ABCC10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1replicative senescence (GO:0090399)6.20329223
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.74092263
3L-phenylalanine catabolic process (GO:0006559)4.74092263
4mannose metabolic process (GO:0006013)4.73740638
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.63001947
6L-phenylalanine metabolic process (GO:0006558)4.63001947
7intestinal cholesterol absorption (GO:0030299)4.57860034
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.56051296
9pyrimidine-containing compound transmembrane transport (GO:0072531)4.28550849
10behavioral response to nicotine (GO:0035095)4.20495130
11regulation of cholesterol homeostasis (GO:2000188)4.16803370
12positive regulation of CREB transcription factor activity (GO:0032793)4.09545888
13aromatic amino acid family catabolic process (GO:0009074)4.05176360
14tryptophan catabolic process (GO:0006569)3.81680978
15indole-containing compound catabolic process (GO:0042436)3.81680978
16indolalkylamine catabolic process (GO:0046218)3.81680978
17regulation of bile acid biosynthetic process (GO:0070857)3.72118440
18negative thymic T cell selection (GO:0045060)3.64872146
19tryptophan metabolic process (GO:0006568)3.54799451
20phosphatidylglycerol biosynthetic process (GO:0006655)3.52622934
21response to pheromone (GO:0019236)3.50699055
22biotin metabolic process (GO:0006768)3.50223348
23negative T cell selection (GO:0043383)3.46290781
24thymic T cell selection (GO:0045061)3.43849522
25kynurenine metabolic process (GO:0070189)3.41932007
26cellular response to exogenous dsRNA (GO:0071360)3.40802166
27high-density lipoprotein particle remodeling (GO:0034375)3.35558204
28urea metabolic process (GO:0019627)3.34527832
29urea cycle (GO:0000050)3.34527832
30phosphatidylethanolamine metabolic process (GO:0046337)3.32844721
31amino-acid betaine metabolic process (GO:0006577)3.30711399
32positive regulation of triglyceride lipase activity (GO:0061365)3.30508208
33positive regulation of lipoprotein lipase activity (GO:0051006)3.30508208
34intestinal absorption (GO:0050892)3.30322169
35phospholipid efflux (GO:0033700)3.29793697
36positive thymic T cell selection (GO:0045059)3.29285898
37nucleotide transmembrane transport (GO:1901679)3.28712114
38phosphatidylethanolamine biosynthetic process (GO:0006646)3.27421022
39sulfur amino acid catabolic process (GO:0000098)3.25305815
40alpha-linolenic acid metabolic process (GO:0036109)3.24984304
41positive regulation of defense response to virus by host (GO:0002230)3.23513102
42positive regulation of histone deacetylation (GO:0031065)3.21555189
43positive regulation of interleukin-8 secretion (GO:2000484)3.20951083
44cholesterol efflux (GO:0033344)3.20819301
45L-fucose catabolic process (GO:0042355)3.16660678
46fucose catabolic process (GO:0019317)3.16660678
47L-fucose metabolic process (GO:0042354)3.16660678
48triglyceride homeostasis (GO:0070328)3.16216187
49acylglycerol homeostasis (GO:0055090)3.16216187
50carnitine shuttle (GO:0006853)3.15701993
51triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.15600940
52positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15166928
53regulation of cholesterol esterification (GO:0010872)3.14502911
54purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.12516224
553-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.12516224
56regulation of hydrogen peroxide metabolic process (GO:0010310)3.12030591
57cellular biogenic amine catabolic process (GO:0042402)3.11434598
58amine catabolic process (GO:0009310)3.11434598
59negative regulation of cell killing (GO:0031342)3.09613450
60negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09613450
61hormone catabolic process (GO:0042447)3.04170565
62reverse cholesterol transport (GO:0043691)3.03846301
63fucosylation (GO:0036065)3.03539058
64bile acid biosynthetic process (GO:0006699)3.01255807
65activated T cell proliferation (GO:0050798)3.00734222
66T cell selection (GO:0045058)2.99010758
67positive regulation of protein kinase C signaling (GO:0090037)2.98184901
68tolerance induction (GO:0002507)2.97189137
69negative regulation of sterol transport (GO:0032372)2.94061206
70negative regulation of cholesterol transport (GO:0032375)2.94061206
71very-low-density lipoprotein particle assembly (GO:0034379)2.93586330
72positive regulation of cholesterol efflux (GO:0010875)2.92587640
73semaphorin-plexin signaling pathway (GO:0071526)2.92512750
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92225543
75phospholipid homeostasis (GO:0055091)2.91268992
76lipoprotein metabolic process (GO:0042157)2.91241810
77NAD biosynthetic process (GO:0009435)2.89770175
78positive T cell selection (GO:0043368)2.87945265
79positive regulation of gamma-delta T cell activation (GO:0046645)2.87339250
80indolalkylamine metabolic process (GO:0006586)2.86749064
81imidazole-containing compound metabolic process (GO:0052803)2.85446124
82plasma lipoprotein particle assembly (GO:0034377)2.85308683
83energy homeostasis (GO:0097009)2.85253667
84antigen processing and presentation via MHC class Ib (GO:0002475)2.84174291
85L-alpha-amino acid transmembrane transport (GO:1902475)2.82957261
86bile acid metabolic process (GO:0008206)2.82176116
87bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80615882
88fatty acid beta-oxidation (GO:0006635)2.79062277
89carnitine metabolic process (GO:0009437)2.78737781
90nitrogen cycle metabolic process (GO:0071941)2.78636210
91cellular response to ATP (GO:0071318)2.76912038
92regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.76852432
93positive regulation of triglyceride biosynthetic process (GO:0010867)2.76130039
94aromatic amino acid family metabolic process (GO:0009072)2.75816400
95negative regulation of cAMP-mediated signaling (GO:0043951)2.75623932
96fatty acid transmembrane transport (GO:1902001)2.75376803
97intracellular lipid transport (GO:0032365)2.74722523
98positive regulation of cholesterol transport (GO:0032376)2.72166075
99positive regulation of sterol transport (GO:0032373)2.72166075
100positive regulation of triglyceride metabolic process (GO:0090208)2.72033768
101plasma lipoprotein particle remodeling (GO:0034369)2.72014354
102protein-lipid complex remodeling (GO:0034368)2.72014354
103macromolecular complex remodeling (GO:0034367)2.72014354
