ABCC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.34882822
2L-phenylalanine catabolic process (GO:0006559)7.34882822
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.01909238
4L-phenylalanine metabolic process (GO:0006558)7.01909238
5polyketide metabolic process (GO:0030638)6.97264499
6doxorubicin metabolic process (GO:0044598)6.97264499
7daunorubicin metabolic process (GO:0044597)6.97264499
8aromatic amino acid family catabolic process (GO:0009074)6.67399932
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.26816350
10aminoglycoside antibiotic metabolic process (GO:0030647)6.18124098
11indole-containing compound catabolic process (GO:0042436)6.09007898
12indolalkylamine catabolic process (GO:0046218)6.09007898
13tryptophan catabolic process (GO:0006569)6.09007898
14kynurenine metabolic process (GO:0070189)5.91718692
15bile acid biosynthetic process (GO:0006699)5.79058949
16glyoxylate metabolic process (GO:0046487)5.73046119
17tryptophan metabolic process (GO:0006568)5.72918407
18urea cycle (GO:0000050)5.62204057
19urea metabolic process (GO:0019627)5.62204057
20alpha-linolenic acid metabolic process (GO:0036109)5.56828602
21cysteine metabolic process (GO:0006534)5.44241516
22high-density lipoprotein particle remodeling (GO:0034375)5.35914285
23negative regulation of fibrinolysis (GO:0051918)5.22397433
24nitrogen cycle metabolic process (GO:0071941)5.16334737
25regulation of plasminogen activation (GO:0010755)5.12920183
26sulfur amino acid catabolic process (GO:0000098)5.12846084
27complement activation, alternative pathway (GO:0006957)5.08121854
28regulation of protein activation cascade (GO:2000257)5.06958854
29protein carboxylation (GO:0018214)5.06124533
30peptidyl-glutamic acid carboxylation (GO:0017187)5.06124533
31regulation of fibrinolysis (GO:0051917)5.03208582
32fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.02487092
33serine family amino acid catabolic process (GO:0009071)5.01548214
34bile acid metabolic process (GO:0008206)4.97980269
35homocysteine metabolic process (GO:0050667)4.97453680
36regulation of triglyceride catabolic process (GO:0010896)4.87623716
37regulation of apoptotic cell clearance (GO:2000425)4.87311784
38negative regulation of protein activation cascade (GO:2000258)4.87302511
39aromatic amino acid family metabolic process (GO:0009072)4.84030499
40regulation of cholesterol esterification (GO:0010872)4.83650521
41lysine catabolic process (GO:0006554)4.81541935
42lysine metabolic process (GO:0006553)4.81541935
43reverse cholesterol transport (GO:0043691)4.75251004
44regulation of complement activation (GO:0030449)4.74522027
45plasma lipoprotein particle remodeling (GO:0034369)4.66547571
46protein-lipid complex remodeling (GO:0034368)4.66547571
47macromolecular complex remodeling (GO:0034367)4.66547571
48amino-acid betaine metabolic process (GO:0006577)4.65757160
49epoxygenase P450 pathway (GO:0019373)4.65259634
50negative regulation of sterol transport (GO:0032372)4.64336010
51negative regulation of cholesterol transport (GO:0032375)4.64336010
52phospholipid efflux (GO:0033700)4.60245320
53tyrosine metabolic process (GO:0006570)4.59967656
54alpha-amino acid catabolic process (GO:1901606)4.55696823
55intestinal absorption (GO:0050892)4.54456522
56acylglycerol homeostasis (GO:0055090)4.54205501
57triglyceride homeostasis (GO:0070328)4.54205501
58drug catabolic process (GO:0042737)4.50660843
59primary alcohol catabolic process (GO:0034310)4.50362200
60positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.46337602
61protein-lipid complex subunit organization (GO:0071825)4.46113172
62bile acid and bile salt transport (GO:0015721)4.42064227
63cellular ketone body metabolic process (GO:0046950)4.33312618
64cellular glucuronidation (GO:0052695)4.33272309
65indolalkylamine metabolic process (GO:0006586)4.31953980
66cholesterol efflux (GO:0033344)4.30393129
67glycine metabolic process (GO:0006544)4.25994104
68glutamate metabolic process (GO:0006536)4.25077371
69plasma lipoprotein particle clearance (GO:0034381)4.21830223
70coenzyme catabolic process (GO:0009109)4.21616464
71negative regulation of hemostasis (GO:1900047)4.21276843
72negative regulation of blood coagulation (GO:0030195)4.21276843
73cellular amino acid catabolic process (GO:0009063)4.20252048
74amine catabolic process (GO:0009310)4.19983188
75cellular biogenic amine catabolic process (GO:0042402)4.19983188
76serine family amino acid metabolic process (GO:0009069)4.17643626
77benzene-containing compound metabolic process (GO:0042537)4.13774504
78imidazole-containing compound metabolic process (GO:0052803)4.12285297
79regulation of humoral immune response (GO:0002920)4.11599726
80plasma lipoprotein particle assembly (GO:0034377)4.10718546
81acute-phase response (GO:0006953)4.10695576
82protein activation cascade (GO:0072376)4.08754539
83cellular modified amino acid catabolic process (GO:0042219)4.08308295
84intestinal cholesterol absorption (GO:0030299)4.04486827
85ethanol oxidation (GO:0006069)4.02491510
86regulation of bile acid biosynthetic process (GO:0070857)3.99140282
87serine family amino acid biosynthetic process (GO:0009070)3.98463452
88dicarboxylic acid biosynthetic process (GO:0043650)3.96494704
89omega-hydroxylase P450 pathway (GO:0097267)3.95164340
90positive regulation of hemostasis (GO:1900048)3.94635701
91positive regulation of blood coagulation (GO:0030194)3.94635701
92positive regulation of triglyceride lipase activity (GO:0061365)3.90216575
93positive regulation of lipoprotein lipase activity (GO:0051006)3.90216575
94arginine metabolic process (GO:0006525)3.89726470
95very-low-density lipoprotein particle assembly (GO:0034379)3.89593808
96negative regulation of coagulation (GO:0050819)3.89345886
97glucuronate metabolic process (GO:0019585)3.87581089
98uronic acid metabolic process (GO:0006063)3.87581089
99negative regulation of lipase activity (GO:0060192)3.86971732
100cholesterol homeostasis (GO:0042632)3.86547257
101proline metabolic process (GO:0006560)3.86061857
102negative regulation of complement activation (GO:0045916)3.84060003
103aldehyde catabolic process (GO:0046185)3.83980734
104exogenous drug catabolic process (GO:0042738)3.83760432
105low-density lipoprotein particle remodeling (GO:0034374)3.83391137
106regulation of cholesterol homeostasis (GO:2000188)3.82656415
107sterol homeostasis (GO:0055092)3.81269122
108phospholipid homeostasis (GO:0055091)3.79679296
109regulation of cholesterol biosynthetic process (GO:0045540)3.78140631
110flavonoid metabolic process (GO:0009812)3.77195023
111fibrinolysis (GO:0042730)3.77044357
112urate metabolic process (GO:0046415)3.76596775
113positive regulation of lipid catabolic process (GO:0050996)3.76427693
114complement activation, classical pathway (GO:0006958)3.75757118
115negative regulation of wound healing (GO:0061045)3.75423799
116ethanol metabolic process (GO:0006067)3.75219389
117ketone body metabolic process (GO:1902224)3.74561759
118short-chain fatty acid metabolic process (GO:0046459)3.72125880
119acetyl-CoA metabolic process (GO:0006084)3.71301902
120organic acid catabolic process (GO:0016054)3.70634837
121carboxylic acid catabolic process (GO:0046395)3.70634837
122glycoside metabolic process (GO:0016137)3.70624399
123protein-lipid complex assembly (GO:0065005)3.70387126
124response to nitrosative stress (GO:0051409)3.61825996
125positive regulation of coagulation (GO:0050820)3.61104099
126cofactor catabolic process (GO:0051187)3.60848303
127lipoprotein metabolic process (GO:0042157)3.60357830
128plasma lipoprotein particle organization (GO:0071827)3.60233516
129cholesterol transport (GO:0030301)3.56566367
130sterol transport (GO:0015918)3.56566367
131drug metabolic process (GO:0017144)3.56283093
132blood coagulation, intrinsic pathway (GO:0007597)3.55089310
133positive regulation of fatty acid biosynthetic process (GO:0045723)3.45246949
134positive regulation of extracellular matrix organization (GO:1903055)3.42475261
135complement activation (GO:0006956)3.38732800
136regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.37049260
137cytolysis (GO:0019835)3.30014550
138progesterone metabolic process (GO:0042448)3.22264768
139low-density lipoprotein particle clearance (GO:0034383)3.19802003

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.27848460
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.13119016
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.83544259
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.48037445
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.16509418
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.88268451
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.67949454
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.02531390
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83634796
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.26031872
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.14999986
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07869144
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7160435
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92940542
15AR_21909140_ChIP-Seq_LNCAP_Human1.81080155
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.73108858
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65810496
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59789066
19CLOCK_20551151_ChIP-Seq_293T_Human1.59550611
20HIF1A_21447827_ChIP-Seq_MCF-7_Human1.54348886
21GATA1_22025678_ChIP-Seq_K562_Human1.51692771
22* HNF4A_19822575_ChIP-Seq_HepG2_Human1.48983541
23HTT_18923047_ChIP-ChIP_STHdh_Human1.48299315
24TCF4_18268006_ChIP-ChIP_LS174T_Human1.41456592
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28418832
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.24253682
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20341806
28TRIM28_21343339_ChIP-Seq_HEK293_Human1.18177542
29* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14850715
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14411811
31RXRA_24833708_ChIP-Seq_LIVER_Mouse1.14025834
32TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13922954
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06687597
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06520042
35CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05672334
36* GATA4_25053715_ChIP-Seq_YYC3_Human0.99900344
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96788852
38GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.96137074
39ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95442609
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88980906
41PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86134540
42IRF8_22096565_ChIP-ChIP_GC-B_Human0.85751816
43CDX2_20551321_ChIP-Seq_CACO-2_Human0.85469303
44BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84390440
45RARG_19884340_ChIP-ChIP_MEFs_Mouse0.83699228
46SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.80233662
47AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80121398
48ESR2_21235772_ChIP-Seq_MCF-7_Human0.79826764
49ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.78997127
50KAP1_22055183_ChIP-Seq_ESCs_Mouse0.78701616
51* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77412994
52* ATF3_27146783_Chip-Seq_COLON_Human0.76619267
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76285935
54SALL4_18804426_ChIP-ChIP_XEN_Mouse0.75611719
55SOX17_20123909_ChIP-Seq_XEN_Mouse0.75603549
56STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.75239113
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74001320
58RARA_24833708_ChIP-Seq_LIVER_Mouse0.73159492
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72917406
60SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.72351008
61ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.72093954
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71654754
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.71357935
64POU5F1_16518401_ChIP-PET_MESCs_Mouse0.70908012
65HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70535624
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70510937
67NFIB_24661679_ChIP-Seq_LUNG_Mouse0.70510068
68* RACK7_27058665_Chip-Seq_MCF-7_Human0.69692154
69ZNF263_19887448_ChIP-Seq_K562_Human0.69611389
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69500108
71SMC4_20622854_ChIP-Seq_HELA_Human0.69188013
72POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.68681891
73SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68102652
74MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.67741178
75TP53_22127205_ChIP-Seq_IMR90_Human0.67237096
76PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66875012
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.66640687
78* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.63608576
79* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.62610953
80* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.62610953
81ESR1_21235772_ChIP-Seq_MCF-7_Human0.62048447
82RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61356182
83EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.61354737
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.60857554
85* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.60698464
86ZFX_18555785_ChIP-Seq_MESCs_Mouse0.60471040
87EGR1_19032775_ChIP-ChIP_M12_Human0.60438355
88CEBPB_22108803_ChIP-Seq_LS180_Human0.60175338
89EOMES_21245162_ChIP-Seq_HESCs_Human0.59538842
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.59304266
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.59166372
92NANOG_21062744_ChIP-ChIP_HESCs_Human0.59012856
93RAC3_21632823_ChIP-Seq_H3396_Human0.58326201
94FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.58190032
95PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57728768
96* GATA6_25053715_ChIP-Seq_YYC3_Human0.57111892
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.56834234
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.56794179
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.55259259
100STAT1_17558387_ChIP-Seq_HELA_Human0.54718208
101NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.54618865
102LXR_22292898_ChIP-Seq_THP-1_Human0.54551852
103MYC_19915707_ChIP-ChIP_AK7_Human0.54525699
104RBPJ_22232070_ChIP-Seq_NCS_Mouse0.54165334
105CSB_26484114_Chip-Seq_FIBROBLAST_Human0.53923225
106FOXO3_23340844_ChIP-Seq_DLD1_Human0.53789209
107AR_20517297_ChIP-Seq_VCAP_Human0.53788758
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53163189
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.53160295
110KLF4_18555785_ChIP-Seq_MESCs_Mouse0.52508084
111ESET_19884257_ChIP-Seq_ESCs_Mouse0.51122037
112FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50693127
113* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50196981
114GATA2_19941826_ChIP-Seq_K562_Human0.49887169
115* CBP_21632823_ChIP-Seq_H3396_Human0.47774069
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.47743534
117SOX2_20726797_ChIP-Seq_SW620_Human0.47720085
118ESR1_20079471_ChIP-ChIP_T-47D_Human0.46573421
119PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.46141494
120GATA1_19941826_ChIP-Seq_K562_Human0.45668240
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.45497047
122P53_21459846_ChIP-Seq_SAOS-2_Human0.45183402
123GATA1_19941827_ChIP-Seq_MEL_Mouse0.44801747
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44015251
125BCAT_22108803_ChIP-Seq_LS180_Human0.42825298
126CDX2_22108803_ChIP-Seq_LS180_Human0.41584259
127* TAF2_19829295_ChIP-Seq_ESCs_Human0.40632008
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.40385752
129SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.40200966
130ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.39197207
131SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.38544239
132FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.37857497
133LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35878656
134CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.35823228
135MYC_27129775_Chip-Seq_CORNEA_Mouse0.35263682
136FOXH1_21741376_ChIP-Seq_EPCs_Human0.34948200
137SPI1_26923725_Chip-Seq_HPCs_Mouse0.34657726
138NCOR_22424771_ChIP-Seq_293T_Human0.34644679
139ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.34479125
140* GATA3_24758297_ChIP-Seq_MCF-7_Human0.34143098
141ERG_21242973_ChIP-ChIP_JURKAT_Human0.33982640

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.31220313
2MP0005360_urolithiasis8.17385802
3* MP0005085_abnormal_gallbladder_physiolo6.15233151
4MP0005365_abnormal_bile_salt6.04249865
5* MP0008875_abnormal_xenobiotic_pharmacok4.89135804
6MP0003806_abnormal_nucleotide_metabolis4.03419617
7* MP0003252_abnormal_bile_duct3.74110978
8MP0010329_abnormal_lipoprotein_level3.56463254
9MP0009840_abnormal_foam_cell3.28404764
10MP0001666_abnormal_nutrient_absorption2.96976229
11MP0003122_maternal_imprinting2.88172221
12MP0005083_abnormal_biliary_tract2.88127129
13MP0005332_abnormal_amino_acid2.87746770
14MP0003195_calcinosis2.82553809
15MP0004019_abnormal_vitamin_homeostasis2.42827349
16MP0003191_abnormal_cellular_cholesterol2.18937350
17* MP0000609_abnormal_liver_physiology2.10044665
18MP0002138_abnormal_hepatobiliary_system2.07172346
19* MP0002118_abnormal_lipid_homeostasis2.05532791
20MP0003868_abnormal_feces_composition1.80969252
21MP0000566_synostosis1.78446631
22* MP0005319_abnormal_enzyme/_coenzyme1.75564400
23MP0002089_abnormal_postnatal_growth/wei1.65310216
24MP0001764_abnormal_homeostasis1.64127477
25MP0001915_intracranial_hemorrhage1.60518868
26MP0009697_abnormal_copulation1.59786149
27MP0005584_abnormal_enzyme/coenzyme_acti1.56276951
28MP0003123_paternal_imprinting1.52803117
29MP0005451_abnormal_body_composition1.46185952
30* MP0009643_abnormal_urine_homeostasis1.36379094
31MP0003172_abnormal_lysosome_physiology1.32269353
32MP0005409_darkened_coat_color1.25710388
33MP0003011_delayed_dark_adaptation1.22587712
34MP0009780_abnormal_chondrocyte_physiolo1.20446408
35MP0003186_abnormal_redox_activity1.19964990
36MP0003656_abnormal_erythrocyte_physiolo1.18998202
37MP0002132_abnormal_respiratory_system1.18286031
38* MP0000598_abnormal_liver_morphology1.12818500
39MP0003705_abnormal_hypodermis_morpholog1.12806294
40MP0002254_reproductive_system_inflammat1.07847294
41MP0005636_abnormal_mineral_homeostasis1.06256453
42MP0009764_decreased_sensitivity_to1.05367372
43MP0005647_abnormal_sex_gland1.03481633
44MP0000604_amyloidosis1.00028302
45MP0005257_abnormal_intraocular_pressure0.99326768
46MP0005084_abnormal_gallbladder_morpholo0.98130870
47MP0009763_increased_sensitivity_to0.95446791
48MP0003950_abnormal_plasma_membrane0.88285231
49* MP0009642_abnormal_blood_homeostasis0.87250767
50* MP0008469_abnormal_protein_level0.83906755
51MP0004272_abnormal_basement_membrane0.83536485
52MP0002876_abnormal_thyroid_physiology0.82196756
53MP0005408_hypopigmentation0.81946771
54MP0009765_abnormal_xenobiotic_induced0.79187410
55MP0005670_abnormal_white_adipose0.79110675
56MP0010368_abnormal_lymphatic_system0.78787179
57MP0006036_abnormal_mitochondrial_physio0.78771467
58MP0005376_homeostasis/metabolism_phenot0.78563214
59MP0002078_abnormal_glucose_homeostasis0.76902707
60MP0005076_abnormal_cell_differentiation0.75795850
61MP0003183_abnormal_peptide_metabolism0.73911087
62MP0001756_abnormal_urination0.72963803
63MP0003879_abnormal_hair_cell0.72375163
64MP0005220_abnormal_exocrine_pancreas0.71227558
65MP0002971_abnormal_brown_adipose0.70963760
66MP0005334_abnormal_fat_pad0.67459228
67MP0005535_abnormal_body_temperature0.67316199
68MP0005266_abnormal_metabolism0.66936338
69MP0009053_abnormal_anal_canal0.64547858
70MP0003566_abnormal_cell_adhesion0.64141965
71MP0001661_extended_life_span0.62452314
72MP0004043_abnormal_pH_regulation0.62344337
73MP0005448_abnormal_energy_balance0.61360531
74MP0004130_abnormal_muscle_cell0.61207824
75MP0005167_abnormal_blood-brain_barrier0.60794161
76MP0005023_abnormal_wound_healing0.60464178
77MP0001324_abnormal_eye_pigmentation0.60311013
78MP0003121_genomic_imprinting0.60128774
79MP0006054_spinal_hemorrhage0.59672004
80* MP0002136_abnormal_kidney_physiology0.58598021
81MP0003690_abnormal_glial_cell0.58424092
82MP0005164_abnormal_response_to0.57888950
83MP0000371_diluted_coat_color0.57542202
84MP0002822_catalepsy0.57458825
85MP0000003_abnormal_adipose_tissue0.56260809
86MP0006035_abnormal_mitochondrial_morpho0.56131617
87MP0003329_amyloid_beta_deposits0.55967039
88MP0003632_abnormal_nervous_system0.54461827
89MP0003943_abnormal_hepatobiliary_system0.53647241
90MP0002697_abnormal_eye_size0.52953866
91MP0003115_abnormal_respiratory_system0.52722769
92MP0002928_abnormal_bile_duct0.52007841
93MP0003638_abnormal_response/metabolism_0.51360217
94MP0002938_white_spotting0.51337968
95MP0000639_abnormal_adrenal_gland0.50687522
96MP0002092_abnormal_eye_morphology0.50680803
97MP0005464_abnormal_platelet_physiology0.49889326
98MP0005395_other_phenotype0.49851541
99MP0003718_maternal_effect0.48957748
100MP0004264_abnormal_extraembryonic_tissu0.48743100
101MP0003890_abnormal_embryonic-extraembry0.46536153
102MP0003567_abnormal_fetal_cardiomyocyte0.46006878
103MP0002160_abnormal_reproductive_system0.45796326
104MP0003315_abnormal_perineum_morphology0.45202273
105MP0000920_abnormal_myelination0.44168776
106MP0002909_abnormal_adrenal_gland0.43932515
107MP0008873_increased_physiological_sensi0.43584929
108MP0002282_abnormal_trachea_morphology0.43571498
109MP0002933_joint_inflammation0.43482324
110MP0004185_abnormal_adipocyte_glucose0.43216798
111MP0003699_abnormal_female_reproductive0.43197918
112MP0005410_abnormal_fertilization0.42845694
113MP0000858_altered_metastatic_potential0.42616540
114MP0008874_decreased_physiological_sensi0.42434392
115MP0008872_abnormal_physiological_respon0.42388470
116MP0001270_distended_abdomen0.42379333
117MP0002796_impaired_skin_barrier0.42260012
118MP0003953_abnormal_hormone_level0.42112666
119MP0004782_abnormal_surfactant_physiolog0.40851894
120MP0010234_abnormal_vibrissa_follicle0.40818770
121MP0003941_abnormal_skin_development0.40583166
122MP0005666_abnormal_adipose_tissue0.40228079
123MP0005166_decreased_susceptibility_to0.39523583
124MP0000230_abnormal_systemic_arterial0.38968294
125MP0003724_increased_susceptibility_to0.38837924
126MP0003436_decreased_susceptibility_to0.38749990
127MP0001765_abnormal_ion_homeostasis0.38677082
128MP0009384_cardiac_valve_regurgitation0.37736494
129MP0005248_abnormal_Harderian_gland0.36669752
130MP0000579_abnormal_nail_morphology0.35780955
131MP0009115_abnormal_fat_cell0.34454641
132MP0003075_altered_response_to0.33979661
133MP0002168_other_aberrant_phenotype0.33194433
134MP0009672_abnormal_birth_weight0.32846772
135MP0000538_abnormal_urinary_bladder0.32051741
136MP0004381_abnormal_hair_follicle0.31135220
137MP0003300_gastrointestinal_ulcer0.30393965
138MP0000249_abnormal_blood_vessel0.29326162
139MP0001881_abnormal_mammary_gland0.28582220
140MP0001845_abnormal_inflammatory_respons0.28470808
141MP0006082_CNS_inflammation0.27797290
142MP0005058_abnormal_lysosome_morphology0.26832530
143MP0002970_abnormal_white_adipose0.26821696
144MP0004147_increased_porphyrin_level0.26119070

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.21944391
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.07778147
3Deep venous thrombosis (HP:0002625)6.98974976
4Hypobetalipoproteinemia (HP:0003563)6.58553078
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.55950688
6Xanthomatosis (HP:0000991)6.24309094
7Prolonged partial thromboplastin time (HP:0003645)6.17000730
8Hyperlipoproteinemia (HP:0010980)5.14189920
9Complement deficiency (HP:0004431)5.10934386
10Hypolipoproteinemia (HP:0010981)4.78768843
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.75724425
12Hyperammonemia (HP:0001987)4.60070173
13Epidermoid cyst (HP:0200040)4.57933570
14Joint hemorrhage (HP:0005261)4.50151309
15Hyperglycinemia (HP:0002154)4.38422202
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34082924
17Fat malabsorption (HP:0002630)4.28574253
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.27295175
19Hyperglycinuria (HP:0003108)4.25880220
20Ketosis (HP:0001946)4.25576498
21Abnormality of aspartate family amino acid metabolism (HP:0010899)4.24819510
22Abnormality of the common coagulation pathway (HP:0010990)4.24744657
23Abnormality of serine family amino acid metabolism (HP:0010894)4.13067278
24Abnormality of glycine metabolism (HP:0010895)4.13067278
25Abnormality of methionine metabolism (HP:0010901)4.01182235
26Hypoalphalipoproteinemia (HP:0003233)3.96269668
27Hypoglycemic coma (HP:0001325)3.79594575
28Abnormality of pyrimidine metabolism (HP:0004353)3.76763622
29Abnormality of complement system (HP:0005339)3.70650841
30Hypercholesterolemia (HP:0003124)3.70121235
31Abnormality of the intrinsic pathway (HP:0010989)3.53582737
32Abnormality of fatty-acid metabolism (HP:0004359)3.37648315
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.30080652
34Abnormality of nucleobase metabolism (HP:0010932)3.26825115
35Ketoacidosis (HP:0001993)3.13678137
36* Hyperbilirubinemia (HP:0002904)3.09004594
37Delayed CNS myelination (HP:0002188)3.08882534
38Acanthocytosis (HP:0001927)3.05335510
39Steatorrhea (HP:0002570)3.02856083
40Abnormality of purine metabolism (HP:0004352)3.01855861
41Abnormality of serum amino acid levels (HP:0003112)2.99320684
42Hepatocellular carcinoma (HP:0001402)2.94371459
43Nephritis (HP:0000123)2.89694934
44Metabolic acidosis (HP:0001942)2.88301783
45Abnormality of carpal bone ossification (HP:0006257)2.84728083
46Myocardial infarction (HP:0001658)2.84526992
47Gout (HP:0001997)2.82054929
48Skin nodule (HP:0200036)2.79161043
49Spontaneous abortion (HP:0005268)2.78566662
50Abnormal tarsal ossification (HP:0008369)2.75625129
51Hypochromic microcytic anemia (HP:0004840)2.75554330
52Vascular calcification (HP:0004934)2.72547310
53Purpura (HP:0000979)2.69955574
54Systemic lupus erythematosus (HP:0002725)2.67069053
55Malnutrition (HP:0004395)2.64373681
56Small epiphyses (HP:0010585)2.63821535
57Flat acetabular roof (HP:0003180)2.61168130
58Lethargy (HP:0001254)2.60088827
59Abnormality of the nasal septum (HP:0000419)2.57894321
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.57095035
61Dicarboxylic aciduria (HP:0003215)2.57095035
62Osteomalacia (HP:0002749)2.53518589
63Increased serum pyruvate (HP:0003542)2.47460632
64* Conjugated hyperbilirubinemia (HP:0002908)2.46474734
65Hypoglycemic seizures (HP:0002173)2.45378074
66Abnormal gallbladder morphology (HP:0012437)2.44523176
67Abnormality of glycolysis (HP:0004366)2.44136753
68Spastic diplegia (HP:0001264)2.43721925
69Cardiovascular calcification (HP:0011915)2.41070389
70Arthropathy (HP:0003040)2.40675964
71Irritability (HP:0000737)2.39150868
72Abnormal gallbladder physiology (HP:0012438)2.38571452
73Cholecystitis (HP:0001082)2.38571452
74Cholelithiasis (HP:0001081)2.38476940
75Abnormality of proline metabolism (HP:0010907)2.35279776
76Hydroxyprolinuria (HP:0003080)2.35279776
77Glomerulonephritis (HP:0000099)2.34115939
78Broad alveolar ridges (HP:0000187)2.34050134
79Cerebral edema (HP:0002181)2.28771895
80Mitral stenosis (HP:0001718)2.28451703
81Poikilocytosis (HP:0004447)2.26675237
82Neonatal onset (HP:0003623)2.26625194
83Generalized aminoaciduria (HP:0002909)2.25493860
84Sensorimotor neuropathy (HP:0007141)2.22400693
85Esophageal varix (HP:0002040)2.20779211
86Pancreatitis (HP:0001733)2.18214893
87Recurrent gram-negative bacterial infections (HP:0005420)2.17878304
88Enlarged kidneys (HP:0000105)2.16607820
89Abnormality of the Achilles tendon (HP:0005109)2.16535218
90Pancreatic islet-cell hyperplasia (HP:0004510)2.15849597
91Late onset (HP:0003584)2.15770934
92Alkalosis (HP:0001948)2.14697495
93Amyloidosis (HP:0011034)2.13655800
94Rickets (HP:0002748)2.12722411
95Vomiting (HP:0002013)2.12184626
96Vaginal fistula (HP:0004320)2.10171413
97Abnormal ossification of hand bones (HP:0005921)2.09907817
98Proximal tubulopathy (HP:0000114)2.07851088
99Abnormal hand bone ossification (HP:0010660)2.07177115
100Abnormality of urine glucose concentration (HP:0011016)2.04801411
101Glycosuria (HP:0003076)2.04801411
102Brushfield spots (HP:0001088)2.02768697
103Menorrhagia (HP:0000132)2.02594578
104Gingival bleeding (HP:0000225)2.01896046
105Abnormality of the gallbladder (HP:0005264)1.99674732
106Hyperinsulinemic hypoglycemia (HP:0000825)1.97940810
107Bifid scrotum (HP:0000048)1.97223479
108Increased purine levels (HP:0004368)1.96931908
109Hyperuricemia (HP:0002149)1.96931908
110Opisthotonus (HP:0002179)1.96352951
111Thrombophlebitis (HP:0004418)1.95999980
112Abnormal enzyme/coenzyme activity (HP:0012379)1.95858282
113Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95576502
114Hemorrhage of the eye (HP:0011885)1.95220193
115Submucous cleft hard palate (HP:0000176)1.93020365
116Hypophosphatemic rickets (HP:0004912)1.88902874
117Abnormal cartilage morphology (HP:0002763)1.88572499
118Abnormality of vitamin metabolism (HP:0100508)1.88283309
119Asymmetry of the thorax (HP:0001555)1.88278413
120Abnormality of transition element cation homeostasis (HP:0011030)1.87127774
121Abnormality of the lumbar spine (HP:0100712)1.84341493
122Abnormal foot bone ossification (HP:0010675)1.83803327
123Broad palm (HP:0001169)1.83517815
124Renal cortical cysts (HP:0000803)1.83467035
125Potter facies (HP:0002009)1.81353997
126Facial shape deformation (HP:0011334)1.81353997
127Epiphyseal dysplasia (HP:0002656)1.78341017
128Abnormal delivery (HP:0001787)1.76250965
129Pigmentary retinal degeneration (HP:0001146)1.72332087
130Sex reversal (HP:0012245)1.71540757
131Abnormal sex determination (HP:0012244)1.71540757
132Widely patent fontanelles and sutures (HP:0004492)1.71103874
133Glomerulosclerosis (HP:0000096)1.67722030
134Reticulocytosis (HP:0001923)1.67436784
135Joint swelling (HP:0001386)1.66382362
136Abnormality of the acetabulum (HP:0003170)1.62914494
137Neoplasm of the liver (HP:0002896)1.61745661
138Focal segmental glomerulosclerosis (HP:0000097)1.59012317
139Neonatal death (HP:0003811)1.57207145
140Pulmonary embolism (HP:0002204)1.57124648
141Increased serum ferritin (HP:0003281)1.56605425
142Hepatoblastoma (HP:0002884)1.55627790
143Absent epiphyses (HP:0010577)1.55589797
144Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.55589797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.63694862
2FGFR44.35931483
3ERN14.29243163
4SIK14.24732140
5TAOK33.16266440
6INSRR3.10384391
7ERBB42.93843141
8CDK122.90721297
9MST1R2.72264579
10FRK2.31598998
11MAP2K42.16615979
12PKN22.06570745
13EEF2K2.02766466
14PDGFRA2.00385995
15TYRO31.96667875
16MAPK111.94814906
17FGFR11.92927543
18LATS11.90195492
19FLT31.73805275
20EIF2AK11.69947269
21PIK3CA1.68419745
22PTK61.64347419
23PIK3CG1.64316609
24TYK21.61176567
25GRK61.49114006
26SIK21.48401290
27DDR21.48186837
28WNK11.46836106
29TRIB31.44287810
30MAP3K71.39718813
31ABL21.39097007
32NEK91.32350788
33LATS21.30611495
34MAP3K101.29968474
35DAPK21.29522106
36STK391.27627006
37PRKAA21.26793148
38FGFR21.25251815
39JAK21.16236025
40STK38L1.15627975
41NEK21.14471383
42KDR1.13642684
43PDK21.13545641
44MAPKAPK31.13422011
45ERBB21.11126971
46CDK71.09068117
47MET1.03391461
48MAP3K141.02684090
49TBK11.02441449
50PINK11.00393563
51JAK10.97694807
52NEK10.96154798
53EPHB10.94819779
54MAPK40.94453190
55MAP2K30.93290724
56MAP3K30.91291521
57RIPK10.90291502
58PRKCZ0.89965208
59SCYL20.82165054
60CDK80.82001780
61IRAK30.79773783
62SGK30.78050040
63MAPK150.77336810
64WNK40.76888264
65PRKAA10.76689468
66CDK60.76646944
67BRSK10.76412050
68DYRK1B0.75631247
69PRKACG0.74439181
70GSK3A0.73233317
71CAMK1D0.71239334
72MAP3K110.70638583
73CSK0.69704647
74MAP2K60.69634938
75FGR0.69560766
76WNK30.68827518
77MAPK120.67194568
78MATK0.67188409
79PTK20.67105957
80MAP3K90.67044033
81BRD40.66669742
82EPHA30.66169248
83TIE10.65640532
84SMG10.65195151
85CAMK2G0.62515273
86CDC42BPA0.62432450
87CSNK1E0.61995345
88MELK0.61158990
89KSR20.61146047
90RPS6KB20.60180172
91AKT30.59767475
92RPS6KB10.58573808
93OXSR10.56964674
94SGK20.56822401
95PDPK10.55954148
96FGFR30.53592622
97PRKCQ0.49788006
98SGK4940.49787736
99SGK2230.49787736
100TGFBR20.49319428
101MAPK70.47931718
102IKBKE0.47447901
103BRSK20.47246389
104GRK10.46683958
105MAPKAPK50.45796378
106CSF1R0.45773947
107IGF1R0.41199608
108CSNK1G10.40674831
109MAP3K50.40253286
110MAP2K10.39071486
111PDK40.38777834
112PDK30.38777834
113ICK0.38449365
114MAP3K20.37181006
115BCR0.37049291
116EPHA20.36933418
117NUAK10.36352055
118CDK90.35974523
119CDK40.35081872
120RET0.34650117
121STK380.34180460
122PDK10.34166079
123MAP2K20.33810629
124MTOR0.33588386
125PBK0.33530105
126EPHA40.33336424
127CSNK2A20.32989657
128TAOK20.32821915
129MAP3K130.32753399
130SGK10.31884808
131CSNK1D0.31472298
132SRC0.31310661
133PRKG20.30939008
134MAP3K10.30708469
135EGFR0.30401348
136EIF2AK30.30313590
137BMX0.29946337
138MAP3K60.29761544
139PRKCA0.28569147
140PRKCG0.26847448
141PKN10.26644064
142AKT20.26337255
143PDGFRB0.25662324
144NTRK30.24648349
145ALK0.23013402
146CDK10.22824839
147NEK60.22301260
148CSNK2A10.22028980
149RPS6KA30.21651943

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31203044
2Nitrogen metabolism_Homo sapiens_hsa009103.57085531
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41086486
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.25927347
5Arginine biosynthesis_Homo sapiens_hsa002202.98660209
6Tryptophan metabolism_Homo sapiens_hsa003802.72653389
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62463749
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58805064
9Complement and coagulation cascades_Homo sapiens_hsa046102.56118800
10Fatty acid degradation_Homo sapiens_hsa000712.50359792
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45186367
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37092045
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32523031
14Butanoate metabolism_Homo sapiens_hsa006502.19323868
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.14528207
16Peroxisome_Homo sapiens_hsa041462.07959815
17Histidine metabolism_Homo sapiens_hsa003401.94243822
18Propanoate metabolism_Homo sapiens_hsa006401.93321548
19Chemical carcinogenesis_Homo sapiens_hsa052041.90436569
20Caffeine metabolism_Homo sapiens_hsa002321.89890957
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.89271344
22PPAR signaling pathway_Homo sapiens_hsa033201.89251285
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.87369929
24Fatty acid metabolism_Homo sapiens_hsa012121.79680272
25beta-Alanine metabolism_Homo sapiens_hsa004101.73699448
26Drug metabolism - other enzymes_Homo sapiens_hsa009831.73615464
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.72631951
28Retinol metabolism_Homo sapiens_hsa008301.67900841
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67389439
30Staphylococcus aureus infection_Homo sapiens_hsa051501.60756387
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.58843801
32Selenocompound metabolism_Homo sapiens_hsa004501.55726385
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.55488971
34* Bile secretion_Homo sapiens_hsa049761.53070267
35Phenylalanine metabolism_Homo sapiens_hsa003601.51022083
36Fat digestion and absorption_Homo sapiens_hsa049751.47449948
37Starch and sucrose metabolism_Homo sapiens_hsa005001.46016622
38Pyruvate metabolism_Homo sapiens_hsa006201.42285202
39Sulfur metabolism_Homo sapiens_hsa009201.38781511
40Tyrosine metabolism_Homo sapiens_hsa003501.34725894
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32996796
42Folate biosynthesis_Homo sapiens_hsa007901.30300555
43Fatty acid elongation_Homo sapiens_hsa000621.25844899
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.22843180
45Vitamin digestion and absorption_Homo sapiens_hsa049771.19208308
46Steroid biosynthesis_Homo sapiens_hsa001001.18510810
47Biosynthesis of amino acids_Homo sapiens_hsa012301.17047700
48Carbon metabolism_Homo sapiens_hsa012001.15073443
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.13714758
50* ABC transporters_Homo sapiens_hsa020101.11386244
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.10544563
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06652514
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05873473
54Arginine and proline metabolism_Homo sapiens_hsa003301.00095950
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93834840
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.90636641
57Vitamin B6 metabolism_Homo sapiens_hsa007500.86329485
58Lysine degradation_Homo sapiens_hsa003100.86119158
59Sulfur relay system_Homo sapiens_hsa041220.82632582
60Glutathione metabolism_Homo sapiens_hsa004800.77315885
61Glycerolipid metabolism_Homo sapiens_hsa005610.76280594
62Other glycan degradation_Homo sapiens_hsa005110.76043354
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75171769
64One carbon pool by folate_Homo sapiens_hsa006700.66179361
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66161404
66Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59046403
67Pentose phosphate pathway_Homo sapiens_hsa000300.57731680
68Fatty acid biosynthesis_Homo sapiens_hsa000610.52970540
69Metabolic pathways_Homo sapiens_hsa011000.46110650
70N-Glycan biosynthesis_Homo sapiens_hsa005100.44073903
71Galactose metabolism_Homo sapiens_hsa000520.43122595
72Fructose and mannose metabolism_Homo sapiens_hsa000510.34481278
73Pertussis_Homo sapiens_hsa051330.33586716
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27123568
75Prion diseases_Homo sapiens_hsa050200.26909906
76Insulin resistance_Homo sapiens_hsa049310.23492021
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21383279
78Linoleic acid metabolism_Homo sapiens_hsa005910.19666625
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.18089055
80Renin-angiotensin system_Homo sapiens_hsa046140.15838184
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.14294761
82Sphingolipid metabolism_Homo sapiens_hsa006000.08670275
83Glucagon signaling pathway_Homo sapiens_hsa049220.08472559
84Mineral absorption_Homo sapiens_hsa049780.03913427
85ECM-receptor interaction_Homo sapiens_hsa045120.02944983
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.01784968
87AMPK signaling pathway_Homo sapiens_hsa041520.01722071
88Type II diabetes mellitus_Homo sapiens_hsa04930-0.2406745
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2314293
90Bladder cancer_Homo sapiens_hsa05219-0.2260362
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2220366
92Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2062769
93Regulation of autophagy_Homo sapiens_hsa04140-0.1655138
94African trypanosomiasis_Homo sapiens_hsa05143-0.1590399
95Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1584479
96Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1527800
97Hepatitis C_Homo sapiens_hsa05160-0.1509334
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1433917
99Other types of O-glycan biosynthesis_Homo sapiens_hsa00514-0.1357239
100HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1346061
101Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1274916
102Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1267436
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.1233434
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1110015
105Protein digestion and absorption_Homo sapiens_hsa04974-0.0882242
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.0802045
107Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0781153
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0768691
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0360967

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