ABCC6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exogenous drug catabolic process (GO:0042738)7.99513530
2L-phenylalanine catabolic process (GO:0006559)7.61064597
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.61064597
4L-phenylalanine metabolic process (GO:0006558)7.26566154
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.26566154
6aromatic amino acid family catabolic process (GO:0009074)6.85986052
7epoxygenase P450 pathway (GO:0019373)6.65500475
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.33760193
9tryptophan catabolic process (GO:0006569)6.25798160
10indole-containing compound catabolic process (GO:0042436)6.25798160
11indolalkylamine catabolic process (GO:0046218)6.25798160
12kynurenine metabolic process (GO:0070189)6.13276021
13omega-hydroxylase P450 pathway (GO:0097267)6.02160540
14bile acid biosynthetic process (GO:0006699)5.97371740
15tryptophan metabolic process (GO:0006568)5.88100541
16glyoxylate metabolic process (GO:0046487)5.75110128
17urea metabolic process (GO:0019627)5.64310907
18urea cycle (GO:0000050)5.64310907
19alpha-linolenic acid metabolic process (GO:0036109)5.63520301
20negative regulation of fibrinolysis (GO:0051918)5.60864175
21high-density lipoprotein particle remodeling (GO:0034375)5.55907119
22regulation of fibrinolysis (GO:0051917)5.45412602
23peptidyl-glutamic acid carboxylation (GO:0017187)5.40952863
24protein carboxylation (GO:0018214)5.40952863
25regulation of protein activation cascade (GO:2000257)5.36428282
26complement activation, alternative pathway (GO:0006957)5.30882378
27cysteine metabolic process (GO:0006534)5.28999960
28sulfur amino acid catabolic process (GO:0000098)5.26818688
29intestinal cholesterol absorption (GO:0030299)5.21781066
30nitrogen cycle metabolic process (GO:0071941)5.18447080
31bile acid metabolic process (GO:0008206)5.11821596
32serine family amino acid catabolic process (GO:0009071)5.11388154
33drug metabolic process (GO:0017144)5.02882196
34regulation of complement activation (GO:0030449)5.00024041
35aromatic amino acid family metabolic process (GO:0009072)4.97833530
36fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.88848778
37regulation of cholesterol esterification (GO:0010872)4.88670854
38regulation of plasminogen activation (GO:0010755)4.86352344
39reverse cholesterol transport (GO:0043691)4.83648333
40tyrosine metabolic process (GO:0006570)4.78729243
41regulation of triglyceride catabolic process (GO:0010896)4.77929746
42protein-lipid complex remodeling (GO:0034368)4.76077080
43macromolecular complex remodeling (GO:0034367)4.76077080
44plasma lipoprotein particle remodeling (GO:0034369)4.76077080
45oxidative demethylation (GO:0070989)4.72783423
46homocysteine metabolic process (GO:0050667)4.72610906
47alpha-amino acid catabolic process (GO:1901606)4.66296006
48acylglycerol homeostasis (GO:0055090)4.63578930
49triglyceride homeostasis (GO:0070328)4.63578930
50negative regulation of sterol transport (GO:0032372)4.63209308
51negative regulation of cholesterol transport (GO:0032375)4.63209308
52phospholipid efflux (GO:0033700)4.58696134
53lysine catabolic process (GO:0006554)4.58337319
54lysine metabolic process (GO:0006553)4.58337319
55ethanol metabolic process (GO:0006067)4.57562602
56amino-acid betaine metabolic process (GO:0006577)4.55693165
57imidazole-containing compound metabolic process (GO:0052803)4.49211664
58coenzyme catabolic process (GO:0009109)4.44911965
59cellular ketone body metabolic process (GO:0046950)4.43862316
60bile acid and bile salt transport (GO:0015721)4.43617957
61indolalkylamine metabolic process (GO:0006586)4.42660177
62glycine metabolic process (GO:0006544)4.41856853
63plasma lipoprotein particle clearance (GO:0034381)4.36516559
64negative regulation of blood coagulation (GO:0030195)4.36132764
65negative regulation of hemostasis (GO:1900047)4.36132764
66cellular biogenic amine catabolic process (GO:0042402)4.34557303
67amine catabolic process (GO:0009310)4.34557303
68glutamate metabolic process (GO:0006536)4.31155605
69cellular amino acid catabolic process (GO:0009063)4.27695314
70cellular glucuronidation (GO:0052695)4.27127815
71cholesterol efflux (GO:0033344)4.25341301
72negative regulation of protein activation cascade (GO:2000258)4.23755736
73benzene-containing compound metabolic process (GO:0042537)4.17160008
74serine family amino acid metabolic process (GO:0009069)4.16347735
75ethanol oxidation (GO:0006069)4.13368457
76cellular modified amino acid catabolic process (GO:0042219)4.08174643
77phenylpropanoid metabolic process (GO:0009698)4.05198521
78drug catabolic process (GO:0042737)4.03787836
79regulation of humoral immune response (GO:0002920)4.03638953
80fibrinolysis (GO:0042730)4.02815322
81dicarboxylic acid biosynthetic process (GO:0043650)4.02730350
82low-density lipoprotein particle remodeling (GO:0034374)4.02098602