104antigen processing and presentation of endogenous antigen (GO:0019883)2.71743257
105telomere maintenance via telomerase (GO:0007004)2.71248585
106fatty acid oxidation (GO:0019395)2.71241122
107regulation of triglyceride catabolic process (GO:0010896)2.70504906
108cellular anion homeostasis (GO:0030002)2.70163153
109serine family amino acid catabolic process (GO:0009071)2.69097739
110regulation of lipoprotein particle clearance (GO:0010984)2.69071479
111lipid oxidation (GO:0034440)2.68503172
112drug catabolic process (GO:0042737)2.68384631
113cholesterol homeostasis (GO:0042632)2.67675525
114histone H3-K4 trimethylation (GO:0080182)2.67256756
115ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.66948082
116macroautophagy (GO:0016236)2.64250761
117glyoxylate metabolic process (GO:0046487)2.63580788
118vitamin transmembrane transport (GO:0035461)2.59712555
119urinary tract smooth muscle contraction (GO:0014848)2.59266186
120sterol homeostasis (GO:0055092)2.59175151
121antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.58727987
122regulation of interleukin-8 secretion (GO:2000482)2.58576556
123DNA deamination (GO:0045006)2.57817873
124coenzyme catabolic process (GO:0009109)2.57768236
125poly(A)+ mRNA export from nucleus (GO:0016973)2.57526718
126cellular glucuronidation (GO:0052695)2.56351025
127regulation of triglyceride biosynthetic process (GO:0010866)2.55613917
128regulation of triglyceride metabolic process (GO:0090207)2.54916117
129linoleic acid metabolic process (GO:0043651)2.54426718
130positive regulation of cellular amide metabolic process (GO:0034250)2.53872006
131histone H3-K4 methylation (GO:0051568)2.52304202
132regulation of hippo signaling (GO:0035330)2.51565613
133alpha-amino acid catabolic process (GO:1901606)2.50757473
134purinergic nucleotide receptor signaling pathway (GO:0035590)2.50424312
135positive regulation of protein homooligomerization (GO:0032464)2.50358606
136interferon-gamma secretion (GO:0072643)2.50355749
137plasma lipoprotein particle organization (GO:0071827)2.50292049
138histone H4-K12 acetylation (GO:0043983)2.49552589
139homocysteine metabolic process (GO:0050667)2.48271266
1402-oxoglutarate metabolic process (GO:0006103)2.47439463
141regulation of synapse maturation (GO:0090128)2.45770646
142regulation of defense response to virus by host (GO:0050691)2.45706358
143regulation of histone deacetylation (GO:0031063)2.45536274
144positive regulation of T cell mediated cytotoxicity (GO:0001916)2.44755504
145regulation of hypersensitivity (GO:0002883)2.44565185
146negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43426842
147protein targeting to lysosome (GO:0006622)2.43007500
148establishment of protein localization to vacuole (GO:0072666)2.43007500
149protein targeting to vacuole (GO:0006623)2.43007500
150regulation of gamma-delta T cell differentiation (GO:0045586)2.41932790
151regulation of gamma-delta T cell activation (GO:0046643)2.41603374
152negative regulation of telomere maintenance (GO:0032205)2.38623251
153regulation of ARF GTPase activity (GO:0032312)2.35630407
154histone H3-K9 modification (GO:0061647)2.35148975
155regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.34577451
156cardiolipin metabolic process (GO:0032048)2.34556917
157N-glycan processing (GO:0006491)2.34078542
158positive regulation of protein deacetylation (GO:0090312)2.33428681
159negative regulation of Rho protein signal transduction (GO:0035024)2.33117660
160regulation of T cell mediated cytotoxicity (GO:0001914)2.30993374
161histone H3-K9 methylation (GO:0051567)2.29493005
162negative regulation of mast cell activation (GO:0033004)2.29298339
163lytic vacuole organization (GO:0080171)2.28898386
164lysosome organization (GO:0007040)2.28898386
165nephron epithelium morphogenesis (GO:0072088)2.26614867
166nephron tubule morphogenesis (GO:0072078)2.26614867
167cell migration in hindbrain (GO:0021535)2.23438620
168positive regulation of antigen processing and presentation (GO:0002579)2.20863633
169regulation of cilium assembly (GO:1902017)2.19277019
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.18475771
171hemidesmosome assembly (GO:0031581)2.18251136
172response to muramyl dipeptide (GO:0032495)2.17910971
173regulation of antigen processing and presentation (GO:0002577)2.16665220
174regulation of interleukin-12 biosynthetic process (GO:0045075)2.14319996
175N-acetylneuraminate metabolic process (GO:0006054)2.13921722
176positive regulation of Rab GTPase activity (GO:0032851)2.13080996
177regulation of Rab GTPase activity (GO:0032313)2.13080996
178regulation of dendritic cell antigen processing and presentation (GO:0002604)2.11837886
179negative regulation of T-helper cell differentiation (GO:0045623)2.11656871
180negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.11656871
181negative regulation of T cell mediated immunity (GO:0002710)2.10975191
182glycine transport (GO:0015816)2.10739786
183establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.10673665
184mitochondrion transport along microtubule (GO:0047497)2.10673665
185fucose metabolic process (GO:0006004)2.10247722
186antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.08576802
187positive regulation of calcium-mediated signaling (GO:0050850)2.08463439
188interferon-gamma production (GO:0032609)2.06629293
189opioid receptor signaling pathway (GO:0038003)2.06298845
190RNA destabilization (GO:0050779)2.04382321
191gamma-aminobutyric acid transport (GO:0015812)2.04063128
192negative regulation of macroautophagy (GO:0016242)2.03421002
193positive regulation of synapse maturation (GO:0090129)2.02834628
194negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.00300999
195basic amino acid transport (GO:0015802)1.99947112
196regulation of mast cell activation (GO:0033003)1.99734528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.77593482
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.48113864
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.41724247
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.09132131
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.52547816
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.32863591
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.19392150
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.11768488
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.01707799
10CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.87830913
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.70232133
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.61332268
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48158786
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.45268194
15DROSHA_22980978_ChIP-Seq_HELA_Human2.43351761
16VDR_21846776_ChIP-Seq_THP-1_Human2.21474552
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.19896956
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.16716651
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.02578303
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.00958504
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96544637
22BCL6_27268052_Chip-Seq_Bcells_Human1.95899321
23BCOR_27268052_Chip-Seq_Bcells_Human1.85237146
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.83754002
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79021354
26CDX2_20551321_ChIP-Seq_CACO-2_Human1.73035101
27ELF1_20517297_ChIP-Seq_JURKAT_Human1.69949928
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69696329
29* ELK3_25401928_ChIP-Seq_HUVEC_Human1.62911474
30KDM2B_26808549_Chip-Seq_DND41_Human1.62251354
31TP53_22127205_ChIP-Seq_IMR90_Human1.58292959
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57928813
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51987659
34MAF_26560356_Chip-Seq_TH2_Human1.51233248
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50497763
36EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48229676
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47817550
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45523933
39FOXA2_19822575_ChIP-Seq_HepG2_Human1.44312542
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.42525408
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.42517667
42RUNX_20019798_ChIP-Seq_JUKART_Human1.38230363
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.37609183
44ERA_21632823_ChIP-Seq_H3396_Human1.37107634
45EZH2_22144423_ChIP-Seq_EOC_Human1.36255379
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36055344
47DNAJC2_21179169_ChIP-ChIP_NT2_Human1.35369696
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33288842
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.33046017
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.32513594
51IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32390877
52MAF_26560356_Chip-Seq_TH1_Human1.32290320
53RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32161150
54UTX_26944678_Chip-Seq_JUKART_Human1.31898029
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31164822
56ZNF274_21170338_ChIP-Seq_K562_Hela1.29963290
57SUZ12_27294783_Chip-Seq_ESCs_Mouse1.28335698
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28221420
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27699462
60TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.27509783
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27407496
62CTCF_20526341_ChIP-Seq_ESCs_Human1.26798891
63OCT4_19829295_ChIP-Seq_ESCs_Human1.26721249
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26316654
65EZH2_27294783_Chip-Seq_ESCs_Mouse1.25772492
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.25572933
67STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23102663
68SA1_27219007_Chip-Seq_Bcells_Human1.22612896
69SCL_19346495_ChIP-Seq_HPC-7_Human1.22348652
70SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21928033
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.19188273
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.18885449
73RACK7_27058665_Chip-Seq_MCF-7_Human1.18151748
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18013506
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17918345
76* HNF4A_19822575_ChIP-Seq_HepG2_Human1.17625039
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15183520
78GATA2_21666600_ChIP-Seq_HMVEC_Human1.14669479
79P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14661817
80MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14406520
81CTCF_26484167_Chip-Seq_Bcells_Mouse1.14224661
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.14222486
83VDR_24763502_ChIP-Seq_THP-1_Human1.14162792
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.14051285
85P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13386885
86SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13063408
87OCT4_20526341_ChIP-Seq_ESCs_Human1.11093569
88RAC3_21632823_ChIP-Seq_H3396_Human1.09809554
89* TCF7_22412390_ChIP-Seq_EML_Mouse1.08589049
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08406136
91LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07357101
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06615295
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.05560846
94TP53_23651856_ChIP-Seq_MEFs_Mouse1.05402267
95P300_27268052_Chip-Seq_Bcells_Human1.04620398
96NOTCH1_21737748_ChIP-Seq_TLL_Human1.03817564
97ESR2_21235772_ChIP-Seq_MCF-7_Human1.03671676
98SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03343972
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02931107
100* CREB1_26743006_Chip-Seq_LNCaP_Human1.02122186
101PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.01869011
102RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01021165
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.00989840
104RARA_24833708_ChIP-Seq_LIVER_Mouse1.00117530
105SPI1_23127762_ChIP-Seq_K562_Human0.99923349
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99365555
107SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98981635
108CTCF_21964334_ChIP-Seq_BJAB-B_Human0.98750081
109MYC_22102868_ChIP-Seq_BL_Human0.98376770
110NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98163832
111GBX2_23144817_ChIP-Seq_PC3_Human0.98096528
112KLF4_19829295_ChIP-Seq_ESCs_Human0.97767338
113GATA1_19941826_ChIP-Seq_K562_Human0.97685542
114KDM2B_26808549_Chip-Seq_K562_Human0.97470470
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96947447
116* LXR_22292898_ChIP-Seq_THP-1_Human0.96887652
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96483938
118RARB_24833708_ChIP-Seq_LIVER_Mouse0.96381247
119GATA4_25053715_ChIP-Seq_YYC3_Human0.95436773
120UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95343192
121ESR1_20079471_ChIP-ChIP_T-47D_Human0.93676960
122P68_20966046_ChIP-Seq_HELA_Human0.92487685
