ABCC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.04800270
2L-phenylalanine catabolic process (GO:0006559)7.04800270
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74965433
4L-phenylalanine metabolic process (GO:0006558)6.74965433
5aromatic amino acid family catabolic process (GO:0009074)6.46722965
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.11171922
7tryptophan catabolic process (GO:0006569)5.95271597
8indole-containing compound catabolic process (GO:0042436)5.95271597
9indolalkylamine catabolic process (GO:0046218)5.95271597
10kynurenine metabolic process (GO:0070189)5.82972021
11bile acid biosynthetic process (GO:0006699)5.63220619
12tryptophan metabolic process (GO:0006568)5.62429702
13urea metabolic process (GO:0019627)5.55612058
14urea cycle (GO:0000050)5.55612058
15alpha-linolenic acid metabolic process (GO:0036109)5.52878247
16sulfur amino acid catabolic process (GO:0000098)5.43240894
17cysteine metabolic process (GO:0006534)5.33701168
18glyoxylate metabolic process (GO:0046487)5.32121037
19high-density lipoprotein particle remodeling (GO:0034375)5.30531112
20protein carboxylation (GO:0018214)5.24085016
21peptidyl-glutamic acid carboxylation (GO:0017187)5.24085016
22negative regulation of fibrinolysis (GO:0051918)5.24081706
23complement activation, alternative pathway (GO:0006957)5.20760009
24nitrogen cycle metabolic process (GO:0071941)5.09822923
25regulation of protein activation cascade (GO:2000257)5.06745843
26regulation of fibrinolysis (GO:0051917)5.02880979
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.97462316
28* bile acid metabolic process (GO:0008206)4.83844762
29serine family amino acid catabolic process (GO:0009071)4.81824394
30homocysteine metabolic process (GO:0050667)4.79442204
31regulation of complement activation (GO:0030449)4.75950873
32regulation of cholesterol esterification (GO:0010872)4.71222623
33reverse cholesterol transport (GO:0043691)4.69688679
34aromatic amino acid family metabolic process (GO:0009072)4.68349072
35regulation of triglyceride catabolic process (GO:0010896)4.64955900
36negative regulation of cholesterol transport (GO:0032375)4.61835101
37negative regulation of sterol transport (GO:0032372)4.61835101
38protein-lipid complex remodeling (GO:0034368)4.59386734
39macromolecular complex remodeling (GO:0034367)4.59386734
40plasma lipoprotein particle remodeling (GO:0034369)4.59386734
41phospholipid efflux (GO:0033700)4.55017982
42amino-acid betaine metabolic process (GO:0006577)4.54135451
43cellular glucuronidation (GO:0052695)4.52777820
44tyrosine metabolic process (GO:0006570)4.48475706
45acylglycerol homeostasis (GO:0055090)4.46460125
46triglyceride homeostasis (GO:0070328)4.46460125
47lysine catabolic process (GO:0006554)4.45047397
48lysine metabolic process (GO:0006553)4.45047397
49alpha-amino acid catabolic process (GO:1901606)4.36445830
50plasma lipoprotein particle clearance (GO:0034381)4.34156531
51* bile acid and bile salt transport (GO:0015721)4.32069675
52cellular ketone body metabolic process (GO:0046950)4.28860129
53cholesterol efflux (GO:0033344)4.22291169
54indolalkylamine metabolic process (GO:0006586)4.19578719
55benzene-containing compound metabolic process (GO:0042537)4.11219737
56cellular biogenic amine catabolic process (GO:0042402)4.11162955
57amine catabolic process (GO:0009310)4.11162955
58ethanol oxidation (GO:0006069)4.06502102
59glucuronate metabolic process (GO:0019585)4.05324430
60uronic acid metabolic process (GO:0006063)4.05324430
61cellular amino acid catabolic process (GO:0009063)4.05144612
62glycine metabolic process (GO:0006544)4.04568111
63glutamate metabolic process (GO:0006536)4.04344389
64imidazole-containing compound metabolic process (GO:0052803)4.03975217
65plasma lipoprotein particle assembly (GO:0034377)4.00908143
66drug catabolic process (GO:0042737)4.00589898
67coenzyme catabolic process (GO:0009109)3.99519784
68low-density lipoprotein particle remodeling (GO:0034374)3.96037071
69cellular modified amino acid catabolic process (GO:0042219)3.95384585
70daunorubicin metabolic process (GO:0044597)3.94801907
71polyketide metabolic process (GO:0030638)3.94801907
72doxorubicin metabolic process (GO:0044598)3.94801907
73serine family amino acid metabolic process (GO:0009069)3.91196840
74phospholipid homeostasis (GO:0055091)3.86172806
75fibrinolysis (GO:0042730)3.84291918
76response to nitrosative stress (GO:0051409)3.83306426
77very-low-density lipoprotein particle assembly (GO:0034379)3.75310430
78aldehyde catabolic process (GO:0046185)3.73864474
79cholesterol homeostasis (GO:0042632)3.73084224
80regulation of cholesterol homeostasis (GO:2000188)3.72515630
81dicarboxylic acid biosynthetic process (GO:0043650)3.72057205
82complement activation, classical pathway (GO:0006958)3.71881275
83negative regulation of lipase activity (GO:0060192)3.71794239
84arginine metabolic process (GO:0006525)3.71130493
85ketone body metabolic process (GO:1902224)3.69341094
86flavonoid metabolic process (GO:0009812)3.68974601
87regulation of bile acid biosynthetic process (GO:0070857)3.68564163
88complement activation (GO:0006956)3.68327350
89sterol homeostasis (GO:0055092)3.67591115
90positive regulation of lipid catabolic process (GO:0050996)3.65860614
91protein-lipid complex assembly (GO:0065005)3.65858472
92positive regulation of lipoprotein lipase activity (GO:0051006)3.64260693
93positive regulation of triglyceride lipase activity (GO:0061365)3.64260693
