ABCC11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prostate gland growth (GO:0060736)8.97607428
2ovulation from ovarian follicle (GO:0001542)7.07309218
3mammary gland epithelial cell differentiation (GO:0060644)7.06063772
4epithelial cell maturation (GO:0002070)6.80256749
5iron ion import (GO:0097286)6.75931566
6Golgi transport vesicle coating (GO:0048200)6.34306051
7COPI coating of Golgi vesicle (GO:0048205)6.34306051
8short-chain fatty acid metabolic process (GO:0046459)6.09009407
9activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)6.07387174
10biotin metabolic process (GO:0006768)6.05778624
11mammary gland alveolus development (GO:0060749)5.92998776
12intestinal epithelial cell development (GO:0060576)5.15520898
13negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)4.85737327
14regulation of water loss via skin (GO:0033561)4.69546253
15diol metabolic process (GO:0034311)4.49055172
16regulation of cytokine production involved in inflammatory response (GO:1900015)4.41573366
17establishment of skin barrier (GO:0061436)4.13411576
18sphingoid metabolic process (GO:0046519)4.09194539
19carnitine metabolic process (GO:0009437)4.08855359
20benzene-containing compound metabolic process (GO:0042537)3.92964030
21growth hormone receptor signaling pathway (GO:0060396)3.85823461
22cardiac right ventricle morphogenesis (GO:0003215)3.70819135
23regulation of hippo signaling (GO:0035330)3.69297432
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66969363
25regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)3.64895732
26multicellular organismal water homeostasis (GO:0050891)3.63757262
27COPII vesicle coating (GO:0048208)3.62235812
28desmosome organization (GO:0002934)3.62003696
29insulin-like growth factor receptor signaling pathway (GO:0048009)3.58634162
30branching involved in mammary gland duct morphogenesis (GO:0060444)3.50983795
31valine metabolic process (GO:0006573)3.50319076
32NLS-bearing protein import into nucleus (GO:0006607)3.46403050
33regulation of establishment or maintenance of cell polarity (GO:0032878)3.45833341
34keratinocyte development (GO:0003334)3.45037240
35prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.42571796
36water homeostasis (GO:0030104)3.40643367
37positive regulation of keratinocyte differentiation (GO:0045618)3.39904879
38peptidyl-lysine dimethylation (GO:0018027)3.38168527
39regulation of lipoprotein metabolic process (GO:0050746)3.37138456
40regulation of protein localization to cell surface (GO:2000008)3.32073025
41regulation of female receptivity (GO:0045924)3.31209357
42cellular response to growth hormone stimulus (GO:0071378)3.30787003
43amino-acid betaine metabolic process (GO:0006577)3.29942314
44amino-acid betaine transport (GO:0015838)3.29325395
45carnitine transport (GO:0015879)3.29325395
46regulation of clathrin-mediated endocytosis (GO:2000369)3.26614059
47positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.23197210
48trivalent inorganic anion homeostasis (GO:0072506)3.22566391
49phosphate ion homeostasis (GO:0055062)3.22566391
50ovulation (GO:0030728)3.22154937
51lung lobe morphogenesis (GO:0060463)3.18932977
52glucocorticoid metabolic process (GO:0008211)3.18453235
53retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.18321022
54bundle of His cell to Purkinje myocyte communication (GO:0086069)3.16198853
55face development (GO:0060324)3.13011149
56renal system development (GO:0072001)3.11106213
57endocrine hormone secretion (GO:0060986)3.08941083
58regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.04978240
59branched-chain amino acid metabolic process (GO:0009081)3.04847953