83plasma lipoprotein particle assembly (GO:0034377)4.02043057
84arginine metabolic process (GO:0006525)4.01489820
85serine family amino acid biosynthetic process (GO:0009070)4.00603786
86negative regulation of coagulation (GO:0050819)3.99396035
87flavonoid metabolic process (GO:0009812)3.97006281
88aldehyde catabolic process (GO:0046185)3.95351913
89alkaloid metabolic process (GO:0009820)3.92819517
90S-adenosylmethionine metabolic process (GO:0046500)3.91137883
91positive regulation of hemostasis (GO:1900048)3.88576893
92positive regulation of blood coagulation (GO:0030194)3.88576893
93regulation of bile acid biosynthetic process (GO:0070857)3.86712855
94blood coagulation, intrinsic pathway (GO:0007597)3.85958969
95acute-phase response (GO:0006953)3.84321936
96ketone body metabolic process (GO:1902224)3.84136318
97cofactor catabolic process (GO:0051187)3.82186067
98very-low-density lipoprotein particle assembly (GO:0034379)3.80485372
99negative regulation of wound healing (GO:0061045)3.79405493
100complement activation, classical pathway (GO:0006958)3.79079067
101uronic acid metabolic process (GO:0006063)3.78755593
102glucuronate metabolic process (GO:0019585)3.78755593
103protein-lipid complex subunit organization (GO:0071825)3.78400903
104regulation of cholesterol homeostasis (GO:2000188)3.77484891
105positive regulation of lipoprotein lipase activity (GO:0051006)3.76463282
106positive regulation of triglyceride lipase activity (GO:0061365)3.76463282
107cholesterol homeostasis (GO:0042632)3.75071497
108complement activation (GO:0006956)3.74001444
109phospholipid homeostasis (GO:0055091)3.73554366
110protein activation cascade (GO:0072376)3.73248789
111positive regulation of lipid catabolic process (GO:0050996)3.72904988
112carboxylic acid catabolic process (GO:0046395)3.72693599
113organic acid catabolic process (GO:0016054)3.72693599
114negative regulation of lipase activity (GO:0060192)3.72226326
115regulation of apoptotic cell clearance (GO:2000425)3.71636421
116sterol homeostasis (GO:0055092)3.68971771
117short-chain fatty acid metabolic process (GO:0046459)3.68152618
118acetyl-CoA metabolic process (GO:0006084)3.67013757
119cytolysis (GO:0019835)3.63628371
120plasma lipoprotein particle organization (GO:0071827)3.62644190
121fat-soluble vitamin biosynthetic process (GO:0042362)3.60802013
122protein-lipid complex assembly (GO:0065005)3.60117066
123NAD biosynthetic process (GO:0009435)3.59047082
124opsonization (GO:0008228)3.58411776
125positive regulation of coagulation (GO:0050820)3.58173499
126intestinal absorption (GO:0050892)3.58079733
127negative regulation of complement activation (GO:0045916)3.50720680
128positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.45361519
129positive regulation of fatty acid biosynthetic process (GO:0045723)3.44553705
130heme transport (GO:0015886)3.43448778
131lipoprotein metabolic process (GO:0042157)3.41908530
132drug transmembrane transport (GO:0006855)3.33929083

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.41582101
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.22525388
3EGR1_23403033_ChIP-Seq_LIVER_Mouse7.02436305
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.51413121
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.32628716
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.06929915
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.77765282
8* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.01519194
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.99125561
10TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.05427698
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9675230
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92482508
13* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.92098174
14CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.86253871
15ZNF274_21170338_ChIP-Seq_K562_Hela1.71821195
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61919963
17* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60912716
18VDR_22108803_ChIP-Seq_LS180_Human1.58584745
19HTT_18923047_ChIP-ChIP_STHdh_Human1.56178362
20CLOCK_20551151_ChIP-Seq_293T_Human1.52515090
21* HNF4A_19822575_ChIP-Seq_HepG2_Human1.40959735
22GATA1_22025678_ChIP-Seq_K562_Human1.40515321
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39292307
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32537030
25ER_23166858_ChIP-Seq_MCF-7_Human1.22655577
26GBX2_23144817_ChIP-Seq_PC3_Human1.21817298
27RXRA_24833708_ChIP-Seq_LIVER_Mouse1.19826592
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.17987262
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16181796
30PIAS1_25552417_ChIP-Seq_VCAP_Human1.16063405
31IGF1R_20145208_ChIP-Seq_DFB_Human1.10297869
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.09121262
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07317261
34ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05839151
35ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04346994
36ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02726644
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02502972
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01797092
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01267265
40STAT3_23295773_ChIP-Seq_U87_Human1.01126063
41DROSHA_22980978_ChIP-Seq_HELA_Human1.00678195
42MYC_19829295_ChIP-Seq_ESCs_Human0.99666971
43TP53_16413492_ChIP-PET_HCT116_Human0.99577915
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98854050
45PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98402257
46RAC3_21632823_ChIP-Seq_H3396_Human0.97761672
47NFE2_27457419_Chip-Seq_LIVER_Mouse0.97631983
48TCF4_22108803_ChIP-Seq_LS180_Human0.96567437
49TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95601082
50FOXA1_25329375_ChIP-Seq_VCAP_Human0.95479169
51FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95479169
52SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94100710
53KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93925577
54SOX2_19829295_ChIP-Seq_ESCs_Human0.93333430
55NANOG_19829295_ChIP-Seq_ESCs_Human0.93333430
56ERA_21632823_ChIP-Seq_H3396_Human0.93288999
57FLI1_27457419_Chip-Seq_LIVER_Mouse0.92883184
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91714436
59* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91254505
60OCT4_20526341_ChIP-Seq_ESCs_Human0.91158605
61IRF1_19129219_ChIP-ChIP_H3396_Human0.90836295
62FOXA1_21572438_ChIP-Seq_LNCaP_Human0.90724558
63CDX2_19796622_ChIP-Seq_MESCs_Mouse0.90245324
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87860091
65* TCF4_23295773_ChIP-Seq_U87_Human0.87636715
66NANOG_20526341_ChIP-Seq_ESCs_Human0.87416016
67GATA3_21878914_ChIP-Seq_MCF-7_Human0.86855141
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.86675382
69EZH2_27294783_Chip-Seq_NPCs_Mouse0.86335106
70SUZ12_27294783_Chip-Seq_NPCs_Mouse0.86218831
71CBP_20019798_ChIP-Seq_JUKART_Human0.86000894
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.86000894
73RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84968204
74TCF4_18268006_ChIP-ChIP_LS174T_Human0.84881851
75EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.84840082
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.84266254
77* NCOR_22424771_ChIP-Seq_293T_Human0.83221490
78IRF8_22096565_ChIP-ChIP_GC-B_Human0.83131831
79SOX2_21211035_ChIP-Seq_LN229_Human0.82353929
80GATA4_25053715_ChIP-Seq_YYC3_Human0.81539160
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81310907
82SMAD4_21741376_ChIP-Seq_EPCs_Human0.80833109
83ZFP57_27257070_Chip-Seq_ESCs_Mouse0.79428214
84* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78492293
85* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.78087185
86CRX_20693478_ChIP-Seq_RETINA_Mouse0.77389456
87ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77324631
88EZH2_22144423_ChIP-Seq_EOC_Human0.76017130
89TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75270386
90SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75048903
91* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.75022336
92FOXH1_21741376_ChIP-Seq_ESCs_Human0.74926100
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.73851575
94ZNF263_19887448_ChIP-Seq_K562_Human0.73812291
95AR_25329375_ChIP-Seq_VCAP_Human0.73745582
96* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.72382324
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71019194
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.70487711
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.69099058
100* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.67875103
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.67757362
102NRF2_20460467_ChIP-Seq_MEFs_Mouse0.63476606
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.63476606
104RARB_24833708_ChIP-Seq_LIVER_Mouse0.63247091
105* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62776202
106RAD21_21589869_ChIP-Seq_MESCs_Mouse0.61356081
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61102675
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.60986472
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.60864650
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.59666013
111* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.58902527
112CEBPB_22108803_ChIP-Seq_LS180_Human0.56936701
113LXR_22292898_ChIP-Seq_THP-1_Human0.55953520
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.53845157
115FOXA1_25552417_ChIP-Seq_VCAP_Human0.53261383
116MYC_19915707_ChIP-ChIP_AK7_Human0.52009951
117EGR1_19032775_ChIP-ChIP_M12_Human0.51966923
118FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51054171
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50747351
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50497085
121AR_20517297_ChIP-Seq_VCAP_Human0.50295372
122ESET_19884257_ChIP-Seq_ESCs_Mouse0.48973803
123STAT1_17558387_ChIP-Seq_HELA_Human0.48404890
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.48170945
125CBP_21632823_ChIP-Seq_H3396_Human0.47640293
126P53_21459846_ChIP-Seq_SAOS-2_Human0.46642169
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.46396519
128ESR1_21235772_ChIP-Seq_MCF-7_Human0.46057806
129TAF15_26573619_Chip-Seq_HEK293_Human0.44962189
130PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.44932357
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.44876664
132GATA1_19941826_ChIP-Seq_K562_Human0.44221061
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.43013575
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.42833660
135SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42232784
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41946331
137TAF2_19829295_ChIP-Seq_ESCs_Human0.41280128
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.41199842
139GATA6_25053715_ChIP-Seq_YYC3_Human0.40941857
140ERG_21242973_ChIP-ChIP_JURKAT_Human0.40724726
141GATA2_19941826_ChIP-Seq_K562_Human0.40574114
142CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.40550380
143ESR1_20079471_ChIP-ChIP_T-47D_Human0.40221709
144PPAR_26484153_Chip-Seq_NCI-H1993_Human0.40156453
145BCAT_22108803_ChIP-Seq_LS180_Human0.39302580
146MYC_27129775_Chip-Seq_CORNEA_Mouse0.38842747
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.38763798
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.38504221
149LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.35596595
150SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.35414721
151SPI1_26923725_Chip-Seq_HPCs_Mouse0.35122934
152FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.34940870
153CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.34123477
154FOXH1_21741376_ChIP-Seq_EPCs_Human0.33726472
155CDX2_22108803_ChIP-Seq_LS180_Human0.32877921
156SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.32712137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.41680108
2MP0005360_urolithiasis7.64796199
3MP0005085_abnormal_gallbladder_physiolo6.54121837
4MP0005365_abnormal_bile_salt6.22704526
5MP0008875_abnormal_xenobiotic_pharmacok5.22718210
6MP0003806_abnormal_nucleotide_metabolis4.29112912
7MP0003252_abnormal_bile_duct3.97441968
8* MP0010329_abnormal_lipoprotein_level3.51469041
9MP0009840_abnormal_foam_cell3.30540515
10MP0005083_abnormal_biliary_tract3.16427402
11* MP0005332_abnormal_amino_acid2.67595520
12MP0001666_abnormal_nutrient_absorption2.65945059
13MP0003191_abnormal_cellular_cholesterol2.30864127
14MP0000609_abnormal_liver_physiology2.19106766
15MP0004019_abnormal_vitamin_homeostasis2.14641179
16* MP0002118_abnormal_lipid_homeostasis2.10182891
17MP0002138_abnormal_hepatobiliary_system1.94061488
18MP0003868_abnormal_feces_composition1.89704429
19MP0005319_abnormal_enzyme/_coenzyme1.84272748
20MP0001764_abnormal_homeostasis1.66486321
21MP0009697_abnormal_copulation1.61862486
22MP0005584_abnormal_enzyme/coenzyme_acti1.57310038
23MP0005451_abnormal_body_composition1.45577968
24* MP0003195_calcinosis1.44313968
25MP0003011_delayed_dark_adaptation1.35192790
26MP0003656_abnormal_erythrocyte_physiolo1.26892806
27MP0009643_abnormal_urine_homeostasis1.23756363
28MP0003186_abnormal_redox_activity1.22399776
29MP0000598_abnormal_liver_morphology1.18717638
30MP0005647_abnormal_sex_gland1.18066237
31MP0003705_abnormal_hypodermis_morpholog1.16268844
32MP0004043_abnormal_pH_regulation1.10148681
33MP0000604_amyloidosis1.09321912
34MP0000566_synostosis1.08960084
35MP0002254_reproductive_system_inflammat1.07422114
36MP0009764_decreased_sensitivity_to1.06817926
37MP0003122_maternal_imprinting1.05294125
38MP0009763_increased_sensitivity_to1.02887944
39MP0010368_abnormal_lymphatic_system1.01757476
40MP0003879_abnormal_hair_cell0.97299878
41MP0005551_abnormal_eye_electrophysiolog0.94542683
42MP0005636_abnormal_mineral_homeostasis0.93918017
43MP0001986_abnormal_taste_sensitivity0.89873636
44MP0008469_abnormal_protein_level0.89069233
45* MP0009642_abnormal_blood_homeostasis0.87022443
46MP0005408_hypopigmentation0.86247823
47MP0005084_abnormal_gallbladder_morpholo0.84193449
48MP0006036_abnormal_mitochondrial_physio0.81248878
49MP0005376_homeostasis/metabolism_phenot0.79954089
50MP0002909_abnormal_adrenal_gland0.78999070
51MP0009765_abnormal_xenobiotic_induced0.78649586
52MP0002078_abnormal_glucose_homeostasis0.78634566
53MP0002876_abnormal_thyroid_physiology0.77622710
54MP0005670_abnormal_white_adipose0.76628465
55MP0003183_abnormal_peptide_metabolism0.76369945
56MP0002971_abnormal_brown_adipose0.74814800
57MP0005220_abnormal_exocrine_pancreas0.73631974
58MP0003878_abnormal_ear_physiology0.73337431
59MP0005377_hearing/vestibular/ear_phenot0.73337431
60MP0009780_abnormal_chondrocyte_physiolo0.72965843
61MP0005334_abnormal_fat_pad0.71248198
62MP0003690_abnormal_glial_cell0.68364683
63MP0004130_abnormal_muscle_cell0.67989200
64MP0005535_abnormal_body_temperature0.67953430
65MP0001661_extended_life_span0.67061042
66MP0003329_amyloid_beta_deposits0.66372998
67MP0009053_abnormal_anal_canal0.66070569
68MP0005266_abnormal_metabolism0.65365558
69MP0005646_abnormal_pituitary_gland0.64947678
70MP0003646_muscle_fatigue0.63305345
71MP0000639_abnormal_adrenal_gland0.60300701
72MP0002282_abnormal_trachea_morphology0.59312818
73MP0001756_abnormal_urination0.59149425
74MP0005448_abnormal_energy_balance0.57586130
75MP0002822_catalepsy0.57241332
76MP0006035_abnormal_mitochondrial_morpho0.57190476
77MP0005464_abnormal_platelet_physiology0.53152063
78MP0002089_abnormal_postnatal_growth/wei0.50041597
79MP0002928_abnormal_bile_duct0.48732021
80MP0003718_maternal_effect0.48421673
81MP0003638_abnormal_response/metabolism_0.48325054
82MP0008874_decreased_physiological_sensi0.47810209
83MP0001915_intracranial_hemorrhage0.47355957
84MP0001501_abnormal_sleep_pattern0.47315499
85MP0005410_abnormal_fertilization0.45838430
86MP0003724_increased_susceptibility_to0.45534349
87MP0001324_abnormal_eye_pigmentation0.45220801
88MP0003950_abnormal_plasma_membrane0.44374123
89MP0008873_increased_physiological_sensi0.44284046
90MP0004782_abnormal_surfactant_physiolog0.44059209
91MP0003172_abnormal_lysosome_physiology0.43740973
92MP0003436_decreased_susceptibility_to0.43365626
93* MP0002136_abnormal_kidney_physiology0.41670804
94MP0003953_abnormal_hormone_level0.41663207
95MP0003075_altered_response_to0.41365337
96MP0005248_abnormal_Harderian_gland0.40919119
97MP0005379_endocrine/exocrine_gland_phen0.40410502
98MP0004381_abnormal_hair_follicle0.40409518
99MP0005166_decreased_susceptibility_to0.39782468
100MP0000579_abnormal_nail_morphology0.39773470
101MP0008872_abnormal_physiological_respon0.39637861
102MP0002837_dystrophic_cardiac_calcinosis0.39601553
103MP0006292_abnormal_olfactory_placode0.39303483
104MP0004142_abnormal_muscle_tone0.39083340
105MP0004133_heterotaxia0.38893426
106* MP0002168_other_aberrant_phenotype0.37176879
107MP0009672_abnormal_birth_weight0.36839962
108MP0001765_abnormal_ion_homeostasis0.36829957
109MP0001944_abnormal_pancreas_morphology0.36237161
110MP0005666_abnormal_adipose_tissue0.35961983
111* MP0005395_other_phenotype0.35295098
112MP0002796_impaired_skin_barrier0.34585407
113MP0009384_cardiac_valve_regurgitation0.34306275
114MP0009115_abnormal_fat_cell0.33770499
115MP0006082_CNS_inflammation0.33583006
116MP0000249_abnormal_blood_vessel0.32847746
117MP0001243_abnormal_dermal_layer0.32442595
118MP0005058_abnormal_lysosome_morphology0.32283184
119MP0002970_abnormal_white_adipose0.31545448
120MP0000230_abnormal_systemic_arterial0.31212530
121MP0004883_abnormal_blood_vessel0.31023889
122MP0009785_altered_susceptibility_to0.30978080
123MP0001853_heart_inflammation0.29906383
124MP0001881_abnormal_mammary_gland0.28796731
125MP0001845_abnormal_inflammatory_respons0.27124509
126MP0002132_abnormal_respiratory_system0.26685597
127MP0005167_abnormal_blood-brain_barrier0.25247165
128MP0002060_abnormal_skin_morphology0.24593550
129MP0005164_abnormal_response_to0.24396781
130MP0000427_abnormal_hair_cycle0.22812504

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.52844162
2Abnormality of aromatic amino acid family metabolism (HP:0004338)7.51015298
3Intrahepatic cholestasis (HP:0001406)7.40088454
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.75028904
5Prolonged partial thromboplastin time (HP:0003645)6.73235232
6Hypobetalipoproteinemia (HP:0003563)6.50280332
7Xanthomatosis (HP:0000991)6.33200047
8Hyperlipoproteinemia (HP:0010980)5.60188615
9Complement deficiency (HP:0004431)5.42685360
10Joint hemorrhage (HP:0005261)4.89129476
11Hypolipoproteinemia (HP:0010981)4.84416547
12Hyperammonemia (HP:0001987)4.61431608
13Epidermoid cyst (HP:0200040)4.60412011
14Abnormality of the common coagulation pathway (HP:0010990)4.54396283
15Hyperglycinemia (HP:0002154)4.51728040
16Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.41782104
17Ketosis (HP:0001946)4.29692098
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.25428393
19Abnormality of methionine metabolism (HP:0010901)4.25234740
20Hypoalphalipoproteinemia (HP:0003233)4.22505469
21Fat malabsorption (HP:0002630)4.19534709
22Abnormality of glutamine family amino acid metabolism (HP:0010902)4.17894691
23Abnormality of aspartate family amino acid metabolism (HP:0010899)4.10027754
24Abnormality of serine family amino acid metabolism (HP:0010894)3.99049921
25Abnormality of glycine metabolism (HP:0010895)3.99049921
26Hyperglycinuria (HP:0003108)3.98886310
27Abnormality of complement system (HP:0005339)3.96178724
28Hypoglycemic coma (HP:0001325)3.90737688
29Conjugated hyperbilirubinemia (HP:0002908)3.88141145
30Abnormality of pyrimidine metabolism (HP:0004353)3.84369709
31Abnormality of the intrinsic pathway (HP:0010989)3.82983560
32Hypercholesterolemia (HP:0003124)3.71621889
33Hyperbilirubinemia (HP:0002904)3.39762962
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.35397040
35Abnormality of fatty-acid metabolism (HP:0004359)3.31670741
36Delayed CNS myelination (HP:0002188)3.17080058
37Spontaneous abortion (HP:0005268)3.14910594
38Steatorrhea (HP:0002570)3.14734907
39Hypochromic microcytic anemia (HP:0004840)3.11376725
40Abnormality of nucleobase metabolism (HP:0010932)3.08955664
41Abnormality of serum amino acid levels (HP:0003112)3.07429188
42Ketoacidosis (HP:0001993)3.05996534
43Hepatocellular carcinoma (HP:0001402)3.01080489
44Skin nodule (HP:0200036)2.81490565
45Systemic lupus erythematosus (HP:0002725)2.78655346
46Metabolic acidosis (HP:0001942)2.77152097
47Abnormality of purine metabolism (HP:0004352)2.71248642
48Osteomalacia (HP:0002749)2.69887238
49Arthropathy (HP:0003040)2.67373879
50Fair hair (HP:0002286)2.63476331
51Acanthocytosis (HP:0001927)2.61931743
52Lethargy (HP:0001254)2.59660613
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.56512789
54Dicarboxylic aciduria (HP:0003215)2.56512789
55Hypoglycemic seizures (HP:0002173)2.56111126
56Glycosuria (HP:0003076)2.55269797
57Abnormality of urine glucose concentration (HP:0011016)2.55269797
58Abnormal gallbladder morphology (HP:0012437)2.52805738
59Glomerulonephritis (HP:0000099)2.48897228
60Cholelithiasis (HP:0001081)2.46950151
61Spastic diplegia (HP:0001264)2.46147587
62Gout (HP:0001997)2.46087964
63Cerebral edema (HP:0002181)2.39181864
64Abnormal gallbladder physiology (HP:0012438)2.38610769
65Cholecystitis (HP:0001082)2.38610769
66Irritability (HP:0000737)2.36939334
67Neonatal onset (HP:0003623)2.36040591
68Potter facies (HP:0002009)2.36006194
69Facial shape deformation (HP:0011334)2.36006194
70Malnutrition (HP:0004395)2.35935976
71Purpura (HP:0000979)2.35317421
72Amyloidosis (HP:0011034)2.33892060
73Recurrent gram-negative bacterial infections (HP:0005420)2.33638169
74* Rickets (HP:0002748)2.27662256
75Gingival bleeding (HP:0000225)2.26340610
76* Hemorrhage of the eye (HP:0011885)2.24830211
77Esophageal varix (HP:0002040)2.24075970
78Late onset (HP:0003584)2.20231011
79Menorrhagia (HP:0000132)2.19713010
80Hypothermia (HP:0002045)2.16763578
81Brushfield spots (HP:0001088)2.16491428
82* Myocardial infarction (HP:0001658)2.15229076
83Sensorimotor neuropathy (HP:0007141)2.14815587
84Pancreatitis (HP:0001733)2.13698939
85Thrombophlebitis (HP:0004418)2.13423251
86Enlarged kidneys (HP:0000105)2.12757970
87Poikilocytosis (HP:0004447)2.10705338
88Bile duct proliferation (HP:0001408)2.10094177
89Abnormal biliary tract physiology (HP:0012439)2.10094177
90Hyperinsulinemic hypoglycemia (HP:0000825)2.08707547
91Vomiting (HP:0002013)2.07389930
92Opisthotonus (HP:0002179)2.07061387
93Pigmentary retinal degeneration (HP:0001146)2.06325248
94Abnormality of the gallbladder (HP:0005264)2.05307894
95Hyperphosphaturia (HP:0003109)2.02715898
96Generalized aminoaciduria (HP:0002909)2.00490551
97Bifid scrotum (HP:0000048)1.98590098
98Abnormality of iron homeostasis (HP:0011031)1.97443097
99Abnormality of transition element cation homeostasis (HP:0011030)1.94723446
100Proximal tubulopathy (HP:0000114)1.93802482
101Abnormality of proline metabolism (HP:0010907)1.89915103
102Hydroxyprolinuria (HP:0003080)1.89915103
103Abnormal cartilage morphology (HP:0002763)1.87301687
104Generalized hypopigmentation of hair (HP:0011358)1.86726810
105Renal cortical cysts (HP:0000803)1.84420206
106Status epilepticus (HP:0002133)1.83568700
107Abnormal enzyme/coenzyme activity (HP:0012379)1.82534404
108Elevated hepatic transaminases (HP:0002910)1.82290597
109Alkalosis (HP:0001948)1.81684760
110Hypochromic anemia (HP:0001931)1.80491059
111Hyperglycemia (HP:0003074)1.80386128
112Reticulocytosis (HP:0001923)1.79432745
113Nephritis (HP:0000123)1.78271964
114Abnormal urine phosphate concentration (HP:0012599)1.77147300
115Reduced antithrombin III activity (HP:0001976)1.75306056
116Abnormality of vitamin metabolism (HP:0100508)1.74277823
117Gangrene (HP:0100758)1.72835139
118Joint swelling (HP:0001386)1.70079746
119Pulmonary embolism (HP:0002204)1.69462937
120Acute hepatic failure (HP:0006554)1.69349467
121Symptomatic seizures (HP:0011145)1.66527319
122Retinal atrophy (HP:0001105)1.65906895
123Hyperuricemia (HP:0002149)1.65053291
124Increased purine levels (HP:0004368)1.65053291
125Cerebral palsy (HP:0100021)1.64847623
126Increased serum ferritin (HP:0003281)1.64845593
127* Vascular calcification (HP:0004934)1.62146009
128Widely patent fontanelles and sutures (HP:0004492)1.55480279
129Neoplasm of the liver (HP:0002896)1.55155036
130Azoospermia (HP:0000027)1.52153673