94serine family amino acid biosynthetic process (GO:0009070)3.64217870
95protein activation cascade (GO:0072376)3.59590972
96organic acid catabolic process (GO:0016054)3.59394563
97carboxylic acid catabolic process (GO:0046395)3.59394563
98cofactor catabolic process (GO:0051187)3.57972291
99desmosome organization (GO:0002934)3.57697669
100plasma lipoprotein particle organization (GO:0071827)3.55375306
101mannose metabolic process (GO:0006013)3.54725678
102short-chain fatty acid metabolic process (GO:0046459)3.51995938
103lipoprotein metabolic process (GO:0042157)3.49231857
104blood coagulation, intrinsic pathway (GO:0007597)3.47443513
105intestinal cholesterol absorption (GO:0030299)3.47022588
106aminoglycoside antibiotic metabolic process (GO:0030647)3.45403393
107negative regulation of hemostasis (GO:1900047)3.40056470
108negative regulation of blood coagulation (GO:0030195)3.40056470
109epoxygenase P450 pathway (GO:0019373)3.37931716
110semaphorin-plexin signaling pathway (GO:0071526)3.35176594
111regulation of plasminogen activation (GO:0010755)3.34866811
112drug transmembrane transport (GO:0006855)3.30522735
113hemidesmosome assembly (GO:0031581)3.29404340
114negative regulation of coagulation (GO:0050819)3.26815412
115primary alcohol catabolic process (GO:0034310)3.11216201
116intestinal absorption (GO:0050892)3.08899573
117exogenous drug catabolic process (GO:0042738)3.06951730
118negative regulation of wound healing (GO:0061045)3.05626784
119positive regulation of blood coagulation (GO:0030194)3.05513534
120positive regulation of hemostasis (GO:1900048)3.05513534
121regulation of apoptotic cell clearance (GO:2000425)3.05471413
122drug transport (GO:0015893)2.97597442
123epithelial cell-cell adhesion (GO:0090136)2.93108284
124regulation of cholesterol metabolic process (GO:0090181)2.92569714
125positive regulation of extracellular matrix organization (GO:1903055)2.88722700
126positive regulation of coagulation (GO:0050820)2.88576721
127negative regulation of fatty acid biosynthetic process (GO:0045717)2.86117019
128progesterone metabolic process (GO:0042448)2.80228137
129omega-hydroxylase P450 pathway (GO:0097267)2.77825099
130thrombin receptor signaling pathway (GO:0070493)2.75019427
131acute-phase response (GO:0006953)2.68571432
132sulfate transmembrane transport (GO:1902358)2.68042239
133drug metabolic process (GO:0017144)2.67839837
134mesodermal cell differentiation (GO:0048333)2.66230805
135regulation of integrin activation (GO:0033623)2.65188776
136glycoside metabolic process (GO:0016137)2.65151383
137peptide catabolic process (GO:0043171)2.59699083
138ethanol metabolic process (GO:0006067)2.54935059
139regulation of cholesterol biosynthetic process (GO:0045540)2.54358084
140positive regulation of fatty acid beta-oxidation (GO:0032000)2.52174761
141positive regulation of triglyceride metabolic process (GO:0090208)2.49014760
142negative regulation of protein activation cascade (GO:2000258)2.48611186
143lung epithelium development (GO:0060428)2.48137827
144fat-soluble vitamin biosynthetic process (GO:0042362)2.48123817
145actin filament depolymerization (GO:0030042)2.47579549
146negative regulation of lipid transport (GO:0032369)2.45205498
147regulation of hemostasis (GO:1900046)2.44120899
148regulation of blood coagulation (GO:0030193)2.44120899
149renal filtration (GO:0097205)2.43929304
150lung vasculature development (GO:0060426)2.43528974
151maintenance of gastrointestinal epithelium (GO:0030277)2.43241542
152glucose 6-phosphate metabolic process (GO:0051156)2.42781462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.94141141
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.88066677
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.49673841
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.28456398
5TP63_17297297_ChIP-ChIP_HaCaT_Human5.77601332
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.02214262
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61235483
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.58933372
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85139466
10* CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.53890686
11* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.24248774
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17779323
13* ELK3_25401928_ChIP-Seq_HUVEC_Human2.03941150
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.1125814
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.93817446
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.93692586
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.87073851
18SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.74363640
19CLOCK_20551151_ChIP-Seq_293T_Human1.68497769
20* FOXA2_19822575_ChIP-Seq_HepG2_Human1.66168199
21KDM2B_26808549_Chip-Seq_SUP-B15_Human1.64934076
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64595469
23GATA1_22025678_ChIP-Seq_K562_Human1.60465586
24KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59943801
25KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.59679927
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56375464
27P63_26484246_Chip-Seq_KERATINOCYTES_Human1.48347000
28RUNX1_27514584_Chip-Seq_MCF-7_Human1.48084299
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.47983333
30* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40754054
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37798395
