ABCB8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tricarboxylic acid cycle (GO:0006099)6.24686804
2mannose metabolic process (GO:0006013)5.46749798
3fatty acid beta-oxidation (GO:0006635)5.24024600
4lysine metabolic process (GO:0006553)5.12547891
5lysine catabolic process (GO:0006554)5.12547891
6aspartate family amino acid catabolic process (GO:0009068)5.04613131
7GDP-mannose metabolic process (GO:0019673)4.98482478
8branched-chain amino acid catabolic process (GO:0009083)4.96265740
9carnitine shuttle (GO:0006853)4.95869743
10NADH metabolic process (GO:0006734)4.91845731
11valine metabolic process (GO:0006573)4.90293732
122-oxoglutarate metabolic process (GO:0006103)4.85406409
13fatty acid catabolic process (GO:0009062)4.63827186
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62791688
15L-phenylalanine metabolic process (GO:0006558)4.62791688
16short-chain fatty acid metabolic process (GO:0046459)4.58466846
17succinate metabolic process (GO:0006105)4.55065444
18branched-chain amino acid metabolic process (GO:0009081)4.54034664
19fatty acid transmembrane transport (GO:1902001)4.53001548
20acetyl-CoA metabolic process (GO:0006084)4.52587766
21fatty acid oxidation (GO:0019395)4.50805278
22tricarboxylic acid metabolic process (GO:0072350)4.42741920
23lipid oxidation (GO:0034440)4.42319946
24L-phenylalanine catabolic process (GO:0006559)4.41508202
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.41508202
26negative regulation of cell size (GO:0045792)4.40826764
27carnitine metabolic process (GO:0009437)4.38955450
28negative regulation of erythrocyte differentiation (GO:0045647)4.32833781
29biotin metabolic process (GO:0006768)4.30779597
30proline biosynthetic process (GO:0006561)4.28253908
31mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.23763626
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.23216927
33alpha-linolenic acid metabolic process (GO:0036109)4.17649154
34glyoxylate metabolic process (GO:0046487)4.15443985
35thioester biosynthetic process (GO:0035384)4.14076810
36acyl-CoA biosynthetic process (GO:0071616)4.14076810
37carnitine transmembrane transport (GO:1902603)4.13337992
38carnitine transport (GO:0015879)4.09563018
39amino-acid betaine transport (GO:0015838)4.09563018
40monocarboxylic acid catabolic process (GO:0072329)4.09308491
41amino-acid betaine metabolic process (GO:0006577)4.07995976
42respiratory electron transport chain (GO:0022904)4.07436243
43oxidative phosphorylation (GO:0006119)4.04753119
44oxaloacetate metabolic process (GO:0006107)4.04300598
45fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.01313601
46apoptotic process involved in morphogenesis (GO:0060561)3.99619043
47electron transport chain (GO:0022900)3.98879994
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.97875022
49quinone biosynthetic process (GO:1901663)3.95382974
50ubiquinone biosynthetic process (GO:0006744)3.95382974
51UV protection (GO:0009650)3.93015666
52sarcomere organization (GO:0045214)3.89159250
53snRNA metabolic process (GO:0016073)3.88698009
54response to misfolded protein (GO:0051788)3.85500452
55semaphorin-plexin signaling pathway (GO:0071526)3.84507257
56positive regulation of histone deacetylation (GO:0031065)3.83850270
57Golgi transport vesicle coating (GO:0048200)3.81771914
58COPI coating of Golgi vesicle (GO:0048205)3.81771914
59creatine metabolic process (GO:0006600)3.80260640
60regulation of fatty acid oxidation (GO:0046320)3.78154319
61cellular ketone body metabolic process (GO:0046950)3.78051387
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77592941
63thioester metabolic process (GO:0035383)3.74533986
64acyl-CoA metabolic process (GO:0006637)3.74533986
65energy coupled proton transport, down electrochemical gradient (GO:0015985)3.74054410
66ATP synthesis coupled proton transport (GO:0015986)3.74054410
67regulation of sequestering of triglyceride (GO:0010889)3.65337966
68misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.63763581
69protein retention in ER lumen (GO:0006621)3.62726199
70ethanol oxidation (GO:0006069)3.58939604
71snRNA processing (GO:0016180)3.57639554
72ubiquinone metabolic process (GO:0006743)3.55885024
73quaternary ammonium group transport (GO:0015697)3.54847020
74regulation of acyl-CoA biosynthetic process (GO:0050812)3.54049509
75retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.48026443
76regulation of cholesterol biosynthetic process (GO:0045540)3.48005201
77regulation of cholesterol metabolic process (GO:0090181)3.44147416
78regulation of triglyceride catabolic process (GO:0010896)3.43381296
79carboxylic acid catabolic process (GO:0046395)3.43275991
80organic acid catabolic process (GO:0016054)3.43275991
81response to mercury ion (GO:0046689)3.42634514
82fatty-acyl-CoA biosynthetic process (GO:0046949)3.42476031
83ketone body metabolic process (GO:1902224)3.41990137
84sulfur amino acid catabolic process (GO:0000098)3.41522742
85protein insertion into membrane (GO:0051205)3.40628002
86maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.37729893
87proline metabolic process (GO:0006560)3.37100204
88fatty-acyl-CoA metabolic process (GO:0035337)3.33788697
89cardiac myofibril assembly (GO:0055003)3.33687788
90regulation of mammary gland epithelial cell proliferation (GO:0033599)3.33072336
91glucose 6-phosphate metabolic process (GO:0051156)3.28956041
92regulation of cofactor metabolic process (GO:0051193)3.28845506
93regulation of coenzyme metabolic process (GO:0051196)3.28845506
94aromatic amino acid family catabolic process (GO:0009074)3.28515668
95peptidyl-arginine omega-N-methylation (GO:0035247)3.27124508
96positive regulation of protein deacetylation (GO:0090312)3.26696066
97alpha-amino acid catabolic process (GO:1901606)3.25514163
98cellular amino acid catabolic process (GO:0009063)3.25212776
99cysteine metabolic process (GO:0006534)3.23587782
100serine family amino acid biosynthetic process (GO:0009070)3.23170228
101basement membrane organization (GO:0071711)3.22755544
102negative regulation of leukocyte chemotaxis (GO:0002689)3.21394091
103triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.18451103
104spliceosomal tri-snRNP complex assembly (GO:0000244)3.17750433
105negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16268714
106coenzyme catabolic process (GO:0009109)3.12852816
107coenzyme A metabolic process (GO:0015936)3.11326475
108positive regulation of fatty acid oxidation (GO:0046321)3.11250166
109cellular modified amino acid catabolic process (GO:0042219)3.10317912
110regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08675510
111cardiac muscle contraction (GO:0060048)3.08011719
112dicarboxylic acid catabolic process (GO:0043649)3.08002131
113kynurenine metabolic process (GO:0070189)3.07942584
114regulation of ARF GTPase activity (GO:0032312)3.07311425
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.06218281
116negative regulation of potassium ion transmembrane transport (GO:1901380)3.03972612
117positive regulation of fatty acid beta-oxidation (GO:0032000)3.02402479
118very long-chain fatty acid metabolic process (GO:0000038)3.00991967
119urinary tract smooth muscle contraction (GO:0014848)3.00418417
120L-serine metabolic process (GO:0006563)2.99843302
121NIK/NF-kappaB signaling (GO:0038061)2.97867862
122myofibril assembly (GO:0030239)2.97496193
123cardiolipin metabolic process (GO:0032048)2.97090078
124positive regulation of vascular permeability (GO:0043117)2.96883089
125cell migration in hindbrain (GO:0021535)2.96276538
126gluconeogenesis (GO:0006094)2.95632986
127endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.95293918
128small molecule catabolic process (GO:0044282)2.94956141
129long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.94480495
130glycine metabolic process (GO:0006544)2.94411808
131aspartate family amino acid metabolic process (GO:0009066)2.93550571
132drug transmembrane transport (GO:0006855)2.92587824
133mitochondrial fusion (GO:0008053)2.92268039
134phosphatidylglycerol biosynthetic process (GO:0006655)2.90400555
135cytoskeletal anchoring at plasma membrane (GO:0007016)2.90308432
136granulocyte differentiation (GO:0030851)2.89716638
137positive regulation of protein dephosphorylation (GO:0035307)2.89167352
138dicarboxylic acid metabolic process (GO:0043648)2.88931852
139atrioventricular valve morphogenesis (GO:0003181)2.88867448
140fatty acid homeostasis (GO:0055089)2.85923195
141regulation of fatty acid beta-oxidation (GO:0031998)2.85723775
142protein maturation by protein folding (GO:0022417)2.85436279
143intracellular estrogen receptor signaling pathway (GO:0030520)2.83519385
144synaptic vesicle exocytosis (GO:0016079)2.80698521
145negative regulation of autophagy (GO:0010507)2.80397661
146adherens junction assembly (GO:0034333)2.79396931
147regulation of glucose import in response to insulin stimulus (GO:2001273)2.78729782
148protein localization to endosome (GO:0036010)2.78601402
149urea cycle (GO:0000050)2.78455837
150peptidyl-arginine N-methylation (GO:0035246)2.78413739
151peptidyl-arginine methylation (GO:0018216)2.78413739
152positive regulation of synapse maturation (GO:0090129)2.78349421
153positive regulation of CREB transcription factor activity (GO:0032793)2.77130479
154modulation by virus of host process (GO:0019054)2.72573355
155barbed-end actin filament capping (GO:0051016)2.71484025
156cell-cell junction maintenance (GO:0045217)2.71230772
157positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.70689269
158retrograde transport, endosome to Golgi (GO:0042147)2.70234356
159positive regulation of action potential (GO:0045760)2.66896065
160mitotic nuclear envelope reassembly (GO:0007084)2.65400136
161nuclear envelope reassembly (GO:0031468)2.65400136
162activation of MAPKKK activity (GO:0000185)2.64823466
163adhesion of symbiont to host (GO:0044406)2.63716886
164erythrocyte maturation (GO:0043249)2.63240037
165urea metabolic process (GO:0019627)2.61052906
166cell-substrate adherens junction assembly (GO:0007045)2.60732183
167focal adhesion assembly (GO:0048041)2.60732183
168apoptotic process involved in development (GO:1902742)2.59708221
169activation of Rac GTPase activity (GO:0032863)2.58887995
170glutamine family amino acid biosynthetic process (GO:0009084)2.57057281
171regulation of ARF protein signal transduction (GO:0032012)2.55837706
172folic acid metabolic process (GO:0046655)2.55831334
173positive regulation of triglyceride biosynthetic process (GO:0010867)2.54346639
174negative regulation of viral release from host cell (GO:1902187)2.54128277
175behavioral response to pain (GO:0048266)2.54114653
176thymic T cell selection (GO:0045061)2.53138833
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.52803777
178ncRNA 3-end processing (GO:0043628)2.51406792
179amyloid precursor protein catabolic process (GO:0042987)2.50157044
180response to laminar fluid shear stress (GO:0034616)2.50150044
181regulation of early endosome to late endosome transport (GO:2000641)2.48898119
182negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.47473588
183endothelial cell chemotaxis (GO:0035767)2.47081664
184regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46877962
185modulation by symbiont of host cellular process (GO:0044068)2.46426696
186positive regulation of protein sumoylation (GO:0033235)2.45398307
187cell volume homeostasis (GO:0006884)2.45095631
188regulation of histone H3-K27 methylation (GO:0061085)2.44867504
189negative regulation of DNA-templated transcription, elongation (GO:0032785)2.43690875
190autophagic vacuole assembly (GO:0000045)2.43290376
191synaptic vesicle docking involved in exocytosis (GO:0016081)2.42993371
192regulation of translational fidelity (GO:0006450)2.41845085
193regulation of macrophage chemotaxis (GO:0010758)2.41165139
194vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.38117458

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.23956054
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.62546827
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.17025957
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.02178673
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.58706268
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.51987226
7* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.31877471
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.02020766
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80986479
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.67913111
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.61086308
12MYC_22102868_ChIP-Seq_BL_Human2.49542184
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.45003150
14ZNF263_19887448_ChIP-Seq_K562_Human2.42443858
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.35301489
16KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.23664390
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22004606
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18808504
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.16381085
20TP63_17297297_ChIP-ChIP_HaCaT_Human2.06918893
21KDM2B_26808549_Chip-Seq_DND41_Human2.05504945
22CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.94249925
23NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.92090102
24PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.91705858
25SRY_22984422_ChIP-ChIP_TESTIS_Rat1.89555007
26TCF7_22412390_ChIP-Seq_EML_Mouse1.75928881
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.73457316
28DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71828465
29HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66886398
30KDM2B_26808549_Chip-Seq_K562_Human1.66648651
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65523336
32UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.65186191
33* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64091543
34* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61747963
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61460301
36SRF_21415370_ChIP-Seq_HL-1_Mouse1.60757414
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59924359
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.59378862
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.57551715
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57491963
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.56808127
42MAF_26560356_Chip-Seq_TH2_Human1.56779403
43HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55349208
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54960227
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.53684955
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.52339449
47* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52092188
48MAF_26560356_Chip-Seq_TH1_Human1.49782250
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47480865
50LXR_22292898_ChIP-Seq_THP-1_Human1.45122412
51TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44738435
52TBX20_22080862_ChIP-Seq_HEART_Mouse1.44367031
53TBX20_22328084_ChIP-Seq_HEART_Mouse1.44367031
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44020151
55TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43967133
56* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43677389
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.41822749
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41438170
59P68_20966046_ChIP-Seq_HELA_Human1.39293930
60CREB1_26743006_Chip-Seq_LNCaP_Human1.37077924
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.32388984
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30341629
63NCOR1_26117541_ChIP-Seq_K562_Human1.30004173
64RARB_24833708_ChIP-Seq_LIVER_Mouse1.29888640
65VDR_24763502_ChIP-Seq_THP-1_Human1.29800589
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.29759663
67MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.29111851
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.28847153
69UTX_26944678_Chip-Seq_JUKART_Human1.28705615
70* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27515306
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.27495761
72VDR_21846776_ChIP-Seq_THP-1_Human1.26417035
73P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25597221
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25131564
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.25074771
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24658302
77* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24247242
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.23701863
79CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23183306
80* BCOR_27268052_Chip-Seq_Bcells_Human1.23161474
81SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21490724
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.21096291
83RARA_24833708_ChIP-Seq_LIVER_Mouse1.20904204
84* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18521742
85STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18435736
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18059162
87* SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.18013373
88* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17251923
89* BCL6_27268052_Chip-Seq_Bcells_Human1.16698449
90* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16448709
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.15662243
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15087003
93* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.14495346
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14275871
95* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.13629405
96SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12741294
97* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.12648746
98TP53_22127205_ChIP-Seq_IMR90_Human1.12197913
99* RUNX1_22412390_ChIP-Seq_EML_Mouse1.12076520
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11791267
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11107729
102ELF1_20517297_ChIP-Seq_JURKAT_Human1.11008446
103ATF3_27146783_Chip-Seq_COLON_Human1.10602410
104GATA1_19941826_ChIP-Seq_K562_Human1.09241155
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09031359
106CIITA_25753668_ChIP-Seq_RAJI_Human1.08395372
107TBX5_21415370_ChIP-Seq_HL-1_Mouse1.08365588
108TET1_21451524_ChIP-Seq_MESCs_Mouse1.08062661
109KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06570133
110XRN2_22483619_ChIP-Seq_HELA_Human1.05824824
111GATA1_22025678_ChIP-Seq_K562_Human1.05700295
112CLOCK_20551151_ChIP-Seq_293T_Human1.03854676
113KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03434508
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03308801
115STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02216485
116MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01401804
117RACK7_27058665_Chip-Seq_MCF-7_Human1.01202533
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99364407
119CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98769617
120EST1_17652178_ChIP-ChIP_JURKAT_Human0.98553961
121* RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98448007
122AR_21909140_ChIP-Seq_LNCAP_Human0.98260415
123* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98225250
124* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97282401
125CTCF_21964334_Chip-Seq_Bcells_Human0.94521045
126TP63_22573176_ChIP-Seq_HFKS_Human0.94480194
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93916020
128SCL_19346495_ChIP-Seq_HPC-7_Human0.93479569
129CTCF_27219007_Chip-Seq_Bcells_Human0.92984961
130GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92103082
131LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90251378
132EP300_21415370_ChIP-Seq_HL-1_Mouse0.90168673
133E2F1_20622854_ChIP-Seq_HELA_Human0.89864255
134FOXP1_21924763_ChIP-Seq_HESCs_Human0.88476714
135DNAJC2_21179169_ChIP-ChIP_NT2_Human0.87864697
136SMC4_20622854_ChIP-Seq_HELA_Human0.86780050
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.86102960
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.85949022
139* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.85933482
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85884325
141EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.84811051
142SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.84256207
143ERG_20517297_ChIP-Seq_VCAP_Human0.84117557
144CTCF_20526341_ChIP-Seq_ESCs_Human0.83654359
145P300_27268052_Chip-Seq_Bcells_Human0.83211639
146TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82395007
147PHF8_20622854_ChIP-Seq_HELA_Human0.82277514
148* CTCF_26484167_Chip-Seq_Bcells_Mouse0.81637841
149* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.81143338
150DCP1A_22483619_ChIP-Seq_HELA_Human0.80544339
151SA1_27219007_Chip-Seq_ERYTHROID_Human0.80211828
152SA1_27219007_Chip-Seq_Bcells_Human0.80116753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.71695415
2MP0003646_muscle_fatigue4.37537046
3MP0005360_urolithiasis3.93639051
4MP0003705_abnormal_hypodermis_morpholog3.89782393
5MP0003806_abnormal_nucleotide_metabolis3.66415583
6MP0002139_abnormal_hepatobiliary_system3.48429591
7MP0008875_abnormal_xenobiotic_pharmacok3.34643865
8MP0000751_myopathy3.17947698
9MP0005085_abnormal_gallbladder_physiolo3.15507098
10MP0004084_abnormal_cardiac_muscle3.01932416
11MP0008260_abnormal_autophagy2.95183938
12MP0005365_abnormal_bile_salt2.92802960
13MP0009840_abnormal_foam_cell2.82632061
14MP0005330_cardiomyopathy2.80451999
15MP0006036_abnormal_mitochondrial_physio2.79018096
16MP0004215_abnormal_myocardial_fiber2.77195519
17MP0003172_abnormal_lysosome_physiology2.68889294
18MP0004858_abnormal_nervous_system2.64536093
19MP0004036_abnormal_muscle_relaxation2.62401518
20MP0005332_abnormal_amino_acid2.50099932
21MP0004130_abnormal_muscle_cell2.48704182
22MP0004147_increased_porphyrin_level2.46630597
23MP0009278_abnormal_bone_marrow2.44372477
24MP0005076_abnormal_cell_differentiation2.44344001
25MP0000749_muscle_degeneration2.39541935
26MP0010329_abnormal_lipoprotein_level2.26818055
27MP0005670_abnormal_white_adipose2.22587042
28MP0008438_abnormal_cutaneous_collagen2.03519377
29MP0004087_abnormal_muscle_fiber2.00136403
30MP0005666_abnormal_adipose_tissue1.97061585
31MP0004859_abnormal_synaptic_plasticity1.90027185
32MP0002972_abnormal_cardiac_muscle1.88041186
33MP0002118_abnormal_lipid_homeostasis1.86280273
34MP0002269_muscular_atrophy1.86212036
35MP0005083_abnormal_biliary_tract1.85802103
36MP0003137_abnormal_impulse_conducting1.84232028
37MP0000678_abnormal_parathyroid_gland1.83838536
38MP0001849_ear_inflammation1.80684964
39MP0008775_abnormal_heart_ventricle1.80393410
40MP0003656_abnormal_erythrocyte_physiolo1.80096471
41MP0003453_abnormal_keratinocyte_physiol1.78252910
42MP0003279_aneurysm1.77580769
43MP0003191_abnormal_cellular_cholesterol1.76608764
44MP0003221_abnormal_cardiomyocyte_apopto1.76392244
45MP0005584_abnormal_enzyme/coenzyme_acti1.76283415
46MP0004043_abnormal_pH_regulation1.71299782
47MP0009333_abnormal_splenocyte_physiolog1.67488895
48MP0003436_decreased_susceptibility_to1.64147257
49MP0001958_emphysema1.62459641
50MP0005620_abnormal_muscle_contractility1.60817400
51MP0004947_skin_inflammation1.59644262
52MP0001544_abnormal_cardiovascular_syste1.59035469
53MP0005385_cardiovascular_system_phenoty1.59035469
54MP0001661_extended_life_span1.58774431
55MP0010630_abnormal_cardiac_muscle1.56528116
56MP0000747_muscle_weakness1.55454787
57MP0005266_abnormal_metabolism1.53291358
58MP0002971_abnormal_brown_adipose1.44097769
59MP0003763_abnormal_thymus_physiology1.43600255
60MP0005501_abnormal_skin_physiology1.42811618
61MP0003186_abnormal_redox_activity1.40661765
62MP0005171_absent_coat_pigmentation1.40269296
63MP0005319_abnormal_enzyme/_coenzyme1.40003388
64MP0005451_abnormal_body_composition1.37037710
65MP0002106_abnormal_muscle_physiology1.36659757
66MP0006138_congestive_heart_failure1.36381665
67MP0001666_abnormal_nutrient_absorption1.34680433
68MP0005257_abnormal_intraocular_pressure1.33474321
69MP0004510_myositis1.32855217
70MP0006035_abnormal_mitochondrial_morpho1.31258331
71MP0002249_abnormal_larynx_morphology1.30794856
72MP0005375_adipose_tissue_phenotype1.28789029
73MP0001764_abnormal_homeostasis1.27807629
74MP0009643_abnormal_urine_homeostasis1.25122715
75MP0004085_abnormal_heartbeat1.24793780
76MP0000681_abnormal_thyroid_gland1.24587306
77MP0000609_abnormal_liver_physiology1.23685832
78MP0002933_joint_inflammation1.23588157
79MP0001968_abnormal_touch/_nociception1.21731457
80MP0000462_abnormal_digestive_system1.20986931
81MP0003091_abnormal_cell_migration1.18864070
82MP0000759_abnormal_skeletal_muscle1.18265072
83MP0003252_abnormal_bile_duct1.17902064
84MP0004233_abnormal_muscle_weight1.14656263
85MP0003195_calcinosis1.14401321
86MP0002796_impaired_skin_barrier1.13377130
87MP0003329_amyloid_beta_deposits1.13265948
88MP0005535_abnormal_body_temperature1.12565626
89MP0000858_altered_metastatic_potential1.12469150
90MP0009931_abnormal_skin_appearance1.12204970
91MP0005310_abnormal_salivary_gland1.11841314
92MP0001873_stomach_inflammation1.11558357
93MP0002078_abnormal_glucose_homeostasis1.10714855
94MP0004185_abnormal_adipocyte_glucose1.09218090
95MP0005409_darkened_coat_color1.08843619
96MP0000750_abnormal_muscle_regeneration1.06602123
97MP0002089_abnormal_postnatal_growth/wei1.06209943
98MP0002396_abnormal_hematopoietic_system1.05586027
99MP0009384_cardiac_valve_regurgitation1.04999367
100MP0005397_hematopoietic_system_phenotyp1.02521732
101MP0001545_abnormal_hematopoietic_system1.02521732
102MP0005369_muscle_phenotype1.02383877
103MP0001529_abnormal_vocalization1.01968380