60G1 DNA damage checkpoint (GO:0044783)3.02450981
61cellular modified amino acid catabolic process (GO:0042219)3.00702961
62mitotic G1 DNA damage checkpoint (GO:0031571)2.99147281
63autophagic vacuole fusion (GO:0000046)2.97996057
64branched-chain amino acid catabolic process (GO:0009083)2.96994134
65branching involved in prostate gland morphogenesis (GO:0060442)2.94672477
66surfactant homeostasis (GO:0043129)2.94578467
67exocrine pancreas development (GO:0031017)2.93734368
68lung secretory cell differentiation (GO:0061140)2.92651738
69RNA-dependent DNA replication (GO:0006278)2.92472145
70dicarboxylic acid catabolic process (GO:0043649)2.87642490
71proline metabolic process (GO:0006560)2.87009875
72sex differentiation (GO:0007548)2.85620735
73chemical homeostasis within a tissue (GO:0048875)2.84700390
74embryo implantation (GO:0007566)2.83214975
75carnitine shuttle (GO:0006853)2.82657544
76regulation of fatty acid beta-oxidation (GO:0031998)2.82632921
77regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.82323299
78JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.82258260
79O-glycan processing (GO:0016266)2.82253346
80sphingosine metabolic process (GO:0006670)2.81090715
81regulation of Golgi to plasma membrane protein transport (GO:0042996)2.79130576
82retina homeostasis (GO:0001895)2.77631213
83ER overload response (GO:0006983)2.77501124
84very long-chain fatty acid metabolic process (GO:0000038)2.74997084
85primary alcohol catabolic process (GO:0034310)2.74293502
86quaternary ammonium group transport (GO:0015697)2.74140912
87dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70934314
88heparin metabolic process (GO:0030202)2.70559849
89heparin biosynthetic process (GO:0030210)2.70559849
90female mating behavior (GO:0060180)2.69582055
91tight junction assembly (GO:0070830)2.69404687
92linoleic acid metabolic process (GO:0043651)2.66842757
93oocyte development (GO:0048599)2.65321534
94endothelial cell chemotaxis (GO:0035767)2.64806080
95cranial suture morphogenesis (GO:0060363)2.64569796
96copper ion transport (GO:0006825)2.64342017
97ear development (GO:0043583)2.62315302
98vesicle coating (GO:0006901)2.58397348
99lung epithelial cell differentiation (GO:0060487)2.58278993
100DNA methylation involved in gamete generation (GO:0043046)2.57367933

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human4.88373957
2ESR2_21235772_ChIP-Seq_MCF-7_Human4.52754869
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.47962227
4ESR1_15608294_ChIP-ChIP_MCF-7_Human4.05488713
5ELF5_23300383_ChIP-Seq_T47D_Human3.84753840
6ZNF217_24962896_ChIP-Seq_MCF-7_Human3.26969918
7ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.96271412
8ZNF263_19887448_ChIP-Seq_K562_Human2.82837166
9* GATA3_24758297_ChIP-Seq_MCF-7_Human2.69416489
10KDM5A_27292631_Chip-Seq_BREAST_Human2.52731573
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51718995
12AR_21909140_ChIP-Seq_LNCAP_Human2.50244424
13RUNX1_27514584_Chip-Seq_MCF-7_Human2.45715398
14FOXM1_26456572_ChIP-Seq_MCF-7_Human2.40122847
15AHR_22903824_ChIP-Seq_MCF-7_Human2.37553675
16TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.32729509
17FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.31989539
18* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.23483472
19ARNT_22903824_ChIP-Seq_MCF-7_Human2.20595962
20* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.15749660
21* ESR1_20079471_ChIP-ChIP_T-47D_Human11.7075179
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94237874
23HOXB7_26014856_ChIP-Seq_BT474_Human1.86023149
24ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.79259178
25SOX2_27498859_Chip-Seq_STOMACH_Mouse1.78363101
26FOXA1_25552417_ChIP-Seq_VCAP_Human1.76928226
27* RACK7_27058665_Chip-Seq_MCF-7_Human1.75384450
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.74915915
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70450223
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.69636139
31CHD1_26751641_Chip-Seq_LNCaP_Human1.67816831
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.63735406
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60395450
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60144072
35GATA6_25053715_ChIP-Seq_YYC3_Human1.59770648
36* GATA4_25053715_ChIP-Seq_YYC3_Human1.58986334
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.55224140
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.53783891
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53457157
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.53346901
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50491389
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.32486073
43ER_23166858_ChIP-Seq_MCF-7_Human1.29183701
44* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.24214183
45PKCTHETA_26484144_Chip-Seq_BREAST_Human1.12397103
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10748941
47CLOCK_20551151_ChIP-Seq_293T_Human1.07943237
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04468732
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.02813312
50KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02745142
51CBP_21632823_ChIP-Seq_H3396_Human1.02154012
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01693116
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.00887925
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99469595
55EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97689116
56FOXO3_23340844_ChIP-Seq_DLD1_Human0.94960318
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93413675
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.93108845
59HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.92412193
60CDX2_20551321_ChIP-Seq_CACO-2_Human0.90467771
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87904105
62KLF5_25053715_ChIP-Seq_YYC3_Human0.87903418
63PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83128160
64JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82606124
65ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79348868
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.77829505
67TP63_19390658_ChIP-ChIP_HaCaT_Human0.77791085
68GABP_17652178_ChIP-ChIP_JURKAT_Human0.77467509
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.77435267
70CDX2_22108803_ChIP-Seq_LS180_Human0.75525712
71SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75098623
72NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.74740756
73TRIM28_21343339_ChIP-Seq_HEK293_Human0.73861133
74HTT_18923047_ChIP-ChIP_STHdh_Human0.73263776
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.72934777
76ATF3_27146783_Chip-Seq_COLON_Human0.72528763
77BCAT_22108803_ChIP-Seq_LS180_Human0.72297570
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71022017
79MYCN_18555785_ChIP-Seq_MESCs_Mouse0.70569619
80CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.69666222
81SOX2_20726797_ChIP-Seq_SW620_Human0.69389325
82P63_26484246_Chip-Seq_KERATINOCYTES_Human0.68962748
83E2F1_21310950_ChIP-Seq_MCF-7_Human0.67569206
84CREB1_26743006_Chip-Seq_LNCaP_Human0.67513902
85KLF4_18555785_Chip-Seq_ESCs_Mouse0.67237535
86AR_21572438_ChIP-Seq_LNCaP_Human0.66420709
87AR_20517297_ChIP-Seq_VCAP_Human0.65960250
88ELK1_19687146_ChIP-ChIP_HELA_Human0.64748685
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.64544711
90ZFX_18555785_ChIP-Seq_MESCs_Mouse0.63708697
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.62944841
92DCP1A_22483619_ChIP-Seq_HELA_Human0.62106891
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.61774656
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.61757594
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.60526141
96CTCF_18555785_Chip-Seq_ESCs_Mouse0.60207009
97* FOXA2_19822575_ChIP-Seq_HepG2_Human0.59966605
98FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.59959376
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.59918666
100FOXA1_27270436_Chip-Seq_PROSTATE_Human0.59918666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat6.87461710
2MP0001346_abnormal_lacrimal_gland5.39725755
3MP0005248_abnormal_Harderian_gland5.01956826
4MP0004264_abnormal_extraembryonic_tissu3.86292924
5MP0003183_abnormal_peptide_metabolism3.79264120
6MP0010234_abnormal_vibrissa_follicle3.59855208
7MP0005379_endocrine/exocrine_gland_phen3.51500407
8MP0001919_abnormal_reproductive_system3.24128759
9MP0003191_abnormal_cellular_cholesterol3.13981595
10MP0005408_hypopigmentation3.06606677
11MP0002009_preneoplasia2.96478218
12MP0000427_abnormal_hair_cycle2.77709934
13MP0000566_synostosis2.71039515
14MP0005083_abnormal_biliary_tract2.70338570
15MP0001881_abnormal_mammary_gland2.64602922
16MP0000537_abnormal_urethra_morphology2.59659991
17MP0002796_impaired_skin_barrier2.51492703
18MP0003941_abnormal_skin_development2.50128185
19MP0000627_abnormal_mammary_gland2.46149697
20MP0002098_abnormal_vibrissa_morphology2.32972173
21MP0002166_altered_tumor_susceptibility2.15709451
22MP0009780_abnormal_chondrocyte_physiolo2.11478777
23MP0004782_abnormal_surfactant_physiolog2.09900231
24MP0009384_cardiac_valve_regurgitation1.90561938
25MP0002282_abnormal_trachea_morphology1.80836096
26MP0005389_reproductive_system_phenotype1.76228762
27MP0010678_abnormal_skin_adnexa1.72742413
28MP0004233_abnormal_muscle_weight1.68106198
29MP0001666_abnormal_nutrient_absorption1.66082942
30MP0003936_abnormal_reproductive_system1.63286574
31MP0001727_abnormal_embryo_implantation1.58573297
32MP0000383_abnormal_hair_follicle1.51794085
33MP0001765_abnormal_ion_homeostasis1.44152148
34MP0000579_abnormal_nail_morphology1.43104209
35MP0001873_stomach_inflammation1.42826558
36MP0003315_abnormal_perineum_morphology1.42352821
37MP0002006_tumorigenesis1.40785251
38MP0000681_abnormal_thyroid_gland1.38440311
39MP0002909_abnormal_adrenal_gland1.36116205
40MP0005310_abnormal_salivary_gland1.33496453
41MP0005501_abnormal_skin_physiology1.32582333
42MP0005636_abnormal_mineral_homeostasis1.30335049
43MP0000377_abnormal_hair_follicle1.23582896
44MP0002822_catalepsy1.20541001
45MP0002896_abnormal_bone_mineralization1.14007343
46MP0003638_abnormal_response/metabolism_1.04801532
47MP0005410_abnormal_fertilization1.04131902
48MP0000613_abnormal_salivary_gland1.02081931
49MP0005075_abnormal_melanosome_morpholog0.96848405
50MP0001216_abnormal_epidermal_layer0.89828466
51MP0003693_abnormal_embryo_hatching0.88563029
52MP0001177_atelectasis0.86379954
53MP0001944_abnormal_pancreas_morphology0.85664361
54MP0002160_abnormal_reproductive_system0.84304105
55MP0002877_abnormal_melanocyte_morpholog0.82882969
56MP0008872_abnormal_physiological_respon0.75392191
57MP0002168_other_aberrant_phenotype0.75227445
58MP0008875_abnormal_xenobiotic_pharmacok0.73100712
59MP0002876_abnormal_thyroid_physiology0.72640644
60MP0001664_abnormal_digestion0.71131043
61MP0003868_abnormal_feces_composition0.70240673