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.36804645
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34890017
34SOX2_27498859_Chip-Seq_STOMACH_Mouse1.33215123
35RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33025414
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.33006392
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32200031
38* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.31851961
39SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30295287
40SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30295287
41ATF3_27146783_Chip-Seq_COLON_Human1.27772282
42TP53_22127205_ChIP-Seq_IMR90_Human1.27031412
43HTT_18923047_ChIP-ChIP_STHdh_Human1.26839942
44KDM2B_26808549_Chip-Seq_K562_Human1.26083781
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25636239
46* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24513396
47TRIM28_21343339_ChIP-Seq_HEK293_Human1.20469215
48P68_20966046_ChIP-Seq_HELA_Human1.18828887
49SMC4_20622854_ChIP-Seq_HELA_Human1.18412789
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17854373
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16346727
52TCF7_22412390_ChIP-Seq_EML_Mouse1.16159417
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15878299
54GATA4_25053715_ChIP-Seq_YYC3_Human1.14028089
55RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13888569
56ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13537267
57BCOR_27268052_Chip-Seq_Bcells_Human1.13112556
58* TP63_22573176_ChIP-Seq_HFKS_Human1.13072360
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.12976464
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.12668897
61BCL6_27268052_Chip-Seq_Bcells_Human1.09026662
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.08141621
63CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.07714792
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07324972
65SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07266866
66ESR2_21235772_ChIP-Seq_MCF-7_Human1.05735339
67* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05651301
68* KLF5_25053715_ChIP-Seq_YYC3_Human1.03580532
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03479979
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03462255
71NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02658215
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01737142
73HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01036226
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00363174
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00331156
76* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98349112
77JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98266166
78CREB1_26743006_Chip-Seq_LNCaP_Human0.97457288
79VDR_21846776_ChIP-Seq_THP-1_Human0.97120524
80SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96848203
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96483885
82JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96021115
83KDM2B_26808549_Chip-Seq_DND41_Human0.95737010
84RUNX1_22412390_ChIP-Seq_EML_Mouse0.94767096
85CTCF_27219007_Chip-Seq_Bcells_Human0.92683110
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.92014442
87ELF1_20517297_ChIP-Seq_JURKAT_Human0.91663215
88ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91191049
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.89622144
90ESR1_21235772_ChIP-Seq_MCF-7_Human0.87856821
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83206267
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82818213
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.79930272
94* CDX2_20551321_ChIP-Seq_CACO-2_Human0.77904460
95* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77803043
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.77225857
97IRF8_27001747_Chip-Seq_BMDM_Mouse0.77110590
98FOXO3_23340844_ChIP-Seq_DLD1_Human0.76909045
99* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.74834899
100ZNF263_19887448_ChIP-Seq_K562_Human0.73444282
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72874061
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72221990
103KAP1_22055183_ChIP-Seq_ESCs_Mouse0.71866870
104NRF2_20460467_ChIP-Seq_MEFs_Mouse0.71844405
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.71844405
106RARA_24833708_ChIP-Seq_LIVER_Mouse0.71325464
107GATA6_25053715_ChIP-Seq_YYC3_Human0.70664456
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.68772262
109ESR1_20079471_ChIP-ChIP_T-47D_Human0.68650349
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68539830
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.66137094
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64342072
113* LXR_22292898_ChIP-Seq_THP-1_Human0.64290572
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.63766637
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63496466
116SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62899447
117* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.62651890
118GATA2_19941826_ChIP-Seq_K562_Human0.62304366
119NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.62163049
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.61474585
121* SOX2_20726797_ChIP-Seq_SW620_Human0.61435693
122EGR1_19032775_ChIP-ChIP_M12_Human0.60275703
123CEBPB_22108803_ChIP-Seq_LS180_Human0.58865211
124* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.57969686
125RARB_24833708_ChIP-Seq_LIVER_Mouse0.57742702
126GATA1_19941826_ChIP-Seq_K562_Human0.57528172
127BRD4_27068464_Chip-Seq_AML-cells_Mouse0.57093657
128TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.55541695
129FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53742203
130GATA1_19941827_ChIP-Seq_MEL_Mouse0.53129860
131ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.52921274
132IRF8_21731497_ChIP-ChIP_J774_Mouse0.52131096
133* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.51975102
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.51901489
135* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.51694839
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.51493721
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.51078817
138BP1_19119308_ChIP-ChIP_Hs578T_Human0.51038518
139STAT1_17558387_ChIP-Seq_HELA_Human0.50036889
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.49718104
141ESET_19884257_ChIP-Seq_ESCs_Mouse0.49380478
142MYC_19915707_ChIP-ChIP_AK7_Human0.49119034
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.49011347
144ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.48446447
145RACK7_27058665_Chip-Seq_MCF-7_Human0.46773040
146PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.46325076
147AR_20517297_ChIP-Seq_VCAP_Human0.46000499
148CBP_21632823_ChIP-Seq_H3396_Human0.44360361
149EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.44254320
150BCAT_22108803_ChIP-Seq_LS180_Human0.43376120
151* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.43352336
152GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.43029069
153P53_21459846_ChIP-Seq_SAOS-2_Human0.42846191
154* GATA3_24758297_ChIP-Seq_MCF-7_Human0.42758525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.95863776
2MP0005360_urolithiasis7.27740270
3MP0005085_abnormal_gallbladder_physiolo6.23037141
4* MP0005365_abnormal_bile_salt5.72821341
5* MP0008875_abnormal_xenobiotic_pharmacok4.95137032
6MP0003252_abnormal_bile_duct4.00219626
7MP0003806_abnormal_nucleotide_metabolis3.85320860
8MP0010329_abnormal_lipoprotein_level3.51623072
9MP0009840_abnormal_foam_cell3.42593622
10MP0005083_abnormal_biliary_tract2.99724493
11MP0001666_abnormal_nutrient_absorption2.75194107
12MP0003191_abnormal_cellular_cholesterol2.65511778
13MP0005332_abnormal_amino_acid2.61863384
14MP0003195_calcinosis2.54153425
15MP0001849_ear_inflammation2.46808877
16MP0003172_abnormal_lysosome_physiology2.30322847
17MP0004019_abnormal_vitamin_homeostasis2.18470322
18MP0003566_abnormal_cell_adhesion2.18202484
19MP0000609_abnormal_liver_physiology2.18089642
20MP0002118_abnormal_lipid_homeostasis2.06932743
21MP0002138_abnormal_hepatobiliary_system2.02474557
22MP0005023_abnormal_wound_healing1.99018028
23MP0003868_abnormal_feces_composition1.85197602
24MP0005319_abnormal_enzyme/_coenzyme1.81846926
25MP0001764_abnormal_homeostasis1.55540553
26MP0004272_abnormal_basement_membrane1.53304102
27MP0001958_emphysema1.53145390
28MP0000858_altered_metastatic_potential1.52676742
29MP0005584_abnormal_enzyme/coenzyme_acti1.52627733
30MP0005451_abnormal_body_composition1.49211238
31MP0005257_abnormal_intraocular_pressure1.43241802
32MP0009643_abnormal_urine_homeostasis1.32131932
33MP0003705_abnormal_hypodermis_morpholog1.31813989
34MP0003011_delayed_dark_adaptation1.30494026
35MP0009697_abnormal_copulation1.28670660
36MP0005076_abnormal_cell_differentiation1.27695196
37MP0003186_abnormal_redox_activity1.27455998
38MP0003279_aneurysm1.25107753
39MP0003656_abnormal_erythrocyte_physiolo1.24806547
40MP0001664_abnormal_digestion1.24561548
41MP0003091_abnormal_cell_migration1.23621242
42MP0000598_abnormal_liver_morphology1.18906626
43MP0002254_reproductive_system_inflammat1.18818273
44MP0008438_abnormal_cutaneous_collagen1.17743136
45MP0000604_amyloidosis1.17158337
46MP0002998_abnormal_bone_remodeling1.15150167
47MP0005647_abnormal_sex_gland1.14708588
48MP0009764_decreased_sensitivity_to1.12776010
49MP0001533_abnormal_skeleton_physiology1.11081558
50MP0000467_abnormal_esophagus_morphology1.09554375
51MP0005409_darkened_coat_color1.09483266
52MP0009763_increased_sensitivity_to1.04638003
53MP0000566_synostosis1.03720795
54MP0008469_abnormal_protein_level1.02885103
55MP0004510_myositis1.01164304
56MP0008260_abnormal_autophagy1.00515136
57MP0000003_abnormal_adipose_tissue0.99289310
58MP0003879_abnormal_hair_cell0.99016941
59MP0005058_abnormal_lysosome_morphology0.96571658
60MP0002089_abnormal_postnatal_growth/wei0.94288902
61MP0002933_joint_inflammation0.93514240
62MP0005636_abnormal_mineral_homeostasis0.93205852
63MP0000537_abnormal_urethra_morphology0.89833821
64MP0001663_abnormal_digestive_system0.89356547
65MP0002060_abnormal_skin_morphology0.89109194
66MP0001216_abnormal_epidermal_layer0.88560934
67MP0001765_abnormal_ion_homeostasis0.88005402
68MP0010368_abnormal_lymphatic_system0.87834464
69* MP0009642_abnormal_blood_homeostasis0.87675571
70MP0003690_abnormal_glial_cell0.87427901
71MP0005375_adipose_tissue_phenotype0.87214124
72MP0005501_abnormal_skin_physiology0.86079258
73MP0000343_altered_response_to0.83826408
74MP0006082_CNS_inflammation0.82282201
75MP0005464_abnormal_platelet_physiology0.81939865
76MP0000678_abnormal_parathyroid_gland0.81858962
77MP0005595_abnormal_vascular_smooth0.81580343
78MP0005670_abnormal_white_adipose0.81208674
79MP0005408_hypopigmentation0.81151721
80MP0000538_abnormal_urinary_bladder0.80217867
81MP0000767_abnormal_smooth_muscle0.79546663
82MP0005165_increased_susceptibility_to0.78776664
83MP0002896_abnormal_bone_mineralization0.78238838
84MP0002877_abnormal_melanocyte_morpholog0.78159914
85MP0005381_digestive/alimentary_phenotyp0.77735050
86MP0003866_abnormal_defecation0.77126749
87MP0010386_abnormal_urinary_bladder0.76852404
88MP0003183_abnormal_peptide_metabolism0.76703951
89MP0009765_abnormal_xenobiotic_induced0.76519105
90MP0005376_homeostasis/metabolism_phenot0.75982576
91MP0003045_fibrosis0.74496853
92MP0001756_abnormal_urination0.74066576
93MP0000477_abnormal_intestine_morphology0.73276724
94MP0002971_abnormal_brown_adipose0.72390087
95MP0002078_abnormal_glucose_homeostasis0.71142066
96MP0003436_decreased_susceptibility_to0.71106454
97MP0004130_abnormal_muscle_cell0.70814177
98MP0005390_skeleton_phenotype0.70760376
99MP0000013_abnormal_adipose_tissue0.70558340
100MP0005334_abnormal_fat_pad0.69900653
101MP0005220_abnormal_exocrine_pancreas0.69071493
102MP0003300_gastrointestinal_ulcer0.68218991
103MP0003724_increased_susceptibility_to0.63502854
104MP0005084_abnormal_gallbladder_morpholo0.63310292
105MP0004782_abnormal_surfactant_physiolog0.61745078
106MP0005166_decreased_susceptibility_to0.60933974
107MP0009053_abnormal_anal_canal0.60609581
108MP0002136_abnormal_kidney_physiology0.60604960
109MP0005535_abnormal_body_temperature0.58938391
110MP0006036_abnormal_mitochondrial_physio0.58775884
111MP0005266_abnormal_metabolism0.57831349
112MP0002928_abnormal_bile_duct0.57050748
113MP0002876_abnormal_thyroid_physiology0.56734670
114MP0008873_increased_physiological_sensi0.56116153
115MP0003075_altered_response_to0.55849272
116MP0010234_abnormal_vibrissa_follicle0.53813773
117MP0004264_abnormal_extraembryonic_tissu0.53398697
118MP0003638_abnormal_response/metabolism_0.53053752
119MP0000639_abnormal_adrenal_gland0.52598077
120MP0005448_abnormal_energy_balance0.52284450
121MP0001845_abnormal_inflammatory_respons0.49723277
122MP0001661_extended_life_span0.49583962
123MP0005395_other_phenotype0.49572849
124MP0003329_amyloid_beta_deposits0.48838188
125MP0005666_abnormal_adipose_tissue0.48220792
126MP0005167_abnormal_blood-brain_barrier0.45066733
127MP0000249_abnormal_blood_vessel0.44936461
128MP0008874_decreased_physiological_sensi0.44572615
129MP0003718_maternal_effect0.44084897
130MP0009384_cardiac_valve_regurgitation0.41818687
131MP0004947_skin_inflammation0.39872103
132MP0002796_impaired_skin_barrier0.38746670
133MP0009115_abnormal_fat_cell0.38500043
134MP0001853_heart_inflammation0.38416117
135MP0002419_abnormal_innate_immunity0.37650067
136MP0004883_abnormal_blood_vessel0.37385165
137MP0003953_abnormal_hormone_level0.37310803
138MP0002168_other_aberrant_phenotype0.37048432
139MP0006035_abnormal_mitochondrial_morpho0.36833674
140MP0008004_abnormal_stomach_pH0.36806984
141MP0003453_abnormal_keratinocyte_physiol0.36123992
142MP0005164_abnormal_response_to0.35120005
143MP0001243_abnormal_dermal_layer0.34011819
144MP0000230_abnormal_systemic_arterial0.33880306
145MP0010155_abnormal_intestine_physiology0.33837929
146MP0003303_peritoneal_inflammation0.33382432
147MP0005248_abnormal_Harderian_gland0.32489855

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.08618358
2Intrahepatic cholestasis (HP:0001406)7.03140148
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.85669032
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.51211499
5Hypobetalipoproteinemia (HP:0003563)6.21818606
6Xanthomatosis (HP:0000991)6.18373857
7Prolonged partial thromboplastin time (HP:0003645)6.17940879
8Complement deficiency (HP:0004431)5.71906939
9Hyperlipoproteinemia (HP:0010980)5.22711765
10Hypolipoproteinemia (HP:0010981)4.69445405
11Joint hemorrhage (HP:0005261)4.66141794
12Epidermoid cyst (HP:0200040)4.50032124
13Hyperammonemia (HP:0001987)4.36293556
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.30497282
15Abnormality of complement system (HP:0005339)4.26886907
16Abnormality of the common coagulation pathway (HP:0010990)4.23644262
17Abnormality of glutamine family amino acid metabolism (HP:0010902)4.18684572
18Fat malabsorption (HP:0002630)4.17954404
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.16093375
20Hypoalphalipoproteinemia (HP:0003233)4.10977786
21Hyperglycinemia (HP:0002154)4.08602905
22Abnormality of methionine metabolism (HP:0010901)3.99166793
23Ketosis (HP:0001946)3.96892700
24Cervical subluxation (HP:0003308)3.96854890
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95370035
26J-shaped sella turcica (HP:0002680)3.85005282
27Hyperglycinuria (HP:0003108)3.82614064
28Conjugated hyperbilirubinemia (HP:0002908)3.80976870
29Hypercholesterolemia (HP:0003124)3.76656775
30Abnormality of serine family amino acid metabolism (HP:0010894)3.71017081
31Abnormality of glycine metabolism (HP:0010895)3.71017081
32Broad face (HP:0000283)3.70287201
33Dysostosis multiplex (HP:0000943)3.68673956
34Abnormality of the intrinsic pathway (HP:0010989)3.65385607
35Systemic lupus erythematosus (HP:0002725)3.64784930
36Urinary glycosaminoglycan excretion (HP:0003541)3.56840953
37Mucopolysacchariduria (HP:0008155)3.56840953
38Abnormality of pyrimidine metabolism (HP:0004353)3.56488377
39Hypoglycemic coma (HP:0001325)3.54561983
40Abnormality of mucopolysaccharide metabolism (HP:0011020)3.47150659
41Abnormality of polysaccharide metabolism (HP:0011012)3.47150659
42Abnormality of glycosaminoglycan metabolism (HP:0004371)3.47150659
43Myocardial infarction (HP:0001658)3.28925981
44Glomerulonephritis (HP:0000099)3.26636127
45Abnormality of fatty-acid metabolism (HP:0004359)3.25259519
46Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24570428
47Purpura (HP:0000979)3.22671037
48Hyperbilirubinemia (HP:0002904)3.14519218
49Steatorrhea (HP:0002570)3.10838142
50Distal lower limb amyotrophy (HP:0008944)3.03827491
51Abnormality of nucleobase metabolism (HP:0010932)3.03434359
52Focal segmental glomerulosclerosis (HP:0000097)2.98412098
53Increased mean platelet volume (HP:0011877)2.95740666
54Thin bony cortex (HP:0002753)2.92603806
55Hepatocellular carcinoma (HP:0001402)2.89535121
56Flat acetabular roof (HP:0003180)2.82622726
57Skin nodule (HP:0200036)2.82242596
58Ketoacidosis (HP:0001993)2.80292729
59Abnormality of purine metabolism (HP:0004352)2.76907350
60Protrusio acetabuli (HP:0003179)2.75598419
61Delayed CNS myelination (HP:0002188)2.75218443
62Abnormality of serum amino acid levels (HP:0003112)2.74219237
63Acanthocytosis (HP:0001927)2.68942129
64Spontaneous abortion (HP:0005268)2.66720623
65Abnormal platelet volume (HP:0011876)2.66680102
66Vascular calcification (HP:0004934)2.66576339
67Hypochromic microcytic anemia (HP:0004840)2.64036779
68Metabolic acidosis (HP:0001942)2.61672544
69Esophageal varix (HP:0002040)2.57453793
70Glomerulosclerosis (HP:0000096)2.57219827
71Recurrent gram-negative bacterial infections (HP:0005420)2.56662008
72Nuclear cataract (HP:0100018)2.55835514
73Atrophic scars (HP:0001075)2.53377838
74Malnutrition (HP:0004395)2.51406184
75Distal upper limb amyotrophy (HP:0007149)2.50661183
76Upper limb amyotrophy (HP:0009129)2.50661183
77Gout (HP:0001997)2.45845135
78Cholecystitis (HP:0001082)2.43820068
79Abnormal gallbladder physiology (HP:0012438)2.43820068
80Prolonged bleeding time (HP:0003010)2.42248168
81Abnormality of dicarboxylic acid metabolism (HP:0010995)2.40358797
82Dicarboxylic aciduria (HP:0003215)2.40358797
83Amyloidosis (HP:0011034)2.40349716
84Spastic diplegia (HP:0001264)2.39559985
85Abnormality of glycolipid metabolism (HP:0010969)2.38771313
86Abnormality of liposaccharide metabolism (HP:0010968)2.38771313
87Abnormality of glycosphingolipid metabolism (HP:0004343)2.38771313
88Joint stiffness (HP:0001387)2.37220476
89Abnormal gallbladder morphology (HP:0012437)2.36253420
90Lethargy (HP:0001254)2.36030847
91Cardiovascular calcification (HP:0011915)2.35676883
92Short nail (HP:0001799)2.35470541
93Mitral stenosis (HP:0001718)2.33690797
94Cholelithiasis (HP:0001081)2.31799627
95Cerebral aneurysm (HP:0004944)2.28169661
96Epistaxis (HP:0000421)2.27297501
97Sensorimotor neuropathy (HP:0007141)2.26281660
98Nephritis (HP:0000123)2.25312672
99Aortic regurgitation (HP:0001659)2.25206128
100Fragile skin (HP:0001030)2.24305842
101Premature rupture of membranes (HP:0001788)2.23413916
102Petechiae (HP:0000967)2.23212688
103Abnormality of the Achilles tendon (HP:0005109)2.22759523
104Irritability (HP:0000737)2.22482496
105Stridor (HP:0010307)2.22283131
106Hypoglycemic seizures (HP:0002173)2.20383695
107Menorrhagia (HP:0000132)2.20119648
108Gingival bleeding (HP:0000225)2.18838042
109Interstitial pulmonary disease (HP:0006530)2.17703542
110Hemorrhage of the eye (HP:0011885)2.17621247
111Abdominal distention (HP:0003270)2.17365782
112Pancreatitis (HP:0001733)2.14439814
113Arterial tortuosity (HP:0005116)2.10061329
114Late onset (HP:0003584)2.10060844
115Increased serum ferritin (HP:0003281)2.07281644
116Neonatal onset (HP:0003623)2.07018055
117Ulnar bowing (HP:0003031)2.06313759
118Vertebral compression fractures (HP:0002953)2.02691399
119Abnormality of proline metabolism (HP:0010907)2.01853214
120Hydroxyprolinuria (HP:0003080)2.01853214
121Vacuolated lymphocytes (HP:0001922)2.01624474
122Poikilocytosis (HP:0004447)2.00710561
123Thrombophlebitis (HP:0004418)1.99612487
124Deformed sella turcica (HP:0002681)1.98664506
125Cerebral edema (HP:0002181)1.96817319
126Axonal loss (HP:0003447)1.94501796
127Brushfield spots (HP:0001088)1.93096575
128Abnormality of the gallbladder (HP:0005264)1.92691064
129Vascular tortuosity (HP:0004948)1.92647445
130Rickets (HP:0002748)1.92479836
131Enlarged kidneys (HP:0000105)1.92069984
132Vomiting (HP:0002013)1.91912741
133Increased cerebral lipofuscin (HP:0011813)1.91396437
134Abnormality of transition element cation homeostasis (HP:0011030)1.90597137
135Abnormal cartilage morphology (HP:0002763)1.90490020
136Protuberant abdomen (HP:0001538)1.90185761
137Abnormality of iron homeostasis (HP:0011031)1.89753825
138Abnormal enzyme/coenzyme activity (HP:0012379)1.89143369
139Aneurysm (HP:0002617)1.88977904
140Biconcave vertebral bodies (HP:0004586)1.88496174
141Hyperacusis (HP:0010780)1.88200833
142Upper motor neuron abnormality (HP:0002127)1.86349625
143Generalized aminoaciduria (HP:0002909)1.86282306
144Elevated alkaline phosphatase (HP:0003155)1.84635637
145Opisthotonus (HP:0002179)1.84583034
146Abnormality of alkaline phosphatase activity (HP:0004379)1.83976089
147Alkalosis (HP:0001948)1.83293364
148Abnormal hair laboratory examination (HP:0003328)1.82459202
149Aortic aneurysm (HP:0004942)1.81842241
150Prolonged neonatal jaundice (HP:0006579)1.81790494
151Abnormal platelet function (HP:0011869)1.80144530
152Impaired platelet aggregation (HP:0003540)1.80144530
153Abnormality of vitamin metabolism (HP:0100508)1.79953707
154Milia (HP:0001056)1.78761432
155Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.78011311
156Bone pain (HP:0002653)1.76279411
157Hyperinsulinemic hypoglycemia (HP:0000825)1.76091783
158Cerebral palsy (HP:0100021)1.75619274
159Long toe (HP:0010511)1.73890881
160Stroke (HP:0001297)1.71860116
161Elevated hepatic transaminases (HP:0002910)1.70809539
162Hypophosphatemic rickets (HP:0004912)1.70655392
163Increased purine levels (HP:0004368)1.70137401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.61896033
2ERN14.27951516
3LMTK24.24121455
4FGFR43.81915432
5SIK13.78418548
6TAOK33.23164162
7ERBB42.61733938
8MST1R2.59200603
9INSRR2.42613152
10FRK2.38043175
11PKN22.16174070
12TGFBR22.07866830
13TYK22.04746292
14PDGFRA2.01177173
15MAP2K41.94996505
16LATS11.78137324
17TRIB31.76599270
18MAP2K31.74563604
19PTK61.73032169
20PIK3CG1.71447117
21MAPK111.63381806
22NTRK11.59087694
23DDR21.59013625
24TBK11.54522813
25FLT31.48864977
26NEK91.46677611
27MAPK151.44711946
28EPHB21.41824843
29PAK41.36848159
30CAMK1D1.35621426
31IRAK31.34720860
32JAK11.25041684
33TTN1.24120848
34JAK21.23776156
35CSF1R1.21377516
36CDC42BPA1.18114151
37PRKAA21.17516114
38MAP3K31.15990606
39DAPK21.15102083
40MAP3K141.14567977
41EPHB11.13565478
42KDR1.13412379
43RIPK11.12603325
44MATK1.10439941
45MAP3K71.10183562
46MYLK1.07646519
47ABL21.07097050
48CSK1.03968601
49ERBB21.00705498
50FGFR20.98985139
51PDGFRB0.97277366
52GRK60.97024070
53MAP3K100.95768174
54MET0.94286181
55CDK60.92537270
56MAP3K60.89303708
57PTK2B0.85236917
58MAPK40.80870949
59MAPK120.80816481
60TESK10.78859315
61MAP2K60.78440852
62CAMK1G0.76083936
63GSK3A0.75674837
64PRKD20.75538839
65MAP3K110.74948066
66EPHA20.74878299
67PRKCZ0.73581869
68FGR0.71811511
69MAPKAPK30.70274541
70IKBKE0.70002575
71MAP2K20.69030107
72JAK30.68586341
73PRKCI0.67198814
74WNK40.66859403
75DYRK1B0.63900406
76PTK20.63886337
77NUAK10.62244180
78RPS6KA20.62073395
79FER0.61988301
80PRKAA10.61721541
81ZAP700.61311854
82STK390.61207916
83ICK0.60209073
84PINK10.60114792
85MAP3K130.59350294
86NME20.58883829
87PRKACG0.58020848
88MAPK70.56952366
89PDPK10.56570368
90SGK30.55634770
91MAP2K10.54249614
92MARK20.53372203
93IGF1R0.53105515
94STK38L0.51417691
95EGFR0.50352492
96FGFR30.50156478
97KIT0.48710326
98CAMK2G0.48154265
99TIE10.47937647
100EPHA30.45172186
101IRAK10.44428654
102MAP4K10.44406823
103STK380.43640574
104BLK0.43265639
105MAP3K50.43149520
106STK30.43058480
107MAP3K20.42837967
108TAOK10.42100788
109IRAK20.41436434
110PRKCQ0.41330394
111MELK0.40999957
112IRAK40.40667567
113ACVR1B0.40656260
114MTOR0.40419771
115GRK10.39936648
116RET0.39665413
117STK100.39350282
118PHKG20.37686398
119PHKG10.37686398
120PDK10.37292922
121ILK0.37080089
122SMG10.37003307
123PIK3CA0.35597295
124ROCK10.35455871
125IKBKB0.35193462
126PRPF4B0.34742802
127MAPKAPK20.34555152
128ITK0.34184606
129TNK20.34117906
130BMX0.34006496
131PDK20.33368441
132SRC0.32961423
133MAP3K10.32566679
134TRPM70.31946929
135CSNK1G10.31566748
136RIPK40.31323072
137CAMK40.31311802
138ABL10.30345280
139CHUK0.30063997
140CDK90.29859413
141RPS6KL10.29500374
142RPS6KC10.29500374
143CDK80.29144194
144PRKG20.28923078
145PDK40.28686952
146PDK30.28686952

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.31321062
2Nitrogen metabolism_Homo sapiens_hsa009103.59058872
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.49087041
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.09408744
5Arginine biosynthesis_Homo sapiens_hsa002202.96034280
6Complement and coagulation cascades_Homo sapiens_hsa046102.74902934
7Tryptophan metabolism_Homo sapiens_hsa003802.66859467
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.56087663
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.46650558
10Fatty acid degradation_Homo sapiens_hsa000712.45469410
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.44842928
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.33325998
13Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.31762158
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29355162
15Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.12249282
16Chemical carcinogenesis_Homo sapiens_hsa052042.10669743
17Staphylococcus aureus infection_Homo sapiens_hsa051502.05494228
18Butanoate metabolism_Homo sapiens_hsa006502.05175757
19Peroxisome_Homo sapiens_hsa041462.00969706
20Caffeine metabolism_Homo sapiens_hsa002322.00332178
21Histidine metabolism_Homo sapiens_hsa003401.93166202
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.91357839
23PPAR signaling pathway_Homo sapiens_hsa033201.89769659
24Propanoate metabolism_Homo sapiens_hsa006401.82757924
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.75848911
26Retinol metabolism_Homo sapiens_hsa008301.75675655
27Fatty acid metabolism_Homo sapiens_hsa012121.74438216
28beta-Alanine metabolism_Homo sapiens_hsa004101.69098057
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.66825022
30Selenocompound metabolism_Homo sapiens_hsa004501.63267619
31ECM-receptor interaction_Homo sapiens_hsa045121.61210883
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.56899049
33Sulfur metabolism_Homo sapiens_hsa009201.52637191
34* Bile secretion_Homo sapiens_hsa049761.48482192
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46506496
36Phenylalanine metabolism_Homo sapiens_hsa003601.42763831
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.42665250
38Starch and sucrose metabolism_Homo sapiens_hsa005001.38940941
39Tyrosine metabolism_Homo sapiens_hsa003501.29202694
40Fat digestion and absorption_Homo sapiens_hsa049751.28973607
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28548031
42Pyruvate metabolism_Homo sapiens_hsa006201.25640576
43* ABC transporters_Homo sapiens_hsa020101.22019842
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.19788759
45Fatty acid elongation_Homo sapiens_hsa000621.18893682
46Folate biosynthesis_Homo sapiens_hsa007901.17121024
47Steroid biosynthesis_Homo sapiens_hsa001001.11349242
48Biosynthesis of amino acids_Homo sapiens_hsa012301.08792088
49Carbon metabolism_Homo sapiens_hsa012001.04614124
50Vitamin digestion and absorption_Homo sapiens_hsa049770.98063533
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.96242373
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93825664
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93022029
54Vitamin B6 metabolism_Homo sapiens_hsa007500.90716505
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.90090033
56Arginine and proline metabolism_Homo sapiens_hsa003300.89983691
57Platelet activation_Homo sapiens_hsa046110.88180154
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86503123
59Sulfur relay system_Homo sapiens_hsa041220.85221371
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84518532
61Focal adhesion_Homo sapiens_hsa045100.84320391
62Lysine degradation_Homo sapiens_hsa003100.83403207
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81914228
64Sphingolipid metabolism_Homo sapiens_hsa006000.81143189
65Glutathione metabolism_Homo sapiens_hsa004800.81135485
66Glycerolipid metabolism_Homo sapiens_hsa005610.72885682
67Notch signaling pathway_Homo sapiens_hsa043300.71164797
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70142935
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.66713873
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62949745
71TNF signaling pathway_Homo sapiens_hsa046680.60931674
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60686026
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60625324
74One carbon pool by folate_Homo sapiens_hsa006700.59121275
75Pentose phosphate pathway_Homo sapiens_hsa000300.57757044
76Pancreatic secretion_Homo sapiens_hsa049720.53564103
77Fatty acid biosynthesis_Homo sapiens_hsa000610.52048468
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.51316910
79VEGF signaling pathway_Homo sapiens_hsa043700.50013311
80Bladder cancer_Homo sapiens_hsa052190.47480011
81Toxoplasmosis_Homo sapiens_hsa051450.42855812
82Prion diseases_Homo sapiens_hsa050200.41867068
83Metabolic pathways_Homo sapiens_hsa011000.41487739
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41337665
85Small cell lung cancer_Homo sapiens_hsa052220.41058675
86Vibrio cholerae infection_Homo sapiens_hsa051100.39310146
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38989258
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37591816
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.35497488
90Osteoclast differentiation_Homo sapiens_hsa043800.34813014
91Protein digestion and absorption_Homo sapiens_hsa049740.33668485
92Choline metabolism in cancer_Homo sapiens_hsa052310.33438691
93Proteoglycans in cancer_Homo sapiens_hsa052050.33342641
94Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33102158
95Galactose metabolism_Homo sapiens_hsa000520.33052962
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.32988154
97Fructose and mannose metabolism_Homo sapiens_hsa000510.32381875
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32022118
99Salmonella infection_Homo sapiens_hsa051320.31710298
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.31692612
101Shigellosis_Homo sapiens_hsa051310.30448409
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.30196383
103Malaria_Homo sapiens_hsa051440.30098142
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29061824
105GnRH signaling pathway_Homo sapiens_hsa049120.28969855
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28326363
107Insulin resistance_Homo sapiens_hsa049310.27671325
108Thyroid hormone synthesis_Homo sapiens_hsa049180.27397701
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.24946815
110Linoleic acid metabolism_Homo sapiens_hsa005910.24105014
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.21721602
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.05244188
113Glucagon signaling pathway_Homo sapiens_hsa049220.03455355
114Lysosome_Homo sapiens_hsa041420.01123435
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.00661749
116Regulation of autophagy_Homo sapiens_hsa04140-0.1745163
117Toll-like receptor signaling pathway_Homo sapiens_hsa04620-0.1743070
118Legionellosis_Homo sapiens_hsa05134-0.1655724
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1476010
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1424288
121Amoebiasis_Homo sapiens_hsa05146-0.1344656
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.1264555
123Insulin signaling pathway_Homo sapiens_hsa04910-0.1246220
124Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1217084
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1109109
126Hepatitis C_Homo sapiens_hsa05160-0.0689840
127Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0661223
128African trypanosomiasis_Homo sapiens_hsa05143-0.0441548
129Mineral absorption_Homo sapiens_hsa04978-0.0350982
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0274593
131Pertussis_Homo sapiens_hsa05133-0.0097266
132Other glycan degradation_Homo sapiens_hsa00511-0.0081391
133Renin-angiotensin system_Homo sapiens_hsa04614-0.0039319
134AMPK signaling pathway_Homo sapiens_hsa04152-0.0025627

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