131Chronic hepatic failure (HP:0100626)1.45131222
132Abnormality of the renal cortex (HP:0011035)1.44365954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.96048262
2FGFR44.75166839
3SIK14.74680211
4ERN14.40261117
5TAOK33.35153130
6WNK43.29203094
7INSRR3.03742087
8ERBB42.94486229
9ACVR1B2.53516157
10ADRBK22.43234604
11MAP2K42.32136564
12PKN22.12992644
13WNK32.09261541
14MST1R2.08395890
15TLK11.88630977
16MAPK111.87761489
17FLT31.84020974
18PIK3CG1.80709605
19TYK21.70665748
20TRIB31.70081450
21DAPK21.68684499
22MAP4K21.68591845
23LATS11.61652972
24MAPKAPK31.57512854
25BMPR1B1.57340216
26PTK61.52120769
27NTRK31.42060686
28ABL21.41139844
29FGFR21.38156514
30KDR1.37119455
31FRK1.35854603
32CAMKK21.30375185
33NEK91.28208248
34JAK21.24069944
35MAP3K71.20578441
36PRKAA21.14929891
37GRK61.08305261
38MAPK151.07384221
39ERBB21.07073805
40CASK1.06697675
41PINK11.06455289
42TBK11.03727148
43STK391.03250812
44MAP2K31.03157211
45JAK11.02710412
46BCR1.00944755
47FER1.00250048
48MAP3K140.98862568
49MAP3K100.98235939
50MAP3K40.97108726
51MAPK40.96963571
52ZAK0.92777543
53PRKCZ0.92563329
54EPHB10.87649071
55NLK0.87621910
56WNK10.87047511
57SIK20.86559559
58OXSR10.86235442
59MET0.83960728
60CDK60.81836792
61STK38L0.81041687
62MAPK120.80795252
63MAP3K30.78812866
64DYRK1B0.78298028
65TIE10.77925310
66EPHA30.77261847
67MAPK130.76303388
68PRKG10.75725671
69MATK0.75347406
70PRKACG0.75062876
71MAP3K110.74998574
72PRKACA0.73506210
73CAMK1D0.72592258
74OBSCN0.72116892
75CSK0.71935421
76TXK0.70517837
77MAP2K60.70408585
78CAMK2G0.69637352
79RIPK10.66975597
80PRKAA10.66620500
81CHUK0.66407856
82GSK3A0.66382085
83IRAK30.64524721
84SGK30.63105236
85EPHA40.60664360
86NUAK10.60508897
87ADRBK10.59798503
88PDK20.59682367
89SGK10.59398429
90PRKCE0.59295881
91MAP3K20.58782876
92TGFBR20.58061225
93PTK20.57973705
94MAPK70.57791767
95FGFR30.55098407
96TNK20.54135299
97CSF1R0.53683432
98IKBKE0.53218485
99FGFR10.52890200
100MAP3K90.52488691
101PDPK10.50983013
102PRKCQ0.50707391
103IKBKB0.50555377
104CSNK1D0.48904929
105CSNK1G10.47175930
106SGK20.46806481
107GRK10.46135142
108TAOK20.45028054
109MAP3K130.44947247
110IGF1R0.43089965
111ICK0.43039983
112BRSK20.42593742
113NME10.42183732
114RET0.41948220
115PKN10.41439334
116MAP3K50.40941192
117MAP2K10.40084338
118STK160.39568052
119CDK40.39479243
120PRKCG0.38875174
121CDK120.38113656
122MTOR0.36658738
123KIT0.35636097
124MAP3K60.35348041
125CSNK1A10.35045579
126STK380.34992189
127CAMK40.33824122
128SGK4940.32699061
129SGK2230.32699061
130EGFR0.32168996
131PDK10.29928718
132MAP3K10.29657118
133CAMK1G0.27756502
134PBK0.27051719
135CSNK1G20.26890613
136PRKCA0.26197310
137PIK3CA0.25276335
138LATS20.24936008
139CSNK1G30.23027715
140IRAK10.22819262
141PAK30.21484115
142IRAK20.21112978
143ABL10.20788262
144MAP2K20.20702960
145AKT30.20585807

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54145311
2Nitrogen metabolism_Homo sapiens_hsa009103.57125593
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.37996709
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.32982842
5Arginine biosynthesis_Homo sapiens_hsa002203.06445119
6Complement and coagulation cascades_Homo sapiens_hsa046102.78656221
7Tryptophan metabolism_Homo sapiens_hsa003802.71299185
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71220982
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63240580
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.54364446
11Fatty acid degradation_Homo sapiens_hsa000712.47236550
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.37296921
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27683896
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16902893
15Butanoate metabolism_Homo sapiens_hsa006502.15636465
16Peroxisome_Homo sapiens_hsa041462.06481974
17Chemical carcinogenesis_Homo sapiens_hsa052041.97263061
18Histidine metabolism_Homo sapiens_hsa003401.95913896
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.94436096
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.93691896
21Propanoate metabolism_Homo sapiens_hsa006401.90260038
22PPAR signaling pathway_Homo sapiens_hsa033201.85929755
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.79488192
24Staphylococcus aureus infection_Homo sapiens_hsa051501.78924088
25Fatty acid metabolism_Homo sapiens_hsa012121.78513574
26Caffeine metabolism_Homo sapiens_hsa002321.75884254
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73780403
28Retinol metabolism_Homo sapiens_hsa008301.72151330
29beta-Alanine metabolism_Homo sapiens_hsa004101.70636579
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65659998
31Selenocompound metabolism_Homo sapiens_hsa004501.59301939
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59138368
33Phenylalanine metabolism_Homo sapiens_hsa003601.54354889
34Bile secretion_Homo sapiens_hsa049761.52513061
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50496803
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47522458
37Tyrosine metabolism_Homo sapiens_hsa003501.44646671
38Pyruvate metabolism_Homo sapiens_hsa006201.35901946
39Sulfur metabolism_Homo sapiens_hsa009201.32649690
40Fatty acid elongation_Homo sapiens_hsa000621.30090991
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29109817
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.28275799
43Folate biosynthesis_Homo sapiens_hsa007901.21583097
44Steroid biosynthesis_Homo sapiens_hsa001001.20423189
45Fat digestion and absorption_Homo sapiens_hsa049751.18161683
46Biosynthesis of amino acids_Homo sapiens_hsa012301.18126699
47Carbon metabolism_Homo sapiens_hsa012001.10336123
48* ABC transporters_Homo sapiens_hsa020101.08842964
49Maturity onset diabetes of the young_Homo sapiens_hsa049501.05578549
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.03170849
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02336198
52Vitamin B6 metabolism_Homo sapiens_hsa007500.98869309
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97774221
54Arginine and proline metabolism_Homo sapiens_hsa003300.96858742
55Sulfur relay system_Homo sapiens_hsa041220.92839688
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86606464
57Vitamin digestion and absorption_Homo sapiens_hsa049770.86180457
58Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85993741
59Lysine degradation_Homo sapiens_hsa003100.82247413
60One carbon pool by folate_Homo sapiens_hsa006700.78255719
61Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69728535
62Glycerolipid metabolism_Homo sapiens_hsa005610.67891490
63Glutathione metabolism_Homo sapiens_hsa004800.64660452
64Pentose phosphate pathway_Homo sapiens_hsa000300.53662740
65Fatty acid biosynthesis_Homo sapiens_hsa000610.52669892
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47411177
67Metabolic pathways_Homo sapiens_hsa011000.45303214
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44567831
69Mineral absorption_Homo sapiens_hsa049780.37069091
70Prion diseases_Homo sapiens_hsa050200.35132157
71Ether lipid metabolism_Homo sapiens_hsa005650.30282778
72Galactose metabolism_Homo sapiens_hsa000520.26566414
73alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26391379
74Pertussis_Homo sapiens_hsa051330.24772167
75Insulin resistance_Homo sapiens_hsa049310.24170135
76Fructose and mannose metabolism_Homo sapiens_hsa000510.22053269
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.21842567
78Linoleic acid metabolism_Homo sapiens_hsa005910.21812580
79Sphingolipid metabolism_Homo sapiens_hsa006000.21508195
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21394570
81Other glycan degradation_Homo sapiens_hsa005110.18988165
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18082673
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.16122973
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.12237118
85Glucagon signaling pathway_Homo sapiens_hsa049220.10627191
86Serotonergic synapse_Homo sapiens_hsa047260.07292314
87Circadian rhythm_Homo sapiens_hsa047100.03551651
88AMPK signaling pathway_Homo sapiens_hsa041520.01935614
89Amoebiasis_Homo sapiens_hsa05146-0.2415550
90Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2363150
91Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2339508
92Bladder cancer_Homo sapiens_hsa05219-0.2251976
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2112075
94Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2109538
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1983032
96Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1883780
97Renin-angiotensin system_Homo sapiens_hsa04614-0.1771542
98Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1733261
99Hepatitis C_Homo sapiens_hsa05160-0.1728701
100Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1581155
101Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1506045
102Regulation of autophagy_Homo sapiens_hsa04140-0.1495666
103Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1449694
104Taste transduction_Homo sapiens_hsa04742-0.1353811
105African trypanosomiasis_Homo sapiens_hsa05143-0.1349163
106N-Glycan biosynthesis_Homo sapiens_hsa00510-0.1278381
107Insulin signaling pathway_Homo sapiens_hsa04910-0.1001649
108Protein digestion and absorption_Homo sapiens_hsa04974-0.0963897
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0865740
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0862553
111Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0608453
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0480514
113Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0462708
114Phototransduction_Homo sapiens_hsa04744-0.0393199
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080-0.0113823

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