ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-fucose catabolic process (GO:0042355)	4.42099002
2	fucose catabolic process (GO:0019317)	4.42099002
3	L-fucose metabolic process (GO:0042354)	4.42099002
4	indolalkylamine metabolic process (GO:0006586)	4.36950641
5	behavioral response to nicotine (GO:0035095)	4.27621530
6	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.89922988
7	signal peptide processing (GO:0006465)	3.69986592
8	tryptophan catabolic process (GO:0006569)	3.63367711
9	indole-containing compound catabolic process (GO:0042436)	3.63367711
10	indolalkylamine catabolic process (GO:0046218)	3.63367711
11	oxygen transport (GO:0015671)	3.59670184
12	protein K11-linked deubiquitination (GO:0035871)	3.58380071
13	tryptophan metabolic process (GO:0006568)	3.57049125
14	piRNA metabolic process (GO:0034587)	3.55126858
15	DNA deamination (GO:0045006)	3.46384272
16	cellular ketone body metabolic process (GO:0046950)	3.27916499
17	rRNA catabolic process (GO:0016075)	3.19656306
18	establishment of protein localization to Golgi (GO:0072600)	3.17270900
19	response to pheromone (GO:0019236)	3.17059357
20	kynurenine metabolic process (GO:0070189)	3.15103574
21	detection of light stimulus involved in visual perception (GO:0050908)	3.14761210
22	detection of light stimulus involved in sensory perception (GO:0050962)	3.14761210
23	autophagic vacuole fusion (GO:0000046)	3.14223872
24	sulfation (GO:0051923)	3.13683002
25	glycine transport (GO:0015816)	3.10808444
26	killing of cells of other organism (GO:0031640)	3.08369178
27	disruption of cells of other organism (GO:0044364)	3.08369178
28	organelle membrane fusion (GO:0090174)	3.06144767
29	auditory receptor cell stereocilium organization (GO:0060088)	3.05571832
30	protoporphyrinogen IX metabolic process (GO:0046501)	3.04167801
31	negative regulation of cAMP-mediated signaling (GO:0043951)	3.03878229
32	neural tube formation (GO:0001841)	3.00026332
33	photoreceptor cell maintenance (GO:0045494)	2.91945289
34	adaptation of signaling pathway (GO:0023058)	2.90346876
35	DNA methylation involved in gamete generation (GO:0043046)	2.87329702
36	thyroid hormone metabolic process (GO:0042403)	2.85491206
37	proline transport (GO:0015824)	2.85368233
38	ketone body metabolic process (GO:1902224)	2.85063636
39	indole-containing compound metabolic process (GO:0042430)	2.85023456
40	negative regulation of mast cell activation (GO:0033004)	2.83534673
41	gas transport (GO:0015669)	2.82700970
42	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.76143227
43	reflex (GO:0060004)	2.75687564
44	protein K48-linked deubiquitination (GO:0071108)	2.74102703
45	regulation of hippo signaling (GO:0035330)	2.72334068
46	platelet dense granule organization (GO:0060155)	2.70371790
47	protein K63-linked deubiquitination (GO:0070536)	2.70164611
48	negative regulation of interleukin-1 beta production (GO:0032691)	2.68384810
49	drug catabolic process (GO:0042737)	2.68172039
50	oxidative demethylation (GO:0070989)	2.67625060
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66151776
52	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.65897647
53	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.65897647
54	negative regulation of interleukin-1 production (GO:0032692)	2.64615414
55	gamma-aminobutyric acid transport (GO:0015812)	2.63556860
56	flavonoid metabolic process (GO:0009812)	2.63100746
57	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.62752815
58	DNA demethylation (GO:0080111)	2.60475359
59	positive regulation of fatty acid transport (GO:2000193)	2.60092771
60	protein targeting to Golgi (GO:0000042)	2.59778608
61	cytidine deamination (GO:0009972)	2.59429724
62	cytidine metabolic process (GO:0046087)	2.59429724
63	cytidine catabolic process (GO:0006216)	2.59429724
64	defense response to fungus (GO:0050832)	2.59315737
65	multicellular organism reproduction (GO:0032504)	2.58086221
66	retinal cone cell development (GO:0046549)	2.56873260
67	protoporphyrinogen IX biosynthetic process (GO:0006782)	2.56696491
68	leukotriene biosynthetic process (GO:0019370)	2.56096364
69	NAD biosynthetic process (GO:0009435)	2.54868902
70	alkaloid metabolic process (GO:0009820)	2.53843980
71	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.53713459
72	exogenous drug catabolic process (GO:0042738)	2.53630299
73	amine catabolic process (GO:0009310)	2.52475585
74	cellular biogenic amine catabolic process (GO:0042402)	2.52475585
75	regulation of B cell receptor signaling pathway (GO:0050855)	2.52175964
76	dopamine transport (GO:0015872)	2.52066515
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.49170794
78	positive regulation of granulocyte differentiation (GO:0030854)	2.47831715
79	regulation of triglyceride catabolic process (GO:0010896)	2.47715849
80	regulation of guanylate cyclase activity (GO:0031282)	2.47047483
81	axoneme assembly (GO:0035082)	2.45435892
82	bicarbonate transport (GO:0015701)	2.42293281
83	positive regulation of defense response to virus by host (GO:0002230)	2.40075943
84	kidney morphogenesis (GO:0060993)	2.38886098
85	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.38331160
86	cilium or flagellum-dependent cell motility (GO:0001539)	2.36838197
87	behavioral response to ethanol (GO:0048149)	2.35796973
88	S-adenosylmethionine metabolic process (GO:0046500)	2.35064549
89	hemoglobin metabolic process (GO:0020027)	2.33551843
90	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.32597329
91	amino acid salvage (GO:0043102)	2.31679114
92	L-methionine salvage (GO:0071267)	2.31679114
93	L-methionine biosynthetic process (GO:0071265)	2.31679114
94	hepatocyte apoptotic process (GO:0097284)	2.30716575
95	regulation of neurotransmitter uptake (GO:0051580)	2.30471896
96	positive regulation of prostaglandin secretion (GO:0032308)	2.30365723
97	negative regulation of telomere maintenance (GO:0032205)	2.29433180
98	tetrapyrrole biosynthetic process (GO:0033014)	2.28817236
99	positive regulation of guanylate cyclase activity (GO:0031284)	2.28422102
100	negative regulation of execution phase of apoptosis (GO:1900118)	2.28393765

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.34117231
2	VDR_22108803_ChIP-Seq_LS180_Human	3.08240536
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.81483580
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.81407746
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.63301194
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.42117542
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.34194746
8	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.25350570
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.20645923
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18567018
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02391142
12	ER_23166858_ChIP-Seq_MCF-7_Human	1.95015758
13	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.92845267
14	P300_19829295_ChIP-Seq_ESCs_Human	1.91542985
15	GATA1_22025678_ChIP-Seq_K562_Human	1.87440977
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.85079001
17	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72503204
18	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.71685967
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69520142
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.68184148
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.64861651
22	BCAT_22108803_ChIP-Seq_LS180_Human	1.64826187
23	TP53_22573176_ChIP-Seq_HFKS_Human	1.63889377
24	EWS_26573619_Chip-Seq_HEK293_Human	1.61717318
25	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.59652265
26	STAT3_23295773_ChIP-Seq_U87_Human	1.59066694
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59030374
28	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.52899350
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.50832790
30	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.49983021
31	TCF4_23295773_ChIP-Seq_U87_Human	1.44962148
32	FUS_26573619_Chip-Seq_HEK293_Human	1.44261608
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.43389046
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42240855
35	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.41972060
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.40111610
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40111610
38	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.39523782
39	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.38059655
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.37992766
41	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37465693
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.37187964
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.36473312
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.36344939
45	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.36344939
46	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.35994028
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35115400
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.34932888
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.34932888
50	SMAD4_21799915_ChIP-Seq_A2780_Human	1.34729124
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34077071
52	IRF1_19129219_ChIP-ChIP_H3396_Human	1.31934625
53	AR_25329375_ChIP-Seq_VCAP_Human	1.31658810
54	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.31535702
55	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.29996811
56	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29659757
57	CDX2_22108803_ChIP-Seq_LS180_Human	1.29016247
58	EZH2_22144423_ChIP-Seq_EOC_Human	1.26935369
59	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.25391679
60	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.25387989
61	AR_20517297_ChIP-Seq_VCAP_Human	1.24175441
62	GATA3_26560356_Chip-Seq_TH2_Human	1.23699375
63	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22875361
64	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.22645352
65	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22563459
66	NCOR_22424771_ChIP-Seq_293T_Human	1.21928633
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.20713854
68	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.19156440
69	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.18036409
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.16392393
71	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15365180
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.15100945
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.14772583
74	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.13431074
75	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12991041
76	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.12903490
77	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.12710020
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10703262
79	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.10666390
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.10023377
81	* PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07617295
82	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06920679
83	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.06867306
84	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.06867306
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.06839456
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.05511103
87	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.04845724
88	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04803252
89	SCL_19346495_ChIP-Seq_HPC-7_Human	1.04738181
90	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.04736890
91	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.04619624
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.02954321
93	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01939699
94	AR_21572438_ChIP-Seq_LNCaP_Human	1.01276550
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.00944207
96	SMRT_27268052_Chip-Seq_Bcells_Human	1.00889428
97	REST_21632747_ChIP-Seq_MESCs_Mouse	1.00807748
98	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.99376901
99	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.99028072
100	GATA1_19941826_ChIP-Seq_K562_Human	0.98975190

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004147_increased_porphyrin_level	4.83760071
2	MP0003195_calcinosis	3.88696028
3	MP0005360_urolithiasis	2.68180928
4	MP0008877_abnormal_DNA_methylation	2.66355668
5	MP0000569_abnormal_digit_pigmentation	2.49802216
6	MP0002876_abnormal_thyroid_physiology	2.49087486
7	MP0001501_abnormal_sleep_pattern	2.36294165
8	MP0008872_abnormal_physiological_respon	2.20498184
9	MP0004043_abnormal_pH_regulation	2.18441044
10	MP0005085_abnormal_gallbladder_physiolo	2.10468089
11	MP0003656_abnormal_erythrocyte_physiolo	2.04501260
12	MP0005671_abnormal_response_to	1.92086494
13	MP0003183_abnormal_peptide_metabolism	1.91382867
14	MP0005551_abnormal_eye_electrophysiolog	1.90453717
15	MP0005083_abnormal_biliary_tract	1.85810342
16	MP0002102_abnormal_ear_morphology	1.82536024
17	MP0005174_abnormal_tail_pigmentation	1.82071678
18	MP0001968_abnormal_touch/_nociception	1.74541788
19	MP0005645_abnormal_hypothalamus_physiol	1.59677211
20	MP0008875_abnormal_xenobiotic_pharmacok	1.59538863
21	MP0002736_abnormal_nociception_after	1.59485630
22	MP0003878_abnormal_ear_physiology	1.56506493
23	MP0005377_hearing/vestibular/ear_phenot	1.56506493
24	MP0000427_abnormal_hair_cycle	1.50129503
25	MP0003787_abnormal_imprinting	1.47770864
26	MP0003724_increased_susceptibility_to	1.47457462
27	MP0008995_early_reproductive_senescence	1.43143604
28	MP0000015_abnormal_ear_pigmentation	1.40803511
29	MP0005075_abnormal_melanosome_morpholog	1.38488659
30	MP0001986_abnormal_taste_sensitivity	1.38001721
31	MP0009046_muscle_twitch	1.34853761
32	MP0003252_abnormal_bile_duct	1.33154918
33	MP0005636_abnormal_mineral_homeostasis	1.32635541
34	MP0009764_decreased_sensitivity_to	1.30935625
35	MP0003866_abnormal_defecation	1.28681342
36	MP0005365_abnormal_bile_salt	1.28334595
37	MP0004885_abnormal_endolymph	1.28304660
38	MP0010329_abnormal_lipoprotein_level	1.26283808
39	MP0004742_abnormal_vestibular_system	1.26174275
40	MP0006276_abnormal_autonomic_nervous	1.25280980
41	MP0004142_abnormal_muscle_tone	1.24466207
42	MP0009745_abnormal_behavioral_response	1.22654454
43	MP0002095_abnormal_skin_pigmentation	1.22305740
44	MP0003646_muscle_fatigue	1.21331757
45	MP0001835_abnormal_antigen_presentation	1.21193307
46	MP0009785_altered_susceptibility_to	1.20967903
47	MP0000685_abnormal_immune_system	1.20637749
48	MP0005332_abnormal_amino_acid	1.17043836
49	MP0005253_abnormal_eye_physiology	1.16643786
50	MP0002138_abnormal_hepatobiliary_system	1.14976574
51	MP0000538_abnormal_urinary_bladder	1.12528983
52	MP0001664_abnormal_digestion	1.11466027
53	MP0002148_abnormal_hypersensitivity_rea	1.10688077
54	MP0005310_abnormal_salivary_gland	1.10367808
55	MP0001905_abnormal_dopamine_level	1.09073986
56	MP0001800_abnormal_humoral_immune	1.08971258
57	MP0003011_delayed_dark_adaptation	1.08923771
58	MP0001765_abnormal_ion_homeostasis	1.08060752
59	MP0002653_abnormal_ependyma_morphology	1.07258850
60	MP0010155_abnormal_intestine_physiology	1.01690650
61	MP0001485_abnormal_pinna_reflex	0.99442605
62	MP0000372_irregular_coat_pigmentation	0.99132514
63	MP0002837_dystrophic_cardiac_calcinosis	0.98222357
64	MP0000230_abnormal_systemic_arterial	0.96221010
65	MP0005387_immune_system_phenotype	0.95588016
66	MP0001790_abnormal_immune_system	0.95588016
67	MP0005167_abnormal_blood-brain_barrier	0.95164035
68	MP0009643_abnormal_urine_homeostasis	0.94058209
69	MP0002723_abnormal_immune_serum	0.92739176
70	MP0002254_reproductive_system_inflammat	0.92470160
71	MP0006054_spinal_hemorrhage	0.91006247
72	MP0002229_neurodegeneration	0.89133565
73	MP0002272_abnormal_nervous_system	0.88941385
74	MP0004019_abnormal_vitamin_homeostasis	0.86350883
75	MP0006072_abnormal_retinal_apoptosis	0.86169606
76	MP0001756_abnormal_urination	0.85019874
77	MP0005646_abnormal_pituitary_gland	0.84515201
78	MP0001486_abnormal_startle_reflex	0.82546387
79	MP0002733_abnormal_thermal_nociception	0.81892708
80	MP0001970_abnormal_pain_threshold	0.81864266
81	MP0005266_abnormal_metabolism	0.81542846
82	MP0003718_maternal_effect	0.80869327
83	MP0006036_abnormal_mitochondrial_physio	0.80703200
84	MP0002420_abnormal_adaptive_immunity	0.80352009
85	MP0005084_abnormal_gallbladder_morpholo	0.80196596
86	MP0001819_abnormal_immune_cell	0.79965787
87	MP0002693_abnormal_pancreas_physiology	0.78661124
88	MP0003045_fibrosis	0.77923784
89	MP0001873_stomach_inflammation	0.77355549
90	MP0005171_absent_coat_pigmentation	0.76453471
91	MP0005410_abnormal_fertilization	0.75745188
92	MP0003786_premature_aging	0.75320062
93	MP0003698_abnormal_male_reproductive	0.74375638
94	MP0000689_abnormal_spleen_morphology	0.74133710
95	MP0002452_abnormal_antigen_presenting	0.72734695
96	MP0001764_abnormal_homeostasis	0.72539008
97	MP0001845_abnormal_inflammatory_respons	0.72517989
98	MP0002136_abnormal_kidney_physiology	0.71911834
99	MP0005448_abnormal_energy_balance	0.71810811
100	MP0003136_yellow_coat_color	0.71380200

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.02932396
2	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.75205548
3	Hypochromic microcytic anemia (HP:0004840)	3.72080514
4	Pancreatic fibrosis (HP:0100732)	3.54222302
5	True hermaphroditism (HP:0010459)	3.42687355
6	Abnormality of the renal cortex (HP:0011035)	3.25854930
7	Attenuation of retinal blood vessels (HP:0007843)	3.17942294
8	Abolished electroretinogram (ERG) (HP:0000550)	3.12369050
9	Congenital stationary night blindness (HP:0007642)	3.08608375
10	Stomatitis (HP:0010280)	2.89905096
11	Hyperventilation (HP:0002883)	2.88986276
12	Thyroiditis (HP:0100646)	2.87370858
13	Renal cortical cysts (HP:0000803)	2.84186809
14	Abnormality of B cell number (HP:0010975)	2.81084594
15	Gaze-evoked nystagmus (HP:0000640)	2.75476822
16	Hypoproteinemia (HP:0003075)	2.71452679
17	Congenital sensorineural hearing impairment (HP:0008527)	2.69316010
18	Poikilocytosis (HP:0004447)	2.67217568
19	Abnormality of midbrain morphology (HP:0002418)	2.65555452
20	Molar tooth sign on MRI (HP:0002419)	2.65555452
21	Hypothermia (HP:0002045)	2.60068741
22	Absent speech (HP:0001344)	2.55148883
23	Severe combined immunodeficiency (HP:0004430)	2.51774633
24	Type II lissencephaly (HP:0007260)	2.51249732
25	Nephronophthisis (HP:0000090)	2.50768342
26	Abnormality of vitamin B metabolism (HP:0004340)	2.48436959
27	Large for gestational age (HP:0001520)	2.45735443
28	Hypochromic anemia (HP:0001931)	2.43709277
29	Increased neuronal autofluorescent lipopigment (HP:0002074)	2.42105324
30	Medial flaring of the eyebrow (HP:0010747)	2.41068826
31	Progressive inability to walk (HP:0002505)	2.40111617
32	Cystic liver disease (HP:0006706)	2.38257765
33	Abnormality of the renal medulla (HP:0100957)	2.34532631
34	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.34268766
35	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.32298146
36	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.31930985
37	Decreased circulating renin level (HP:0003351)	2.31681898
38	Genetic anticipation (HP:0003743)	2.30255186
39	B lymphocytopenia (HP:0010976)	2.28381039
40	Clumsiness (HP:0002312)	2.25329353
41	IgG deficiency (HP:0004315)	2.23986282
42	Inability to walk (HP:0002540)	2.20118966
43	Abnormality of T cell number (HP:0011839)	2.20104832
44	Metabolic alkalosis (HP:0200114)	2.19570495
45	Panhypogammaglobulinemia (HP:0003139)	2.19231433
46	Furrowed tongue (HP:0000221)	2.18524352
47	Microcytic anemia (HP:0001935)	2.14885873
48	Keratoconus (HP:0000563)	2.12623766
49	Increased corneal curvature (HP:0100692)	2.12623766
50	Protruding tongue (HP:0010808)	2.11238522
51	Pendular nystagmus (HP:0012043)	2.07912145
52	Abnormality of eosinophils (HP:0001879)	2.07906290
53	Hypoplasia of the pons (HP:0012110)	2.06544281
54	Abnormal rod and cone electroretinograms (HP:0008323)	2.05335182
55	Ileus (HP:0002595)	2.03482257
56	Stomach cancer (HP:0012126)	2.03342568
57	Methylmalonic aciduria (HP:0012120)	2.01997255
58	Chronic hepatic failure (HP:0100626)	2.01671735
59	T lymphocytopenia (HP:0005403)	1.98634994
60	Eosinophilia (HP:0001880)	1.98266447
61	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.97091885
62	Methylmalonic acidemia (HP:0002912)	1.96809642
63	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.96707943
64	Decreased central vision (HP:0007663)	1.96318937
65	Tubular atrophy (HP:0000092)	1.95598818
66	Chronic diarrhea (HP:0002028)	1.94435067
67	Progressive cerebellar ataxia (HP:0002073)	1.94162268
68	Abnormality of the pons (HP:0007361)	1.91988795
69	Sclerocornea (HP:0000647)	1.91297138
70	Albinism (HP:0001022)	1.90684519
71	Lissencephaly (HP:0001339)	1.89118675
72	Abnormal drinking behavior (HP:0030082)	1.88363215
73	Polydipsia (HP:0001959)	1.88363215
74	Ketoacidosis (HP:0001993)	1.87885983
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.87796827
76	Fair hair (HP:0002286)	1.85520453
77	Constricted visual fields (HP:0001133)	1.84909378
78	Abnormality of proline metabolism (HP:0010907)	1.83528055
79	Hydroxyprolinuria (HP:0003080)	1.83528055
80	Congenital hepatic fibrosis (HP:0002612)	1.83019211
81	Ketosis (HP:0001946)	1.82349734
82	Polyuria (HP:0000103)	1.82141394
83	Anencephaly (HP:0002323)	1.81548313
84	Cerebellar dysplasia (HP:0007033)	1.81503922
85	Nephrogenic diabetes insipidus (HP:0009806)	1.80179258
86	Congenital primary aphakia (HP:0007707)	1.79986663
87	Abnormality of macular pigmentation (HP:0008002)	1.77687132
88	Gait imbalance (HP:0002141)	1.77679343
89	Abnormal biliary tract physiology (HP:0012439)	1.74836671
90	Bile duct proliferation (HP:0001408)	1.74836671
91	Hypoplasia of the thymus (HP:0000778)	1.74414261
92	Abnormality of alanine metabolism (HP:0010916)	1.74316523
93	Hyperalaninemia (HP:0003348)	1.74316523
94	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.74316523
95	Bony spicule pigmentary retinopathy (HP:0007737)	1.74306103
96	Abnormality of T cells (HP:0002843)	1.73629334
97	Combined immunodeficiency (HP:0005387)	1.72741283
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.72244578
99	Increased cerebral lipofuscin (HP:0011813)	1.69573301
100	Retrobulbar optic neuritis (HP:0100654)	1.68836114

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.74414313
2	ACVR1B	3.41638531
3	TXK	3.14017974
4	ADRBK2	3.04892865
5	TAOK3	2.99433637
6	NUAK1	2.72282038
7	BMPR1B	2.37343619
8	GRK1	2.36312512
9	ZAK	2.28130821
10	PINK1	2.23047097
11	WNK3	2.05863442
12	GRK6	1.68799393
13	INSRR	1.66994416
14	MAPK13	1.54064840
15	OXSR1	1.53880418
16	MAP4K2	1.53056869
17	PTK2B	1.40776023
18	TLK1	1.35957826
19	MAP4K1	1.32116546
20	TEC	1.30217601
21	ADRBK1	1.29426144
22	DAPK2	1.21695859
23	FES	1.19573882
24	SYK	1.18759533
25	IKBKB	1.17528255
26	MST4	1.14738702
27	EIF2AK1	1.08138128
28	CASK	1.08134445
29	MAP3K4	1.06762684
30	CAMKK2	1.06011396
31	IKBKE	0.97555611
32	MAP2K6	0.96572514
33	PAK3	0.96321893
34	PLK2	0.90945301
35	TNK2	0.89869915
36	STK39	0.84898737
37	PIK3CG	0.82907691
38	IRAK1	0.80373332
39	WNK4	0.79728551
40	PRKAA2	0.78778670
41	PRKCE	0.77014495
42	CCNB1	0.74560199
43	ITK	0.73239725
44	GRK5	0.72571734
45	NTRK3	0.70762915
46	TAOK1	0.69024343
47	LYN	0.69014039
48	PIM1	0.67504861
49	MKNK2	0.66939093
50	KIT	0.66119454
51	CHUK	0.63103950
52	BCKDK	0.63049981
53	PLK3	0.62550550
54	STK11	0.61660076
55	PRKCQ	0.56979847
56	BTK	0.56160909
57	ERBB2	0.56105780
58	FER	0.55613922
59	LCK	0.55409147
60	TIE1	0.54311548
61	MAP3K7	0.53710419
62	RPS6KA5	0.53020469
63	PHKG2	0.51377606
64	PHKG1	0.51377606
65	PIK3CA	0.49472907
66	EPHA3	0.48782812
67	MARK3	0.47440088
68	MAP2K2	0.47187106
69	CDK19	0.46182913
70	HCK	0.45344989
71	BMPR2	0.45032537
72	TGFBR1	0.44995597
73	ERBB3	0.44690175
74	MAP3K14	0.43327048
75	CLK1	0.43278458
76	MAPKAPK3	0.39504084
77	CAMK1D	0.39412178
78	PRKCG	0.38368367
79	TRPM7	0.37655733
80	PRKACA	0.37038268
81	EIF2AK3	0.36688313
82	PRKCA	0.36568930
83	STK38L	0.36530378
84	CAMK2A	0.36189899
85	MATK	0.35822074
86	STK3	0.34850015
87	GRK7	0.34200875
88	BCR	0.33617953
89	JAK3	0.33493310
90	IRAK4	0.33376388
91	TESK2	0.33015240
92	PRKCZ	0.32779570
93	AKT3	0.31931594
94	CAMK4	0.31673999
95	ABL1	0.31486879
96	PRKAA1	0.31304672
97	VRK1	0.29762841
98	IGF1R	0.29524127
99	CAMK1	0.28957212
100	FGFR2	0.27957435

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.92344104
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.73063933
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.72289499
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.53981202
5	Caffeine metabolism_Homo sapiens_hsa00232	2.53323966
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.51250263
7	Butanoate metabolism_Homo sapiens_hsa00650	2.49596508
8	Cyanoamino acid metabolism_Homo sapiens_hsa00460	2.37014622
9	Tryptophan metabolism_Homo sapiens_hsa00380	2.20255868
10	Phototransduction_Homo sapiens_hsa04744	2.19715809
11	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.08507495
12	Ether lipid metabolism_Homo sapiens_hsa00565	2.05813817
13	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.97502939
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.94988256
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.93740933
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.91006752
17	ABC transporters_Homo sapiens_hsa02010	1.85165055
18	Primary immunodeficiency_Homo sapiens_hsa05340	1.80782199
19	Sulfur metabolism_Homo sapiens_hsa00920	1.67366102
20	Fat digestion and absorption_Homo sapiens_hsa04975	1.65168726
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.63623582
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.54628121
23	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.52683158
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.48766806
25	Nicotine addiction_Homo sapiens_hsa05033	1.44508927
26	Mineral absorption_Homo sapiens_hsa04978	1.43970435
27	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.43663382
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.42178900
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.39283749
30	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.37924036
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.35718602
32	Glycerolipid metabolism_Homo sapiens_hsa00561	1.35102600
33	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.33704537
34	Retinol metabolism_Homo sapiens_hsa00830	1.32413652
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.31186380
36	Homologous recombination_Homo sapiens_hsa03440	1.29803128
37	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27859431
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.27266288
39	Collecting duct acid secretion_Homo sapiens_hsa04966	1.26060577
40	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.25189686
41	Peroxisome_Homo sapiens_hsa04146	1.19371905
42	Regulation of autophagy_Homo sapiens_hsa04140	1.09095129
43	Asthma_Homo sapiens_hsa05310	1.08387012
44	Olfactory transduction_Homo sapiens_hsa04740	1.04797549
45	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.02552443
46	Graft-versus-host disease_Homo sapiens_hsa05332	1.02063179
47	Propanoate metabolism_Homo sapiens_hsa00640	1.01640297
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.99528186
49	Taste transduction_Homo sapiens_hsa04742	0.97599631
50	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.96396673
51	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96235821
52	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.95969480
53	Histidine metabolism_Homo sapiens_hsa00340	0.94707013
54	Renin-angiotensin system_Homo sapiens_hsa04614	0.93136211
55	Morphine addiction_Homo sapiens_hsa05032	0.91548312
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.91375267
57	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90354212
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.86178115
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83284603
60	Serotonergic synapse_Homo sapiens_hsa04726	0.81530704
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81183863
62	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.80733259
63	Fatty acid degradation_Homo sapiens_hsa00071	0.79728653
64	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.73302207
65	Allograft rejection_Homo sapiens_hsa05330	0.71929665
66	Protein export_Homo sapiens_hsa03060	0.66671955
67	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.66098155
68	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65955496
69	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65030077
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.64442574
71	Insulin secretion_Homo sapiens_hsa04911	0.64348192
72	Salivary secretion_Homo sapiens_hsa04970	0.63502302
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62936161
74	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.62464769
75	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.58742192
76	GABAergic synapse_Homo sapiens_hsa04727	0.58414964
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57856268
78	African trypanosomiasis_Homo sapiens_hsa05143	0.57481487
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55231049
80	Fatty acid metabolism_Homo sapiens_hsa01212	0.52181133
81	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51523284
82	Circadian entrainment_Homo sapiens_hsa04713	0.48469044
83	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.48319222
84	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47370500
85	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.46217255
86	Metabolic pathways_Homo sapiens_hsa01100	0.46126290
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.45108903
88	Bile secretion_Homo sapiens_hsa04976	0.42896450
89	Rheumatoid arthritis_Homo sapiens_hsa05323	0.41318195
90	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.38731068
91	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38172442
92	Purine metabolism_Homo sapiens_hsa00230	0.37812219
93	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37466987
94	Malaria_Homo sapiens_hsa05144	0.36534169
95	PPAR signaling pathway_Homo sapiens_hsa03320	0.36486296
96	Basal transcription factors_Homo sapiens_hsa03022	0.36417899
97	Oxidative phosphorylation_Homo sapiens_hsa00190	0.34906987
98	Calcium signaling pathway_Homo sapiens_hsa04020	0.34442421
99	Long-term depression_Homo sapiens_hsa04730	0.32486551
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.29785409

ABCC13

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »