ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nuclear pore complex assembly (GO:0051292)	7.90014630
2	nuclear pore organization (GO:0006999)	6.96268630
3	regulation of translational fidelity (GO:0006450)	6.20995110
4	pore complex assembly (GO:0046931)	5.92057671
5	DNA replication checkpoint (GO:0000076)	5.78695712
6	DNA unwinding involved in DNA replication (GO:0006268)	5.48564362
7	regulation of histone H3-K27 methylation (GO:0061085)	5.46670885
8	diterpenoid biosynthetic process (GO:0016102)	5.46174486
9	DNA topological change (GO:0006265)	5.23202404
10	regulation of histone H3-K4 methylation (GO:0051569)	5.06679464
11	mitotic sister chromatid segregation (GO:0000070)	5.04835779
12	sister chromatid segregation (GO:0000819)	5.00548760
13	terpenoid biosynthetic process (GO:0016114)	4.98325286
14	protoporphyrinogen IX metabolic process (GO:0046501)	4.93439455
15	regulation of RNA export from nucleus (GO:0046831)	4.92601511
16	mitotic nuclear envelope disassembly (GO:0007077)	4.79675151
17	DNA replication initiation (GO:0006270)	4.50981785
18	vitamin A metabolic process (GO:0006776)	4.49766381
19	synapsis (GO:0007129)	4.48100003
20	membrane disassembly (GO:0030397)	4.47856011
21	nuclear envelope disassembly (GO:0051081)	4.47856011
22	gas transport (GO:0015669)	4.45089963
23	formation of translation preinitiation complex (GO:0001731)	4.44265090
24	homocysteine metabolic process (GO:0050667)	4.23839759
25	resolution of meiotic recombination intermediates (GO:0000712)	4.21148666
26	mitotic chromosome condensation (GO:0007076)	4.17119905
27	oxygen transport (GO:0015671)	4.17113698
28	negative regulation of erythrocyte differentiation (GO:0045647)	4.10877399
29	protoporphyrinogen IX biosynthetic process (GO:0006782)	4.08104488
30	tRNA aminoacylation for protein translation (GO:0006418)	4.05974714
31	regulation of nucleobase-containing compound transport (GO:0032239)	4.00232794
32	erythrocyte maturation (GO:0043249)	3.97739506
33	DNA strand elongation involved in DNA replication (GO:0006271)	3.94383701
34	folic acid-containing compound biosynthetic process (GO:0009396)	3.93209846
35	regulation of mitotic spindle organization (GO:0060236)	3.92470403
36	meiotic chromosome segregation (GO:0045132)	3.92014458
37	tRNA aminoacylation (GO:0043039)	3.91460418
38	amino acid activation (GO:0043038)	3.91460418
39	microtubule depolymerization (GO:0007019)	3.87692834
40	purine nucleobase biosynthetic process (GO:0009113)	3.85682885
41	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.85120362
42	DNA strand elongation (GO:0022616)	3.83612545
43	oxidative phosphorylation (GO:0006119)	3.83206490
44	regulation of translational elongation (GO:0006448)	3.81194360
45	intra-S DNA damage checkpoint (GO:0031573)	3.79361795
46	regulation of histone methylation (GO:0031060)	3.72510923
47	proline biosynthetic process (GO:0006561)	3.66343681
48	IMP biosynthetic process (GO:0006188)	3.65031013
49	oxaloacetate metabolic process (GO:0006107)	3.63535809
50	negative regulation of histone methylation (GO:0031061)	3.62595977
51	creatine metabolic process (GO:0006600)	3.59737508
52	definitive hemopoiesis (GO:0060216)	3.57089268
53	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	3.54322966
54	chromosome segregation (GO:0007059)	3.49376126
55	tetrahydrofolate metabolic process (GO:0046653)	3.45460893
56	Golgi transport vesicle coating (GO:0048200)	3.43600364
57	COPI coating of Golgi vesicle (GO:0048205)	3.43600364
58	response to vitamin A (GO:0033189)	3.42447645
59	nucleobase biosynthetic process (GO:0046112)	3.42355238
60	protein export from nucleus (GO:0006611)	3.34045726
61	telomere maintenance via semi-conservative replication (GO:0032201)	3.31615535
62	positive regulation of histone H3-K4 methylation (GO:0051571)	3.28786251
63	protein localization to kinetochore (GO:0034501)	3.28232207
64	IMP metabolic process (GO:0046040)	3.25416477
65	nuclear envelope organization (GO:0006998)	3.24325537
66	negative regulation of potassium ion transmembrane transport (GO:1901380)	3.23046853
67	chromosome condensation (GO:0030261)	3.21858543
68	isoprenoid biosynthetic process (GO:0008299)	3.15487821
69	ribosomal large subunit biogenesis (GO:0042273)	3.10570188
70	erythrocyte development (GO:0048821)	3.08071048
71	kinetochore organization (GO:0051383)	3.06042959
72	succinate metabolic process (GO:0006105)	3.05471312
73	mitotic recombination (GO:0006312)	3.05360663
74	DNA packaging (GO:0006323)	3.04513008
75	protein localization to chromosome, centromeric region (GO:0071459)	3.04199001
76	DNA conformation change (GO:0071103)	3.04021809
77	regulation of histone H3-K9 methylation (GO:0051570)	3.01739120
78	positive regulation of histone methylation (GO:0031062)	3.01671712
79	regulation of centrosome cycle (GO:0046605)	2.97632972
80	granulocyte differentiation (GO:0030851)	2.95230870
81	iron ion import (GO:0097286)	2.94184706
82	regulation of centriole replication (GO:0046599)	2.93907671
83	telomere maintenance via recombination (GO:0000722)	2.93130048
84	mitotic metaphase plate congression (GO:0007080)	2.93011732
85	midgut development (GO:0007494)	2.92202747
86	regulation of spindle organization (GO:0090224)	2.88014816
87	DNA damage induced protein phosphorylation (GO:0006975)	2.84606084
88	DNA duplex unwinding (GO:0032508)	2.84345909
89	mRNA transport (GO:0051028)	2.83670994
90	valine metabolic process (GO:0006573)	2.83354199
91	glucose 6-phosphate metabolic process (GO:0051156)	2.82835811
92	regulation of gene expression by genetic imprinting (GO:0006349)	2.82381228
93	mitotic G2/M transition checkpoint (GO:0044818)	2.81007754
94	DNA geometric change (GO:0032392)	2.75076103
95	sensory perception of smell (GO:0007608)	2.74428521
96	DNA synthesis involved in DNA repair (GO:0000731)	2.74160141
97	DNA methylation involved in gamete generation (GO:0043046)	2.73558105
98	potassium ion export (GO:0071435)	2.72728626
99	nucleosome disassembly (GO:0006337)	2.72498399
100	protein-DNA complex disassembly (GO:0032986)	2.72498399

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	9.63107344
2	FOXM1_23109430_ChIP-Seq_U2OS_Human	4.41490366
3	EGR1_19374776_ChIP-ChIP_THP-1_Human	3.86467818
4	E2F4_17652178_ChIP-ChIP_JURKAT_Human	3.79209345
5	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	3.46277032
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.26988212
7	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.13134509
8	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.96506918
9	NCOR1_26117541_ChIP-Seq_K562_Human	2.93661709
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.91354235
11	GATA1_19941826_ChIP-Seq_K562_Human	2.71228112
12	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.54187429
13	GATA1_22025678_ChIP-Seq_K562_Human	2.51234477
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.50097434
15	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.40445543
16	XRN2_22483619_ChIP-Seq_HELA_Human	2.37076339
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.32447682
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.28679854
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.22843384
20	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	2.22408208
21	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.21529477
22	E2F1_21310950_ChIP-Seq_MCF-7_Human	2.04051002
23	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.99463501
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.97358803
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.94787492
26	TTF2_22483619_ChIP-Seq_HELA_Human	1.92490141
27	GATA2_19941826_ChIP-Seq_K562_Human	1.90702190
28	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89740905
29	DCP1A_22483619_ChIP-Seq_HELA_Human	1.89205488
30	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.88708516
31	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.84493616
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.78821562
33	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.76795229
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76739310
35	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.74860930
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.72640208
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72593247
38	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.70172752
39	KDM5A_27292631_Chip-Seq_BREAST_Human	1.62375127
40	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.61918790
41	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.60465899
42	CIITA_25753668_ChIP-Seq_RAJI_Human	1.55639119
43	FOXP3_21729870_ChIP-Seq_TREG_Human	1.52970825
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.51904257
45	MYC_22102868_ChIP-Seq_BL_Human	1.49815161
46	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.47527683
47	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	1.45262968
48	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.45033957
49	SPI1_23127762_ChIP-Seq_K562_Human	1.41761013
50	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.40569496
51	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.40334728
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.39952053
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.36793574
54	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.34563909
55	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.33618124
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.31465164
57	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28628229
58	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.27403852
59	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.26902453
60	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.25663127
61	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.25025416
62	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.23764906
63	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.20535416
64	SCL_19346495_ChIP-Seq_HPC-7_Human	1.19979741
65	KLF4_18555785_ChIP-Seq_MESCs_Mouse	1.18532685
66	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.17439874
67	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.15896750
68	ZNF263_19887448_ChIP-Seq_K562_Human	1.14570107
69	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.11130173
70	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.10731267
71	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.08933400
72	CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse	1.08933007
73	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.07514637
74	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06281658
75	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.04952313
76	TFEB_21752829_ChIP-Seq_HELA_Human	1.02012018
77	ERG_20887958_ChIP-Seq_HPC-7_Mouse	0.98080295
78	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	0.97658153
79	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.97462889
80	CHD1_26751641_Chip-Seq_LNCaP_Human	0.96898098
81	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94877758
82	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93928552
83	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.91750812
84	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.91304130
85	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.91287654
86	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90818173
87	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.90358482
88	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	0.89642063
89	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.89548740
90	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87742461
91	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	0.84808463
92	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.83818424
93	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.83573632
94	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.82594892
95	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.82505659
96	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.80605664
97	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.78211907
98	MAF_26560356_Chip-Seq_TH1_Human	0.77901487
99	PHF8_20622853_ChIP-Seq_HELA_Human	0.77804820
100	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.75268749

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	5.07660756
2	MP0008995_early_reproductive_senescence	4.13757064
3	MP0004957_abnormal_blastocyst_morpholog	4.10615000
4	MP0003111_abnormal_nucleus_morphology	3.76238055
5	MP0010094_abnormal_chromosome_stability	3.68200248
6	MP0008058_abnormal_DNA_repair	3.48987561
7	MP0003693_abnormal_embryo_hatching	3.38439580
8	MP0000678_abnormal_parathyroid_gland	3.33872074
9	MP0009697_abnormal_copulation	3.12534991
10	MP0005451_abnormal_body_composition	3.08170177
11	MP0003656_abnormal_erythrocyte_physiolo	3.06176672
12	MP0008057_abnormal_DNA_replication	2.87660716
13	MP0008932_abnormal_embryonic_tissue	2.81481189
14	MP0003077_abnormal_cell_cycle	2.50459639
15	MP0008007_abnormal_cellular_replicative	2.47238735
16	MP0003786_premature_aging	2.42640642
17	MP0004145_abnormal_muscle_electrophysio	2.10723425
18	MP0005083_abnormal_biliary_tract	2.08590693
19	MP0001545_abnormal_hematopoietic_system	2.06841153
20	MP0005397_hematopoietic_system_phenotyp	2.06841153
21	MP0010307_abnormal_tumor_latency	1.87681747
22	MP0001730_embryonic_growth_arrest	1.87612521
23	MP0004233_abnormal_muscle_weight	1.85872865
24	MP0000350_abnormal_cell_proliferation	1.72491542
25	MP0003718_maternal_effect	1.67941810
26	MP0001697_abnormal_embryo_size	1.64056399
27	MP0002396_abnormal_hematopoietic_system	1.63850471
28	MP0006035_abnormal_mitochondrial_morpho	1.55005471
29	MP0001661_extended_life_span	1.53213375
30	MP0002080_prenatal_lethality	1.49617236
31	MP0009278_abnormal_bone_marrow	1.48894268
32	MP0005380_embryogenesis_phenotype	1.48380239
33	MP0001672_abnormal_embryogenesis/_devel	1.48380239
34	MP0002132_abnormal_respiratory_system	1.48341868
35	MP0006036_abnormal_mitochondrial_physio	1.44330388
36	MP0000313_abnormal_cell_death	1.42044429
37	MP0003984_embryonic_growth_retardation	1.37809867
38	MP0002877_abnormal_melanocyte_morpholog	1.37731095
39	MP0002088_abnormal_embryonic_growth/wei	1.32444603
40	MP0002086_abnormal_extraembryonic_tissu	1.31880376
41	MP0001929_abnormal_gametogenesis	1.31288964
42	MP0003959_abnormal_lean_body	1.29355907
43	MP0002009_preneoplasia	1.28692442
44	MP0003221_abnormal_cardiomyocyte_apopto	1.28655205
45	MP0002210_abnormal_sex_determination	1.28431346
46	MP0001727_abnormal_embryo_implantation	1.22029848
47	MP0000372_irregular_coat_pigmentation	1.17348446
48	MP0008775_abnormal_heart_ventricle	1.16411519
49	MP0003385_abnormal_body_wall	1.14062069
50	MP0004808_abnormal_hematopoietic_stem	1.12623058
51	MP0003186_abnormal_redox_activity	1.11361213
52	MP0005636_abnormal_mineral_homeostasis	1.11081833
53	MP0002084_abnormal_developmental_patter	1.10638890
54	MP0005076_abnormal_cell_differentiation	1.09440896
55	MP0002249_abnormal_larynx_morphology	1.08690936
56	MP0002085_abnormal_embryonic_tissue	1.04085827
57	MP0000703_abnormal_thymus_morphology	1.03038201
58	MP0003705_abnormal_hypodermis_morpholog	1.02069311
59	MP0002019_abnormal_tumor_incidence	1.01687679
60	MP0003890_abnormal_embryonic-extraembry	1.01090363
61	MP0002269_muscular_atrophy	1.00801542
62	MP0002139_abnormal_hepatobiliary_system	0.98247809
63	MP0005408_hypopigmentation	0.95440661
64	MP0000358_abnormal_cell_content/	0.95147597
65	MP0004084_abnormal_cardiac_muscle	0.94509818
66	MP0005171_absent_coat_pigmentation	0.94442072
67	MP0003698_abnormal_male_reproductive	0.92879045
68	MP0001873_stomach_inflammation	0.91345432
69	MP0003806_abnormal_nucleotide_metabolis	0.89966316
70	MP0003950_abnormal_plasma_membrane	0.88777499
71	MP0001145_abnormal_male_reproductive	0.88732381
72	MP0003567_abnormal_fetal_cardiomyocyte	0.83995968
73	MP0003699_abnormal_female_reproductive	0.83358084
74	MP0000653_abnormal_sex_gland	0.83267023
75	MP0000609_abnormal_liver_physiology	0.82732289
76	MP0004197_abnormal_fetal_growth/weight/	0.81427319
77	MP0008770_decreased_survivor_rate	0.80168105
78	MP0000747_muscle_weakness	0.79585579
79	MP0002722_abnormal_immune_system	0.78820839
80	MP0001881_abnormal_mammary_gland	0.77530499
81	MP0009703_decreased_birth_body	0.77460352
82	MP0005410_abnormal_fertilization	0.75951011
83	MP0009672_abnormal_birth_weight	0.75447508
84	MP0002161_abnormal_fertility/fecundity	0.74183719
85	MP0003937_abnormal_limbs/digits/tail_de	0.73653552
86	MP0000428_abnormal_craniofacial_morphol	0.72838288
87	MP0004134_abnormal_chest_morphology	0.71363439
88	MP0000647_abnormal_sebaceous_gland	0.70542091
89	MP0010630_abnormal_cardiac_muscle	0.70199598
90	MP0002398_abnormal_bone_marrow	0.70049270
91	MP0006292_abnormal_olfactory_placode	0.68394966
92	MP0009931_abnormal_skin_appearance	0.66207905
93	MP0009115_abnormal_fat_cell	0.65311094
94	MP0001529_abnormal_vocalization	0.65017896
95	MP0010352_gastrointestinal_tract_polyps	0.64564954
96	MP0000598_abnormal_liver_morphology	0.61818365
97	MP0000266_abnormal_heart_morphology	0.61749618
98	MP0003942_abnormal_urinary_system	0.60909412
99	MP0000681_abnormal_thyroid_gland	0.60623404
100	MP0002970_abnormal_white_adipose	0.59267980

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Cholecystitis (HP:0001082)	8.02935615
2	Abnormal gallbladder physiology (HP:0012438)	8.02935615
3	Truncus arteriosus (HP:0001660)	6.82300035
4	Reticulocytosis (HP:0001923)	5.91552813
5	Hyperthyroidism (HP:0000836)	5.31307009
6	Polycythemia (HP:0001901)	5.25150538
7	Ankyloglossia (HP:0010296)	5.15374806
8	Abnormality of reticulocytes (HP:0004312)	4.90340500
9	Bowel incontinence (HP:0002607)	4.66803808
10	Abnormal large intestine physiology (HP:0012700)	4.44958349
11	Birth length less than 3rd percentile (HP:0003561)	4.36796062
12	Cortical dysplasia (HP:0002539)	4.22913085
13	Abnormality of homocysteine metabolism (HP:0010919)	4.09350523
14	Homocystinuria (HP:0002156)	4.09350523
15	Hypertensive crisis (HP:0100735)	4.08932949
16	Cholelithiasis (HP:0001081)	3.91125510
17	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.87892936
18	Abnormal hemoglobin (HP:0011902)	3.87848592
19	Ileus (HP:0002595)	3.80586060
20	Abnormality of oral frenula (HP:0000190)	3.67613930
21	Chromsome breakage (HP:0040012)	3.66472476
22	Seborrheic dermatitis (HP:0001051)	3.65497030
23	Abnormality of glycolysis (HP:0004366)	3.56815392
24	Abnormal gallbladder morphology (HP:0012437)	3.49607733
25	Acute myeloid leukemia (HP:0004808)	3.45766629
26	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.44649267
27	Upper limb muscle weakness (HP:0003484)	3.44003577
28	Poikilocytosis (HP:0004447)	3.41096329
29	Increased serum pyruvate (HP:0003542)	3.31677389
30	Abnormality of cochlea (HP:0000375)	3.28471576
31	Hypoparathyroidism (HP:0000829)	3.27816530
32	Abnormality of the tricuspid valve (HP:0001702)	3.21421324
33	Atelectasis (HP:0100750)	3.12864459
34	Pallor (HP:0000980)	3.07855825
35	Nonimmune hydrops fetalis (HP:0001790)	2.83520079
36	Abnormality of the gallbladder (HP:0005264)	2.81464374
37	Flat cornea (HP:0007720)	2.80556643
38	Reticulocytopenia (HP:0001896)	2.76670061
39	Hyperbilirubinemia (HP:0002904)	2.68137019
40	Peripheral hypomyelination (HP:0007182)	2.67476759
41	Acanthocytosis (HP:0001927)	2.66840820
42	Orthostatic hypotension (HP:0001278)	2.54760440
43	Aplasia/Hypoplasia of the earlobes (HP:0009906)	2.53311884
44	Morphological abnormality of the inner ear (HP:0011390)	2.47813720
45	Increased nuchal translucency (HP:0010880)	2.46645666
46	Abnormally folded helix (HP:0008544)	2.46547883
47	Tinnitus (HP:0000360)	2.45628752
48	Overlapping toe (HP:0001845)	2.45002713
49	Disproportionate tall stature (HP:0001519)	2.43850222
50	Sandal gap (HP:0001852)	2.37384700
51	Myelodysplasia (HP:0002863)	2.34502516
52	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.34153382
53	Aplasia/Hypoplasia of the thymus (HP:0010515)	2.27732544
54	Obsessive-compulsive behavior (HP:0000722)	2.24381843
55	Duplicated collecting system (HP:0000081)	2.22385688
56	Cheekbone underdevelopment (HP:0010669)	2.21245609
57	Dysmetric saccades (HP:0000641)	2.16403879
58	Breech presentation (HP:0001623)	2.15161405
59	Insomnia (HP:0100785)	2.13362608
60	Attention deficit hyperactivity disorder (HP:0007018)	2.12581224
61	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.08621484
62	Abnormality of cells of the erythroid lineage (HP:0012130)	2.08323066
63	Patellar dislocation (HP:0002999)	2.03465950
64	Short middle phalanx of the 5th finger (HP:0004220)	2.02496047
65	Venous insufficiency (HP:0005293)	2.01873350
66	Abnormality of the fingertips (HP:0001211)	1.96938813
67	Macrocytic anemia (HP:0001972)	1.95488897
68	Abnormal number of erythroid precursors (HP:0012131)	1.94195924
69	Breast hypoplasia (HP:0003187)	1.85474644
70	Abnormality of the renal collecting system (HP:0004742)	1.83001582
71	Overfolded helix (HP:0000396)	1.82736944
72	Duodenal stenosis (HP:0100867)	1.80907868
73	Small intestinal stenosis (HP:0012848)	1.80907868
74	Pheochromocytoma (HP:0002666)	1.76018883
75	Cafe-au-lait spot (HP:0000957)	1.73953792
76	Relative macrocephaly (HP:0004482)	1.72870696
77	Abnormality of the preputium (HP:0100587)	1.71479900
78	Ventricular fibrillation (HP:0001663)	1.69376073
79	Angiofibromas (HP:0010615)	1.68375275
80	Adenoma sebaceum (HP:0009720)	1.68375275
81	Septate vagina (HP:0001153)	1.66502560
82	Abnormality of chromosome stability (HP:0003220)	1.65831812
83	Venous abnormality (HP:0002624)	1.64260580
84	Abnormality of DNA repair (HP:0003254)	1.63269080
85	Limb hypertonia (HP:0002509)	1.63189371
86	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.61313664
87	Esophageal neoplasm (HP:0100751)	1.59117249
88	Neoplasm of head and neck (HP:0012288)	1.59117249
89	Chronic obstructive pulmonary disease (HP:0006510)	1.58915389
90	Obstructive lung disease (HP:0006536)	1.58915389
91	Hammertoe (HP:0001765)	1.58102570
92	Increased connective tissue (HP:0009025)	1.57135405
93	Fatigue (HP:0012378)	1.57066333
94	Palpitations (HP:0001962)	1.56509309
95	Gastrointestinal dysmotility (HP:0002579)	1.56201339
96	Abnormality of the thymus (HP:0000777)	1.53477488
97	Insidious onset (HP:0003587)	1.52022521
98	Termporal pattern (HP:0011008)	1.52022521
99	Thin ribs (HP:0000883)	1.51576759
100	Redundant skin (HP:0001582)	1.48662297

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK4	4.94015299
2	EIF2AK1	4.09483924
3	KSR2	4.02680366
4	TTK	3.77049090
5	EEF2K	3.24848158
6	CLK1	3.04796895
7	BMPR2	2.90767841
8	MAP3K2	2.90242103
9	NTRK3	2.85984299
10	RAF1	2.82390170
11	CDC7	2.45925436
12	KSR1	2.31225909
13	WEE1	2.23182887
14	BRSK2	2.04377094
15	NEK1	2.00241206
16	PLK4	1.96018699
17	CCNB1	1.87810055
18	SRPK1	1.80998562
19	NME1	1.78679631
20	BUB1	1.73266257
21	NEK2	1.72190537
22	TSSK6	1.62276269
23	MAP3K8	1.57966150
24	ICK	1.41200196
25	BMX	1.40835823
26	CDK12	1.38157534
27	CHEK2	1.32457585
28	EIF2AK3	1.28956932
29	PBK	1.28599243
30	RPS6KB2	1.28257753
31	SCYL2	1.28195908
32	TRPM7	1.22776195
33	MAP3K4	1.10824840
34	PLK3	1.03320712
35	ATR	1.02106438
36	JAK2	1.01721354
37	BRSK1	1.01583668
38	STK3	0.99483502
39	ALK	0.94121172
40	IRAK3	0.93724252
41	CHEK1	0.91826549
42	BRAF	0.89378431
43	STK4	0.87956375
44	RET	0.84437021
45	PASK	0.83093864
46	PDK2	0.82999719
47	CDK1	0.78626492
48	MAPKAPK5	0.78533134
49	ATM	0.76101643
50	MKNK1	0.76014441
51	WNK4	0.73783451
52	MAP2K1	0.73438941
53	MST4	0.72869416
54	CDK2	0.71995224
55	WNK1	0.71591416
56	TNIK	0.70923944
57	MAP3K1	0.69144061
58	PLK1	0.68268685
59	YES1	0.66734347
60	PIK3CG	0.64230160
61	PAK1	0.63039718
62	JAK3	0.55452285
63	PIM1	0.54764910
64	AURKB	0.53678888
65	MTOR	0.53501558
66	MARK3	0.51170316
67	MAP3K6	0.50984299
68	BRD4	0.50885741
69	TEC	0.47323863
70	CSNK1E	0.46239834
71	CSNK2A2	0.44250784
72	PTK6	0.43509821
73	MAP3K7	0.41307615
74	DYRK3	0.40842768
75	CDK7	0.38873696
76	MAPK10	0.38630934
77	PAK2	0.38581663
78	BTK	0.38316963
79	STK10	0.37983986
80	EPHA3	0.36556828
81	LATS2	0.36245736
82	TYRO3	0.35024658
83	TRIB3	0.33870146
84	LRRK2	0.33535809
85	AKT3	0.33505989
86	GSK3B	0.33421930
87	CDK4	0.32982997
88	PRKDC	0.31905527
89	EIF2AK2	0.31669350
90	CSNK2A1	0.30995856
91	NME2	0.30929801
92	DMPK	0.30057487
93	SGK1	0.29813760
94	PRPF4B	0.29662043
95	MAPK14	0.29496913
96	MAP3K10	0.28333807
97	PRKG2	0.26006826
98	PRKAA1	0.25658047
99	RPS6KA4	0.25477693
100	ILK	0.25252257

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	4.80105464
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	4.75549258
3	One carbon pool by folate_Homo sapiens_hsa00670	3.50654787
4	Mismatch repair_Homo sapiens_hsa03430	3.30036087
5	DNA replication_Homo sapiens_hsa03030	3.25600918
6	Homologous recombination_Homo sapiens_hsa03440	2.70638096
7	RNA transport_Homo sapiens_hsa03013	2.45602637
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.41614833
9	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.36042442
10	Spliceosome_Homo sapiens_hsa03040	2.26070696
11	Cell cycle_Homo sapiens_hsa04110	2.25309504
12	Ribosome_Homo sapiens_hsa03010	2.02205033
13	Nucleotide excision repair_Homo sapiens_hsa03420	1.98469292
14	Pyruvate metabolism_Homo sapiens_hsa00620	1.87417580
15	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.81950957
16	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.79475379
17	Fanconi anemia pathway_Homo sapiens_hsa03460	1.75490356
18	Carbon metabolism_Homo sapiens_hsa01200	1.71439054
19	Steroid biosynthesis_Homo sapiens_hsa00100	1.68742088
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.67991336
21	Basal transcription factors_Homo sapiens_hsa03022	1.61566605
22	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.61498351
23	Acute myeloid leukemia_Homo sapiens_hsa05221	1.59970761
24	Chronic myeloid leukemia_Homo sapiens_hsa05220	1.39744406
25	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.35778773
26	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.25778111
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.25403501
28	RNA degradation_Homo sapiens_hsa03018	1.24987788
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.22277811
30	Base excision repair_Homo sapiens_hsa03410	1.20954243
31	Thyroid cancer_Homo sapiens_hsa05216	1.18929249
32	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.15910085
33	Type II diabetes mellitus_Homo sapiens_hsa04930	1.15284456
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.14478965
35	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.12184224
36	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.10932475
37	Olfactory transduction_Homo sapiens_hsa04740	1.06617241
38	mTOR signaling pathway_Homo sapiens_hsa04150	1.04315969
39	Oocyte meiosis_Homo sapiens_hsa04114	1.02947196
40	VEGF signaling pathway_Homo sapiens_hsa04370	0.98322582
41	ErbB signaling pathway_Homo sapiens_hsa04012	0.96659365
42	Pentose phosphate pathway_Homo sapiens_hsa00030	0.94308549
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.92933096
44	Renal cell carcinoma_Homo sapiens_hsa05211	0.92069622
45	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.89971913
46	RNA polymerase_Homo sapiens_hsa03020	0.89354827
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.87301136
48	Pancreatic cancer_Homo sapiens_hsa05212	0.87162393
49	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.84063851
50	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.83845608
51	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.83511770
52	Non-small cell lung cancer_Homo sapiens_hsa05223	0.83495534
53	Propanoate metabolism_Homo sapiens_hsa00640	0.82501473
54	Arginine biosynthesis_Homo sapiens_hsa00220	0.80739829
55	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.76401401
56	Viral carcinogenesis_Homo sapiens_hsa05203	0.76178737
57	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.75976731
58	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.73032359
59	Insulin signaling pathway_Homo sapiens_hsa04910	0.69174218
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.66601367
61	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65692204
62	Purine metabolism_Homo sapiens_hsa00230	0.64316835
63	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62825104
64	Butanoate metabolism_Homo sapiens_hsa00650	0.62472064
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60743196
66	MicroRNAs in cancer_Homo sapiens_hsa05206	0.57870513
67	Prion diseases_Homo sapiens_hsa05020	0.57330139
68	Fatty acid metabolism_Homo sapiens_hsa01212	0.55212255
69	Proteasome_Homo sapiens_hsa03050	0.55104853
70	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.54301720
71	Prolactin signaling pathway_Homo sapiens_hsa04917	0.54141183
72	Parkinsons disease_Homo sapiens_hsa05012	0.52195749
73	Glioma_Homo sapiens_hsa05214	0.48997068
74	Protein export_Homo sapiens_hsa03060	0.48530109
75	Huntingtons disease_Homo sapiens_hsa05016	0.47380687
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.42452423
77	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.39694778
78	Bladder cancer_Homo sapiens_hsa05219	0.39273315
79	Hepatitis B_Homo sapiens_hsa05161	0.39095816
80	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.37691883
81	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.34836855
82	Shigellosis_Homo sapiens_hsa05131	0.33757814
83	Colorectal cancer_Homo sapiens_hsa05210	0.33189362
84	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.31036624
85	Lysine degradation_Homo sapiens_hsa00310	0.30799184
86	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.27629688
87	Oxidative phosphorylation_Homo sapiens_hsa00190	0.27251175
88	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.26460313
89	Endometrial cancer_Homo sapiens_hsa05213	0.26329923
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.25440314
91	Metabolic pathways_Homo sapiens_hsa01100	0.24792294
92	Choline metabolism in cancer_Homo sapiens_hsa05231	0.23841551
93	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.23341986
94	Long-term potentiation_Homo sapiens_hsa04720	0.22170039
95	Fatty acid elongation_Homo sapiens_hsa00062	0.21462105
96	Other glycan degradation_Homo sapiens_hsa00511	0.19139050
97	Glutathione metabolism_Homo sapiens_hsa00480	0.18976600
98	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.17355047
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.15949296
100	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.14676223

ABCB10P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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