ABCA7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.47279637
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.44080741
3antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.44080741
4antigen processing and presentation of endogenous antigen (GO:0019883)5.99661273
5negative regulation of cell killing (GO:0031342)5.45602809
6negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.45602809
7regulation of gamma-delta T cell differentiation (GO:0045586)5.38402425
8positive thymic T cell selection (GO:0045059)5.15634245
9regulation of gamma-delta T cell activation (GO:0046643)4.98455150
10detection of other organism (GO:0098543)4.87640238
11detection of bacterium (GO:0016045)4.81286952
12leukocyte aggregation (GO:0070486)4.48514356
13macrophage activation involved in immune response (GO:0002281)4.36741998
14negative regulation of lymphocyte mediated immunity (GO:0002707)4.13329853
15positive regulation of B cell differentiation (GO:0045579)4.10299538
16thymic T cell selection (GO:0045061)4.08601597
17positive T cell selection (GO:0043368)4.07498837
18negative regulation of erythrocyte differentiation (GO:0045647)4.05081584
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.03638389
20detection of external biotic stimulus (GO:0098581)4.00014683
21negative thymic T cell selection (GO:0045060)3.95113117
22negative T cell selection (GO:0043383)3.88108880
23positive regulation of histone deacetylation (GO:0031065)3.86787492
24JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.84038284
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.81157395
26positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.80766824
27negative regulation of leukocyte mediated immunity (GO:0002704)3.72680976
28T cell selection (GO:0045058)3.71955678
29response to interleukin-15 (GO:0070672)3.67141249
30antigen processing and presentation via MHC class Ib (GO:0002475)3.64930086
31NIK/NF-kappaB signaling (GO:0038061)3.61581851
32negative regulation of T cell mediated immunity (GO:0002710)3.58194330
33leukocyte migration involved in inflammatory response (GO:0002523)3.58052959
34regulation of mast cell degranulation (GO:0043304)3.57965431
35regulation of B cell receptor signaling pathway (GO:0050855)3.55810683
36tolerance induction (GO:0002507)3.55266365
37regulation of B cell differentiation (GO:0045577)3.55126247
38regulation of interleukin-12 biosynthetic process (GO:0045075)3.52063246
39detection of molecule of bacterial origin (GO:0032490)3.49621514
40germinal center formation (GO:0002467)3.49154472
41detection of biotic stimulus (GO:0009595)3.45972839
42negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.45547456
43B cell receptor signaling pathway (GO:0050853)3.45268765
44regulation of T cell tolerance induction (GO:0002664)3.39660322
45regulation of myeloid leukocyte mediated immunity (GO:0002886)3.39169575
46response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.34906280
47response to host immune response (GO:0052572)3.34906280
48T cell migration (GO:0072678)3.34430819
49regulation of leukocyte degranulation (GO:0043300)3.30757434
50positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.28895648
51leukocyte cell-cell adhesion (GO:0007159)3.28610104
52response to muramyl dipeptide (GO:0032495)3.28441369
53regulation of tolerance induction (GO:0002643)3.28139317
54regulation of mast cell activation involved in immune response (GO:0033006)3.25663259
55defense response to protozoan (GO:0042832)3.22731048
56response to host defenses (GO:0052200)3.16528143
57response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.16528143
58response to host (GO:0075136)3.16528143
59production of molecular mediator involved in inflammatory response (GO:0002532)3.16345347
60neutrophil activation involved in immune response (GO:0002283)3.09070613
61regulation of T-helper 2 cell differentiation (GO:0045628)3.08212570
62negative regulation of innate immune response (GO:0045824)3.06090632
63macrophage activation (GO:0042116)3.05783280
64neutrophil activation (GO:0042119)3.05577231
65microglial cell activation (GO:0001774)3.02054830
66megakaryocyte development (GO:0035855)3.01204391
67negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.99521385
68negative regulation of T-helper cell differentiation (GO:0045623)2.99521385
69natural killer cell differentiation (GO:0001779)2.97748466
70respiratory burst (GO:0045730)2.97411616
71positive regulation of protein deacetylation (GO:0090312)2.97186107
72negative regulation of type 2 immune response (GO:0002829)2.96871889
73response to peptidoglycan (GO:0032494)2.96595905
