ABCB11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)9.86342150
2L-phenylalanine catabolic process (GO:0006559)7.62432659
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.62432659
4L-phenylalanine metabolic process (GO:0006558)7.25993733
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.25993733
6aromatic amino acid family catabolic process (GO:0009074)6.88334595
7drug metabolic process (GO:0017144)6.68866253
8oxidative demethylation (GO:0070989)6.45664976
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.25004100
10indole-containing compound catabolic process (GO:0042436)6.24473010
11indolalkylamine catabolic process (GO:0046218)6.24473010
12tryptophan catabolic process (GO:0006569)6.24473010
13kynurenine metabolic process (GO:0070189)6.11617885
14tryptophan metabolic process (GO:0006568)5.87917700
15* bile acid biosynthetic process (GO:0006699)5.83000976
16glyoxylate metabolic process (GO:0046487)5.78335750
17urea metabolic process (GO:0019627)5.74076056
18urea cycle (GO:0000050)5.74076056
19alpha-linolenic acid metabolic process (GO:0036109)5.67753052
20negative regulation of fibrinolysis (GO:0051918)5.66014804
21high-density lipoprotein particle remodeling (GO:0034375)5.48889126
22complement activation, alternative pathway (GO:0006957)5.48129338
23regulation of protein activation cascade (GO:2000257)5.47087070
24regulation of fibrinolysis (GO:0051917)5.46487224
25cysteine metabolic process (GO:0006534)5.43177212
26peptidyl-glutamic acid carboxylation (GO:0017187)5.41229476
27protein carboxylation (GO:0018214)5.41229476
28sulfur amino acid catabolic process (GO:0000098)5.38355682
29killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.34788762
30disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.34788762
31regulation of humoral immune response (GO:0002920)5.33169162
32positive regulation of heterotypic cell-cell adhesion (GO:0034116)5.32070531
33negative regulation of protein activation cascade (GO:2000258)5.29964009
34nitrogen cycle metabolic process (GO:0071941)5.27321627
35serine family amino acid catabolic process (GO:0009071)5.15885563
36regulation of complement activation (GO:0030449)5.10693162
37regulation of plasminogen activation (GO:0010755)5.07032712
38* bile acid metabolic process (GO:0008206)5.00364091
39aromatic amino acid family metabolic process (GO:0009072)4.99346129
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.94460441
41acute-phase response (GO:0006953)4.89666294
42homocysteine metabolic process (GO:0050667)4.87657460
43ethanol metabolic process (GO:0006067)4.86099345
44tyrosine metabolic process (GO:0006570)4.82370715
45reverse cholesterol transport (GO:0043691)4.80442450
46regulation of triglyceride catabolic process (GO:0010896)4.75377438
47regulation of cholesterol esterification (GO:0010872)4.75336228
48protein-lipid complex remodeling (GO:0034368)4.74140924
49macromolecular complex remodeling (GO:0034367)4.74140924
50plasma lipoprotein particle remodeling (GO:0034369)4.74140924
51alpha-amino acid catabolic process (GO:1901606)4.67577525
52S-adenosylmethionine metabolic process (GO:0046500)4.66452197
53triglyceride homeostasis (GO:0070328)4.61707701
54acylglycerol homeostasis (GO:0055090)4.61707701
55phenylpropanoid metabolic process (GO:0009698)4.61341817
56amino-acid betaine metabolic process (GO:0006577)4.59395342
57lysine catabolic process (GO:0006554)4.58756999
58lysine metabolic process (GO:0006553)4.58756999
59negative regulation of blood coagulation (GO:0030195)4.53241620
60negative regulation of hemostasis (GO:1900047)4.53241620
61negative regulation of sterol transport (GO:0032372)4.51029069
62negative regulation of cholesterol transport (GO:0032375)4.51029069
63phospholipid efflux (GO:0033700)4.49903300
64glycine metabolic process (GO:0006544)4.48227935
65imidazole-containing compound metabolic process (GO:0052803)4.46586237
66indolalkylamine metabolic process (GO:0006586)4.43078614
67coenzyme catabolic process (GO:0009109)4.42351647
68cellular ketone body metabolic process (GO:0046950)4.40695211
69plasma lipoprotein particle clearance (GO:0034381)4.37628772
70flavonoid metabolic process (GO:0009812)4.35317493
71cellular biogenic amine catabolic process (GO:0042402)4.33350246
72amine catabolic process (GO:0009310)4.33350246
73cellular amino acid catabolic process (GO:0009063)4.29658998
74cellular glucuronidation (GO:0052695)4.28787415
75glutamate metabolic process (GO:0006536)4.28591308
76alkaloid metabolic process (GO:0009820)4.26156052
77serine family amino acid metabolic process (GO:0009069)4.22189452
78cholesterol efflux (GO:0033344)4.22106823
79* bile acid and bile salt transport (GO:0015721)4.19353992
80ethanol oxidation (GO:0006069)4.17885787
81benzene-containing compound metabolic process (GO:0042537)4.15708985
82dicarboxylic acid biosynthetic process (GO:0043650)4.10478566
83negative regulation of coagulation (GO:0050819)4.09968047
84low-density lipoprotein particle remodeling (GO:0034374)4.09179551
85negative regulation of wound healing (GO:0061045)4.08890253
86negative regulation of complement activation (GO:0045916)4.08745270
87cellular modified amino acid catabolic process (GO:0042219)4.08457643
88serine family amino acid biosynthetic process (GO:0009070)4.06801382
89hormone catabolic process (GO:0042447)4.04859595
90fibrinolysis (GO:0042730)4.03740170
91plasma lipoprotein particle assembly (GO:0034377)3.99448771
92aldehyde catabolic process (GO:0046185)3.99416616
93arginine metabolic process (GO:0006525)3.98128271
94drug catabolic process (GO:0042737)3.90495327
95blood coagulation, intrinsic pathway (GO:0007597)3.88617396
96complement activation, classical pathway (GO:0006958)3.83701611
97positive regulation of blood coagulation (GO:0030194)3.83381743
98positive regulation of hemostasis (GO:1900048)3.83381743
99very-low-density lipoprotein particle assembly (GO:0034379)3.82007169
100ketone body metabolic process (GO:1902224)3.81469880
101phospholipid homeostasis (GO:0055091)3.81120868
102glucuronate metabolic process (GO:0019585)3.80180473
103uronic acid metabolic process (GO:0006063)3.80180473
104cofactor catabolic process (GO:0051187)3.80099888
105complement activation (GO:0006956)3.79765862
106protein activation cascade (GO:0072376)3.77596192
107cytolysis (GO:0019835)3.74859155
108carboxylic acid catabolic process (GO:0046395)3.74800784
109organic acid catabolic process (GO:0016054)3.74800784
110cholesterol homeostasis (GO:0042632)3.73968106
111regulation of bile acid biosynthetic process (GO:0070857)3.73631025
112acetyl-CoA metabolic process (GO:0006084)3.73406122
113positive regulation of lipid catabolic process (GO:0050996)3.71255158
114positive regulation of triglyceride lipase activity (GO:0061365)3.70863187
115positive regulation of lipoprotein lipase activity (GO:0051006)3.70863187
116regulation of cholesterol homeostasis (GO:2000188)3.68430770
117regulation of acute inflammatory response (GO:0002673)3.68344605
118sodium-independent organic anion transport (GO:0043252)3.67895232
119sterol homeostasis (GO:0055092)3.67704704
120short-chain fatty acid metabolic process (GO:0046459)3.66369844
121negative regulation of lipase activity (GO:0060192)3.64402417
122response to mercury ion (GO:0046689)3.61820292
123plasma lipoprotein particle organization (GO:0071827)3.60788371
124acute inflammatory response (GO:0002526)3.59043192
125protein-lipid complex assembly (GO:0065005)3.58054118
126opsonization (GO:0008228)3.56175201
127regulation of apoptotic cell clearance (GO:2000425)3.55226957
128NAD biosynthetic process (GO:0009435)3.53228851
129positive regulation of coagulation (GO:0050820)3.51673720
130xenobiotic metabolic process (GO:0006805)3.47106487
131intestinal cholesterol absorption (GO:0030299)3.46823384
132arginine catabolic process (GO:0006527)3.36906156
133positive regulation of fatty acid biosynthetic process (GO:0045723)3.36680207
134oxaloacetate metabolic process (GO:0006107)3.34023651
135drug transmembrane transport (GO:0006855)3.32198371
136exogenous drug catabolic process (GO:0042738)11.1580596
137omega-hydroxylase P450 pathway (GO:0097267)10.4065301

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.41714627
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19776105
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.09933317
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.54046043
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30927770
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.11361436
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.69230455
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.10684678
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02383329
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.08118347
11* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9093705
12HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.96110853
13TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92340151
14FOXA2_19822575_ChIP-Seq_HepG2_Human1.64193601
15CLOCK_20551151_ChIP-Seq_293T_Human1.53292045
16* HTT_18923047_ChIP-ChIP_STHdh_Human1.48917122
17GATA1_22025678_ChIP-Seq_K562_Human1.44405235
18* HNF4A_19822575_ChIP-Seq_HepG2_Human1.41332633
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21655006
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20084350
21RXRA_24833708_ChIP-Seq_LIVER_Mouse1.20055450
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18017990
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08265238
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.07421832
25ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07084139
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.05656333
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03484216
28PHF8_20622853_ChIP-Seq_HELA_Human1.02513178
29CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02064612
30HNFA_21074721_ChIP-Seq_CACO-2_Human0.99705764
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99251271
32ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98640933
33NFYA_21822215_ChIP-Seq_K562_Human0.97737266
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96656242
35ER_23166858_ChIP-Seq_MCF-7_Human0.96037635
36MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95669593
37EZH2_27294783_Chip-Seq_NPCs_Mouse0.94877912
38SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92742542
39TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.87849115
40IRF1_19129219_ChIP-ChIP_H3396_Human0.87124700
41IRF8_22096565_ChIP-ChIP_GC-B_Human0.86173140
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84897461
43TP53_18474530_ChIP-ChIP_U2OS_Human0.84642392
44SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84618180
45TCF4_18268006_ChIP-ChIP_LS174T_Human0.83757108
46GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83507335
47ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83149361
48AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83007102
49GATA6_21074721_ChIP-Seq_CACO-2_Human0.82933464
50GATA4_25053715_ChIP-Seq_YYC3_Human0.80971242
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.79056470
52RARG_19884340_ChIP-ChIP_MEFs_Mouse0.78532438
53KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78050179
54CBX2_22325352_ChIP-Seq_293T-Rex_Human0.77191544
55BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77182235
56SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77014689
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76047674
58Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75938342
59ZNF263_19887448_ChIP-Seq_K562_Human0.74528529
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74375298
61TRIM28_21343339_ChIP-Seq_HEK293_Human0.74133040
62CRX_20693478_ChIP-Seq_RETINA_Mouse0.73947039
63RARA_24833708_ChIP-Seq_LIVER_Mouse0.73699575
64ETV1_20927104_ChIP-Seq_GIST48_Human0.72985857
65NFYB_21822215_ChIP-Seq_K562_Human0.72136639
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71448375
67SALL4_18804426_ChIP-ChIP_XEN_Mouse0.69663689
68ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69380324
69NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.68541267
70NRF2_20460467_ChIP-Seq_MEFs_Mouse0.68541267
71ETV2_25802403_ChIP-Seq_MESCs_Mouse0.67842170
72OCT4_21477851_ChIP-Seq_ESCs_Mouse0.67692185
73ESR2_21235772_ChIP-Seq_MCF-7_Human0.67393044
74* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67107872
75GBX2_23144817_ChIP-Seq_PC3_Human0.65423641
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.65100680
77CBP_20019798_ChIP-Seq_JUKART_Human0.65100680
78IGF1R_20145208_ChIP-Seq_DFB_Human0.64717859
79PCGF2_27294783_Chip-Seq_NPCs_Mouse0.64516265
80STAT3_23295773_ChIP-Seq_U87_Human0.64320711
81PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.63568291
82* OCT4_18555785_Chip-Seq_ESCs_Mouse0.63285511
83RARB_24833708_ChIP-Seq_LIVER_Mouse0.63129238
84CTBP1_25329375_ChIP-Seq_LNCAP_Human0.62505354
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61869786
86ERG_20517297_ChIP-Seq_VCAP_Human0.60732393
87RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59424038
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.59001234
89SMAD1_18555785_Chip-Seq_ESCs_Mouse0.58682532
90KLF5_20875108_ChIP-Seq_MESCs_Mouse0.58350425
91BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58214741
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.57757927
93NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.57530550
94TBL1_22424771_ChIP-Seq_293T_Human0.57202336
95CEBPB_22108803_ChIP-Seq_LS180_Human0.56915857
96ESRRB_18555785_Chip-Seq_ESCs_Mouse0.56785163
97NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.56676992
98LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.56431180
99TAF15_26573619_Chip-Seq_HEK293_Human0.55676228
100FOXA1_25552417_ChIP-Seq_VCAP_Human0.54916535
101EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.54636247
102EGR1_19032775_ChIP-ChIP_M12_Human0.54610365
103SOX2_21211035_ChIP-Seq_LN229_Human0.54271474
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.53851660
105DROSHA_22980978_ChIP-Seq_HELA_Human0.52964585
106FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.52723331
107MYC_19915707_ChIP-ChIP_AK7_Human0.51771624
108TCF4_22108803_ChIP-Seq_LS180_Human0.51484411
109AR_20517297_ChIP-Seq_VCAP_Human0.51337567
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51315570
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.49850708
112ESET_19884257_ChIP-Seq_ESCs_Mouse0.49743070
113CBP_21632823_ChIP-Seq_H3396_Human0.49587079
114STAT3_1855785_ChIP-Seq_MESCs_Mouse0.49292720
115LXR_22292898_ChIP-Seq_THP-1_Human0.48499495
116* STAT1_17558387_ChIP-Seq_HELA_Human0.46922865
117E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46325117
118PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46256950
119P53_21459846_ChIP-Seq_SAOS-2_Human0.46239493
120ESR1_21235772_ChIP-Seq_MCF-7_Human0.45931065
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.44845602
122CDX2_20551321_ChIP-Seq_CACO-2_Human0.44016337
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43881642
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.43164784
125FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.42872074
126BCAT_22108803_ChIP-Seq_LS180_Human0.42821622
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.42305958
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.41049334
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.40887030
130TAF2_19829295_ChIP-Seq_ESCs_Human0.40781339
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.39433659
132GATA6_25053715_ChIP-Seq_YYC3_Human0.38628433
133SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38295509
134STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.37820251
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.37063566
136* GATA2_19941826_ChIP-Seq_K562_Human0.37015754
137MYC_27129775_Chip-Seq_CORNEA_Mouse0.36904450
138* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.36721713
139LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.36178887
140* GATA1_19941826_ChIP-Seq_K562_Human0.35556052
141SPI1_26923725_Chip-Seq_HPCs_Mouse0.34828904
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.34553276
143NCOR_22424771_ChIP-Seq_293T_Human0.34526188
144FOXH1_21741376_ChIP-Seq_EPCs_Human0.34296985
145CDX2_22108803_ChIP-Seq_LS180_Human0.34116045
146* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.33360160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.44541921
2MP0005360_urolithiasis7.67580079
3* MP0005085_abnormal_gallbladder_physiolo6.29404036
4* MP0005365_abnormal_bile_salt5.97951150
5MP0008875_abnormal_xenobiotic_pharmacok5.13136792
6MP0003806_abnormal_nucleotide_metabolis4.37912954
7MP0010329_abnormal_lipoprotein_level3.63818850
8* MP0003252_abnormal_bile_duct3.58157497
9MP0009840_abnormal_foam_cell3.22632595
10MP0005083_abnormal_biliary_tract3.17154423
11MP0003195_calcinosis2.89152973
12MP0005332_abnormal_amino_acid2.75952262
13MP0001666_abnormal_nutrient_absorption2.62990332
14MP0003191_abnormal_cellular_cholesterol2.25888410
15* MP0000609_abnormal_liver_physiology2.17131670
16MP0004019_abnormal_vitamin_homeostasis2.14650415
17* MP0002118_abnormal_lipid_homeostasis2.09913987
18MP0002138_abnormal_hepatobiliary_system2.00785504
19MP0003868_abnormal_feces_composition1.95656288
20MP0005319_abnormal_enzyme/_coenzyme1.84792054
21MP0001764_abnormal_homeostasis1.67487109
22MP0009697_abnormal_copulation1.66999612
23MP0005584_abnormal_enzyme/coenzyme_acti1.57822542
24MP0003011_delayed_dark_adaptation1.39515000
25MP0005451_abnormal_body_composition1.38815963
26MP0002132_abnormal_respiratory_system1.33001787
27MP0003186_abnormal_redox_activity1.26194301
28MP0003656_abnormal_erythrocyte_physiolo1.24312732
29MP0009643_abnormal_urine_homeostasis1.22185667
30MP0003705_abnormal_hypodermis_morpholog1.16932833
31MP0005647_abnormal_sex_gland1.16832776
32* MP0000598_abnormal_liver_morphology1.16615869
33MP0000604_amyloidosis1.09017000
34MP0002254_reproductive_system_inflammat1.07022627
35MP0009764_decreased_sensitivity_to1.06192785
36MP0009763_increased_sensitivity_to1.03230021
37MP0010368_abnormal_lymphatic_system0.97847212
38MP0002282_abnormal_trachea_morphology0.96663824
39MP0005636_abnormal_mineral_homeostasis0.92395711
40MP0005187_abnormal_penis_morphology0.91912962
41MP0008469_abnormal_protein_level0.89587691
42MP0005408_hypopigmentation0.89020153
43MP0001915_intracranial_hemorrhage0.88417211
44MP0009642_abnormal_blood_homeostasis0.87579483
45MP0005084_abnormal_gallbladder_morpholo0.83170235
46MP0006036_abnormal_mitochondrial_physio0.80979847
47MP0005376_homeostasis/metabolism_phenot0.80324586
48MP0009765_abnormal_xenobiotic_induced0.79057645
49MP0002876_abnormal_thyroid_physiology0.76737956
50MP0005220_abnormal_exocrine_pancreas0.76711122
51* MP0002078_abnormal_glucose_homeostasis0.76322331
52MP0002249_abnormal_larynx_morphology0.74889992
53MP0005670_abnormal_white_adipose0.73673853
54MP0002971_abnormal_brown_adipose0.72601080
55MP0001661_extended_life_span0.71544814
56MP0005334_abnormal_fat_pad0.70529594
57MP0004130_abnormal_muscle_cell0.69555522
58MP0003690_abnormal_glial_cell0.68439633
59MP0005535_abnormal_body_temperature0.68382351
60MP0005266_abnormal_metabolism0.65308699
61MP0009053_abnormal_anal_canal0.64978669
62MP0003329_amyloid_beta_deposits0.63129386
63MP0003879_abnormal_hair_cell0.62603369
64MP0005023_abnormal_wound_healing0.62260588
65MP0000639_abnormal_adrenal_gland0.61949161
66MP0006035_abnormal_mitochondrial_morpho0.59320391
67MP0001756_abnormal_urination0.57721604
68MP0005448_abnormal_energy_balance0.56917311
69MP0005464_abnormal_platelet_physiology0.53938733
70MP0002928_abnormal_bile_duct0.50398080
71MP0002332_abnormal_exercise_endurance0.49481137
72MP0005395_other_phenotype0.49357838
73MP0002822_catalepsy0.49172907
74MP0003718_maternal_effect0.46603199
75MP0004381_abnormal_hair_follicle0.46547869
76MP0003638_abnormal_response/metabolism_0.45154636
77MP0003724_increased_susceptibility_to0.45001358
78MP0008874_decreased_physiological_sensi0.44850197
79MP0004782_abnormal_surfactant_physiolog0.44563641
80MP0008873_increased_physiological_sensi0.43853911
81MP0002136_abnormal_kidney_physiology0.43848827
82MP0003436_decreased_susceptibility_to0.43787489
83MP0000467_abnormal_esophagus_morphology0.42959775
84MP0002837_dystrophic_cardiac_calcinosis0.42260095
85MP0001851_eye_inflammation0.41736560
86MP0003953_abnormal_hormone_level0.41423065
87MP0005248_abnormal_Harderian_gland0.41282035
88MP0009785_altered_susceptibility_to0.40984403
89MP0003075_altered_response_to0.39752952
90MP0000579_abnormal_nail_morphology0.38719050
91MP0005166_decreased_susceptibility_to0.38145238
92MP0009672_abnormal_birth_weight0.37213979
93MP0005397_hematopoietic_system_phenotyp0.36700988
94MP0001545_abnormal_hematopoietic_system0.36700988
95MP0000566_synostosis0.35932070
96MP0009384_cardiac_valve_regurgitation0.35812708
97MP0008872_abnormal_physiological_respon0.34761955
98MP0005666_abnormal_adipose_tissue0.34534913
99MP0002796_impaired_skin_barrier0.33858083
100MP0006082_CNS_inflammation0.33491033
101MP0009115_abnormal_fat_cell0.31773195
102MP0000249_abnormal_blood_vessel0.31753064
103MP0002168_other_aberrant_phenotype0.31718018
104MP0001853_heart_inflammation0.31662620
105MP0001243_abnormal_dermal_layer0.31188067
106MP0004883_abnormal_blood_vessel0.31175948
107MP0000230_abnormal_systemic_arterial0.31151964
108MP0002970_abnormal_white_adipose0.30353762
109MP0002128_abnormal_blood_circulation0.28903421
110MP0001881_abnormal_mammary_gland0.28322049
111MP0001845_abnormal_inflammatory_respons0.27542783
112MP0000920_abnormal_myelination0.26234930
113MP0000427_abnormal_hair_cycle0.25481586
114MP0005197_abnormal_uvea_morphology0.25462329
115MP0005164_abnormal_response_to0.25350077
116MP0003878_abnormal_ear_physiology0.25268576
117MP0005377_hearing/vestibular/ear_phenot0.25268576
118MP0003632_abnormal_nervous_system0.25195182
119MP0003633_abnormal_nervous_system0.25135676
120MP0002060_abnormal_skin_morphology0.24429239
121MP0005595_abnormal_vascular_smooth0.23571690
122MP0002090_abnormal_vision0.23433414
123MP0004272_abnormal_basement_membrane0.20224272
124MP0003631_nervous_system_phenotype0.19497463
125MP0000371_diluted_coat_color0.19460503

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.57316507
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.44857954
3* Intrahepatic cholestasis (HP:0001406)7.06255982
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75225351
5Prolonged partial thromboplastin time (HP:0003645)6.74028509
6Hypobetalipoproteinemia (HP:0003563)6.59909791
7Xanthomatosis (HP:0000991)6.39051815
8Complement deficiency (HP:0004431)5.59424716
9Hyperlipoproteinemia (HP:0010980)5.56913477
10Joint hemorrhage (HP:0005261)4.91659742
11Hypolipoproteinemia (HP:0010981)4.87409110
12Epidermoid cyst (HP:0200040)4.70058434
13Hyperammonemia (HP:0001987)4.63049750
14Abnormality of the common coagulation pathway (HP:0010990)4.61179953
15Hyperglycinemia (HP:0002154)4.54399355
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.46481526
17Abnormality of methionine metabolism (HP:0010901)4.26170262
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.25732173
19Ketosis (HP:0001946)4.25215783
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17228467
21Hypoalphalipoproteinemia (HP:0003233)4.16597364
22Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10459383
23Abnormality of complement system (HP:0005339)4.07997566
24Abnormality of serine family amino acid metabolism (HP:0010894)3.96733771
25Abnormality of glycine metabolism (HP:0010895)3.96733771
26Hyperglycinuria (HP:0003108)3.94924267
27Hypoglycemic coma (HP:0001325)3.91818388
28* Fat malabsorption (HP:0002630)3.90000834
29Abnormality of the intrinsic pathway (HP:0010989)3.86121544
30Abnormality of pyrimidine metabolism (HP:0004353)3.82834465
31Hypercholesterolemia (HP:0003124)3.71632048
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35698549
33Abnormality of fatty-acid metabolism (HP:0004359)3.30411532
34Steatorrhea (HP:0002570)3.19937765
35Delayed CNS myelination (HP:0002188)3.14444186
36* Hyperbilirubinemia (HP:0002904)3.12955665
37Spontaneous abortion (HP:0005268)3.12284081
38Abnormality of serum amino acid levels (HP:0003112)3.10931054
39Hypochromic microcytic anemia (HP:0004840)3.05174888
40Abnormality of nucleobase metabolism (HP:0010932)3.04517132
41Myocardial infarction (HP:0001658)3.04404099
42Ketoacidosis (HP:0001993)3.03422669
43Skin nodule (HP:0200036)2.91929996
44Osteomalacia (HP:0002749)2.80492460
45Acanthocytosis (HP:0001927)2.79434308
46Systemic lupus erythematosus (HP:0002725)2.79411691
47Metabolic acidosis (HP:0001942)2.74431166
48Abnormality of purine metabolism (HP:0004352)2.65358466
49Neonatal hypoglycemia (HP:0001998)2.64889102
50Vascular calcification (HP:0004934)2.60324938
51Lethargy (HP:0001254)2.59296093
52Hypoglycemic seizures (HP:0002173)2.57056098
53Fair hair (HP:0002286)2.55514622
54Dicarboxylic aciduria (HP:0003215)2.55018127
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.55018127
56Glomerulonephritis (HP:0000099)2.52766247
57Spastic diplegia (HP:0001264)2.47748836
58Pulmonary embolism (HP:0002204)2.47560988
59Mitral stenosis (HP:0001718)2.46427031
60* Hepatocellular carcinoma (HP:0001402)2.44017267
61Recurrent gram-negative bacterial infections (HP:0005420)2.43909318
62Purpura (HP:0000979)2.42989301
63Cerebral edema (HP:0002181)2.41249989
64Gout (HP:0001997)2.40160292
65Abnormal gallbladder physiology (HP:0012438)2.38082778
66Cholecystitis (HP:0001082)2.38082778
67Irritability (HP:0000737)2.36637338
68Neonatal onset (HP:0003623)2.36524477
69Cardiovascular calcification (HP:0011915)2.30770988
70Amyloidosis (HP:0011034)2.29276710
71Malnutrition (HP:0004395)2.27772140
72Gingival bleeding (HP:0000225)2.27129749
73* Conjugated hyperbilirubinemia (HP:0002908)2.26370177
74Esophageal varix (HP:0002040)2.25274683
75Menorrhagia (HP:0000132)2.18125873
76Joint swelling (HP:0001386)2.17130919
77Sensorimotor neuropathy (HP:0007141)2.16027620
78Pancreatitis (HP:0001733)2.14315089
79Late onset (HP:0003584)2.12417724
80Thrombophlebitis (HP:0004418)2.11635099
81Epistaxis (HP:0000421)2.11542134
82Enlarged kidneys (HP:0000105)2.11275004
83Brushfield spots (HP:0001088)2.11201355
84Poikilocytosis (HP:0004447)2.10439318
85Hyperinsulinemic hypoglycemia (HP:0000825)2.09513746
86* Abnormal gallbladder morphology (HP:0012437)2.08141358
87Vomiting (HP:0002013)2.03993409
88Opisthotonus (HP:0002179)2.03785015
89Hemorrhage of the eye (HP:0011885)2.02406281
90Abnormal biliary tract physiology (HP:0012439)2.00706969
91Bile duct proliferation (HP:0001408)2.00706969
92Generalized aminoaciduria (HP:0002909)1.99825481
93Rickets (HP:0002748)1.95512392
94* Cholelithiasis (HP:0001081)1.94833548
95Increased serum ferritin (HP:0003281)1.91648767
96Abnormality of iron homeostasis (HP:0011031)1.91463523
97Abnormality of transition element cation homeostasis (HP:0011030)1.89817787
98Increased mean platelet volume (HP:0011877)1.88544963
99Abnormal cartilage morphology (HP:0002763)1.88330292
100Renal cortical cysts (HP:0000803)1.88048704
101Hypophosphatemic rickets (HP:0004912)1.86429863
102Arthropathy (HP:0003040)1.84214165
103Elevated hepatic transaminases (HP:0002910)1.83206540
104Hydroxyprolinuria (HP:0003080)1.82035208
105Abnormality of proline metabolism (HP:0010907)1.82035208
106Alkalosis (HP:0001948)1.81499977
107Reduced antithrombin III activity (HP:0001976)1.80019066
108Abnormal delivery (HP:0001787)1.80014615
109Status epilepticus (HP:0002133)1.78752731
110Nephritis (HP:0000123)1.78474264
111Abnormality of vitamin metabolism (HP:0100508)1.77372642
112Hyperglycemia (HP:0003074)1.76449357
113Generalized hypopigmentation of hair (HP:0011358)1.76340273
114Hyperphosphaturia (HP:0003109)1.75978655
115* Abnormality of the gallbladder (HP:0005264)1.72667769
116Acute hepatic failure (HP:0006554)1.71078210
117Abnormality of alanine metabolism (HP:0010916)1.70551542
118Hyperalaninemia (HP:0003348)1.70551542
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70551542
120Abnormal platelet volume (HP:0011876)1.69378734
121Glycosuria (HP:0003076)1.65830741
122Abnormality of urine glucose concentration (HP:0011016)1.65830741
123Gangrene (HP:0100758)1.62734558
124Abnormality of the Achilles tendon (HP:0005109)1.62421225
125Cerebral palsy (HP:0100021)1.58728346
126* Elevated alkaline phosphatase (HP:0003155)1.57680886
127Blue irides (HP:0000635)1.57618798
128Increased serum pyruvate (HP:0003542)1.53737940
129Bifid scrotum (HP:0000048)1.52038494
130Hematuria (HP:0000790)1.49279813
131Spontaneous hematomas (HP:0007420)1.49091254
132Anorexia (HP:0002039)1.47594275

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.92054169
2FGFR44.62724758
3SIK14.60200015
4ERN14.24600827
5TAOK33.27045061
6INSRR3.22723418
7ERBB43.03666965
8MAP2K42.32875164
9PKN22.19065273
10MST1R2.14479236
11PIK3CG2.02281590
12FLT31.92067169
13MAPK111.91942670
14LATS11.74975642
15TYK21.73950830
16TRIB31.67085527
17NLK1.63620425
18DAPK21.59643827
19FRK1.53155153
20FGFR21.50457276
21PTK61.48974169
22AKT31.48627637
23OBSCN1.47590648
24FER1.45526936
25ABL21.45166596
26NEK91.42790487
27NTRK31.41389267
28KDR1.26003782
29MAP3K71.25439968
30JAK21.25433509
31PRKAA21.16272728
32CAMKK21.15437422
33PINK11.11780445
34TNK21.11487389
35ERBB21.08430599
36PDGFRA1.07094866
37JAK11.06990382
38MAP3K101.06167561
39PRKG11.05070876
40TBK11.01793347
41MAP3K141.00533290
42MAP2K30.98382491
43GRK60.96987504
44MAPK40.96476131
45PRKCZ0.91824366
46MAPK150.90915311
47MAP3K20.88526512
48STK380.86758820
49MET0.86419763
50ARAF0.85657031
51STK38L0.84648801
52EPHB10.82337240
53CAMK1D0.81283574
54PRKACA0.81214758
55CDK60.80222154
56PDK20.77850556
57EPHA30.77454362
58MAPK120.77039416
59PRKACG0.75739125
60MAP3K30.75150180
61ACVR1B0.73487473
62TIE10.73154248
63LMTK20.73004707
64CAMK2G0.70204742
65DYRK1B0.69660435
66PRKAA10.69043081
67CSK0.68425713
68GSK3A0.67824375
69IRAK30.67074297
70WNK30.66185624
71SGK30.65456459
72BRSK20.64817543
73PRPF4B0.64812011
74MAP3K110.64015745
75FGFR30.63473139
76RIPK10.60721884
77MAP2K60.60383470
78CSF1R0.59486589
79PRKCB0.59146811
80MAPK70.58969285
81PRKACB0.57714024
82RPS6KA30.56952769
83PDGFRB0.55524586
84CSNK1G10.54528658
85PTK20.54112767
86CSNK1E0.54000276
87SGK10.53736501
88TGFBR20.53552425
89IKBKE0.52708139
90PRKCQ0.52681245
91PIM20.50988645
92SGK20.50899797
93PDPK10.50587019
94JAK30.50343282
95SRC0.47496393
96GRK10.46138704
97IGF1R0.45745641
98CSNK1D0.45046662
99PKN10.44747276
100ZAP700.44597594
101MAP3K130.44150849
102RET0.43653762
103EPHA40.42359566
104CDK90.42348739
105MAP3K50.41693450
106PRKCE0.41252530
107PRKCG0.39926526
108ICK0.39308669
109BLK0.38886198
110MAP2K10.38769021
111CDK40.38263997
112TEC0.37109128
113MTOR0.37005622
114RPS6KB10.36472698
115BCR0.36386479
116TAOK20.36029719
117SGK4940.35390392
118SGK2230.35390392
119MAPK100.34324389
120EGFR0.34215632
121PBK0.33765021
122MAP3K60.33611265
123CAMK1G0.33497742
124MAPK30.33381781
125CSNK1G20.32425755
126PDK10.32254524
127CAMK40.30356072
128MAP3K10.28710933
129CSNK1G30.28564571
130IRAK10.27822089
131IRAK20.26565359
132LATS20.25788733
133PAK30.25787220
134PRKCA0.25490018
135ABL10.22553385
136PIK3CA0.22365359
137CSNK1A1L0.21092294
138PDK30.19024834

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.56854329
2Nitrogen metabolism_Homo sapiens_hsa009103.77371430
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.38187878
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.36696545
5Arginine biosynthesis_Homo sapiens_hsa002203.06624601
6Complement and coagulation cascades_Homo sapiens_hsa046102.81105866
7Tryptophan metabolism_Homo sapiens_hsa003802.70196092
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.68262717
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.62509155
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53877607
11Fatty acid degradation_Homo sapiens_hsa000712.47882949
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37511874
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24593208
14Butanoate metabolism_Homo sapiens_hsa006502.14502105
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.13614134
16Peroxisome_Homo sapiens_hsa041462.06518841
17Chemical carcinogenesis_Homo sapiens_hsa052041.94037009
18Propanoate metabolism_Homo sapiens_hsa006401.93515461
19Steroid hormone biosynthesis_Homo sapiens_hsa001401.92437971
20Histidine metabolism_Homo sapiens_hsa003401.92390410
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.91604110
22PPAR signaling pathway_Homo sapiens_hsa033201.84153132
23Fatty acid metabolism_Homo sapiens_hsa012121.80237391
24Staphylococcus aureus infection_Homo sapiens_hsa051501.79176251
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76582258
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75804609
27Caffeine metabolism_Homo sapiens_hsa002321.73305346
28beta-Alanine metabolism_Homo sapiens_hsa004101.71276286
29Retinol metabolism_Homo sapiens_hsa008301.71057041
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65936083
31Selenocompound metabolism_Homo sapiens_hsa004501.59754400
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56853475
33Phenylalanine metabolism_Homo sapiens_hsa003601.55442909
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48379992
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.47928777
36Tyrosine metabolism_Homo sapiens_hsa003501.44748323
37* Bile secretion_Homo sapiens_hsa049761.39853621
38Pyruvate metabolism_Homo sapiens_hsa006201.35270776
39Sulfur metabolism_Homo sapiens_hsa009201.34794902
40Fatty acid elongation_Homo sapiens_hsa000621.33311380
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.29362650
42Starch and sucrose metabolism_Homo sapiens_hsa005001.28048536
43Steroid biosynthesis_Homo sapiens_hsa001001.24275939
44Biosynthesis of amino acids_Homo sapiens_hsa012301.18443218
45Folate biosynthesis_Homo sapiens_hsa007901.18077187
46Fat digestion and absorption_Homo sapiens_hsa049751.16201113
47Carbon metabolism_Homo sapiens_hsa012001.11904427
48* ABC transporters_Homo sapiens_hsa020101.08167578
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03960175
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.03289477
51Vitamin B6 metabolism_Homo sapiens_hsa007500.99075273
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.96267506
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95956161
54Arginine and proline metabolism_Homo sapiens_hsa003300.94123816
55Sulfur relay system_Homo sapiens_hsa041220.89887809
56Vitamin digestion and absorption_Homo sapiens_hsa049770.85889519
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85209938
58Lysine degradation_Homo sapiens_hsa003100.82219125
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81733393
60One carbon pool by folate_Homo sapiens_hsa006700.77919345
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69217624
62Glycerolipid metabolism_Homo sapiens_hsa005610.66955753
63Glutathione metabolism_Homo sapiens_hsa004800.63911841
64Fatty acid biosynthesis_Homo sapiens_hsa000610.57801292
65Pentose phosphate pathway_Homo sapiens_hsa000300.55610332
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45836555
67Metabolic pathways_Homo sapiens_hsa011000.45163321
68Pertussis_Homo sapiens_hsa051330.40452477
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39051776
70Prion diseases_Homo sapiens_hsa050200.38844288
71Galactose metabolism_Homo sapiens_hsa000520.24884512
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24632313
73Insulin resistance_Homo sapiens_hsa049310.23427803
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.22290295
75Linoleic acid metabolism_Homo sapiens_hsa005910.20384206
76Fructose and mannose metabolism_Homo sapiens_hsa000510.20220835
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20113274
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.15485932
79Serotonergic synapse_Homo sapiens_hsa047260.10794120
80Glucagon signaling pathway_Homo sapiens_hsa049220.10072017
81AMPK signaling pathway_Homo sapiens_hsa041520.01339486
82FoxO signaling pathway_Homo sapiens_hsa04068-0.2654480
83Bladder cancer_Homo sapiens_hsa05219-0.2455396
84Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2358598
85Amoebiasis_Homo sapiens_hsa05146-0.2305833
86Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2288993
87Platelet activation_Homo sapiens_hsa04611-0.2253416
88Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2242055
89Sphingolipid metabolism_Homo sapiens_hsa00600-0.2179070
90Type II diabetes mellitus_Homo sapiens_hsa04930-0.2146804
91Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2097965
92Circadian rhythm_Homo sapiens_hsa04710-0.2022344
93Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1950775
94Renin-angiotensin system_Homo sapiens_hsa04614-0.1946979
95Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.1873101
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1805394
97Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1781228
98Hepatitis C_Homo sapiens_hsa05160-0.1746624
99Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1606771
100Mineral absorption_Homo sapiens_hsa04978-0.1590344
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1520033
102African trypanosomiasis_Homo sapiens_hsa05143-0.1501713
103Regulation of autophagy_Homo sapiens_hsa04140-0.1368468
104Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1240082
105Other glycan degradation_Homo sapiens_hsa00511-0.1121514
106Insulin signaling pathway_Homo sapiens_hsa04910-0.0952069
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0878932
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0766868
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0624906
110Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0624752

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