62MP0001661_extended_life_span0.70231116
63MP0004019_abnormal_vitamin_homeostasis0.69361173
64MP0002653_abnormal_ependyma_morphology0.67059475
65MP0010329_abnormal_lipoprotein_level0.66804351
66MP0005647_abnormal_sex_gland0.65128502
67MP0001756_abnormal_urination0.64877540
68MP0002938_white_spotting0.63379922
69MP0009053_abnormal_anal_canal0.61610541
70MP0005365_abnormal_bile_salt0.61264310
71MP0004381_abnormal_hair_follicle0.60868137
72MP0005085_abnormal_gallbladder_physiolo0.60200852
73MP0000678_abnormal_parathyroid_gland0.58789047
74MP0005187_abnormal_penis_morphology0.57613401
75MP0005395_other_phenotype0.57280438
76MP0001929_abnormal_gametogenesis0.56801487
77MP0010030_abnormal_orbit_morphology0.56468615
78MP0000371_diluted_coat_color0.56193134
79MP0002693_abnormal_pancreas_physiology0.55787882
80MP0002090_abnormal_vision0.54609398
81MP0000653_abnormal_sex_gland0.53975974
82MP0010352_gastrointestinal_tract_polyps0.52907853
83MP0000367_abnormal_coat/_hair0.52655308
84MP0000647_abnormal_sebaceous_gland0.52327800
85MP0000467_abnormal_esophagus_morphology0.51893841
86MP0003195_calcinosis0.51674053
87MP0001145_abnormal_male_reproductive0.51586227
88MP0003698_abnormal_male_reproductive0.49835824
89MP0000538_abnormal_urinary_bladder0.49820356
90MP0001186_pigmentation_phenotype0.49192115
91MP0006276_abnormal_autonomic_nervous0.48171333
92MP0000762_abnormal_tongue_morphology0.47865283
93MP0010771_integument_phenotype0.47173281
94MP0005220_abnormal_exocrine_pancreas0.46966447
95MP0005058_abnormal_lysosome_morphology0.46748965
96MP0004147_increased_porphyrin_level0.45912944
97MP0005275_abnormal_skin_tensile0.44994705
98MP0003938_abnormal_ear_development0.44597680
99MP0005646_abnormal_pituitary_gland0.43953317
100MP0003699_abnormal_female_reproductive0.42072318

Predicted human phenotypes

RankGene SetZ-score
1Sparse lateral eyebrow (HP:0005338)7.20876816
2Concave nail (HP:0001598)6.87374853
3Oligomenorrhea (HP:0000876)6.22661283
4Abnormality of nail color (HP:0100643)5.30984840
5Abnormality of the proximal phalanges of the hand (HP:0009834)4.77362979
6Flat capital femoral epiphysis (HP:0003370)4.34009097
7Pili torti (HP:0003777)4.31765888
8Right ventricular cardiomyopathy (HP:0011663)3.91448575
9Testicular atrophy (HP:0000029)3.90960580
10Deep philtrum (HP:0002002)3.79784202
11Infertility (HP:0000789)3.72116079
12Curly hair (HP:0002212)3.67434463
13Ependymoma (HP:0002888)3.56795717
14Menorrhagia (HP:0000132)3.52409179
15Infantile muscular hypotonia (HP:0008947)3.49105123
16Lip pit (HP:0100267)3.26895310
17Flat acetabular roof (HP:0003180)3.04586596
18Exostoses (HP:0100777)3.01595411
19Tubulointerstitial nephritis (HP:0001970)3.00010794
20Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.94669584
21Spontaneous abortion (HP:0005268)2.86405011
22Astrocytoma (HP:0009592)2.84850690
23Abnormality of the astrocytes (HP:0100707)2.84850690
24Congenital ichthyosiform erythroderma (HP:0007431)2.77396305
25Septate vagina (HP:0001153)2.70239419
26Germ cell neoplasia (HP:0100728)2.62191801
27Abnormal tarsal ossification (HP:0008369)2.61945596
28Hyperglycinuria (HP:0003108)2.59651434
29Ectropion (HP:0000656)2.54289080
30Abnormality of the epiphyses of the hand (HP:0005924)2.54255374
31Hypoplastic labia majora (HP:0000059)2.54059025
32Partial duplication of thumb phalanx (HP:0009944)2.50136941
33Glioma (HP:0009733)2.49945949
34Abnormal hair laboratory examination (HP:0003328)2.44829868
35Azoospermia (HP:0000027)2.43478565
36Abnormality involving the epiphyses of the upper limbs (HP:0003839)2.40898080
37Back pain (HP:0003418)2.37887497
38Hyperkalemia (HP:0002153)2.34449058