74negative regulation of interleukin-12 production (GO:0032695)2.96419736
75negative regulation of phagocytosis (GO:0050765)2.93679324
76positive regulation of granulocyte differentiation (GO:0030854)2.92369826
77negative regulation of interleukin-6 production (GO:0032715)2.90927620
78positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.89244494
79T cell homeostasis (GO:0043029)2.88924361
80interferon-gamma production (GO:0032609)2.88520879
81granulocyte activation (GO:0036230)2.88468772
82regulation of mast cell activation (GO:0033003)2.87929380
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87654521
84negative regulation of cytokine production involved in immune response (GO:0002719)2.86058076
85mannose metabolic process (GO:0006013)2.85744626
86regulation of regulated secretory pathway (GO:1903305)2.84673425
87antigen receptor-mediated signaling pathway (GO:0050851)2.83343990
88positive regulation of mast cell activation (GO:0033005)2.82382665
89positive regulation of interferon-alpha production (GO:0032727)2.81559075
90cellular extravasation (GO:0045123)2.81388857
91T cell receptor signaling pathway (GO:0050852)2.79402890
92regulation of erythrocyte differentiation (GO:0045646)2.79024179
93response to type I interferon (GO:0034340)2.77635896
94positive regulation by symbiont of host defense response (GO:0052509)2.77511429
95modulation by symbiont of host defense response (GO:0052031)2.77511429
96modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.77511429
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.77511429
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.77511429
99modulation by symbiont of host immune response (GO:0052553)2.77511429
100regulation of type I interferon-mediated signaling pathway (GO:0060338)2.76004954
101cellular response to zinc ion (GO:0071294)2.75824090
102T cell proliferation (GO:0042098)2.75198697
103neutrophil mediated immunity (GO:0002446)2.74192978
104cellular response to interleukin-15 (GO:0071350)2.73886438
105response to fungus (GO:0009620)2.72834079
106positive regulation of tolerance induction (GO:0002645)2.72466658
107lymphocyte homeostasis (GO:0002260)2.71001834
108negative regulation of bone resorption (GO:0045779)2.70922581
109regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70585815
110myeloid dendritic cell activation (GO:0001773)2.70043337
111mature B cell differentiation (GO:0002335)2.68654611
112myeloid dendritic cell differentiation (GO:0043011)2.68159862
113Arp2/3 complex-mediated actin nucleation (GO:0034314)2.67582758
114T cell costimulation (GO:0031295)2.64996002
115type I interferon signaling pathway (GO:0060337)2.64724933
116cellular response to type I interferon (GO:0071357)2.64724933
117adaptation of signaling pathway (GO:0023058)2.64681862
118immunoglobulin mediated immune response (GO:0016064)2.63230915
119erythrocyte maturation (GO:0043249)2.61591450
120interferon-gamma-mediated signaling pathway (GO:0060333)2.61398607
121regulation of alpha-beta T cell proliferation (GO:0046640)2.60520606
122positive regulation of interleukin-2 production (GO:0032743)2.59539322
123lymphocyte costimulation (GO:0031294)2.59320669
124defense response to fungus (GO:0050832)2.58372514
125regulation of response to interferon-gamma (GO:0060330)2.54375315
126myeloid cell activation involved in immune response (GO:0002275)2.54299878
127regulation of interferon-beta biosynthetic process (GO:0045357)2.54101521
128regulation of natural killer cell mediated immunity (GO:0002715)2.52345190
129regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.52345190
130positive regulation of antigen processing and presentation (GO:0002579)2.51869955
131mucosal-associated lymphoid tissue development (GO:0048537)2.50593219
132Peyers patch development (GO:0048541)2.50593219
133activated T cell proliferation (GO:0050798)2.49583847
134regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.49238745
135positive regulation of isotype switching (GO:0045830)2.48846978
136leukocyte degranulation (GO:0043299)2.48123268
137positive regulation of natural killer cell differentiation (GO:0032825)2.47042395
138regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.46647670
139response to protozoan (GO:0001562)2.44826133
140sequestering of metal ion (GO:0051238)2.44572053
141response to laminar fluid shear stress (GO:0034616)2.43460355
142mast cell activation (GO:0045576)2.42766967

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16813762
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.66262277
3MYC_22102868_ChIP-Seq_BL_Human3.56149193
