ABCA5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24, but neither the substrate nor the function of this gene is known. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52782291
2positive regulation of glycolytic process (GO:0045821)4.00941914
3regulation of synaptic vesicle exocytosis (GO:2000300)3.79422312
4negative regulation of cytosolic calcium ion concentration (GO:0051481)3.77865933
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.74421111
6cellular ketone body metabolic process (GO:0046950)3.71080651
7synaptic vesicle exocytosis (GO:0016079)3.66450976
8cilium or flagellum-dependent cell motility (GO:0001539)3.64413122
9glutamate secretion (GO:0014047)3.63156856
10regulation of type B pancreatic cell apoptotic process (GO:2000674)3.62524103
11axoneme assembly (GO:0035082)3.56979062
12macroautophagy (GO:0016236)3.53079296
13synaptic vesicle maturation (GO:0016188)3.47959971
14regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.46184141
15regulation of hexokinase activity (GO:1903299)3.44332822
16regulation of glucokinase activity (GO:0033131)3.44332822
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.43589028
18ketone body metabolic process (GO:1902224)3.42446504
19regulation of energy homeostasis (GO:2000505)3.41967585
20neuronal action potential propagation (GO:0019227)3.40475216
21neuron cell-cell adhesion (GO:0007158)3.38390947
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.38088474
23locomotory exploration behavior (GO:0035641)3.37577165
24regulation of synaptic vesicle transport (GO:1902803)3.36670284
25cilium movement (GO:0003341)3.32313077
26drug catabolic process (GO:0042737)3.31700566
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.30936273
28vocalization behavior (GO:0071625)3.28904325
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27316167
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.24875189
31proline transport (GO:0015824)3.24641885
32protein localization to synapse (GO:0035418)3.23978297
33exogenous drug catabolic process (GO:0042738)3.18795343
34inositol phosphate catabolic process (GO:0071545)3.16747177
35synaptic transmission, glutamatergic (GO:0035249)3.15187449
36cerebellar Purkinje cell differentiation (GO:0021702)3.13566741
37epithelial cilium movement (GO:0003351)3.11167179
38detection of calcium ion (GO:0005513)3.09564500
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08828359
40regulation of glutamate receptor signaling pathway (GO:1900449)3.07470796
41cellular potassium ion homeostasis (GO:0030007)3.05729246
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.04460087
43neuron-neuron synaptic transmission (GO:0007270)3.01725087
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.00924252
45neurotransmitter secretion (GO:0007269)3.00687321
46regulation of cilium movement (GO:0003352)2.98096810
47membrane depolarization during action potential (GO:0086010)2.96912207
48glutamate receptor signaling pathway (GO:0007215)2.96563714
49innervation (GO:0060384)2.91151004
50brain morphogenesis (GO:0048854)2.90080140
51Golgi to endosome transport (GO:0006895)2.87684832
52gamma-aminobutyric acid transport (GO:0015812)2.87014244
53carnitine transport (GO:0015879)2.85306577
54amino-acid betaine transport (GO:0015838)2.85306577
55polyol catabolic process (GO:0046174)2.84787010
56endocrine pancreas development (GO:0031018)2.84523164
57presynaptic membrane assembly (GO:0097105)2.83897683
58axonal fasciculation (GO:0007413)2.83366411
59potassium ion homeostasis (GO:0055075)2.80480872
60protein targeting to Golgi (GO:0000042)2.80228148
61activation of protein kinase A activity (GO:0034199)2.79961536
62cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.79766654
63neuron recognition (GO:0008038)2.77569244
64renal tubule morphogenesis (GO:0061333)2.77489881
65fatty acid transmembrane transport (GO:1902001)2.77331201
66transmission of nerve impulse (GO:0019226)2.74104268
67gamma-aminobutyric acid signaling pathway (GO:0007214)2.73989020
68regulation of neuronal synaptic plasticity (GO:0048168)2.72681082
69epoxygenase P450 pathway (GO:0019373)2.71647650
70regulation of protein glycosylation (GO:0060049)2.71528178
71regulation of neurotransmitter secretion (GO:0046928)2.68617668
72response to pheromone (GO:0019236)2.67604593
73dendrite morphogenesis (GO:0048813)2.65786486
74regulation of excitatory postsynaptic membrane potential (GO:0060079)2.65754972
75chemosensory behavior (GO:0007635)2.65411827
76vesicle transport along microtubule (GO:0047496)2.64767365
77neurotransmitter transport (GO:0006836)2.64338909
78regulation of vesicle fusion (GO:0031338)2.62420656
79neuronal action potential (GO:0019228)2.61828737
80exploration behavior (GO:0035640)2.61579141
81carnitine transmembrane transport (GO:1902603)2.61487586
82regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.60364914
83regulation of postsynaptic membrane potential (GO:0060078)2.60165762
84regulation of long-term neuronal synaptic plasticity (GO:0048169)2.60027632
85nephron epithelium morphogenesis (GO:0072088)2.59767152
86nephron tubule morphogenesis (GO:0072078)2.59767152
87positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.59637635
88layer formation in cerebral cortex (GO:0021819)2.58845775
89nerve growth factor signaling pathway (GO:0038180)2.58399406
90inositol phosphate dephosphorylation (GO:0046855)2.58136763
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.58136763
92axonemal dynein complex assembly (GO:0070286)2.57874423
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.57501242
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56913689
95positive regulation of insulin secretion (GO:0032024)2.55515275
96negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.55381651
97synaptic vesicle endocytosis (GO:0048488)2.54736402
98dopamine transport (GO:0015872)2.54682773
99presynaptic membrane organization (GO:0097090)2.53953572
100cell communication by electrical coupling (GO:0010644)2.53850040
101water-soluble vitamin biosynthetic process (GO:0042364)2.53497786
102positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.53130864
103negative regulation of complement activation (GO:0045916)2.52057322
104establishment of protein localization to Golgi (GO:0072600)2.51968438
105regulation of glycolytic process (GO:0006110)2.51427854
106fatty acid homeostasis (GO:0055089)2.51220898
107neurotransmitter-gated ion channel clustering (GO:0072578)2.50921308
108long-term memory (GO:0007616)2.50510554
109response to auditory stimulus (GO:0010996)2.50427402
110long-term synaptic potentiation (GO:0060291)2.50425066
111membrane depolarization (GO:0051899)2.50129434
112urinary tract smooth muscle contraction (GO:0014848)2.49777877
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.49145451
114alanine transport (GO:0032328)2.48021639
115carnitine shuttle (GO:0006853)2.47418811
116ER overload response (GO:0006983)2.46504630
117calcium ion-dependent exocytosis (GO:0017156)2.45821385
118regulation of ARF protein signal transduction (GO:0032012)2.45479257
119positive regulation of peptide hormone secretion (GO:0090277)2.45199785
120negative regulation of protein activation cascade (GO:2000258)2.44141089
121neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.43956063
122regulation of neurotransmitter transport (GO:0051588)2.43816931
123regulation of synaptic transmission, glutamatergic (GO:0051966)2.43501664
124ethanol oxidation (GO:0006069)2.42206773
125synapse assembly (GO:0007416)2.42007136
126regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.41997347
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.41900499
128tryptophan catabolic process (GO:0006569)2.41167457
129indole-containing compound catabolic process (GO:0042436)2.41167457
130indolalkylamine catabolic process (GO:0046218)2.41167457
131positive regulation of potassium ion transport (GO:0043268)2.41000000
132G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40337174
133protein localization to Golgi apparatus (GO:0034067)2.40301397
134retrograde transport, vesicle recycling within Golgi (GO:0000301)2.39914019
135regulation of synaptic plasticity (GO:0048167)2.39872580
136regulation of calcium ion-dependent exocytosis (GO:0017158)2.39704323
137oxidative demethylation (GO:0070989)2.39450493
138reflex (GO:0060004)2.39256389
139flavonoid metabolic process (GO:0009812)2.38343875
140peptide hormone processing (GO:0016486)2.37978124
141cell communication involved in cardiac conduction (GO:0086065)2.37869898
142regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.37348527
143membrane hyperpolarization (GO:0060081)2.37327706
144cellular response to ethanol (GO:0071361)2.37081036
145synapse organization (GO:0050808)2.36563604
146postsynaptic membrane organization (GO:0001941)2.36305622
147insulin secretion (GO:0030073)2.35541801
148positive regulation of peptide secretion (GO:0002793)2.34245920
149adult walking behavior (GO:0007628)2.34134801
150cellular sodium ion homeostasis (GO:0006883)2.34119440
151organelle transport along microtubule (GO:0072384)2.33869315
152negative regulation of hormone biosynthetic process (GO:0032353)2.33294120
153neuronal ion channel clustering (GO:0045161)2.33074100
154protein localization to cilium (GO:0061512)2.33001364
155synaptic transmission (GO:0007268)2.32506028
156vitamin transmembrane transport (GO:0035461)2.32452888
157inner ear receptor cell development (GO:0060119)2.32254722
158regulation of relaxation of muscle (GO:1901077)2.32247612
159regulation of synapse structural plasticity (GO:0051823)2.31787802
160early endosome to late endosome transport (GO:0045022)2.31665133
161sensory perception of smell (GO:0007608)2.31658510
162apical protein localization (GO:0045176)2.31147681
163mating behavior (GO:0007617)2.30597255
164neuromuscular synaptic transmission (GO:0007274)2.30495969
165negative regulation of hormone metabolic process (GO:0032351)2.29688494
166positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28844136
167regulation of neurotransmitter levels (GO:0001505)2.28553624
168nitric oxide mediated signal transduction (GO:0007263)2.28215722
169short-chain fatty acid metabolic process (GO:0046459)2.27282758
1703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.26939844
171purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.26939844
172detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26881490
173interkinetic nuclear migration (GO:0022027)2.26798369
174aromatic amino acid family catabolic process (GO:0009074)2.25761855
175cilium organization (GO:0044782)2.24871052
176relaxation of cardiac muscle (GO:0055119)2.22549417
177benzene-containing compound metabolic process (GO:0042537)2.22124067
178quaternary ammonium group transport (GO:0015697)2.22071210
179indolalkylamine metabolic process (GO:0006586)2.21364785
180regulation of cell communication by electrical coupling (GO:0010649)2.21049190
181cilium assembly (GO:0042384)2.20644870
182vascular smooth muscle contraction (GO:0014829)2.20502080
183triglyceride homeostasis (GO:0070328)2.20493963
184acylglycerol homeostasis (GO:0055090)2.20493963
185action potential (GO:0001508)2.20158151
186dopamine biosynthetic process (GO:0042416)2.19571704
187response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.19504800
188cAMP catabolic process (GO:0006198)2.17604532
189intra-Golgi vesicle-mediated transport (GO:0006891)2.16930429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.29207806
2GBX2_23144817_ChIP-Seq_PC3_Human3.49810389
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.84520761
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54000628
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49780361
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28160937
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.16287859
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09939897
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09939897
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07823485
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06153942
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04199255
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03755509
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.03354556
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.03159558
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.98183995
17* EED_16625203_ChIP-ChIP_MESCs_Mouse1.97592539
18REST_21632747_ChIP-Seq_MESCs_Mouse1.86243430
19DROSHA_22980978_ChIP-Seq_HELA_Human1.85800129
20SMAD4_21799915_ChIP-Seq_A2780_Human1.84893426
21TAF15_26573619_Chip-Seq_HEK293_Human1.84090933
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79330695
23* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78889899
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.77715336
25PIAS1_25552417_ChIP-Seq_VCAP_Human1.77200056
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75476913
27PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74878393
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73202989
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72282342
30FUS_26573619_Chip-Seq_HEK293_Human1.71520804
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70738916
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70213300
33* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67324110
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64316007
35AR_21572438_ChIP-Seq_LNCaP_Human1.64258897
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62397750
37IGF1R_20145208_ChIP-Seq_DFB_Human1.60160498
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59812166
39BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57878989
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56951136
41* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56638151
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54129250
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51627750
44* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.49281220
45* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48968471
46P300_19829295_ChIP-Seq_ESCs_Human1.48651286
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48459399
48CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.47632903
49STAT3_23295773_ChIP-Seq_U87_Human1.46848573
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.44265047
51AHR_22903824_ChIP-Seq_MCF-7_Human1.44110034
52EZH2_27294783_Chip-Seq_NPCs_Mouse1.42242763
53* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41080474
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40825534
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39893087
56ARNT_22903824_ChIP-Seq_MCF-7_Human1.39403958
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37923296
58AR_25329375_ChIP-Seq_VCAP_Human1.37129277
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.36700596
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.33379244
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.32940589
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32908107
63CBP_20019798_ChIP-Seq_JUKART_Human1.32908107
64ZNF274_21170338_ChIP-Seq_K562_Hela1.32600419
65* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32541711
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.30569256
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29757955
68CDX2_22108803_ChIP-Seq_LS180_Human1.27453398
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.26681364
70PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26455749
71* TCF4_23295773_ChIP-Seq_U87_Human1.26131104
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23621804
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.23256584
74FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22353091
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20226522
76GATA1_22025678_ChIP-Seq_K562_Human1.20182672
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18829374
78TCF4_22108803_ChIP-Seq_LS180_Human1.18423377
79CRX_20693478_ChIP-Seq_RETINA_Mouse1.16751582
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16610136
81NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16556336
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16317838
83ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.16286889
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15191772
85VDR_22108803_ChIP-Seq_LS180_Human1.15100074
86BCAT_22108803_ChIP-Seq_LS180_Human1.14960775
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.14818813
88TP53_18474530_ChIP-ChIP_U2OS_Human1.14806272
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.14360593
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.13810367
91FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13738902
92RUNX2_22187159_ChIP-Seq_PCA_Human1.13638786
93* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13209723
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.12730063
95AR_19668381_ChIP-Seq_PC3_Human1.12648957
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.11593517
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10513871
98AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09595764
99OCT4_21477851_ChIP-Seq_ESCs_Mouse1.09273237
100SOX2_19829295_ChIP-Seq_ESCs_Human1.09185663
101NANOG_19829295_ChIP-Seq_ESCs_Human1.09185663
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09012817
103EWS_26573619_Chip-Seq_HEK293_Human1.08976960
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.08934154
105TP53_16413492_ChIP-PET_HCT116_Human1.08042119
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07903994
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07903994
108RNF2_27304074_Chip-Seq_NSC_Mouse1.07720090
109ER_23166858_ChIP-Seq_MCF-7_Human1.07053319
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06983330
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06705715
112SOX2_18555785_Chip-Seq_ESCs_Mouse1.06105329
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.05517320
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05456166
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05425678
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04943366
117P300_18555785_Chip-Seq_ESCs_Mouse1.04570150
118RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02470027
119HTT_18923047_ChIP-ChIP_STHdh_Human1.02413071
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02031566
121IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01830051
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00664119
123TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00140345
124SMAD4_21741376_ChIP-Seq_HESCs_Human0.98060657
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97683379
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96206344
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96206344
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96019549
129* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95374670
130E2F1_18555785_Chip-Seq_ESCs_Mouse0.95345677
131RING1B_27294783_Chip-Seq_ESCs_Mouse0.94884293
132ERG_21242973_ChIP-ChIP_JURKAT_Human0.94297938
133P53_22387025_ChIP-Seq_ESCs_Mouse0.92845299
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.92122869
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91538410
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.90869939
137CMYC_18555785_Chip-Seq_ESCs_Mouse0.90577258

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.24627848
2MP0004270_analgesia3.32740856
3MP0003880_abnormal_central_pattern3.12166077
4MP0009780_abnormal_chondrocyte_physiolo3.04425612
5MP0003635_abnormal_synaptic_transmissio2.99885375
6MP0001968_abnormal_touch/_nociception2.77056496
7MP0002735_abnormal_chemical_nociception2.71150624
8MP0002734_abnormal_mechanical_nocicepti2.62935011
9MP0001984_abnormal_olfaction2.50280774
10MP0009745_abnormal_behavioral_response2.48139426
11MP0009046_muscle_twitch2.46481476
12MP0002063_abnormal_learning/memory/cond2.38785487
13MP0002064_seizures2.27550637
14MP0002736_abnormal_nociception_after2.25535533
15MP0002272_abnormal_nervous_system2.24831896
16MP0010386_abnormal_urinary_bladder2.23474545
17MP0002909_abnormal_adrenal_gland2.21098784
18MP0005085_abnormal_gallbladder_physiolo2.19404016
19MP0002139_abnormal_hepatobiliary_system2.16714086
20MP0003646_muscle_fatigue2.12094595
21MP0002572_abnormal_emotion/affect_behav2.11115475
22MP0008875_abnormal_xenobiotic_pharmacok2.07808903
23MP0002638_abnormal_pupillary_reflex2.04399562
24MP0004043_abnormal_pH_regulation2.00761286
25MP0001486_abnormal_startle_reflex1.97228188
26MP0010234_abnormal_vibrissa_follicle1.95120980
27MP0002733_abnormal_thermal_nociception1.92600641
28MP0002184_abnormal_innervation1.83581027
29MP0000427_abnormal_hair_cycle1.83033272
30MP0001970_abnormal_pain_threshold1.82502360
31MP0010329_abnormal_lipoprotein_level1.82224079
32MP0005365_abnormal_bile_salt1.81395843
33MP0001501_abnormal_sleep_pattern1.80457329
34MP0005646_abnormal_pituitary_gland1.78986619
35MP0002067_abnormal_sensory_capabilities1.78607140
36MP0003252_abnormal_bile_duct1.77182863
37MP0005332_abnormal_amino_acid1.70817469
38MP0001440_abnormal_grooming_behavior1.70458245
39MP0005423_abnormal_somatic_nervous1.69719465
40MP0006276_abnormal_autonomic_nervous1.68419123
41MP0002557_abnormal_social/conspecific_i1.62562121
42MP0004858_abnormal_nervous_system1.61923138
43MP0005645_abnormal_hypothalamus_physiol1.58735964
44MP0010678_abnormal_skin_adnexa1.55699757
45MP0000383_abnormal_hair_follicle1.55557484
46MP0000778_abnormal_nervous_system1.54787812
47MP0005360_urolithiasis1.46972670
48MP0000955_abnormal_spinal_cord1.45638332
49MP0004019_abnormal_vitamin_homeostasis1.44138889
50MP0003183_abnormal_peptide_metabolism1.40577305
51MP0000015_abnormal_ear_pigmentation1.40191902
52MP0000013_abnormal_adipose_tissue1.39995667
53MP0000372_irregular_coat_pigmentation1.39350892
54MP0004145_abnormal_muscle_electrophysio1.38690612
55MP0002078_abnormal_glucose_homeostasis1.38396868
56MP0001666_abnormal_nutrient_absorption1.38339942
57MP0004885_abnormal_endolymph1.38287315
58MP0005551_abnormal_eye_electrophysiolog1.36410463
59MP0002163_abnormal_gland_morphology1.35981419
60MP0001502_abnormal_circadian_rhythm1.35660603
61MP0004215_abnormal_myocardial_fiber1.35050777
62MP0002882_abnormal_neuron_morphology1.31908440
63MP0006072_abnormal_retinal_apoptosis1.29817813
64MP0008569_lethality_at_weaning1.28042559
65MP0008877_abnormal_DNA_methylation1.27392763
66* MP0002876_abnormal_thyroid_physiology1.26794418
67MP0001188_hyperpigmentation1.26568732
68MP0003283_abnormal_digestive_organ1.26126312
69MP0005174_abnormal_tail_pigmentation1.25191877
70MP0005448_abnormal_energy_balance1.24773749
71MP0001986_abnormal_taste_sensitivity1.22332339
72MP0005220_abnormal_exocrine_pancreas1.21498156
73MP0002822_catalepsy1.20719906
74MP0004924_abnormal_behavior1.20563907
75MP0005386_behavior/neurological_phenoty1.20563907
76* MP0001299_abnormal_eye_distance/1.19090040
77MP0004811_abnormal_neuron_physiology1.18114903
78MP0004130_abnormal_muscle_cell1.17288025
79MP0003868_abnormal_feces_composition1.16416866
80MP0002229_neurodegeneration1.15476781
81MP0001177_atelectasis1.13416568
82MP0001756_abnormal_urination1.12510191
83MP0003633_abnormal_nervous_system1.12373427
84MP0008872_abnormal_physiological_respon1.11765719
85MP0003879_abnormal_hair_cell1.10310788
86MP0005636_abnormal_mineral_homeostasis1.08830585
87MP0002928_abnormal_bile_duct1.08578079
88MP0003329_amyloid_beta_deposits1.08043262
89* MP0002066_abnormal_motor_capabilities/c1.06902125
90MP0000569_abnormal_digit_pigmentation1.06127727
91MP0003787_abnormal_imprinting1.05476118
92MP0003045_fibrosis1.04007239
93MP0002118_abnormal_lipid_homeostasis1.03425683
94MP0003953_abnormal_hormone_level1.02355989
95MP0002837_dystrophic_cardiac_calcinosis1.01339684
96MP0002971_abnormal_brown_adipose1.00797087
97MP0002277_abnormal_respiratory_mucosa0.96903407
98MP0004742_abnormal_vestibular_system0.96801266
99MP0001765_abnormal_ion_homeostasis0.96148364
100MP0005379_endocrine/exocrine_gland_phen0.94784523
101MP0003136_yellow_coat_color0.94609430
102MP0002138_abnormal_hepatobiliary_system0.93924439
103MP0004085_abnormal_heartbeat0.93603644
104MP0003634_abnormal_glial_cell0.93447100
105MP0003011_delayed_dark_adaptation0.92935130
106MP0003631_nervous_system_phenotype0.92484466
107MP0003122_maternal_imprinting0.92233634
108MP0009643_abnormal_urine_homeostasis0.91687515
109MP0002102_abnormal_ear_morphology0.91631316
110MP0005187_abnormal_penis_morphology0.91499811
111MP0002090_abnormal_vision0.88887740
112MP0004147_increased_porphyrin_level0.88503374
113MP0000631_abnormal_neuroendocrine_gland0.88445580
114MP0005670_abnormal_white_adipose0.86707134
115MP0002752_abnormal_somatic_nervous0.85751196
116MP0001485_abnormal_pinna_reflex0.85297457
117MP0000538_abnormal_urinary_bladder0.83363129
118MP0001905_abnormal_dopamine_level0.83073151
119MP0004133_heterotaxia0.82327352
120MP0009840_abnormal_foam_cell0.82094184
121MP0001944_abnormal_pancreas_morphology0.81743848
122MP0002069_abnormal_eating/drinking_beha0.81638311
123MP0001963_abnormal_hearing_physiology0.81618449
124MP0001664_abnormal_digestion0.80470942
125MP0005253_abnormal_eye_physiology0.80365802
126MP0002152_abnormal_brain_morphology0.80042668
127MP0005171_absent_coat_pigmentation0.79910062
128MP0005310_abnormal_salivary_gland0.79855806
129MP0000751_myopathy0.77097221
130MP0005535_abnormal_body_temperature0.76616092
131MP0004142_abnormal_muscle_tone0.76331529
132MP0002234_abnormal_pharynx_morphology0.76076081
133MP0003632_abnormal_nervous_system0.75095905
134MP0003195_calcinosis0.72890856
135MP0003690_abnormal_glial_cell0.72070883
136MP0002896_abnormal_bone_mineralization0.71620179
137MP0008961_abnormal_basal_metabolism0.70772560
138MP0003137_abnormal_impulse_conducting0.70642339
139MP0005647_abnormal_sex_gland0.69065563
140MP0002693_abnormal_pancreas_physiology0.66986312
141MP0000566_synostosis0.66439009
142MP0005499_abnormal_olfactory_system0.61476382
143MP0005394_taste/olfaction_phenotype0.61476382
144MP0001346_abnormal_lacrimal_gland0.60511086
145MP0001270_distended_abdomen0.60076864

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.42569105
2Atonic seizures (HP:0010819)4.22430483
3Focal seizures (HP:0007359)4.14877605
4Febrile seizures (HP:0002373)4.12823742
5Myokymia (HP:0002411)4.02156988
6Epileptic encephalopathy (HP:0200134)3.54695073
7Absence seizures (HP:0002121)3.33082535
8Ketoacidosis (HP:0001993)3.27966879
9Absent/shortened dynein arms (HP:0200106)3.24856720
10Dynein arm defect of respiratory motile cilia (HP:0012255)3.24856720
11Progressive cerebellar ataxia (HP:0002073)3.20703565
12Visual hallucinations (HP:0002367)3.19929685
13Abnormality of vitamin B metabolism (HP:0004340)3.02751170
14Generalized tonic-clonic seizures (HP:0002069)3.01989839
15Increased circulating renin level (HP:0000848)3.01184331
16Dialeptic seizures (HP:0011146)3.00204769
17Abnormal ciliary motility (HP:0012262)2.96556100
18Large for gestational age (HP:0001520)2.95823349
19Action tremor (HP:0002345)2.94931917
20Pancreatic fibrosis (HP:0100732)2.92610123
21Aplasia involving bones of the upper limbs (HP:0009823)2.89442508
22Aplasia of the phalanges of the hand (HP:0009802)2.89442508
23Aplasia involving bones of the extremities (HP:0009825)2.89442508
24Abnormal respiratory epithelium morphology (HP:0012253)2.87837863
25Abnormal respiratory motile cilium morphology (HP:0005938)2.87837863
26Hyperactive renin-angiotensin system (HP:0000841)2.85389027
27Pancreatic cysts (HP:0001737)2.85274883
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.76944783
29Hypoglycemic coma (HP:0001325)2.71275007
30True hermaphroditism (HP:0010459)2.63630007
31Abnormality of potassium homeostasis (HP:0011042)2.63194951
32Truncal ataxia (HP:0002078)2.63143786
33Supranuclear gaze palsy (HP:0000605)2.61667287
34Rhinitis (HP:0012384)2.60844385
35Abnormality of vitamin metabolism (HP:0100508)2.59737968
36Agitation (HP:0000713)2.58440628
37Fetal akinesia sequence (HP:0001989)2.57990221
38Hyperglycemia (HP:0003074)2.57278730
39Gaze-evoked nystagmus (HP:0000640)2.57267908
40Congenital sensorineural hearing impairment (HP:0008527)2.55317949
41Hyperinsulinemic hypoglycemia (HP:0000825)2.54313444
42Nephronophthisis (HP:0000090)2.54252603
43Abnormality of renin-angiotensin system (HP:0000847)2.51915064
44Ketosis (HP:0001946)2.50902379
45Tubulointerstitial nephritis (HP:0001970)2.50679530
46Abnormality of the renal cortex (HP:0011035)2.49804053
47Ankle clonus (HP:0011448)2.47661273
48Hypobetalipoproteinemia (HP:0003563)2.46711298
49Hyperventilation (HP:0002883)2.42727789
50Hypoglycemic seizures (HP:0002173)2.42232515
51Abnormality of proline metabolism (HP:0010907)2.42229812
52Hydroxyprolinuria (HP:0003080)2.42229812
53Dysdiadochokinesis (HP:0002075)2.41496293
54Pheochromocytoma (HP:0002666)2.38098770
55Molar tooth sign on MRI (HP:0002419)2.36991723
56Abnormality of midbrain morphology (HP:0002418)2.36991723
57Abnormality of glutamine family amino acid metabolism (HP:0010902)2.35931910
58Broad-based gait (HP:0002136)2.32696901
59Dysmetria (HP:0001310)2.31240645
60Abnormality of the vitamin B12 metabolism (HP:0004341)2.29913399
61Epileptiform EEG discharges (HP:0011182)2.29346999
62Muscle hypertrophy of the lower extremities (HP:0008968)2.29325683
63Proximal tubulopathy (HP:0000114)2.28087930
64Insulin-resistant diabetes mellitus (HP:0000831)2.27369943
65Abnormality of the renal medulla (HP:0100957)2.27027782
66Impaired vibration sensation in the lower limbs (HP:0002166)2.26329657
67Hyperaldosteronism (HP:0000859)2.26118499
68Furrowed tongue (HP:0000221)2.25758886
69Cystic liver disease (HP:0006706)2.24837753
70Insidious onset (HP:0003587)2.24761586
71Termporal pattern (HP:0011008)2.24761586
72Calf muscle hypertrophy (HP:0008981)2.24513775
73Abnormality of aromatic amino acid family metabolism (HP:0004338)2.24483454
74Vascular calcification (HP:0004934)2.22897063
75Excessive salivation (HP:0003781)2.20848640
76Drooling (HP:0002307)2.20848640
77Exotropia (HP:0000577)2.20718380
78Intention tremor (HP:0002080)2.19736696
79EEG with generalized epileptiform discharges (HP:0011198)2.19392677
80Muscle fiber inclusion bodies (HP:0100299)2.18655852
81Nemaline bodies (HP:0003798)2.18468245
82Blue irides (HP:0000635)2.17913258
83Postural instability (HP:0002172)2.16131510
84Depression (HP:0000716)2.16084312
85Abnormality of the corticospinal tract (HP:0002492)2.15010403
86Methylmalonic acidemia (HP:0002912)2.13366035
87Ventricular fibrillation (HP:0001663)2.12864525
88Hematochezia (HP:0002573)2.12413453
89Scanning speech (HP:0002168)2.07632502
90Chronic hepatic failure (HP:0100626)2.07592689
91Renal cortical cysts (HP:0000803)2.06815491
92Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.06694133
93Fair hair (HP:0002286)2.06473424
94Hyperphosphatemia (HP:0002905)2.06452212
95Hypothermia (HP:0002045)2.06230613
96Tubular atrophy (HP:0000092)2.02704007
97Intestinal atresia (HP:0011100)2.02475353
98Bronchiectasis (HP:0002110)2.01822051
99Bundle branch block (HP:0011710)2.00208973
100Hypsarrhythmia (HP:0002521)1.99810832
101Hypokalemia (HP:0002900)1.99313061
102Papillary thyroid carcinoma (HP:0002895)1.98748223
103Retinal dysplasia (HP:0007973)1.97631988
104Bradycardia (HP:0001662)1.97596025
105Generalized hypopigmentation of hair (HP:0011358)1.96628264
106Congenital stationary night blindness (HP:0007642)1.96494069
107Urinary bladder sphincter dysfunction (HP:0002839)1.96135457
108Neuroendocrine neoplasm (HP:0100634)1.95691743
109Anxiety (HP:0000739)1.95626457
110Degeneration of the lateral corticospinal tracts (HP:0002314)1.92600398
111Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92600398
112Hypomagnesemia (HP:0002917)1.90719078
113Abnormality of calcium-phosphate metabolism (HP:0100530)1.90181413
114Amblyopia (HP:0000646)1.89927111
115Potter facies (HP:0002009)1.89134571
116Facial shape deformation (HP:0011334)1.89134571
117Nephrogenic diabetes insipidus (HP:0009806)1.88211500
118Neurofibrillary tangles (HP:0002185)1.86102710
119Cutaneous finger syndactyly (HP:0010554)1.85350112
120Abnormality of chloride homeostasis (HP:0011422)1.84591015
121Hyperkalemia (HP:0002153)1.84137166
122Prolonged QT interval (HP:0001657)1.83391853
123Spastic gait (HP:0002064)1.83037583
124Failure to thrive in infancy (HP:0001531)1.82992158
125Cardiovascular calcification (HP:0011915)1.82538879
126Abnormal drinking behavior (HP:0030082)1.81464189
127Polydipsia (HP:0001959)1.81464189
128Gait imbalance (HP:0002141)1.81121668
129Genetic anticipation (HP:0003743)1.81064127
130Aplasia/Hypoplasia of the fovea (HP:0008060)1.80835851
131Hypoplasia of the fovea (HP:0007750)1.80835851
132Widely spaced teeth (HP:0000687)1.80720277
133Hypoventilation (HP:0002791)1.80311062
134Exercise-induced myalgia (HP:0003738)1.78353517
135Abnormality of the calf musculature (HP:0001430)1.78167316
136Absent speech (HP:0001344)1.77586303
137Impaired smooth pursuit (HP:0007772)1.77295916
138Central scotoma (HP:0000603)1.76788715
139Labial hypoplasia (HP:0000066)1.76586990
140Hyperlipoproteinemia (HP:0010980)1.76501857
141Albinism (HP:0001022)1.75935629
142Cerebral inclusion bodies (HP:0100314)1.75908166
143Hyperthyroidism (HP:0000836)1.75781147
144Macroorchidism (HP:0000053)1.75651540
145Abnormal eating behavior (HP:0100738)1.75290542
146Anosmia (HP:0000458)1.75065908
147Congenital hepatic fibrosis (HP:0002612)1.74399419
148Papilledema (HP:0001085)1.74399089
149Ulnar claw (HP:0001178)1.74170005
150Late onset (HP:0003584)1.73511732
151Genital tract atresia (HP:0001827)1.71574196
152Hemiplegia (HP:0002301)1.69856779
153Lower limb muscle weakness (HP:0007340)1.69320543
154Progressive inability to walk (HP:0002505)1.68311091
155Hyporeflexia of lower limbs (HP:0002600)1.68307660
156Vaginal atresia (HP:0000148)1.68051113
157Medial flaring of the eyebrow (HP:0010747)1.66645246
158Abnormality of salivation (HP:0100755)1.65798575
159Hypoplastic nipples (HP:0002557)1.64699433
160Syncope (HP:0001279)1.64346165
161Protruding tongue (HP:0010808)1.63095472
162Abnormality of macular pigmentation (HP:0008002)1.63027311
163Decreased circulating renin level (HP:0003351)1.62874775
164Abnormal respiratory motile cilium physiology (HP:0012261)1.62533499
165Akinesia (HP:0002304)1.62126109
166Absent eyebrow (HP:0002223)1.61951334
167Aqueductal stenosis (HP:0002410)1.61765724
168Gait ataxia (HP:0002066)1.58292796
169Hemiparesis (HP:0001269)1.58133066
170Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.57084017
171Aplasia/Hypoplasia of the brainstem (HP:0007362)1.57000533
172Hypoplasia of the brainstem (HP:0002365)1.57000533
173Status epilepticus (HP:0002133)1.56730770
174Congenital primary aphakia (HP:0007707)1.56403079
175Bradykinesia (HP:0002067)1.55988323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.86774737
2OBSCN2.98960891
3AKT32.97742262
4ACVR1B2.75250300
5CASK2.56713225
6INSRR2.49141434
7MAP3K22.46301433
8MAP3K42.45473093
9FRK2.37124029
10EPHA42.29894837
11MAP2K72.11891994
12NTRK12.09960502
13STK392.06340143
14MAP3K92.04500140
15MARK11.96282591
16MAP2K61.94827637
17GRK11.87949981
18NLK1.85390435
19CAMKK21.80674608
20LATS11.73293173
21MINK11.64772225
22PIK3CG1.63976079
23DAPK21.62381688
24MAP4K21.58471423
25OXSR11.57470621
26MAP2K41.55812481
27TRPM71.55671806
28PRKD31.53107324
29ADRBK21.51455395
30FGFR31.50284540
31NTRK21.43476517
32TNIK1.38388405
33CAMKK11.37963402
34WNK11.31880341
35PAK61.31475312
36FER1.31433093
37TAOK31.28974195
38GRK51.27515702
39SGK21.26596726
40SGK2231.24043526
41SGK4941.24043526
42PRPF4B1.23375248
43PHKG11.22936159
44PHKG21.22936159
45MAPK151.22268943
46LMTK21.20790547
47PRKAA21.17607237
48MAPK131.16235867
49EPHA31.15684991
50CDK51.15343244
51MUSK1.14971173
52MAPKAPK31.14465179
53PAK31.08238531
54WNK41.05236868
55STK241.03433593
56PRKCG1.03269947
57KSR21.02761689
58CAMK2B1.01775700
59CAMK2A0.99178056
60PRKCE0.98806348
61FGFR20.98656773
62TNK20.96824357
63STK380.95288311
64IRAK10.94628738
65STK38L0.94073563
66SGK30.92781933
67PIK3CA0.91580597
68PLK20.90241981
69PTK2B0.89897754
70RET0.89675545
71CAMK2D0.89388153
72PRKCH0.86946134
73PINK10.86904605
74CDC42BPA0.78197983
75WNK30.77815459
76NEK60.77792511
77MARK20.75335533
78NUAK10.71965651
79PDGFRA0.71649579
80BCR0.71223950
81RIPK40.70352830
82SGK10.69965987
83MAP3K10.69196026
84MAP3K120.68042710
85CAMK2G0.66664898
86KSR10.66553982
87LATS20.66478738
88UHMK10.66265420
89JAK10.65649658
90STK30.65218031
91ERBB30.64449215
92MST40.64282177
93HIPK20.63947897
94RPS6KA20.62066512
95STK110.61061649
96BMPR20.59150803
97PDK20.58394947
98CAMK1G0.57820218
99CSNK1G20.57423613
100PNCK0.57388704
101CDK30.55641342
102MAPK110.55091105
103DAPK10.51377280
104DYRK1A0.50897098
105SCYL20.50815096
106CSNK1G10.49789408
107PDPK10.49509786
108CAMK10.49343306
109MKNK20.48455933
110ADRBK10.47465302
111DDR20.45921905
112MAP2K10.45360941
113RPS6KA30.44832886
114EIF2AK30.44485078
115PRKD20.44453344
116MAPK120.44146068
117BMPR1B0.43337717
118PDK40.43088135
119PDK30.43088135
120TLK10.41936857
121CHUK0.41024663
122PRKCQ0.39733523
123PRKCZ0.39460800
124MAPK70.39050524
125PRKAA10.38953856
126MAP3K70.38864713
127PRKG10.38028997
128PRKACA0.37780723
129PDK10.37316059
130PRKACB0.35900718
131CSNK1D0.33726861
132PRKCI0.32835979
133PRKCA0.32454949
134CSNK1G30.31884664
135PRKACG0.31407047

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.88678605
2Synaptic vesicle cycle_Homo sapiens_hsa047212.63357467
3Olfactory transduction_Homo sapiens_hsa047402.60133322
4Butanoate metabolism_Homo sapiens_hsa006502.36960497
5Insulin secretion_Homo sapiens_hsa049112.26508214
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.18035182
7GABAergic synapse_Homo sapiens_hsa047272.15271864
8Circadian entrainment_Homo sapiens_hsa047132.14965649
9Glutamatergic synapse_Homo sapiens_hsa047242.10970943
10Long-term potentiation_Homo sapiens_hsa047202.08697524
11Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08171778
12Taste transduction_Homo sapiens_hsa047422.06741729
13Amphetamine addiction_Homo sapiens_hsa050312.05967162
14Morphine addiction_Homo sapiens_hsa050322.04575963
15Linoleic acid metabolism_Homo sapiens_hsa005911.98481786
16Caffeine metabolism_Homo sapiens_hsa002321.91500550
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85844398
18Tryptophan metabolism_Homo sapiens_hsa003801.85764056
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78978851
20Chemical carcinogenesis_Homo sapiens_hsa052041.78270575
21Salivary secretion_Homo sapiens_hsa049701.78225482
22Dopaminergic synapse_Homo sapiens_hsa047281.77185677
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73876250
24Histidine metabolism_Homo sapiens_hsa003401.68064323
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.66347466
26Retinol metabolism_Homo sapiens_hsa008301.63691452
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63508878
28* ABC transporters_Homo sapiens_hsa020101.62371537
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.59833593
30Serotonergic synapse_Homo sapiens_hsa047261.59682426
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59002528
32Collecting duct acid secretion_Homo sapiens_hsa049661.56955102
33Gastric acid secretion_Homo sapiens_hsa049711.54576879
34Vibrio cholerae infection_Homo sapiens_hsa051101.54515027
35Fatty acid degradation_Homo sapiens_hsa000711.54042589
36Cholinergic synapse_Homo sapiens_hsa047251.53602028
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.53591842
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52191690
39Renin secretion_Homo sapiens_hsa049241.50473015
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.45702149
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45630320
42alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43645660
43Cocaine addiction_Homo sapiens_hsa050301.42950781
44Propanoate metabolism_Homo sapiens_hsa006401.33920452
45Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33718310
46Phototransduction_Homo sapiens_hsa047441.32561736
47Type II diabetes mellitus_Homo sapiens_hsa049301.28503686
48Sulfur metabolism_Homo sapiens_hsa009201.28485731
49Calcium signaling pathway_Homo sapiens_hsa040201.27646988
50Long-term depression_Homo sapiens_hsa047301.27509760
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24837127
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.24159622
53Oxytocin signaling pathway_Homo sapiens_hsa049211.22650805
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22452668
55beta-Alanine metabolism_Homo sapiens_hsa004101.18568551
56Peroxisome_Homo sapiens_hsa041461.18480920
57Starch and sucrose metabolism_Homo sapiens_hsa005001.17727805
58Fat digestion and absorption_Homo sapiens_hsa049751.15797761
59Arginine biosynthesis_Homo sapiens_hsa002201.13652390
60Vitamin digestion and absorption_Homo sapiens_hsa049771.12043260
61cAMP signaling pathway_Homo sapiens_hsa040241.11411968
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.11069077
63Pancreatic secretion_Homo sapiens_hsa049721.10913797
64Thyroid hormone synthesis_Homo sapiens_hsa049181.10519002
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10264676
66GnRH signaling pathway_Homo sapiens_hsa049121.10081356
67Gap junction_Homo sapiens_hsa045401.04066422
68Vascular smooth muscle contraction_Homo sapiens_hsa042701.03699444
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.02490429
70cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01723733
71Estrogen signaling pathway_Homo sapiens_hsa049150.98613683
72Dorso-ventral axis formation_Homo sapiens_hsa043200.98340078
73Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97195603
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96061092
75Circadian rhythm_Homo sapiens_hsa047100.95909053
76Axon guidance_Homo sapiens_hsa043600.95780320
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.91023934
78Complement and coagulation cascades_Homo sapiens_hsa046100.90832375
79PPAR signaling pathway_Homo sapiens_hsa033200.90631454
80ErbB signaling pathway_Homo sapiens_hsa040120.88266318
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87506002
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.85057480
83Melanogenesis_Homo sapiens_hsa049160.84718173
84Fatty acid metabolism_Homo sapiens_hsa012120.80384605
85Arachidonic acid metabolism_Homo sapiens_hsa005900.79710827
86Glioma_Homo sapiens_hsa052140.79436626
87Insulin resistance_Homo sapiens_hsa049310.77012126
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76892654
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74912757
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74152273
91Dilated cardiomyopathy_Homo sapiens_hsa054140.73053924
92Tyrosine metabolism_Homo sapiens_hsa003500.72751390
93Glycerolipid metabolism_Homo sapiens_hsa005610.72342834
94Inositol phosphate metabolism_Homo sapiens_hsa005620.72075897
95Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70357157
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70356364
97Glucagon signaling pathway_Homo sapiens_hsa049220.70103323
98Selenocompound metabolism_Homo sapiens_hsa004500.66838038
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65167150
100Sphingolipid metabolism_Homo sapiens_hsa006000.65096454
101Choline metabolism in cancer_Homo sapiens_hsa052310.63527098
102Ovarian steroidogenesis_Homo sapiens_hsa049130.62096275
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.60881291
104Bile secretion_Homo sapiens_hsa049760.58110892
105Ras signaling pathway_Homo sapiens_hsa040140.58039651
106Cardiac muscle contraction_Homo sapiens_hsa042600.57855017
107MAPK signaling pathway_Homo sapiens_hsa040100.57415477
108Tight junction_Homo sapiens_hsa045300.56485839
109Phenylalanine metabolism_Homo sapiens_hsa003600.56101071
110Folate biosynthesis_Homo sapiens_hsa007900.54995673
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54472049
112Protein export_Homo sapiens_hsa030600.54284705
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51905650
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51772051
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.49588469
116Arginine and proline metabolism_Homo sapiens_hsa003300.49120321
117Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48812719
118Endometrial cancer_Homo sapiens_hsa052130.47927051
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.47283007
120Fatty acid biosynthesis_Homo sapiens_hsa000610.47088841
121Mineral absorption_Homo sapiens_hsa049780.45648800
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45120251
123mTOR signaling pathway_Homo sapiens_hsa041500.45039122
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44876150
125Insulin signaling pathway_Homo sapiens_hsa049100.44740515
126Wnt signaling pathway_Homo sapiens_hsa043100.44665396
127Rap1 signaling pathway_Homo sapiens_hsa040150.43855235
128N-Glycan biosynthesis_Homo sapiens_hsa005100.43826363
129Melanoma_Homo sapiens_hsa052180.41359483
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40003725
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.39138685
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38447030
133Type I diabetes mellitus_Homo sapiens_hsa049400.37612017
134Regulation of autophagy_Homo sapiens_hsa041400.37435631
135Endocytosis_Homo sapiens_hsa041440.37004650
136Protein digestion and absorption_Homo sapiens_hsa049740.36695834
137Prion diseases_Homo sapiens_hsa050200.35383952
138Ether lipid metabolism_Homo sapiens_hsa005650.34862808
139Alcoholism_Homo sapiens_hsa050340.33979181
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33459287
141Nitrogen metabolism_Homo sapiens_hsa009100.31782380

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