ABCC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1iron ion import (GO:0097286)6.66982972
2thrombin receptor signaling pathway (GO:0070493)6.30213713
3nuclear pore complex assembly (GO:0051292)4.85296586
4mesodermal cell differentiation (GO:0048333)4.79781083
5nuclear pore organization (GO:0006999)4.69139618
6platelet aggregation (GO:0070527)4.61474019
7regulation of integrin activation (GO:0033623)4.46894743
8protein localization to kinetochore (GO:0034501)4.45559407
9import into cell (GO:0098657)4.37050302
10definitive hemopoiesis (GO:0060216)4.28998933
11hypotonic response (GO:0006971)4.08549075
12folic acid-containing compound biosynthetic process (GO:0009396)4.06459867
13phospholipid scrambling (GO:0017121)4.01671230
14pore complex assembly (GO:0046931)3.91456465
15regulation of platelet aggregation (GO:0090330)3.87461338
16IMP biosynthetic process (GO:0006188)3.83919905
17protoporphyrinogen IX metabolic process (GO:0046501)3.83117079
18regulation of integrin-mediated signaling pathway (GO:2001044)3.81613813
19regulation of posttranscriptional gene silencing (GO:0060147)3.78992813
20regulation of gene silencing by miRNA (GO:0060964)3.78992813
21regulation of gene silencing by RNA (GO:0060966)3.78992813
22regulation of translational fidelity (GO:0006450)3.68557215
23biotin metabolic process (GO:0006768)3.67900522
24DNA unwinding involved in DNA replication (GO:0006268)3.60531926
25branching involved in prostate gland morphogenesis (GO:0060442)3.58866868
26mitotic nuclear envelope disassembly (GO:0007077)3.57628019
27IMP metabolic process (GO:0046040)3.50989080
28protein localization to chromosome, centromeric region (GO:0071459)3.45555610
29negative regulation of homotypic cell-cell adhesion (GO:0034111)3.44781292
30polyamine biosynthetic process (GO:0006596)3.40587115
31membrane disassembly (GO:0030397)3.33985962
32nuclear envelope disassembly (GO:0051081)3.33985962
33interkinetic nuclear migration (GO:0022027)3.31238923
34megakaryocyte development (GO:0035855)3.29383860
35regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.27987398
36linoleic acid metabolic process (GO:0043651)3.27627289
37regulation of RNA export from nucleus (GO:0046831)3.26701484
38regulation of Golgi to plasma membrane protein transport (GO:0042996)3.25172616
39glucocorticoid receptor signaling pathway (GO:0042921)3.21002591
40DNA duplex unwinding (GO:0032508)3.13177823
41DNA geometric change (GO:0032392)3.12199868
42regulation of histone H3-K9 methylation (GO:0051570)3.11576623
43heterochromatin organization (GO:0070828)3.10628201
44DNA replication initiation (GO:0006270)3.07807959
45negative regulation of DNA repair (GO:0045738)3.04448410
46regulation of platelet activation (GO:0010543)3.04184146
47determination of adult lifespan (GO:0008340)3.01895166
48mitotic metaphase plate congression (GO:0007080)2.99234130
49dosage compensation (GO:0007549)2.94124953
50negative regulation of stress fiber assembly (GO:0051497)2.91272193
51corticosteroid receptor signaling pathway (GO:0031958)2.91150061
52embryonic process involved in female pregnancy (GO:0060136)2.90835090
53positive regulation of osteoblast proliferation (GO:0033690)2.90337376
54negative regulation of focal adhesion assembly (GO:0051895)2.87647701
55negative regulation of cell junction assembly (GO:1901889)2.87647701
56negative regulation of adherens junction organization (GO:1903392)2.87647701
57metaphase plate congression (GO:0051310)2.87324417
58DNA strand elongation involved in DNA replication (GO:0006271)2.86766982
59mitotic sister chromatid segregation (GO:0000070)2.86295601
60sister chromatid segregation (GO:0000819)2.85110820
61regulation of gene silencing (GO:0060968)2.83578709
62fibroblast migration (GO:0010761)2.81379161
63negative regulation of protein localization to cell surface (GO:2000009)2.81354781
64formation of translation preinitiation complex (GO:0001731)2.81139137
65negative regulation of histone methylation (GO:0031061)2.79388381
66telomere maintenance via semi-conservative replication (GO:0032201)2.77798945
67positive regulation of steroid hormone secretion (GO:2000833)2.77793132
68negative regulation of neurotransmitter secretion (GO:0046929)2.74953027
69homotypic cell-cell adhesion (GO:0034109)2.74875258
70DNA strand elongation (GO:0022616)2.73238556
71positive regulation of Rho protein signal transduction (GO:0035025)2.72566366
72positive regulation of SMAD protein import into nucleus (GO:0060391)2.71545596
73regulation of helicase activity (GO:0051095)2.70046277
74attachment of spindle microtubules to kinetochore (GO:0008608)2.66417859
75DNA replication checkpoint (GO:0000076)2.65612737
76regulation of immune response to tumor cell (GO:0002837)2.64621690
77regulation of response to tumor cell (GO:0002834)2.64621690
78positive regulation of response to tumor cell (GO:0002836)2.64621690
79positive regulation of immune response to tumor cell (GO:0002839)2.64621690
80establishment of endothelial barrier (GO:0061028)2.64463371
81blood coagulation, intrinsic pathway (GO:0007597)2.63238010
82* platelet degranulation (GO:0002576)2.63210015
83establishment of chromosome localization (GO:0051303)2.63203091
84apoptotic process involved in morphogenesis (GO:0060561)2.63153555
85nuclear envelope organization (GO:0006998)2.62348855
86cell-substrate junction assembly (GO:0007044)2.62057818
87platelet formation (GO:0030220)2.60629975
88regulation of telomere maintenance via telomerase (GO:0032210)2.60625372
89long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.59648641
90endocardial cushion development (GO:0003197)2.58660777
91negative regulation of erythrocyte differentiation (GO:0045647)2.56624924
92lipoxygenase pathway (GO:0019372)2.56495561
93nucleobase biosynthetic process (GO:0046112)2.56013035
94regulation of spindle organization (GO:0090224)2.55987233
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.55748302
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.55748302
97positive regulation of mitotic sister chromatid separation (GO:1901970)2.55748302
98hepatocyte apoptotic process (GO:0097284)2.55498773
99artery development (GO:0060840)2.55372809
100regulation of sister chromatid cohesion (GO:0007063)2.55255129
101lung vasculature development (GO:0060426)2.55070365
102lung lobe morphogenesis (GO:0060463)2.54950003
103mitotic recombination (GO:0006312)2.52888188
104negative regulation of gene silencing (GO:0060969)2.52814898
105regulation of homotypic cell-cell adhesion (GO:0034110)2.52530698
106regulation of protein heterodimerization activity (GO:0043497)2.52453622
107DNA replication-dependent nucleosome assembly (GO:0006335)2.50906039
108DNA replication-dependent nucleosome organization (GO:0034723)2.50906039
109mitotic chromosome condensation (GO:0007076)2.50736710
110angiogenesis involved in wound healing (GO:0060055)2.50110648
111neutrophil activation involved in immune response (GO:0002283)2.50030808
112telomere maintenance via recombination (GO:0000722)2.49885337
113pre-miRNA processing (GO:0031054)2.49193739
114positive regulation of receptor recycling (GO:0001921)2.48947536
115pteridine-containing compound biosynthetic process (GO:0042559)2.47855709
116regulation of nucleobase-containing compound transport (GO:0032239)2.47663046
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.47509500
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47509500
119regulation of mitotic spindle organization (GO:0060236)2.46685682
120mitotic G1 DNA damage checkpoint (GO:0031571)2.46333263
121chromatin assembly (GO:0031497)2.45778851
122ribosomal small subunit assembly (GO:0000028)2.45710092
123positive regulation of protein import into nucleus, translocation (GO:0033160)2.45604022
124Golgi transport vesicle coating (GO:0048200)2.45600923
125COPI coating of Golgi vesicle (GO:0048205)2.45600923
126regulation of hippo signaling (GO:0035330)2.45257147
127cytoplasmic mRNA processing body assembly (GO:0033962)2.45103350
128positive regulation of hemostasis (GO:1900048)2.45046697
129positive regulation of blood coagulation (GO:0030194)2.45046697
130regulation of SMAD protein import into nucleus (GO:0060390)2.44245827
131protein K6-linked ubiquitination (GO:0085020)2.43038001
132positive regulation of cardiac muscle hypertrophy (GO:0010613)2.42736304
133positive regulation of muscle hypertrophy (GO:0014742)2.42736304
134positive regulation of chromosome segregation (GO:0051984)2.41990378
135cell adhesion mediated by integrin (GO:0033627)2.41833404
136negative regulation of neural precursor cell proliferation (GO:2000178)2.40758757
137regulation of membrane lipid distribution (GO:0097035)2.40122288
138maturation of SSU-rRNA (GO:0030490)2.40115888
139interferon-gamma secretion (GO:0072643)2.40058848
140negative regulation of protein localization to plasma membrane (GO:1903077)2.39748641
141response to UV-C (GO:0010225)2.39149636
142regulation of chromatin silencing (GO:0031935)2.39131975
143positive regulation of endothelial cell differentiation (GO:0045603)2.39014448
144regulation of histone H3-K4 methylation (GO:0051569)2.37093577
145peptidyl-lysine dimethylation (GO:0018027)2.36144242
146monoubiquitinated protein deubiquitination (GO:0035520)2.35636119
147COPII vesicle coating (GO:0048208)2.35326094
148positive regulation of granulocyte differentiation (GO:0030854)2.34235671
149DNA conformation change (GO:0071103)2.33485558
150SMAD protein complex assembly (GO:0007183)2.33220520
151regulation of megakaryocyte differentiation (GO:0045652)2.32291601
152pentose-phosphate shunt (GO:0006098)2.31282214
153protein localization to chromosome (GO:0034502)2.31069911
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.30885449
155erythrocyte maturation (GO:0043249)2.30852030
156meiotic chromosome segregation (GO:0045132)2.30359649
157beta-amyloid metabolic process (GO:0050435)2.30357290
158regulation of translational termination (GO:0006449)2.30201794
159viral transcription (GO:0019083)2.30043894
160translational termination (GO:0006415)2.29607618
161antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.29326876
162antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.29326876
163myeloid cell development (GO:0061515)2.28669884
164fatty acid elongation (GO:0030497)2.27751364
165histone H4-K12 acetylation (GO:0043983)2.27273019
166kinetochore organization (GO:0051383)2.27128404
167protoporphyrinogen IX biosynthetic process (GO:0006782)2.26108438
168regulation of translation in response to stress (GO:0043555)2.26063570
169regulation of erythrocyte differentiation (GO:0045646)2.26036981
170mRNA stabilization (GO:0048255)2.25535054
171RNA stabilization (GO:0043489)2.25535054
172retinal metabolic process (GO:0042574)2.24774819
173mitotic sister chromatid cohesion (GO:0007064)2.24731299
174spindle assembly involved in mitosis (GO:0090307)2.24397287
175negative regulation of platelet activation (GO:0010544)2.24377217
176tetrahydrofolate metabolic process (GO:0046653)2.24260980
177positive regulation of coagulation (GO:0050820)2.24207344
178focal adhesion assembly (GO:0048041)2.24073408
179cell-substrate adherens junction assembly (GO:0007045)2.24073408
180negative regulation of potassium ion transmembrane transport (GO:1901380)2.23662550
181telomere maintenance via telomere lengthening (GO:0010833)2.23033705
182nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.22747535
183establishment of apical/basal cell polarity (GO:0035089)2.20857245
184trophectodermal cell differentiation (GO:0001829)2.19719988
185regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.19248018
186microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.18933263
187morphogenesis of an endothelium (GO:0003159)2.18836005

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.29580098
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.78071740
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.58496602
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.23692131
