ABCB9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This family member functions in the translocation of peptides from the cytosol into the lysosomal lumen. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specificities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)4.86809913
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.63232467
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.48472461
4neuronal action potential propagation (GO:0019227)4.41614287
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.38244571
6synaptic vesicle maturation (GO:0016188)4.36915158
7locomotory exploration behavior (GO:0035641)4.32520878
8DNA deamination (GO:0045006)4.28023395
9response to pheromone (GO:0019236)4.10237803
10vocalization behavior (GO:0071625)3.95179697
11regulation of synaptic vesicle exocytosis (GO:2000300)3.92613541
12synaptic vesicle exocytosis (GO:0016079)3.90774224
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.85365239
14L-fucose catabolic process (GO:0042355)3.78793642
15fucose catabolic process (GO:0019317)3.78793642
16L-fucose metabolic process (GO:0042354)3.78793642
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68570107
18neuron cell-cell adhesion (GO:0007158)3.67669834
19protein polyglutamylation (GO:0018095)3.66295448
20positive regulation of synaptic transmission, GABAergic (GO:0032230)3.65006738
21regulation of synaptic vesicle transport (GO:1902803)3.63251693
22regulation of glutamate receptor signaling pathway (GO:1900449)3.58595469
23detection of calcium ion (GO:0005513)3.57923373
24protein localization to synapse (GO:0035418)3.55288795
25ionotropic glutamate receptor signaling pathway (GO:0035235)3.52871096
26glutamate secretion (GO:0014047)3.49966888
27regulation of neuronal synaptic plasticity (GO:0048168)3.49431221
28neurotransmitter secretion (GO:0007269)3.44847039
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.41164314
30glycine transport (GO:0015816)3.39720892
31piRNA metabolic process (GO:0034587)3.35779930
32detection of light stimulus involved in sensory perception (GO:0050962)3.35524717
33detection of light stimulus involved in visual perception (GO:0050908)3.35524717
34kynurenine metabolic process (GO:0070189)3.35405523
35pyrimidine nucleobase catabolic process (GO:0006208)3.35288755
36regulation of synapse structural plasticity (GO:0051823)3.34600212
37indole-containing compound catabolic process (GO:0042436)3.32980601
38indolalkylamine catabolic process (GO:0046218)3.32980601
39tryptophan catabolic process (GO:0006569)3.32980601
40synaptic transmission, glutamatergic (GO:0035249)3.29127125
41retinal cone cell development (GO:0046549)3.24364051
42positive regulation of membrane potential (GO:0045838)3.23917739
43detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.22817787
44indolalkylamine metabolic process (GO:0006586)3.22316257
45regulation of vesicle fusion (GO:0031338)3.21709227
46synaptic vesicle docking involved in exocytosis (GO:0016081)3.21428134
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.20716798
48transmission of nerve impulse (GO:0019226)3.18329222
49long-term memory (GO:0007616)3.17535453
50activation of protein kinase A activity (GO:0034199)3.17426392
51glutamate receptor signaling pathway (GO:0007215)3.16865842
52neuron-neuron synaptic transmission (GO:0007270)3.13919866
53dendritic spine morphogenesis (GO:0060997)3.13716314
54neurotransmitter-gated ion channel clustering (GO:0072578)3.12998946
55exploration behavior (GO:0035640)3.11598046
56cellular ketone body metabolic process (GO:0046950)3.10764985
57protein-cofactor linkage (GO:0018065)3.09743645
58cellular potassium ion homeostasis (GO:0030007)3.06761842
59auditory behavior (GO:0031223)3.06323131
60negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06173549
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.06133316
62calcium ion-dependent exocytosis (GO:0017156)3.05008983
63protein localization to cilium (GO:0061512)3.04996702
64behavioral response to ethanol (GO:0048149)3.04776597
65neuronal action potential (GO:0019228)3.02598032
66neuronal ion channel clustering (GO:0045161)3.02299526
67regulation of hippo signaling (GO:0035330)3.01864955
68membrane depolarization during action potential (GO:0086010)2.99356678
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97286184
70primary amino compound metabolic process (GO:1901160)2.97137163
71response to auditory stimulus (GO:0010996)2.96459580
72regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.92905635
73preassembly of GPI anchor in ER membrane (GO:0016254)2.92840646
74auditory receptor cell stereocilium organization (GO:0060088)2.91767877
75DNA methylation involved in gamete generation (GO:0043046)2.91562176
76cellular response to interleukin-15 (GO:0071350)2.90860767
77water-soluble vitamin biosynthetic process (GO:0042364)2.90492509
78cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89713260
79neurotransmitter transport (GO:0006836)2.88903636
80protein complex biogenesis (GO:0070271)2.88882772
81tryptophan metabolic process (GO:0006568)2.87802958
82regulation of excitatory postsynaptic membrane potential (GO:0060079)2.86763651
83cAMP catabolic process (GO:0006198)2.84574508
84cyclic nucleotide catabolic process (GO:0009214)2.83472137
85ketone body metabolic process (GO:1902224)2.82570545
86nucleobase catabolic process (GO:0046113)2.82436056
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.82158950
88mitochondrial respiratory chain complex I assembly (GO:0032981)2.82158950
89NADH dehydrogenase complex assembly (GO:0010257)2.82158950
90chemosensory behavior (GO:0007635)2.81402042
91postsynaptic membrane organization (GO:0001941)2.79668660
92cerebellar Purkinje cell differentiation (GO:0021702)2.78823751
93striatum development (GO:0021756)2.78623035