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.92472966
124CTCF_27219007_Chip-Seq_Bcells_Human0.91616684
125E2F1_20622854_ChIP-Seq_HELA_Human0.91036968
126SMC4_20622854_ChIP-Seq_HELA_Human0.88127234
127FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86988404
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85961167
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.85139431
130GATA6_25053715_ChIP-Seq_YYC3_Human0.84184473
131PHF8_20622854_ChIP-Seq_HELA_Human0.83880597
132GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83761720
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81680264
134FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80453374
135BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.78727073
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78499004
137AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78424509
138GATA1_22025678_ChIP-Seq_K562_Human0.78136071
139RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78089080
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77350577
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75660092
142NFE2_27457419_Chip-Seq_LIVER_Mouse0.75435073
143NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.75296440
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.73269546
145SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73214770
146ELF1_17652178_ChIP-ChIP_JURKAT_Human0.71992064
147SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.71232593
148TP63_22573176_ChIP-Seq_HFKS_Human0.70667656
149AHR_22903824_ChIP-Seq_MCF-7_Human0.69724915
150SPI1_26923725_Chip-Seq_HPCs_Mouse0.69183826
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.68397315
152SMAD3_21741376_ChIP-Seq_HESCs_Human0.68002299
153* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67786191
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.67341455
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.67218377
156GATA2_19941826_ChIP-Seq_K562_Human0.66838676
157ELK4_26923725_Chip-Seq_MESODERM_Mouse0.66705577
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66645363
159RUNX1_27514584_Chip-Seq_MCF-7_Human0.66026162
160MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.64914038
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.63728556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.31580776
2MP0005365_abnormal_bile_salt5.15078195
3MP0005360_urolithiasis5.09345304
4MP0005085_abnormal_gallbladder_physiolo3.93741764
5MP0003252_abnormal_bile_duct3.84460401
6MP0002254_reproductive_system_inflammat3.51928939
7MP0001666_abnormal_nutrient_absorption3.07730631
8MP0010329_abnormal_lipoprotein_level2.99543122
9MP0005670_abnormal_white_adipose2.92926609
10MP0008875_abnormal_xenobiotic_pharmacok2.88319169
11MP0004264_abnormal_extraembryonic_tissu2.71809421
12MP0005174_abnormal_tail_pigmentation2.55685739
13MP0001986_abnormal_taste_sensitivity2.54292823
14MP0004858_abnormal_nervous_system2.26872064
15MP0000685_abnormal_immune_system2.24772213
16MP0005058_abnormal_lysosome_morphology2.18561390
17MP0000015_abnormal_ear_pigmentation2.14183035
18MP0002933_joint_inflammation2.00679558
19MP0009840_abnormal_foam_cell1.97212746
20MP0001800_abnormal_humoral_immune1.96372674
21MP0009384_cardiac_valve_regurgitation1.93523341
22MP0000013_abnormal_adipose_tissue1.88951714
23MP0004381_abnormal_hair_follicle1.85511109
24MP0001348_abnormal_lacrimal_gland1.84946267
25MP0003724_increased_susceptibility_to1.83791613
26MP0000569_abnormal_digit_pigmentation1.82370255
27MP0002118_abnormal_lipid_homeostasis1.80061134
28MP0004019_abnormal_vitamin_homeostasis1.78891992
29MP0000609_abnormal_liver_physiology1.78835127
30MP0003868_abnormal_feces_composition1.71370639
31MP0003191_abnormal_cellular_cholesterol1.68165392
32MP0004142_abnormal_muscle_tone1.62290074
33MP0004130_abnormal_muscle_cell1.61460225
34MP0008961_abnormal_basal_metabolism1.59547261
35MP0005332_abnormal_amino_acid1.58222750
36MP0005075_abnormal_melanosome_morpholog1.57758948
37MP0002723_abnormal_immune_serum1.56662868
38MP0003866_abnormal_defecation1.56282924
39MP0005377_hearing/vestibular/ear_phenot1.51858504
40MP0003878_abnormal_ear_physiology1.51858504
41MP0002452_abnormal_antigen_presenting1.51822541
42MP0001663_abnormal_digestive_system1.50130013
43MP0005025_abnormal_response_to1.49235705
44MP0005000_abnormal_immune_tolerance1.49221615
45MP0005220_abnormal_exocrine_pancreas1.48670443
46MP0002419_abnormal_innate_immunity1.47489860
47MP0005645_abnormal_hypothalamus_physiol1.45328398
48MP0001873_stomach_inflammation1.44793057
49MP0002653_abnormal_ependyma_morphology1.44191802
50MP0004947_skin_inflammation1.43742079
51MP0002928_abnormal_bile_duct1.43372679
52MP0005083_abnormal_biliary_tract1.41445400
53MP0000003_abnormal_adipose_tissue1.40320157
54MP0000538_abnormal_urinary_bladder1.39938339
55MP0003195_calcinosis1.37465494
56MP0001764_abnormal_homeostasis1.37412580
57MP0001270_distended_abdomen1.36846823
58MP0001819_abnormal_immune_cell1.36729257
59MP0006292_abnormal_olfactory_placode1.36702912
60MP0005319_abnormal_enzyme/_coenzyme1.36440483
61MP0002420_abnormal_adaptive_immunity1.36227119
62MP0005647_abnormal_sex_gland1.33984062
63MP0002877_abnormal_melanocyte_morpholog1.31347880
64MP0003279_aneurysm1.28377525
65MP0005451_abnormal_body_composition1.23520033
66MP0002148_abnormal_hypersensitivity_rea1.23354711
67MP0003329_amyloid_beta_deposits1.23302421
68MP0002405_respiratory_system_inflammati1.20786954
69MP0003303_peritoneal_inflammation1.20478816
70MP0001533_abnormal_skeleton_physiology1.19809920
71MP0001502_abnormal_circadian_rhythm1.19360210
72MP0001849_ear_inflammation1.18515052
73MP0009697_abnormal_copulation1.18344806
74MP0000465_gastrointestinal_hemorrhage1.17129428
75MP0009764_decreased_sensitivity_to1.15796656
76MP0003283_abnormal_digestive_organ1.15084825
77MP0005084_abnormal_gallbladder_morpholo1.13464520
78MP0005381_digestive/alimentary_phenotyp1.13418120
79MP0009643_abnormal_urine_homeostasis1.13230251
80MP0000678_abnormal_parathyroid_gland1.11739329
81MP0001984_abnormal_olfaction1.11031949
82MP0001765_abnormal_ion_homeostasis1.09766249
83MP0001958_emphysema1.08635371
84MP0005171_absent_coat_pigmentation1.07185946
85MP0000604_amyloidosis1.06409340
86MP0002009_preneoplasia1.06128924
87MP0003136_yellow_coat_color1.05056078
88MP0009765_abnormal_xenobiotic_induced1.03071335
89MP0001968_abnormal_touch/_nociception1.02759535
90MP0005409_darkened_coat_color1.02172642
91MP0002078_abnormal_glucose_homeostasis1.01641189
92MP0003646_muscle_fatigue1.01181886
93MP0008260_abnormal_autophagy1.00979382
94MP0000470_abnormal_stomach_morphology0.99843600
95MP0005499_abnormal_olfactory_system0.97607658
96MP0005394_taste/olfaction_phenotype0.97607658
97MP0002138_abnormal_hepatobiliary_system0.97297503
98MP0004043_abnormal_pH_regulation0.96927798
99MP0000716_abnormal_immune_system0.96080205
100MP0003763_abnormal_thymus_physiology0.94464167
101MP0003183_abnormal_peptide_metabolism0.94229080
102MP0002735_abnormal_chemical_nociception0.94020916
103MP0009785_altered_susceptibility_to0.93223198
104MP0006035_abnormal_mitochondrial_morpho0.93000505
105MP0000371_diluted_coat_color0.92280892
106MP0005167_abnormal_blood-brain_barrier0.91652503
107MP0002876_abnormal_thyroid_physiology0.90795639
108MP0005257_abnormal_intraocular_pressure0.90094399
109MP0005310_abnormal_salivary_gland0.88933981
110MP0001845_abnormal_inflammatory_respons0.88350677
111MP0004133_heterotaxia0.88164329
112MP0005646_abnormal_pituitary_gland0.87448986
113MP0002075_abnormal_coat/hair_pigmentati0.87094654
114MP0010386_abnormal_urinary_bladder0.84587839
115MP0003045_fibrosis0.83944254
116MP0005448_abnormal_energy_balance0.83197775
117MP0002693_abnormal_pancreas_physiology0.82570243
118MP0001944_abnormal_pancreas_morphology0.82535568
119MP0003806_abnormal_nucleotide_metabolis0.82503505
120MP0006054_spinal_hemorrhage0.82350928
121MP0005551_abnormal_eye_electrophysiolog0.81620044
122MP0005423_abnormal_somatic_nervous0.81416126
123MP0008469_abnormal_protein_level0.80610774
124MP0009642_abnormal_blood_homeostasis0.80358833
125MP0003787_abnormal_imprinting0.80213864
126MP0006072_abnormal_retinal_apoptosis0.78809255
127MP0009763_increased_sensitivity_to0.78309004
128MP0009333_abnormal_splenocyte_physiolog0.77517073
129MP0004147_increased_porphyrin_level0.76270441
130MP0001835_abnormal_antigen_presentation0.74698875
131MP0001970_abnormal_pain_threshold0.74076550
132MP0004885_abnormal_endolymph0.73997510
133MP0009278_abnormal_bone_marrow0.73717174
134MP0000598_abnormal_liver_morphology0.73316306
135MP0005334_abnormal_fat_pad0.72236000
136MP0001661_extended_life_span0.72213390
137MP0003953_abnormal_hormone_level0.71333751
138MP0005464_abnormal_platelet_physiology0.70711767
139MP0005584_abnormal_enzyme/coenzyme_acti0.70387123
140MP0002229_neurodegeneration0.69374006
141MP0002429_abnormal_blood_cell0.68698653
142MP0005387_immune_system_phenotype0.68656405
143MP0001790_abnormal_immune_system0.68656405
144MP0000613_abnormal_salivary_gland0.66905245
145MP0002132_abnormal_respiratory_system0.66471633
146MP0010155_abnormal_intestine_physiology0.65559784
147MP0006082_CNS_inflammation0.63174055
148MP0000383_abnormal_hair_follicle0.62728660
149MP0008789_abnormal_olfactory_epithelium0.60792744
150MP0002822_catalepsy0.58480134
151MP0002136_abnormal_kidney_physiology0.57002006
152MP0005671_abnormal_response_to0.56980538
153MP0005367_renal/urinary_system_phenotyp0.55957353
154MP0000516_abnormal_urinary_system0.55957353
155MP0003436_decreased_susceptibility_to0.54448884
156MP0001756_abnormal_urination0.54445630
157MP0002971_abnormal_brown_adipose0.53705368
158MP0001324_abnormal_eye_pigmentation0.51854333
159MP0003172_abnormal_lysosome_physiology0.51263498

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.06506034
2Intrahepatic cholestasis (HP:0001406)3.85881619
3Conjugated hyperbilirubinemia (HP:0002908)3.58730847
4Hyperglycinuria (HP:0003108)3.49424880
5Chronic hepatic failure (HP:0100626)3.40523870
6Pustule (HP:0200039)3.27312336
7Hemorrhage of the eye (HP:0011885)3.22512082
8Congenital stationary night blindness (HP:0007642)3.12649443
9Hypoglycemic seizures (HP:0002173)3.10601239
10Prolonged partial thromboplastin time (HP:0003645)3.06608460
11Hyperinsulinemic hypoglycemia (HP:0000825)3.04177409
12Abnormality of polysaccharide metabolism (HP:0011012)2.94181969
13Hypoglycemic coma (HP:0001325)2.92500953
14Generalized hyperpigmentation (HP:0007440)2.89743063
15Symptomatic seizures (HP:0011145)2.88578081
16Type II lissencephaly (HP:0007260)2.86746544
17Ketosis (HP:0001946)2.84856083
18Thin bony cortex (HP:0002753)2.84831095
19Abnormal biliary tract physiology (HP:0012439)2.84502519
20Bile duct proliferation (HP:0001408)2.84502519
21Renal cortical cysts (HP:0000803)2.79651879
22Joint hemorrhage (HP:0005261)2.78094708
23Clumsiness (HP:0002312)2.76510716
24Increased neuronal autofluorescent lipopigment (HP:0002074)2.74932653
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71563714
26Mucopolysacchariduria (HP:0008155)2.71153122
27Urinary glycosaminoglycan excretion (HP:0003541)2.71153122
28Abnormality of monocarboxylic acid metabolism (HP:0010996)2.70715216
29Ketoacidosis (HP:0001993)2.70111283
30Chronic mucocutaneous candidiasis (HP:0002728)2.67615760
31Recurrent cutaneous fungal infections (HP:0011370)2.67615760
32Genetic anticipation (HP:0003743)2.64779614
33Abnormal pancreas size (HP:0012094)2.60981823
34Abnormality of serine family amino acid metabolism (HP:0010894)2.56298838
35Abnormality of glycine metabolism (HP:0010895)2.56298838
36Increased cerebral lipofuscin (HP:0011813)2.55231723
37Attenuation of retinal blood vessels (HP:0007843)2.53856054
38Myositis (HP:0100614)2.53477239
39Abnormality of the intrinsic pathway (HP:0010989)2.52562159
40Enlarged kidneys (HP:0000105)2.51803057
41Molar tooth sign on MRI (HP:0002419)2.50859581
42Abnormality of midbrain morphology (HP:0002418)2.50859581
43Xanthomatosis (HP:0000991)2.46819641
44Generalized aminoaciduria (HP:0002909)2.45191957
45Dysostosis multiplex (HP:0000943)2.44529096
46Cervical subluxation (HP:0003308)2.44034426
47Hyperglycemia (HP:0003074)2.40580585
48Keratoconus (HP:0000563)2.39608203
49Increased corneal curvature (HP:0100692)2.39608203
50Anal stenosis (HP:0002025)2.37656666
51Right ventricular cardiomyopathy (HP:0011663)2.37576332
52Abnormality of sulfur amino acid metabolism (HP:0004339)2.36336301
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.36259436
54Recurrent fungal infections (HP:0002841)2.35334345
55Fat malabsorption (HP:0002630)2.31912015
56Deep venous thrombosis (HP:0002625)2.31645823
57Hyperglycinemia (HP:0002154)2.30741604
58Confusion (HP:0001289)2.29985379
59Stomatitis (HP:0010280)2.29358366
60Abnormality of liposaccharide metabolism (HP:0010968)2.29077669
61Abnormality of glycosphingolipid metabolism (HP:0004343)2.29077669
62Abnormality of glycolipid metabolism (HP:0010969)2.29077669
63Congenital hepatic fibrosis (HP:0002612)2.28941165
64Hyperlipoproteinemia (HP:0010980)2.28324024
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.28021886
66Abnormality of DNA repair (HP:0003254)2.26850317
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.25898236
68Abnormality of fatty-acid metabolism (HP:0004359)2.24410302
69Lissencephaly (HP:0001339)2.23341820
70Gingival bleeding (HP:0000225)2.22023684
71J-shaped sella turcica (HP:0002680)2.18874533
72Joint stiffness (HP:0001387)2.18338680
73Colitis (HP:0002583)2.17853209
74Hyperammonemia (HP:0001987)2.16263696
75Entropion (HP:0000621)2.15159943
76Status epilepticus (HP:0002133)2.15049916
77Autoimmune thrombocytopenia (HP:0001973)2.14715323
78Severe muscular hypotonia (HP:0006829)2.12357499
79Pseudobulbar signs (HP:0002200)2.12040582
80Hypercholesterolemia (HP:0003124)2.11957532
81Central scotoma (HP:0000603)2.11953990
82Retrobulbar optic neuritis (HP:0100654)2.11906734
83Optic neuritis (HP:0100653)2.11906734
84Nephronophthisis (HP:0000090)2.11732102
85Epidermoid cyst (HP:0200040)2.11283537
86Anterior segment dysgenesis (HP:0007700)2.11036272
87Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.10893347
88Hypobetalipoproteinemia (HP:0003563)2.10131352
89Protruding tongue (HP:0010808)2.08287445
90Reduced antithrombin III activity (HP:0001976)2.06903233
91Hypochromic anemia (HP:0001931)2.06683214
92Progressive sensorineural hearing impairment (HP:0000408)2.06175413
93Intestinal atresia (HP:0011100)2.06042953
94Disproportionate short-trunk short stature (HP:0003521)2.04118166
95Orchitis (HP:0100796)2.02897746
96Abnormality of pyrimidine metabolism (HP:0004353)2.02189340
97Hyperbilirubinemia (HP:0002904)2.02150621
98Hemiplegia (HP:0002301)2.01619451
99Hyperacusis (HP:0010780)2.00605695
100Abnormality of endocrine pancreas physiology (HP:0012093)2.00096654
101Abnormality of the pancreatic islet cells (HP:0006476)2.00096654
102Agitation (HP:0000713)1.99199700
103Febrile seizures (HP:0002373)1.97869224
104Malnutrition (HP:0004395)1.96800399
105Hypoalphalipoproteinemia (HP:0003233)1.96751067
106Rough bone trabeculation (HP:0100670)1.96128719
107Abnormality of nucleobase metabolism (HP:0010932)1.94885655
108Cheilitis (HP:0100825)1.92236067
109Ragged-red muscle fibers (HP:0003200)1.91288357
110Abnormality of purine metabolism (HP:0004352)1.91233813
111Aplasia/Hypoplasia affecting the retina (HP:0008061)1.90618762
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.89682029
113Metabolic acidosis (HP:0001942)1.89538305
114Elevated erythrocyte sedimentation rate (HP:0003565)1.88139664
115Annular pancreas (HP:0001734)1.87429657
116Increased IgM level (HP:0003496)1.87001676
117Abnormality of the renal cortex (HP:0011035)1.85945537
118Dicarboxylic aciduria (HP:0003215)1.85055988
119Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85055988
120Hypolipoproteinemia (HP:0010981)1.84763374
121Abnormal rod and cone electroretinograms (HP:0008323)1.84348639
122Decreased central vision (HP:0007663)1.83198659
123Cystic liver disease (HP:0006706)1.82847386
124Enlarged epiphyses (HP:0010580)1.82623228
125IgG deficiency (HP:0004315)1.82051692
126Abnormality of T cell physiology (HP:0011840)1.80999575
127Tetraplegia (HP:0002445)1.80917747
128Abnormality of the renal medulla (HP:0100957)1.80721693
129Poikiloderma (HP:0001029)1.79140699
130Keratitis (HP:0000491)1.79045895
131Retinal dysplasia (HP:0007973)1.78922711
132Type I transferrin isoform profile (HP:0003642)1.78632857
133Melanoma (HP:0002861)1.78140818
134Myocardial infarction (HP:0001658)1.78010904
135Vacuolated lymphocytes (HP:0001922)1.77971799
136Abnormality of the fingertips (HP:0001211)1.77940300
137Atrophic scars (HP:0001075)1.77830149
138Abnormality of macrophages (HP:0004311)1.76573506
139Stridor (HP:0010307)1.76530978
140Decreased circulating renin level (HP:0003351)1.75372845
141Gastrointestinal infarctions (HP:0005244)1.74514215
142Abnormality of the common coagulation pathway (HP:0010990)1.74244987
143Pancreatic cysts (HP:0001737)1.74218222
144Aplasia/Hypoplasia of the spleen (HP:0010451)1.74215272
145Sensorimotor neuropathy (HP:0007141)1.74139440
146Inflammation of the large intestine (HP:0002037)1.73760437
147Progressive cerebellar ataxia (HP:0002073)1.73522215
148Stomach cancer (HP:0012126)1.73350296
149Eczematoid dermatitis (HP:0000976)1.72510171
150Pendular nystagmus (HP:0012043)1.71962865
151Hemoptysis (HP:0002105)1.71489134
152Flat capital femoral epiphysis (HP:0003370)1.70852376
153Opisthotonus (HP:0002179)1.70602548
154Hypoplasia of the brainstem (HP:0002365)1.69198248
155Aplasia/Hypoplasia of the brainstem (HP:0007362)1.69198248
156Cortical visual impairment (HP:0100704)1.68951240
157Gout (HP:0001997)1.68447192
158Hypoplasia of the fovea (HP:0007750)1.68245348
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.68245348
160Optic nerve coloboma (HP:0000588)1.67837312
161Abnormality of the hepatic vasculature (HP:0006707)1.67542107
162Bulbous nose (HP:0000414)1.67341808
163Pigmentary retinal degeneration (HP:0001146)1.67161775
164Pancreatic islet-cell hyperplasia (HP:0004510)1.66150629
165Retinal atrophy (HP:0001105)1.66094259
166Hypochromic microcytic anemia (HP:0004840)1.65196394
167Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.64790840
168Epileptic encephalopathy (HP:0200134)1.64504147
169Large eyes (HP:0001090)1.64385582
170True hermaphroditism (HP:0010459)1.64251285
171Esophageal varix (HP:0002040)1.64236128
172Prolonged neonatal jaundice (HP:0006579)1.64118768
173Abnormality of the columella (HP:0009929)1.63923171
174Aplasia/Hypoplasia of the patella (HP:0006498)1.63623912
175Abnormality of mucopolysaccharide metabolism (HP:0011020)1.63599552
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.63599552
177Milia (HP:0001056)1.63260909
178Persistence of primary teeth (HP:0006335)1.63226385
179Ectropion (HP:0000656)1.63168771
180Rectal prolapse (HP:0002035)1.62496080
181Abnormality of the thoracic spine (HP:0100711)1.61677106
182Pulmonary infiltrates (HP:0002113)1.60943282
183Supernumerary nipples (HP:0002558)1.60911848
184Macroglossia (HP:0000158)1.60756723
185Easy fatigability (HP:0003388)1.60399880
186Long palpebral fissure (HP:0000637)1.60243827
187Patellar aplasia (HP:0006443)1.60163362
188Rib fusion (HP:0000902)1.58713476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.60316177
2INSRR4.09561078
3CDK123.24984821
4TLK12.99335162
5PRPF4B2.97848589
6AKT32.96122019
7BCKDK2.75884526
8BRD42.64437368
9TRIB32.63435902
10WNK42.26698491
11SIK12.05345344
12IRAK31.99624238
13LATS11.90533828
14MAP3K141.89048678
15MAP4K11.86896048
16CAMKK11.78374045
17ZAK1.77005369
18EPHA21.51282829
19GRK11.51110360
20SGK21.48919170
21CAMK1D1.47140402
22GRK61.43138356
23TXK1.37860206
24MAPK151.37278027
25NTRK21.34276002
26BLK1.33536305
27MAP2K61.32387492
28TYK21.31240752
29PKN21.31142888
30DYRK31.31069125
31JAK11.28735010
32FGFR41.28653394
33TIE11.26937814
34YES11.26553952
35CAMKK21.19068957
36ITK1.18335957
37BMPR1B1.15073185
38EPHA31.14755337
39SGK31.11574434
40TAOK31.08531769
41SIK21.05993507
42PINK11.03474121
43MAP2K31.02558943
44RIPK41.02242119
45CHUK1.00564945
46FRK1.00545439
47TYRO30.99202720
48HIPK20.98680569
49MAP3K110.96620704
50TNK20.96571825
51DAPK20.93295449
52MAPK70.92936705
53IKBKE0.92312984
54IRAK40.92034267
55MTOR0.91922953
56PRKAA10.91860224
57MAP3K70.89600563
58PRKD30.88739497
59NLK0.88498667
60CAMK1G0.88249394
61MAPK110.87507670
62PRKAA20.87399431
63CAMK40.87036602
64ICK0.86102515
65ACVR1B0.85992890
66WNK10.84205999
67PRKD20.83774648
68RPS6KA20.81999836
69SYK0.79737105
70FLT30.79500896
71RIPK10.78820086
72MATK0.76896638
73MAP2K20.76876164
74PIM20.76675954
75JAK30.75120384
76CASK0.72234300
77SGK4940.72198008
78SGK2230.72198008
79ADRBK10.71984213
80MAPK120.71896878
81PIK3CA0.71282022
82IKBKB0.71051733
83PASK0.70583863
84MARK30.68462177
85TAOK20.68038113
86STK380.67993539
87RPS6KL10.66754041
88RPS6KC10.66754041
89SIK30.65340094
90EEF2K0.63931088
91MUSK0.63093627
92ZAP700.62199612
93BTK0.61715151
94RPS6KA60.60485210
95BMX0.60269884
96MAP3K60.59152039
97CDC42BPA0.58868058
98HCK0.58382530
99RET0.58233531
100PTK2B0.58010320
101PTK60.57443153
102ATR0.56468105
103PDK10.56304704
104PDPK10.56128928
105PRKCQ0.56040364
106MAPK130.55873388
107TBK10.55121607
108KIT0.54397160
109TEC0.52912539
110TGFBR10.52453609
111MAP3K10.51653384
112EIF2AK20.50538496
113STK110.49362596
114CDK90.48904932
115EPHB10.48885183
116GSK3A0.48052760
117IRAK10.47772939
118NUAK10.47111567
119ERBB20.46954761
120NTRK10.46853013
121ADRBK20.46849791
122MARK20.46642883
123CSF1R0.46368284
124PTK20.45779677
125CSK0.45581965
126MAP3K100.45536843
127DYRK1A0.45439976
128DYRK1B0.45367719
129NTRK30.43870493
130MAPK10.41297658
131MAP3K130.40606287
132AKT10.40582118
133LCK0.39862217
134PRKCH0.39723707
135MAPK30.39425542
136CDK40.39075908
137PRKG10.38960223
138CDK30.38107209
139TGFBR20.37801296
140PRKCI0.36984202

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.17554046
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.12738890
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.74765324
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.61915224
5Vitamin B6 metabolism_Homo sapiens_hsa007502.49344875
6Vitamin digestion and absorption_Homo sapiens_hsa049772.44159454
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42460049
8Tryptophan metabolism_Homo sapiens_hsa003802.28280846
9Selenocompound metabolism_Homo sapiens_hsa004502.12766785
10Fatty acid degradation_Homo sapiens_hsa000712.02287507
11* ABC transporters_Homo sapiens_hsa020101.95085030
12Graft-versus-host disease_Homo sapiens_hsa053321.94916983
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93527517
14Allograft rejection_Homo sapiens_hsa053301.92744548
15Peroxisome_Homo sapiens_hsa041461.87369179
16Autoimmune thyroid disease_Homo sapiens_hsa053201.81675145
17Arginine biosynthesis_Homo sapiens_hsa002201.80391939
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.80282494
19Lysine degradation_Homo sapiens_hsa003101.77966278
20beta-Alanine metabolism_Homo sapiens_hsa004101.76082837
21Starch and sucrose metabolism_Homo sapiens_hsa005001.64867167
22Fatty acid metabolism_Homo sapiens_hsa012121.64746080
23Butanoate metabolism_Homo sapiens_hsa006501.63631202
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.62807468
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61631388
26PPAR signaling pathway_Homo sapiens_hsa033201.60937971
27Bile secretion_Homo sapiens_hsa049761.60834710
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.60278142
29Folate biosynthesis_Homo sapiens_hsa007901.59644869
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.56088679
31Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50998219
32Asthma_Homo sapiens_hsa053101.50330910
33Lysosome_Homo sapiens_hsa041421.50163605
34Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.48360998
35Circadian rhythm_Homo sapiens_hsa047101.48230214
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48084870
37Histidine metabolism_Homo sapiens_hsa003401.46691438
38T cell receptor signaling pathway_Homo sapiens_hsa046601.44995522
39Retinol metabolism_Homo sapiens_hsa008301.38237276
40Sulfur metabolism_Homo sapiens_hsa009201.34828260
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32826461
42B cell receptor signaling pathway_Homo sapiens_hsa046621.32574558
43Complement and coagulation cascades_Homo sapiens_hsa046101.31043163
44Fat digestion and absorption_Homo sapiens_hsa049751.28878470
45VEGF signaling pathway_Homo sapiens_hsa043701.28861235
46Osteoclast differentiation_Homo sapiens_hsa043801.28007169
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27833227
48Galactose metabolism_Homo sapiens_hsa000521.27711573
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.24484427
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21058582
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.20977471
52Phenylalanine metabolism_Homo sapiens_hsa003601.20089248
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19194308
54Leishmaniasis_Homo sapiens_hsa051401.17067574
55Chemical carcinogenesis_Homo sapiens_hsa052041.13864845
56Toxoplasmosis_Homo sapiens_hsa051451.13842038
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10757738
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10610620
59Acute myeloid leukemia_Homo sapiens_hsa052211.08916724
60Propanoate metabolism_Homo sapiens_hsa006401.05573834
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04535111
62TNF signaling pathway_Homo sapiens_hsa046681.03276361
63Glycerolipid metabolism_Homo sapiens_hsa005611.02322099
64NOD-like receptor signaling pathway_Homo sapiens_hsa046211.00880877
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96904324
66Tuberculosis_Homo sapiens_hsa051520.95948615
67Ether lipid metabolism_Homo sapiens_hsa005650.95858613
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94705286
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94320774
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.93838146
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93374479
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93266855
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92900102
74Dorso-ventral axis formation_Homo sapiens_hsa043200.90703138
75Fructose and mannose metabolism_Homo sapiens_hsa000510.90688990
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.89989683
77Insulin resistance_Homo sapiens_hsa049310.87918047
78Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87443334
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.86022964
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.84530688
81mTOR signaling pathway_Homo sapiens_hsa041500.84274104
82Chemokine signaling pathway_Homo sapiens_hsa040620.82192948
83Fatty acid biosynthesis_Homo sapiens_hsa000610.82077811
84Caffeine metabolism_Homo sapiens_hsa002320.81495874
85Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80480570
86Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79696193
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78912649
88Staphylococcus aureus infection_Homo sapiens_hsa051500.77745213
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77617885
90Axon guidance_Homo sapiens_hsa043600.77110509
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.76047770
92Platelet activation_Homo sapiens_hsa046110.75352151
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.75292038
94Prolactin signaling pathway_Homo sapiens_hsa049170.75004356
95Rheumatoid arthritis_Homo sapiens_hsa053230.74876667
96Hematopoietic cell lineage_Homo sapiens_hsa046400.74423290
97Arginine and proline metabolism_Homo sapiens_hsa003300.73292183
98Mineral absorption_Homo sapiens_hsa049780.72953587
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71715688
100Hepatitis C_Homo sapiens_hsa051600.70135198
101African trypanosomiasis_Homo sapiens_hsa051430.69805097
102MAPK signaling pathway_Homo sapiens_hsa040100.68963636
103GnRH signaling pathway_Homo sapiens_hsa049120.68757933
104Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68325257
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68196201
106Phototransduction_Homo sapiens_hsa047440.67629994
107Aldosterone synthesis and secretion_Homo sapiens_hsa049250.65478037
108Tyrosine metabolism_Homo sapiens_hsa003500.65046716
109Morphine addiction_Homo sapiens_hsa050320.64411579
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.64116698
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.62800655
112Antigen processing and presentation_Homo sapiens_hsa046120.62762665
113Ovarian steroidogenesis_Homo sapiens_hsa049130.62252392
114Nicotine addiction_Homo sapiens_hsa050330.62079318
115Type II diabetes mellitus_Homo sapiens_hsa049300.60858214
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59283050
117Insulin secretion_Homo sapiens_hsa049110.58679676
118Choline metabolism in cancer_Homo sapiens_hsa052310.56224277
119Inositol phosphate metabolism_Homo sapiens_hsa005620.55988320
120Oxytocin signaling pathway_Homo sapiens_hsa049210.55320783
121Taste transduction_Homo sapiens_hsa047420.54504517
122Cholinergic synapse_Homo sapiens_hsa047250.54280013
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.54098117
124alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53867287
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53771178
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53057757
127ErbB signaling pathway_Homo sapiens_hsa040120.51843654
128Primary immunodeficiency_Homo sapiens_hsa053400.51501383
129Apoptosis_Homo sapiens_hsa042100.51337226
130Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50846610
131Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50589120
132Regulation of autophagy_Homo sapiens_hsa041400.50580865
133Measles_Homo sapiens_hsa051620.50441075
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.50012778
135Other glycan degradation_Homo sapiens_hsa005110.49974508
136Ras signaling pathway_Homo sapiens_hsa040140.48653067
137Viral myocarditis_Homo sapiens_hsa054160.48123617
138Malaria_Homo sapiens_hsa051440.46672206
139One carbon pool by folate_Homo sapiens_hsa006700.46551668
140Protein digestion and absorption_Homo sapiens_hsa049740.46550421
141Non-small cell lung cancer_Homo sapiens_hsa052230.46447386
142Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44975146
143Notch signaling pathway_Homo sapiens_hsa043300.44625879
144Calcium signaling pathway_Homo sapiens_hsa040200.43536240
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.41590564
146Sulfur relay system_Homo sapiens_hsa041220.39671594
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.38988410
148Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37514620
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36777792
150Biosynthesis of amino acids_Homo sapiens_hsa012300.36620207
151Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36415604
152AMPK signaling pathway_Homo sapiens_hsa041520.35966044
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32981954
154Glycosaminoglycan degradation_Homo sapiens_hsa005310.30448983
155Sphingolipid metabolism_Homo sapiens_hsa006000.30252175
156Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29933083
157Linoleic acid metabolism_Homo sapiens_hsa005910.29732672
158Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.29362828
159Steroid biosynthesis_Homo sapiens_hsa001000.29334947
160Glucagon signaling pathway_Homo sapiens_hsa049220.28327418
161Type I diabetes mellitus_Homo sapiens_hsa049400.27804492
162Metabolic pathways_Homo sapiens_hsa011000.26164239
163Pyruvate metabolism_Homo sapiens_hsa006200.26025501
164Influenza A_Homo sapiens_hsa051640.25378931
165Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25371610
166Fatty acid elongation_Homo sapiens_hsa000620.22934305

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »