ABCA6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This gene is clustered among 4 other ABC1 family members on 17q24 and may play a role in macrophage lipid homeostasis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.40895681
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.40895681
3exogenous drug catabolic process (GO:0042738)7.26688634
4L-phenylalanine metabolic process (GO:0006558)7.07419649
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.07419649
6aromatic amino acid family catabolic process (GO:0009074)6.73214314
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.22304270
8tryptophan catabolic process (GO:0006569)6.12774752
9indole-containing compound catabolic process (GO:0042436)6.12774752
10indolalkylamine catabolic process (GO:0046218)6.12774752
11omega-hydroxylase P450 pathway (GO:0097267)6.10437809
12kynurenine metabolic process (GO:0070189)6.01312383
13bile acid biosynthetic process (GO:0006699)5.99370729
14epoxygenase P450 pathway (GO:0019373)5.83249376
15tryptophan metabolic process (GO:0006568)5.76911752
16urea cycle (GO:0000050)5.71112851
17urea metabolic process (GO:0019627)5.71112851
18alpha-linolenic acid metabolic process (GO:0036109)5.66996123
19glyoxylate metabolic process (GO:0046487)5.63569695
20negative regulation of fibrinolysis (GO:0051918)5.59602800
21complement activation, alternative pathway (GO:0006957)5.51114272
22regulation of protein activation cascade (GO:2000257)5.50209186
23high-density lipoprotein particle remodeling (GO:0034375)5.47862631
24regulation of fibrinolysis (GO:0051917)5.41117237
25peptidyl-glutamic acid carboxylation (GO:0017187)5.37570514
26protein carboxylation (GO:0018214)5.37570514
27nitrogen cycle metabolic process (GO:0071941)5.24352420
28cysteine metabolic process (GO:0006534)5.17506769
29sulfur amino acid catabolic process (GO:0000098)5.15739316
30regulation of complement activation (GO:0030449)5.14755099
31bile acid metabolic process (GO:0008206)5.11899282
32serine family amino acid catabolic process (GO:0009071)4.98844330
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97412616
34aromatic amino acid family metabolic process (GO:0009072)4.89167914
35homocysteine metabolic process (GO:0050667)4.87260145
36regulation of cholesterol esterification (GO:0010872)4.86295204
37oxidative demethylation (GO:0070989)4.83186966
38regulation of triglyceride catabolic process (GO:0010896)4.81226891
39plasma lipoprotein particle remodeling (GO:0034369)4.78402988
40protein-lipid complex remodeling (GO:0034368)4.78402988
41macromolecular complex remodeling (GO:0034367)4.78402988
42reverse cholesterol transport (GO:0043691)4.77030934
43tyrosine metabolic process (GO:0006570)4.73700165
44amino-acid betaine metabolic process (GO:0006577)4.59377986
45alpha-amino acid catabolic process (GO:1901606)4.58729109
46phospholipid efflux (GO:0033700)4.58001560
47lysine catabolic process (GO:0006554)4.56509420
48lysine metabolic process (GO:0006553)4.56509420
49triglyceride homeostasis (GO:0070328)4.53588937
50acylglycerol homeostasis (GO:0055090)4.53588937
51negative regulation of cholesterol transport (GO:0032375)4.51722887
52negative regulation of sterol transport (GO:0032372)4.51722887
53drug metabolic process (GO:0017144)4.48300183
54plasma lipoprotein particle clearance (GO:0034381)4.43974501
55bile acid and bile salt transport (GO:0015721)4.43723432
56indolalkylamine metabolic process (GO:0006586)4.33835701
57coenzyme catabolic process (GO:0009109)4.32372193
58cellular ketone body metabolic process (GO:0046950)4.31265557
59cholesterol efflux (GO:0033344)4.29030766
60glycine metabolic process (GO:0006544)4.28666746
61cellular glucuronidation (GO:0052695)4.26851713
62amine catabolic process (GO:0009310)4.25527079
63cellular biogenic amine catabolic process (GO:0042402)4.25527079
64imidazole-containing compound metabolic process (GO:0052803)4.24980645
65cellular amino acid catabolic process (GO:0009063)4.20882994
66glutamate metabolic process (GO:0006536)4.16019709
67benzene-containing compound metabolic process (GO:0042537)4.14661301
68low-density lipoprotein particle remodeling (GO:0034374)4.12472650
69negative regulation of complement activation (GO:0045916)4.06878678
70plasma lipoprotein particle assembly (GO:0034377)4.06377480
71ethanol oxidation (GO:0006069)4.05541154
72serine family amino acid metabolic process (GO:0009069)4.05446672
73fibrinolysis (GO:0042730)4.04967492
74dicarboxylic acid biosynthetic process (GO:0043650)4.02217410
75cellular modified amino acid catabolic process (GO:0042219)3.95490100
76arginine metabolic process (GO:0006525)3.92552346
77very-low-density lipoprotein particle assembly (GO:0034379)3.92483542
78blood coagulation, intrinsic pathway (GO:0007597)3.86216460
79aldehyde catabolic process (GO:0046185)3.86178909
80drug catabolic process (GO:0042737)3.86100994
81positive regulation of lipid catabolic process (GO:0050996)3.86080572
82serine family amino acid biosynthetic process (GO:0009070)3.85985898
83phospholipid homeostasis (GO:0055091)3.82615248
84complement activation, classical pathway (GO:0006958)3.80852313
85complement activation (GO:0006956)3.79551654
86uronic acid metabolic process (GO:0006063)3.78086807
87glucuronate metabolic process (GO:0019585)3.78086807
88cofactor catabolic process (GO:0051187)3.76059766
89protein activation cascade (GO:0072376)3.75951995
90negative regulation of lipase activity (GO:0060192)3.74534926
91ketone body metabolic process (GO:1902224)3.73241547
92cholesterol homeostasis (GO:0042632)3.72992524
93regulation of bile acid biosynthetic process (GO:0070857)3.71029438
94acetyl-CoA metabolic process (GO:0006084)3.70897065
95organic acid catabolic process (GO:0016054)3.70182200
96carboxylic acid catabolic process (GO:0046395)3.70182200
97cytolysis (GO:0019835)3.69938968
98positive regulation of lipoprotein lipase activity (GO:0051006)3.69787743
99positive regulation of triglyceride lipase activity (GO:0061365)3.69787743
100heme transport (GO:0015886)3.68374080
101sterol homeostasis (GO:0055092)3.66641836
102negative regulation of protein activation cascade (GO:2000258)3.66406234
103positive regulation of fatty acid beta-oxidation (GO:0032000)3.66127106
104protein-lipid complex assembly (GO:0065005)3.64522107
105short-chain fatty acid metabolic process (GO:0046459)3.64174292
106plasma lipoprotein particle organization (GO:0071827)3.63882227
107ethanol metabolic process (GO:0006067)3.62785069
108S-adenosylmethionine metabolic process (GO:0046500)3.60358512
109flavonoid metabolic process (GO:0009812)3.54034425
110opsonization (GO:0008228)3.46831497
111phenylpropanoid metabolic process (GO:0009698)3.39594801
112regulation of humoral immune response (GO:0002920)3.37379262
113fatty acid transmembrane transport (GO:1902001)3.27647731
114alkaloid metabolic process (GO:0009820)3.09957715
115negative regulation of humoral immune response (GO:0002921)3.06521572
116negative regulation of hemostasis (GO:1900047)2.95690767
117negative regulation of blood coagulation (GO:0030195)2.95690767
118xenobiotic catabolic process (GO:0042178)2.91594143
119regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.81065546
120arginine catabolic process (GO:0006527)2.80035372
121xenobiotic metabolic process (GO:0006805)2.79668636
122regulation of plasminogen activation (GO:0010755)2.76302575
123negative regulation of coagulation (GO:0050819)2.71504304
124acute-phase response (GO:0006953)2.71261554
125sodium-independent organic anion transport (GO:0043252)2.69997765
126positive regulation of glycolytic process (GO:0045821)2.64590522
127negative regulation of wound healing (GO:0061045)2.64467973
128cellular response to ethanol (GO:0071361)2.64419858
129amino acid salvage (GO:0043102)2.63899105
130L-methionine salvage (GO:0071267)2.63899105
131L-methionine biosynthetic process (GO:0071265)2.63899105
132hormone catabolic process (GO:0042447)2.57754842
133dopamine transport (GO:0015872)2.57391037
134regulation of sarcomere organization (GO:0060297)2.55638836
135positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.55412598
136drug transmembrane transport (GO:0006855)2.52762777
137regulation of lipoprotein metabolic process (GO:0050746)2.52055941
138indole-containing compound metabolic process (GO:0042430)2.51407492
139regulation of sequestering of triglyceride (GO:0010889)2.50924769
140positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.48986756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.20828375
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.03457465
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.98083881
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.46043897
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.24930553
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.98345846
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76996789
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.11514386
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.88744860
10GBX2_23144817_ChIP-Seq_PC3_Human3.14070292
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.26391597
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24514603
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23265750
14EZH2_22144423_ChIP-Seq_EOC_Human2.11568841
15VDR_22108803_ChIP-Seq_LS180_Human2.10756400
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.04751750
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7119581
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95771552
19CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91965822
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87467966
21HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86221542
22IGF1R_20145208_ChIP-Seq_DFB_Human1.80276010
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.77478369
24SMAD4_21799915_ChIP-Seq_A2780_Human1.68759981
25STAT3_23295773_ChIP-Seq_U87_Human1.68399634
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67787647
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.66924469
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66862324
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.66054020
30ER_23166858_ChIP-Seq_MCF-7_Human1.64967738
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64368880
32HTT_18923047_ChIP-ChIP_STHdh_Human1.61769580
33P300_19829295_ChIP-Seq_ESCs_Human1.58656749
34CLOCK_20551151_ChIP-Seq_293T_Human1.56769297
35SUZ12_27294783_Chip-Seq_NPCs_Mouse1.53531669
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.52209128
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51942785
38TCF4_23295773_ChIP-Seq_U87_Human1.51753078
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50548587
40GATA1_22025678_ChIP-Seq_K562_Human1.48261544
41ZNF274_21170338_ChIP-Seq_K562_Hela1.46538164
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45075767
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44393900
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43253346
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.43174958
46HNF4A_19822575_ChIP-Seq_HepG2_Human1.40210722
47SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36787526
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35907842
49TP53_16413492_ChIP-PET_HCT116_Human1.35872280
50AR_25329375_ChIP-Seq_VCAP_Human1.34890761
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33635442
52CBP_20019798_ChIP-Seq_JUKART_Human1.33635442
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.32200721
54CJUN_26792858_Chip-Seq_BT549_Human1.32127316
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30850089
56AHR_22903824_ChIP-Seq_MCF-7_Human1.27256006
57* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25833666
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25122092
59CRX_20693478_ChIP-Seq_RETINA_Mouse1.23782389
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.23144932
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22941886
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22304933
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21637831
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21576212
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21230075
66ARNT_22903824_ChIP-Seq_MCF-7_Human1.17828759
67OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17468534
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16960694
69CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16516122
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.15457032
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15266695
72* FUS_26573619_Chip-Seq_HEK293_Human1.15164334
73* TCF4_22108803_ChIP-Seq_LS180_Human1.14891865
74RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14621797
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.14520138
76AR_21572438_ChIP-Seq_LNCaP_Human1.14196047
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13151139
78POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13151139
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13148159
80TP53_18474530_ChIP-ChIP_U2OS_Human1.12377269
81RUNX2_22187159_ChIP-Seq_PCA_Human1.11583742
82P53_22387025_ChIP-Seq_ESCs_Mouse1.11451603
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.09648448
84DROSHA_22980978_ChIP-Seq_HELA_Human1.08973270
85* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08016281
86STAT3_18555785_Chip-Seq_ESCs_Mouse1.05182406
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04725361
88NANOG_19829295_ChIP-Seq_ESCs_Human1.04701887
89SOX2_19829295_ChIP-Seq_ESCs_Human1.04701887
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04438519
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03924429
92SMAD4_21741376_ChIP-Seq_EPCs_Human1.03876015
93SOX2_21211035_ChIP-Seq_LN229_Gbm1.03077881
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02764567
95* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00806657
96ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00506968
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00415614
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99593886
99SUZ12_18555785_Chip-Seq_ESCs_Mouse0.99307115
100ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91581190
101SOX2_27498859_Chip-Seq_STOMACH_Mouse0.90463538
102PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.90458066
103AUTS2_25519132_ChIP-Seq_293T-REX_Human0.85880514
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.85319354
105* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84377166
106IRF8_22096565_ChIP-ChIP_GC-B_Human0.82853420
107Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81502865
108ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.79894697
109GATA4_25053715_ChIP-Seq_YYC3_Human0.78977357
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78315965
111NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78315965
112CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.76392224
113KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75397331
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75240627
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.75009796
116SALL4_18804426_ChIP-ChIP_XEN_Mouse0.74226032
117SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.72578228
118TAF15_26573619_Chip-Seq_HEK293_Human0.72418636
119AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.72161523
120ZNF263_19887448_ChIP-Seq_K562_Human0.68875054
121* RARA_24833708_ChIP-Seq_LIVER_Mouse0.66563287
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.64757919
123RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61804838
124RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59177019
125EGR1_19032775_ChIP-ChIP_M12_Human0.57359133
126RARB_24833708_ChIP-Seq_LIVER_Mouse0.56539939
127FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55396211
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55370421
129FOXA1_25552417_ChIP-Seq_VCAP_Human0.55226684
130BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54832157
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.54058226
132BCAT_22108803_ChIP-Seq_LS180_Human0.53866066
133* CEBPB_22108803_ChIP-Seq_LS180_Human0.53426305
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.53282660
135NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.52882846
136NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.52182197
137ESR1_21235772_ChIP-Seq_MCF-7_Human0.51949077
138AR_20517297_ChIP-Seq_VCAP_Human0.51542297
139MYC_19915707_ChIP-ChIP_AK7_Human0.50836435
140CBP_21632823_ChIP-Seq_H3396_Human0.50621742
141ESR1_20079471_ChIP-ChIP_T-47D_Human0.50166308
142PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49851890
143STAT1_17558387_ChIP-Seq_HELA_Human0.49717497
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.49457868
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.48618594
146* ESET_19884257_ChIP-Seq_ESCs_Mouse0.48045966
147FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.47373679
148ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.46112535
149FOXO3_23340844_ChIP-Seq_DLD1_Human0.45953348
150CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45342908
151LXR_22292898_ChIP-Seq_THP-1_Human0.45301530
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.44777517
153CDX2_20551321_ChIP-Seq_CACO-2_Human0.43848498
154* P53_21459846_ChIP-Seq_SAOS-2_Human0.42950953
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.42594048
156PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42500348
157GATA1_19941826_ChIP-Seq_K562_Human0.41495121
158* GATA2_19941826_ChIP-Seq_K562_Human0.41086422
159STAT3_1855785_ChIP-Seq_MESCs_Mouse0.40685353
160AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.40548392
161SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40121041
162GATA1_19941827_ChIP-Seq_MEL_Mouse0.39903515
163EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.39170018
164TAF2_19829295_ChIP-Seq_ESCs_Human0.38803691
165FOXH1_21741376_ChIP-Seq_EPCs_Human0.38386946
166* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.38371264
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.37960074
168* CDX2_22108803_ChIP-Seq_LS180_Human0.37264206
169STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37033653
170SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36989226
171LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35840751
172SOX2_20726797_ChIP-Seq_SW620_Human0.35748419
173MYC_27129775_Chip-Seq_CORNEA_Mouse0.35137884

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.33969376
2MP0005360_urolithiasis7.51340313
3MP0005085_abnormal_gallbladder_physiolo6.52154968
4MP0005365_abnormal_bile_salt6.26775853
5MP0008875_abnormal_xenobiotic_pharmacok5.07639808
6MP0003806_abnormal_nucleotide_metabolis4.21035918
7MP0003252_abnormal_bile_duct3.98926495
8MP0010329_abnormal_lipoprotein_level3.58776511
9MP0009840_abnormal_foam_cell3.14898922
10MP0005083_abnormal_biliary_tract3.12787657
11MP0003646_muscle_fatigue3.06451586
12MP0003195_calcinosis2.78890542
13MP0005332_abnormal_amino_acid2.72000472
14MP0001666_abnormal_nutrient_absorption2.56802887
15MP0005275_abnormal_skin_tensile2.37869370
16MP0003191_abnormal_cellular_cholesterol2.18750383
17MP0000609_abnormal_liver_physiology2.16525950
18MP0005503_abnormal_tendon_morphology2.13590085
19MP0002118_abnormal_lipid_homeostasis2.11326639
20MP0004019_abnormal_vitamin_homeostasis2.07066762
21MP0002138_abnormal_hepatobiliary_system2.02643016
22MP0008438_abnormal_cutaneous_collagen1.96378142
23MP0003868_abnormal_feces_composition1.92335590
24MP0004145_abnormal_muscle_electrophysio1.82598484
25MP0005319_abnormal_enzyme/_coenzyme1.80941378
26MP0003045_fibrosis1.70944809
27MP0000569_abnormal_digit_pigmentation1.70853706
28MP0009697_abnormal_copulation1.68186779
29MP0004215_abnormal_myocardial_fiber1.67152047
30MP0001764_abnormal_homeostasis1.65492241
31MP0004084_abnormal_cardiac_muscle1.58020538
32MP0000751_myopathy1.54479704
33MP0003950_abnormal_plasma_membrane1.54247731
34MP0005584_abnormal_enzyme/coenzyme_acti1.53501357
35MP0004036_abnormal_muscle_relaxation1.53449062
36MP0001501_abnormal_sleep_pattern1.43939429
37MP0003011_delayed_dark_adaptation1.36632758
38MP0005451_abnormal_body_composition1.33010078
39MP0005551_abnormal_eye_electrophysiolog1.27098390
40MP0002332_abnormal_exercise_endurance1.25126513
41MP0005167_abnormal_blood-brain_barrier1.25094145
42MP0003656_abnormal_erythrocyte_physiolo1.22070957
43MP0004272_abnormal_basement_membrane1.21537119
44MP0009643_abnormal_urine_homeostasis1.19058512
45MP0003186_abnormal_redox_activity1.18216331
46MP0000598_abnormal_liver_morphology1.15843346
47MP0003705_abnormal_hypodermis_morpholog1.15374922
48MP0008775_abnormal_heart_ventricle1.14413819
49MP0005647_abnormal_sex_gland1.14324785
50MP0000013_abnormal_adipose_tissue1.14282519
51MP0000604_amyloidosis1.07858718
52MP0004484_altered_response_of1.07618252
53MP0002108_abnormal_muscle_morphology1.07300335
54MP0008004_abnormal_stomach_pH1.06821170
55MP0009764_decreased_sensitivity_to1.06522301
56MP0010386_abnormal_urinary_bladder1.04373534
57MP0002254_reproductive_system_inflammat1.02439188
58MP0009763_increased_sensitivity_to1.01679499
59MP0010368_abnormal_lymphatic_system1.00064356
60MP0009046_muscle_twitch0.98531170
61MP0005595_abnormal_vascular_smooth0.98006627
62MP0002295_abnormal_pulmonary_circulatio0.95643767
63MP0005670_abnormal_white_adipose0.94521082
64MP0009780_abnormal_chondrocyte_physiolo0.94195353
65MP0003279_aneurysm0.92893216
66MP0005620_abnormal_muscle_contractility0.92876351
67MP0005636_abnormal_mineral_homeostasis0.90443316
68MP0001879_abnormal_lymphatic_vessel0.90422325
69MP0001986_abnormal_taste_sensitivity0.88627966
70MP0008469_abnormal_protein_level0.87025347
71MP0000749_muscle_degeneration0.85902080
72MP0009642_abnormal_blood_homeostasis0.85248228
73MP0002638_abnormal_pupillary_reflex0.83450822
74MP0005645_abnormal_hypothalamus_physiol0.82185010
75MP0005084_abnormal_gallbladder_morpholo0.81230328
76MP0001661_extended_life_span0.80781432
77MP0005408_hypopigmentation0.80665400
78MP0004130_abnormal_muscle_cell0.79669273
79MP0005646_abnormal_pituitary_gland0.78434414
80MP0005376_homeostasis/metabolism_phenot0.78426929
81MP0001958_emphysema0.77836036
82MP0002876_abnormal_thyroid_physiology0.77704679
83MP0006036_abnormal_mitochondrial_physio0.77299036
84MP0006276_abnormal_autonomic_nervous0.76827951
85MP0002078_abnormal_glucose_homeostasis0.76802726
86MP0009765_abnormal_xenobiotic_induced0.76301805
87MP0001984_abnormal_olfaction0.76273868
88MP0004085_abnormal_heartbeat0.75647304
89MP0003879_abnormal_hair_cell0.75539855
90MP0003690_abnormal_glial_cell0.74323959
91MP0004142_abnormal_muscle_tone0.73220266
92MP0002971_abnormal_brown_adipose0.72882530
93MP0005220_abnormal_exocrine_pancreas0.72098529
94MP0002933_joint_inflammation0.71931243
95MP0005334_abnormal_fat_pad0.71389603
96MP0003633_abnormal_nervous_system0.71116047
97MP0004043_abnormal_pH_regulation0.68297093
98MP0005369_muscle_phenotype0.67966141
99MP0005535_abnormal_body_temperature0.66943253
100MP0002106_abnormal_muscle_physiology0.66518209
101MP0003329_amyloid_beta_deposits0.64942460
102MP0006054_spinal_hemorrhage0.64675845
103MP0005379_endocrine/exocrine_gland_phen0.64140020
104MP0005171_absent_coat_pigmentation0.63776938
105MP0002972_abnormal_cardiac_muscle0.63503947
106MP0000372_irregular_coat_pigmentation0.62852343
107MP0005385_cardiovascular_system_phenoty0.62283768
108MP0001544_abnormal_cardiovascular_syste0.62283768
109MP0005266_abnormal_metabolism0.61934246
110MP0009053_abnormal_anal_canal0.61218317
111MP0006138_congestive_heart_failure0.61126740
112MP0002269_muscular_atrophy0.61064324
113MP0000639_abnormal_adrenal_gland0.60838942
114MP0004924_abnormal_behavior0.60343491
115MP0001756_abnormal_urination0.57208355
116MP0006035_abnormal_mitochondrial_morpho0.54205590
117MP0005448_abnormal_energy_balance0.54181313
118MP0005464_abnormal_platelet_physiology0.51626032
119MP0002928_abnormal_bile_duct0.50333555
120MP0002837_dystrophic_cardiac_calcinosis0.49072994
121MP0002822_catalepsy0.47509022
122MP0008874_decreased_physiological_sensi0.47475599
123MP0005395_other_phenotype0.46888145
124MP0003724_increased_susceptibility_to0.44566465
125MP0004381_abnormal_hair_follicle0.43485978
126MP0002136_abnormal_kidney_physiology0.43434740
127MP0003638_abnormal_response/metabolism_0.42622773
128MP0008873_increased_physiological_sensi0.41834943
129MP0005666_abnormal_adipose_tissue0.41074857
130MP0000579_abnormal_nail_morphology0.41028165
131MP0003075_altered_response_to0.39721185
132MP0003953_abnormal_hormone_level0.39608385
133MP0005248_abnormal_Harderian_gland0.37128818
134MP0005166_decreased_susceptibility_to0.36933151
135MP0003718_maternal_effect0.36628617
136MP0009384_cardiac_valve_regurgitation0.36275359
137MP0004782_abnormal_surfactant_physiolog0.36059144
138MP0003436_decreased_susceptibility_to0.35864662
139MP0002168_other_aberrant_phenotype0.35418280
140MP0001243_abnormal_dermal_layer0.34040122
141MP0008872_abnormal_physiological_respon0.33799232
142MP0004883_abnormal_blood_vessel0.33776120
143MP0000230_abnormal_systemic_arterial0.33406533
144MP0009115_abnormal_fat_cell0.33108588
145MP0000249_abnormal_blood_vessel0.32725052
146MP0001853_heart_inflammation0.31365121
147MP0002060_abnormal_skin_morphology0.31292639
148MP0006082_CNS_inflammation0.29945457
149MP0009672_abnormal_birth_weight0.29851509
150MP0002796_impaired_skin_barrier0.29506658
151MP0002970_abnormal_white_adipose0.28908772
152MP0001881_abnormal_mammary_gland0.27555084
153MP0000427_abnormal_hair_cycle0.27213998
154MP0002090_abnormal_vision0.26657500
155MP0005164_abnormal_response_to0.26639572
156MP0001845_abnormal_inflammatory_respons0.25622717

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.46848621
2Intrahepatic cholestasis (HP:0001406)7.43525948
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.18345526
4Prolonged partial thromboplastin time (HP:0003645)6.68772282
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.68288469
6Hypobetalipoproteinemia (HP:0003563)6.51867372
7Xanthomatosis (HP:0000991)6.40602975
8Complement deficiency (HP:0004431)5.61241265
9Hyperlipoproteinemia (HP:0010980)5.41992200
10Hypolipoproteinemia (HP:0010981)4.85594187
11Joint hemorrhage (HP:0005261)4.83542257
12Epidermoid cyst (HP:0200040)4.79164545
13Hyperammonemia (HP:0001987)4.57657383
14Abnormality of the common coagulation pathway (HP:0010990)4.57287777
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.45435386
16Hyperglycinemia (HP:0002154)4.32220519
17Abnormality of methionine metabolism (HP:0010901)4.29459738
18Fat malabsorption (HP:0002630)4.25399516
19Ketosis (HP:0001946)4.22342917
20Abnormality of sulfur amino acid metabolism (HP:0004339)4.18962478
21Hypoalphalipoproteinemia (HP:0003233)4.18667103
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.11866984
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.11714345
24Abnormality of complement system (HP:0005339)4.08615626
25Conjugated hyperbilirubinemia (HP:0002908)3.87275364
26Hypoglycemic coma (HP:0001325)3.86827050
27Abnormality of serine family amino acid metabolism (HP:0010894)3.81551702
28Abnormality of glycine metabolism (HP:0010895)3.81551702
29Hyperglycinuria (HP:0003108)3.81027525
30Abnormality of pyrimidine metabolism (HP:0004353)3.79244243
31Abnormality of the intrinsic pathway (HP:0010989)3.78541127
32Fair hair (HP:0002286)3.77465005
33Hypercholesterolemia (HP:0003124)3.76442682
34Hyperbilirubinemia (HP:0002904)3.34323133
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.31466151
36Hyperventilation (HP:0002883)3.26903667
37Abnormality of fatty-acid metabolism (HP:0004359)3.26612005
38Steatorrhea (HP:0002570)3.13274053
39Spontaneous abortion (HP:0005268)3.06364651
40Skin nodule (HP:0200036)3.03298682
41Delayed CNS myelination (HP:0002188)3.02036539
42Abnormality of serum amino acid levels (HP:0003112)3.00973384
43Myocardial infarction (HP:0001658)3.00668869
44Abnormality of nucleobase metabolism (HP:0010932)3.00306364
45Ketoacidosis (HP:0001993)3.00017866
46Hepatocellular carcinoma (HP:0001402)2.96602844
47Hypochromic microcytic anemia (HP:0004840)2.90164388
48Systemic lupus erythematosus (HP:0002725)2.83666559
49Acanthocytosis (HP:0001927)2.80788347
50Generalized hypopigmentation of hair (HP:0011358)2.80514499
51Abnormality of the renal cortex (HP:0011035)2.70891794
52Mitral stenosis (HP:0001718)2.69573103
53Metabolic acidosis (HP:0001942)2.66459879
54Abnormality of purine metabolism (HP:0004352)2.60837424
55Chronic hepatic failure (HP:0100626)2.58760370
56Glomerulonephritis (HP:0000099)2.56811696
57Lethargy (HP:0001254)2.55579344
58Hypoglycemic seizures (HP:0002173)2.54292400
59Vascular calcification (HP:0004934)2.53724748
60Gaze-evoked nystagmus (HP:0000640)2.53605550
61Abnormal gallbladder morphology (HP:0012437)2.50076797
62Dicarboxylic aciduria (HP:0003215)2.48282337
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.48282337
64Abnormal biliary tract physiology (HP:0012439)2.46717966
65Bile duct proliferation (HP:0001408)2.46717966
66Cerebral edema (HP:0002181)2.44041627
67Cholelithiasis (HP:0001081)2.43823562
68Spastic diplegia (HP:0001264)2.41753710
69Keratoconus (HP:0000563)2.40756049
70Increased corneal curvature (HP:0100692)2.40756049
71Recurrent gram-negative bacterial infections (HP:0005420)2.40153228
72Cholecystitis (HP:0001082)2.38381870
73Abnormal gallbladder physiology (HP:0012438)2.38381870
74Pancreatic cysts (HP:0001737)2.37074344
75Amyloidosis (HP:0011034)2.32197929
76Neonatal onset (HP:0003623)2.31931699
77Hematochezia (HP:0002573)2.31916249
78Irritability (HP:0000737)2.31508301
79Gout (HP:0001997)2.31343142
80Blue irides (HP:0000635)2.30139954
81Cardiovascular calcification (HP:0011915)2.29613533
82Gingival bleeding (HP:0000225)2.27102607
83Esophageal varix (HP:0002040)2.22527878
84Potter facies (HP:0002009)2.19096274
85Facial shape deformation (HP:0011334)2.19096274
86Congenital sensorineural hearing impairment (HP:0008527)2.16807660
87Malnutrition (HP:0004395)2.16344550
88Calf muscle hypertrophy (HP:0008981)2.13665365
89Bundle branch block (HP:0011710)2.13061384
90Sensorimotor neuropathy (HP:0007141)2.11746465
91Striae distensae (HP:0001065)2.11505612
92Attenuation of retinal blood vessels (HP:0007843)2.11498907
93Menorrhagia (HP:0000132)2.11447262
94Pancreatitis (HP:0001733)2.11063789
95Late onset (HP:0003584)2.10761584
96Enlarged kidneys (HP:0000105)2.09453644
97Hyperinsulinemic hypoglycemia (HP:0000825)2.09336079
98Congenital stationary night blindness (HP:0007642)2.09266628
99Poikilocytosis (HP:0004447)2.09063955
100Brushfield spots (HP:0001088)2.06451007
101Thrombophlebitis (HP:0004418)2.05790140
102Portal hypertension (HP:0001409)2.03906231
103Tubular atrophy (HP:0000092)2.02669150
104Pancreatic fibrosis (HP:0100732)2.00525059
105Vomiting (HP:0002013)2.00153327
106Hemorrhage of the eye (HP:0011885)2.00143966
107Abnormality of the gallbladder (HP:0005264)1.99546426
108Wrist flexion contracture (HP:0001239)1.96485416
109Progressive cerebellar ataxia (HP:0002073)1.96308154
110Abnormality of iron homeostasis (HP:0011031)1.96199403
111Generalized aminoaciduria (HP:0002909)1.95755239
112Pigmentary retinal degeneration (HP:0001146)1.95422335
113Genetic anticipation (HP:0003743)1.94535639
114Nephronophthisis (HP:0000090)1.94169004
115Abnormality of the renal medulla (HP:0100957)1.93739644
116Opisthotonus (HP:0002179)1.93090793
117Abnormality of transition element cation homeostasis (HP:0011030)1.91990782
118Muscle hypertrophy of the lower extremities (HP:0008968)1.91203291
119Rickets (HP:0002748)1.90977859
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.89861040
121Heart block (HP:0012722)1.89475501
122Congenital hepatic fibrosis (HP:0002612)1.89281326
123Aortic aneurysm (HP:0004942)1.89071818
124Thyroiditis (HP:0100646)1.88415127
125Tubulointerstitial fibrosis (HP:0005576)1.87915766
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84904623
127Abnormality of alanine metabolism (HP:0010916)1.84904623
128Hyperalaninemia (HP:0003348)1.84904623
129Nephritis (HP:0000123)1.84752507
130Hyperglycemia (HP:0003074)1.83520598
131Type 1 muscle fiber predominance (HP:0003803)1.83320992
132Arthropathy (HP:0003040)1.82890743
133Hypophosphatemic rickets (HP:0004912)1.82720488
134Pulmonary embolism (HP:0002204)1.81064545
135Renal cortical cysts (HP:0000803)1.81050178
136Abnormal cartilage morphology (HP:0002763)1.81016038
137Abnormality of the calf musculature (HP:0001430)1.80243296
138Tubulointerstitial abnormality (HP:0001969)1.79788864
139Abnormality of the hepatic vasculature (HP:0006707)1.79759485
140Elevated hepatic transaminases (HP:0002910)1.78771709
141Hydroxyprolinuria (HP:0003080)1.78317350
142Abnormality of proline metabolism (HP:0010907)1.78317350
143Atrial fibrillation (HP:0005110)1.78290763
144Alkalosis (HP:0001948)1.77697690
145Abnormal enzyme/coenzyme activity (HP:0012379)1.77481764
146True hermaphroditism (HP:0010459)1.77205536
147Decreased circulating renin level (HP:0003351)1.76903128
148Spontaneous hematomas (HP:0007420)1.75361709
149Oligomenorrhea (HP:0000876)1.73855891
150Abnormality of midbrain morphology (HP:0002418)1.73217684
151Molar tooth sign on MRI (HP:0002419)1.73217684
152Status epilepticus (HP:0002133)1.72510735
153Abnormality of vitamin metabolism (HP:0100508)1.71989999
154Cerebral palsy (HP:0100021)1.71683148
155Hyporeflexia of lower limbs (HP:0002600)1.70944178
156Absent speech (HP:0001344)1.69372581
157Large for gestational age (HP:0001520)1.68413462

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.81170185
2SIK14.62833478
3FGFR44.39665920
4ERN13.85474069
5INSRR3.26392015
6TAOK33.09469356
7ERBB43.05938696
8MAP2K42.38487565
9MST1R2.32481592
10PKN22.07968646
11PIK3CG2.03006848
12ADRBK22.02032455
13ACVR1B1.91167025
14MAPK111.89162670
15FLT31.86366519
16BMPR1B1.86231167
17DAPK21.84560256
18MYLK1.78298630
19NTRK31.75249064
20LATS11.70247541
21FGFR21.65908883
22FRK1.65528526
23NLK1.57725470
24MAP4K21.57443924
25TYK21.56390365
26TRIB31.55774525
27TRPM71.55067449
28NEK91.48334416
29FER1.41331131
30AKT31.41172715
31PTK61.37484140
32ABL21.37056564
33KIT1.29778773
34MAP3K71.28891364
35JAK21.24841150
36WNK31.23293439
37KDR1.21765363
38PINK11.19456915
39PRKAA21.19211284
40ADRBK11.18723666
41MAPK131.18189750
42DDR21.13841757
43PTK2B1.13044996
44PHKG11.12413151
45PHKG21.12413151
46JAK11.11481405
47NUAK11.08778649
48ERBB21.07640644
49TEC1.05840954
50PRKCE1.05665787
51MAPKAPK31.04133084
52MET1.01430095
53CAMK1D1.01352250
54MAPK40.98099816
55EPHA30.97669597
56STK30.97649732
57TBK10.95211064
58EPHB10.94321152
59MAP3K140.94138922
60CASK0.92583924
61MAP3K100.91374307
62MAP3K40.90908559
63PRKCZ0.89750535
64OXSR10.86556257
65MAP2K30.86296294
66BLK0.85465962
67GRK60.84567594
68MAPK150.82282656
69MAPK120.80159018
70TIE10.80156729
71PRKACG0.79814566
72CAMK2G0.78779859
73STK38L0.76643206
74CAMKK20.75967648
75TGFBR10.72331298
76PRKG10.72247033
77STK390.71698713
78IKBKB0.71607712
79SGK30.71096941
80CSK0.70537220
81PRKAA10.70399548
82RIPK10.69319761
83CDK60.68797553
84TGFBR20.68401183
85ZAK0.68247941
86FGFR30.67641045
87GSK3A0.67330276
88MUSK0.66128937
89MAP3K30.65466813
90TNIK0.64446731
91EIF2AK30.62020745
92DYRK1B0.59896272
93CSF1R0.59148065
94MAPK70.59016974
95PRKACA0.58773494
96CAMK10.58364851
97PKN10.58273301
98MARK10.57001308
99MAP3K110.56801782
100RET0.56801479
101GRK50.56223225
102CDC42BPA0.55957867
103PDPK10.54549708
104MAP2K60.54178175
105PRKD10.54084917
106SGK20.54059483
107PRKCQ0.51459428
108IGF1R0.50925800
109TNK20.50852108
110CAMK2A0.50833936
111GRK10.50247942
112TXK0.49980478
113MAP2K10.49518043
114IKBKE0.49438975
115CAMK1G0.49291668
116CHUK0.49287931
117PTK20.49093231
118PDGFRB0.48722314
119PIK3CA0.48404523
120GRK70.47292663
121STK110.47253010
122IRAK30.47197400
123CSNK1G10.44558724
124ABL10.44300438
125SGK2230.42930906
126SGK4940.42930906
127SYK0.42862871
128ITK0.42653478
129MAP3K50.42636785
130PRKCG0.41266786
131LATS20.41095051
132STK380.39651955
133MAP3K130.39252027
134BMPR20.37861678
135PDK30.36952991
136PDK40.36952991
137PDK10.36805043
138MAP3K60.36703078
139EPHA40.36656497
140EGFR0.36215922
141MTOR0.36002871
142PDK20.35233072
143MELK0.35126487
144ROCK10.34919723
145ICK0.34477788
146RPS6KA30.34283871
147MAP3K10.33330085
148CAMK40.33234098
149PAK30.33023815
150TAOK20.31866804
151IRAK10.30130988
152MAP3K20.28751776
153PDGFRA0.28462599
154PRKCA0.26996311
155OBSCN0.26597123
156CSNK1G20.26268242
157PRKACB0.24974827
158IRAK20.24850797

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.55987385
2Nitrogen metabolism_Homo sapiens_hsa009103.78758511
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37035254
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.32389200
5Arginine biosynthesis_Homo sapiens_hsa002203.07773883
6Complement and coagulation cascades_Homo sapiens_hsa046102.83186230
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70985414
8Tryptophan metabolism_Homo sapiens_hsa003802.69251103
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.56322482
10Fatty acid degradation_Homo sapiens_hsa000712.50898401
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49822401
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38055688
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.21907437
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16714885
15Butanoate metabolism_Homo sapiens_hsa006502.14067296
16Peroxisome_Homo sapiens_hsa041462.06751081
17Propanoate metabolism_Homo sapiens_hsa006401.96300883
18Chemical carcinogenesis_Homo sapiens_hsa052041.96098749
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93774215
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.90427786
21PPAR signaling pathway_Homo sapiens_hsa033201.90307487
22Histidine metabolism_Homo sapiens_hsa003401.89532030
23Fatty acid metabolism_Homo sapiens_hsa012121.83296328
24Staphylococcus aureus infection_Homo sapiens_hsa051501.79898546
25Caffeine metabolism_Homo sapiens_hsa002321.75310439
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75045574
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.73772760
28beta-Alanine metabolism_Homo sapiens_hsa004101.71767780
29Retinol metabolism_Homo sapiens_hsa008301.69601304
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65379227
31Phenylalanine metabolism_Homo sapiens_hsa003601.55375384
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54284086
33Selenocompound metabolism_Homo sapiens_hsa004501.52885543
34Bile secretion_Homo sapiens_hsa049761.50577122
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47682430
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45922585
37Tyrosine metabolism_Homo sapiens_hsa003501.44040297
38Pyruvate metabolism_Homo sapiens_hsa006201.35728711
39Fatty acid elongation_Homo sapiens_hsa000621.35208856
40Starch and sucrose metabolism_Homo sapiens_hsa005001.31423741
41Sulfur metabolism_Homo sapiens_hsa009201.27301777
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.25567800
43Fat digestion and absorption_Homo sapiens_hsa049751.18162632
44Steroid biosynthesis_Homo sapiens_hsa001001.18151421
45Biosynthesis of amino acids_Homo sapiens_hsa012301.16695063
46Folate biosynthesis_Homo sapiens_hsa007901.12828246
47* ABC transporters_Homo sapiens_hsa020101.12590869
48Carbon metabolism_Homo sapiens_hsa012001.11455920
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03221217
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.98162423
51Vitamin B6 metabolism_Homo sapiens_hsa007500.97996252
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.94881667
53Arginine and proline metabolism_Homo sapiens_hsa003300.93714779
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.91039726
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87015996
56Vitamin digestion and absorption_Homo sapiens_hsa049770.86834969
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85067258
58Sulfur relay system_Homo sapiens_hsa041220.83142803
59Lysine degradation_Homo sapiens_hsa003100.81149928
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.74028879
61Circadian rhythm_Homo sapiens_hsa047100.70342112
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69439510
63Glycerolipid metabolism_Homo sapiens_hsa005610.69235502
64One carbon pool by folate_Homo sapiens_hsa006700.66832027
65ECM-receptor interaction_Homo sapiens_hsa045120.66259506
66Glutathione metabolism_Homo sapiens_hsa004800.65111919
67Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62094032
68Serotonergic synapse_Homo sapiens_hsa047260.61196475
69Fatty acid biosynthesis_Homo sapiens_hsa000610.61056219
70Phototransduction_Homo sapiens_hsa047440.55464401
71Pentose phosphate pathway_Homo sapiens_hsa000300.54162287
72Dilated cardiomyopathy_Homo sapiens_hsa054140.51765763
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.49714083
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.49594861
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49095358
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47984897
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44981044
78Ether lipid metabolism_Homo sapiens_hsa005650.44312149
79Metabolic pathways_Homo sapiens_hsa011000.43766823
80Renin secretion_Homo sapiens_hsa049240.41875502
81Dorso-ventral axis formation_Homo sapiens_hsa043200.41326479
82Prion diseases_Homo sapiens_hsa050200.40036885
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37501147
84Calcium signaling pathway_Homo sapiens_hsa040200.35320262
85Mineral absorption_Homo sapiens_hsa049780.32592980
86Insulin secretion_Homo sapiens_hsa049110.32355648
87Asthma_Homo sapiens_hsa053100.30641730
88Pertussis_Homo sapiens_hsa051330.30483041
89Salivary secretion_Homo sapiens_hsa049700.28312794
90Platelet activation_Homo sapiens_hsa046110.28290520
91Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.27879220
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.26577183
93Morphine addiction_Homo sapiens_hsa050320.26569204
94Insulin resistance_Homo sapiens_hsa049310.26094378
95Adipocytokine signaling pathway_Homo sapiens_hsa049200.25538672
96Circadian entrainment_Homo sapiens_hsa047130.24845176
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24380335
98Galactose metabolism_Homo sapiens_hsa000520.23993759
99Glutamatergic synapse_Homo sapiens_hsa047240.23406346
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.23351180
101Fructose and mannose metabolism_Homo sapiens_hsa000510.20988641
102Olfactory transduction_Homo sapiens_hsa047400.20191246
103GABAergic synapse_Homo sapiens_hsa047270.19859082
104Taste transduction_Homo sapiens_hsa047420.19193342
105Linoleic acid metabolism_Homo sapiens_hsa005910.18718028
106Type II diabetes mellitus_Homo sapiens_hsa049300.18040287
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17783391
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17578466
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17070894
110Sphingolipid metabolism_Homo sapiens_hsa006000.16756874
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.15089912
112Glucagon signaling pathway_Homo sapiens_hsa049220.13458379
113AMPK signaling pathway_Homo sapiens_hsa041520.03559622
114Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2289398
115Bladder cancer_Homo sapiens_hsa05219-0.2286794
116Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2180962
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2176007
118Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2175959
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2124343
120Amoebiasis_Homo sapiens_hsa05146-0.1962172
121Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1813735
122Hepatitis C_Homo sapiens_hsa05160-0.1784480
123Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1780698
124Renin-angiotensin system_Homo sapiens_hsa04614-0.1765134
125Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1515180
126African trypanosomiasis_Homo sapiens_hsa05143-0.1504753
127Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1472960
128Regulation of autophagy_Homo sapiens_hsa04140-0.1408118
129Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1334778
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0936760
131Insulin signaling pathway_Homo sapiens_hsa04910-0.0622047
132Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0606676
133Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0489797
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0380660

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