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.49433364
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.41082436
6* VDR_21846776_ChIP-Seq_THP-1_Human3.37992841
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.32873372
8E2F7_22180533_ChIP-Seq_HELA_Human3.00947287
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.93239743
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.73693886
11SCL_19346495_ChIP-Seq_HPC-7_Human2.65239606
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62810296
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.61361195
14* MAF_26560356_Chip-Seq_TH1_Human2.57174708
15* TCF7_22412390_ChIP-Seq_EML_Mouse2.56594759
16FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46471510
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41131024
18* VDR_24763502_ChIP-Seq_THP-1_Human2.38590594
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.35348502
20* UTX_26944678_Chip-Seq_JUKART_Human2.34503137
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.32244882
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.32057235
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.31846673
24MYB_26560356_Chip-Seq_TH2_Human2.31299494
25RUNX_20019798_ChIP-Seq_JUKART_Human2.31279339
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.29991297
27KDM2B_26808549_Chip-Seq_DND41_Human2.29942456
28GATA1_22025678_ChIP-Seq_K562_Human2.27501291
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23835467
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23041770
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.22453393
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.19238741
33KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18017771
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.13841992
35* RUNX1_22412390_ChIP-Seq_EML_Mouse2.10880060
36* MYB_26560356_Chip-Seq_TH1_Human2.07585610
37SPI1_23127762_ChIP-Seq_K562_Human2.03646502
38* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.02243739
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.92726534
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89002641
41* ELK3_25401928_ChIP-Seq_HUVEC_Human1.88431244
42SPI1_23547873_ChIP-Seq_NB4_Human1.84778139
43GATA1_19941827_ChIP-Seq_MEL_Mouse1.79004975
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78672738
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.73582499
46MAF_26560356_Chip-Seq_TH2_Human1.70211564
47BP1_19119308_ChIP-ChIP_Hs578T_Human1.68702094
48TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68360752
49* GATA1_19941826_ChIP-Seq_K562_Human1.64537670
50LXR_22292898_ChIP-Seq_THP-1_Human1.62060827
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57586759
52FOXM1_23109430_ChIP-Seq_U2OS_Human1.57530960
53GATA3_27048872_Chip-Seq_THYMUS_Human1.56932888
54GATA1_22383799_ChIP-Seq_G1ME_Mouse1.56427105
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47822866
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.47213528
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.44670036
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.43969141
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43070512
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40757487
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38713688
62* THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37789416
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35873975
64CIITA_25753668_ChIP-Seq_RAJI_Human1.35785604
65NCOR1_26117541_ChIP-Seq_K562_Human1.32994536
66* GATA2_19941826_ChIP-Seq_K562_Human1.30345818
67PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29797606
68* PU_27001747_Chip-Seq_BMDM_Mouse1.28973744
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.25330309
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25138280
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25076372
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22951049
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22071077
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18631418
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.16495995
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16269100
77NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16088546
78Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.13729580
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13177403
80GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12784635
81SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12635840
82* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11269638
83SMC4_20622854_ChIP-Seq_HELA_Human1.10553188
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07966490
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07254220
86RACK7_27058665_Chip-Seq_MCF-7_Human1.07207136
87VDR_24787735_ChIP-Seq_THP-1_Human1.07074881
88CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05742303
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05407099
90KDM2B_26808549_Chip-Seq_K562_Human1.04344581
91* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04174833
92* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01814974
93CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01288953
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.00959349
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.00671445
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97701218
97ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97645458
98CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97127160
99SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.96223073
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.96024254
101* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94893164
102EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94599107
103GATA3_26560356_Chip-Seq_TH2_Human0.94332623
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93789689
105* P68_20966046_ChIP-Seq_HELA_Human0.93253997
106RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92310252
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.92113000
108* BCOR_27268052_Chip-Seq_Bcells_Human0.91924745
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91636330
110STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89600767
111* BCL6_27268052_Chip-Seq_Bcells_Human0.88978745
112FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88445977
113* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87918656

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.63549886
2MP0000685_abnormal_immune_system3.21214548
3MP0001835_abnormal_antigen_presentation3.19730558
4MP0003300_gastrointestinal_ulcer3.03392270
5MP0003436_decreased_susceptibility_to2.86024896
6MP0005671_abnormal_response_to2.73213287
7MP0001800_abnormal_humoral_immune2.71110875
8MP0005387_immune_system_phenotype2.70992051
9MP0001790_abnormal_immune_system2.70992051
10MP0009278_abnormal_bone_marrow2.65324226
11MP0005000_abnormal_immune_tolerance2.48984860
12MP0003763_abnormal_thymus_physiology2.45168108
13MP0004510_myositis2.42774981
14MP0002420_abnormal_adaptive_immunity2.35030433
15MP0002723_abnormal_immune_serum2.34800037
16MP0001819_abnormal_immune_cell2.32878777
17MP0002452_abnormal_antigen_presenting2.32503629
18MP0002877_abnormal_melanocyte_morpholog2.32388888
19MP0005464_abnormal_platelet_physiology2.29584140
20MP0002398_abnormal_bone_marrow2.28326628
21MP0008260_abnormal_autophagy2.26745005
22MP0002166_altered_tumor_susceptibility2.22198486
23MP0005025_abnormal_response_to2.22075141
24MP0002419_abnormal_innate_immunity2.17439363
25MP0003183_abnormal_peptide_metabolism2.14892793
26MP0005451_abnormal_body_composition2.07914197
27MP0002396_abnormal_hematopoietic_system2.06693625
28MP0004808_abnormal_hematopoietic_stem2.06104753
29MP0001873_stomach_inflammation2.03624541
30MP0009785_altered_susceptibility_to2.03166031
31MP0003866_abnormal_defecation2.03133564
32MP0004947_skin_inflammation1.99543710
33MP0005397_hematopoietic_system_phenotyp1.99445354
34MP0001545_abnormal_hematopoietic_system1.99445354
35MP0000716_abnormal_immune_system1.99258216
36MP0003172_abnormal_lysosome_physiology1.89713367
37MP0002132_abnormal_respiratory_system1.88576920
38MP0002405_respiratory_system_inflammati1.84208929
39MP0002722_abnormal_immune_system1.81034351
40MP0002148_abnormal_hypersensitivity_rea1.78583256
41MP0008961_abnormal_basal_metabolism1.76417612
42MP0000689_abnormal_spleen_morphology1.75131330
43MP0005076_abnormal_cell_differentiation1.74077459
44MP0010155_abnormal_intestine_physiology1.73861555
45MP0000703_abnormal_thymus_morphology1.72952483
46MP0002429_abnormal_blood_cell1.69745724
47MP0000465_gastrointestinal_hemorrhage1.68629962
48MP0001845_abnormal_inflammatory_respons1.61558645
49MP0005310_abnormal_salivary_gland1.58318963
50MP0003656_abnormal_erythrocyte_physiolo1.56631184
51MP0009333_abnormal_splenocyte_physiolog1.56275484
52MP0002006_tumorigenesis1.55410873
53MP0000569_abnormal_digit_pigmentation1.54127264
54MP0004381_abnormal_hair_follicle1.53422598
55MP0010352_gastrointestinal_tract_polyps1.51101709
56MP0005058_abnormal_lysosome_morphology1.47552560
57MP0010307_abnormal_tumor_latency1.44264508
58MP0003045_fibrosis1.40137661
59MP0006082_CNS_inflammation1.39389542
60MP0005174_abnormal_tail_pigmentation1.38987157
61MP0001853_heart_inflammation1.31290621
62MP0003566_abnormal_cell_adhesion1.30531271
63MP0001533_abnormal_skeleton_physiology1.28915681
64MP0001986_abnormal_taste_sensitivity1.28416455
65MP0003724_increased_susceptibility_to1.25898644
66MP0000858_altered_metastatic_potential1.19672651
67MP0004883_abnormal_blood_vessel1.13765721
68MP0002933_joint_inflammation1.07599458
69MP0000490_abnormal_crypts_of1.04045034
70MP0002693_abnormal_pancreas_physiology1.02633593
71MP0008469_abnormal_protein_level1.02134519
72MP0003690_abnormal_glial_cell1.00268559
73MP0001851_eye_inflammation0.94278513
74MP0003448_altered_tumor_morphology0.93290156
75MP0002277_abnormal_respiratory_mucosa0.90895377
76MP0003705_abnormal_hypodermis_morpholog0.90069590
77MP0002735_abnormal_chemical_nociception0.82770164
78MP0005023_abnormal_wound_healing0.82269858
79MP0002909_abnormal_adrenal_gland0.81905751
80MP0005164_abnormal_response_to0.81783117
81MP0005166_decreased_susceptibility_to0.77119485
82MP0002019_abnormal_tumor_incidence0.76381298
83MP0005390_skeleton_phenotype0.74573781
84MP0001663_abnormal_digestive_system0.74360405
85MP0002009_preneoplasia0.73964600
86MP0001348_abnormal_lacrimal_gland0.73930111
87MP0009763_increased_sensitivity_to0.72377291
88MP0002928_abnormal_bile_duct0.72261925
89MP0000371_diluted_coat_color0.70188040
90MP0003091_abnormal_cell_migration0.70077269
91MP0008004_abnormal_stomach_pH0.70048078
92MP0002998_abnormal_bone_remodeling0.69297734
93MP0005621_abnormal_cell_physiology0.68474961
94MP0002138_abnormal_hepatobiliary_system0.66390742
95MP0001270_distended_abdomen0.66257262
96MP0003453_abnormal_keratinocyte_physiol0.65274247
97MP0003828_pulmonary_edema0.64133837
98MP0000343_altered_response_to0.61800398
99MP0003795_abnormal_bone_structure0.61435945
100MP0009764_decreased_sensitivity_to0.60995339
101MP0003191_abnormal_cellular_cholesterol0.60711713
102MP0004264_abnormal_extraembryonic_tissu0.60094576
103MP0004130_abnormal_muscle_cell0.59931772
104MP0000015_abnormal_ear_pigmentation0.59113429
105MP0005075_abnormal_melanosome_morpholog0.58446924
106MP0000313_abnormal_cell_death0.58093327
107MP0009840_abnormal_foam_cell0.58036349
108MP0000249_abnormal_blood_vessel0.58019792
109MP0001944_abnormal_pancreas_morphology0.57380931
110MP0000609_abnormal_liver_physiology0.57231406
111MP0008874_decreased_physiological_sensi0.55581072
112MP0005083_abnormal_biliary_tract0.55579742
113MP0009765_abnormal_xenobiotic_induced0.55118564
114MP0003221_abnormal_cardiomyocyte_apopto0.54673182
115MP0004185_abnormal_adipocyte_glucose0.53929004
116MP0004858_abnormal_nervous_system0.53573454
117MP0003075_altered_response_to0.53416640
118MP0005666_abnormal_adipose_tissue0.53385680
119MP0000604_amyloidosis0.52954483
120MP0009931_abnormal_skin_appearance0.52579431

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.98038135
2Orchitis (HP:0100796)4.55236159
3Retrobulbar optic neuritis (HP:0100654)4.27978833
4Optic neuritis (HP:0100653)4.27978833
5Recurrent abscess formation (HP:0002722)4.25811406
6Recurrent fungal infections (HP:0002841)4.17846233
7Abnormality of the fingertips (HP:0001211)4.05709627
8Abnormal delayed hypersensitivity skin test (HP:0002963)4.01551160
9Recurrent bacterial skin infections (HP:0005406)3.82672713
10Nasal polyposis (HP:0100582)3.81956768
11Chronic otitis media (HP:0000389)3.76269761
12Recurrent viral infections (HP:0004429)3.76144151
13Recurrent cutaneous fungal infections (HP:0011370)3.45319241
14Chronic mucocutaneous candidiasis (HP:0002728)3.45319241
15Abnormality of the nasal mucosa (HP:0000433)3.43331464
16Encephalitis (HP:0002383)3.35428426
17Hypochromic anemia (HP:0001931)3.29909218
18IgM deficiency (HP:0002850)3.29534560
19Hypochromic microcytic anemia (HP:0004840)3.27380764
20Cellulitis (HP:0100658)3.22816187
21Inflammation of the large intestine (HP:0002037)3.17732284
22Keratoconjunctivitis sicca (HP:0001097)3.15486133
23Colitis (HP:0002583)3.15371364
24Gastrointestinal inflammation (HP:0004386)3.14933468
25Recurrent bronchitis (HP:0002837)3.13082747
26Elevated erythrocyte sedimentation rate (HP:0003565)3.11859826
27Recurrent skin infections (HP:0001581)3.08907416
28Thrombocytosis (HP:0001894)3.06494112
29Autoimmune thrombocytopenia (HP:0001973)3.02820466
30Increased IgE level (HP:0003212)3.00581042
31Interstitial pulmonary disease (HP:0006530)2.99646246
32Urticaria (HP:0001025)2.98112444
33Prolonged bleeding time (HP:0003010)2.96795613
34Pustule (HP:0200039)2.94235599
35T lymphocytopenia (HP:0005403)2.93639525
36Panhypogammaglobulinemia (HP:0003139)2.91721882
37Keratoconjunctivitis (HP:0001096)2.88013906
38Meningitis (HP:0001287)2.87714507
39Mediastinal lymphadenopathy (HP:0100721)2.84704380
40Myositis (HP:0100614)2.81321635
41Abnormality of T cell number (HP:0011839)2.79935365
42Papilloma (HP:0012740)2.72245897
43Verrucae (HP:0200043)2.72245897
44Abnormality of T cells (HP:0002843)2.67248531
45Abnormality of macrophages (HP:0004311)2.66534516
46Recurrent gram-negative bacterial infections (HP:0005420)2.66168407
47Obstructive lung disease (HP:0006536)2.63940749
48Chronic obstructive pulmonary disease (HP:0006510)2.63940749
49Episodic fever (HP:0001954)2.61833363
50Gingivitis (HP:0000230)2.61255669
51Spontaneous hematomas (HP:0007420)2.60492080
52Abnormal platelet function (HP:0011869)2.58836024
53Impaired platelet aggregation (HP:0003540)2.58836024
54Vasculitis (HP:0002633)2.58167282
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.53370476
56Hyperacusis (HP:0010780)2.50198620
57Agammaglobulinemia (HP:0004432)2.49632805
58Abnormality of T cell physiology (HP:0011840)2.45928853
59Epistaxis (HP:0000421)2.43690628
60Anorexia (HP:0002039)2.40032442
61Pulmonary embolism (HP:0002204)2.37518779
62Abnormality of B cell number (HP:0010975)2.36881825
63B lymphocytopenia (HP:0010976)2.36881825
64Chest pain (HP:0100749)2.36815136
65Gastrointestinal infarctions (HP:0005244)2.35480351
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.33626039
67Microcytic anemia (HP:0001935)2.33277004
68Petechiae (HP:0000967)2.30928131
69Increased IgM level (HP:0003496)2.27777897
70Periodontitis (HP:0000704)2.26962940
71Stomatitis (HP:0010280)2.23634039
72Lymphopenia (HP:0001888)2.23534297
73Osteomyelitis (HP:0002754)2.23211130
74Leukocytosis (HP:0001974)2.22450821
75Eosinophilia (HP:0001880)2.21713615
76Increased serum ferritin (HP:0003281)2.19773802
77Slow saccadic eye movements (HP:0000514)2.19771373
78Cerebral aneurysm (HP:0004944)2.18914291
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.18790083
80Purpura (HP:0000979)2.17767507
81Restrictive lung disease (HP:0002091)2.15506246
82Viral hepatitis (HP:0006562)2.14752215
83Amyloidosis (HP:0011034)2.13534777
84Peritonitis (HP:0002586)2.11964954
85Emphysema (HP:0002097)2.11939651
86Hypertensive crisis (HP:0100735)2.08288967
87Dysostosis multiplex (HP:0000943)2.07111427
88Hemoptysis (HP:0002105)2.06557757
89Gastrointestinal stroma tumor (HP:0100723)2.06467286
90Abnormality of the pleura (HP:0002103)2.06406641
91Abnormal platelet volume (HP:0011876)2.05949337
92Hypergammaglobulinemia (HP:0010702)2.05702735
93Increased density of long bones (HP:0006392)2.03291103
94Loss of speech (HP:0002371)2.03141706
95Arterial thrombosis (HP:0004420)2.02895546
96Abnormality of iron homeostasis (HP:0011031)2.02867723
97Abnormality of the peritoneum (HP:0002585)2.02756152
98Macroorchidism (HP:0000053)2.02107208
99Hepatosplenomegaly (HP:0001433)1.99851999
100Mucopolysacchariduria (HP:0008155)1.98483501
101Urinary glycosaminoglycan excretion (HP:0003541)1.98483501
102Metaphyseal cupping (HP:0003021)1.98448790
103Hematochezia (HP:0002573)1.97569126
104Acne (HP:0001061)1.97148245
105Pulmonary infiltrates (HP:0002113)1.96100136
106Premature loss of primary teeth (HP:0006323)1.94012477
107Thyroiditis (HP:0100646)1.93417102
108Hemorrhage of the eye (HP:0011885)1.93064861
109Hypercortisolism (HP:0001578)1.93034493
110Abnormality of mucopolysaccharide metabolism (HP:0011020)1.92736786
111Abnormality of polysaccharide metabolism (HP:0011012)1.92736786
112Abnormality of glycosaminoglycan metabolism (HP:0004371)1.92736786
113Granulocytopenia (HP:0001913)1.92675735
114Recurrent sinusitis (HP:0011108)1.92456579
115Papilledema (HP:0001085)1.91788462
116Severe short stature (HP:0003510)1.91389278
117Gingival bleeding (HP:0000225)1.91050009
118Gangrene (HP:0100758)1.89974063
119Abnormality of eosinophils (HP:0001879)1.88813139
120Reticulocytosis (HP:0001923)1.87907604
121Fatigue (HP:0012378)1.87770941
122Acute hepatic failure (HP:0006554)1.87246790
123Skin ulcer (HP:0200042)1.86709174
124Glomerulopathy (HP:0100820)1.86205314
125Polycythemia (HP:0001901)1.84372072
126Bicuspid aortic valve (HP:0001647)1.84061679
127Sepsis (HP:0100806)1.83730882
128Poikilocytosis (HP:0004447)1.83681117
129Thoracic kyphosis (HP:0002942)1.83511026
130Increased cerebral lipofuscin (HP:0011813)1.83426369
131Abnormality of the thoracic spine (HP:0100711)1.83382552
132Abnormality of the endocardium (HP:0004306)1.81540783
133Polygenic inheritance (HP:0010982)1.80949052
134IgA deficiency (HP:0002720)1.80591388
135Chronic sinusitis (HP:0011109)1.78508488
136Thoracolumbar scoliosis (HP:0002944)1.78227615
137Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78074224
138Vacuolated lymphocytes (HP:0001922)1.75790116

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.99729496
2EEF2K3.35281360
3PRPF4B3.01765643
4TRIB32.82567405
5JAK32.46460008
6TYK22.45380547
7PKN22.42197614
8MAP3K102.24127821
9IRAK42.09331665
10RIPK42.07460800
11ZAP702.02980509
12JAK11.98225818
13ERN11.93552113
14TAOK31.93343985
15EPHB11.85479160
16MAP3K141.84839095
17TBK11.84467542
18GRK61.84035983
19BTK1.76711464
20SIK21.73752042
21IKBKE1.65518405
22ITK1.64790238
23STK101.61285162
24TTN1.60841547
25TXK1.57658323
26FGFR41.56503025
27MAP3K31.53949811
28RIPK11.52659056
29PTK61.50755060
30SYK1.48015482
31LRRK21.47048852
32MAP3K111.46311972
33KIT1.40852724
34BLK1.40168308
35CDK121.39871444
36MAP3K131.39725790
37MAP2K31.36620315
38FES1.35549228
39SMG11.33696780
40HCK1.32324988
41FGFR31.31279794
42FLT31.27997971
43JAK21.27697472
44FGR1.27670597
45HIPK21.26777531
46LCK1.15643465
47CSK1.13746599
48TEC1.08807869
49MAP3K21.06462374
50IKBKB1.03919180
51CDC42BPA1.02504964
52PIM11.00474828
53MARK30.98869808
54RPS6KA20.96873801
55RET0.96630247
56CSF1R0.94551987
57MAP3K60.93997127
58PRKCH0.91834559
59IRAK30.90930624
60TAOK20.90012762
61ICK0.88614608
62EPHA30.88057693
63ALK0.87601660
64TGFBR20.87128501
65YES10.86571418
66TRPM70.86494256
67CHUK0.85293492
68MAP3K70.84617088
69PDPK10.84564282
70MAPKAPK30.83589408
71IRAK20.82386546
72MAPK120.80187216
73SIK10.78413104
74SCYL20.77206967
75CAMK1G0.75527759
76RPS6KA40.74650028
77RPS6KA60.73681605
78TAOK10.71260259
79MAP3K10.71151368
80RPS6KC10.69734981
81RPS6KL10.69734981
82CAMKK20.67085367
83NEK20.66653037
84CAMK1D0.64633037
85MATK0.62992427
86IRAK10.62912645
87RPS6KB20.62493504
88LYN0.60857852
89BMPR20.60786778
90BRD40.59599488
91BMX0.59115078
92SGK30.58606423
93FYN0.57564307
94CLK10.56904691
95TESK20.56332345
96TNK20.54488685
97NLK0.54074467
98KSR20.53757243
99MAP2K60.53687728
100MAPK70.53147026
101PDK10.52798205
102PRKD20.51436168
103PASK0.49084342
104PDGFRB0.48882999
105PRKCQ0.46871206
106STK380.46760773
107MARK20.46741675
108MAP2K20.45730857
109PTK20.44267969
110STK40.43657235
111MTOR0.41842384
112CAMKK10.41825534
113CDK40.41698036
114CDK60.41334054
115NTRK10.40205130
116MAPK110.39193514
117MAPKAPK20.38565462
118PTK2B0.36988235
119SIK30.36663092
120PRKG20.36501959
121PDGFRA0.36148333
122DYRK1B0.34942690
123STK110.34821970
124MAP3K80.34065857
125MAP2K40.31163935

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.63823450
2Leishmaniasis_Homo sapiens_hsa051402.45514167
3B cell receptor signaling pathway_Homo sapiens_hsa046622.30593844
4Osteoclast differentiation_Homo sapiens_hsa043802.25930085
5Autoimmune thyroid disease_Homo sapiens_hsa053201.99781975
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.92990938
7Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.83183326
8T cell receptor signaling pathway_Homo sapiens_hsa046601.78874171
9Chronic myeloid leukemia_Homo sapiens_hsa052201.78085730
10Measles_Homo sapiens_hsa051621.77910830
11Hematopoietic cell lineage_Homo sapiens_hsa046401.73075477
12Acute myeloid leukemia_Homo sapiens_hsa052211.70888995
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67205976
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.61539264
15Toxoplasmosis_Homo sapiens_hsa051451.61194968
16Antigen processing and presentation_Homo sapiens_hsa046121.60049626
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58480605
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.53099657
19Chemokine signaling pathway_Homo sapiens_hsa040621.52181782
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48859327
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.48757740
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.48130559
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.47862707
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.47078055
25Type II diabetes mellitus_Homo sapiens_hsa049301.43479247
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.41826035
27Apoptosis_Homo sapiens_hsa042101.39942811
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38960207
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37091000
30Platelet activation_Homo sapiens_hsa046111.36999058
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32285366
32Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.31502536
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.28745496
34Prolactin signaling pathway_Homo sapiens_hsa049171.28706147
35Tuberculosis_Homo sapiens_hsa051521.28000093
36TNF signaling pathway_Homo sapiens_hsa046681.27220393
37Influenza A_Homo sapiens_hsa051641.22753148
38Pancreatic cancer_Homo sapiens_hsa052121.21540006
39Hepatitis B_Homo sapiens_hsa051611.19970648
40African trypanosomiasis_Homo sapiens_hsa051431.18031789
41Insulin resistance_Homo sapiens_hsa049311.15894515
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15028961
43Non-small cell lung cancer_Homo sapiens_hsa052231.14044591
44Pertussis_Homo sapiens_hsa051331.11587307
45Herpes simplex infection_Homo sapiens_hsa051681.11487401
46Shigellosis_Homo sapiens_hsa051311.09849389
47mTOR signaling pathway_Homo sapiens_hsa041501.09805198
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08966981
49VEGF signaling pathway_Homo sapiens_hsa043701.08115891
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.03673527
51Glycosaminoglycan degradation_Homo sapiens_hsa005311.00336251
52Phagosome_Homo sapiens_hsa041450.97838060
53Other glycan degradation_Homo sapiens_hsa005110.96356274
54Legionellosis_Homo sapiens_hsa051340.95726098
55Salmonella infection_Homo sapiens_hsa051320.90678139
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.89967429
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87716939
58Hepatitis C_Homo sapiens_hsa051600.86742510
59Viral myocarditis_Homo sapiens_hsa054160.85060695
60Small cell lung cancer_Homo sapiens_hsa052220.81004555
61Lysosome_Homo sapiens_hsa041420.80809272
62Dorso-ventral axis formation_Homo sapiens_hsa043200.80138129
63Viral carcinogenesis_Homo sapiens_hsa052030.77394627
64GnRH signaling pathway_Homo sapiens_hsa049120.76587138
65Staphylococcus aureus infection_Homo sapiens_hsa051500.75960322
66Asthma_Homo sapiens_hsa053100.75720758
67Estrogen signaling pathway_Homo sapiens_hsa049150.75614803
68Inositol phosphate metabolism_Homo sapiens_hsa005620.75328097
69Malaria_Homo sapiens_hsa051440.72941393
70HTLV-I infection_Homo sapiens_hsa051660.72882194
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72535074
72Insulin signaling pathway_Homo sapiens_hsa049100.72531214
73Glioma_Homo sapiens_hsa052140.72178744
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.71998177
75FoxO signaling pathway_Homo sapiens_hsa040680.70706910
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70519043
77Endocytosis_Homo sapiens_hsa041440.69883971
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69830711
79Allograft rejection_Homo sapiens_hsa053300.69753616
80Colorectal cancer_Homo sapiens_hsa052100.67374354
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.67260861
82Epstein-Barr virus infection_Homo sapiens_hsa051690.65416000
83Rheumatoid arthritis_Homo sapiens_hsa053230.65299224
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65285311
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.64255287
86Lysine degradation_Homo sapiens_hsa003100.62525450
87HIF-1 signaling pathway_Homo sapiens_hsa040660.61487222
88Amoebiasis_Homo sapiens_hsa051460.61149853
89ErbB signaling pathway_Homo sapiens_hsa040120.60750205
90MAPK signaling pathway_Homo sapiens_hsa040100.60307710
91Endometrial cancer_Homo sapiens_hsa052130.59704335
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59283988
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59002402
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58803254
95Renal cell carcinoma_Homo sapiens_hsa052110.57254693
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57107951
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.56710520
98Notch signaling pathway_Homo sapiens_hsa043300.56004970
99Graft-versus-host disease_Homo sapiens_hsa053320.55391429
100Proteoglycans in cancer_Homo sapiens_hsa052050.55353270
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54858195
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53341550
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53339461
104Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.52992355
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52515627
106Caffeine metabolism_Homo sapiens_hsa002320.52424527
107Type I diabetes mellitus_Homo sapiens_hsa049400.50864742
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48430763
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47890640
110Prostate cancer_Homo sapiens_hsa052150.45700926
111Pancreatic secretion_Homo sapiens_hsa049720.45217228
112Choline metabolism in cancer_Homo sapiens_hsa052310.44917349
113Rap1 signaling pathway_Homo sapiens_hsa040150.43155095
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42794001

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