ABCB7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a half-transporter involved in the transport of heme from the mitochondria to the cytosol. With iron/sulfur cluster precursors as its substrates, this protein may play a role in metal homeostasis. Mutations in this gene have been associated with mitochondrial iron accumulation and isodicentric (X)(q13) and sideroblastic anemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)6.58447545
2transcription from mitochondrial promoter (GO:0006390)6.03116025
3proline metabolic process (GO:0006560)5.71987708
4replication fork processing (GO:0031297)5.56814513
5embryonic process involved in female pregnancy (GO:0060136)5.36181814
6mitochondrial DNA metabolic process (GO:0032042)4.95379289
7sulfur amino acid catabolic process (GO:0000098)4.68236307
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.64782194
9maturation of 5.8S rRNA (GO:0000460)4.64518114
10negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.50222983
11negative regulation of fatty acid biosynthetic process (GO:0045717)4.49239612
12histone H4-K12 acetylation (GO:0043983)4.43426617
13CENP-A containing nucleosome assembly (GO:0034080)4.35383633
14chromatin remodeling at centromere (GO:0031055)4.27140379
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.26986769
16somatic diversification of immune receptors via somatic mutation (GO:0002566)4.26986769
17mitotic sister chromatid segregation (GO:0000070)4.20536957
18oxidative demethylation (GO:0070989)4.15499578
19embryonic placenta development (GO:0001892)4.12801222
20protein localization to kinetochore (GO:0034501)3.99548333
21IMP biosynthetic process (GO:0006188)3.98452062
22mitotic nuclear envelope disassembly (GO:0007077)3.94699187
23positive regulation of protein homooligomerization (GO:0032464)3.94589271
24purine nucleobase biosynthetic process (GO:0009113)3.90548955
25maturation of SSU-rRNA (GO:0030490)3.88807993
26L-ascorbic acid metabolic process (GO:0019852)3.82922420
27glutamine family amino acid biosynthetic process (GO:0009084)3.80347292
28regulation of nuclear cell cycle DNA replication (GO:0033262)3.74170359
29regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.73238219
30regulation of mitotic spindle checkpoint (GO:1903504)3.73238219
31histone exchange (GO:0043486)3.71493097
32regulation of integrin activation (GO:0033623)3.71057968
33sister chromatid segregation (GO:0000819)3.70316703
34ribosome assembly (GO:0042255)3.69753275
35cullin deneddylation (GO:0010388)3.67996013
36IMP metabolic process (GO:0046040)3.63677575
37membrane disassembly (GO:0030397)3.62927655
38nuclear envelope disassembly (GO:0051081)3.62927655
39branched-chain amino acid catabolic process (GO:0009083)3.59481770
40negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.58408767
41positive regulation by host of viral transcription (GO:0043923)3.57852066
42establishment of integrated proviral latency (GO:0075713)3.55977224
43DNA strand renaturation (GO:0000733)3.54850696
44nucleobase biosynthetic process (GO:0046112)3.54415669
45formation of translation preinitiation complex (GO:0001731)3.53963987
46regulation of translational fidelity (GO:0006450)3.50084336
47mitochondrial DNA replication (GO:0006264)3.47324256
48attachment of spindle microtubules to kinetochore (GO:0008608)3.45221176
49histone H4-K5 acetylation (GO:0043981)3.43717120
50histone H4-K8 acetylation (GO:0043982)3.43717120
51RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40683825
52protein neddylation (GO:0045116)3.40138926
53polyketide metabolic process (GO:0030638)3.37062302
54doxorubicin metabolic process (GO:0044598)3.37062302
55daunorubicin metabolic process (GO:0044597)3.37062302
56rRNA transcription (GO:0009303)3.36054819
57erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.35898206
58L-phenylalanine metabolic process (GO:0006558)3.35898206
59protein deneddylation (GO:0000338)3.35166772
60proteasome assembly (GO:0043248)3.34660013
61regulation of helicase activity (GO:0051095)3.34028725
62trophectodermal cell differentiation (GO:0001829)3.33657790
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.31254247
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.31254247
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.31254247
66somite rostral/caudal axis specification (GO:0032525)3.31072471
67DNA strand elongation (GO:0022616)3.30648201
68regulation of protein homooligomerization (GO:0032462)3.30601402
69somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.30572688
70isotype switching (GO:0045190)3.30572688
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.30572688
72histone H2A acetylation (GO:0043968)3.28249643
73establishment of apical/basal cell polarity (GO:0035089)3.28037748
74coenzyme catabolic process (GO:0009109)3.27721029
75nuclear pore complex assembly (GO:0051292)3.26741349
76synapsis (GO:0007129)3.26267455
77mitotic G1 DNA damage checkpoint (GO:0031571)3.25135074
78DNA replication-independent nucleosome assembly (GO:0006336)3.24952503
79DNA replication-independent nucleosome organization (GO:0034724)3.24952503
80negative regulation of cell cycle G2/M phase transition (GO:1902750)3.24722104
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.21522332
82glyoxylate metabolic process (GO:0046487)3.21381609
83DNA ligation (GO:0006266)3.21116540
84negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20424788
85mitotic metaphase plate congression (GO:0007080)3.17849458
86telomere maintenance via semi-conservative replication (GO:0032201)3.16417489
87determination of adult lifespan (GO:0008340)3.16298040
88very-low-density lipoprotein particle assembly (GO:0034379)3.16234249
89mismatch repair (GO:0006298)3.16020844
90pentose metabolic process (GO:0019321)3.15946180
91DNA duplex unwinding (GO:0032508)3.15731945
92nuclear pore organization (GO:0006999)3.14953781
93positive regulation of developmental pigmentation (GO:0048087)3.14495356
94DNA geometric change (GO:0032392)3.13610515
95lysine metabolic process (GO:0006553)3.12383772
96lysine catabolic process (GO:0006554)3.12383772
97serine family amino acid catabolic process (GO:0009071)3.11778912
98alkaloid metabolic process (GO:0009820)3.11639635
99glycine metabolic process (GO:0006544)3.11417990
100regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.11350064
101non-recombinational repair (GO:0000726)3.09865288
102double-strand break repair via nonhomologous end joining (GO:0006303)3.09865288
103negative regulation of translational initiation (GO:0045947)3.09636186
104DNA unwinding involved in DNA replication (GO:0006268)3.09489743
105spindle checkpoint (GO:0031577)3.08575776
106oxidative phosphorylation (GO:0006119)3.08341338
107regulation of double-strand break repair (GO:2000779)3.07757759
108establishment of protein localization to mitochondrial membrane (GO:0090151)3.07180181
109mitotic spindle checkpoint (GO:0071174)3.06592239
110negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.06386321
111pre-miRNA processing (GO:0031054)3.05907066
112cellular modified amino acid catabolic process (GO:0042219)3.05856483
113DNA replication-dependent nucleosome organization (GO:0034723)3.04235422
114DNA replication-dependent nucleosome assembly (GO:0006335)3.04235422
115mRNA cleavage (GO:0006379)3.03705364
116cellular ketone body metabolic process (GO:0046950)3.02647760
117chromatin assembly (GO:0031497)3.02557311
118anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.02418460
119mitotic sister chromatid cohesion (GO:0007064)3.02109000
120negative regulation of DNA-dependent DNA replication (GO:2000104)3.01548085
121exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01506428
122pore complex assembly (GO:0046931)3.00136524
123positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99026514
124lactate metabolic process (GO:0006089)2.98898988
125metaphase plate congression (GO:0051310)2.98892031
126histone mRNA metabolic process (GO:0008334)2.98733001
127labyrinthine layer development (GO:0060711)2.98283006
128telomere maintenance via recombination (GO:0000722)2.96578712
129ribosomal small subunit assembly (GO:0000028)2.96073260
130mitochondrial RNA metabolic process (GO:0000959)2.95721642
131viral mRNA export from host cell nucleus (GO:0046784)2.94502737
132DNA strand elongation involved in DNA replication (GO:0006271)2.94106316
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.92500518
134regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.92500518
135DNA replication checkpoint (GO:0000076)2.92099261
136G1 DNA damage checkpoint (GO:0044783)2.91929420
137erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.91900195
138L-phenylalanine catabolic process (GO:0006559)2.91900195
139somatic diversification of immunoglobulins (GO:0016445)2.91899866
140regulation of sister chromatid cohesion (GO:0007063)2.90912199
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90768372
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90768372
143negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90768372
144negative regulation of mitotic sister chromatid separation (GO:2000816)2.90768372
145negative regulation of sister chromatid segregation (GO:0033046)2.90768372
146negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90641923
147negative regulation of ligase activity (GO:0051352)2.90641923
148somatic recombination of immunoglobulin gene segments (GO:0016447)2.90311283
149cysteine metabolic process (GO:0006534)2.89421048
150nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89339973
151negative regulation of chromosome segregation (GO:0051985)2.88744685
152response to X-ray (GO:0010165)2.88702987
153mitotic G1/S transition checkpoint (GO:0044819)2.88612281
154positive regulation of chromosome segregation (GO:0051984)2.88006477
155single strand break repair (GO:0000012)2.87886845
156pteridine-containing compound biosynthetic process (GO:0042559)2.87347901
157rRNA modification (GO:0000154)2.86594088
158establishment of viral latency (GO:0019043)2.86584569
159regulation of double-strand break repair via homologous recombination (GO:0010569)2.86556775
160folic acid-containing compound biosynthetic process (GO:0009396)2.85533377
161protein localization to chromosome, centromeric region (GO:0071459)2.84540166
162regulation of sister chromatid segregation (GO:0033045)2.83079165
163regulation of mitotic sister chromatid separation (GO:0010965)2.83079165
164regulation of mitotic sister chromatid segregation (GO:0033047)2.83079165
165meiotic chromosome segregation (GO:0045132)2.82971631
166intra-S DNA damage checkpoint (GO:0031573)2.82866975
167regulation of RNA export from nucleus (GO:0046831)2.82729454
168spliceosomal tri-snRNP complex assembly (GO:0000244)2.82673192
169protein K6-linked ubiquitination (GO:0085020)2.81250006
170dosage compensation (GO:0007549)2.80396028
171branched-chain amino acid metabolic process (GO:0009081)2.80316750
172ribosomal large subunit biogenesis (GO:0042273)2.80004267
173hypotonic response (GO:0006971)2.79817842
174regulation of posttranscriptional gene silencing (GO:0060147)2.78499344
175regulation of gene silencing by miRNA (GO:0060964)2.78499344
176regulation of gene silencing by RNA (GO:0060966)2.78499344
177mitotic recombination (GO:0006312)2.78267243
178base-excision repair (GO:0006284)2.77776582
179biotin metabolic process (GO:0006768)2.76180926
180hormone catabolic process (GO:0042447)2.74379306
181DNA demethylation (GO:0080111)2.73944604
182kynurenine metabolic process (GO:0070189)2.73645177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.21856754
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.98435414
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.98435414
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.98435414
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.72121581
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.36693021
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.30010230
8ELK1_19687146_ChIP-ChIP_HELA_Human3.06040422
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.03026809
10NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.76255575
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.69498503
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65072958
13SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.63348133
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.60720604
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.58081617
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.54485997
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42247353
18VDR_23849224_ChIP-Seq_CD4+_Human2.38528819
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.36953515
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.36043736
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.31887334
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.31223819
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29271341
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.25301007
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.23824980
26ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18053845
27TCF3_18692474_ChIP-Seq_MEFs_Mouse2.17656771
28RXR_22158963_ChIP-Seq_LIVER_Mouse2.14125477
29MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09139452
30PADI4_21655091_ChIP-ChIP_MCF-7_Human2.07913995
31BP1_19119308_ChIP-ChIP_Hs578T_Human2.05620305
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02811938
33POU5F1_16518401_ChIP-PET_MESCs_Mouse2.01893267
34FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01549612
35EWS_26573619_Chip-Seq_HEK293_Human2.00449907
36EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99727776
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91990861
38STAT3_1855785_ChIP-Seq_MESCs_Mouse1.90374612
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.87914164
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78678764
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75619472
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.75166445
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75098246
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73238367
45NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.72859223
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70214138
47NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.68272432
48IGF1R_20145208_ChIP-Seq_DFB_Human1.67717486
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.67076068
50SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.65452029
51FUS_26573619_Chip-Seq_HEK293_Human1.64622444
52MYC_22102868_ChIP-Seq_BL_Human1.62945532
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.60629247
54ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59578724
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56568634
56IRF1_19129219_ChIP-ChIP_H3396_Human1.55784046
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55602659
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.55499973
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55298682
60LXR_22158963_ChIP-Seq_LIVER_Mouse1.55114494
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53630504
62MYC_18940864_ChIP-ChIP_HL60_Human1.49360459
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46829586
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.45778566
65TTF2_22483619_ChIP-Seq_HELA_Human1.44897008
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.43602650
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43195858
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.42653370
69MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42474284
70POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.39609699
71VDR_22108803_ChIP-Seq_LS180_Human1.38389101
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.37735822
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.37171895
74NANOG_18692474_ChIP-Seq_MESCs_Mouse1.37056453
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.35982249
76CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33648629
77ZNF274_21170338_ChIP-Seq_K562_Hela1.33022065
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.32318771
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.31812723
80EGR1_23403033_ChIP-Seq_LIVER_Mouse1.30301035
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30259935
82GABP_19822575_ChIP-Seq_HepG2_Human1.30002532
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29175130
84SOX2_18692474_ChIP-Seq_MESCs_Mouse1.27953656
85VDR_21846776_ChIP-Seq_THP-1_Human1.27707259
86ESR1_15608294_ChIP-ChIP_MCF-7_Human1.24884167
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24159128
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23261551
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.21830712
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20781310
91SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20587083
92NANOG_18692474_ChIP-Seq_MEFs_Mouse1.20336257
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19754237
94ZNF263_19887448_ChIP-Seq_K562_Human1.18566626
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.18073530
96SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16865010
97CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16644154
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16263913
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.15251465
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14457297
101E2F1_21310950_ChIP-Seq_MCF-7_Human1.14334210
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.14211778
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13296493
104* SOX2_16153702_ChIP-ChIP_HESCs_Human1.12821123
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.12791601
106P300_19829295_ChIP-Seq_ESCs_Human1.12527663
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.11472163
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.11145903
109KDM5A_27292631_Chip-Seq_BREAST_Human1.09868558
110* NANOG_16153702_ChIP-ChIP_HESCs_Human1.09605946
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09597199
112KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06169478
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05399950
114ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04876271
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04822084
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04087922
117RXRA_24833708_ChIP-Seq_LIVER_Mouse1.03796388
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.01228246
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00619633
120HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99511991
121CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98997584
122ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97839654
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96625180
124EST1_17652178_ChIP-ChIP_JURKAT_Human0.95596555
125TAF15_26573619_Chip-Seq_HEK293_Human0.94377502
126MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.92627044
127E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92594822
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92012256
129CREB1_15753290_ChIP-ChIP_HEK293T_Human0.90967710
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90355237
131TFEB_21752829_ChIP-Seq_HELA_Human0.89270947
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.88288435
133ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88031677
134JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87507456
135AR_21909140_ChIP-Seq_LNCAP_Human0.87274685
136KAP1_27257070_Chip-Seq_ESCs_Mouse0.86273896
137SOX2_19829295_ChIP-Seq_ESCs_Human0.85304484
138NANOG_19829295_ChIP-Seq_ESCs_Human0.85304484
139MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.85235925
140DCP1A_22483619_ChIP-Seq_HELA_Human0.85069515
141PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84896610
142CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.84815724
143PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84195076
144* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83895879
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.83468134
146KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82819466
147POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82453343
148ELK1_22589737_ChIP-Seq_MCF10A_Human0.81675650
149TP53_22573176_ChIP-Seq_HFKS_Human0.81604883
150ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.80491741
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80235191
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.79813797
153FOXP3_21729870_ChIP-Seq_TREG_Human0.78824379
154ER_23166858_ChIP-Seq_MCF-7_Human0.78465841
155XRN2_22483619_ChIP-Seq_HELA_Human0.77436031
156CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77265863
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.76937453
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.76879357
159CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.74254572

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.40122417
2MP0005085_abnormal_gallbladder_physiolo3.78640559
3MP0003890_abnormal_embryonic-extraembry3.73588718
4MP0002139_abnormal_hepatobiliary_system3.25060756
5MP0005360_urolithiasis3.20434842
6MP0005365_abnormal_bile_salt3.09761127
7MP0008877_abnormal_DNA_methylation2.97071468
8MP0005075_abnormal_melanosome_morpholog2.71406655
9MP0004957_abnormal_blastocyst_morpholog2.70392266
10MP0009697_abnormal_copulation2.59904855
11MP0003806_abnormal_nucleotide_metabolis2.57857150
12MP0004264_abnormal_extraembryonic_tissu2.56088614
13MP0010094_abnormal_chromosome_stability2.47456312
14MP0004147_increased_porphyrin_level2.37509637
15MP0002102_abnormal_ear_morphology2.31223493
16MP0008875_abnormal_xenobiotic_pharmacok2.29972675
17MP0005171_absent_coat_pigmentation2.24721287
18MP0003011_delayed_dark_adaptation2.19963885
19MP0005084_abnormal_gallbladder_morpholo2.15077731
20MP0002009_preneoplasia2.13910210
21MP0010352_gastrointestinal_tract_polyps2.10473312
22MP0010030_abnormal_orbit_morphology2.05424699
23MP0002837_dystrophic_cardiac_calcinosis2.02724383
24MP0008007_abnormal_cellular_replicative1.93009477
25MP0002332_abnormal_exercise_endurance1.87644673
26MP0003111_abnormal_nucleus_morphology1.81832108
27MP0005266_abnormal_metabolism1.78763906
28MP0002938_white_spotting1.73168049
29MP0003077_abnormal_cell_cycle1.70749234
30* MP0002086_abnormal_extraembryonic_tissu1.67271870
31* MP0005380_embryogenesis_phenotype1.65131579
32* MP0001672_abnormal_embryogenesis/_devel1.65131579
33MP0006035_abnormal_mitochondrial_morpho1.63706782
34MP0001293_anophthalmia1.62836806
35MP0003656_abnormal_erythrocyte_physiolo1.62190507
36MP0006292_abnormal_olfactory_placode1.57663515
37MP0008058_abnormal_DNA_repair1.53117597
38MP0004084_abnormal_cardiac_muscle1.51171826
39MP0004133_heterotaxia1.48230675
40MP0009278_abnormal_bone_marrow1.43726503
41MP0002269_muscular_atrophy1.42299092
42MP0004197_abnormal_fetal_growth/weight/1.42076169
43* MP0003984_embryonic_growth_retardation1.39550672
44MP0004215_abnormal_myocardial_fiber1.39335091
45* MP0002088_abnormal_embryonic_growth/wei1.37408165
46MP0003252_abnormal_bile_duct1.37001911
47MP0000609_abnormal_liver_physiology1.36775164
48MP0002084_abnormal_developmental_patter1.35820674
49MP0000350_abnormal_cell_proliferation1.33508494
50MP0001697_abnormal_embryo_size1.33114358
51MP0001730_embryonic_growth_arrest1.32731449
52MP0000372_irregular_coat_pigmentation1.32711404
53MP0002396_abnormal_hematopoietic_system1.31486272
54MP0000569_abnormal_digit_pigmentation1.27989707
55MP0006082_CNS_inflammation1.25443303
56MP0003172_abnormal_lysosome_physiology1.24815162
57MP0001764_abnormal_homeostasis1.24458821
58MP0002085_abnormal_embryonic_tissue1.22788693
59MP0002006_tumorigenesis1.22165778
60MP0002249_abnormal_larynx_morphology1.22012570
61MP0006036_abnormal_mitochondrial_physio1.21941850
62MP0008932_abnormal_embryonic_tissue1.21631479
63MP0000490_abnormal_crypts_of1.19348501
64MP0003453_abnormal_keratinocyte_physiol1.18897080
65MP0005332_abnormal_amino_acid1.17939305
66MP0003786_premature_aging1.16902621
67MP0002254_reproductive_system_inflammat1.16552785
68MP0003950_abnormal_plasma_membrane1.16136769
69MP0003693_abnormal_embryo_hatching1.15237878
70MP0003941_abnormal_skin_development1.13036096
71MP0001929_abnormal_gametogenesis1.12751391
72MP0001545_abnormal_hematopoietic_system1.10764552
73MP0005397_hematopoietic_system_phenotyp1.10764552
74MP0005408_hypopigmentation1.10746647
75MP0004233_abnormal_muscle_weight1.10460212
76MP0000371_diluted_coat_color1.10133250
77MP0002970_abnormal_white_adipose1.09700836
78MP0008995_early_reproductive_senescence1.09382791
79MP0010329_abnormal_lipoprotein_level1.07671260
80MP0003718_maternal_effect1.07669242
81MP0004142_abnormal_muscle_tone1.06824283
82MP0009115_abnormal_fat_cell1.04905292
83MP0003119_abnormal_digestive_system1.03664048
84MP0010307_abnormal_tumor_latency1.03626812
85MP0001529_abnormal_vocalization1.03034403
86MP0004145_abnormal_muscle_electrophysio1.02709849
87MP0004019_abnormal_vitamin_homeostasis1.02236206
88MP0002210_abnormal_sex_determination1.00988849
89* MP0005319_abnormal_enzyme/_coenzyme1.00824256
90MP0003937_abnormal_limbs/digits/tail_de1.00783668
91MP0004036_abnormal_muscle_relaxation0.97613345
92MP0002751_abnormal_autonomic_nervous0.97110072
93MP0005376_homeostasis/metabolism_phenot0.96598271
94MP0000427_abnormal_hair_cycle0.96202992
95MP0003646_muscle_fatigue0.95580467
96MP0010234_abnormal_vibrissa_follicle0.94545632
97MP0002092_abnormal_eye_morphology0.94432927
98* MP0002080_prenatal_lethality0.93790648
99MP0002090_abnormal_vision0.92091968
100MP0000653_abnormal_sex_gland0.92028881
101MP0008789_abnormal_olfactory_epithelium0.91613515
102MP0002019_abnormal_tumor_incidence0.90895845
103MP0001661_extended_life_span0.90478001
104MP0003137_abnormal_impulse_conducting0.90031339
105MP0001119_abnormal_female_reproductive0.89676573
106MP0001324_abnormal_eye_pigmentation0.89446793
107MP0001145_abnormal_male_reproductive0.88760722
108* MP0005395_other_phenotype0.88639795
109MP0005220_abnormal_exocrine_pancreas0.88307093
110MP0009703_decreased_birth_body0.87571672
111MP0000313_abnormal_cell_death0.86564697
112MP0003283_abnormal_digestive_organ0.85698343
113MP0004043_abnormal_pH_regulation0.85473988
114MP0002932_abnormal_joint_morphology0.83213764
115MP0000762_abnormal_tongue_morphology0.82831008
116MP0001984_abnormal_olfaction0.82733790
117MP0002163_abnormal_gland_morphology0.82452142
118MP0002233_abnormal_nose_morphology0.81029996
119MP0003705_abnormal_hypodermis_morpholog0.80797556
120MP0006072_abnormal_retinal_apoptosis0.80695006
121MP0003943_abnormal_hepatobiliary_system0.80266127
122MP0002075_abnormal_coat/hair_pigmentati0.79919117
123* MP0000598_abnormal_liver_morphology0.79534186
124MP0000647_abnormal_sebaceous_gland0.78037833
125MP0005248_abnormal_Harderian_gland0.77760142
126MP0005330_cardiomyopathy0.77710616
127MP0001286_abnormal_eye_development0.76796737
128MP0005391_vision/eye_phenotype0.76680727
129MP0003186_abnormal_redox_activity0.76064518
130MP0002111_abnormal_tail_morphology0.75730870
131MP0004808_abnormal_hematopoietic_stem0.75542703
132MP0001666_abnormal_nutrient_absorption0.74709083
133MP0003567_abnormal_fetal_cardiomyocyte0.74512224
134MP0000358_abnormal_cell_content/0.74333117
135MP0008775_abnormal_heart_ventricle0.72299361
136MP0003787_abnormal_imprinting0.72151200
137MP0000537_abnormal_urethra_morphology0.71758193
138MP0005076_abnormal_cell_differentiation0.71608891
139MP0008770_decreased_survivor_rate0.71153574
140MP0003136_yellow_coat_color0.70948268
141MP0003121_genomic_imprinting0.70431955
142MP0002127_abnormal_cardiovascular_syste0.70181705
143MP0002166_altered_tumor_susceptibility0.69614850
144MP0000689_abnormal_spleen_morphology0.69339811
145MP0002114_abnormal_axial_skeleton0.67738998
146MP0003698_abnormal_male_reproductive0.66625938
147MP0000631_abnormal_neuroendocrine_gland0.66623039
148MP0010678_abnormal_skin_adnexa0.66616913
149MP0005394_taste/olfaction_phenotype0.66199342
150MP0005499_abnormal_olfactory_system0.66199342
151MP0002234_abnormal_pharynx_morphology0.65849269
152MP0000516_abnormal_urinary_system0.65653366
153MP0005367_renal/urinary_system_phenotyp0.65653366
154MP0008873_increased_physiological_sensi0.65340730
155MP0005253_abnormal_eye_physiology0.64524610

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.46548171
2Rectovaginal fistula (HP:0000143)4.75618950
3Rectal fistula (HP:0100590)4.75618950
4Reduced antithrombin III activity (HP:0001976)4.54693679
5* Hypochromic microcytic anemia (HP:0004840)4.44371949
6Vaginal fistula (HP:0004320)4.25210889
7Intestinal fistula (HP:0100819)4.19815633
8Bilateral microphthalmos (HP:0007633)4.03621643
9Type I transferrin isoform profile (HP:0003642)4.00604952
10Colon cancer (HP:0003003)3.87917611
11Intrahepatic cholestasis (HP:0001406)3.79443837
12Abnormality of the lower motor neuron (HP:0002366)3.69598403
13Pancreatic islet-cell hyperplasia (HP:0004510)3.66430383
14Hypobetalipoproteinemia (HP:0003563)3.53175822
15Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.51098505
16Abnormal protein N-linked glycosylation (HP:0012347)3.51098505
17Abnormal protein glycosylation (HP:0012346)3.51098505
18Abnormal glycosylation (HP:0012345)3.51098505
19Short humerus (HP:0005792)3.45961960
20Abnormality of chromosome stability (HP:0003220)3.45162078
21Aplasia/hypoplasia of the humerus (HP:0006507)3.38615357
22Volvulus (HP:0002580)3.30136995
23Rhabdomyosarcoma (HP:0002859)3.29121020
24Ependymoma (HP:0002888)3.18480308
25Meckel diverticulum (HP:0002245)3.15005186
26Hypoproteinemia (HP:0003075)3.12424426
27Multiple enchondromatosis (HP:0005701)3.07325628
28Abnormality of monocarboxylic acid metabolism (HP:0010996)3.03434759
29Methylmalonic acidemia (HP:0002912)3.02209203
30Tongue fasciculations (HP:0001308)3.00220970
31Aplasia/Hypoplasia of the uvula (HP:0010293)2.98082337
32Facial hemangioma (HP:0000329)2.88267841
33Muscle fibrillation (HP:0010546)2.87298360
34Abnormality of the preputium (HP:0100587)2.87166185
35Concave nail (HP:0001598)2.85510054
36Neoplasm of striated muscle (HP:0009728)2.85098411
37Abnormal hemoglobin (HP:0011902)2.85033107
38Abnormality of DNA repair (HP:0003254)2.84153822
39Abnormality of aromatic amino acid family metabolism (HP:0004338)2.84024115
40Prolonged partial thromboplastin time (HP:0003645)2.81953631
41Acute necrotizing encephalopathy (HP:0006965)2.81634835
42Increased IgM level (HP:0003496)2.77852884
43Abnormal biliary tract physiology (HP:0012439)2.77457944
44Bile duct proliferation (HP:0001408)2.77457944
45Abnormality of the astrocytes (HP:0100707)2.77144003
46Astrocytoma (HP:0009592)2.77144003
47Broad alveolar ridges (HP:0000187)2.72126796
48Ulnar bowing (HP:0003031)2.68642484
49Annular pancreas (HP:0001734)2.65281345
50Acute encephalopathy (HP:0006846)2.63707659
51Embryonal renal neoplasm (HP:0011794)2.62819267
52Abnormality of lateral ventricle (HP:0030047)2.58980271
53Hyperinsulinemic hypoglycemia (HP:0000825)2.55913445
54Progressive macrocephaly (HP:0004481)2.55104533
55Abnormal mitochondria in muscle tissue (HP:0008316)2.53488559
56Nephroblastoma (Wilms tumor) (HP:0002667)2.53446858
57Duodenal stenosis (HP:0100867)2.53276736
58Small intestinal stenosis (HP:0012848)2.53276736
59Reticulocytopenia (HP:0001896)2.52496494
60Exercise-induced muscle cramps (HP:0003710)2.51427884
61Increased CSF lactate (HP:0002490)2.50086790
62Turricephaly (HP:0000262)2.48957268
63Cerebral edema (HP:0002181)2.48670441
64Abnormality of the pons (HP:0007361)2.48589417
65Impulsivity (HP:0100710)2.47228059
66Hepatoblastoma (HP:0002884)2.47126020
67Hypokinesia (HP:0002375)2.45319574
68Pustule (HP:0200039)2.42787344
69Gonadotropin excess (HP:0000837)2.41467424
70Hypoglycemic coma (HP:0001325)2.40518884
71Renal cortical cysts (HP:0000803)2.40507731
72Hyperglycinuria (HP:0003108)2.38546485
73Abnormality of the intrinsic pathway (HP:0010989)2.34134167
74Pseudobulbar signs (HP:0002200)2.34062893
75IgM deficiency (HP:0002850)2.32971912
76Abnormality of the duodenum (HP:0002246)2.32178841
77Methylmalonic aciduria (HP:0012120)2.29878241
78Abnormality of the pancreatic islet cells (HP:0006476)2.29841374
79Abnormality of endocrine pancreas physiology (HP:0012093)2.29841374
80Sloping forehead (HP:0000340)2.28648744
81Clubbing of toes (HP:0100760)2.28612821
82Absent radius (HP:0003974)2.27144399
83Hyperammonemia (HP:0001987)2.26749171
84Malnutrition (HP:0004395)2.26740461
85Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.26698271
86Hypolipoproteinemia (HP:0010981)2.26162117
87Mitochondrial inheritance (HP:0001427)2.25525654
88Orthostatic hypotension (HP:0001278)2.23791152
89Myelodysplasia (HP:0002863)2.22410156
90Triphalangeal thumb (HP:0001199)2.21655123
91Poikiloderma (HP:0001029)2.21474701
92Large earlobe (HP:0009748)2.21319510
93Abnormality of the salivary glands (HP:0010286)2.20715312
94Xanthomatosis (HP:0000991)2.19486022
95Deep venous thrombosis (HP:0002625)2.19074245
96Abnormality of the renal cortex (HP:0011035)2.16560562
97Hepatic necrosis (HP:0002605)2.15974561
98Neoplasm of the oral cavity (HP:0100649)2.13249955
99Vertebral fusion (HP:0002948)2.12248572
100Tetraplegia (HP:0002445)2.11315581
101Hypoplasia of the pons (HP:0012110)2.10372203
102Aplasia involving forearm bones (HP:0009822)2.06498864
103Absent forearm bone (HP:0003953)2.06498864
104Pancreatic cysts (HP:0001737)2.06301608
105Abnormality of methionine metabolism (HP:0010901)2.05147577
106Glioma (HP:0009733)2.04291546
107Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.04133752
108Vertebral hypoplasia (HP:0008417)2.04133752
109Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03287709
110Abnormality of alanine metabolism (HP:0010916)2.03287709
111Hyperalaninemia (HP:0003348)2.03287709
112Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02634225
113Pancreatic fibrosis (HP:0100732)2.01886509
114Abnormality of glycolysis (HP:0004366)2.01861948
115Increased serum pyruvate (HP:0003542)2.01162315
116Lipid accumulation in hepatocytes (HP:0006561)2.00966293
117Abnormal biliary tract morphology (HP:0012440)2.00354121
118Abnormal hair whorl (HP:0010721)1.99812839
119Dysautonomia (HP:0002459)1.99481760
120Abnormality of chromosome segregation (HP:0002916)1.99342110
121Chromsome breakage (HP:0040012)1.99247850
122Alopecia of scalp (HP:0002293)1.99002736
123Progressive muscle weakness (HP:0003323)1.98552901
124Horizontal nystagmus (HP:0000666)1.98021810
125Posterior subcapsular cataract (HP:0007787)1.97993201
126Large for gestational age (HP:0001520)1.97721008
127Upper motor neuron abnormality (HP:0002127)1.97576792
128Myocardial infarction (HP:0001658)1.97149826
129Abnormal lung lobation (HP:0002101)1.96638925
130Biliary tract neoplasm (HP:0100574)1.96551055
131Tented upper lip vermilion (HP:0010804)1.96201221
132Abnormality of the anterior horn cell (HP:0006802)1.95893082
133Degeneration of anterior horn cells (HP:0002398)1.95893082
134Abnormality of sulfur amino acid metabolism (HP:0004339)1.95655492
135Fat malabsorption (HP:0002630)1.95219731
136Abnormality of serine family amino acid metabolism (HP:0010894)1.94314804
137Abnormality of glycine metabolism (HP:0010895)1.94314804
138Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94224262
139Abnormal cartilage morphology (HP:0002763)1.93965028
140Abnormality of the labia minora (HP:0012880)1.93878390
141Increased hepatocellular lipid droplets (HP:0006565)1.93592626
142Abnormality of pyrimidine metabolism (HP:0004353)1.93338742
143Shawl scrotum (HP:0000049)1.93203195
144Hepatocellular necrosis (HP:0001404)1.92183739
145Intestinal atresia (HP:0011100)1.91682336
146Absent thumb (HP:0009777)1.91523667
147Anteriorly placed anus (HP:0001545)1.91184615
148Neoplasm of the colon (HP:0100273)1.90633355
149Abnormality of serum amino acid levels (HP:0003112)1.88630176
150Ketoacidosis (HP:0001993)1.88224123
151Dicarboxylic aciduria (HP:0003215)1.87973264
152Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87973264
153Abnormality of the ileum (HP:0001549)1.87612951
154Poor head control (HP:0002421)1.87480395
155Duplicated collecting system (HP:0000081)1.87220657
156Spastic diplegia (HP:0001264)1.86871837
157Agnosia (HP:0010524)1.85414547
158Lactic acidosis (HP:0003128)1.85273157
159Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83957468
160Short chin (HP:0000331)1.83118438
161Hypoglycemic seizures (HP:0002173)1.82830664
162Abnormality of the vitamin B12 metabolism (HP:0004341)1.82820604
163Missing ribs (HP:0000921)1.82029484
164Fused cervical vertebrae (HP:0002949)1.81982609
165Palpitations (HP:0001962)1.81596245
166Increased serum lactate (HP:0002151)1.80139176
167Microvesicular hepatic steatosis (HP:0001414)1.80072798
168CNS demyelination (HP:0007305)1.78876352
169Epidermoid cyst (HP:0200040)1.78797053
170Basal cell carcinoma (HP:0002671)1.77398552
171Ketosis (HP:0001946)1.77369673
172Exercise intolerance (HP:0003546)1.77257220
173Polycythemia (HP:0001901)1.76208006
174Medulloblastoma (HP:0002885)1.76032659
175Squamous cell carcinoma (HP:0002860)1.75517407
176Abnormal number of incisors (HP:0011064)1.74545945
177Abnormality of vitamin B metabolism (HP:0004340)1.72898850
178Abnormal spermatogenesis (HP:0008669)1.72677237
179Generalized aminoaciduria (HP:0002909)1.71952426

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.42039666
2ICK4.27494704
3EIF2AK34.05349546
4BUB13.71112899
5MATK3.43685103
6TYRO33.24551879
7CDK193.16818138
8MAP3K63.15791692
9DDR23.11267597
10NUAK12.95524002
11MST42.94346846
12TSSK62.88892880
13ZAK2.81504840
14FGR2.72543659
15MKNK12.60197123
16MAPK152.53803799
17PINK12.43183352
18EIF2AK12.35593562
19PLK32.31166954
20PBK2.31078525
21VRK22.29809865
22GRK62.25311599
23CSK2.18889582
24BMX2.14874615
25GRK52.06877703
26SRPK12.03492133
27TRIM281.97664647
28CDK71.93764876
29AKT31.91622952
30TTK1.91050164
31MKNK21.90715941
32FRK1.81535555
33TAF11.78408890
34BMPR1B1.76115355
35CSF1R1.76089128
36VRK11.75205773
37PDK21.73119577
38PLK41.70022979
39PASK1.68274857
40PIM21.66506963
41MAP3K111.61562707
42STK101.58291133
43CDK61.53423550
44DYRK1B1.48006397
45YES11.47599349
46CDC71.41867855
47MAP3K101.41714568
48OBSCN1.40505392
49PRKD21.37524736
50STK161.37116243
51UHMK11.35911055
52CHEK21.35724735
53WNK31.33795936
54GRK11.31481252
55MAP4K21.28832225
56PDGFRA1.28830523
57PLK11.27287419
58PIM11.26051479
59OXSR11.25115942
60ERBB31.21975231
61SCYL21.20307721
62WEE11.18677057
63DAPK11.14825687
64BCR1.11592538
65MAPK111.11219062
66ERN11.10714064
67NEK91.08738308
68MAPK71.04550496
69TNIK1.03529801
70HIPK21.01821287
71BRD41.00587976
72TRPM70.97433034
73ADRBK20.96858244
74TGFBR20.96811857
75EIF2AK20.94168853
76GSK3A0.93822840
77RPS6KA40.92507526
78CHEK10.91206952
79ALK0.87682038
80PRKAA10.83544220
81GRK70.83271993
82CSNK1G10.81855223
83TIE10.79500845
84MTOR0.79136079
85EPHA20.77900539
86CDK20.76663879
87PIK3CG0.74598786
88BRSK20.74184138
89FGFR20.73078226
90PLK20.72077672
91RPS6KB20.70599670
92RPS6KC10.69189403
93RPS6KL10.69189403
94ATM0.67925537
95ATR0.67165006
96PHKG10.66615113
97PHKG20.66615113
98CSNK1G30.66387172
99CDC42BPA0.65902760
100CCNB10.65671882
101NEK20.65640403
102CDK30.65420365
103NEK10.63273354
104CLK10.62458854
105MAPK40.61706883
106LATS20.61314839
107AURKB0.60802142
108CDK40.58983807
109NME10.58972994
110PRKAA20.57257418
111ACVR1B0.56555490
112KDR0.56063149
113RPS6KA50.54801969
114WNK10.54470416
115BCKDK0.54415261
116CAMK40.54127532
117CDK80.51744546
118STK390.51191191
119CSNK1A1L0.51109201
120MAP3K40.50902614
121NLK0.50108883
122EGFR0.50017934
123MET0.49837959
124RPS6KA60.49344067
125MARK20.49307209
126CDK10.47432982
127AKT20.44049081
128STK38L0.43780721
129MAPK140.43355203
130FLT30.42865123
131STK30.42761179
132CSNK1G20.42663168
133MAPK100.41930485
134MAP3K70.41430913
135INSR0.39936160
136DYRK30.39681713
137RPS6KA10.39353709
138MAPK10.38726303
139CSNK1E0.38714884
140TAOK30.37842754
141STK40.37631354
142CSNK2A20.36837955
143CSNK2A10.36665551
144PRKDC0.36091278
145PRKG20.35660885
146AURKA0.33823176
147PRKACG0.33285436
148MAP2K40.33094256
149RPS6KA30.32953793
150STK240.32477977
151MELK0.32142267
152RPS6KB10.30775016
153BRSK10.29909615
154FGFR10.29420000
155MAP3K80.29034417
156NME20.28761592
157TGFBR10.28307437
158RIPK10.28066669
159MAPK30.27631408
160GSK3B0.27519370
161RAF10.27254503
162BMPR20.26254687
163DMPK0.25233635
164TEC0.24957724

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.36729203
2Mismatch repair_Homo sapiens_hsa034303.09021950
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03807926
4Fatty acid biosynthesis_Homo sapiens_hsa000613.03659424
5Nitrogen metabolism_Homo sapiens_hsa009102.72471767
6DNA replication_Homo sapiens_hsa030302.66737976
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.65257222
8Protein export_Homo sapiens_hsa030602.59097239
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57883375
10Arginine biosynthesis_Homo sapiens_hsa002202.56045387
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49313678
12Base excision repair_Homo sapiens_hsa034102.40010649
13Vitamin B6 metabolism_Homo sapiens_hsa007502.32272567
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.27495476
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.25558643
16RNA polymerase_Homo sapiens_hsa030202.23288049
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.18461905
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.13210027
19Biosynthesis of amino acids_Homo sapiens_hsa012301.93504891
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88745318
21Folate biosynthesis_Homo sapiens_hsa007901.88536881
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.86454241
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84922923
24Basal transcription factors_Homo sapiens_hsa030221.81909051
25Fatty acid metabolism_Homo sapiens_hsa012121.80878582
26Tryptophan metabolism_Homo sapiens_hsa003801.77896913
27Fructose and mannose metabolism_Homo sapiens_hsa000511.70908378
28Oxidative phosphorylation_Homo sapiens_hsa001901.69341480
29Complement and coagulation cascades_Homo sapiens_hsa046101.66829823
30One carbon pool by folate_Homo sapiens_hsa006701.65859549
31Arginine and proline metabolism_Homo sapiens_hsa003301.56478975
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55622041
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54509394
34RNA transport_Homo sapiens_hsa030131.53077292
35Parkinsons disease_Homo sapiens_hsa050121.50701340
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.50122584
37Lysine degradation_Homo sapiens_hsa003101.42996968
38Fanconi anemia pathway_Homo sapiens_hsa034601.42195365
39Nucleotide excision repair_Homo sapiens_hsa034201.39388059
40Purine metabolism_Homo sapiens_hsa002301.34723012
41mTOR signaling pathway_Homo sapiens_hsa041501.31060679
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30269776
43Pyrimidine metabolism_Homo sapiens_hsa002401.28063907
44Homologous recombination_Homo sapiens_hsa034401.25510579
45mRNA surveillance pathway_Homo sapiens_hsa030151.24297623
46Selenocompound metabolism_Homo sapiens_hsa004501.21573639
47Spliceosome_Homo sapiens_hsa030401.20092639
48Fatty acid degradation_Homo sapiens_hsa000711.17539799
49Butanoate metabolism_Homo sapiens_hsa006501.13739615
50Sulfur relay system_Homo sapiens_hsa041221.12555985
51Galactose metabolism_Homo sapiens_hsa000521.11538332
52Chemical carcinogenesis_Homo sapiens_hsa052041.10704654
53Propanoate metabolism_Homo sapiens_hsa006401.09722093
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.09047713
55Carbon metabolism_Homo sapiens_hsa012001.08047318
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08019294
57Huntingtons disease_Homo sapiens_hsa050161.03952047
58Steroid biosynthesis_Homo sapiens_hsa001001.03628143
59Starch and sucrose metabolism_Homo sapiens_hsa005000.99753722
60Drug metabolism - other enzymes_Homo sapiens_hsa009830.98734261
61Fatty acid elongation_Homo sapiens_hsa000620.98418709
62Cell cycle_Homo sapiens_hsa041100.94907492
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92337691
64Bile secretion_Homo sapiens_hsa049760.91480622
65Peroxisome_Homo sapiens_hsa041460.90578440
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.87365803
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87010950
68N-Glycan biosynthesis_Homo sapiens_hsa005100.84621794
69beta-Alanine metabolism_Homo sapiens_hsa004100.84591496
70Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84577683
71Oocyte meiosis_Homo sapiens_hsa041140.82694713
72PPAR signaling pathway_Homo sapiens_hsa033200.82339365
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.81602019
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.76371083
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76127045
76p53 signaling pathway_Homo sapiens_hsa041150.75825742
77Linoleic acid metabolism_Homo sapiens_hsa005910.75776338
78Alzheimers disease_Homo sapiens_hsa050100.74706020
79RNA degradation_Homo sapiens_hsa030180.72589992
80Vitamin digestion and absorption_Homo sapiens_hsa049770.72494658
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72364817
82Glutathione metabolism_Homo sapiens_hsa004800.71464467
83Histidine metabolism_Homo sapiens_hsa003400.70763197
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70153181
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.67203745
86Pentose phosphate pathway_Homo sapiens_hsa000300.64658976
87Systemic lupus erythematosus_Homo sapiens_hsa053220.64537394
88Tyrosine metabolism_Homo sapiens_hsa003500.64437964
89Pyruvate metabolism_Homo sapiens_hsa006200.64233493
90Retinol metabolism_Homo sapiens_hsa008300.64179074
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.60124789
92Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59878405
93Staphylococcus aureus infection_Homo sapiens_hsa051500.58935289
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57949594
95Adherens junction_Homo sapiens_hsa045200.56915623
96Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55671234
97Caffeine metabolism_Homo sapiens_hsa002320.55520359
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52772287
99Ribosome_Homo sapiens_hsa030100.50794822
100Fat digestion and absorption_Homo sapiens_hsa049750.50747537
101Phenylalanine metabolism_Homo sapiens_hsa003600.48994210
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48693273
103Regulation of autophagy_Homo sapiens_hsa041400.48313124
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46932791
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46593802
106Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45746128
107Hedgehog signaling pathway_Homo sapiens_hsa043400.44855730
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44241541
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43996195
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.43236067
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41760857
112Notch signaling pathway_Homo sapiens_hsa043300.41193702
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41065625
114Non-homologous end-joining_Homo sapiens_hsa034500.40438886
115Metabolic pathways_Homo sapiens_hsa011000.39302850
116AMPK signaling pathway_Homo sapiens_hsa041520.39276697
117* ABC transporters_Homo sapiens_hsa020100.37161571
118Thyroid cancer_Homo sapiens_hsa052160.36502073
119Hippo signaling pathway_Homo sapiens_hsa043900.36137031
120Circadian rhythm_Homo sapiens_hsa047100.35991816
121Arachidonic acid metabolism_Homo sapiens_hsa005900.35911398
122Cardiac muscle contraction_Homo sapiens_hsa042600.34765378
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31249561
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28793014
125Epstein-Barr virus infection_Homo sapiens_hsa051690.26042395
126Alcoholism_Homo sapiens_hsa050340.18775892
127Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.11427999
128TGF-beta signaling pathway_Homo sapiens_hsa043500.07480704
129Legionellosis_Homo sapiens_hsa051340.06737779
130Herpes simplex infection_Homo sapiens_hsa051680.05952838

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