5MYC_18555785_ChIP-Seq_MESCs_Mouse2.80846092
6* GATA1_19941826_ChIP-Seq_K562_Human2.75032195
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.64839376
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.53114965
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.46435441
10* GATA2_19941826_ChIP-Seq_K562_Human2.29623927
11* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.25260538
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.22418885
13MYC_22102868_ChIP-Seq_BL_Human2.22352281
14GATA2_21666600_ChIP-Seq_HMVEC_Human2.20408739
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.12348334
16* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10019494
17* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03618037
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.00052150
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.00052150
20KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.00052150
21* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.91821379
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.90644648
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89147764
24CHD1_26751641_Chip-Seq_LNCaP_Human1.87781657
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.85743334
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85119959
27STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77606722
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77491605
29PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.76096068
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.75269546
31PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75245109
32AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.73836519
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.73683173
34CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.73045676
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.71957132
36* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.71251711
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.71145012
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68907730
39* AR_21909140_ChIP-Seq_LNCAP_Human1.68515690
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.66179616
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.63693024
42GATA1_19941827_ChIP-Seq_MEL_Mouse1.63655952
43VDR_21846776_ChIP-Seq_THP-1_Human1.60777167
44MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58645172
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56273251
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55885703
47* FOXO3_23340844_ChIP-Seq_DLD1_Human1.55049093
48FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.54147742
49BRD4_25478319_ChIP-Seq_HGPS_Human1.52943186
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52065752
51* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50483522
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45581711
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45581711
54TFEB_21752829_ChIP-Seq_HELA_Human1.43341254
55* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39529058
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.39472003
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38836663
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.38398339
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37940804
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37595896
61SCL_19346495_ChIP-Seq_HPC-7_Human1.36758322
62* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.34194039
63GATA4_21415370_ChIP-Seq_HL-1_Mouse1.33223073
64* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.31569696
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.31268654
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30943371
67XRN2_22483619_ChIP-Seq_HELA_Human1.30200939
68MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30020822
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.29706014
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29446556
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29445540
72HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.29216590
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.28248647
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.25754247
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25066484
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23082648
77* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.22784204
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21391323
79CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21004835
80* SPI1_23127762_ChIP-Seq_K562_Human1.20544938
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20514842
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19908816
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18859370
84KDM5A_27292631_Chip-Seq_BREAST_Human1.18752350
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18629117
86SPI1_23547873_ChIP-Seq_NB4_Human1.18536581
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18064774
88TCF7_22412390_ChIP-Seq_EML_Mouse1.17456298
89NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16284789
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.15968680
91* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15261296
92ZNF263_19887448_ChIP-Seq_K562_Human1.15164425
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.14372245
94MAF_26560356_Chip-Seq_TH1_Human1.14245586
95GATA1_19941827_ChIP-Seq_MEL86_Mouse1.14217991
96MYB_26560356_Chip-Seq_TH2_Human1.14205900
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.12646805
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.12418514
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12356126
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12137585
101CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11879065
102* GATA6_25053715_ChIP-Seq_YYC3_Human1.11859912
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11852214
104VDR_23849224_ChIP-Seq_CD4+_Human1.11393852
105* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11020296
106* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11020296
107MYB_26560356_Chip-Seq_TH1_Human1.10828940
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10450138
109KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10361799
110FOXA1_25552417_ChIP-Seq_VCAP_Human1.10155190
111NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09512218
112FOXP3_21729870_ChIP-Seq_TREG_Human1.09273360
113UTX_26944678_Chip-Seq_JUKART_Human1.07687742
114ELK1_19687146_ChIP-ChIP_HELA_Human1.07652405
115EST1_17652178_ChIP-ChIP_JURKAT_Human1.07448934
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05718833
117ETS1_22383799_ChIP-Seq_G1ME_Mouse1.05714545
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.05413998
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04799250
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03840691
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03496067
122* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03234714
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02789683
124ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02208447
125ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02034116
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02022927
127SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01967898
128CIITA_25753668_ChIP-Seq_RAJI_Human1.01798175
129NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01629872
130NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01569485
131* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01094539
132* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.00521678
133GATA1_22025678_ChIP-Seq_K562_Human1.00436793
134NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00387573
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00029771
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98382542
137* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98122886
138ETS1_20019798_ChIP-Seq_JURKAT_Human0.97242695
139CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96791082
140TTF2_22483619_ChIP-Seq_HELA_Human0.96759619
141DCP1A_22483619_ChIP-Seq_HELA_Human0.96626882
142* ATF3_27146783_Chip-Seq_COLON_Human0.95157734
143TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95046836
144DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94768369
145GABP_19822575_ChIP-Seq_HepG2_Human0.94583594
146SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93365994
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93193969
148FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93177745
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92926262
150STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92901601
151* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92883805
152* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92858804
153SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92753524
154NCOR1_26117541_ChIP-Seq_K562_Human0.91865010
155* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91854508
156CLOCK_20551151_ChIP-Seq_293T_Human0.91127246
157GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90488996
158VDR_24763502_ChIP-Seq_THP-1_Human0.89522045
159GABP_17652178_ChIP-ChIP_JURKAT_Human0.88808738

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.48987291
2MP0003656_abnormal_erythrocyte_physiolo3.33084551
3MP0008004_abnormal_stomach_pH3.03910740
4MP0003693_abnormal_embryo_hatching2.91573455
5MP0004957_abnormal_blastocyst_morpholog2.61299576
6MP0003300_gastrointestinal_ulcer2.42768916
7MP0010094_abnormal_chromosome_stability2.36823269
8MP0006054_spinal_hemorrhage2.34991467
9MP0003111_abnormal_nucleus_morphology2.34220804
10MP0002396_abnormal_hematopoietic_system2.32393986
11MP0010307_abnormal_tumor_latency2.26934268
12MP0009697_abnormal_copulation2.21216208
13MP0002877_abnormal_melanocyte_morpholog2.20758307
14MP0003566_abnormal_cell_adhesion2.14316471
15MP0003077_abnormal_cell_cycle2.10438036
16MP0008057_abnormal_DNA_replication2.08986219
17MP0008438_abnormal_cutaneous_collagen2.01586329
18MP0005076_abnormal_cell_differentiation1.95052561
19MP0010234_abnormal_vibrissa_follicle1.88878080
20MP0009278_abnormal_bone_marrow1.88863283
21MP0000490_abnormal_crypts_of1.85393474
22MP0002166_altered_tumor_susceptibility1.81597525
23MP0001661_extended_life_span1.79912464
24MP0004808_abnormal_hematopoietic_stem1.78029338
25MP0004264_abnormal_extraembryonic_tissu1.75484590
26MP0001545_abnormal_hematopoietic_system1.71350273
27MP0005397_hematopoietic_system_phenotyp1.71350273
28MP0004272_abnormal_basement_membrane1.69012673
29MP0003718_maternal_effect1.63369327
30MP0002006_tumorigenesis1.60133829
31MP0003091_abnormal_cell_migration1.57885691
32MP0001730_embryonic_growth_arrest1.56097434
33MP0000350_abnormal_cell_proliferation1.55588672
34MP0003436_decreased_susceptibility_to1.52236092
35MP0002086_abnormal_extraembryonic_tissu1.51285280
36MP0005451_abnormal_body_composition1.48429672
37MP0005310_abnormal_salivary_gland1.47821208
38MP0002234_abnormal_pharynx_morphology1.42046634
39MP0005023_abnormal_wound_healing1.41569584
40MP0003303_peritoneal_inflammation1.40424987
41MP0001672_abnormal_embryogenesis/_devel1.40159018
42MP0005380_embryogenesis_phenotype1.40159018
43MP0008007_abnormal_cellular_replicative1.39499912
44MP0004185_abnormal_adipocyte_glucose1.39004129
45MP0008961_abnormal_basal_metabolism1.37875213
46MP0008058_abnormal_DNA_repair1.37413185
47MP0003984_embryonic_growth_retardation1.36554341
48MP0004084_abnormal_cardiac_muscle1.34707003
49MP0002088_abnormal_embryonic_growth/wei1.33683485
50MP0000858_altered_metastatic_potential1.32863607
51MP0005647_abnormal_sex_gland1.32209762
52MP0001915_intracranial_hemorrhage1.29335686
53MP0008775_abnormal_heart_ventricle1.29053966
54MP0004147_increased_porphyrin_level1.28850956
55MP0005083_abnormal_biliary_tract1.27060901
56MP0002019_abnormal_tumor_incidence1.26254374
57MP0003705_abnormal_hypodermis_morpholog1.26034944
58MP0010368_abnormal_lymphatic_system1.23257971
59MP0005623_abnormal_meninges_morphology1.21335143
60MP0001873_stomach_inflammation1.20373657
61MP0001697_abnormal_embryo_size1.20286242
62MP0002084_abnormal_developmental_patter1.19522230
63MP0009333_abnormal_splenocyte_physiolog1.19271656
64MP0003806_abnormal_nucleotide_metabolis1.18390634
65MP0002928_abnormal_bile_duct1.16881473
66MP0003763_abnormal_thymus_physiology1.16198864
67MP0004858_abnormal_nervous_system1.15307931
68MP0000371_diluted_coat_color1.14286255
69MP0003828_pulmonary_edema1.14115564
70MP0002080_prenatal_lethality1.13526973
71MP0004036_abnormal_muscle_relaxation1.12172053
72MP0002398_abnormal_bone_marrow1.11066614
73MP0002085_abnormal_embryonic_tissue1.10033666
74MP0004197_abnormal_fetal_growth/weight/1.09692336
75MP0000313_abnormal_cell_death1.08496284
76MP0003172_abnormal_lysosome_physiology1.06080178
77MP0001849_ear_inflammation1.05783128
78MP0003448_altered_tumor_morphology1.04808136
79MP0003283_abnormal_digestive_organ1.04583234
80* MP0002722_abnormal_immune_system1.04365416
81MP0001835_abnormal_antigen_presentation1.03621353
82MP0000358_abnormal_cell_content/1.03473892
83MP0005384_cellular_phenotype1.02877203
84MP0002405_respiratory_system_inflammati1.02730272
85* MP0000689_abnormal_spleen_morphology1.01679112
86MP0000230_abnormal_systemic_arterial0.99040476
87MP0004510_myositis0.98864376
88* MP0000703_abnormal_thymus_morphology0.98275615
89* MP0010155_abnormal_intestine_physiology0.97851025
90MP0004134_abnormal_chest_morphology0.96696419
91MP0003453_abnormal_keratinocyte_physiol0.96212844
92MP0005464_abnormal_platelet_physiology0.95737475
93MP0008932_abnormal_embryonic_tissue0.93738313
94MP0004947_skin_inflammation0.92969458
95MP0001800_abnormal_humoral_immune0.92755001
96MP0002452_abnormal_antigen_presenting0.92202375
97MP0002429_abnormal_blood_cell0.92196877
98MP0000685_abnormal_immune_system0.92017504
99MP0003045_fibrosis0.91918004
100MP0002128_abnormal_blood_circulation0.91415331
101MP0005395_other_phenotype0.91055355
102MP0000613_abnormal_salivary_gland0.90089407
103MP0002420_abnormal_adaptive_immunity0.87965161
104MP0001819_abnormal_immune_cell0.87355138
105MP0002925_abnormal_cardiovascular_devel0.86132681
106MP0002419_abnormal_innate_immunity0.85878174
107* MP0000477_abnormal_intestine_morphology0.85617970
108MP0000428_abnormal_craniofacial_morphol0.85434740
109MP0000716_abnormal_immune_system0.85075457
110MP0003950_abnormal_plasma_membrane0.84773041
111MP0005025_abnormal_response_to0.84446336
112MP0002009_preneoplasia0.83911944
113MP0004133_heterotaxia0.83872396
114MP0002736_abnormal_nociception_after0.82712883
115MP0003786_premature_aging0.82564688
116MP0000627_abnormal_mammary_gland0.82548290
117MP0003567_abnormal_fetal_cardiomyocyte0.81776220
118MP0001879_abnormal_lymphatic_vessel0.79897055
119MP0005621_abnormal_cell_physiology0.79660364
120MP0005000_abnormal_immune_tolerance0.79593658
121MP0000733_abnormal_muscle_development0.78540337
122MP0009785_altered_susceptibility_to0.78406931
123MP0001664_abnormal_digestion0.78304875
124MP0009643_abnormal_urine_homeostasis0.78103846
125MP0001853_heart_inflammation0.77583111
126MP0000465_gastrointestinal_hemorrhage0.77548901
127* MP0001845_abnormal_inflammatory_respons0.77376129
128MP0003724_increased_susceptibility_to0.76837716
129MP0002138_abnormal_hepatobiliary_system0.76764086
130MP0003868_abnormal_feces_composition0.76456074
131MP0005187_abnormal_penis_morphology0.76151151
132MP0003890_abnormal_embryonic-extraembry0.74106005
133MP0002723_abnormal_immune_serum0.73491911
134MP0001533_abnormal_skeleton_physiology0.73238203
135MP0005058_abnormal_lysosome_morphology0.73027318
136MP0003186_abnormal_redox_activity0.72053400
137MP0006138_congestive_heart_failure0.71624768
138* MP0002136_abnormal_kidney_physiology0.71536873
139MP0003943_abnormal_hepatobiliary_system0.71229675
140MP0005666_abnormal_adipose_tissue0.71108572
141MP0005409_darkened_coat_color0.70740184
142MP0003941_abnormal_skin_development0.70600891
143MP0001851_eye_inflammation0.70248490
144MP0004233_abnormal_muscle_weight0.69008803
145MP0005164_abnormal_response_to0.68909253
146MP0005220_abnormal_exocrine_pancreas0.67189491
147MP0001542_abnormal_bone_strength0.65226263
148MP0003279_aneurysm0.64251585
149MP0000432_abnormal_head_morphology0.63061072

Predicted human phenotypes

RankGene SetZ-score
1Menorrhagia (HP:0000132)7.37723743
2Prolonged bleeding time (HP:0003010)6.78193028
3Epistaxis (HP:0000421)4.83150144
4Purpura (HP:0000979)4.61430649
5Abnormal platelet function (HP:0011869)4.60513212
6Impaired platelet aggregation (HP:0003540)4.60513212
7Gingival bleeding (HP:0000225)3.87146184
8Aortic aneurysm (HP:0004942)3.85128558
9Poikilocytosis (HP:0004447)3.44186690
10Abnormality of the heme biosynthetic pathway (HP:0010472)3.03447665
11Acanthocytosis (HP:0001927)3.02627253
12Ependymoma (HP:0002888)3.00275272
13Osteolytic defects of the hand bones (HP:0009699)2.99697873
14Osteolytic defects of the phalanges of the hand (HP:0009771)2.99697873
15Premature rupture of membranes (HP:0001788)2.92426418
16Aortic dissection (HP:0002647)2.89351228
17Selective tooth agenesis (HP:0001592)2.85635792
18Thrombocytosis (HP:0001894)2.79818151
19Reticulocytopenia (HP:0001896)2.78149337
20Missing ribs (HP:0000921)2.69406164
2111 pairs of ribs (HP:0000878)2.67644770
22Bruising susceptibility (HP:0000978)2.64267067
23Agnosia (HP:0010524)2.59680262
24Submucous cleft hard palate (HP:0000176)2.58469828
25Spontaneous hematomas (HP:0007420)2.56519741
26Ankyloglossia (HP:0010296)2.54653614
27Short humerus (HP:0005792)2.49594865
28Acute myeloid leukemia (HP:0004808)2.48634291
29Short 1st metacarpal (HP:0010034)2.47702665
30Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.47702665
31Abnormality of the common coagulation pathway (HP:0010990)2.43274520
32Cerebral aneurysm (HP:0004944)2.40531312
33Biliary tract neoplasm (HP:0100574)2.39270541
34Aplasia/hypoplasia of the humerus (HP:0006507)2.38260176
35IgM deficiency (HP:0002850)2.37063159
36Abnormality of chromosome stability (HP:0003220)2.32542928
37Papillary thyroid carcinoma (HP:0002895)2.32423719
38Chromsome breakage (HP:0040012)2.31856565
39Spastic diplegia (HP:0001264)2.28904271
40Prominent nose (HP:0000448)2.27847160
41Colon cancer (HP:0003003)2.27754521
42Deviation of the thumb (HP:0009603)2.26172508
43Malignant gastrointestinal tract tumors (HP:0006749)2.25459357
44Gastrointestinal carcinoma (HP:0002672)2.25459357
45Conjunctival telangiectasia (HP:0000524)2.25141110
46Esophageal varix (HP:0002040)2.23801938
47Autoimmune thrombocytopenia (HP:0001973)2.22975993
48Metaphyseal cupping (HP:0003021)2.21353222
49Abnormality of oral frenula (HP:0000190)2.20193015
50Spinal rigidity (HP:0003306)2.19898821
51Abnormality of the astrocytes (HP:0100707)2.19653861
52Astrocytoma (HP:0009592)2.19653861
53Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.19179942
54Vertebral hypoplasia (HP:0008417)2.19179942
55Myelodysplasia (HP:0002863)2.18002546
56Abnormality of the 1st metacarpal (HP:0010009)2.17749273
57Rhabdomyosarcoma (HP:0002859)2.16028603
58Basal cell carcinoma (HP:0002671)2.15924335
59Abnormal foot bone ossification (HP:0010675)2.15372603
60Amaurosis fugax (HP:0100576)2.14420775
61Spinal muscular atrophy (HP:0007269)2.13679248
62Eczematoid dermatitis (HP:0000976)2.13386740
63Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.11375990
64Interstitial pulmonary disease (HP:0006530)2.09397372
65Hematochezia (HP:0002573)2.09356921
66Overgrowth (HP:0001548)2.09191452
67Proximal placement of thumb (HP:0009623)2.07926927
68Short nail (HP:0001799)2.06516782
69Hand muscle atrophy (HP:0009130)2.05879071
70Ulnar bowing (HP:0003031)2.05697430
71Dysmetric saccades (HP:0000641)2.04182852
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04008109
73Sparse lateral eyebrow (HP:0005338)2.01761017
74Medulloblastoma (HP:0002885)2.01295823
75Protrusio acetabuli (HP:0003179)2.00928859
76Micronodular cirrhosis (HP:0001413)2.00614971
77Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00284449
78Absent thumb (HP:0009777)1.99360524
79Abnormality of T cell physiology (HP:0011840)1.98729981
80Relative macrocephaly (HP:0004482)1.97554945
81Abnormality of the calcaneus (HP:0008364)1.93988504
82Blue sclerae (HP:0000592)1.93002167
83Radial bowing (HP:0002986)1.92787621
84Petechiae (HP:0000967)1.91904414
85Adactyly (HP:0009776)1.91851519
86Cervical subluxation (HP:0003308)1.91128129
87Abnormality of the distal phalanx of the thumb (HP:0009617)1.91069468
88Arterial tortuosity (HP:0005116)1.90892384
89Neoplasm of the oral cavity (HP:0100649)1.90157182
90Polycythemia (HP:0001901)1.89871571
91Vascular tortuosity (HP:0004948)1.89411763
92Recurrent abscess formation (HP:0002722)1.88228626
93Sandal gap (HP:0001852)1.86744226
94Insidious onset (HP:0003587)1.85524685
95Termporal pattern (HP:0011008)1.85524685
96Aplastic anemia (HP:0001915)1.84660195
97Abnormality of the fingertips (HP:0001211)1.84067004
98High pitched voice (HP:0001620)1.83943632
99Uterine neoplasm (HP:0010784)1.83893648
100Abnormality of cells of the erythroid lineage (HP:0012130)1.82862154
101Urinary glycosaminoglycan excretion (HP:0003541)1.82391200
102Mucopolysacchariduria (HP:0008155)1.82391200
103Natal tooth (HP:0000695)1.80677238
104Autoimmune hemolytic anemia (HP:0001890)1.80356103
105Abnormality of the intrinsic pathway (HP:0010989)1.78831064
106Absent radius (HP:0003974)1.78518398
107Elbow flexion contracture (HP:0002987)1.77559606
108Pustule (HP:0200039)1.77550141
109Renal tubular acidosis (HP:0001947)1.77354190
110Hypoglycemic coma (HP:0001325)1.77057212
111Abnormal platelet volume (HP:0011876)1.77032480
112Thyroid carcinoma (HP:0002890)1.76361127
113Trismus (HP:0000211)1.75961411
114Squamous cell carcinoma (HP:0002860)1.75098255
115Abnormality of the acetabulum (HP:0003170)1.74981125
116Abnormality of the anterior horn cell (HP:0006802)1.74621629
117Degeneration of anterior horn cells (HP:0002398)1.74621629
118Persistence of primary teeth (HP:0006335)1.73769309
119Short phalanx of the thumb (HP:0009660)1.73746132
120IgA deficiency (HP:0002720)1.73650632
121Glioma (HP:0009733)1.73525845
122Short middle phalanx of the 5th finger (HP:0004220)1.72823221
123Abnormal umbilical cord blood vessels (HP:0011403)1.72667722
124Single umbilical artery (HP:0001195)1.72667722
125Abnormality of the fetal cardiovascular system (HP:0010948)1.72667722
126Ankle contracture (HP:0006466)1.72300180
127Increased mean platelet volume (HP:0011877)1.71937097
128Recurrent viral infections (HP:0004429)1.71881753
129Abnormality of polysaccharide metabolism (HP:0011012)1.71584584
130Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71584584
131Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71584584
132Leukopenia (HP:0001882)1.71341976
133Seborrheic dermatitis (HP:0001051)1.70004815
134Spondylolisthesis (HP:0003302)1.69980900
135Broad face (HP:0000283)1.69473602
136Abnormality of the phalanges of the hallux (HP:0010057)1.68593425
137Advanced eruption of teeth (HP:0006288)1.68504309
138Wormian bones (HP:0002645)1.68479965
139Carpal bone hypoplasia (HP:0001498)1.68463010
140Subacute progressive viral hepatitis (HP:0006572)1.68306061
141Abnormal hemoglobin (HP:0011902)1.68250534
142Delayed puberty (HP:0000823)1.67020851
143Long toe (HP:0010511)1.66938138
144Urethral obstruction (HP:0000796)1.66653002
145Hyperinsulinemic hypoglycemia (HP:0000825)1.64960977
146Duodenal stenosis (HP:0100867)1.64875885
147Small intestinal stenosis (HP:0012848)1.64875885
148Complete atrioventricular canal defect (HP:0001674)1.64850549
149Abnormality of the Achilles tendon (HP:0005109)1.64097120
150Abnormal ossification of hand bones (HP:0005921)1.63845507
151Abnormal biliary tract morphology (HP:0012440)1.63819376
152Abnormality of the distal phalanges of the toes (HP:0010182)1.63409531
153Ascites (HP:0001541)1.63047668
154Aplasia involving forearm bones (HP:0009822)1.63017289
155Absent forearm bone (HP:0003953)1.63017289
156Flat acetabular roof (HP:0003180)1.62893934
157Abnormal number of erythroid precursors (HP:0012131)1.62876215
158Disproportionate tall stature (HP:0001519)1.62729909
159Abnormal number of incisors (HP:0011064)1.61761143
160Bicuspid aortic valve (HP:0001647)1.60692885
161Lymphoma (HP:0002665)1.60307468
162Abnormality of carpal bone ossification (HP:0006257)1.59349333
163Thoracolumbar scoliosis (HP:0002944)1.58999808
164Vertebral arch anomaly (HP:0008438)1.58101238
165Reticulocytosis (HP:0001923)1.58087530
166Volvulus (HP:0002580)1.57947521
167Stenosis of the external auditory canal (HP:0000402)1.57774951
168Abnormality of the nasal mucosa (HP:0000433)1.57757203
169Abnormal spermatogenesis (HP:0008669)1.56673790
170Neonatal death (HP:0003811)1.56509271
171Abnormality of the umbilical cord (HP:0010881)1.55600277
172Anal stenosis (HP:0002025)1.53974483
173Long eyelashes (HP:0000527)1.53302393
174Hyperthyroidism (HP:0000836)1.53260598
175Congenital hip dislocation (HP:0001374)1.50385494
176Severe short stature (HP:0003510)1.50081606
177Azoospermia (HP:0000027)1.49896361
178Aneurysm (HP:0002617)1.49837929
179Prostate neoplasm (HP:0100787)1.49597501
180Increased density of long bones (HP:0006392)1.48635506
181Abnormal hand bone ossification (HP:0010660)1.48417218
182Decreased skull ossification (HP:0004331)1.48287632
183Upper limb muscle weakness (HP:0003484)1.48036660

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT34.98823737
2EPHA24.34971160
3CAMK1G3.45100827
4CDK123.44624330
5MYLK2.67194097
6STK102.32765797
7RPS6KB22.29363050
8CDC72.29334318
9EEF2K2.28918574
10FLT32.02774429
11TTK1.95041429
12KDR1.93965063
13TIE11.91945698
14TTN1.89764336
15PKN21.88347913
16NEK91.87976043
17NEK11.85229924
18ERN11.81704163
19SCYL21.79337405
20WEE11.79216310
21PAK41.76465715
22NEK21.72457042
23PASK1.70277510
24MST41.57479466
25LRRK21.55435573
26TGFBR21.53985807
27CDK71.43904011
28MAP4K11.43772635
29TGFBR11.42355080
30PIM11.39859730
31RIPK41.38789903
32PIK3CG1.32975108
33MAP3K101.31344901
34MAP3K81.26304561
35CDK61.22556839
36TEC1.21949946
37CDK41.20282606
38STK391.19264816
39PTK61.17564086
40TAOK31.17207161
41CDK81.16393971
42ICK1.15645866
43AURKB1.14565074
44BUB11.12153327
45TSSK61.12015889
46MAPKAPK31.09731130
47SMG11.09409198
48ATR1.08166186
49STK41.07838360
50BMX1.07787245
51EIF2AK31.06370848
52RPS6KA41.05638462
53JAK31.04358521
54WNK11.02382827
55IRAK31.01224306
56RIPK11.00206722
57MTOR0.99645578
58PBK0.99211705
59MAP2K30.98941460
60RAF10.93100990
61CSK0.92547694
62STK30.91937218
63PLK10.91330120
64FER0.88550292
65ILK0.88012484
66BRSK20.87628970
67MAP3K30.86779581
68NME20.86500078
69BCKDK0.85489649
70TRIB30.85207327
71TYK20.84253177
72ALK0.83816458
73ZAP700.83780636
74PIM20.83350939
75TRPM70.82753390
76BTK0.82404668
77CHEK10.81982686
78PTK2B0.81135891
79BRD40.80792661
80ITK0.79168589
81CAMK1D0.78621189
82ERBB40.77847502
83PRKCI0.77499437
84ACVR1B0.76353873
85GRK50.74070174
86CHUK0.73535677
87MATK0.72924604
88DMPK0.72661559
89PNCK0.71650523
90GRK60.68667241
91PDGFRA0.67997764
92PRKG20.67722238
93PTK20.66699685
94EIF2AK20.65448153
95YES10.65406455
96TAOK10.64938423
97STK38L0.64646143
98PRKD20.64215705
99WNK40.63833898
100JAK10.63598539
101PDGFRB0.63040597
102TNK20.62813847
103EIF2AK10.62787487
104PRKAA20.60331703
105MAP3K140.60102669
106ATM0.59649428
107DYRK30.59264019
108STK380.58900392
109MAP3K130.57585439
110IRAK40.56368427
111PAK20.55688968
112MAPK110.55565863
113SGK20.55143683
114MET0.54811988
115CHEK20.54054343
116LATS10.53714370
117TAOK20.53706589
118CDK20.51312116
119NUAK10.49852745
120GSK3A0.49823311
121TESK10.48756161
122FGFR30.48538781
123SGK30.48344346
124BMPR20.47548233
125SRPK10.47393831
126AKT20.46973050
127CLK10.46955329
128BRAF0.46606403
129HIPK20.45850961
130EGFR0.45585554
131CDC42BPA0.45438578
132CDK90.45320961
133CSF1R0.43302512
134AURKA0.42024555
135DYRK1B0.41157379
136MAP2K20.41073040
137STK240.39868902
138MAPK150.39481107
139FGFR40.39067625
140MST1R0.38916437
141DAPK30.38528245
142NLK0.38361648
143IKBKB0.38150371
144MAP2K10.37802707
145PAK10.37190459
146IRAK10.36318501
147HCK0.35411596
148MELK0.35353481

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.46119516
2Mismatch repair_Homo sapiens_hsa034302.92073967
3One carbon pool by folate_Homo sapiens_hsa006702.59518962
4Fatty acid biosynthesis_Homo sapiens_hsa000612.46596500
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.36034166
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25100599
7RNA transport_Homo sapiens_hsa030132.02071645
8Homologous recombination_Homo sapiens_hsa034401.96347847
9Base excision repair_Homo sapiens_hsa034101.90282042
10Cell cycle_Homo sapiens_hsa041101.88350994
11Small cell lung cancer_Homo sapiens_hsa052221.73435033
12Spliceosome_Homo sapiens_hsa030401.71365307
13p53 signaling pathway_Homo sapiens_hsa041151.68310811
14Antigen processing and presentation_Homo sapiens_hsa046121.62095501
15Ribosome_Homo sapiens_hsa030101.53462254
16Fanconi anemia pathway_Homo sapiens_hsa034601.47293688
17Nucleotide excision repair_Homo sapiens_hsa034201.45641403
18Non-small cell lung cancer_Homo sapiens_hsa052231.43071820
19Adherens junction_Homo sapiens_hsa045201.41791211
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37105882
21Non-homologous end-joining_Homo sapiens_hsa034501.34025981
22Leishmaniasis_Homo sapiens_hsa051401.33898738
23Selenocompound metabolism_Homo sapiens_hsa004501.32575391
24Viral carcinogenesis_Homo sapiens_hsa052031.32482653
25Herpes simplex infection_Homo sapiens_hsa051681.30291537
26Other glycan degradation_Homo sapiens_hsa005111.24962158
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.24266111
28Leukocyte transendothelial migration_Homo sapiens_hsa046701.21785081
29Thyroid cancer_Homo sapiens_hsa052161.20832695
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.20190033
31Hematopoietic cell lineage_Homo sapiens_hsa046401.19939104
32Chronic myeloid leukemia_Homo sapiens_hsa052201.19671265
33MicroRNAs in cancer_Homo sapiens_hsa052061.19362296
34Legionellosis_Homo sapiens_hsa051341.17895994
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.16764509
36RNA degradation_Homo sapiens_hsa030181.15013463
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14884637
38Apoptosis_Homo sapiens_hsa042101.14282742
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13356855
40Melanoma_Homo sapiens_hsa052181.07668043
41mRNA surveillance pathway_Homo sapiens_hsa030151.02812165
42HTLV-I infection_Homo sapiens_hsa051661.02226693
43Systemic lupus erythematosus_Homo sapiens_hsa053221.01119577
44Alcoholism_Homo sapiens_hsa050340.99985989
45Glioma_Homo sapiens_hsa052140.99241679
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97736826
47Toxoplasmosis_Homo sapiens_hsa051450.97643745
48Notch signaling pathway_Homo sapiens_hsa043300.97472495
49Pyrimidine metabolism_Homo sapiens_hsa002400.95519649
50Gap junction_Homo sapiens_hsa045400.94205671
51Endometrial cancer_Homo sapiens_hsa052130.93877829
52Measles_Homo sapiens_hsa051620.93357253
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90873576
54Shigellosis_Homo sapiens_hsa051310.90055108
55N-Glycan biosynthesis_Homo sapiens_hsa005100.88952305
56Renal cell carcinoma_Homo sapiens_hsa052110.88333021
57Vascular smooth muscle contraction_Homo sapiens_hsa042700.87665506
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86970657
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85419271
60Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85244910
61Acute myeloid leukemia_Homo sapiens_hsa052210.84304576
62Epstein-Barr virus infection_Homo sapiens_hsa051690.83225882
63Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.83195331
64Hepatitis B_Homo sapiens_hsa051610.82809900
65Bladder cancer_Homo sapiens_hsa052190.80831861
66Focal adhesion_Homo sapiens_hsa045100.80722162
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79785895
68Proteoglycans in cancer_Homo sapiens_hsa052050.79739818
69Viral myocarditis_Homo sapiens_hsa054160.79614490
70Influenza A_Homo sapiens_hsa051640.79472458
71AMPK signaling pathway_Homo sapiens_hsa041520.78204285
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77620760
73Inositol phosphate metabolism_Homo sapiens_hsa005620.77138122
74Pentose phosphate pathway_Homo sapiens_hsa000300.77106582
75Lysine degradation_Homo sapiens_hsa003100.76929051
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76833344
77HIF-1 signaling pathway_Homo sapiens_hsa040660.76796145
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75708301
79Fatty acid metabolism_Homo sapiens_hsa012120.74642577
80Osteoclast differentiation_Homo sapiens_hsa043800.74605050
81Colorectal cancer_Homo sapiens_hsa052100.74316925
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.74183604
83TNF signaling pathway_Homo sapiens_hsa046680.73183810
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.72670913
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.71066639
86TGF-beta signaling pathway_Homo sapiens_hsa043500.69729386
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.68941666
88Pancreatic cancer_Homo sapiens_hsa052120.68591379
89mTOR signaling pathway_Homo sapiens_hsa041500.68185844
90Glutathione metabolism_Homo sapiens_hsa004800.68176895
91ECM-receptor interaction_Homo sapiens_hsa045120.66163678
92B cell receptor signaling pathway_Homo sapiens_hsa046620.66140589
93RNA polymerase_Homo sapiens_hsa030200.65958660
94Lysosome_Homo sapiens_hsa041420.65666523
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.65069838
96Primary immunodeficiency_Homo sapiens_hsa053400.64785947
97Propanoate metabolism_Homo sapiens_hsa006400.63739412
98NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63643984
99Choline metabolism in cancer_Homo sapiens_hsa052310.62264362
100Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61733900
101Prostate cancer_Homo sapiens_hsa052150.60970310
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60561016
103Pathways in cancer_Homo sapiens_hsa052000.60410313
104Endocytosis_Homo sapiens_hsa041440.59949221
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.59414026
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59233702
107Tuberculosis_Homo sapiens_hsa051520.58073262
108Platelet activation_Homo sapiens_hsa046110.57183126
109ErbB signaling pathway_Homo sapiens_hsa040120.56218798
110Amoebiasis_Homo sapiens_hsa051460.55407910
111Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54697522
112Hepatitis C_Homo sapiens_hsa051600.54015780
113Insulin signaling pathway_Homo sapiens_hsa049100.53952081
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53574691
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53435199
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.53262209
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53260057
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52676779
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51783518
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51561139
121Galactose metabolism_Homo sapiens_hsa000520.51169888
122Insulin resistance_Homo sapiens_hsa049310.51104181
123Hippo signaling pathway_Homo sapiens_hsa043900.50614253
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.50093647
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49853584
126VEGF signaling pathway_Homo sapiens_hsa043700.49199132
127Oocyte meiosis_Homo sapiens_hsa041140.48962744
128Biosynthesis of amino acids_Homo sapiens_hsa012300.48943976
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.48149367
130Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47420433
131Pertussis_Homo sapiens_hsa051330.47030210
132FoxO signaling pathway_Homo sapiens_hsa040680.46908579
133Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46357210
134Basal transcription factors_Homo sapiens_hsa030220.45003460
135Renin-angiotensin system_Homo sapiens_hsa046140.43175578
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40983904
137Drug metabolism - other enzymes_Homo sapiens_hsa009830.39751149

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