104MP0003879_abnormal_hair_cell1.00783959
105MP0002332_abnormal_exercise_endurance1.00150333
106MP0003634_abnormal_glial_cell0.97334464
107MP0002970_abnormal_white_adipose0.95234301
108MP0002735_abnormal_chemical_nociception0.92909807
109MP0010771_integument_phenotype0.92185351
110MP0002736_abnormal_nociception_after0.91748759
111MP0005376_homeostasis/metabolism_phenot0.90391934
112MP0005623_abnormal_meninges_morphology0.88705696
113MP0000003_abnormal_adipose_tissue0.87621734
114MP0002877_abnormal_melanocyte_morpholog0.87591005
115MP0003959_abnormal_lean_body0.87467957
116MP0004270_analgesia0.87141617
117MP0008874_decreased_physiological_sensi0.85689630
118MP0000015_abnormal_ear_pigmentation0.85648842
119MP0001502_abnormal_circadian_rhythm0.85628033
120MP0004484_altered_response_of0.85249890
121MP0005621_abnormal_cell_physiology0.84307741
122MP0000230_abnormal_systemic_arterial0.83640132
123MP0001216_abnormal_epidermal_layer0.81852884
124MP0003566_abnormal_cell_adhesion0.81712401
125MP0005334_abnormal_fat_pad0.81524666
126MP0002127_abnormal_cardiovascular_syste0.80377103
127MP0003111_abnormal_nucleus_morphology0.80000167
128MP0000920_abnormal_myelination0.79622294
129MP0003690_abnormal_glial_cell0.79166582
130MP0003950_abnormal_plasma_membrane0.77402129
131MP0000358_abnormal_cell_content/0.77277333
132MP0004381_abnormal_hair_follicle0.76681879
133MP0004145_abnormal_muscle_electrophysio0.76609981
134MP0002098_abnormal_vibrissa_morphology0.75889358
135MP0003303_peritoneal_inflammation0.75839183
136MP0005448_abnormal_energy_balance0.75361831
137MP0000733_abnormal_muscle_development0.74746225
138MP0003283_abnormal_digestive_organ0.74588997
139MP0005636_abnormal_mineral_homeostasis0.74328672
140MP0005452_abnormal_adipose_tissue0.71994492
141MP0002822_catalepsy0.71951089
142MP0002060_abnormal_skin_morphology0.70499638
143MP0002909_abnormal_adrenal_gland0.70190044
144MP0005058_abnormal_lysosome_morphology0.69470882
145MP0009697_abnormal_copulation0.69334122
146MP0010368_abnormal_lymphatic_system0.68390020
147MP0008872_abnormal_physiological_respon0.66581994
148MP0000767_abnormal_smooth_muscle0.66084231
149MP0000598_abnormal_liver_morphology0.65770629
150MP0001243_abnormal_dermal_layer0.64736371
151MP0009115_abnormal_fat_cell0.63648928
152MP0001348_abnormal_lacrimal_gland0.63392892
153MP0005023_abnormal_wound_healing0.63050458
154MP0000604_amyloidosis0.62855006
155MP0001730_embryonic_growth_arrest0.61976775
156MP0009642_abnormal_blood_homeostasis0.61804192
157MP0004742_abnormal_vestibular_system0.58878497
158MP0005384_cellular_phenotype0.58421052
159MP0003075_altered_response_to0.57653046
160MP0000685_abnormal_immune_system0.57038561
161MP0003011_delayed_dark_adaptation0.56316494
162MP0000266_abnormal_heart_morphology0.56188840
163MP0005165_increased_susceptibility_to0.56008747
164MP0000367_abnormal_coat/_hair0.55629680
165MP0004019_abnormal_vitamin_homeostasis0.55458125
166MP0001756_abnormal_urination0.54689239
167MP0000013_abnormal_adipose_tissue0.53553429
168MP0003868_abnormal_feces_composition0.51721345
169MP0003953_abnormal_hormone_level0.51253400

Predicted human phenotypes

RankGene SetZ-score
1Myoglobinuria (HP:0002913)4.73719032
2Hepatic necrosis (HP:0002605)4.69013011
3Abnormality of fatty-acid metabolism (HP:0004359)4.48355257
4Dicarboxylic aciduria (HP:0003215)4.29374986
5Abnormality of dicarboxylic acid metabolism (HP:0010995)4.29374986
6Hypoglycemic coma (HP:0001325)4.29312733
7Hepatocellular necrosis (HP:0001404)4.17530277
8Ketosis (HP:0001946)4.16949546
9Hyperammonemia (HP:0001987)4.05952285
10Hyperglycinuria (HP:0003108)4.03187870
11Increased muscle lipid content (HP:0009058)4.03084011
12Ketoacidosis (HP:0001993)4.01128086
13Abnormality of glycine metabolism (HP:0010895)3.84130607
14Abnormality of serine family amino acid metabolism (HP:0010894)3.84130607
15Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.80471495
16Acute encephalopathy (HP:0006846)3.78013423
17Abnormal mitochondria in muscle tissue (HP:0008316)3.75511867
18Sudden death (HP:0001699)3.75478347
19Rhabdomyolysis (HP:0003201)3.74300843
20Exercise-induced muscle cramps (HP:0003710)3.69924028
21Increased serum pyruvate (HP:0003542)3.63221251
22Abnormality of glycolysis (HP:0004366)3.63221251
23Hyperacusis (HP:0010780)3.61802650
24Cerebral edema (HP:0002181)3.60931104
25Exercise-induced myalgia (HP:0003738)3.55273368
26Broad face (HP:0000283)3.53973634
27Acute necrotizing encephalopathy (HP:0006965)3.51731362
28Increased intramyocellular lipid droplets (HP:0012240)3.48467944
29Ragged-red muscle fibers (HP:0003200)3.44753298
30Increased CSF lactate (HP:0002490)3.43754618
31Mitochondrial inheritance (HP:0001427)3.43164158
32Ulnar bowing (HP:0003031)3.36242411
33Vertebral compression fractures (HP:0002953)3.29658721
34Abnormality of aromatic amino acid family metabolism (HP:0004338)3.27747392
35Distal upper limb amyotrophy (HP:0007149)3.26874679
36Upper limb amyotrophy (HP:0009129)3.26874679
37Thin bony cortex (HP:0002753)3.21581320
38Lactic acidosis (HP:0003128)3.20223389
39Testicular atrophy (HP:0000029)3.18171614
40J-shaped sella turcica (HP:0002680)3.17254018
41Palpitations (HP:0001962)3.16023167
42Lipid accumulation in hepatocytes (HP:0006561)3.10644185
43Lethargy (HP:0001254)3.08877942
44Ventricular tachycardia (HP:0004756)3.07512115
45Generalized aminoaciduria (HP:0002909)3.00939778
46Increased cerebral lipofuscin (HP:0011813)3.00869365
47Abnormality of liposaccharide metabolism (HP:0010968)2.98558505
48Abnormality of glycosphingolipid metabolism (HP:0004343)2.98558505
49Abnormality of glycolipid metabolism (HP:0010969)2.98558505
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.93582923
51Abnormality of polysaccharide metabolism (HP:0011012)2.93582923
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.93582923
53Xanthomatosis (HP:0000991)2.92338593
54Stridor (HP:0010307)2.91216660
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.88917333
56Hyperglycinemia (HP:0002154)2.87660494
57Calf muscle hypertrophy (HP:0008981)2.81564942
58Respiratory failure (HP:0002878)2.77565111
59Methylmalonic aciduria (HP:0012120)2.77121042
60Dysostosis multiplex (HP:0000943)2.75891550
61Progressive macrocephaly (HP:0004481)2.75885327
62Cervical subluxation (HP:0003308)2.74469781
63Hyperlipoproteinemia (HP:0010980)2.73551367
64Metabolic acidosis (HP:0001942)2.73523708
65Muscle hypertrophy of the lower extremities (HP:0008968)2.72104496
66Reticulocytosis (HP:0001923)2.72003376
67Cerebral aneurysm (HP:0004944)2.69676971
68Hand muscle atrophy (HP:0009130)2.68956110
69Dilated cardiomyopathy (HP:0001644)2.66702335
70Obstructive sleep apnea (HP:0002870)2.66628138
71Increased serum lactate (HP:0002151)2.65805537
72Lipoatrophy (HP:0100578)2.65139076
73Urinary glycosaminoglycan excretion (HP:0003541)2.65119649
74Mucopolysacchariduria (HP:0008155)2.65119649
75CNS demyelination (HP:0007305)2.63251212
76Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.61591462
77Protrusio acetabuli (HP:0003179)2.61558717
78Exercise intolerance (HP:0003546)2.61282720
79Myopathic facies (HP:0002058)2.59593755
80Delayed CNS myelination (HP:0002188)2.59556678
81Muscle fiber splitting (HP:0003555)2.58793775
82Neuroendocrine neoplasm (HP:0100634)2.57006466
83Increased hepatocellular lipid droplets (HP:0006565)2.56144630
84Cholelithiasis (HP:0001081)2.55505522
85Annular pancreas (HP:0001734)2.53510834
86Glycosuria (HP:0003076)2.53346099
87Abnormality of urine glucose concentration (HP:0011016)2.53346099
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.52950485
89Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.52950485
90Mesangial abnormality (HP:0001966)2.50175450
91Vomiting (HP:0002013)2.49869869
92Proximal tubulopathy (HP:0000114)2.45751871
93Atrial fibrillation (HP:0005110)2.44973006
94Gout (HP:0001997)2.44844622
95Insomnia (HP:0100785)2.43729528
96Intrahepatic cholestasis (HP:0001406)2.41916558
97Pheochromocytoma (HP:0002666)2.41513181
98Supraventricular tachycardia (HP:0004755)2.39284584
99Progressive muscle weakness (HP:0003323)2.38107340
100Biconcave vertebral bodies (HP:0004586)2.36502537
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36426809
102Truncus arteriosus (HP:0001660)2.36321531
103Abnormal gallbladder morphology (HP:0012437)2.35861879
104Atrioventricular block (HP:0001678)2.35285452
105Primary atrial arrhythmia (HP:0001692)2.35063459
106Methylmalonic acidemia (HP:0002912)2.34240412
107Joint stiffness (HP:0001387)2.32446115
108Supraventricular arrhythmia (HP:0005115)2.31731373
109Deep venous thrombosis (HP:0002625)2.31278651
110Centrally nucleated skeletal muscle fibers (HP:0003687)2.29065723
111Nausea (HP:0002018)2.28535835
112Nonimmune hydrops fetalis (HP:0001790)2.27080432
113Hypobetalipoproteinemia (HP:0003563)2.25319156
114Osteolytic defects of the phalanges of the hand (HP:0009771)2.24909909
115Osteolytic defects of the hand bones (HP:0009699)2.24909909
116Conjunctival hamartoma (HP:0100780)2.23522491
117Natal tooth (HP:0000695)2.22615064
118Premature rupture of membranes (HP:0001788)2.21963837
119Distal lower limb amyotrophy (HP:0008944)2.21932904
120Emotional lability (HP:0000712)2.21510694
121Ventricular arrhythmia (HP:0004308)2.19358567
122Ankle clonus (HP:0011448)2.18669064
123Neuronal loss in central nervous system (HP:0002529)2.18545688
124Hemorrhage of the eye (HP:0011885)2.18071303
125Cholecystitis (HP:0001082)2.17974147
126Abnormal gallbladder physiology (HP:0012438)2.17974147
127Supranuclear gaze palsy (HP:0000605)2.17080757
128Long palpebral fissure (HP:0000637)2.14465729
129Abnormality of serum amino acid levels (HP:0003112)2.13958184
130Turricephaly (HP:0000262)2.13915150
131Brushfield spots (HP:0001088)2.13214083
132Leukodystrophy (HP:0002415)2.12688789
133Hyperinsulinemic hypoglycemia (HP:0000825)2.09967546
134Achilles tendon contracture (HP:0001771)2.09471862
135Asymmetric septal hypertrophy (HP:0001670)2.06746934
136Wormian bones (HP:0002645)2.06246148
137Prolonged QT interval (HP:0001657)2.05440425
138Hypolipoproteinemia (HP:0010981)2.04444008
139Abnormality of the calf musculature (HP:0001430)2.04100087
140Syncope (HP:0001279)2.03895373
141Hyporeflexia of lower limbs (HP:0002600)2.03302037
142Subaortic stenosis (HP:0001682)2.03250273
143Abnormality of the left ventricular outflow tract (HP:0011103)2.03250273
144Late onset (HP:0003584)2.02405040
145Renal Fanconi syndrome (HP:0001994)2.02296514
146Muscle stiffness (HP:0003552)2.02072099
147Heart block (HP:0012722)2.02016227
148Distal lower limb muscle weakness (HP:0009053)2.00991785
149Difficulty running (HP:0009046)2.00666397
150Spastic paraparesis (HP:0002313)1.99604673
151Hypoglycemic seizures (HP:0002173)1.99500793
152Gastrointestinal dysmotility (HP:0002579)1.99476948
153Broad distal phalanx of finger (HP:0009836)1.99339991
154Loss of speech (HP:0002371)1.95721601
155Colitis (HP:0002583)1.95267045
156Shallow orbits (HP:0000586)1.95139516
157Pointed chin (HP:0000307)1.94078406
158Slow saccadic eye movements (HP:0000514)1.93241977
159Difficulty climbing stairs (HP:0003551)1.92600703
160Abnormality of the gallbladder (HP:0005264)1.91982414
161Easy fatigability (HP:0003388)1.90767043
162Increased connective tissue (HP:0009025)1.90494054
163Bowel incontinence (HP:0002607)1.90415834
164Advanced eruption of teeth (HP:0006288)1.89636891
165Poikiloderma (HP:0001029)1.88805740
166Abnormal cortical bone morphology (HP:0003103)1.88580643
167Dysmetric saccades (HP:0000641)1.87854110
168Atelectasis (HP:0100750)1.87047197
169Microvesicular hepatic steatosis (HP:0001414)1.86152858
170Cerebral inclusion bodies (HP:0100314)1.85378267
171Amblyopia (HP:0000646)1.83487740
172Disproportionate tall stature (HP:0001519)1.82685717
173Hypertriglyceridemia (HP:0002155)1.81529792
174Mitral regurgitation (HP:0001653)1.80225566
175Thin ribs (HP:0000883)1.79724931
176Neurofibrillary tangles (HP:0002185)1.79354577
177Abnormality of the Achilles tendon (HP:0005109)1.79343124
178Genu recurvatum (HP:0002816)1.78436508
179Abnormal large intestine physiology (HP:0012700)1.78373586
180Fragile skin (HP:0001030)1.76841449
181Hyperparathyroidism (HP:0000843)1.76134429
182Hypertensive crisis (HP:0100735)1.76071575
183Abnormality of the aortic arch (HP:0012303)1.75700350
184Visual hallucinations (HP:0002367)1.74161804
185Bulbar palsy (HP:0001283)1.71518709
186Autoamputation (HP:0001218)1.71018660
187Bladder diverticulum (HP:0000015)1.68810590
188Abnormality of the thoracic spine (HP:0100711)1.68554956
189Axonal loss (HP:0003447)1.68387726
190Peripheral hypomyelination (HP:0007182)1.68215519
191Spinal rigidity (HP:0003306)1.68096398
192Generalized amyotrophy (HP:0003700)1.67625758
193Elbow flexion contracture (HP:0002987)1.66543968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.12583452
2SMG14.11142737
3LMTK24.09380362
4TRIB33.87064341
5PDK33.46511503
6PDK43.46511503
7PKN23.03504597
8PHKG12.92609281
9PHKG22.92609281
10PRPF4B2.85758442
11TTN2.50637877
12NEK12.46050928
13WNK42.43772870
14OBSCN2.41530044
15STK392.38722622
16IRAK32.23267671
17BRSK21.95675033
18CDK121.83670170
19BRSK11.76372722
20MYLK1.74923623
21MUSK1.72184413
22PINK11.69294837
23EPHB11.69189254
24TESK11.58310895
25ARAF1.58291359
26PRKD21.53778931
27ICK1.52538279
28SIK21.52181878
29SIK11.51645340
30MAP3K111.37319812
31MARK21.36616475
32PRKD31.36342455
33OXSR11.32190818
34PDK21.29940295
35ILK1.18353608
36TAOK21.14526916
37TAOK11.06844041
38MAP3K71.06241413
39CDK41.05663778
40NME11.04832175
41EPHA21.03705646
42FLT31.02776946
43CAMKK10.99800576
44VRK20.99100764
45BMX0.97166328
46MTOR0.95723504
47MAP3K100.94468001
48TNK20.92486981
49TIE10.89767820
50RPS6KA20.89557546
51CAMK1D0.89388107
52LRRK20.85774523
53KDR0.85541885
54MST1R0.84949973
55CDK190.84023127
56MET0.83382785
57CDC42BPA0.82828993
58BUB10.82742726
59PRKD10.82095573
60MAPK110.81527155
61TBK10.79259240
62BRAF0.79193342
63WNK10.78742528
64RIPK10.76891066
65PRKAA20.76203723
66PIM20.76150349
67PTK20.75868042
68PDPK10.75206572
69PBK0.75175053
70CAMK2D0.73862631
71PIK3CA0.73578611
72PAK40.72561928
73RAF10.70854908
74DMPK0.69969424
75PRKAA10.68990256
76AURKA0.68872670
77NME20.68531170
78PTK60.68049255
79EEF2K0.68038778
80TYK20.66795637
81CAMK2G0.66258881
82WEE10.65877720
83JAK30.62807333
84GRK60.62270798
85MAPKAPK30.62174948
86MAP4K10.62049053
87DAPK30.61031520
88MAPK120.60860775
89PAK30.58446836
90PDK10.57671440
91MAP2K20.57260442
92TYRO30.55393837
93ZAP700.51393175
94KSR20.51077124
95ERN10.50952233
96MAP3K130.50515979
97MAP2K30.50509159
98STK380.49134888
99NEK90.48987731
100CAMK40.48606052
101NTRK10.48518077
102WNK30.48477755
103PRKACG0.47777862
104STK240.46882489
105ABL20.46879751
106PRKACB0.46283612
107MAP3K30.45905673
108MAPK150.45633689
109PAK60.45595211
110MAP3K10.45392431
111PKN10.45367475
112SGK4940.45036199
113SGK2230.45036199
114MAP3K80.44830345
115CDK80.43229403
116RPS6KA60.43130610
117PDGFRA0.41012546
118TESK20.39808591
119DAPK10.39789210
120PAK10.39080857
121CAMK10.38463090
122RIPK40.37607262
123HIPK20.37472014
124AKT20.37414151
125PRKG20.37168206
126RPS6KC10.36700017
127RPS6KL10.36700017
128MAP3K60.35850526
129FES0.35464237
130ROCK20.35402381
131PIK3CG0.35246378
132MAPKAPK50.35240208
133MAP2K10.34645359
134CSNK1A1L0.34267631
135MAPK40.34207519
136LIMK10.34097240
137TTK0.34029704
138RPS6KA10.33712428
139PRKACA0.32305300
140UHMK10.32097194
141FGFR40.31281355
142MAP2K60.30121875
143CCNB10.29658191
144BLK0.29329107
145EPHA40.29254718
146RET0.29166429
147PRKCH0.28633585
148CAMK1G0.28571391
149PRKCQ0.27765092
150RPS6KB20.26787904
151CSNK1G30.26786220
152JAK20.25561841
153CAMK2B0.25173806

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.21784743
2Other glycan degradation_Homo sapiens_hsa005113.74789032
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61555423
4Propanoate metabolism_Homo sapiens_hsa006403.59869062
5Fatty acid degradation_Homo sapiens_hsa000713.40291811
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.26466074
7Glycosaminoglycan degradation_Homo sapiens_hsa005313.21331583
8Fatty acid metabolism_Homo sapiens_hsa012122.90042378
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.85126388
10Butanoate metabolism_Homo sapiens_hsa006502.50621647
11Carbon metabolism_Homo sapiens_hsa012002.48980376
12Nitrogen metabolism_Homo sapiens_hsa009102.43747502
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.42079849
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40034879
15Pyruvate metabolism_Homo sapiens_hsa006202.35378285
16Fatty acid elongation_Homo sapiens_hsa000622.32695937
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.24549843
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.14452690
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13217446
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.04457288
21Parkinsons disease_Homo sapiens_hsa050121.99871678
22Oxidative phosphorylation_Homo sapiens_hsa001901.98236078
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.95571536
24Arginine biosynthesis_Homo sapiens_hsa002201.93312360
25PPAR signaling pathway_Homo sapiens_hsa033201.89520106
26Lysosome_Homo sapiens_hsa041421.86555280
27Biosynthesis of amino acids_Homo sapiens_hsa012301.81381523
28Tryptophan metabolism_Homo sapiens_hsa003801.79906774
29Peroxisome_Homo sapiens_hsa041461.79737352
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.75692815
31Acute myeloid leukemia_Homo sapiens_hsa052211.70955285
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.69233746
33VEGF signaling pathway_Homo sapiens_hsa043701.65038643
34beta-Alanine metabolism_Homo sapiens_hsa004101.60770509
35Cardiac muscle contraction_Homo sapiens_hsa042601.51241171
36Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.48573800
37mTOR signaling pathway_Homo sapiens_hsa041501.46245499
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45523699
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44770222
40Prion diseases_Homo sapiens_hsa050201.39647462
41Chronic myeloid leukemia_Homo sapiens_hsa052201.38866194
42Notch signaling pathway_Homo sapiens_hsa043301.34228791
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33528274
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.31146445
45Alzheimers disease_Homo sapiens_hsa050101.31073619
46Starch and sucrose metabolism_Homo sapiens_hsa005001.28076290
47Fatty acid biosynthesis_Homo sapiens_hsa000611.28056396
48Bladder cancer_Homo sapiens_hsa052191.26813650
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24861886
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23492955
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22837133
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.22409678
53Inositol phosphate metabolism_Homo sapiens_hsa005621.12580238
54Synaptic vesicle cycle_Homo sapiens_hsa047211.12194265
55Huntingtons disease_Homo sapiens_hsa050161.09512910
56Arginine and proline metabolism_Homo sapiens_hsa003301.08716085
57Pentose phosphate pathway_Homo sapiens_hsa000301.07771227
58Vibrio cholerae infection_Homo sapiens_hsa051101.06670589
59Folate biosynthesis_Homo sapiens_hsa007901.06648601
60Longevity regulating pathway - mammal_Homo sapiens_hsa042111.06279268
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.05424368
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03225611
63N-Glycan biosynthesis_Homo sapiens_hsa005101.02782409
64Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02093434
65Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01499543
66Drug metabolism - other enzymes_Homo sapiens_hsa009831.00362874
67Non-small cell lung cancer_Homo sapiens_hsa052231.00082246
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.99509938
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.97480339
70Sulfur metabolism_Homo sapiens_hsa009200.95675180
71Sulfur relay system_Homo sapiens_hsa041220.93273051
72Fat digestion and absorption_Homo sapiens_hsa049750.92613442
73Vitamin B6 metabolism_Homo sapiens_hsa007500.92470671
74Endocytosis_Homo sapiens_hsa041440.90090715
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88137911
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87389372
77Pancreatic cancer_Homo sapiens_hsa052120.86884009
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86051408
79ErbB signaling pathway_Homo sapiens_hsa040120.85336817
80Histidine metabolism_Homo sapiens_hsa003400.85273227
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84479666
82Bile secretion_Homo sapiens_hsa049760.84043125
83Chemical carcinogenesis_Homo sapiens_hsa052040.83458306
84Glycerolipid metabolism_Homo sapiens_hsa005610.80675102
85Glutathione metabolism_Homo sapiens_hsa004800.79718448
86Phenylalanine metabolism_Homo sapiens_hsa003600.77266768
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.76554534
88Fructose and mannose metabolism_Homo sapiens_hsa000510.75431116
89Metabolic pathways_Homo sapiens_hsa011000.75366476
90Lysine degradation_Homo sapiens_hsa003100.74931899
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.74343159
92B cell receptor signaling pathway_Homo sapiens_hsa046620.73828373
93Galactose metabolism_Homo sapiens_hsa000520.73589209
94Apoptosis_Homo sapiens_hsa042100.72832550
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72740198
96Tyrosine metabolism_Homo sapiens_hsa003500.71778830
97Selenocompound metabolism_Homo sapiens_hsa004500.71005846
98Regulation of autophagy_Homo sapiens_hsa041400.69845900
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68964654
100GnRH signaling pathway_Homo sapiens_hsa049120.68929660
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67673268
102Glioma_Homo sapiens_hsa052140.67487095
103Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.66719163
104Shigellosis_Homo sapiens_hsa051310.66692431
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.62775518
106Caffeine metabolism_Homo sapiens_hsa002320.62460503
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.62059529
108Dilated cardiomyopathy_Homo sapiens_hsa054140.60835327
109* ABC transporters_Homo sapiens_hsa020100.60537342
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.60171119
111Type II diabetes mellitus_Homo sapiens_hsa049300.59675247
112Hepatitis C_Homo sapiens_hsa051600.59453177
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58928427
114Osteoclast differentiation_Homo sapiens_hsa043800.57797586
115Retinol metabolism_Homo sapiens_hsa008300.57501429
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56969075
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56218700
118Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54279751
119Endometrial cancer_Homo sapiens_hsa052130.53785302
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52483873
121Glucagon signaling pathway_Homo sapiens_hsa049220.51447934
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51440952
123Toxoplasmosis_Homo sapiens_hsa051450.50980534
124One carbon pool by folate_Homo sapiens_hsa006700.50808384
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.50776703
126Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50492324
127Sphingolipid metabolism_Homo sapiens_hsa006000.48171659
128Tuberculosis_Homo sapiens_hsa051520.46081205
129HTLV-I infection_Homo sapiens_hsa051660.45539227
130Hepatitis B_Homo sapiens_hsa051610.45106988
131Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44118928
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.43375879
133TNF signaling pathway_Homo sapiens_hsa046680.43064653
134Estrogen signaling pathway_Homo sapiens_hsa049150.41444845
135Focal adhesion_Homo sapiens_hsa045100.39888437
136Steroid biosynthesis_Homo sapiens_hsa001000.39781354
137Long-term potentiation_Homo sapiens_hsa047200.39372021
138HIF-1 signaling pathway_Homo sapiens_hsa040660.38920133
139Complement and coagulation cascades_Homo sapiens_hsa046100.38282597
140Small cell lung cancer_Homo sapiens_hsa052220.37128791
141Salmonella infection_Homo sapiens_hsa051320.36930943
142Choline metabolism in cancer_Homo sapiens_hsa052310.36623485
143AMPK signaling pathway_Homo sapiens_hsa041520.35982847
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34875884
145Renal cell carcinoma_Homo sapiens_hsa052110.34525203
146Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34434534
147MAPK signaling pathway_Homo sapiens_hsa040100.33369470
148Insulin signaling pathway_Homo sapiens_hsa049100.32320728
149Insulin resistance_Homo sapiens_hsa049310.31392799
150alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27423124
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25006845
152Vitamin digestion and absorption_Homo sapiens_hsa049770.24615469
153Central carbon metabolism in cancer_Homo sapiens_hsa052300.19673281
154Glycerophospholipid metabolism_Homo sapiens_hsa005640.18019571
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15703232
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.13880509
157Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.13588951
158Linoleic acid metabolism_Homo sapiens_hsa005910.12665429
159Ribosome_Homo sapiens_hsa030100.11102849
160DNA replication_Homo sapiens_hsa030300.09197686
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.06206089
162Purine metabolism_Homo sapiens_hsa002300.04733149
163Pyrimidine metabolism_Homo sapiens_hsa002400.03877949
164Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.03219906
165Base excision repair_Homo sapiens_hsa03410-0.0481246
166Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0378140
167Proteasome_Homo sapiens_hsa03050-0.0126137

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »