ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	7.40293918
2	DNA replication checkpoint (GO:0000076)	5.86486407
3	regulation of translational fidelity (GO:0006450)	5.32997803
4	resolution of meiotic recombination intermediates (GO:0000712)	5.19771412
5	valine metabolic process (GO:0006573)	4.48637450
6	DNA unwinding involved in DNA replication (GO:0006268)	4.48465541
7	DNA strand elongation involved in DNA replication (GO:0006271)	4.45375341
8	DNA strand elongation (GO:0022616)	4.34041939
9	regulation of histone H3-K27 methylation (GO:0061085)	4.33855566
10	DNA topological change (GO:0006265)	4.27456318
11	nuclear pore complex assembly (GO:0051292)	4.23170636
12	diterpenoid biosynthetic process (GO:0016102)	4.13345231
13	DNA replication initiation (GO:0006270)	4.12157772
14	IMP biosynthetic process (GO:0006188)	4.02410947
15	protein-cofactor linkage (GO:0018065)	3.98150869
16	mitotic sister chromatid segregation (GO:0000070)	3.95136863
17	terpenoid biosynthetic process (GO:0016114)	3.91354683
18	oxaloacetate metabolic process (GO:0006107)	3.87754639
19	regulation of histone H3-K4 methylation (GO:0051569)	3.86538941
20	synapsis (GO:0007129)	3.83403715
21	homocysteine metabolic process (GO:0050667)	3.81560711
22	proline biosynthetic process (GO:0006561)	3.80082532
23	ribosome biogenesis (GO:0042254)	3.79084385
24	sister chromatid segregation (GO:0000819)	3.77292529
25	meiotic chromosome segregation (GO:0045132)	3.76866613
26	mitotic nuclear envelope disassembly (GO:0007077)	3.76100617
27	creatine metabolic process (GO:0006600)	3.71881627
28	nuclear pore organization (GO:0006999)	3.68866730
29	gas transport (GO:0015669)	3.66509494
30	IMP metabolic process (GO:0046040)	3.61554421
31	mitotic chromosome condensation (GO:0007076)	3.61323666
32	microtubule depolymerization (GO:0007019)	3.56018230
33	ribosomal small subunit biogenesis (GO:0042274)	3.54736665
34	nucleobase biosynthetic process (GO:0046112)	3.50938296
35	replication fork processing (GO:0031297)	3.50263595
36	ribonucleoprotein complex biogenesis (GO:0022613)	3.50065961
37	kinetochore organization (GO:0051383)	3.46500263
38	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.45715601
39	purine nucleobase biosynthetic process (GO:0009113)	3.45702978
40	viral transcription (GO:0019083)	3.44276149
41	pseudouridine synthesis (GO:0001522)	3.43058881
42	oxygen transport (GO:0015671)	3.41297288
43	protoporphyrinogen IX metabolic process (GO:0046501)	3.40061873
44	translational termination (GO:0006415)	3.38953128
45	membrane disassembly (GO:0030397)	3.37529951
46	nuclear envelope disassembly (GO:0051081)	3.37529951
47	ribosomal small subunit assembly (GO:0000028)	3.35763795
48	regulation of translational elongation (GO:0006448)	3.34670233
49	protein localization to kinetochore (GO:0034501)	3.33132508
50	amino acid activation (GO:0043038)	3.32988717
51	tRNA aminoacylation (GO:0043039)	3.32988717
52	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.32621783
53	nucleoside transmembrane transport (GO:1901642)	3.32612812
54	misfolded or incompletely synthesized protein catabolic process (GO:0006515)	3.31359311
55	regulation of mitotic spindle organization (GO:0060236)	3.31281769
56	vitamin A metabolic process (GO:0006776)	3.29319620
57	regulation of RNA export from nucleus (GO:0046831)	3.27938290
58	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.27682078
59	potassium ion export (GO:0071435)	3.26496234
60	kinetochore assembly (GO:0051382)	3.24079217
61	telomere maintenance via semi-conservative replication (GO:0032201)	3.23644317
62	protoporphyrinogen IX biosynthetic process (GO:0006782)	3.21802287
63	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.21416195
64	tRNA aminoacylation for protein translation (GO:0006418)	3.21183843
65	chromosome segregation (GO:0007059)	3.20896538
66	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.20641666
67	ATP synthesis coupled proton transport (GO:0015986)	3.20641666
68	negative regulation of erythrocyte differentiation (GO:0045647)	3.16225029
69	pore complex assembly (GO:0046931)	3.14748101
70	centriole replication (GO:0007099)	3.09060905
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.03123152
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.03123152
73	translational elongation (GO:0006414)	2.97400766
74	erythrocyte maturation (GO:0043249)	2.97176709
75	formation of translation preinitiation complex (GO:0001731)	2.96716389
76	ribosomal large subunit biogenesis (GO:0042273)	2.95836241
77	definitive hemopoiesis (GO:0060216)	2.95093616
78	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.92596567
79	granulocyte differentiation (GO:0030851)	2.91514684
80	GMP metabolic process (GO:0046037)	2.90671149
81	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.90039245
82	DNA methylation involved in gamete generation (GO:0043046)	2.89515384
83	membrane repolarization during action potential (GO:0086011)	2.87738740
84	regulation of spindle organization (GO:0090224)	2.86255427
85	tetrahydrofolate metabolic process (GO:0046653)	2.86131738
86	protein complex disassembly (GO:0043241)	2.84574918
87	phosphorelay signal transduction system (GO:0000160)	2.83907821
88	positive regulation of histone H3-K4 methylation (GO:0051571)	2.83357552
89	cellular protein complex disassembly (GO:0043624)	2.82767704
90	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.81806264
91	regulation of centrosome cycle (GO:0046605)	2.81663346
92	chromosome condensation (GO:0030261)	2.80722792
93	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.80293754
94	succinate metabolic process (GO:0006105)	2.79943463
95	maturation of 5.8S rRNA (GO:0000460)	2.79506043
96	pyrimidine nucleotide catabolic process (GO:0006244)	2.78977311
97	protein localization to chromosome, centromeric region (GO:0071459)	2.78640431
98	histone phosphorylation (GO:0016572)	2.78046445
99	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.77975667
100	mitotic recombination (GO:0006312)	2.74196060

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	7.57356707
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.36965618
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.48862423
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.46654131
5	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.30776219
6	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.21453797
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.18273709
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.84379390
9	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.81215325
10	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.71661507
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.68743176
12	NCOR1_26117541_ChIP-Seq_K562_Human	2.63754744
13	GATA1_19941826_ChIP-Seq_K562_Human	2.59971270
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.52058535
15	EGR1_19374776_ChIP-ChIP_THP-1_Human	2.47402610
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.46891969
17	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.45459326
18	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.40857420
19	GATA1_22025678_ChIP-Seq_K562_Human	2.36824110
20	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.24655167
21	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.18774741
22	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.18115441
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01466321
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.95281146
25	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.92235890
26	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.91651188
27	ZNF263_19887448_ChIP-Seq_K562_Human	1.91297011
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.84566496
29	GABP_19822575_ChIP-Seq_HepG2_Human	1.78811514
30	DCP1A_22483619_ChIP-Seq_HELA_Human	1.77103950
31	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.75780958
32	TTF2_22483619_ChIP-Seq_HELA_Human	1.74751990
33	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74308175
34	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.72799747
35	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62159774
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60953952
37	MYC_22102868_ChIP-Seq_BL_Human	1.58543348
38	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.58120179
39	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.56771656
40	VDR_23849224_ChIP-Seq_CD4+_Human	1.56758465
41	FOXP3_21729870_ChIP-Seq_TREG_Human	1.54687553
42	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.53048958
43	GATA2_19941826_ChIP-Seq_K562_Human	1.52460206
44	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.50486912
45	KDM5A_27292631_Chip-Seq_BREAST_Human	1.49759265
46	MYC_18940864_ChIP-ChIP_HL60_Human	1.46575278
47	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.46441303
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.45914371
49	SCL_19346495_ChIP-Seq_HPC-7_Human	1.44223461
50	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43559692
51	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.42812974
52	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.39609997
53	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.36261696
54	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.35645326
55	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.35247315
56	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.33981369
57	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.32403152
58	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.31709290
59	ELK1_19687146_ChIP-ChIP_HELA_Human	1.30890237
60	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.30753010
61	SPI1_23127762_ChIP-Seq_K562_Human	1.29136252
62	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.28604759
63	CIITA_25753668_ChIP-Seq_RAJI_Human	1.27657970
64	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.22449978
65	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.21344346
66	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19826139
67	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.19820823
68	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.16041943
69	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.15039577
70	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.12803663
71	VDR_21846776_ChIP-Seq_THP-1_Human	1.07471904
72	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.05934979
73	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.05772849
74	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.04454861
75	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.04001038
76	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.98314987
77	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.98046388
78	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.97678695
79	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.95874013
80	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95620017
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95216220
82	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.93808531
83	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.92428673
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.92057183
85	P68_20966046_ChIP-Seq_HELA_Human	0.91585323
86	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.91476109
87	AR_21909140_ChIP-Seq_LNCAP_Human	0.90942402
88	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.90456500
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89076384
90	VDR_22108803_ChIP-Seq_LS180_Human	0.88744866
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.87184312
92	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.85966373
93	E2F1_20622854_ChIP-Seq_HELA_Human	0.84527188
94	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.84114341
95	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.84075735
96	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.83768194
97	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.82592071
98	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	0.81841488
99	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.80211743
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.80158086

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.82259321
2	MP0004145_abnormal_muscle_electrophysio	4.38651035
3	MP0008995_early_reproductive_senescence	3.88120275
4	MP0008058_abnormal_DNA_repair	3.80789850
5	MP0003693_abnormal_embryo_hatching	3.28306363
6	MP0003111_abnormal_nucleus_morphology	3.24417252
7	MP0010094_abnormal_chromosome_stability	3.19168692
8	MP0000678_abnormal_parathyroid_gland	3.12285175
9	MP0008007_abnormal_cellular_replicative	2.94252383
10	MP0003806_abnormal_nucleotide_metabolis	2.65815767
11	MP0004957_abnormal_blastocyst_morpholog	2.56502134
12	MP0003950_abnormal_plasma_membrane	2.47651499
13	MP0002249_abnormal_larynx_morphology	2.24337492
14	MP0003656_abnormal_erythrocyte_physiolo	2.08358044
15	MP0001764_abnormal_homeostasis	2.07832748
16	MP0003077_abnormal_cell_cycle	2.07556243
17	MP0008932_abnormal_embryonic_tissue	1.94009948
18	MP0003786_premature_aging	1.93526890
19	MP0008057_abnormal_DNA_replication	1.83327310
20	MP0006292_abnormal_olfactory_placode	1.82047324
21	MP0002234_abnormal_pharynx_morphology	1.78015518
22	MP0003718_maternal_effect	1.63344390
23	MP0006276_abnormal_autonomic_nervous	1.59518214
24	MP0009697_abnormal_copulation	1.59137392
25	MP0004885_abnormal_endolymph	1.58025471
26	MP0001545_abnormal_hematopoietic_system	1.55854647
27	MP0005397_hematopoietic_system_phenotyp	1.55854647
28	MP0001529_abnormal_vocalization	1.50225998
29	MP0002009_preneoplasia	1.49016677
30	MP0001929_abnormal_gametogenesis	1.48584013
31	MP0000350_abnormal_cell_proliferation	1.47855005
32	MP0004084_abnormal_cardiac_muscle	1.47627326
33	MP0005645_abnormal_hypothalamus_physiol	1.42061807
34	MP0006036_abnormal_mitochondrial_physio	1.40301992
35	MP0001730_embryonic_growth_arrest	1.31433625
36	MP0003959_abnormal_lean_body	1.29458470
37	MP0000566_synostosis	1.27120800
38	MP0001697_abnormal_embryo_size	1.26415055
39	MP0000313_abnormal_cell_death	1.21025444
40	MP0003137_abnormal_impulse_conducting	1.18949145
41	MP0002210_abnormal_sex_determination	1.18395898
42	MP0006138_congestive_heart_failure	1.17558101
43	MP0001502_abnormal_circadian_rhythm	1.16669791
44	MP0003984_embryonic_growth_retardation	1.15908693
45	MP0005083_abnormal_biliary_tract	1.14332271
46	MP0005380_embryogenesis_phenotype	1.13971358
47	MP0001672_abnormal_embryogenesis/_devel	1.13971358
48	MP0009379_abnormal_foot_pigmentation	1.13706318
49	MP0002938_white_spotting	1.13175642
50	MP0010307_abnormal_tumor_latency	1.12630905
51	MP0002088_abnormal_embryonic_growth/wei	1.10392542
52	MP0000428_abnormal_craniofacial_morphol	1.08406246
53	MP0000747_muscle_weakness	1.04162037
54	MP0004742_abnormal_vestibular_system	1.02727438
55	MP0003646_muscle_fatigue	1.01982030
56	MP0003186_abnormal_redox_activity	1.00893926
57	MP0009278_abnormal_bone_marrow	1.00360072
58	MP0002080_prenatal_lethality	0.99773897
59	MP0003937_abnormal_limbs/digits/tail_de	0.96809411
60	MP0006035_abnormal_mitochondrial_morpho	0.96777678
61	MP0003698_abnormal_male_reproductive	0.96484305
62	MP0002095_abnormal_skin_pigmentation	0.95996109
63	MP0000372_irregular_coat_pigmentation	0.94761803
64	MP0003172_abnormal_lysosome_physiology	0.90861105
65	MP0005171_absent_coat_pigmentation	0.90804689
66	MP0004036_abnormal_muscle_relaxation	0.90271187
67	MP0002282_abnormal_trachea_morphology	0.89549680
68	MP0009672_abnormal_birth_weight	0.86399014
69	MP0001299_abnormal_eye_distance/	0.86354651
70	MP0005253_abnormal_eye_physiology	0.83962812
71	MP0005636_abnormal_mineral_homeostasis	0.83779565
72	MP0001881_abnormal_mammary_gland	0.81181546
73	MP0004808_abnormal_hematopoietic_stem	0.79541480
74	MP0005535_abnormal_body_temperature	0.79506056
75	MP0002086_abnormal_extraembryonic_tissu	0.79121427
76	MP0001145_abnormal_male_reproductive	0.78695777
77	MP0002084_abnormal_developmental_patter	0.78623341
78	MP0009384_cardiac_valve_regurgitation	0.78300866
79	MP0002398_abnormal_bone_marrow	0.77808430
80	MP0002396_abnormal_hematopoietic_system	0.77373897
81	MP0005646_abnormal_pituitary_gland	0.76423721
82	MP0004197_abnormal_fetal_growth/weight/	0.76018938
83	MP0005391_vision/eye_phenotype	0.75694458
84	MP0003567_abnormal_fetal_cardiomyocyte	0.75116880
85	MP0000631_abnormal_neuroendocrine_gland	0.74267684
86	MP0002019_abnormal_tumor_incidence	0.73567822
87	MP0002161_abnormal_fertility/fecundity	0.72779309
88	MP0003385_abnormal_body_wall	0.72772865
89	MP0000703_abnormal_thymus_morphology	0.72396632
90	MP0000653_abnormal_sex_gland	0.72215076
91	MP0002085_abnormal_embryonic_tissue	0.72044839
92	MP0005058_abnormal_lysosome_morphology	0.72012766
93	MP0003315_abnormal_perineum_morphology	0.71542559
94	MP0001661_extended_life_span	0.70422939
95	MP0005187_abnormal_penis_morphology	0.69024745
96	MP0005174_abnormal_tail_pigmentation	0.68965984
97	MP0003699_abnormal_female_reproductive	0.68837288
98	MP0002269_muscular_atrophy	0.67595414
99	MP0003136_yellow_coat_color	0.67247478
100	MP0005451_abnormal_body_composition	0.66287313

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Truncus arteriosus (HP:0001660)	7.32784055
2	Hyperthyroidism (HP:0000836)	6.74118443
3	Hypertensive crisis (HP:0100735)	5.97951682
4	Birth length less than 3rd percentile (HP:0003561)	4.63174132
5	Abnormal gallbladder physiology (HP:0012438)	4.60999956
6	Cholecystitis (HP:0001082)	4.60999956
7	Seborrheic dermatitis (HP:0001051)	4.53040494
8	Reticulocytosis (HP:0001923)	4.47247655
9	Polycythemia (HP:0001901)	4.28254157
10	Bowel incontinence (HP:0002607)	4.17637020
11	Abnormal large intestine physiology (HP:0012700)	4.07556644
12	Abnormality of reticulocytes (HP:0004312)	3.83854956
13	Abnormality of the tricuspid valve (HP:0001702)	3.68491408
14	Chronic obstructive pulmonary disease (HP:0006510)	3.64173802
15	Obstructive lung disease (HP:0006536)	3.64173802
16	Hypoparathyroidism (HP:0000829)	3.63572269
17	Increased serum pyruvate (HP:0003542)	3.50779477
18	Tinnitus (HP:0000360)	3.46549741
19	Abnormality of glycolysis (HP:0004366)	3.44726858
20	Atelectasis (HP:0100750)	3.31462380
21	11 pairs of ribs (HP:0000878)	3.23595562
22	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.05717888
23	Pallor (HP:0000980)	3.03521868
24	Acute encephalopathy (HP:0006846)	3.00443915
25	Abnormal hemoglobin (HP:0011902)	2.99551863
26	Abnormality of homocysteine metabolism (HP:0010919)	2.96805039
27	Homocystinuria (HP:0002156)	2.96805039
28	Midline defect of the nose (HP:0004122)	2.89769597
29	Ileus (HP:0002595)	2.85383313
30	Limb hypertonia (HP:0002509)	2.82418351
31	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.81217743
32	Cholelithiasis (HP:0001081)	2.80328037
33	Morphological abnormality of the inner ear (HP:0011390)	2.74225541
34	Patellar dislocation (HP:0002999)	2.70911985
35	Abnormally folded helix (HP:0008544)	2.70517320
36	Abnormality of cells of the erythroid lineage (HP:0012130)	2.70428722
37	Pheochromocytoma (HP:0002666)	2.69988295
38	Duplicated collecting system (HP:0000081)	2.69565961
39	Chromsome breakage (HP:0040012)	2.69353701
40	Abnormal number of erythroid precursors (HP:0012131)	2.68783942
41	Ankyloglossia (HP:0010296)	2.65778222
42	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.63709861
43	Spastic paraparesis (HP:0002313)	2.56039879
44	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.53198968
45	Cortical dysplasia (HP:0002539)	2.52637271
46	Flat cornea (HP:0007720)	2.51951795
47	Poor head control (HP:0002421)	2.50760671
48	Reticulocytopenia (HP:0001896)	2.50025926
49	Overriding aorta (HP:0002623)	2.46153539
50	Poikilocytosis (HP:0004447)	2.45428093
51	Breast hypoplasia (HP:0003187)	2.44121792
52	Abnormal gallbladder morphology (HP:0012437)	2.44072226
53	Overfolded helix (HP:0000396)	2.41023512
54	Neuroendocrine neoplasm (HP:0100634)	2.40445771
55	Cheekbone underdevelopment (HP:0010669)	2.36299967
56	Concave nail (HP:0001598)	2.33761543
57	Venous insufficiency (HP:0005293)	2.33099537
58	Abnormality of the renal collecting system (HP:0004742)	2.31485567
59	Progressive microcephaly (HP:0000253)	2.28633330
60	Septate vagina (HP:0001153)	2.23495196
61	Acute myeloid leukemia (HP:0004808)	2.22324935
62	Abnormality of the diencephalon (HP:0010662)	2.22172177
63	Abnormality of the pons (HP:0007361)	2.21843468
64	Acute necrotizing encephalopathy (HP:0006965)	2.17247792
65	Hypoplastic iliac wings (HP:0002866)	2.17015042
66	Meningioma (HP:0002858)	2.10803791
67	Abnormality of lateral ventricle (HP:0030047)	2.08306964
68	Hypoplasia of the pons (HP:0012110)	2.08202133
69	Insomnia (HP:0100785)	2.07033768
70	Abnormality of cochlea (HP:0000375)	2.04556472
71	Abnormal mitochondria in muscle tissue (HP:0008316)	2.03440335
72	Macrocytic anemia (HP:0001972)	2.02929531
73	Missing ribs (HP:0000921)	2.02715285
74	Dysmetric saccades (HP:0000641)	2.02180141
75	Peripheral hypomyelination (HP:0007182)	1.99097238
76	Abnormality of T cell physiology (HP:0011840)	1.98219263
77	Thin ribs (HP:0000883)	1.97780707
78	Redundant skin (HP:0001582)	1.97706293
79	Tetany (HP:0001281)	1.96095180
80	Ventricular fibrillation (HP:0001663)	1.93844502
81	Facial hemangioma (HP:0000329)	1.91673609
82	Abnormality of the gallbladder (HP:0005264)	1.91626667
83	Abnormality of the aortic arch (HP:0012303)	1.91523432
84	Abnormality of DNA repair (HP:0003254)	1.85699411
85	Venous abnormality (HP:0002624)	1.84856258
86	Spinal cord lesions (HP:0100561)	1.84616302
87	Syringomyelia (HP:0003396)	1.84616302
88	Breech presentation (HP:0001623)	1.83148055
89	Polycystic kidney dysplasia (HP:0000113)	1.82858670
90	Upper limb muscle weakness (HP:0003484)	1.82505555
91	Capillary hemangiomas (HP:0005306)	1.80390724
92	Neoplasm of the peripheral nervous system (HP:0100007)	1.79489003
93	Abnormality of the thymus (HP:0000777)	1.75625508
94	Agammaglobulinemia (HP:0004432)	1.71009734
95	Abnormality of the carotid arteries (HP:0005344)	1.70770536
96	Female pseudohermaphroditism (HP:0010458)	1.70011941
97	Progressive macrocephaly (HP:0004481)	1.69592727
98	Attention deficit hyperactivity disorder (HP:0007018)	1.69408104
99	Palpitations (HP:0001962)	1.68106577
100	Decreased subcutaneous fat (HP:0001002)	1.65824702

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TSSK6	4.24855965
2	RIPK4	3.55969396
3	WEE1	3.32031704
4	TAOK3	3.26451244
5	BMPR2	3.06481520
6	CLK1	3.03466456
7	KSR2	3.02429335
8	CDC7	2.97375935
9	TTK	2.94766217
10	LATS2	2.83611136
11	EEF2K	2.75552454
12	EIF2AK1	2.39746062
13	NTRK3	2.25927711
14	IRAK1	2.12013648
15	MAP3K2	2.03998833
16	BUB1	1.86299155
17	CDK12	1.85526214
18	SRPK1	1.82081536
19	WNK4	1.77012698
20	RAF1	1.63378320
21	KSR1	1.62176110
22	PNCK	1.59402316
23	MAPK13	1.44194131
24	MAP3K8	1.41113300
25	MAPK15	1.33093585
26	BMX	1.31884274
27	CHEK2	1.31735306
28	JAK3	1.29906689
29	NEK2	1.27807340
30	PAK1	1.22768511
31	BRSK2	1.21624743
32	IRAK4	1.21525229
33	IRAK3	1.17884424
34	TEC	1.17525354
35	PLK4	1.14330862
36	CAMK1D	1.14100610
37	ALK	1.08947674
38	PKN1	1.06747748
39	MAPKAPK5	1.05329709
40	BRAF	1.01018853
41	ATR	0.98959457
42	TRPM7	0.88397763
43	CCNB1	0.87230821
44	BTK	0.87109828
45	STK4	0.86775982
46	ZAK	0.86661603
47	JAK2	0.80428326
48	PLK1	0.79820663
49	RPS6KB2	0.77945234
50	SCYL2	0.77516172
51	CHEK1	0.76517947
52	RPS6KA5	0.75781115
53	MAPK11	0.73702251
54	BCKDK	0.72781233
55	PLK3	0.71709994
56	MAP2K1	0.68608713
57	ILK	0.68345535
58	STK3	0.67795079
59	CDK1	0.64861371
60	MKNK1	0.64595057
61	CDK2	0.62773178
62	WNK1	0.61454887
63	NEK1	0.60450245
64	RPS6KA4	0.60149435
65	CSNK1E	0.57022984
66	PRKD2	0.55570124
67	ATM	0.54806143
68	MAP2K2	0.54753841
69	RET	0.54668833
70	TLK1	0.54484552
71	MTOR	0.54162350
72	MAPK12	0.54159538
73	CDK3	0.54056202
74	DYRK3	0.53444296
75	MKNK2	0.50708574
76	AURKA	0.49864501
77	CDK7	0.47949059
78	PTK6	0.47496207
79	PIM1	0.44496071
80	NME1	0.44073136
81	PASK	0.43618849
82	AURKB	0.42997205
83	PAK2	0.42918764
84	MAP3K4	0.42374260
85	BRSK1	0.41343301
86	CSNK2A2	0.41318912
87	PRKACG	0.38898230
88	MAPKAPK3	0.38666472
89	CAMK1G	0.38515915
90	MAP3K1	0.38010590
91	CDK8	0.37634250
92	PRKAA1	0.37592473
93	TIE1	0.36457356
94	PRKCI	0.36047608
95	SYK	0.34944820
96	CSNK2A1	0.34626525
97	GSK3B	0.34259046
98	KDR	0.33991712
99	CAMK2B	0.33372298
100	AKT1	0.30942827

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.47184661
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.41827721
3	DNA replication_Homo sapiens_hsa03030	3.53507297
4	Ribosome_Homo sapiens_hsa03010	3.46976397
5	One carbon pool by folate_Homo sapiens_hsa00670	3.36334632
6	Mismatch repair_Homo sapiens_hsa03430	3.19940243
7	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.92639454
8	Sulfur relay system_Homo sapiens_hsa04122	2.82578832
9	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.55094979
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.38131641
11	Spliceosome_Homo sapiens_hsa03040	2.18802090
12	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	2.16268457
13	RNA transport_Homo sapiens_hsa03013	2.14911003
14	Parkinsons disease_Homo sapiens_hsa05012	2.01877410
15	Basal transcription factors_Homo sapiens_hsa03022	2.00636683
16	Oxidative phosphorylation_Homo sapiens_hsa00190	2.00526454
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.97064513
18	RNA polymerase_Homo sapiens_hsa03020	1.96211890
19	Cell cycle_Homo sapiens_hsa04110	1.83030303
20	Base excision repair_Homo sapiens_hsa03410	1.56632239
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.55381016
22	mRNA surveillance pathway_Homo sapiens_hsa03015	1.44633573
23	Huntingtons disease_Homo sapiens_hsa05016	1.41616673
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.41375463
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.38004219
26	Olfactory transduction_Homo sapiens_hsa04740	1.37620617
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.35552856
28	RNA degradation_Homo sapiens_hsa03018	1.34151895
29	Acute myeloid leukemia_Homo sapiens_hsa05221	1.30917411
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29083242
31	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.28803454
32	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28357855
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.24195008
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.19951391
35	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.19552782
36	Tyrosine metabolism_Homo sapiens_hsa00350	1.16830900
37	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.14458420
38	Non-homologous end-joining_Homo sapiens_hsa03450	1.11473420
39	Alzheimers disease_Homo sapiens_hsa05010	1.08405346
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.05382343
41	Purine metabolism_Homo sapiens_hsa00230	1.01797003
42	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.92114428
43	Arginine biosynthesis_Homo sapiens_hsa00220	0.82848462
44	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.80520630
45	Carbon metabolism_Homo sapiens_hsa01200	0.78592714
46	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.74681432
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74636867
48	Viral carcinogenesis_Homo sapiens_hsa05203	0.73967977
49	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.71651937
50	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.71280695
51	Pyruvate metabolism_Homo sapiens_hsa00620	0.67710559
52	Nitrogen metabolism_Homo sapiens_hsa00910	0.66962123
53	VEGF signaling pathway_Homo sapiens_hsa04370	0.66603526
54	ErbB signaling pathway_Homo sapiens_hsa04012	0.62667593
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.60908887
56	mTOR signaling pathway_Homo sapiens_hsa04150	0.60392062
57	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.57189156
58	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.56376305
59	Prion diseases_Homo sapiens_hsa05020	0.54328965
60	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.52566810
61	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.51618796
62	Bladder cancer_Homo sapiens_hsa05219	0.50245288
63	Type II diabetes mellitus_Homo sapiens_hsa04930	0.49681510
64	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49213842
65	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.48394000
66	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.47372332
67	Metabolic pathways_Homo sapiens_hsa01100	0.46870507
68	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43876443
69	Nicotine addiction_Homo sapiens_hsa05033	0.43736088
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43615292
71	Proteasome_Homo sapiens_hsa03050	0.42097537
72	Oocyte meiosis_Homo sapiens_hsa04114	0.41751361
73	Sulfur metabolism_Homo sapiens_hsa00920	0.41396261
74	Renal cell carcinoma_Homo sapiens_hsa05211	0.41298503
75	Pancreatic cancer_Homo sapiens_hsa05212	0.31526409
76	Protein export_Homo sapiens_hsa03060	0.31313056
77	Butanoate metabolism_Homo sapiens_hsa00650	0.29559311
78	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.29207144
79	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.27952642
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.27710182
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.27228711
82	Non-small cell lung cancer_Homo sapiens_hsa05223	0.27150339
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27122068
84	p53 signaling pathway_Homo sapiens_hsa04115	0.26912145
85	Choline metabolism in cancer_Homo sapiens_hsa05231	0.25997539
86	Alcoholism_Homo sapiens_hsa05034	0.24600542
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.23835760
88	Propanoate metabolism_Homo sapiens_hsa00640	0.23243700
89	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.21327383
90	Insulin signaling pathway_Homo sapiens_hsa04910	0.21136429
91	Prolactin signaling pathway_Homo sapiens_hsa04917	0.20285116
92	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.18152018
93	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.16867782
94	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.16541665
95	Antigen processing and presentation_Homo sapiens_hsa04612	0.16203578
96	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.15229770
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.14938687
98	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14206144
99	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.12239816
100	Ether lipid metabolism_Homo sapiens_hsa00565	0.12162386

ABCB10P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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