ABCA4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essental molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease, a form of juvenile-onset macular degeneration. Mutations in this gene are also associated with retinitis pigmentosa-19, cone-rod dystrophy type 3, early-onset severe retinal dystrophy, fundus flavimaculatus, and macular degeneration age-related 2. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* detection of visible light (GO:0009584)9.87825034
2* detection of light stimulus (GO:0009583)9.83227790
3GMP metabolic process (GO:0046037)9.42672316
4positive regulation of guanylate cyclase activity (GO:0031284)8.67882164
5* visual perception (GO:0007601)8.67526686
6* sensory perception of light stimulus (GO:0050953)8.57505841
7regulation of guanylate cyclase activity (GO:0031282)7.83357712
8cellular response to light stimulus (GO:0071482)7.47599466
9* detection of external stimulus (GO:0009581)6.86505482
10photoreceptor cell differentiation (GO:0046530)6.81387121
11eye photoreceptor cell differentiation (GO:0001754)6.81387121
12* detection of abiotic stimulus (GO:0009582)6.73148188
13retina development in camera-type eye (GO:0060041)6.47739030
14polyketide metabolic process (GO:0030638)6.03444352
15doxorubicin metabolic process (GO:0044598)6.03444352
16daunorubicin metabolic process (GO:0044597)6.03444352
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.79651877
18cellular response to electrical stimulus (GO:0071257)5.75234091
19aminoglycoside antibiotic metabolic process (GO:0030647)5.72080070
20regulation of cGMP metabolic process (GO:0030823)5.65578973
21positive regulation of cGMP biosynthetic process (GO:0030828)5.12171036
22cellular response to radiation (GO:0071478)4.85995529
23regulation of cGMP biosynthetic process (GO:0030826)4.80278933
24adaptation of signaling pathway (GO:0023058)4.71681907
25detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)4.69877267
26nonmotile primary cilium assembly (GO:0035058)4.65699110
27positive regulation of cGMP metabolic process (GO:0030825)4.51632762
28retinal metabolic process (GO:0042574)4.51459902
29cell morphogenesis involved in neuron differentiation (GO:0048667)4.42740511
30receptor guanylyl cyclase signaling pathway (GO:0007168)4.42437324
31estrogen biosynthetic process (GO:0006703)4.35454744
32surfactant homeostasis (GO:0043129)4.31368948
33regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.26223808
34regulation of clathrin-mediated endocytosis (GO:2000369)4.22989384
35* sensory perception (GO:0007600)4.07253536
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.06196530
37endothelium development (GO:0003158)4.05042958
38retina layer formation (GO:0010842)4.03151783
39bundle of His cell to Purkinje myocyte communication (GO:0086069)4.01795141
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87674646
41regulation of voltage-gated calcium channel activity (GO:1901385)3.84401065
42* response to light stimulus (GO:0009416)3.78514981
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78405124
44chemical homeostasis within a tissue (GO:0048875)3.63627791
45neuron development (GO:0048666)3.57859135
46protein prenylation (GO:0018342)3.43923295
47prenylation (GO:0097354)3.43923295
48protein localization to synapse (GO:0035418)3.38435781
49semaphorin-plexin signaling pathway (GO:0071526)3.33308654
50behavioral response to ethanol (GO:0048149)3.31021084
51membrane hyperpolarization (GO:0060081)3.30762432
52CDP-diacylglycerol biosynthetic process (GO:0016024)3.26184951
53paraxial mesoderm development (GO:0048339)3.24736489
54heme transport (GO:0015886)3.23278245
55retina homeostasis (GO:0001895)3.23213914
56response to pheromone (GO:0019236)3.20800356
57cilium or flagellum-dependent cell motility (GO:0001539)3.20734897
58primary alcohol catabolic process (GO:0034310)3.16311744
59negative regulation of receptor-mediated endocytosis (GO:0048261)3.15415215
60positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.15080983
61synaptic vesicle docking involved in exocytosis (GO:0016081)3.14716351
62peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.11856748
63positive regulation of hormone biosynthetic process (GO:0046886)3.11246025
64negative regulation of keratinocyte proliferation (GO:0010839)3.08860303
65bone remodeling (GO:0046849)3.08024672
66positive regulation of neurotransmitter transport (GO:0051590)3.07447319
67positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.05596119
68fat-soluble vitamin metabolic process (GO:0006775)3.01339718
69hippo signaling (GO:0035329)3.00412804
70piRNA metabolic process (GO:0034587)2.98826896
71positive regulation of sodium ion transmembrane transport (GO:1902307)2.98690507
72CDP-diacylglycerol metabolic process (GO:0046341)2.94150137
73short-term memory (GO:0007614)2.91409114
74chemosensory behavior (GO:0007635)2.90952251
75response to histamine (GO:0034776)2.89536135
76intestinal cholesterol absorption (GO:0030299)2.89399569
77regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.87588736
78regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.87588736
79synaptic vesicle maturation (GO:0016188)2.85654616
80quaternary ammonium group transport (GO:0015697)2.85387971
81axoneme assembly (GO:0035082)2.84480388
82glycoside metabolic process (GO:0016137)2.83176763
83retinol metabolic process (GO:0042572)2.82124315
84gap junction assembly (GO:0016264)2.81305008
85zinc ion transmembrane transport (GO:0071577)2.80517308
86negative regulation of complement activation (GO:0045916)2.79048766
87positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.78046216
88* retinoid metabolic process (GO:0001523)2.76892225
89ventricular trabecula myocardium morphogenesis (GO:0003222)2.74380248
90regulation of penile erection (GO:0060405)2.72133001
91cellular potassium ion homeostasis (GO:0030007)2.71055148
92desmosome organization (GO:0002934)2.70654916
93embryonic foregut morphogenesis (GO:0048617)2.68000361
94neuron remodeling (GO:0016322)2.67498619
95retina vasculature morphogenesis in camera-type eye (GO:0061299)2.66964835
96post-embryonic morphogenesis (GO:0009886)2.65038968
97negative regulation of protein activation cascade (GO:2000258)2.63165657
98polyol transport (GO:0015791)2.63109656
99regulation of hippo signaling (GO:0035330)2.62825521
100cell differentiation involved in metanephros development (GO:0072202)2.62379796
101primary alcohol metabolic process (GO:0034308)2.61852097
102notochord development (GO:0030903)2.60903733
103detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.59647068
104* response to radiation (GO:0009314)2.58959878
105lymphangiogenesis (GO:0001946)2.58750265
106keratan sulfate catabolic process (GO:0042340)2.57079818
107* diterpenoid metabolic process (GO:0016101)2.56461255
108regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.56206289
109positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.55708597
110biotin metabolic process (GO:0006768)2.54232140
111cell-cell junction maintenance (GO:0045217)2.53779966
112vascular endothelial growth factor signaling pathway (GO:0038084)2.52756827
113substrate adhesion-dependent cell spreading (GO:0034446)2.52182084
114sodium ion export (GO:0071436)2.51656969
115embryonic heart tube development (GO:0035050)2.50105854
116vitamin A metabolic process (GO:0006776)2.50052123
117positive regulation of hormone metabolic process (GO:0032352)2.49655806
118cellular response to abiotic stimulus (GO:0071214)2.49213304
119detection of chemical stimulus involved in sensory perception (GO:0050907)2.48722880
120arachidonic acid secretion (GO:0050482)2.47426531
121icosanoid secretion (GO:0032309)2.47426531
122lung-associated mesenchyme development (GO:0060484)2.47373512
123dopamine receptor signaling pathway (GO:0007212)2.46878342
124* isoprenoid metabolic process (GO:0006720)2.46513550
125endothelial cell differentiation (GO:0045446)2.46285247
126negative regulation of cation channel activity (GO:2001258)2.46138544
127righting reflex (GO:0060013)2.45893121
128negative regulation of calcium ion transmembrane transport (GO:1903170)2.43983494
129negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.43983494
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.42572009
131smooth muscle tissue development (GO:0048745)2.39616207
132potassium ion homeostasis (GO:0055075)2.39353737
133apical protein localization (GO:0045176)2.37995089
134genitalia morphogenesis (GO:0035112)2.36527630
135positive regulation of ERBB signaling pathway (GO:1901186)2.36367116
136mitochondrion transport along microtubule (GO:0047497)2.36295499
137establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.36295499
138hair cell differentiation (GO:0035315)2.35806360
139negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.35317332
140negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.35137821
141synaptonemal complex assembly (GO:0007130)2.35086206
142cell junction maintenance (GO:0034331)2.33166586
143regulation of transforming growth factor beta2 production (GO:0032909)2.32388375
144* terpenoid metabolic process (GO:0006721)2.32151241
145lymph vessel development (GO:0001945)2.30855449
146peripheral nervous system development (GO:0007422)2.30273588
147lipoprotein transport (GO:0042953)2.29499587
148non-canonical Wnt signaling pathway (GO:0035567)2.28736775
149regulation of synaptic vesicle exocytosis (GO:2000300)2.28296855
150tight junction assembly (GO:0070830)2.28136091
151modified amino acid transport (GO:0072337)2.27509750
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.25407195
153asymmetric protein localization (GO:0008105)2.25267776
154cell-cell junction assembly (GO:0007043)2.24934578
155trivalent inorganic anion homeostasis (GO:0072506)2.24597895
156phosphate ion homeostasis (GO:0055062)2.24597895
157response to nitrosative stress (GO:0051409)2.24005972
158embryonic retina morphogenesis in camera-type eye (GO:0060059)2.23200373
159drug transmembrane transport (GO:0006855)2.22766384
160facial nerve structural organization (GO:0021612)2.22353160
161regulation of rhodopsin mediated signaling pathway (GO:0022400)17.8540333
162rhodopsin mediated signaling pathway (GO:0016056)17.5505067
163retinal cone cell development (GO:0046549)14.8322223
164photoreceptor cell development (GO:0042461)11.9394772
165detection of light stimulus involved in sensory perception (GO:0050962)11.6772785
166detection of light stimulus involved in visual perception (GO:0050908)11.6772785
167eye photoreceptor cell development (GO:0042462)11.3360495
168* photoreceptor cell maintenance (GO:0045494)11.1102809
169protein-chromophore linkage (GO:0018298)10.4556013
170* phototransduction (GO:0007602)10.3430799
171* phototransduction, visible light (GO:0007603)10.2995061
172retinal rod cell development (GO:0046548)10.2772306

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71605710
2CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse3.66851344
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.52762073
4GBX2_23144817_ChIP-Seq_PC3_Human3.17554822
5DROSHA_22980978_ChIP-Seq_HELA_Human2.54398027
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44055803
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.36693634
8* AHR_22903824_ChIP-Seq_MCF-7_Human2.21949613
9SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.19760094
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.16841765
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.12762964
12DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.08192673
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03119766
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.00813037
15AR_21572438_ChIP-Seq_LNCaP_Human1.99610737
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.95920606
17* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94719444
18TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86106529
19CDX2_20551321_ChIP-Seq_CACO-2_Human1.85761726
20SMAD3_21741376_ChIP-Seq_HESCs_Human1.85644995
21VDR_22108803_ChIP-Seq_LS180_Human1.85622790
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.83812793
23* CJUN_26792858_Chip-Seq_BT549_Human1.82675336
24BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.80605201
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79698905
26IGF1R_20145208_ChIP-Seq_DFB_Human1.78368469
27GATA4_25053715_ChIP-Seq_YYC3_Human1.77342836
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.75239597
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.73940654
30* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72525784
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.72350344
32* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.71491341
33P53_22127205_ChIP-Seq_FIBROBLAST_Human1.71486039
34SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68463999
35* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.67125220
36* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.67125220
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66975125
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63639419
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.63502313
40KDM2B_26808549_Chip-Seq_K562_Human1.61436242
41* ARNT_22903824_ChIP-Seq_MCF-7_Human1.61093528
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.59875791
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58097220
44SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56972289
45* AR_19668381_ChIP-Seq_PC3_Human1.56917100
46REST_21632747_ChIP-Seq_MESCs_Mouse1.56637047
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.56494929
48CTNNB1_20460455_ChIP-Seq_HCT116_Human1.55858756
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.53470225
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.52114394
51* GATA2_21666600_ChIP-Seq_HMVEC_Human1.50067579
52RARB_27405468_Chip-Seq_BRAIN_Mouse1.49986586
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.48196495
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.47745191
55EZH2_18974828_ChIP-Seq_MESCs_Mouse1.47745191
56* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47347316
57TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.46260668
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.45387590
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45295917
60ESR1_20079471_ChIP-ChIP_T-47D_Human1.44760503
61* SMAD4_21799915_ChIP-Seq_A2780_Human1.44619627
62CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41341257
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.41081698
64ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.36261287
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.35752424
66* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.32400574
67STAT3_23295773_ChIP-Seq_U87_Human1.32021354
68* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28905836
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28821627
70TAF15_26573619_Chip-Seq_HEK293_Human1.28526520
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.27926647
72* TBL1_22424771_ChIP-Seq_293T_Human1.27726175
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26557223
74BCAT_22108803_ChIP-Seq_LS180_Human1.26099004
75CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.25094052
76* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23601785
77GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22536988
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22240065
79SALL1_21062744_ChIP-ChIP_HESCs_Human1.22049938
80* TCF4_18268006_ChIP-ChIP_LS174T_Human1.21289409
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19637194
82P300_19829295_ChIP-Seq_ESCs_Human1.17784638
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17571537
84CTCF_27219007_Chip-Seq_Bcells_Human1.17403887
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17137490
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16841260
87* TP63_23658742_ChIP-Seq_EP156T_Human1.16031004
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15813807
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15800480
90YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15663858
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.15639464
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13185343
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12646261
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12316091
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.12223289
96SMAD4_21741376_ChIP-Seq_HESCs_Human1.11994437
97WDR5_24793694_ChIP-Seq_LNCAP_Human1.11946531
98* ISL1_27105846_Chip-Seq_CPCs_Mouse1.11690053
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09780799
100RXR_22108803_ChIP-Seq_LS180_Human1.09457392
101HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09076541
102* EP300_21415370_ChIP-Seq_HL-1_Mouse1.08910794
103SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08906242
104SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08906242
105PRDM14_20953172_ChIP-Seq_ESCs_Human1.08193882
106ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.06292935
107GATA6_25053715_ChIP-Seq_YYC3_Human1.05989161
108SMC4_20622854_ChIP-Seq_HELA_Human1.05804336
109TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04014440
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04012128
111CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03846536
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.03766758
113CDX2_22108803_ChIP-Seq_LS180_Human1.03685325
114CREB1_26743006_Chip-Seq_LNCaP_Human1.03353631
115SOX2_20726797_ChIP-Seq_SW620_Human1.02807642
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02706186
117* GATA3_24758297_ChIP-Seq_MCF-7_Human1.02497034
118ZNF263_19887448_ChIP-Seq_K562_Human1.01956557
119UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01941977
120TCF4_23295773_ChIP-Seq_U87_Human1.01749614
121FOXO3_23340844_ChIP-Seq_DLD1_Human1.01408394
122TP53_18474530_ChIP-ChIP_U2OS_Human1.00920223
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00436039
124TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00153291
125RING1B_27294783_Chip-Seq_ESCs_Mouse0.99272011
126TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98694373
127LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98687247
128EGR1_19032775_ChIP-ChIP_M12_Human0.98542630
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98290605
130* TBX20_22328084_ChIP-Seq_HEART_Mouse0.97887793
131* TBX20_22080862_ChIP-Seq_HEART_Mouse0.97887793
132CBP_21632823_ChIP-Seq_H3396_Human0.97630042
133* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97500561
134OCT1_27270436_Chip-Seq_PROSTATE_Human0.97403196
135* HNF4A_19822575_ChIP-Seq_HepG2_Human0.97211597
136NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.96860374
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.95643551
138MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94684635
139FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94448293
140* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94394241
141TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94256092
142* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.94042813
143RXR_22158963_ChIP-Seq_LIVER_Mouse0.94038649
144CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93969905
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93235995
146CTBP2_25329375_ChIP-Seq_LNCAP_Human0.93212285
147CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93092299
148* NFYB_21822215_ChIP-Seq_K562_Human0.92909943
149* KLF5_25053715_ChIP-Seq_YYC3_Human0.92864966
150DPY_21335234_ChIP-Seq_ESCs_Mouse0.92757485
151STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92639124
152* PHF8_20622853_ChIP-Seq_HELA_Human0.92368837
153GF1_26923725_Chip-Seq_HPCs_Mouse0.91175576
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.90483746
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90446147
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89903762
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89694106
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89694106
159PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89234556
160ER_23166858_ChIP-Seq_MCF-7_Human0.88042137
161ELK4_26923725_Chip-Seq_MESODERM_Mouse0.87748464
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87721153
163SOX2_21211035_ChIP-Seq_LN229_Gbm0.87303604
164FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87124094
165RUNX_20019798_ChIP-Seq_JUKART_Human0.86964508
166TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86488791

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0005551_abnormal_eye_electrophysiolog9.48761346
2* MP0005253_abnormal_eye_physiology6.56942212
3MP0006072_abnormal_retinal_apoptosis6.45143207
4MP0003950_abnormal_plasma_membrane3.90425124
5* MP0005195_abnormal_posterior_eye3.79496902
6MP0002090_abnormal_vision3.31979134
7MP0006054_spinal_hemorrhage3.24934122
8* MP0001324_abnormal_eye_pigmentation3.21641152
9* MP0005391_vision/eye_phenotype3.20247708
10MP0005377_hearing/vestibular/ear_phenot2.95271074
11MP0003878_abnormal_ear_physiology2.95271074
12MP0002638_abnormal_pupillary_reflex2.60534514
13MP0005423_abnormal_somatic_nervous2.51411330
14* MP0002229_neurodegeneration2.49425053
15MP0003011_delayed_dark_adaptation11.7009298
16MP0004272_abnormal_basement_membrane1.94676966
17MP0000383_abnormal_hair_follicle1.90840707
18* MP0002752_abnormal_somatic_nervous1.86772953
19MP0001764_abnormal_homeostasis1.85940380
20MP0004264_abnormal_extraembryonic_tissu1.72157477
21MP0001986_abnormal_taste_sensitivity1.71738288
22MP0003195_calcinosis1.66872212
23MP0000647_abnormal_sebaceous_gland1.66437223
24MP0010678_abnormal_skin_adnexa1.60427858
25MP0002653_abnormal_ependyma_morphology1.60157188
26MP0000566_synostosis1.58344845
27MP0002098_abnormal_vibrissa_morphology1.55086930
28MP0004233_abnormal_muscle_weight1.36681969
29* MP0002882_abnormal_neuron_morphology1.33747280
30MP0001502_abnormal_circadian_rhythm1.33190478
31MP0006292_abnormal_olfactory_placode1.24951195
32MP0005167_abnormal_blood-brain_barrier1.20370810
33MP0010234_abnormal_vibrissa_follicle1.20315794
34MP0005409_darkened_coat_color1.16198735
35MP0005360_urolithiasis1.12695767
36MP0002168_other_aberrant_phenotype1.11456259
37MP0004885_abnormal_endolymph1.06563132
38MP0005275_abnormal_skin_tensile1.05873103
39MP0001984_abnormal_olfaction1.05389050
40MP0003705_abnormal_hypodermis_morpholog1.03315505
41MP0005395_other_phenotype0.97438622
42MP0005394_taste/olfaction_phenotype0.93600233
43MP0005499_abnormal_olfactory_system0.93600233
44MP0001486_abnormal_startle_reflex0.91499643
45MP0002092_abnormal_eye_morphology0.90482350
46MP0003941_abnormal_skin_development0.89053985
47MP0004270_analgesia0.86257534
48MP0000537_abnormal_urethra_morphology0.86081336
49MP0003385_abnormal_body_wall0.83559213
50MP0002332_abnormal_exercise_endurance0.83498466
51MP0002127_abnormal_cardiovascular_syste0.82795861
52MP0000377_abnormal_hair_follicle0.81743941
53MP0008789_abnormal_olfactory_epithelium0.80653340
54MP0003879_abnormal_hair_cell0.80647080
55MP0000579_abnormal_nail_morphology0.79183321
56MP0003718_maternal_effect0.78238091
57MP0002822_catalepsy0.76945002
58MP0001958_emphysema0.76471964
59MP0000427_abnormal_hair_cycle0.75594697
60MP0003329_amyloid_beta_deposits0.72235162
61MP0003634_abnormal_glial_cell0.71769657
62* MP0004019_abnormal_vitamin_homeostasis0.70800982
63MP0000767_abnormal_smooth_muscle0.67373188
64MP0003252_abnormal_bile_duct0.66653574
65MP0000003_abnormal_adipose_tissue0.65800980
66MP0005248_abnormal_Harderian_gland0.65689541
67MP0002272_abnormal_nervous_system0.64154902
68MP0001286_abnormal_eye_development0.63753944
69MP0005023_abnormal_wound_healing0.63289542
70MP0003935_abnormal_craniofacial_develop0.62096301
71MP0008775_abnormal_heart_ventricle0.61233951
72MP0010030_abnormal_orbit_morphology0.60325591
73MP0000465_gastrointestinal_hemorrhage0.60165862
74MP0006138_congestive_heart_failure0.59761466
75MP0005187_abnormal_penis_morphology0.58859163
76MP0005670_abnormal_white_adipose0.57791320
77MP0003880_abnormal_central_pattern0.57707310
78MP0000516_abnormal_urinary_system0.55436771
79MP0005367_renal/urinary_system_phenotyp0.55436771
80MP0003984_embryonic_growth_retardation0.55353219
81MP0001963_abnormal_hearing_physiology0.54570033
82MP0005085_abnormal_gallbladder_physiolo0.54312435
83MP0008438_abnormal_cutaneous_collagen0.54046251
84* MP0002925_abnormal_cardiovascular_devel0.54016848
85MP0002734_abnormal_mechanical_nocicepti0.53938621
86MP0003453_abnormal_keratinocyte_physiol0.53739954
87MP0005503_abnormal_tendon_morphology0.53736471
88MP0003566_abnormal_cell_adhesion0.53003968
89MP0002088_abnormal_embryonic_growth/wei0.52619784
90MP0002233_abnormal_nose_morphology0.52270862
91MP0003119_abnormal_digestive_system0.51131171
92MP0002064_seizures0.51091804
93MP0004215_abnormal_myocardial_fiber0.49989745
94* MP0005197_abnormal_uvea_morphology0.49836081
95MP0005647_abnormal_sex_gland0.49442726
96MP0002896_abnormal_bone_mineralization0.49420635
97MP0003635_abnormal_synaptic_transmissio0.49356852
98MP0003942_abnormal_urinary_system0.49027774
99MP0001672_abnormal_embryogenesis/_devel0.48202730
100MP0005380_embryogenesis_phenotype0.48202730
101MP0004859_abnormal_synaptic_plasticity0.47613328
102MP0009046_muscle_twitch0.46923771
103MP0000428_abnormal_craniofacial_morphol0.46911918
104MP0003937_abnormal_limbs/digits/tail_de0.46482861
105MP0002084_abnormal_developmental_patter0.45566955
106MP0008004_abnormal_stomach_pH0.44964005
107* MP0001614_abnormal_blood_vessel0.44903248
108MP0009697_abnormal_copulation0.44890787
109MP0004782_abnormal_surfactant_physiolog0.44577481
110MP0000631_abnormal_neuroendocrine_gland0.43593489
111MP0003890_abnormal_embryonic-extraembry0.39824843
112MP0003045_fibrosis0.39631515
113MP0002067_abnormal_sensory_capabilities0.39204104
114MP0002063_abnormal_learning/memory/cond0.38599885
115MP0010368_abnormal_lymphatic_system0.37835167
116MP0005376_homeostasis/metabolism_phenot0.36476516
117MP0002697_abnormal_eye_size0.36424953
118MP0002102_abnormal_ear_morphology0.36374187
119MP0001968_abnormal_touch/_nociception0.35751463
120MP0004924_abnormal_behavior0.34814590
121MP0005386_behavior/neurological_phenoty0.34814590
122MP0002572_abnormal_emotion/affect_behav0.32211946
123MP0004145_abnormal_muscle_electrophysio0.31923082
124MP0005620_abnormal_muscle_contractility0.31572527
125MP0004085_abnormal_heartbeat0.31213922
126MP0009745_abnormal_behavioral_response0.29823161
127MP0009780_abnormal_chondrocyte_physiolo0.29678816
128MP0000026_abnormal_inner_ear0.27508781
129MP0003943_abnormal_hepatobiliary_system0.27376526
130MP0010386_abnormal_urinary_bladder0.27184024
131MP0005193_abnormal_anterior_eye0.25434588
132MP0008569_lethality_at_weaning0.24685610
133MP0002152_abnormal_brain_morphology0.24018948
134MP0004043_abnormal_pH_regulation0.23821166
135MP0005646_abnormal_pituitary_gland0.23539222
136MP0002108_abnormal_muscle_morphology0.23353304
137MP0002928_abnormal_bile_duct0.23266163
138MP0002234_abnormal_pharynx_morphology0.23238127
139MP0001879_abnormal_lymphatic_vessel0.23136426
140MP0004742_abnormal_vestibular_system0.22941972
141MP0001346_abnormal_lacrimal_gland0.21422611
142MP0001915_intracranial_hemorrhage0.21272806
143MP0005595_abnormal_vascular_smooth0.21250442
144MP0002184_abnormal_innervation0.21096847
145MP0002066_abnormal_motor_capabilities/c0.18862475
146MP0005330_cardiomyopathy0.17541634
147MP0000778_abnormal_nervous_system0.17054960
148MP0004142_abnormal_muscle_tone0.16996650
149MP0005076_abnormal_cell_differentiation0.16819688
150MP0003633_abnormal_nervous_system0.16057277
151MP0003137_abnormal_impulse_conducting0.15692690
152MP0008961_abnormal_basal_metabolism0.15664676
153MP0002909_abnormal_adrenal_gland0.15044559
154MP0000749_muscle_degeneration0.14980760
155MP0001661_extended_life_span0.14433489
156MP0004811_abnormal_neuron_physiology0.14424176
157MP0003632_abnormal_nervous_system0.13985784
158MP0005257_abnormal_intraocular_pressure0.12278540
159MP0003646_muscle_fatigue0.12112776
160MP0000751_myopathy0.11493188
161MP0001293_anophthalmia0.11094113

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)8.88107246
2Dyschromatopsia (HP:0007641)8.87507061
3Chorioretinal atrophy (HP:0000533)8.66150415
4Pendular nystagmus (HP:0012043)8.10553215
5Abolished electroretinogram (ERG) (HP:0000550)7.13298793
6* Central scotoma (HP:0000603)6.96720866
7* Scotoma (HP:0000575)6.87291497
8* Attenuation of retinal blood vessels (HP:0007843)6.84934535
9Decreased central vision (HP:0007663)6.82844181
10* Abnormality of macular pigmentation (HP:0008002)6.68321707
11* Photophobia (HP:0000613)5.75801836
12* Type II diabetes mellitus (HP:0005978)5.62643161
13Posterior subcapsular cataract (HP:0007787)5.42204884
14Severe visual impairment (HP:0001141)5.32506581
15Keratoconus (HP:0000563)5.20712374
16Increased corneal curvature (HP:0100692)5.20712374
17Vitreoretinal degeneration (HP:0000655)4.99961761
18Constricted visual fields (HP:0001133)4.92264276
19Choroideremia (HP:0001139)4.89917210
20* Macular degeneration (HP:0000608)4.44657899
21* Retinitis pigmentosa (HP:0000510)4.16772802
22Decreased electroretinogram (ERG) amplitude (HP:0000654)4.09075242
23Progressive visual loss (HP:0000529)3.48011762
24Subcapsular cataract (HP:0000523)3.41727462
25Congenital sensorineural hearing impairment (HP:0008527)3.22743508
26Tubulointerstitial nephritis (HP:0001970)3.12359478
27Hypopigmentation of the fundus (HP:0007894)3.10803290
28Retinal atrophy (HP:0001105)3.10662775
29* Cone-rod dystrophy (HP:0000548)3.07420692
30Hypoplasia of the iris (HP:0007676)2.85163364
31Proximal tubulopathy (HP:0000114)2.75069396
32Ulnar claw (HP:0001178)2.66297120
33Action tremor (HP:0002345)2.63662221
34Optic disc pallor (HP:0000543)2.56658466
35* Wide nasal bridge (HP:0000431)2.51468292
36Vascular calcification (HP:0004934)2.45000165
37Termporal pattern (HP:0011008)2.35807750
38Insidious onset (HP:0003587)2.35807750
39Bilateral sensorineural hearing impairment (HP:0008619)2.28278461
40Gait imbalance (HP:0002141)2.27148973
41Congenital primary aphakia (HP:0007707)2.26518900
42Cardiovascular calcification (HP:0011915)2.18896519
43Glomerulonephritis (HP:0000099)2.13272937
44Myocardial infarction (HP:0001658)2.05856189
45Nephrogenic diabetes insipidus (HP:0009806)2.01686063
46Tubulointerstitial abnormality (HP:0001969)2.00519570
47Congenital stationary night blindness (HP:0007642)14.9774266
48* Bony spicule pigmentary retinopathy (HP:0007737)11.3167525
49Absent rod-and cone-mediated responses on ERG (HP:0007688)10.7867502
50Abnormal rod and cone electroretinograms (HP:0008323)10.3483187
51Bronchomalacia (HP:0002780)1.98862034
52Upper limb muscle weakness (HP:0003484)1.95336379
53Increased circulating renin level (HP:0000848)1.93253243
54Segmental peripheral demyelination/remyelination (HP:0003481)1.92537116
55Subacute progressive viral hepatitis (HP:0006572)1.92337496
56Nephritis (HP:0000123)1.91479623
57Medial flaring of the eyebrow (HP:0010747)1.90331175
58Rhinitis (HP:0012384)1.90213556
59Polar cataract (HP:0010696)1.87336937
60Renal tubular acidosis (HP:0001947)1.86890486
61Hyperactive renin-angiotensin system (HP:0000841)1.86300994
62Asymmetry of the thorax (HP:0001555)1.86255442
63Hydroxyprolinuria (HP:0003080)1.84170111
64Abnormality of proline metabolism (HP:0010907)1.84170111
65Conjugated hyperbilirubinemia (HP:0002908)1.84023546
66Tubular atrophy (HP:0000092)1.82451767
67Cutaneous finger syndactyly (HP:0010554)1.81999600
68Systemic lupus erythematosus (HP:0002725)1.81801915
69Short nail (HP:0001799)1.81004622
70Progressive sensorineural hearing impairment (HP:0000408)1.78494304
71Abnormality of the distal phalanx of the thumb (HP:0009617)1.77298863
72Hypoplastic labia majora (HP:0000059)1.77210618
73Poor coordination (HP:0002370)1.74081811
74Esophageal varix (HP:0002040)1.73817619
75Hemorrhage of the eye (HP:0011885)1.71582994
76Horizontal nystagmus (HP:0000666)1.66614138
77True hermaphroditism (HP:0010459)1.65830450
78Cervical subluxation (HP:0003308)1.65210610
79Interstitial pulmonary disease (HP:0006530)1.65069445
80Abnormal pupillary function (HP:0007686)1.64720146
81Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.64365328
82Bell-shaped thorax (HP:0001591)1.63927125
83Absent eyebrow (HP:0002223)1.63869948
84Abnormality of the dental root (HP:0006486)1.61992233
85Taurodontia (HP:0000679)1.61992233
86Abnormality of permanent molar morphology (HP:0011071)1.61992233
87Right ventricular cardiomyopathy (HP:0011663)1.60323084
88Abnormality of the renal medulla (HP:0100957)1.60254239
89Abnormality of the labia majora (HP:0012881)1.60203858
90Nonimmune hydrops fetalis (HP:0001790)1.59741301
91Bicornuate uterus (HP:0000813)1.59507762
92* Optic atrophy (HP:0000648)1.57790419
93Pancreatic fibrosis (HP:0100732)1.57489381
94Abnormality of the fovea (HP:0000493)1.57456012
95Protrusio acetabuli (HP:0003179)1.56937647
96Vaginal atresia (HP:0000148)1.56895672
97Ulnar bowing (HP:0003031)1.56688974
98Renal salt wasting (HP:0000127)1.56635207
99Abnormality of the dental pulp (HP:0006479)1.56141752
100Complement deficiency (HP:0004431)1.55936974
101Abnormality of monocarboxylic acid metabolism (HP:0010996)1.55265529
102Abnormality of molar morphology (HP:0011070)1.52960707
103Abnormality of molar (HP:0011077)1.52960707
104Decreased lacrimation (HP:0000633)1.52602503
105Abnormal ciliary motility (HP:0012262)1.52590489
106Tubulointerstitial fibrosis (HP:0005576)1.51774573
107Micronodular cirrhosis (HP:0001413)1.51513918
108Increased CSF protein (HP:0002922)1.51374663
109Severe Myopia (HP:0011003)1.50844598
110Abnormal auditory evoked potentials (HP:0006958)1.50744251
111Hyperkalemia (HP:0002153)1.50462046
112Genital tract atresia (HP:0001827)1.50320161
113Sex reversal (HP:0012245)1.49638516
114Abnormal sex determination (HP:0012244)1.49638516
115Epidermoid cyst (HP:0200040)1.48149037
116Advanced eruption of teeth (HP:0006288)1.46749741
117Hypoplasia of the fovea (HP:0007750)1.44107692
118Aplasia/Hypoplasia of the fovea (HP:0008060)1.44107692
119Febrile seizures (HP:0002373)1.36749547
120Aplasia/Hypoplasia of the lens (HP:0008063)1.35556915
121Epileptic encephalopathy (HP:0200134)1.34819512
122Dysdiadochokinesis (HP:0002075)1.29994114
123Cystic liver disease (HP:0006706)1.25783562
124Retinal detachment (HP:0000541)1.24681121
125Pancreatic cysts (HP:0001737)1.23756849
126Astigmatism (HP:0000483)1.17818399
127Aplasia/Hypoplasia of the tongue (HP:0010295)1.17120062
128Chorioretinal coloboma (HP:0000567)1.12111584
129Aplasia/Hypoplasia of the macula (HP:0008059)1.09521946
130Sclerocornea (HP:0000647)1.01019464
131Aplasia/Hypoplasia affecting the retina (HP:0008061)0.99366611
132Progressive cerebellar ataxia (HP:0002073)0.98860488
133Visual hallucinations (HP:0002367)0.98366636
134Truncal ataxia (HP:0002078)0.98096509
135Left ventricular hypertrophy (HP:0001712)0.97716832
136Prolonged QT interval (HP:0001657)0.96694057
137Recurrent sinusitis (HP:0011108)0.94691439
138Abnormality of the fingertips (HP:0001211)0.93727514
139Hypermetropia (HP:0000540)0.93707887
140Genetic anticipation (HP:0003743)0.91774526
141Broad foot (HP:0001769)0.90895923
142Specific learning disability (HP:0001328)0.89856347
143Furrowed tongue (HP:0000221)0.88121098
144Abnormality of midbrain morphology (HP:0002418)0.83941733
145Molar tooth sign on MRI (HP:0002419)0.83941733
146Chronic hepatic failure (HP:0100626)0.83257994
147Decreased testicular size (HP:0008734)0.82846861
148Asthma (HP:0002099)0.82413857
149Macroorchidism (HP:0000053)0.82219154
150Septo-optic dysplasia (HP:0100842)0.80720442
151Abnormality of dental color (HP:0011073)0.79000998
152Corneal dystrophy (HP:0001131)0.76553521
153Congenital hepatic fibrosis (HP:0002612)0.75347581
154Abnormal EKG (HP:0003115)0.75064191
155Anencephaly (HP:0002323)0.73266816
156Syncope (HP:0001279)0.71440328
157Broad-based gait (HP:0002136)0.71186992
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)0.70753532
159Postaxial hand polydactyly (HP:0001162)0.69959272
160Nephronophthisis (HP:0000090)0.67133909
161Aqueductal stenosis (HP:0002410)0.66169718
162Postaxial foot polydactyly (HP:0001830)0.64810443
163Hypodontia (HP:0000668)0.64460325
164Hypoventilation (HP:0002791)0.63979042
165Abnormality of the parathyroid morphology (HP:0011766)0.63823331
166Depression (HP:0000716)0.62463726
167Dental crowding (HP:0000678)0.62392878
168Postural instability (HP:0002172)0.62090613

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.19501084
2PBK4.73205004
3MET3.86463259
4TIE13.51216277
5PINK13.27734484
6STK393.26222061
7EPHA23.02328732
8STK38L2.94918636
9LATS22.58965905
10OXSR12.38970414
11IRAK22.19661342
12GRK111.8137298
13MAP3K101.82368485
14EPHB21.80662294
15CAMK1G1.77164873
16STK241.76495221
17MUSK1.76151162
18PTK2B1.74388726
19SIK21.68024742
20CAMK1D1.63193958
21CDK121.62763848
22INSRR1.59895001
23MAPK71.51777153
24FER1.44890649
25TTN1.43150380
26HIPK21.42669635
27ADRBK11.42467518
28MAPK121.41051610
29BMX1.40044667
30BRD41.39118749
31STK381.38886323
32PAK61.35936639
33NME11.32467355
34PTK21.32371520
35MARK21.27897695
36KDR1.23886309
37STK31.22401982
38TAOK31.21170069
39SGK2231.16746381
40SGK4941.16746381
41SGK21.16078334
42ERBB21.12778369
43SGK31.08591227
44CSNK1D1.06978471
45RPS6KA41.05602255
46MAP3K41.03628031
47PDK21.01361934
48MARK11.00935320
49PRKD30.99258048
50MST40.98954452
51WNK10.97855489
52PRKCH0.95103815
53CAMKK10.94422893
54TRPM70.94054840
55DYRK1A0.90113567
56ICK0.89824049
57ACVR1B0.86435439
58NEK10.86390045
59PDGFRA0.85696065
60PRKCZ0.78230778
61TTK0.77157111
62NEK90.76902958
63MTOR0.75809608
64MKNK20.75071277
65PRKAA10.75005763
66CDK30.74792028
67TGFBR10.74386591
68AKT30.73890738
69BRSK20.73774789
70LATS10.73445549
71PRKAA20.72883874
72PRKCB0.72179585
73MAP3K20.68786126
74SIK10.67147469
75PNCK0.67041508
76MAP2K70.64223251
77CAMK2D0.63144871
78CDK90.61947833
79PRKD20.61496986
80PDGFRB0.61051812
81TGFBR20.61040808
82ERBB40.60419456
83DYRK1B0.60413828
84SGK10.59218750
85GRK50.58868525
86RPS6KA30.57670580
87CAMK10.57402068
88FRK0.57261966
89NEK20.56320320
90MAP3K70.55218731
91PHKG10.54813874
92PHKG20.54813874
93PRKACG0.53738213
94PLK20.53399021
95PAK40.52721756
96ERN10.52217746
97CAMK40.51597925
98BMPR1B0.50934850
99GSK3B0.50765715
100AKT20.50472598
101MAP3K30.48694242
102MAPK140.48635401
103FGFR10.48164731
104PRKDC0.46921122
105BCR0.46534258
106MAPK100.45468385
107MYLK0.44537727
108PRKG20.43852321
109CDK50.43410187
110MAPK90.42825367
111FES0.42581901
112FGFR20.42064185
113NEK60.40987627
114STK110.39790117
115DDR20.38529357
116PLK30.37535947
117IGF1R0.37451075
118CDK10.36863255
119FGFR30.36146399
120NTRK10.35984958
121CASK0.35767618
122CDC42BPA0.34926765
123RPS6KB10.34788536
124RET0.34690129
125PKN10.34490920
126YES10.33307988
127EPHA30.31934212
128PRKACA0.31071285
129PRKCI0.28810286
130SRC0.28303374
131FGFR40.27726104
132CCNB10.27519840
133PRKCA0.27516090
134RIPK10.27045176
135ATM0.25382365
136MAPK80.25341244
137PIK3CA0.25329294
138CHEK20.25043489
139PTK60.24917441
140MAP2K40.24740420
141PRKD10.24695747
142ALK0.24556642
143CAMK2A0.24426580
144ATR0.24210167
145TRIB30.24162602
146CAMK2G0.24023823
147PRKG10.22681652
148MAPK30.22561776
149BRSK10.22551041
150MINK10.22442175
151IRAK30.22418809
152MAP3K90.22082033
153CAMK2B0.21509890
154CDK70.21176604
155NUAK10.21161688
156PRKCG0.20878270
157MAPK10.20843150
158WNK40.20796888
159MAP3K60.19917544
160IRAK10.18981777
161ROCK10.17606605
162CHUK0.15996282
163INSR0.15168008
164PRKCE0.13416300

Predicted pathways (KEGG)

RankGene SetZ-score
1Adherens junction_Homo sapiens_hsa045202.44465627
2Complement and coagulation cascades_Homo sapiens_hsa046102.24459813
3Fatty acid biosynthesis_Homo sapiens_hsa000612.17079007
4* ABC transporters_Homo sapiens_hsa020102.13714712
5Histidine metabolism_Homo sapiens_hsa003402.10251588
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09187097
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.04665952
8Phototransduction_Homo sapiens_hsa0474415.7352078
9ECM-receptor interaction_Homo sapiens_hsa045121.69345025
10Synaptic vesicle cycle_Homo sapiens_hsa047211.65161884
11Steroid hormone biosynthesis_Homo sapiens_hsa001401.65103043
12Basal cell carcinoma_Homo sapiens_hsa052171.58755674
13Olfactory transduction_Homo sapiens_hsa047401.47206821
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41285560
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.37536480
16Starch and sucrose metabolism_Homo sapiens_hsa005001.36677307
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.36637527
18PPAR signaling pathway_Homo sapiens_hsa033201.32735304
19Fatty acid metabolism_Homo sapiens_hsa012121.32576133
20GABAergic synapse_Homo sapiens_hsa047271.26546530
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24339768
22Focal adhesion_Homo sapiens_hsa045101.21131801
23Fatty acid degradation_Homo sapiens_hsa000711.19913163
24Hedgehog signaling pathway_Homo sapiens_hsa043401.19621976
25Chemical carcinogenesis_Homo sapiens_hsa052041.18637238
26Vitamin digestion and absorption_Homo sapiens_hsa049771.17416229
27Glutathione metabolism_Homo sapiens_hsa004801.15765796
28Tryptophan metabolism_Homo sapiens_hsa003801.12270095
29Sphingolipid metabolism_Homo sapiens_hsa006001.07520431
30Circadian rhythm_Homo sapiens_hsa047101.05341514
31Propanoate metabolism_Homo sapiens_hsa006401.04099105
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03480835
33Retinol metabolism_Homo sapiens_hsa008301.01501026
34Axon guidance_Homo sapiens_hsa043600.99937925
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99644518
36Proteoglycans in cancer_Homo sapiens_hsa052050.97030232
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97009274
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96244748
39Cholinergic synapse_Homo sapiens_hsa047250.94161534
40beta-Alanine metabolism_Homo sapiens_hsa004100.89809105
41Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.89645257
42Morphine addiction_Homo sapiens_hsa050320.87179875
43Circadian entrainment_Homo sapiens_hsa047130.85970140
44Butanoate metabolism_Homo sapiens_hsa006500.85492208
45TGF-beta signaling pathway_Homo sapiens_hsa043500.84885927
46Dorso-ventral axis formation_Homo sapiens_hsa043200.83584590
47Thyroid cancer_Homo sapiens_hsa052160.82787300
48Glutamatergic synapse_Homo sapiens_hsa047240.81980558
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.81713080
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79146851
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78822815
52Protein digestion and absorption_Homo sapiens_hsa049740.76483169
53Notch signaling pathway_Homo sapiens_hsa043300.75760411
54Pyruvate metabolism_Homo sapiens_hsa006200.75678047
55Phenylalanine metabolism_Homo sapiens_hsa003600.74717881
56Dopaminergic synapse_Homo sapiens_hsa047280.72563177
57Nitrogen metabolism_Homo sapiens_hsa009100.71801531
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69966450
59Insulin secretion_Homo sapiens_hsa049110.68301159
60Nicotine addiction_Homo sapiens_hsa050330.68046537
61Serotonergic synapse_Homo sapiens_hsa047260.64835229
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64239785
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63603357
64Small cell lung cancer_Homo sapiens_hsa052220.63305775
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.62333761
66Fat digestion and absorption_Homo sapiens_hsa049750.61055768
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60114881
68Peroxisome_Homo sapiens_hsa041460.59749888
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.59666055
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59583147
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.58050976
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55691285
73Oxytocin signaling pathway_Homo sapiens_hsa049210.53678712
74Arachidonic acid metabolism_Homo sapiens_hsa005900.53490342
75Other glycan degradation_Homo sapiens_hsa005110.52104031
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50442497
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50304233
78MicroRNAs in cancer_Homo sapiens_hsa052060.49600506
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.48849610
80Dilated cardiomyopathy_Homo sapiens_hsa054140.48148204
81Pathways in cancer_Homo sapiens_hsa052000.47925908
82Rap1 signaling pathway_Homo sapiens_hsa040150.47871735
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46074486
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45989221
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45840006
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44360124
87N-Glycan biosynthesis_Homo sapiens_hsa005100.43382174
88Arginine and proline metabolism_Homo sapiens_hsa003300.42934248
89Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42374459
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42314674
91Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42262958
92Salivary secretion_Homo sapiens_hsa049700.42230725
93Linoleic acid metabolism_Homo sapiens_hsa005910.41941685
94Ether lipid metabolism_Homo sapiens_hsa005650.41911511
95Vibrio cholerae infection_Homo sapiens_hsa051100.41835859
96cAMP signaling pathway_Homo sapiens_hsa040240.40653057
97PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40503311
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.39774749
99Renin secretion_Homo sapiens_hsa049240.38939013
100Fructose and mannose metabolism_Homo sapiens_hsa000510.38386266
101Inositol phosphate metabolism_Homo sapiens_hsa005620.38279655
102Renin-angiotensin system_Homo sapiens_hsa046140.37628089
103Gastric acid secretion_Homo sapiens_hsa049710.36823140
104mTOR signaling pathway_Homo sapiens_hsa041500.35891412
105Purine metabolism_Homo sapiens_hsa002300.35773365
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35308377
107Cardiac muscle contraction_Homo sapiens_hsa042600.34972384
108Lysine degradation_Homo sapiens_hsa003100.34519102
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32274170
110Caffeine metabolism_Homo sapiens_hsa002320.30779073
111Glycerolipid metabolism_Homo sapiens_hsa005610.29996656
112Cocaine addiction_Homo sapiens_hsa050300.29920670
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28729765
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.26616687
115Long-term potentiation_Homo sapiens_hsa047200.25842896
116Central carbon metabolism in cancer_Homo sapiens_hsa052300.24953448
117Type II diabetes mellitus_Homo sapiens_hsa049300.24674828
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.23503091
119Glucagon signaling pathway_Homo sapiens_hsa049220.23221773
120Calcium signaling pathway_Homo sapiens_hsa040200.22701335
121HIF-1 signaling pathway_Homo sapiens_hsa040660.22597643
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22589371
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.22451510
124Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.22379462
125Amphetamine addiction_Homo sapiens_hsa050310.21060830
126Bile secretion_Homo sapiens_hsa049760.20078212
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20048830
128Chemokine signaling pathway_Homo sapiens_hsa040620.19341434
129AMPK signaling pathway_Homo sapiens_hsa041520.18086679
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17899447
131GnRH signaling pathway_Homo sapiens_hsa049120.17811439
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16483396
133MAPK signaling pathway_Homo sapiens_hsa040100.16341551
134Arginine biosynthesis_Homo sapiens_hsa002200.16212352
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.16123623
136Pancreatic secretion_Homo sapiens_hsa049720.16010558
137Ras signaling pathway_Homo sapiens_hsa040140.14716214
138Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14463667
139Tight junction_Homo sapiens_hsa045300.14382846
140Galactose metabolism_Homo sapiens_hsa000520.13549094
141Mineral absorption_Homo sapiens_hsa049780.12948798
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12869318
143Thyroid hormone synthesis_Homo sapiens_hsa049180.12764373
144Insulin resistance_Homo sapiens_hsa049310.12699644
145Alcoholism_Homo sapiens_hsa050340.11604290
146Glioma_Homo sapiens_hsa052140.11510536
147Choline metabolism in cancer_Homo sapiens_hsa052310.11267051
148Phospholipase D signaling pathway_Homo sapiens_hsa040720.10599774
149Maturity onset diabetes of the young_Homo sapiens_hsa049500.10153486
150Fatty acid elongation_Homo sapiens_hsa000620.09349944
151Hippo signaling pathway_Homo sapiens_hsa043900.09231655
152Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09127655
153Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.08450426
154Ovarian steroidogenesis_Homo sapiens_hsa049130.08287332
155Wnt signaling pathway_Homo sapiens_hsa043100.08243153
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08032581
157Taste transduction_Homo sapiens_hsa047420.07909317
158Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07716065
159Melanogenesis_Homo sapiens_hsa049160.06549569
160Adipocytokine signaling pathway_Homo sapiens_hsa049200.06492503
161Collecting duct acid secretion_Homo sapiens_hsa049660.06045915
162mRNA surveillance pathway_Homo sapiens_hsa030150.05936725
163ErbB signaling pathway_Homo sapiens_hsa040120.05873305
164Renal cell carcinoma_Homo sapiens_hsa052110.05812888
165Biosynthesis of amino acids_Homo sapiens_hsa012300.05228082
166Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05124262
167Non-small cell lung cancer_Homo sapiens_hsa052230.04627621

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