94proline transport (GO:0015824)2.78611802
95regulation of synaptic transmission, GABAergic (GO:0032228)2.76586441
96membrane hyperpolarization (GO:0060081)2.75758194
97serotonin metabolic process (GO:0042428)2.75287623
98protein K11-linked deubiquitination (GO:0035871)2.75063468
99regulation of isotype switching to IgG isotypes (GO:0048302)2.74911476
100indole-containing compound metabolic process (GO:0042430)2.74854359
101mechanosensory behavior (GO:0007638)2.74790363
102negative regulation of telomere maintenance (GO:0032205)2.74159413
103gamma-aminobutyric acid transport (GO:0015812)2.73923205
104glycosphingolipid biosynthetic process (GO:0006688)2.72769950
105regulation of synaptic plasticity (GO:0048167)2.72722507
106regulation of synaptic transmission, glutamatergic (GO:0051966)2.70337273
107axoneme assembly (GO:0035082)2.70222070
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.70019012
109regulation of postsynaptic membrane potential (GO:0060078)2.69999087
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69352367
111regulation of glycogen (starch) synthase activity (GO:2000465)2.68922555
112glycerophospholipid catabolic process (GO:0046475)2.68055031
113prepulse inhibition (GO:0060134)2.67960832
114positive regulation of neurotransmitter transport (GO:0051590)2.67259061
115multicellular organism reproduction (GO:0032504)2.66675529
116L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.66108675
117membrane depolarization (GO:0051899)2.65845910
118long-term synaptic potentiation (GO:0060291)2.65431220
119startle response (GO:0001964)2.65239859
120cornea development in camera-type eye (GO:0061303)2.64881632
121regulation of neurotransmitter secretion (GO:0046928)2.64576648
122adenosine receptor signaling pathway (GO:0001973)2.64053224
123layer formation in cerebral cortex (GO:0021819)2.63939084
124pseudouridine synthesis (GO:0001522)2.63311809
125cell communication by electrical coupling (GO:0010644)2.62845189
126sulfation (GO:0051923)2.62732026
127positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.62351505
128mitochondrial respiratory chain complex assembly (GO:0033108)2.62158026
129mannosylation (GO:0097502)2.62127267
130cellular response to ATP (GO:0071318)2.60865792
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60759177
132regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60555619
133C4-dicarboxylate transport (GO:0015740)2.58064764
134regulation of ARF protein signal transduction (GO:0032012)2.57102314
135rhodopsin mediated signaling pathway (GO:0016056)2.56900466
136phosphorelay signal transduction system (GO:0000160)2.56337892
137adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.56095283
138regulation of action potential (GO:0098900)2.55744858
139regulation of neurotransmitter levels (GO:0001505)2.55555606
140presynaptic membrane assembly (GO:0097105)2.55264671
141respiratory chain complex IV assembly (GO:0008535)2.53143546
142positive regulation of potassium ion transport (GO:0043268)2.52997052
143potassium ion import (GO:0010107)2.52974856
144positive regulation of potassium ion transmembrane transport (GO:1901381)2.52460429
145regulation of voltage-gated calcium channel activity (GO:1901385)2.52456533
146insulin secretion (GO:0030073)2.51854707
147sodium ion export (GO:0071436)2.51795982
148neuromuscular process controlling posture (GO:0050884)2.51617896
149positive regulation of fatty acid transport (GO:2000193)2.51439434
150positive regulation of neurotransmitter secretion (GO:0001956)2.50972548
151regulation of neurotransmitter transport (GO:0051588)2.50808781
152regulation of neurotransmitter uptake (GO:0051580)2.49673969
153dendritic spine organization (GO:0097061)2.49454721
154adaptation of signaling pathway (GO:0023058)2.49341972
155negative regulation of cell cycle arrest (GO:0071157)2.49149328
156replication fork processing (GO:0031297)2.48379180
157behavioral response to cocaine (GO:0048148)2.47602422
158regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.46811597
159neuromuscular synaptic transmission (GO:0007274)2.46745135
160dopamine receptor signaling pathway (GO:0007212)2.45827115
161reciprocal meiotic recombination (GO:0007131)2.45760203
162reciprocal DNA recombination (GO:0035825)2.45760203
163G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.45713782
164reflex (GO:0060004)2.45602590
165nonmotile primary cilium assembly (GO:0035058)2.45574549
166response to interleukin-15 (GO:0070672)2.45273714
167ubiquinone biosynthetic process (GO:0006744)2.44124298
168cellular biogenic amine catabolic process (GO:0042402)2.43460618
169amine catabolic process (GO:0009310)2.43460618
170inner ear receptor stereocilium organization (GO:0060122)2.42422861
171meiotic chromosome segregation (GO:0045132)2.41794445
172platelet dense granule organization (GO:0060155)2.41640235
173opioid receptor signaling pathway (GO:0038003)2.38773805
174cytochrome complex assembly (GO:0017004)2.38456899
175epithelial cilium movement (GO:0003351)2.35073886
176response to misfolded protein (GO:0051788)2.33928662
177ubiquinone metabolic process (GO:0006743)2.33253750
178negative regulation of Rho protein signal transduction (GO:0035024)2.32030615
179synaptic transmission, cholinergic (GO:0007271)2.29670388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53240251
2GBX2_23144817_ChIP-Seq_PC3_Human3.06223679
3REST_21632747_ChIP-Seq_MESCs_Mouse2.68727869
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.67130612
5DROSHA_22980978_ChIP-Seq_HELA_Human2.59222892
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55394484
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51004458
8* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39131107
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32818189
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.26683971
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25067841
12* RARB_27405468_Chip-Seq_BRAIN_Mouse2.24499122
13IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22922477
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.20725966
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19113133
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.18715541
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.14999959
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.14684307
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12955383
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12955383
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11849714
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.05708529
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04737826
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.00258323
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.94777174
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87258945
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.84317253
28TP53_22573176_ChIP-Seq_HFKS_Human1.74086843
29FUS_26573619_Chip-Seq_HEK293_Human1.73040168
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.70687620
31EWS_26573619_Chip-Seq_HEK293_Human1.70609319
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69249110
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.68838766
34ER_23166858_ChIP-Seq_MCF-7_Human1.66724472
35AR_21572438_ChIP-Seq_LNCaP_Human1.63619515
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.61688452
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61051788
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58809181
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.51832240
40IRF1_19129219_ChIP-ChIP_H3396_Human1.49290708
41SMAD4_21799915_ChIP-Seq_A2780_Human1.47736324
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.47000136
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46355327
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44132992
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44118174
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41678991
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38439231
48SMAD_19615063_ChIP-ChIP_OVARY_Human1.38003253
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37972433
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37279527
51ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35826845
52BCAT_22108803_ChIP-Seq_LS180_Human1.35623360
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32850556
54CBP_20019798_ChIP-Seq_JUKART_Human1.32850556
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31030530
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29455630
57MYC_18940864_ChIP-ChIP_HL60_Human1.27026664
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26570473
59RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23318813
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23272505
61TAF15_26573619_Chip-Seq_HEK293_Human1.22644279
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.22229682
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21623397
64ERA_21632823_ChIP-Seq_H3396_Human1.21320298
65JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20774685
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18350177
67STAT3_23295773_ChIP-Seq_U87_Human1.17143762
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16975074
69OCT4_20526341_ChIP-Seq_ESCs_Human1.15184559
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.15184534
71NCOR_22424771_ChIP-Seq_293T_Human1.14843018
72VDR_22108803_ChIP-Seq_LS180_Human1.14526202
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13122530
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.13122530
75MYC_19829295_ChIP-Seq_ESCs_Human1.12855242
76ETS1_20019798_ChIP-Seq_JURKAT_Human1.12636796
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11627544
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.11455577
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10823101
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.09984465
81AR_20517297_ChIP-Seq_VCAP_Human1.09171079
82IGF1R_20145208_ChIP-Seq_DFB_Human1.08799990
83HOXB7_26014856_ChIP-Seq_BT474_Human1.08697378
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07525540
85FLI1_27457419_Chip-Seq_LIVER_Mouse1.07383605
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07316883
87* TCF4_23295773_ChIP-Seq_U87_Human1.06670416
88TCF4_22108803_ChIP-Seq_LS180_Human1.06018665
89NANOG_19829295_ChIP-Seq_ESCs_Human1.05962013
90SOX2_19829295_ChIP-Seq_ESCs_Human1.05962013
91P300_19829295_ChIP-Seq_ESCs_Human1.05848407
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.05121279
93MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04426626
94SMAD3_21741376_ChIP-Seq_EPCs_Human1.04160477
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03966566
96AR_25329375_ChIP-Seq_VCAP_Human1.02803939
97AR_19668381_ChIP-Seq_PC3_Human1.02427748
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02320315
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01740288
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.01720012
101GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01574001
102RNF2_27304074_Chip-Seq_NSC_Mouse1.01500917
103TAF2_19829295_ChIP-Seq_ESCs_Human1.01108576
104RING1B_27294783_Chip-Seq_ESCs_Mouse1.00896185
105SOX2_21211035_ChIP-Seq_LN229_Gbm1.00403776
106DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00165545
107MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99742812
108* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99522096
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98298893
110KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.98284859
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98281880
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97957864
113STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97885115
114FLI1_21867929_ChIP-Seq_TH2_Mouse0.97344499
115VDR_23849224_ChIP-Seq_CD4+_Human0.96972314
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.96710779
117PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96659715
118EST1_17652178_ChIP-ChIP_JURKAT_Human0.96621791
119NANOG_20526341_ChIP-Seq_ESCs_Human0.96289712
120PIAS1_25552417_ChIP-Seq_VCAP_Human0.94997988
121SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94642831
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94312165
123WDR5_24793694_ChIP-Seq_LNCAP_Human0.92057583
124CTCF_27219007_Chip-Seq_Bcells_Human0.91702181
125ZNF274_21170338_ChIP-Seq_K562_Hela0.91681038
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91656848
127P53_22387025_ChIP-Seq_ESCs_Mouse0.91470806
128CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90437287
129* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90138394
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89906348
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89495194
132* RUNX2_22187159_ChIP-Seq_PCA_Human0.88013883
133* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87758601
134NMYC_18555785_Chip-Seq_ESCs_Mouse0.87553441
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.87527581
136KDM2B_26808549_Chip-Seq_REH_Human0.87387512
137E2F1_18555785_Chip-Seq_ESCs_Mouse0.87245636
138* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.86818107
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86233181
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86233181
141STAT3_18555785_Chip-Seq_ESCs_Mouse0.86041603
142CMYC_18555785_Chip-Seq_ESCs_Mouse0.85403772
143ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85391539
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85136370
145NFE2_27457419_Chip-Seq_LIVER_Mouse0.84929057
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84606301
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.83849331
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83687317
149OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83602856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.70360206
2MP0002822_catalepsy3.56725310
3MP0003880_abnormal_central_pattern3.49202400
4MP0003635_abnormal_synaptic_transmissio3.37344342
5MP0004270_analgesia3.15298720
6MP0009745_abnormal_behavioral_response2.92876944
7MP0005423_abnormal_somatic_nervous2.63648011
8MP0002909_abnormal_adrenal_gland2.62795188
9MP0002063_abnormal_learning/memory/cond2.60814298
10MP0000569_abnormal_digit_pigmentation2.57637797
11MP0005646_abnormal_pituitary_gland2.45962914
12MP0002064_seizures2.44795543
13MP0001968_abnormal_touch/_nociception2.44413085
14MP0008877_abnormal_DNA_methylation2.41477638
15MP0009046_muscle_twitch2.40099203
16MP0002272_abnormal_nervous_system2.39452990
17MP0001486_abnormal_startle_reflex2.37014155
18MP0002572_abnormal_emotion/affect_behav2.35584256
19MP0002734_abnormal_mechanical_nocicepti2.28391015
20MP0002735_abnormal_chemical_nociception2.23120127
21MP0009780_abnormal_chondrocyte_physiolo2.20494213
22MP0001501_abnormal_sleep_pattern1.97250406
23MP0005645_abnormal_hypothalamus_physiol1.97176255
24MP0002736_abnormal_nociception_after1.94505401
25MP0001188_hyperpigmentation1.93323647
26MP0002733_abnormal_thermal_nociception1.92333947
27MP0002102_abnormal_ear_morphology1.91011568
28MP0001502_abnormal_circadian_rhythm1.90970169
29MP0001970_abnormal_pain_threshold1.88593993
30MP0008569_lethality_at_weaning1.87643156
31MP0005379_endocrine/exocrine_gland_phen1.82055489
32MP0008875_abnormal_xenobiotic_pharmacok1.80501511
33MP0002067_abnormal_sensory_capabilities1.71570643
34MP0006276_abnormal_autonomic_nervous1.67705443
35MP0002557_abnormal_social/conspecific_i1.66405515
36MP0001984_abnormal_olfaction1.66100997
37MP0002837_dystrophic_cardiac_calcinosis1.60502094
38MP0003787_abnormal_imprinting1.60153166
39MP0000427_abnormal_hair_cycle1.58296875
40MP0001529_abnormal_vocalization1.57254435
41MP0000013_abnormal_adipose_tissue1.56224982
42MP0005253_abnormal_eye_physiology1.53813459
43MP0002693_abnormal_pancreas_physiology1.52358232
44MP0003195_calcinosis1.52212531
45MP0004924_abnormal_behavior1.52060808
46MP0005386_behavior/neurological_phenoty1.52060808
47MP0002653_abnormal_ependyma_morphology1.51975784
48MP0005410_abnormal_fertilization1.51462772
49MP0003879_abnormal_hair_cell1.50130871
50MP0010386_abnormal_urinary_bladder1.49249407
51MP0001986_abnormal_taste_sensitivity1.46929514
52MP0002160_abnormal_reproductive_system1.46237560
53MP0005174_abnormal_tail_pigmentation1.45958792
54MP0003136_yellow_coat_color1.45345825
55MP0004043_abnormal_pH_regulation1.42159368
56MP0001440_abnormal_grooming_behavior1.41112901
57MP0002184_abnormal_innervation1.39839098
58MP0003283_abnormal_digestive_organ1.37004836
59MP0003329_amyloid_beta_deposits1.34364034
60MP0003121_genomic_imprinting1.32424959
61MP0005409_darkened_coat_color1.32174232
62MP0003183_abnormal_peptide_metabolism1.31362295
63MP0002638_abnormal_pupillary_reflex1.30470539
64MP0004811_abnormal_neuron_physiology1.29403096
65MP0003633_abnormal_nervous_system1.29231040
66MP0001905_abnormal_dopamine_level1.26216865
67MP0000955_abnormal_spinal_cord1.23473426
68MP0000372_irregular_coat_pigmentation1.21929924
69MP0003763_abnormal_thymus_physiology1.20934189
70MP0005310_abnormal_salivary_gland1.18954505
71MP0005389_reproductive_system_phenotype1.18292344
72MP0004133_heterotaxia1.14680406
73MP0002066_abnormal_motor_capabilities/c1.14360790
74MP0004142_abnormal_muscle_tone1.12464817
75MP0006072_abnormal_retinal_apoptosis1.12419278
76MP0002882_abnormal_neuron_morphology1.09633711
77MP0004742_abnormal_vestibular_system1.09393462
78MP0004145_abnormal_muscle_electrophysio1.07878806
79MP0005535_abnormal_body_temperature1.07409583
80MP0002938_white_spotting1.07097540
81MP0004510_myositis1.03426260
82MP0003122_maternal_imprinting1.03103807
83MP0002752_abnormal_somatic_nervous1.02573174
84MP0002229_neurodegeneration1.02034847
85MP0001919_abnormal_reproductive_system1.01533697
86MP0005671_abnormal_response_to1.01061018
87MP0008789_abnormal_olfactory_epithelium1.00929303
88MP0001765_abnormal_ion_homeostasis1.00683243
89MP0005377_hearing/vestibular/ear_phenot1.00618735
90MP0003878_abnormal_ear_physiology1.00618735
91MP0003698_abnormal_male_reproductive0.99495298
92MP0000631_abnormal_neuroendocrine_gland0.98038629
93MP0008961_abnormal_basal_metabolism0.97427631
94MP0003646_muscle_fatigue0.97255268
95MP0000015_abnormal_ear_pigmentation0.96909677
96MP0000678_abnormal_parathyroid_gland0.95208844
97MP0001944_abnormal_pancreas_morphology0.93898088
98MP0005394_taste/olfaction_phenotype0.93052806
99MP0005499_abnormal_olfactory_system0.93052806
100MP0005075_abnormal_melanosome_morpholog0.92704969
101MP0003631_nervous_system_phenotype0.92633708
102MP0002069_abnormal_eating/drinking_beha0.92113256
103MP0005195_abnormal_posterior_eye0.91437594
104MP0005551_abnormal_eye_electrophysiolog0.91375689
105MP0002928_abnormal_bile_duct0.89198650
106MP0001485_abnormal_pinna_reflex0.88022189
107MP0000026_abnormal_inner_ear0.87860755
108MP0008775_abnormal_heart_ventricle0.87476764
109MP0004858_abnormal_nervous_system0.87457140
110MP0000778_abnormal_nervous_system0.87210512
111MP0002876_abnormal_thyroid_physiology0.86904649
112MP0006035_abnormal_mitochondrial_morpho0.85326858
113MP0006292_abnormal_olfactory_placode0.84465698
114MP0004885_abnormal_endolymph0.84004269
115MP0002210_abnormal_sex_determination0.83288701
116MP0001929_abnormal_gametogenesis0.82582139
117MP0000920_abnormal_myelination0.80368073
118MP0003718_maternal_effect0.79282462
119MP0008058_abnormal_DNA_repair0.78954463
120MP0003123_paternal_imprinting0.78914005
121MP0004085_abnormal_heartbeat0.77283015
122MP0000230_abnormal_systemic_arterial0.77280352
123MP0001664_abnormal_digestion0.76944817
124MP0003866_abnormal_defecation0.76643586
125MP0002078_abnormal_glucose_homeostasis0.76380122
126MP0008872_abnormal_physiological_respon0.73724711
127MP0004147_increased_porphyrin_level0.71929759
128MP0008874_decreased_physiological_sensi0.71773596
129MP0003172_abnormal_lysosome_physiology0.71327282
130MP0003045_fibrosis0.70646582
131MP0003953_abnormal_hormone_level0.69239929
132MP0002234_abnormal_pharynx_morphology0.69133273
133MP0001963_abnormal_hearing_physiology0.67693070
134MP0002163_abnormal_gland_morphology0.66820935
135MP0002152_abnormal_brain_morphology0.65035109
136MP0003137_abnormal_impulse_conducting0.63173172
137MP0005448_abnormal_energy_balance0.62914881

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.78811355
2Myokymia (HP:0002411)4.97910699
3Visual hallucinations (HP:0002367)4.31696752
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.30717712
5Febrile seizures (HP:0002373)4.18493285
6Congenital stationary night blindness (HP:0007642)4.17465442
7Pancreatic cysts (HP:0001737)3.98858320
8Type II lissencephaly (HP:0007260)3.93168138
9Pancreatic fibrosis (HP:0100732)3.88849884
10Focal seizures (HP:0007359)3.85294522
11Abnormality of midbrain morphology (HP:0002418)3.81181306
12Molar tooth sign on MRI (HP:0002419)3.81181306
13Epileptic encephalopathy (HP:0200134)3.76212938
14Absent/shortened dynein arms (HP:0200106)3.60699208
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.60699208
16Abnormality of calcium-phosphate metabolism (HP:0100530)3.46622790
17Attenuation of retinal blood vessels (HP:0007843)3.44945751
18True hermaphroditism (HP:0010459)3.38709990
19Atonic seizures (HP:0010819)3.36153711
20Ankle clonus (HP:0011448)3.32945522
21Nephronophthisis (HP:0000090)3.30093491
22Retinal dysplasia (HP:0007973)3.08067591
23Progressive cerebellar ataxia (HP:0002073)3.05812874
24Anxiety (HP:0000739)3.00227527
25Abnormality of the renal medulla (HP:0100957)2.98183934
26Cerebellar dysplasia (HP:0007033)2.95391407
27Generalized tonic-clonic seizures (HP:0002069)2.94208191
28Supranuclear gaze palsy (HP:0000605)2.90594261
29Bundle branch block (HP:0011710)2.90095671
30Lissencephaly (HP:0001339)2.85104282
31Chronic hepatic failure (HP:0100626)2.84451245
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81606871
33Abnormality of alanine metabolism (HP:0010916)2.81606871
34Hyperalaninemia (HP:0003348)2.81606871
35Abnormality of the renal cortex (HP:0011035)2.74892820
36Absence seizures (HP:0002121)2.72104791
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71366733
38Depression (HP:0000716)2.69507162
39Diplopia (HP:0000651)2.66629039
40Abnormality of binocular vision (HP:0011514)2.66629039
41Abolished electroretinogram (ERG) (HP:0000550)2.66461374
42Agitation (HP:0000713)2.65428564
43Spastic gait (HP:0002064)2.64144028
44Cystic liver disease (HP:0006706)2.62537956
45Pendular nystagmus (HP:0012043)2.61289977
46Gaze-evoked nystagmus (HP:0000640)2.55013669
47Decreased circulating renin level (HP:0003351)2.52084095
48Polydipsia (HP:0001959)2.51769910
49Abnormal rod and cone electroretinograms (HP:0008323)2.49893202
50Abnormal respiratory motile cilium physiology (HP:0012261)2.49740896
51Hyperparathyroidism (HP:0000843)2.49518736
52Abnormal ciliary motility (HP:0012262)2.49459034
53Urinary bladder sphincter dysfunction (HP:0002839)2.48734522
54Ventricular fibrillation (HP:0001663)2.48283245
55Hyperinsulinemic hypoglycemia (HP:0000825)2.48156661
56Abnormal eating behavior (HP:0100738)2.47664208
57Aplasia/Hypoplasia of the tibia (HP:0005772)2.46803654
58Chorioretinal atrophy (HP:0000533)2.42048596
59Dialeptic seizures (HP:0011146)2.39764388
60Action tremor (HP:0002345)2.39686170
61Postural instability (HP:0002172)2.39657771
62Impaired vibration sensation in the lower limbs (HP:0002166)2.39313825
63Pachygyria (HP:0001302)2.38846071
64Prolonged QT interval (HP:0001657)2.37568267
65Protruding tongue (HP:0010808)2.37388424
66Papilledema (HP:0001085)2.37099560
67Progressive inability to walk (HP:0002505)2.36703819
68Severe muscular hypotonia (HP:0006829)2.35183919
69Pheochromocytoma (HP:0002666)2.33939095
70Poor eye contact (HP:0000817)2.33101447
71Sclerocornea (HP:0000647)2.31568387
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.30887266
73Abnormal respiratory epithelium morphology (HP:0012253)2.30615324
74Abnormal respiratory motile cilium morphology (HP:0005938)2.30615324
75Truncal ataxia (HP:0002078)2.30339134
76Genetic anticipation (HP:0003743)2.27415081
77Tubular atrophy (HP:0000092)2.27342111
78Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27101363
79Abnormal EKG (HP:0003115)2.25728811
80Dysmetria (HP:0001310)2.25669791
81Megalencephaly (HP:0001355)2.25339204
82Symptomatic seizures (HP:0011145)2.23601996
83Bony spicule pigmentary retinopathy (HP:0007737)2.23345127
84Hemiparesis (HP:0001269)2.22490460
85Hypoglycemic seizures (HP:0002173)2.21213852
86Patellar aplasia (HP:0006443)2.20667581
87EEG with generalized epileptiform discharges (HP:0011198)2.20192530
88Epileptiform EEG discharges (HP:0011182)2.19477174
89Aplasia/Hypoplasia of the tongue (HP:0010295)2.18448632
90Decreased central vision (HP:0007663)2.16892100
91Clumsiness (HP:0002312)2.16668814
92Aplasia/Hypoplasia of the patella (HP:0006498)2.16653041
93Hypoplasia of the pons (HP:0012110)2.15576939
94Increased corneal curvature (HP:0100692)2.13742207
95Keratoconus (HP:0000563)2.13742207
96Hemiplegia (HP:0002301)2.13341143
97Urinary urgency (HP:0000012)2.12400912
98Progressive microcephaly (HP:0000253)2.12112356
99Hypsarrhythmia (HP:0002521)2.11046171
100Neuroendocrine neoplasm (HP:0100634)2.10762304
101Insulin-resistant diabetes mellitus (HP:0000831)2.09848115
102Absent rod-and cone-mediated responses on ERG (HP:0007688)2.09680118
103Spinal canal stenosis (HP:0003416)2.06118950
104Broad-based gait (HP:0002136)2.05946112
105Neurofibrillary tangles (HP:0002185)2.04364644
106Abnormality of the pons (HP:0007361)2.01612444
107Polyuria (HP:0000103)2.01553553
108Impaired social interactions (HP:0000735)2.00951389
109Abnormal social behavior (HP:0012433)2.00951389
110Lower limb muscle weakness (HP:0007340)2.00073921
111Scanning speech (HP:0002168)1.99372673
112Congenital hepatic fibrosis (HP:0002612)1.98776174
113Stereotypic behavior (HP:0000733)1.97594562
114Heart block (HP:0012722)1.96356335
115Concave nail (HP:0001598)1.95197327
116Renal cortical cysts (HP:0000803)1.94249914
117Congenital primary aphakia (HP:0007707)1.94109029
118Increased CSF lactate (HP:0002490)1.93506691
119Mitochondrial inheritance (HP:0001427)1.93326726
120Postaxial foot polydactyly (HP:0001830)1.91435712
121Large for gestational age (HP:0001520)1.91177408
122Short tibia (HP:0005736)1.91038164
123Dysdiadochokinesis (HP:0002075)1.90475037
124Ketosis (HP:0001946)1.90454088
125Impaired smooth pursuit (HP:0007772)1.89011620
126Hepatocellular necrosis (HP:0001404)1.88851738
127Insomnia (HP:0100785)1.87809680
1283-Methylglutaconic aciduria (HP:0003535)1.86621080
129Nephrogenic diabetes insipidus (HP:0009806)1.85979845
130Polymicrogyria (HP:0002126)1.85635435
131Genital tract atresia (HP:0001827)1.85226549
132Bile duct proliferation (HP:0001408)1.84245452
133Abnormal biliary tract physiology (HP:0012439)1.84245452
134Absent speech (HP:0001344)1.83887246
135Fair hair (HP:0002286)1.82920327
136Lower limb amyotrophy (HP:0007210)1.82277186
137Hypercortisolism (HP:0001578)1.82057642
138Anencephaly (HP:0002323)1.81642632
139Medial flaring of the eyebrow (HP:0010747)1.81578295
140Syncope (HP:0001279)1.81321588
141Male pseudohermaphroditism (HP:0000037)1.80663983
142Menstrual irregularities (HP:0000858)1.80569508
143Optic nerve hypoplasia (HP:0000609)1.80239984
144Occipital encephalocele (HP:0002085)1.79641760
145Clonus (HP:0002169)1.79497677
146Polyphagia (HP:0002591)1.79203370
147Amelogenesis imperfecta (HP:0000705)1.78857580
148Small hand (HP:0200055)1.78731293
149Hyperphosphatemia (HP:0002905)1.78499670
150Ketoacidosis (HP:0001993)1.77956878
151Status epilepticus (HP:0002133)1.77223566
152Acute necrotizing encephalopathy (HP:0006965)1.76909466
153Cortical visual impairment (HP:0100704)1.76443605
154Psychosis (HP:0000709)1.76442885
155Abnormality of renin-angiotensin system (HP:0000847)1.75203055
156Panhypogammaglobulinemia (HP:0003139)1.75119706
157Abnormality of magnesium homeostasis (HP:0004921)1.74489879
158Hepatic necrosis (HP:0002605)1.74365686
159Dyskinesia (HP:0100660)1.73736247
160Fetal akinesia sequence (HP:0001989)1.73189615
161Increased serum lactate (HP:0002151)1.73121648
162Limb dystonia (HP:0002451)1.72892162
163Bradykinesia (HP:0002067)1.71725541
164Inability to walk (HP:0002540)1.71194344
165Impaired vibratory sensation (HP:0002495)1.70863707
166Torticollis (HP:0000473)1.70826873
167Furrowed tongue (HP:0000221)1.70583626
168Iris hypopigmentation (HP:0007730)1.70038155
169Ocular albinism (HP:0001107)1.69730966
170Optic disc pallor (HP:0000543)1.69434998
171Hyperventilation (HP:0002883)1.69235247
172Unilateral renal agenesis (HP:0000122)1.68564214
173Drooling (HP:0002307)1.67436353
174Gait imbalance (HP:0002141)1.66808281
175Abnormal atrioventricular conduction (HP:0005150)1.65919256
176Amblyopia (HP:0000646)1.65152211
177T lymphocytopenia (HP:0005403)1.65055677
178Abnormal drinking behavior (HP:0030082)1.61213515

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.90317554
2NTRK34.26972492
3EPHA43.74914141
4MAP4K23.27122737
5MAP3K92.93355233
6ZAK2.86763695
7BMPR1B2.62983770
8TLK12.57629628
9PRKD32.57152080
10TXK2.48923460
11MAP2K72.26245541
12TNIK2.20179338
13MARK11.99341306
14CASK1.98275251
15MUSK1.78752485
16NTRK21.78237239
17INSRR1.74972144
18MINK11.74077301
19MAP3K41.72547721
20NUAK11.71953044
21WNK41.67470113
22CAMKK21.60351288
23PRKCH1.58072177
24CAMKK11.56106578
25MAP3K131.55337679
26ACVR1B1.54113395
27DAPK21.53331665
28OXSR11.49068214
29MAP3K121.45247316
30TNK21.42114421
31STK391.39379153
32NTRK11.38461456
33PAK61.37052356
34RIPK41.35484926
35MAPK131.35012682
36CSNK1G31.34398604
37PINK11.34336951
38CSNK1G21.32119694
39BCKDK1.31294530
40CDK51.30681076
41KSR21.25413775
42STK381.24734155
43SIK21.24297478
44SGK21.22838304
45TAOK31.22311470
46CSNK1A1L1.22235245
47SGK4941.21472214
48SGK2231.21472214
49LMTK21.20080847
50UHMK11.19582829
51BMPR21.19536618
52ADRBK11.17766055
53MAPKAPK31.13991795
54MAPK151.13851310
55CSNK1G11.13559836
56TRIM281.12625462
57IRAK31.11045651
58PHKG11.10344407
59PHKG21.10344407
60MAP3K21.08048613
61TAF11.07321745
62PRPF4B1.06581498
63FES1.06239048
64DYRK21.06224464
65CDC42BPA1.05660292
66NEK61.04116017
67HIPK21.01248124
68MAP3K10.99367400
69MARK20.98621049
70MAP2K60.96873797
71WNK10.96400331
72PRKCG0.95132029
73MAP4K10.94818967
74SGK30.91551649
75PRKD20.91138250
76IRAK20.86987444
77CAMK2A0.85833474
78IRAK10.85150663
79PLK20.84433340
80PRKCI0.82321737
81DAPK10.80389976
82PDK10.79572456
83LIMK10.77459932
84CAMK10.76511557
85RPS6KA50.75341491
86MAP3K70.74874986
87VRK10.74106345
88GRK50.73208451
89JAK10.72508755
90GRK10.72272691
91STK110.71871898
92ARAF0.71757105
93NME10.71358627
94ITK0.70659249
95TAOK10.69758429
96PKN10.69560331
97MAP2K40.69553902
98PRKCE0.68667823
99RET0.68443605
100PRKCQ0.68441761
101PAK30.67906122
102MAP3K110.67657148
103GRK70.66359884
104ADRBK20.63553525
105STK38L0.62400178
106SGK10.62145578
107PDPK10.60888357
108DMPK0.60679945
109FGFR20.60640539
110WNK30.60061763
111CAMK1G0.56248459
112PIM20.54955706
113CSNK1A10.53827681
114CAMK2B0.53817820
115CCNB10.52733890
116IKBKE0.52233869
117PTK2B0.51204906
118PASK0.50868398
119NLK0.50761635
120FYN0.50553185
121DYRK1A0.50266879
122PRKCZ0.49591505
123STK160.49252893
124FGFR30.47787591
125CDK190.47658082
126ZAP700.47434778
127BRAF0.46720797
128CSNK1D0.46583022
129PRKAA10.46288185
130KSR10.45855409
131CAMK1D0.44373870
132CAMK2G0.44271042
133MAPKAPK50.44178865
134SYK0.41453370
135IRAK40.39927201
136TIE10.39522578
137TYRO30.39304461
138PLK10.39142739
139ATR0.38965457
140CDK80.38310316
141PRKACA0.37956337
142VRK20.37657262
143PRKCA0.37303735
144RPS6KA30.36208171
145CAMK40.35729508
146BCR0.35384236
147CAMK2D0.34413317
148MKNK20.33804538
149IKBKB0.32250449
150MAP2K10.29772446
151FER0.29433867
152PNCK0.28175637

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.70366651
2Nicotine addiction_Homo sapiens_hsa050332.69168058
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68623280
4Insulin secretion_Homo sapiens_hsa049112.67832135
5Synaptic vesicle cycle_Homo sapiens_hsa047212.62134889
6Olfactory transduction_Homo sapiens_hsa047402.49779979
7Morphine addiction_Homo sapiens_hsa050322.40374602
8Circadian entrainment_Homo sapiens_hsa047132.28821310
9Amphetamine addiction_Homo sapiens_hsa050312.27085447
10RNA polymerase_Homo sapiens_hsa030202.26874307
11Long-term potentiation_Homo sapiens_hsa047202.22294570
12Glutamatergic synapse_Homo sapiens_hsa047242.21043057
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.12983606
14GABAergic synapse_Homo sapiens_hsa047272.11985416
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04003982
16Cocaine addiction_Homo sapiens_hsa050302.03597949
17Linoleic acid metabolism_Homo sapiens_hsa005912.02016986
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96669260
19Butanoate metabolism_Homo sapiens_hsa006501.96423838
20Taste transduction_Homo sapiens_hsa047421.90256219
21Cholinergic synapse_Homo sapiens_hsa047251.88660756
22Nitrogen metabolism_Homo sapiens_hsa009101.88006055
23Salivary secretion_Homo sapiens_hsa049701.85380506
24Dopaminergic synapse_Homo sapiens_hsa047281.83715404
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82893596
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.80998779
27Gastric acid secretion_Homo sapiens_hsa049711.78396537
28Oxidative phosphorylation_Homo sapiens_hsa001901.76826724
29Homologous recombination_Homo sapiens_hsa034401.74275985
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.73852379
31Type II diabetes mellitus_Homo sapiens_hsa049301.71491645
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.70274617
33Fanconi anemia pathway_Homo sapiens_hsa034601.67023327
34Serotonergic synapse_Homo sapiens_hsa047261.64227005
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63968760
36Selenocompound metabolism_Homo sapiens_hsa004501.62635953
37Renin secretion_Homo sapiens_hsa049241.57941436
38Caffeine metabolism_Homo sapiens_hsa002321.48249954
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47871533
40Basal transcription factors_Homo sapiens_hsa030221.46179043
41Tryptophan metabolism_Homo sapiens_hsa003801.44910683
42Type I diabetes mellitus_Homo sapiens_hsa049401.42545679
43Calcium signaling pathway_Homo sapiens_hsa040201.42186708
44Sulfur relay system_Homo sapiens_hsa041221.38233097
45Oxytocin signaling pathway_Homo sapiens_hsa049211.36982345
46cAMP signaling pathway_Homo sapiens_hsa040241.35932104
47Phosphatidylinositol signaling system_Homo sapiens_hsa040701.34000381
48Long-term depression_Homo sapiens_hsa047301.33791557
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.32621581
50Parkinsons disease_Homo sapiens_hsa050121.31170079
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.24534839
52Circadian rhythm_Homo sapiens_hsa047101.23867950
53Pancreatic secretion_Homo sapiens_hsa049721.23638830
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22258920
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21120314
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21087562
57Collecting duct acid secretion_Homo sapiens_hsa049661.21001970
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15153284
59* ABC transporters_Homo sapiens_hsa020101.13954231
60T cell receptor signaling pathway_Homo sapiens_hsa046601.12424095
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.12068815
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.11401255
63GnRH signaling pathway_Homo sapiens_hsa049121.10182192
64cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09271185
65Estrogen signaling pathway_Homo sapiens_hsa049151.01717017
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.00876175
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00536773
68Primary immunodeficiency_Homo sapiens_hsa053400.99844111
69Huntingtons disease_Homo sapiens_hsa050160.97390907
70RNA degradation_Homo sapiens_hsa030180.95840289
71Phototransduction_Homo sapiens_hsa047440.93548434
72Vibrio cholerae infection_Homo sapiens_hsa051100.92445907
73Gap junction_Homo sapiens_hsa045400.88403125
74Purine metabolism_Homo sapiens_hsa002300.88099928
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87985898
76Peroxisome_Homo sapiens_hsa041460.86298911
77Propanoate metabolism_Homo sapiens_hsa006400.86281483
78Dorso-ventral axis formation_Homo sapiens_hsa043200.86028226
79Cardiac muscle contraction_Homo sapiens_hsa042600.85676883
80Pyrimidine metabolism_Homo sapiens_hsa002400.84315340
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.82126618
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79350119
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.77794497
84Glycerolipid metabolism_Homo sapiens_hsa005610.74631190
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.72892725
86Melanogenesis_Homo sapiens_hsa049160.72759859
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72582332
88Glucagon signaling pathway_Homo sapiens_hsa049220.71961165
89Inositol phosphate metabolism_Homo sapiens_hsa005620.69407237
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69387728
91Chemokine signaling pathway_Homo sapiens_hsa040620.69005416
92ErbB signaling pathway_Homo sapiens_hsa040120.68954029
93Thyroid hormone synthesis_Homo sapiens_hsa049180.68697096
94Prolactin signaling pathway_Homo sapiens_hsa049170.68615350
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68609577
96Choline metabolism in cancer_Homo sapiens_hsa052310.67860619
97Fatty acid biosynthesis_Homo sapiens_hsa000610.67788236
98beta-Alanine metabolism_Homo sapiens_hsa004100.66966502
99Metabolic pathways_Homo sapiens_hsa011000.66562832
100Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66329623
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65943833
102MAPK signaling pathway_Homo sapiens_hsa040100.65917762
103One carbon pool by folate_Homo sapiens_hsa006700.65761522
104Glioma_Homo sapiens_hsa052140.64157818
105Regulation of autophagy_Homo sapiens_hsa041400.63314901
106Dilated cardiomyopathy_Homo sapiens_hsa054140.63112376
107Axon guidance_Homo sapiens_hsa043600.61643993
108Primary bile acid biosynthesis_Homo sapiens_hsa001200.61064123
109Graft-versus-host disease_Homo sapiens_hsa053320.58537655
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.58424992
111Arachidonic acid metabolism_Homo sapiens_hsa005900.58152699
112Lysine degradation_Homo sapiens_hsa003100.57471403
113VEGF signaling pathway_Homo sapiens_hsa043700.57293695
114Ovarian steroidogenesis_Homo sapiens_hsa049130.56831053
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56575259
116Sphingolipid metabolism_Homo sapiens_hsa006000.56197552
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.56187943
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53815315
119Insulin signaling pathway_Homo sapiens_hsa049100.53561949
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53501453
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51390604
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50849382
123Histidine metabolism_Homo sapiens_hsa003400.50800933
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50589717
125Ras signaling pathway_Homo sapiens_hsa040140.50297137
126Steroid biosynthesis_Homo sapiens_hsa001000.49569320
127Chemical carcinogenesis_Homo sapiens_hsa052040.48922203
128Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48718935
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47987822
130Allograft rejection_Homo sapiens_hsa053300.47164820
131Neurotrophin signaling pathway_Homo sapiens_hsa047220.46743595
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46031002
133Endocytosis_Homo sapiens_hsa041440.45892856
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45132295
135Alzheimers disease_Homo sapiens_hsa050100.42387444
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41858873
137Alcoholism_Homo sapiens_hsa050340.40748903
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40388541
139Rap1 signaling pathway_Homo sapiens_hsa040150.39747806
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39474388
141Ether lipid metabolism_Homo sapiens_hsa005650.38935180
142Rheumatoid arthritis_Homo sapiens_hsa053230.38768481
143Autoimmune thyroid disease_Homo sapiens_hsa053200.37500198
144Arginine and proline metabolism_Homo sapiens_hsa003300.35921375
145Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35181404
146Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34531199
147Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34423590
148Protein export_Homo sapiens_hsa030600.32600233
149Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30987921
150Fatty acid elongation_Homo sapiens_hsa000620.30766840
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.28076454
152N-Glycan biosynthesis_Homo sapiens_hsa005100.28068584

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