK21.12369559
41STK241.12252667
42NEK61.11982216
43CAMK2B1.08661452
44RET1.07190204
45SGK4941.06322734
46SGK2231.06322734
47MAPK151.05120261
48TESK11.03519235
49FER1.02397323
50PTK20.95667252
51JAK10.93245964
52SMG10.91396685
53GSK3A0.91014372
54STK380.90354282
55PDPK10.89166083
56MTOR0.88092830
57JAK20.87299424
58SGK20.86589974
59ZAP700.86134086
60PDGFRB0.85977882
61PRKCH0.84265848
62CDC42BPA0.82794620
63EPHA20.82586593
64FGFR30.81301384
65CAMKK10.80689761
66PRKCZ0.80536278
67PDGFRA0.80326893
68EPHA40.79234543
69CDK120.77945728
70MAP3K10.77497951
71ERBB20.76950524
72MAPK100.76769560
73LATS10.73626477
74ARAF0.72705519
75MAP3K40.72150680
76NTRK30.70597246
77CDK150.70527935
78GRK50.70178568
79CAMK2G0.66242458
80CDK180.65979042
81MET0.65364635
82TAOK10.64635208
83ALK0.64345782
84MINK10.63062009
85CDK11A0.60887873
86ROCK20.60543629
87HIPK20.60313486
88CAMK10.59879240
89PHKG20.59721392
90PHKG10.59721392
91MAP2K10.59698831
92TYK20.59266198
93RPS6KA20.58628346
94MARK20.57468688
95EPHA30.57314376
96PDK10.57084426
97CDK140.56427561
98PRKAA20.55849126
99ICK0.55067261
100PRKAA10.54725387
101PAK30.54602664
102SIK20.54082817
103DYRK1A0.53966179
104MAP3K30.53487830
105CAMK2A0.53156735
106WNK10.52966498
107MAPK110.51573463
108EGFR0.49730986
109ERBB40.49685227
110PKN10.48433606
111PRKACG0.47217627
112DYRK1B0.46892162
113MAP3K60.46815428
114GRK60.46209311
115MAP3K130.45714632
116KSR10.45284731
117EPHB20.45259010
118ROCK10.45123297
119STK110.44752103
120PRKD10.44638579
121PAK60.44449600
122PIK3CG0.44370045
123CAMK40.44349577
124PRKCQ0.43417258
125MAPK120.43256761
126BMX0.43094340
127CDK50.43010421
128MAPK80.42968634
129MAPK130.42942677
130DAPK10.42925133
131PRKCG0.42397192
132CDK60.42395117
133NTRK20.42287425
134RPS6KA30.41970203
135ABL20.41754303
136SCYL20.41715102
137DMPK0.41526771
138SGK10.41490005
139MAP2K20.40853984
140CSNK1G20.40267962
141PRKD20.40208479
142PINK10.39919229

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.28025309
2Nitrogen metabolism_Homo sapiens_hsa009103.27210653
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.17516115
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.66061149
5Tryptophan metabolism_Homo sapiens_hsa003802.48604502
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.46383200
7Fatty acid degradation_Homo sapiens_hsa000712.45913961
8Butanoate metabolism_Homo sapiens_hsa006502.44503982
9Arginine biosynthesis_Homo sapiens_hsa002202.40882104
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37467633
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34038601
12Nicotine addiction_Homo sapiens_hsa050332.24481098
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.13625989
14Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.09794016
15Long-term potentiation_Homo sapiens_hsa047202.04748397
16Propanoate metabolism_Homo sapiens_hsa006401.97488633
17Glutamatergic synapse_Homo sapiens_hsa047241.95251604
18Complement and coagulation cascades_Homo sapiens_hsa046101.95119536
19Peroxisome_Homo sapiens_hsa041461.93240108
20Fatty acid metabolism_Homo sapiens_hsa012121.92889979
21Circadian entrainment_Homo sapiens_hsa047131.92720437
22Bile secretion_Homo sapiens_hsa049761.92212236
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87953761
24PPAR signaling pathway_Homo sapiens_hsa033201.78914119
25Amphetamine addiction_Homo sapiens_hsa050311.73523547
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.69155681
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.67987330
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.63936554
29Histidine metabolism_Homo sapiens_hsa003401.63228503
30beta-Alanine metabolism_Homo sapiens_hsa004101.61754835
31Morphine addiction_Homo sapiens_hsa050321.60550247
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55846712
33Cocaine addiction_Homo sapiens_hsa050301.54459268
34Dopaminergic synapse_Homo sapiens_hsa047281.47563611
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44801078
36Cholinergic synapse_Homo sapiens_hsa047251.44046714
37Sulfur metabolism_Homo sapiens_hsa009201.40941987
38Estrogen signaling pathway_Homo sapiens_hsa049151.40002236
39VEGF signaling pathway_Homo sapiens_hsa043701.36746831
40Axon guidance_Homo sapiens_hsa043601.36620384
41Pyruvate metabolism_Homo sapiens_hsa006201.36546993
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36318439
43GnRH signaling pathway_Homo sapiens_hsa049121.31699175
44Chemical carcinogenesis_Homo sapiens_hsa052041.30965360
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28316554
46Oxytocin signaling pathway_Homo sapiens_hsa049211.28068213
47Staphylococcus aureus infection_Homo sapiens_hsa051501.27373046
48Caffeine metabolism_Homo sapiens_hsa002321.26877809
49ErbB signaling pathway_Homo sapiens_hsa040121.26065491
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.26004849
51Glioma_Homo sapiens_hsa052141.22021629
52Notch signaling pathway_Homo sapiens_hsa043301.21017355
53Long-term depression_Homo sapiens_hsa047301.20107744
54Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19945840
55Renal cell carcinoma_Homo sapiens_hsa052111.17578958
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.17393598
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.16540948
58Gap junction_Homo sapiens_hsa045401.14832504
59Selenocompound metabolism_Homo sapiens_hsa004501.14713539
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14623904
61cAMP signaling pathway_Homo sapiens_hsa040241.14236460
62Starch and sucrose metabolism_Homo sapiens_hsa005001.14087044
63Maturity onset diabetes of the young_Homo sapiens_hsa049501.11864947
64* ABC transporters_Homo sapiens_hsa020101.10647828
65Phenylalanine metabolism_Homo sapiens_hsa003601.09083914
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07721708
67Dilated cardiomyopathy_Homo sapiens_hsa054141.07257847
68Retinol metabolism_Homo sapiens_hsa008301.06400597
69Choline metabolism in cancer_Homo sapiens_hsa052311.06229824
70Melanogenesis_Homo sapiens_hsa049161.04895274
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04406420
72Endometrial cancer_Homo sapiens_hsa052131.03567043
73mTOR signaling pathway_Homo sapiens_hsa041501.03350907
74Neurotrophin signaling pathway_Homo sapiens_hsa047221.02179520
75Vitamin B6 metabolism_Homo sapiens_hsa007501.01830528
76ECM-receptor interaction_Homo sapiens_hsa045121.01820015
77Fatty acid elongation_Homo sapiens_hsa000621.01365885
78Tight junction_Homo sapiens_hsa045301.01273520
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99656031
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99569698
81Vitamin digestion and absorption_Homo sapiens_hsa049770.98626222
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.97111775
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94316870
84Adherens junction_Homo sapiens_hsa045200.93535325
85Fatty acid biosynthesis_Homo sapiens_hsa000610.93100037
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92258038
87Glycerolipid metabolism_Homo sapiens_hsa005610.92060494
88Rap1 signaling pathway_Homo sapiens_hsa040150.91883951
89Lysine degradation_Homo sapiens_hsa003100.89905367
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.89415781
91Focal adhesion_Homo sapiens_hsa045100.89200575
92Taste transduction_Homo sapiens_hsa047420.88705511
93Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88450662
94Carbon metabolism_Homo sapiens_hsa012000.86863471
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86475048
96Calcium signaling pathway_Homo sapiens_hsa040200.85400211
97Vibrio cholerae infection_Homo sapiens_hsa051100.84792981
98Inositol phosphate metabolism_Homo sapiens_hsa005620.84226736
99Tyrosine metabolism_Homo sapiens_hsa003500.83967008
100Serotonergic synapse_Homo sapiens_hsa047260.83164106
101Fat digestion and absorption_Homo sapiens_hsa049750.83099493
102Endocytosis_Homo sapiens_hsa041440.81643390
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81065668
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79096903
105Arginine and proline metabolism_Homo sapiens_hsa003300.76143244
106Ovarian steroidogenesis_Homo sapiens_hsa049130.74882760
107MAPK signaling pathway_Homo sapiens_hsa040100.74023704
108Hippo signaling pathway_Homo sapiens_hsa043900.73772955
109Mineral absorption_Homo sapiens_hsa049780.72520365
110Ras signaling pathway_Homo sapiens_hsa040140.72412888
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71482916
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.71354237
113Chronic myeloid leukemia_Homo sapiens_hsa052200.71288639
114Prolactin signaling pathway_Homo sapiens_hsa049170.71256087
115Steroid biosynthesis_Homo sapiens_hsa001000.69581309
116Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.68682023
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67557944
118Lysosome_Homo sapiens_hsa041420.64384539
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.60990297
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.59947267
121Circadian rhythm_Homo sapiens_hsa047100.58926395
122Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57249676
123Biosynthesis of amino acids_Homo sapiens_hsa012300.57139702
124Insulin resistance_Homo sapiens_hsa049310.57040027
125Colorectal cancer_Homo sapiens_hsa052100.56860585
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56028087
127Non-small cell lung cancer_Homo sapiens_hsa052230.55860039
128Proteoglycans in cancer_Homo sapiens_hsa052050.55280684
129Collecting duct acid secretion_Homo sapiens_hsa049660.55180263
130Adipocytokine signaling pathway_Homo sapiens_hsa049200.54027970
131Glutathione metabolism_Homo sapiens_hsa004800.51600024
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48954246
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48743315
134Oocyte meiosis_Homo sapiens_hsa041140.48701016
135Folate biosynthesis_Homo sapiens_hsa007900.48103655
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47928240
137Wnt signaling pathway_Homo sapiens_hsa043100.47428894
138Pancreatic cancer_Homo sapiens_hsa052120.47368671
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47268824
140Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46506072
141Thyroid hormone synthesis_Homo sapiens_hsa049180.46447976
142Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46027116
143Sulfur relay system_Homo sapiens_hsa041220.42802484
144Gastric acid secretion_Homo sapiens_hsa049710.40166561
145Prion diseases_Homo sapiens_hsa050200.36031076
146Type II diabetes mellitus_Homo sapiens_hsa049300.34263232
147Synaptic vesicle cycle_Homo sapiens_hsa047210.33011355
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30899193
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.30659381
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.30420863
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28860348
152AMPK signaling pathway_Homo sapiens_hsa041520.28205668
153Glucagon signaling pathway_Homo sapiens_hsa049220.26551726
154Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24892703
155Salivary secretion_Homo sapiens_hsa049700.23665456
156Pentose phosphate pathway_Homo sapiens_hsa000300.23097033
157Insulin signaling pathway_Homo sapiens_hsa049100.22388096
158Protein digestion and absorption_Homo sapiens_hsa049740.22358496
159Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21728758
160Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.21445953
161Renin-angiotensin system_Homo sapiens_hsa046140.21079821
162Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20888121
163Insulin secretion_Homo sapiens_hsa049110.20065015
164Metabolic pathways_Homo sapiens_hsa011000.17761981
165Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17155696
166GABAergic synapse_Homo sapiens_hsa047270.17130561
167Other glycan degradation_Homo sapiens_hsa005110.13658921
168Fructose and mannose metabolism_Homo sapiens_hsa000510.13275746
169Renin secretion_Homo sapiens_hsa049240.12623139
170Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12456669
171Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10670737
172Pancreatic secretion_Homo sapiens_hsa049720.09521585
173Dorso-ventral axis formation_Homo sapiens_hsa043200.09128090

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