39Abnormal cartilage morphology (HP:0002763)2.33812923
40Gonadotropin excess (HP:0000837)2.26501455
41Prostate neoplasm (HP:0100787)2.25356551
42Aplasia cutis congenita (HP:0001057)2.19421592
43Abnormality of the labia majora (HP:0012881)2.19376313
44Cystic liver disease (HP:0006706)2.14298612
45Abnormality of the phalanges of the hallux (HP:0010057)2.12415191
46Bifid scrotum (HP:0000048)2.11452625
47Amelogenesis imperfecta (HP:0000705)2.10045820
48Partial duplication of the phalanx of hand (HP:0009999)2.09742518
49Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.09577152
50Hypotension (HP:0002615)2.07729723
51Abnormality of the distal phalanges of the toes (HP:0010182)2.07715016
52Severe Myopia (HP:0011003)2.06490810
53Testicular neoplasm (HP:0010788)2.04747680
54Hyperammonemia (HP:0001987)2.01228192
55Abnormality of the dental root (HP:0006486)2.00843720
56Taurodontia (HP:0000679)2.00843720
57Abnormality of permanent molar morphology (HP:0011071)2.00843720
58Abnormality of serine family amino acid metabolism (HP:0010894)2.00016601
59Abnormality of glycine metabolism (HP:0010895)2.00016601
60Congenital glaucoma (HP:0001087)1.96701159
61Insidious onset (HP:0003587)1.96067683
62Termporal pattern (HP:0011008)1.96067683
63Abnormality of the renal cortex (HP:0011035)1.96011601
64Pulmonary artery stenosis (HP:0004415)1.94543926
65Cone-rod dystrophy (HP:0000548)1.93861661
66Abnormality of the parathyroid morphology (HP:0011766)1.93746094
67Abnormality of secondary sexual hair (HP:0009888)1.91698603
68Abnormality of the axillary hair (HP:0100134)1.91698603
69Epiphyseal stippling (HP:0010655)1.91502042
70Hypotrichosis (HP:0001006)1.91047081
71Short 1st metacarpal (HP:0010034)1.89942019
72Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.89942019
73Thin bony cortex (HP:0002753)1.89362179
74Capillary hemangiomas (HP:0005306)1.88315213
75Gout (HP:0001997)1.87916180
76Microretrognathia (HP:0000308)1.86839609
77Abnormality of molar (HP:0011077)1.85774818
78Abnormality of molar morphology (HP:0011070)1.85774818
79Renal salt wasting (HP:0000127)1.81726545
80Abnormality of hair growth rate (HP:0011363)1.80429189
81Slow-growing hair (HP:0002217)1.80429189
82Unilateral renal agenesis (HP:0000122)1.77349625
83Abnormality of the labia minora (HP:0012880)1.77091367
84Abdominal distention (HP:0003270)1.76519750
85Chronic sinusitis (HP:0011109)1.76160788
86Abnormal spermatogenesis (HP:0008669)1.75884159
87Abnormality of the dental pulp (HP:0006479)1.74975464
88Hypoplasia of dental enamel (HP:0006297)1.74934851
89Woolly hair (HP:0002224)1.72981421
90Abnormal foot bone ossification (HP:0010675)1.71565266
91Pigmentary retinal degeneration (HP:0001146)1.71307071
92Neonatal death (HP:0003811)1.70085441
93Bell-shaped thorax (HP:0001591)1.69098189
94Calf muscle hypertrophy (HP:0008981)1.65726459
95Hyperactive renin-angiotensin system (HP:0000841)1.63041105
96Progressive cerebellar ataxia (HP:0002073)1.61603586
97Birth length less than 3rd percentile (HP:0003561)1.60576397
98Sparse eyelashes (HP:0000653)1.58239392
99Autoamputation (HP:0001218)1.58094771
100Abnormality of the 1st metacarpal (HP:0010009)1.55890104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.32259977
2EIF2AK13.95011536
3FER3.54062808
4LATS13.13924405
5PKN22.98994959
6STK38L2.94928666
7TSSK62.83511268
8TNK22.67969515
9EPHA22.62361735
10TRIB32.51719204
11PNCK2.45889055
12MAPKAPK32.38272545
13AKT32.33362033
14MATK2.01434122
15EIF2AK31.98433194
16BRSK21.98394197
17WEE11.85386505
18FGFR41.84401958
19PRKCI1.74099357
20CDK71.69045843
21SIK11.63357210
22CDK121.61372568
23MET1.59444106
24MST41.50693043
25JAK21.48336994
26LIMK11.48233871
27MST1R1.46141053
28SCYL21.42919380
29LATS21.28467249
30RIPK11.25211591
31ERBB21.21331793
32NEK91.18935663
33STK391.17516716
34RPS6KB21.14877070
35INSRR0.98927990
36GRK60.95435606
37STK380.95350579
38TAF10.93096273
39PDGFRB0.92418885
40PRKAA20.90165120
41PBK0.88675481
42STK30.87187160
43EPHA30.85078926
44PTK20.84587643
45TAOK30.83899926
46CSNK1E0.80539167
47WNK40.80098475
48ERBB30.79269407
49EEF2K0.78193485
50PAK30.75222010
51MUSK0.73584272
52CASK0.73180434
53BMPR20.72527564
54ALK0.71745133
55YES10.69942073
56MAPK150.69517261
57LRRK20.65955365
58CHUK0.65527355
59BRSK10.63719964
60CAMK1D0.60692649
61SGK20.58648446
62MAP2K60.57199420
63FRK0.56552146
64AKT20.56544858
65MTOR0.56500183
66PTK60.55830114
67CAMK1G0.55350871
68TTK0.55051012
69MINK10.52991626
70DMPK0.52458021
71NUAK10.51286764
72CDK30.50365191
73RET0.49946998
74NEK60.48692544
75MAP3K30.48012559
76ZAP700.44368462
77PRKAA10.43794291
78NME10.41100632
79SGK30.40117088
80PRKD10.37145569
81PDGFRA0.36555196
82CSNK2A20.34794911
83HIPK20.34052557
84TESK20.33028105
85ILK0.32158690
86OXSR10.30711819
87SRPK10.30578193
88IGF1R0.30340888
89ATR0.29623604
90CSNK1A10.28302046
91SGK10.27070410
92MAPK80.25240474
93CDK10.24232023
94PAK20.23892670
95JAK10.23370200
96GSK3B0.23009043
97MAP2K10.22395051
98ERBB40.22280126
99MAPK100.21975256
100PAK40.21813499

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.88840708
2Protein export_Homo sapiens_hsa030603.16419819
3Butanoate metabolism_Homo sapiens_hsa006502.81708702
4* ABC transporters_Homo sapiens_hsa020102.79410508
5Phenylalanine metabolism_Homo sapiens_hsa003602.75512660
6Fatty acid elongation_Homo sapiens_hsa000622.63885620
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.55847020
8Fatty acid biosynthesis_Homo sapiens_hsa000612.52456995
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.50326007
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.25227276
11Sphingolipid metabolism_Homo sapiens_hsa006002.11522001
12Histidine metabolism_Homo sapiens_hsa003402.01864084
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.98202801
14beta-Alanine metabolism_Homo sapiens_hsa004101.97271783
15Fatty acid metabolism_Homo sapiens_hsa012121.92303438
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76813593
17Peroxisome_Homo sapiens_hsa041461.75290890
18Sulfur metabolism_Homo sapiens_hsa009201.73891277
19Mismatch repair_Homo sapiens_hsa034301.68837724
20Homologous recombination_Homo sapiens_hsa034401.68769573
21Tyrosine metabolism_Homo sapiens_hsa003501.65892264
22Prolactin signaling pathway_Homo sapiens_hsa049171.61954996
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53240166
24Non-homologous end-joining_Homo sapiens_hsa034501.51932319
25Fatty acid degradation_Homo sapiens_hsa000711.51544365
26N-Glycan biosynthesis_Homo sapiens_hsa005101.43785332
27Propanoate metabolism_Homo sapiens_hsa006401.40775976
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27816609
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27228522
30Caffeine metabolism_Homo sapiens_hsa002321.26871341
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26741657
32Chemical carcinogenesis_Homo sapiens_hsa052041.18947297
33Steroid biosynthesis_Homo sapiens_hsa001001.11032918
34Tryptophan metabolism_Homo sapiens_hsa003801.06721255
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05800895
36Prostate cancer_Homo sapiens_hsa052151.03688326
37One carbon pool by folate_Homo sapiens_hsa006701.02685563
38Fanconi anemia pathway_Homo sapiens_hsa034600.99437830
39Endometrial cancer_Homo sapiens_hsa052130.98311724
40Glutathione metabolism_Homo sapiens_hsa004800.95852694
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93762920
42Nucleotide excision repair_Homo sapiens_hsa034200.93448831
43Primary bile acid biosynthesis_Homo sapiens_hsa001200.90700789
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89956286
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.89081680
46Mineral absorption_Homo sapiens_hsa049780.88732202
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.87510304
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86871164
49Arginine and proline metabolism_Homo sapiens_hsa003300.86599400
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86379724
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.86212948
52AMPK signaling pathway_Homo sapiens_hsa041520.79745177
53Estrogen signaling pathway_Homo sapiens_hsa049150.79686760
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.79677873
55Circadian rhythm_Homo sapiens_hsa047100.79269149
56Bladder cancer_Homo sapiens_hsa052190.75227587
57Thyroid cancer_Homo sapiens_hsa052160.74395680
58Nitrogen metabolism_Homo sapiens_hsa009100.73630463
59PPAR signaling pathway_Homo sapiens_hsa033200.71774004
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54610551
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53315785
62RNA transport_Homo sapiens_hsa030130.53155309
63Starch and sucrose metabolism_Homo sapiens_hsa005000.49907772
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49452133
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48860164
66Metabolic pathways_Homo sapiens_hsa011000.48037119
67Pyruvate metabolism_Homo sapiens_hsa006200.47217474
68Endocytosis_Homo sapiens_hsa041440.46622580
69Arginine biosynthesis_Homo sapiens_hsa002200.46556370
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45488186
71Pancreatic cancer_Homo sapiens_hsa052120.45158160
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44121110
73Retinol metabolism_Homo sapiens_hsa008300.42550329
74Other glycan degradation_Homo sapiens_hsa005110.40266684
75Insulin resistance_Homo sapiens_hsa049310.37993504
76Lysosome_Homo sapiens_hsa041420.37924577
77mRNA surveillance pathway_Homo sapiens_hsa030150.36962770
78Glucagon signaling pathway_Homo sapiens_hsa049220.36720687
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36304188
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36275649
81Sulfur relay system_Homo sapiens_hsa041220.36269378
82Renin-angiotensin system_Homo sapiens_hsa046140.36188363
83Fructose and mannose metabolism_Homo sapiens_hsa000510.33171340
84Oocyte meiosis_Homo sapiens_hsa041140.33074894
85Glycosaminoglycan degradation_Homo sapiens_hsa005310.32868311
86Insulin signaling pathway_Homo sapiens_hsa049100.32192442
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.32147308
88DNA replication_Homo sapiens_hsa030300.30446365
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30027005
90Inositol phosphate metabolism_Homo sapiens_hsa005620.29092182
91ErbB signaling pathway_Homo sapiens_hsa040120.28005126
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27161399
93Biosynthesis of amino acids_Homo sapiens_hsa012300.25458602
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25237208
95Lysine degradation_Homo sapiens_hsa003100.25228410
96Jak-STAT signaling pathway_Homo sapiens_hsa046300.24756024
97Acute myeloid leukemia_Homo sapiens_hsa052210.24402893
98Hepatitis C_Homo sapiens_hsa051600.23760735
99mTOR signaling pathway_Homo sapiens_hsa041500.23015768
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22781210

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