ABCB6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. This protein is a member of the heavy metal importer subfamily and plays a role in porphyrin transport. This gene is the molecular basis of the Langereis (Lan) blood group antigen and mutations in this gene underlie familial pseudohyperkalemia and dyschromatosis universalis hereditaria. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.98242574
2L-phenylalanine catabolic process (GO:0006559)6.98242574
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77489318
4L-phenylalanine metabolic process (GO:0006558)6.77489318
5aromatic amino acid family catabolic process (GO:0009074)6.29153824
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.90678774
7cysteine metabolic process (GO:0006534)5.74755498
8kynurenine metabolic process (GO:0070189)5.72784024
9glyoxylate metabolic process (GO:0046487)5.68431938
10tryptophan catabolic process (GO:0006569)5.65859121
11indole-containing compound catabolic process (GO:0042436)5.65859121
12indolalkylamine catabolic process (GO:0046218)5.65859121
13bile acid biosynthetic process (GO:0006699)5.51179387
14alpha-linolenic acid metabolic process (GO:0036109)5.49516158
15sulfur amino acid catabolic process (GO:0000098)5.47722180
16urea cycle (GO:0000050)5.34597082
17urea metabolic process (GO:0019627)5.34597082
18tryptophan metabolic process (GO:0006568)5.31161790
19serine family amino acid catabolic process (GO:0009071)5.24400292
20lysine metabolic process (GO:0006553)5.22873755
21lysine catabolic process (GO:0006554)5.22873755
22negative regulation of fibrinolysis (GO:0051918)5.14383206
23high-density lipoprotein particle remodeling (GO:0034375)5.05169433
24glycine metabolic process (GO:0006544)4.92725578
25nitrogen cycle metabolic process (GO:0071941)4.92415206
26regulation of protein activation cascade (GO:2000257)4.91970551
27complement activation, alternative pathway (GO:0006957)4.84286060
28regulation of fibrinolysis (GO:0051917)4.83020406
29homocysteine metabolic process (GO:0050667)4.82998179
30peptidyl-glutamic acid carboxylation (GO:0017187)4.80962111
31protein carboxylation (GO:0018214)4.80962111
32amino-acid betaine metabolic process (GO:0006577)4.77223379
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74255035
34bile acid metabolic process (GO:0008206)4.73965222
35aromatic amino acid family metabolic process (GO:0009072)4.66636349
36regulation of triglyceride catabolic process (GO:0010896)4.64645194
37regulation of complement activation (GO:0030449)4.61288172
38serine family amino acid metabolic process (GO:0009069)4.60411084
39alpha-amino acid catabolic process (GO:1901606)4.58432291
40serine family amino acid biosynthetic process (GO:0009070)4.49702563
41cellular ketone body metabolic process (GO:0046950)4.46124040
42reverse cholesterol transport (GO:0043691)4.39068399
43negative regulation of cholesterol transport (GO:0032375)4.38430000
44negative regulation of sterol transport (GO:0032372)4.38430000
45tyrosine metabolic process (GO:0006570)4.36211162
46protein-lipid complex remodeling (GO:0034368)4.32610410
47macromolecular complex remodeling (GO:0034367)4.32610410
48plasma lipoprotein particle remodeling (GO:0034369)4.32610410
49regulation of cholesterol esterification (GO:0010872)4.28208356
50coenzyme catabolic process (GO:0009109)4.27956670
51cellular amino acid catabolic process (GO:0009063)4.27836148
52triglyceride homeostasis (GO:0070328)4.26211253
53acylglycerol homeostasis (GO:0055090)4.26211253
54glutamate metabolic process (GO:0006536)4.21761705
55ethanol oxidation (GO:0006069)4.20908879
56plasma lipoprotein particle clearance (GO:0034381)4.16738224
57bile acid and bile salt transport (GO:0015721)4.16654678
58phospholipid efflux (GO:0033700)4.04056749
59cellular modified amino acid catabolic process (GO:0042219)4.01135533
60proline biosynthetic process (GO:0006561)4.00069740
61acetyl-CoA metabolic process (GO:0006084)3.97312256
62indolalkylamine metabolic process (GO:0006586)3.95041869
63plasma lipoprotein particle assembly (GO:0034377)3.92317846
64aspartate family amino acid catabolic process (GO:0009068)3.91385852
65glucose 6-phosphate metabolic process (GO:0051156)3.90663417
66imidazole-containing compound metabolic process (GO:0052803)3.90575210
67benzene-containing compound metabolic process (GO:0042537)3.88344445
68ketone body metabolic process (GO:1902224)3.88318158
69dicarboxylic acid biosynthetic process (GO:0043650)3.87446896
70drug catabolic process (GO:0042737)3.87208974
71cellular glucuronidation (GO:0052695)3.83686675
72cellular biogenic amine catabolic process (GO:0042402)3.83335835
73amine catabolic process (GO:0009310)3.83335835
74arginine metabolic process (GO:0006525)3.79836395
75very-low-density lipoprotein particle assembly (GO:0034379)3.79033397
76short-chain fatty acid metabolic process (GO:0046459)3.78975739
77cholesterol efflux (GO:0033344)3.78112750
78organic acid catabolic process (GO:0016054)3.77501748
79carboxylic acid catabolic process (GO:0046395)3.77501748
80cofactor catabolic process (GO:0051187)3.76980002
812-oxoglutarate metabolic process (GO:0006103)3.75871176
82aldehyde catabolic process (GO:0046185)3.73749316
834-hydroxyproline metabolic process (GO:0019471)3.67010289
84proline metabolic process (GO:0006560)3.64024941
85carnitine metabolic process (GO:0009437)3.62766334
86regulation of cholesterol homeostasis (GO:2000188)3.62512982
87positive regulation of triglyceride lipase activity (GO:0061365)3.62292089
88positive regulation of lipoprotein lipase activity (GO:0051006)3.62292089
89protoporphyrinogen IX metabolic process (GO:0046501)3.61240422
90cholesterol homeostasis (GO:0042632)3.58279553
91fibrinolysis (GO:0042730)3.57366656
92blood coagulation, intrinsic pathway (GO:0007597)3.56551142
93positive regulation of lipid catabolic process (GO:0050996)3.55296817
94fatty acid oxidation (GO:0019395)3.54010349
95regulation of cholesterol biosynthetic process (GO:0045540)3.53810455
96L-serine metabolic process (GO:0006563)3.53431332
97fatty acid beta-oxidation (GO:0006635)3.52839376
98protein-lipid complex assembly (GO:0065005)3.52232269
99sterol homeostasis (GO:0055092)3.52197781
100phospholipid homeostasis (GO:0055091)3.51237969
101Golgi transport vesicle coating (GO:0048200)3.49499958
102COPI coating of Golgi vesicle (GO:0048205)3.49499958
103monocarboxylic acid catabolic process (GO:0072329)3.49343577
104lipid oxidation (GO:0034440)3.46348027
105protoporphyrinogen IX biosynthetic process (GO:0006782)3.46274172
106drug transmembrane transport (GO:0006855)3.44054692
107negative regulation of fatty acid biosynthetic process (GO:0045717)3.44027303
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.39664680
109protein retention in ER lumen (GO:0006621)3.25711140
110glycolytic process (GO:0006096)3.08350710
111gluconeogenesis (GO:0006094)2.93880738
112cholesterol biosynthetic process (GO:0006695)2.92710811
113retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.91116993
114intestinal cholesterol absorption (GO:0030299)2.90870274
115daunorubicin metabolic process (GO:0044597)2.90173736
116polyketide metabolic process (GO:0030638)2.90173736
117doxorubicin metabolic process (GO:0044598)2.90173736
118* porphyrin-containing compound biosynthetic process (GO:0006779)2.82944365
119hexose biosynthetic process (GO:0019319)2.81944595
120monosaccharide biosynthetic process (GO:0046364)2.78463367
121* porphyrin-containing compound metabolic process (GO:0006778)2.77061348
122peptidyl-proline hydroxylation (GO:0019511)2.75811662
123regulation of translational fidelity (GO:0006450)2.75279352
124glutamine family amino acid biosynthetic process (GO:0009084)2.56117661
125plasma lipoprotein particle organization (GO:0071827)2.51422100
126pyruvate metabolic process (GO:0006090)2.49414028
127lung epithelium development (GO:0060428)2.49338489
128aminoglycoside antibiotic metabolic process (GO:0030647)2.48578418
129cell migration in hindbrain (GO:0021535)2.46860433
130* tetrapyrrole biosynthetic process (GO:0033014)2.46750550
131positive regulation of mitochondrial fission (GO:0090141)2.46569404
132protein hydroxylation (GO:0018126)2.45944096
133sterol biosynthetic process (GO:0016126)2.45608747
134regulation of plasminogen activation (GO:0010755)2.45540236
135regulation of cholesterol metabolic process (GO:0090181)2.44543745
136mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.41459565
137heme biosynthetic process (GO:0006783)2.41129794
138biotin metabolic process (GO:0006768)2.40081090
139protein-lipid complex subunit organization (GO:0071825)2.37784069
140positive regulation of synapse maturation (GO:0090129)2.32601722
141heme metabolic process (GO:0042168)2.32501821
142L-serine transport (GO:0015825)2.31895025
143low-density lipoprotein particle remodeling (GO:0034374)2.30149608
144layer formation in cerebral cortex (GO:0021819)2.29850622
145cerebellar Purkinje cell layer development (GO:0021680)2.28401208
146long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.27912006
147COPII vesicle coating (GO:0048208)2.27578089
148hemoglobin metabolic process (GO:0020027)2.26779609
149basement membrane organization (GO:0071711)2.23371250
150activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.22926349
151erythrocyte maturation (GO:0043249)2.17457423
152positive regulation of nuclease activity (GO:0032075)2.16888895
153positive regulation of dendritic spine morphogenesis (GO:0061003)2.15444831
154glutamine family amino acid catabolic process (GO:0009065)2.14671173
155cytoskeletal anchoring at plasma membrane (GO:0007016)2.13476600
156oxygen transport (GO:0015671)2.11928695
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.10816710
158vesicle coating (GO:0006901)2.09681469

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.54142575
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.69746860
3EGR1_23403033_ChIP-Seq_LIVER_Mouse5.95560475
4LXR_22158963_ChIP-Seq_LIVER_Mouse5.74046445
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.46389764
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.77759944
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.60554162
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.77828354
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.45777995
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.13991693
11HIF1A_21447827_ChIP-Seq_MCF-7_Human2.63180193
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.35139578
13NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34732012
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.23159455
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.14312238
16E2F7_22180533_ChIP-Seq_HELA_Human2.08721510
17TP63_17297297_ChIP-ChIP_HaCaT_Human2.03758858
18GATA1_22025678_ChIP-Seq_K562_Human2.02782013
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00669842
20* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0628242
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.97350850
22CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.94838776
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.92722913
24* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.83032831
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.81409981
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.76112701
27ZNF263_19887448_ChIP-Seq_K562_Human1.71907960
28CLOCK_20551151_ChIP-Seq_293T_Human1.67215232
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.66914536
30* XRN2_22483619_ChIP-Seq_HELA_Human1.61388267
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.60908585
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57895257
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.57564644
34* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.52441940
35ZFP281_18757296_ChIP-ChIP_E14_Mouse1.49292357
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.47304850
37CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.46361105
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44789412
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.44681618
40* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39874520
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34922666
42* HNF4A_19822575_ChIP-Seq_HepG2_Human1.33516502
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.32658789
44NANOG_21062744_ChIP-ChIP_HESCs_Human1.32627660
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31687912
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29906236
47STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28317910
48KDM2B_26808549_Chip-Seq_K562_Human1.26790961
49CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25030005
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24456744
51SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24292947
52GABP_19822575_ChIP-Seq_HepG2_Human1.23223337
53RXRA_24833708_ChIP-Seq_LIVER_Mouse1.22577262
54SMC4_20622854_ChIP-Seq_HELA_Human1.19850345
55EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.19483249
56NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18744027
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.17805334
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15770694
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.13735726
60ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13614995
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13492617
62DCP1A_22483619_ChIP-Seq_HELA_Human1.12456266
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.10315914
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10027264
65SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08635047
66TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08275669
67* TP53_22127205_ChIP-Seq_IMR90_Human1.07558154
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07256433
69HTT_18923047_ChIP-ChIP_STHdh_Human1.06886466
70RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05666867
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.05395909
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.05013308
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04663604
74AR_21909140_ChIP-Seq_LNCAP_Human1.03602661
75POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02969711
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.02092819
77SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01667416
78HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01238896
79* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00734771
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.00502525
81TET1_21490601_ChIP-Seq_MESCs_Mouse0.99954379
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99882315
83* RARA_24833708_ChIP-Seq_LIVER_Mouse0.98695604
84CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97911712
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97886743
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97362148
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96889906
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95535383
89* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95283171
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.94412812
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93036028
92GATA1_19941826_ChIP-Seq_K562_Human0.92220012
93* LXR_22292898_ChIP-Seq_THP-1_Human0.92147506
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.90933555
95* GATA4_25053715_ChIP-Seq_YYC3_Human0.84590021
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84154767
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.83364398
98RARB_24833708_ChIP-Seq_LIVER_Mouse0.80402610
99POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.78222041
100FOXM1_23109430_ChIP-Seq_U2OS_Human0.77713170
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77675657
102* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.74350705
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.72944872
104* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.72570437
105PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.71196244
106BCOR_27268052_Chip-Seq_Bcells_Human0.70887305
107AUTS2_25519132_ChIP-Seq_293T-REX_Human0.70320208
108CREB1_15753290_ChIP-ChIP_HEK293T_Human0.69856654
109GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.69434738
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.68489870
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68059016
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.67096389
113* MYC_18358816_ChIP-ChIP_MESCs_Mouse0.66719955
114* GATA6_25053715_ChIP-Seq_YYC3_Human0.66345726
115PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.65736798
116P68_20966046_ChIP-Seq_HELA_Human0.64963732
117* ATF3_27146783_Chip-Seq_COLON_Human0.64100664
118KAP1_22055183_ChIP-Seq_ESCs_Mouse0.64003267
119BCL6_27268052_Chip-Seq_Bcells_Human0.62161579
120RACK7_27058665_Chip-Seq_MCF-7_Human0.62006897
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.60477767
122* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.59441980
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.59002787
124SALL4_18804426_ChIP-ChIP_XEN_Mouse0.58692474
125ESR2_21235772_ChIP-Seq_MCF-7_Human0.57490038
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.57365622
127GATA2_19941826_ChIP-Seq_K562_Human0.57281998
128ERG_21242973_ChIP-ChIP_JURKAT_Human0.56007175
129BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.55793864
130OCT4_18692474_ChIP-Seq_MEFs_Mouse0.55368667
131CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.55317119
132CREB1_26743006_Chip-Seq_LNCaP_Human0.54808568
133TAF2_19829295_ChIP-Seq_ESCs_Human0.54675269
134KLF4_18555785_ChIP-Seq_MESCs_Mouse0.54673944
135CEBPB_22108803_ChIP-Seq_LS180_Human0.54526351
136PHF8_20622854_ChIP-Seq_HELA_Human0.53873679
137KDM5A_27292631_Chip-Seq_BREAST_Human0.53693270
138AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.53329090
139CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.53131188
140E2F1_20622854_ChIP-Seq_HELA_Human0.52740648
141CTCF_21964334_Chip-Seq_Bcells_Human0.52688157
142KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.52244502
143PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.52039874
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.51909570
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51816000
146MYC_18555785_ChIP-Seq_MESCs_Mouse0.51185145
147SOX2_18692474_ChIP-Seq_MEFs_Mouse0.51138995
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.50883955
149ZFX_18555785_ChIP-Seq_MESCs_Mouse0.49836410
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.49686210
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.49124556
152* MYC_19915707_ChIP-ChIP_AK7_Human0.48880022
153* P53_21459846_ChIP-Seq_SAOS-2_Human0.48832751
154SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.47667833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.03192716
2MP0005360_urolithiasis7.26615694
3MP0005085_abnormal_gallbladder_physiolo6.14758197
4MP0005365_abnormal_bile_salt5.87288544
5MP0008875_abnormal_xenobiotic_pharmacok4.79418753
6MP0003806_abnormal_nucleotide_metabolis4.45388028
7MP0010329_abnormal_lipoprotein_level3.50398641
8MP0003252_abnormal_bile_duct3.48285672
9MP0005083_abnormal_biliary_tract3.47126239
10MP0009840_abnormal_foam_cell3.42359469
11MP0003122_maternal_imprinting2.99863853
12MP0005332_abnormal_amino_acid2.82310116
13MP0003656_abnormal_erythrocyte_physiolo2.71633033
14MP0001666_abnormal_nutrient_absorption2.69932578
15MP0003195_calcinosis2.46493376
16MP0001529_abnormal_vocalization2.27742796
17MP0004859_abnormal_synaptic_plasticity2.18689562
18MP0000609_abnormal_liver_physiology2.17550002
19MP0004019_abnormal_vitamin_homeostasis2.10884331
20MP0003191_abnormal_cellular_cholesterol2.09633240
21MP0002118_abnormal_lipid_homeostasis2.06812806
22MP0004270_analgesia1.97172542
23MP0005319_abnormal_enzyme/_coenzyme1.92023964
24MP0008260_abnormal_autophagy1.89721867
25MP0000566_synostosis1.78606393
26MP0004272_abnormal_basement_membrane1.76488188
27MP0003136_yellow_coat_color1.76174555
28MP0008438_abnormal_cutaneous_collagen1.73969111
29MP0003868_abnormal_feces_composition1.72610215
30MP0004858_abnormal_nervous_system1.69539902
31MP0001764_abnormal_homeostasis1.69274614
32MP0003123_paternal_imprinting1.68437309
33MP0004233_abnormal_muscle_weight1.65991221
34MP0003879_abnormal_hair_cell1.64236400
35MP0003705_abnormal_hypodermis_morpholog1.54542960
36MP0002138_abnormal_hepatobiliary_system1.53731652
37MP0005584_abnormal_enzyme/coenzyme_acti1.53562057
38MP0009780_abnormal_chondrocyte_physiolo1.49972866
39MP0003186_abnormal_redox_activity1.46451579
40MP0009643_abnormal_urine_homeostasis1.40658177
41MP0005451_abnormal_body_composition1.40486618
42MP0006036_abnormal_mitochondrial_physio1.40472603
43MP0004147_increased_porphyrin_level1.40014786
44MP0003942_abnormal_urinary_system1.36006340
45MP0003878_abnormal_ear_physiology1.32360862
46MP0005377_hearing/vestibular/ear_phenot1.32360862
47MP0005171_absent_coat_pigmentation1.26255098
48MP0002089_abnormal_postnatal_growth/wei1.25266443
49MP0005499_abnormal_olfactory_system1.24705121
50MP0005394_taste/olfaction_phenotype1.24705121
51MP0000598_abnormal_liver_morphology1.23336681
52MP0003011_delayed_dark_adaptation1.23308510
53MP0005636_abnormal_mineral_homeostasis1.22423106
54MP0005670_abnormal_white_adipose1.17819859
55MP0003385_abnormal_body_wall1.12352755
56MP0005257_abnormal_intraocular_pressure1.12052931
57MP0000751_myopathy1.11161574
58MP0010030_abnormal_orbit_morphology1.09892931
59MP0008932_abnormal_embryonic_tissue1.07555474
60MP0003111_abnormal_nucleus_morphology1.07362180
61MP0000955_abnormal_spinal_cord1.06676667
62MP0009697_abnormal_copulation1.06608607
63MP0001984_abnormal_olfaction1.03356872
64MP0004130_abnormal_muscle_cell0.99248320
65MP0002909_abnormal_adrenal_gland0.97527342
66MP0001661_extended_life_span0.97090829
67MP0000604_amyloidosis0.96896185
68MP0005647_abnormal_sex_gland0.96482899
69MP0003890_abnormal_embryonic-extraembry0.95949904
70MP0006035_abnormal_mitochondrial_morpho0.95866382
71MP0001299_abnormal_eye_distance/0.95553865
72MP0002837_dystrophic_cardiac_calcinosis0.95518981
73MP0003941_abnormal_skin_development0.95350385
74MP0004133_heterotaxia0.94685684
75MP0002697_abnormal_eye_size0.94333329
76MP0006276_abnormal_autonomic_nervous0.93060088
77MP0000749_muscle_degeneration0.91703371
78MP0005423_abnormal_somatic_nervous0.91519917
79MP0000003_abnormal_adipose_tissue0.87123135
80MP0001756_abnormal_urination0.86830930
81MP0005076_abnormal_cell_differentiation0.86141688
82MP0001915_intracranial_hemorrhage0.85148254
83MP0002249_abnormal_larynx_morphology0.84763432
84MP0009763_increased_sensitivity_to0.84073289
85MP0009642_abnormal_blood_homeostasis0.83978868
86MP0003567_abnormal_fetal_cardiomyocyte0.83814522
87MP0003566_abnormal_cell_adhesion0.83643673
88MP0009053_abnormal_anal_canal0.83432127
89MP0003861_abnormal_nervous_system0.81396877
90MP0004087_abnormal_muscle_fiber0.81127122
91MP0002078_abnormal_glucose_homeostasis0.81036030
92MP0005266_abnormal_metabolism0.80879494
93MP0004145_abnormal_muscle_electrophysio0.80367058
94MP0005376_homeostasis/metabolism_phenot0.80246050
95MP0002971_abnormal_brown_adipose0.79895972
96MP0002152_abnormal_brain_morphology0.79325152
97MP0004811_abnormal_neuron_physiology0.78969934
98MP0002638_abnormal_pupillary_reflex0.78508715
99MP0002822_catalepsy0.77726049
100MP0003115_abnormal_respiratory_system0.77056776
101MP0003121_genomic_imprinting0.74404467
102MP0002092_abnormal_eye_morphology0.74286789
103MP0008789_abnormal_olfactory_epithelium0.74219130
104MP0003329_amyloid_beta_deposits0.73993241
105MP0003635_abnormal_synaptic_transmissio0.73744692
106MP0000778_abnormal_nervous_system0.73687865
107MP0003718_maternal_effect0.73372646
108MP0002734_abnormal_mechanical_nocicepti0.73361914
109MP0002080_prenatal_lethality0.72707488
110MP0002269_muscular_atrophy0.72671825
111MP0005220_abnormal_exocrine_pancreas0.72071025
112MP0000049_abnormal_middle_ear0.71636248
113MP0009764_decreased_sensitivity_to0.71211617
114MP0008469_abnormal_protein_level0.70617715
115MP0002882_abnormal_neuron_morphology0.70111193
116MP0000534_abnormal_ureter_morphology0.70055003
117MP0002233_abnormal_nose_morphology0.69898667
118MP0001270_distended_abdomen0.69847691
119MP0001697_abnormal_embryo_size0.68885165
120MP0005408_hypopigmentation0.68687204
121MP0003315_abnormal_perineum_morphology0.68170262
122MP0005334_abnormal_fat_pad0.67355483
123MP0005666_abnormal_adipose_tissue0.67310157
124MP0009765_abnormal_xenobiotic_induced0.67306997
125MP0001672_abnormal_embryogenesis/_devel0.65022226
126MP0005380_embryogenesis_phenotype0.65022226
127MP0002653_abnormal_ependyma_morphology0.64981553
128MP0005535_abnormal_body_temperature0.64360663
129MP0009672_abnormal_birth_weight0.55693213
130MP0008872_abnormal_physiological_respon0.54437015
131MP0002876_abnormal_thyroid_physiology0.53275554
132MP0005448_abnormal_energy_balance0.52744858
133MP0005084_abnormal_gallbladder_morpholo0.52077363
134MP0002136_abnormal_kidney_physiology0.51670363
135MP0002970_abnormal_white_adipose0.49945590
136MP0003646_muscle_fatigue0.48243082
137MP0008873_increased_physiological_sensi0.48000319
138MP0005330_cardiomyopathy0.47928244
139MP0005395_other_phenotype0.46209360
140MP0010368_abnormal_lymphatic_system0.43915919
141MP0003953_abnormal_hormone_level0.43582612
142MP0003221_abnormal_cardiomyocyte_apopto0.42261877
143MP0005187_abnormal_penis_morphology0.42241521
144MP0004264_abnormal_extraembryonic_tissu0.41413480
145MP0000747_muscle_weakness0.40629133
146MP0005058_abnormal_lysosome_morphology0.40470137
147MP0004043_abnormal_pH_regulation0.40373816
148MP0003690_abnormal_glial_cell0.39964839
149MP0004185_abnormal_adipocyte_glucose0.39485623
150MP0000639_abnormal_adrenal_gland0.35973459
151MP0009115_abnormal_fat_cell0.35972694
152MP0002254_reproductive_system_inflammat0.34967381
153MP0003638_abnormal_response/metabolism_0.33612732
154MP0001243_abnormal_dermal_layer0.33512635
155MP0002796_impaired_skin_barrier0.32855615
156MP0008874_decreased_physiological_sensi0.31589381
157MP0000358_abnormal_cell_content/0.30993892
158MP0005464_abnormal_platelet_physiology0.30570781
159MP0000230_abnormal_systemic_arterial0.28337613
160MP0002135_abnormal_kidney_morphology0.27550110
161MP0005375_adipose_tissue_phenotype0.26752300
162MP0003699_abnormal_female_reproductive0.26655498
163MP0005452_abnormal_adipose_tissue0.25694104
164MP0002132_abnormal_respiratory_system0.24312795
165MP0010234_abnormal_vibrissa_follicle0.22521267
166MP0002090_abnormal_vision0.21548475
167MP0001730_embryonic_growth_arrest0.20903657
168MP0005248_abnormal_Harderian_gland0.20794190

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.61028744
2Deep venous thrombosis (HP:0002625)6.58147276
3Intrahepatic cholestasis (HP:0001406)6.43661762
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.13377896
5Hypobetalipoproteinemia (HP:0003563)5.98995951
6Xanthomatosis (HP:0000991)5.90145986
7Prolonged partial thromboplastin time (HP:0003645)5.31216734
8Hyperlipoproteinemia (HP:0010980)5.09782226
9Hyperammonemia (HP:0001987)4.65683520
10Hypolipoproteinemia (HP:0010981)4.61642827
11Complement deficiency (HP:0004431)4.58122952
12Hyperglycinemia (HP:0002154)4.56556623
13Ketosis (HP:0001946)4.40951114
14Hyperglycinuria (HP:0003108)4.33118841
15Abnormality of sulfur amino acid metabolism (HP:0004339)4.24451081
16Abnormality of glycine metabolism (HP:0010895)4.22157872
17Abnormality of serine family amino acid metabolism (HP:0010894)4.22157872
18Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.14459311
19Hypoalphalipoproteinemia (HP:0003233)4.09800732
20Abnormality of methionine metabolism (HP:0010901)3.96921915
21Epidermoid cyst (HP:0200040)3.94283459
22Hypoglycemic coma (HP:0001325)3.92417507
23Abnormality of aspartate family amino acid metabolism (HP:0010899)3.92360775
24Abnormality of pyrimidine metabolism (HP:0004353)3.91058215
25Abnormality of glutamine family amino acid metabolism (HP:0010902)3.87812163
26Joint hemorrhage (HP:0005261)3.78306404
27Hyperbilirubinemia (HP:0002904)3.72808640
28Abnormality of the common coagulation pathway (HP:0010990)3.70138867
29Abnormality of fatty-acid metabolism (HP:0004359)3.67538792
30Fat malabsorption (HP:0002630)3.64465386
31Abnormality of reticulocytes (HP:0004312)3.62829010
32Abnormality of glycolysis (HP:0004366)3.60514277
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.48238320
34Poikilocytosis (HP:0004447)3.48165091
35Acanthocytosis (HP:0001927)3.37412914
36Hypochromic microcytic anemia (HP:0004840)3.36492210
37Abnormality of complement system (HP:0005339)3.34611533
38Ketoacidosis (HP:0001993)3.25800108
39Abnormality of the intrinsic pathway (HP:0010989)3.24629150
40Cholelithiasis (HP:0001081)3.24389677
41Abnormality of serum amino acid levels (HP:0003112)3.23217234
42Abnormal gallbladder morphology (HP:0012437)3.15510013
43Abnormality of nucleobase metabolism (HP:0010932)3.14639650
44Hypercholesterolemia (HP:0003124)3.13646365
45Hepatocellular carcinoma (HP:0001402)3.08116694
46Gout (HP:0001997)3.03459995
47Abnormality of dicarboxylic acid metabolism (HP:0010995)3.02561675
48Dicarboxylic aciduria (HP:0003215)3.02561675
49Metabolic acidosis (HP:0001942)2.97131847
50Increased serum pyruvate (HP:0003542)2.94035977
51Delayed CNS myelination (HP:0002188)2.93175878
52Cholecystitis (HP:0001082)2.92870897
53Abnormal gallbladder physiology (HP:0012438)2.92870897
54Reticulocytosis (HP:0001923)2.90934176
55Conjugated hyperbilirubinemia (HP:0002908)2.87650434
56Lethargy (HP:0001254)2.87273052
57Abnormality of purine metabolism (HP:0004352)2.76430368
58Exercise-induced muscle cramps (HP:0003710)2.74821024
59Abnormality of the heme biosynthetic pathway (HP:0010472)2.74191428
60Steatorrhea (HP:0002570)2.71270583
61Skin nodule (HP:0200036)2.70445208
62Cerebral edema (HP:0002181)2.66928845
63Spastic diplegia (HP:0001264)2.65241420
64Myocardial infarction (HP:0001658)2.49817332
65Abnormality of the gallbladder (HP:0005264)2.46320999
66Brushfield spots (HP:0001088)2.43522496
67Small epiphyses (HP:0010585)2.42596624
68Spontaneous abortion (HP:0005268)2.39485868
69Malnutrition (HP:0004395)2.35455213
70Irritability (HP:0000737)2.34229806
71Vomiting (HP:0002013)2.32536780
72Mitral stenosis (HP:0001718)2.31544582
73Neonatal onset (HP:0003623)2.26301841
74Insomnia (HP:0100785)2.23008488
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21795797
76Hypoglycemic seizures (HP:0002173)2.19526187
77Vascular calcification (HP:0004934)2.17131287
78Abnormality of the Achilles tendon (HP:0005109)2.17034121
79Generalized aminoaciduria (HP:0002909)2.16518589
80Systemic lupus erythematosus (HP:0002725)2.15785063
81Nausea (HP:0002018)2.15664973
82Hammertoe (HP:0001765)2.15288608
83Impaired pain sensation (HP:0007328)2.14319615
84Abnormality of pain sensation (HP:0010832)2.14319615
85Abnormal tarsal ossification (HP:0008369)2.13581611
86Abnormality of transition element cation homeostasis (HP:0011030)2.13283318
87Abnormality of iron homeostasis (HP:0011031)2.12283337
88Pterygium (HP:0001059)2.08838493
89Sensorimotor neuropathy (HP:0007141)2.07791138
90Polycythemia (HP:0001901)2.07186561
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.06710511
92Late onset (HP:0003584)2.06438397
93Abnormal cartilage morphology (HP:0002763)2.05248700
94Increased purine levels (HP:0004368)2.02148355
95Hyperuricemia (HP:0002149)2.02148355
96Hand muscle atrophy (HP:0009130)2.01036013
97Global brain atrophy (HP:0002283)1.98069150
98Hemorrhage of the eye (HP:0011885)1.97908142
99Broad alveolar ridges (HP:0000187)1.97755911
100Pancreatitis (HP:0001733)1.97740323
101Premature rupture of membranes (HP:0001788)1.97228564
102Diaphragmatic weakness (HP:0009113)1.94562094
103Distal upper limb amyotrophy (HP:0007149)1.91928346
104Upper limb amyotrophy (HP:0009129)1.91928346
105Cardiovascular calcification (HP:0011915)1.91346799
106Esophageal varix (HP:0002040)1.91217977
107Hyperinsulinemic hypoglycemia (HP:0000825)1.91152193
108Abnormality of carpal bone ossification (HP:0006257)1.90414540
109Proximal tubulopathy (HP:0000114)1.90231999
110Myoglobinuria (HP:0002913)1.87742995
111Opisthotonus (HP:0002179)1.86237632
112Glomerulonephritis (HP:0000099)1.85758581
113Hyperglycemia (HP:0003074)1.85313973
114Increased serum ferritin (HP:0003281)1.84978193
115Myopathic facies (HP:0002058)1.84660374
116Ulnar bowing (HP:0003031)1.83674316
117Rickets (HP:0002748)1.82678421
118Status epilepticus (HP:0002133)1.82416015
119Back pain (HP:0003418)1.80702339
120Enlarged kidneys (HP:0000105)1.80490513
121Abnormality of dentin (HP:0010299)1.80094198
122Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.79602709
123Absent epiphyses (HP:0010577)1.79602709
124Breech presentation (HP:0001623)1.79166033
125Hyperthyroidism (HP:0000836)1.78507626
126Ileus (HP:0002595)1.78476862
127Protrusio acetabuli (HP:0003179)1.78360775
128Thrombophlebitis (HP:0004418)1.77490662
129Abnormality of vitamin metabolism (HP:0100508)1.76438289
130Overlapping toe (HP:0001845)1.76203175
131Exercise-induced myalgia (HP:0003738)1.75548581
132Osteomalacia (HP:0002749)1.73805017
133Abnormal delivery (HP:0001787)1.71945746
134Achilles tendon contracture (HP:0001771)1.70319126
135Myokymia (HP:0002411)1.66716479
136Upper limb muscle weakness (HP:0003484)1.64063169
137Nuclear cataract (HP:0100018)1.61645490
138Termporal pattern (HP:0011008)1.60404504
139Insidious onset (HP:0003587)1.60404504
140Paralysis (HP:0003470)1.58883754
141Peripheral hypomyelination (HP:0007182)1.58056585
142Bronchomalacia (HP:0002780)1.54668518
143Broad palm (HP:0001169)1.52982502
144Atelectasis (HP:0100750)1.52584050
145Asymmetry of the thorax (HP:0001555)1.52404067
146Hypoparathyroidism (HP:0000829)1.52182284
147Shallow orbits (HP:0000586)1.51618311
148Alacrima (HP:0000522)1.50712550
149Decreased motor nerve conduction velocity (HP:0003431)1.50495086
150Coronal craniosynostosis (HP:0004440)1.49413517
151Menorrhagia (HP:0000132)1.49116130
152Cortical dysplasia (HP:0002539)1.49054194
153Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.48043123
154Myelomeningocele (HP:0002475)1.46096068
155Rhabdomyolysis (HP:0003201)1.44887480
156Foot dorsiflexor weakness (HP:0009027)1.43005891
157Hyperacusis (HP:0010780)1.42469670
158Abnormal ossification of hand bones (HP:0005921)1.41999565
159Abnormality of the calcaneus (HP:0008364)1.41339254
160Abnormal hemoglobin (HP:0011902)1.41247082
161Heterotopia (HP:0002282)1.40701407
162Truncus arteriosus (HP:0001660)1.40372680
163Hepatoblastoma (HP:0002884)1.40291929
164Abnormality of the aortic arch (HP:0012303)1.39688233
165Vertebral compression fractures (HP:0002953)1.38982112
166Neonatal death (HP:0003811)1.37819932
167Turricephaly (HP:0000262)1.34026875

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.10333693
2ERN13.62747296
3SIK13.61737840
4TRIB33.12978241
5FGFR42.96532123
6PKN22.74082765
7PDK42.50261870
8PDK32.50261870
9NEK12.46539867
10EIF2AK12.30923709
11ERBB42.27468321
12MST1R2.14221285
13PRKD32.09851790
14MAP2K41.85203783
15CDK121.82488132
16PBK1.77557017
17MAPK111.75676015
18TAOK31.72067950
19MARK11.71888385
20BUB11.70684228
21SIK21.69200740
22PIM21.58381570
23FLT31.55465466
24ABL21.46529897
25DAPK21.44005714
26SMG11.43646858
27MAP3K101.36889900
28NME11.36769881
29MAPKAPK31.35542156
30LATS11.31364446
31ICK1.28793331
32GRK61.21929104
33ARAF1.21251981
34PINK11.15264657
35NTRK21.14768806
36PDK21.14449439
37TYRO31.14139601
38WEE11.13809358
39PTK61.10905188
40BCR1.10415933
41MAP2K31.05720998
42PHKG21.05338877
43PHKG11.05338877
44NEK21.05295153
45KDR1.04540753
46CDK41.03310593
47INSRR1.02442280
48CAMK1G0.99373326
49ERBB20.98070284
50MAP3K110.97145453
51MET0.95341873
52EPHA20.95272173
53MAP3K90.94560564
54MAP2K20.94061528
55SCYL20.93656358
56CDK60.91670899
57PRKAA10.90488223
58CDK70.90443914
59PIK3CG0.89417993
60DYRK20.85969916
61JAK20.85699506
62EPHA30.85003325
63IRAK30.84348349
64CAMK1D0.83193055
65BRSK10.83069720
66TTK0.82123721
67MAP3K80.80709565
68NME20.80505354
69PAK60.80252214
70NEK90.79254111
71PRKAA20.79226644
72MAP2K10.78955507
73MTOR0.76220601
74STK380.75287722
75CDK150.74838540
76CDK140.73131326
77TSSK60.72653606
78EEF2K0.72443375
79MAPKAPK50.72361199
80AURKA0.71986147
81CDK11A0.71297872
82CDK180.71133044
83SRPK10.69717042
84RIPK10.69266887
85EPHB20.69186386
86DYRK1B0.68833140
87LATS20.67808633
88TYK20.65874810
89PRKCZ0.65403992
90PRKACG0.64910853
91PLK20.64892912
92CDC70.64571186
93MAPK120.64203645
94TESK20.63822389
95KSR20.63053398
96TTN0.62519066
97TAOK10.61792927
98CAMK2B0.60898361
99MAP3K30.60476925
100MARK20.59897658
101CSNK1G20.58132898
102BRSK20.57575019
103PTK20.57109844
104LMTK20.55501180
105PRKCI0.53922507
106RPS6KB20.53741149
107MAP2K70.53548530
108ACVR1B0.53397927
109MAP3K50.53220858
110STK40.52696233
111NTRK30.52500528
112GSK3A0.51288141
113FGFR10.50879193
114EIF2AK30.50431049
115MAP3K70.50352136
116BRAF0.50053317
117EPHA40.48695779
118AKT20.48532109
119MINK10.48089507
120CSNK1G30.47717267
121PDPK10.47698875
122MAPK40.46694187
123DYRK30.45662449
124UHMK10.45468314
125CDK10.45406499
126MAP2K60.44267517
127PDGFRA0.43961564
128FGFR30.43863753
129WNK10.43739421
130SGK2230.42904966
131SGK4940.42904966
132FER0.42699587
133OBSCN0.41439933
134WNK30.41082881
135TLK10.40632576
136MAP3K60.40480995
137CDK50.40157919
138WNK40.39975735
139MAPK100.39894006
140PLK10.36722372
141STK38L0.36033299
142CAMK2G0.35113539
143RET0.34961915
144STK30.32257065
145PDK10.29002010
146AURKB0.27937630
147RPS6KA10.27569242
148SGK30.27285506
149BMX0.25824044
150CSNK1E0.25735869
151NTRK10.25437589
152STK160.25425479
153PRKCG0.25189019
154PIK3CA0.22536397
155CAMKK10.22141669

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.03128287
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.34302013
3Nitrogen metabolism_Homo sapiens_hsa009103.24078818
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.14292285
5Arginine biosynthesis_Homo sapiens_hsa002202.88979595
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.87024222
7Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67288939
8Fatty acid degradation_Homo sapiens_hsa000712.59364646
9Tryptophan metabolism_Homo sapiens_hsa003802.56914345
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.49398990
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.47149830
12Complement and coagulation cascades_Homo sapiens_hsa046102.29787888
13Propanoate metabolism_Homo sapiens_hsa006402.20629922
14Butanoate metabolism_Homo sapiens_hsa006502.18439479
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.06397198
16Pentose and glucuronate interconversions_Homo sapiens_hsa000402.05965042
17Peroxisome_Homo sapiens_hsa041461.95153465
18Fatty acid metabolism_Homo sapiens_hsa012121.90128599
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.89232567
20PPAR signaling pathway_Homo sapiens_hsa033201.85269955
21Selenocompound metabolism_Homo sapiens_hsa004501.75243861
22beta-Alanine metabolism_Homo sapiens_hsa004101.75109729
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.74466071
24Chemical carcinogenesis_Homo sapiens_hsa052041.72931874
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.71799091
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.70741222
27Histidine metabolism_Homo sapiens_hsa003401.69021125
28Pyruvate metabolism_Homo sapiens_hsa006201.68347634
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65056625
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56996970
31Steroid hormone biosynthesis_Homo sapiens_hsa001401.56726052
32Vitamin B6 metabolism_Homo sapiens_hsa007501.54419123
33Biosynthesis of amino acids_Homo sapiens_hsa012301.53934162
34Carbon metabolism_Homo sapiens_hsa012001.53721983
35Caffeine metabolism_Homo sapiens_hsa002321.53656965
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.51848989
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50920989
38Phenylalanine metabolism_Homo sapiens_hsa003601.50915614
39Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.48670930
40Retinol metabolism_Homo sapiens_hsa008301.47128595
41Bile secretion_Homo sapiens_hsa049761.44731771
42Sulfur metabolism_Homo sapiens_hsa009201.39938793
43Folate biosynthesis_Homo sapiens_hsa007901.38068015
44Fat digestion and absorption_Homo sapiens_hsa049751.35257395
45Tyrosine metabolism_Homo sapiens_hsa003501.31707093
46Staphylococcus aureus infection_Homo sapiens_hsa051501.25495207
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.22962794
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22452303
49Starch and sucrose metabolism_Homo sapiens_hsa005001.19221643
50Fatty acid elongation_Homo sapiens_hsa000621.16715105
51Sulfur relay system_Homo sapiens_hsa041221.16297913
52One carbon pool by folate_Homo sapiens_hsa006701.09954186
53Arginine and proline metabolism_Homo sapiens_hsa003301.04255019
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02797618
55* ABC transporters_Homo sapiens_hsa020101.02442812
56Steroid biosynthesis_Homo sapiens_hsa001000.98228287
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91975999
58N-Glycan biosynthesis_Homo sapiens_hsa005100.91346271
59Pentose phosphate pathway_Homo sapiens_hsa000300.90898255
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.87474245
61Vitamin digestion and absorption_Homo sapiens_hsa049770.87235098
62Glycerolipid metabolism_Homo sapiens_hsa005610.86501421
63Glutathione metabolism_Homo sapiens_hsa004800.84794179
64Lysine degradation_Homo sapiens_hsa003100.81244138
65Synaptic vesicle cycle_Homo sapiens_hsa047210.77528855
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77430158
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72669826
68Vibrio cholerae infection_Homo sapiens_hsa051100.70519881
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62327222
70Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61217015
71Fatty acid biosynthesis_Homo sapiens_hsa000610.56219341
72Metabolic pathways_Homo sapiens_hsa011000.55658088
73ECM-receptor interaction_Homo sapiens_hsa045120.54327286
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54193036
75Fructose and mannose metabolism_Homo sapiens_hsa000510.53931013
76Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51296822
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.50825337
78HIF-1 signaling pathway_Homo sapiens_hsa040660.44829304
79Galactose metabolism_Homo sapiens_hsa000520.42370693
80Thyroid cancer_Homo sapiens_hsa052160.42066912
81Hippo signaling pathway_Homo sapiens_hsa043900.41252098
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40996181
83Axon guidance_Homo sapiens_hsa043600.38635902
84Basal cell carcinoma_Homo sapiens_hsa052170.38106591
85Nicotine addiction_Homo sapiens_hsa050330.35519089
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33260015
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32386014
88GABAergic synapse_Homo sapiens_hsa047270.31952060
89mRNA surveillance pathway_Homo sapiens_hsa030150.31427450
90Base excision repair_Homo sapiens_hsa034100.29413859
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.29244197
92Notch signaling pathway_Homo sapiens_hsa043300.28248810
93Prion diseases_Homo sapiens_hsa050200.27586208
94Alcoholism_Homo sapiens_hsa050340.25887099
95Adherens junction_Homo sapiens_hsa045200.25610927
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.25429431
97Insulin resistance_Homo sapiens_hsa049310.24951429
98Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24601568
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24299853
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23676739
101Glucagon signaling pathway_Homo sapiens_hsa049220.20938656
102Systemic lupus erythematosus_Homo sapiens_hsa053220.19910558
103AMPK signaling pathway_Homo sapiens_hsa041520.19066779
104Linoleic acid metabolism_Homo sapiens_hsa005910.18994827
105Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.14769601
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.14087708
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13719091
108Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.03983629
109Insulin signaling pathway_Homo sapiens_hsa049100.01418306
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.00484148
111Alzheimers disease_Homo sapiens_hsa05010-0.2232091
112Huntingtons disease_Homo sapiens_hsa05016-0.1994978
113Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1750148
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1530207
115Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1356379
116Oxidative phosphorylation_Homo sapiens_hsa00190-0.1281602
117Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1124503
118Renin-angiotensin system_Homo sapiens_hsa04614-0.1006905
119Parkinsons disease_Homo sapiens_hsa05012-0.0981076
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0638854
121Regulation of autophagy_Homo sapiens_hsa04140-0.0566944
122Bladder cancer_Homo sapiens_hsa05219-0.0508337
123Proteasome_Homo sapiens_hsa03050-0.0498722
124Pyrimidine metabolism_Homo sapiens_hsa00240-0.0231454

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »