ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of fibrinolysis (GO:0051918)	7.93191990
2	regulation of fibrinolysis (GO:0051917)	7.57128963
3	very-low-density lipoprotein particle assembly (GO:0034379)	6.66031293
4	protein carboxylation (GO:0018214)	6.54297607
5	peptidyl-glutamic acid carboxylation (GO:0017187)	6.54297607
6	L-phenylalanine catabolic process (GO:0006559)	6.44574322
7	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	6.44574322
8	regulation of protein activation cascade (GO:2000257)	6.40750700
9	plasma lipoprotein particle assembly (GO:0034377)	6.27213331
10	cholesterol efflux (GO:0033344)	6.13120286
11	regulation of complement activation (GO:0030449)	6.09308951
12	L-phenylalanine metabolic process (GO:0006558)	6.06656844
13	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	6.06656844
14	intestinal cholesterol absorption (GO:0030299)	5.77924419
15	negative regulation of cholesterol transport (GO:0032375)	5.76509462
16	negative regulation of sterol transport (GO:0032372)	5.76509462
17	regulation of cholesterol esterification (GO:0010872)	5.67932853
18	high-density lipoprotein particle remodeling (GO:0034375)	5.56309233
19	macromolecular complex remodeling (GO:0034367)	5.54598625
20	plasma lipoprotein particle remodeling (GO:0034369)	5.54598625
21	protein-lipid complex remodeling (GO:0034368)	5.54598625
22	blood coagulation, intrinsic pathway (GO:0007597)	5.49834365
23	protein-lipid complex assembly (GO:0065005)	5.47088008
24	complement activation, alternative pathway (GO:0006957)	5.31284789
25	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.30669245
26	exogenous drug catabolic process (GO:0042738)	5.25820737
27	phospholipid efflux (GO:0033700)	5.11527440
28	epoxygenase P450 pathway (GO:0019373)	5.04401662
29	fibrinolysis (GO:0042730)	5.01557416
30	reverse cholesterol transport (GO:0043691)	5.00720482
31	regulation of plasminogen activation (GO:0010755)	4.91451862
32	drug catabolic process (GO:0042737)	4.89339566
33	plasma lipoprotein particle organization (GO:0071827)	4.87781951
34	low-density lipoprotein particle remodeling (GO:0034374)	4.77243192
35	negative regulation of lipase activity (GO:0060192)	4.71238605
36	plasma lipoprotein particle clearance (GO:0034381)	4.53859964
37	protein-lipid complex subunit organization (GO:0071825)	4.52527616
38	glyoxylate metabolic process (GO:0046487)	4.52266790
39	cellular glucuronidation (GO:0052695)	4.37587261
40	ethanol oxidation (GO:0006069)	4.34102509
41	triglyceride homeostasis (GO:0070328)	4.29046443
42	acylglycerol homeostasis (GO:0055090)	4.29046443
43	aromatic amino acid family catabolic process (GO:0009074)	4.23601184
44	negative regulation of hemostasis (GO:1900047)	4.21885592
45	negative regulation of blood coagulation (GO:0030195)	4.21885592
46	positive regulation of triglyceride lipase activity (GO:0061365)	4.20599753
47	positive regulation of lipoprotein lipase activity (GO:0051006)	4.20599753
48	intestinal absorption (GO:0050892)	4.19270562
49	regulation of triglyceride catabolic process (GO:0010896)	4.16769940
50	regulation of bile acid biosynthetic process (GO:0070857)	4.16142435
51	omega-hydroxylase P450 pathway (GO:0097267)	4.13105229
52	regulation of apoptotic cell clearance (GO:2000425)	4.12585379
53	uronic acid metabolic process (GO:0006063)	4.11588891
54	glucuronate metabolic process (GO:0019585)	4.11588891
55	urea metabolic process (GO:0019627)	4.10859486
56	bile acid metabolic process (GO:0008206)	4.08756740
57	negative regulation of digestive system process (GO:0060457)	4.07863217
58	regulation of humoral immune response (GO:0002920)	4.06845801
59	regulation of DNA methylation (GO:0044030)	3.99833794
60	regulation of female gonad development (GO:2000194)	3.97416945
61	cholesterol homeostasis (GO:0042632)	3.92360707
62	sterol homeostasis (GO:0055092)	3.87027788
63	sterol transport (GO:0015918)	3.81759972
64	cholesterol transport (GO:0030301)	3.81759972
65	negative regulation of coagulation (GO:0050819)	3.81566143
66	protein activation cascade (GO:0072376)	3.78879008
67	negative regulation of protein activation cascade (GO:2000258)	3.77728182
68	regulation of acrosome reaction (GO:0060046)	3.77664579
69	positive regulation of blood coagulation (GO:0030194)	3.74804007
70	positive regulation of hemostasis (GO:1900048)	3.74804007
71	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.74570300
72	oxidative demethylation (GO:0070989)	3.73941911
73	nitrogen cycle metabolic process (GO:0071941)	3.65724813
74	imidazole-containing compound metabolic process (GO:0052803)	3.65639463
75	serine family amino acid catabolic process (GO:0009071)	3.65464187
76	negative regulation of wound healing (GO:0061045)	3.63458852
77	urea cycle (GO:0000050)	3.62392772
78	positive regulation of fatty acid biosynthetic process (GO:0045723)	3.57802428
79	drug metabolic process (GO:0017144)	3.55600385
80	glutamate metabolic process (GO:0006536)	3.54241090
81	lipoprotein metabolic process (GO:0042157)	3.51023672
82	positive regulation of coagulation (GO:0050820)	3.48587098
83	drinking behavior (GO:0042756)	3.48471187
84	positive regulation of steroid metabolic process (GO:0045940)	3.48350483
85	acute-phase response (GO:0006953)	3.47564226
86	ethanol metabolic process (GO:0006067)	3.45558395
87	bile acid biosynthetic process (GO:0006699)	3.44452144
88	positive regulation of cellular amine metabolic process (GO:0033240)	3.42716599
89	drug transmembrane transport (GO:0006855)	3.36850570
90	regulation of lipoprotein particle clearance (GO:0010984)	3.36138145
91	regulation of cholesterol homeostasis (GO:2000188)	3.35154130
92	complement activation, classical pathway (GO:0006958)	3.34726903
93	glycine metabolic process (GO:0006544)	3.34464456
94	fat-soluble vitamin biosynthetic process (GO:0042362)	3.30775170
95	tyrosine metabolic process (GO:0006570)	3.30303740
96	bile acid and bile salt transport (GO:0015721)	3.25495647
97	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	3.23974125
98	piRNA metabolic process (GO:0034587)	3.16825232
99	lipid homeostasis (GO:0055088)	3.14032381
100	regulation of meiosis I (GO:0060631)	3.10548545

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	9.57712258
2	EZH2_22144423_ChIP-Seq_EOC_Human	6.47589236
3	RXR_22158963_ChIP-Seq_LIVER_Mouse	5.26273082
4	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.66228870
5	LXR_22158963_ChIP-Seq_LIVER_Mouse	4.60395828
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	4.12511680
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.09639846
8	PPARA_22158963_ChIP-Seq_LIVER_Mouse	4.01564421
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.64224743
10	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	3.49023392
11	FOXA2_19822575_ChIP-Seq_HepG2_Human	3.35397692
12	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.31727141
13	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.22407802
14	ESR1_15608294_ChIP-ChIP_MCF-7_Human	2.94143012
15	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.92281619
16	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.85304210
17	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.84853472
18	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.84499491
19	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.67973298
20	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.33879045
21	AR_21909140_ChIP-Seq_LNCAP_Human	2.26295870
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87950967
23	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.86870320
24	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.78336634
25	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.78336634
26	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.78336634
27	GATA4_25053715_ChIP-Seq_YYC3_Human	1.69209484
28	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62686873
29	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.56345326
30	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.53193820
31	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.48030547
32	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.37814582
33	HTT_18923047_ChIP-ChIP_STHdh_Human	1.36649913
34	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.36140556
35	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.30728336
36	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.25811948
37	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.17850006
38	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.17042193
39	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.13643728
40	GATA6_25053715_ChIP-Seq_YYC3_Human	1.08208989
41	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05609821
42	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.02958350
43	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.02922258
44	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.00255406
45	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.98883524
46	CBP_21632823_ChIP-Seq_H3396_Human	0.97566776
47	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	0.97117394
48	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.93491504
49	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.92903152
50	SOX2_21211035_ChIP-Seq_LN229_Human	0.92216897
51	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.92121914
52	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90484657
53	IRF1_19129219_ChIP-ChIP_H3396_Human	0.90412951
54	TP53_16413492_ChIP-PET_HCT116_Human	0.88338911
55	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.87616005
56	AR_20517297_ChIP-Seq_VCAP_Human	0.86728846
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.85195260
58	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.84951301
59	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.82369772
60	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.81510511
61	SOX2_27498859_Chip-Seq_STOMACH_Mouse	0.81493209
62	GBX2_23144817_ChIP-Seq_PC3_Human	0.80230386
63	CEBPB_22108803_ChIP-Seq_LS180_Human	0.79722354
64	CDX2_22108803_ChIP-Seq_LS180_Human	0.78941859
65	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.78460663
66	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.77248003
67	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.75710655
68	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.74870731
69	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.73379113
70	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.72301860
71	TCF4_23295773_ChIP-Seq_U87_Human	0.71876680
72	GF1_26923725_Chip-Seq_HPCs_Mouse	0.71754843
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.70280494
74	RAC3_21632823_ChIP-Seq_H3396_Human	0.70133240
75	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.69762897
76	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.68068802
77	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.67879770
78	STAT3_23295773_ChIP-Seq_U87_Human	0.67344674
79	SOX2_19829295_ChIP-Seq_ESCs_Human	0.66736239
80	NANOG_19829295_ChIP-Seq_ESCs_Human	0.66736239
81	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.64979451
82	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.64181288
83	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.60430441
84	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.60191913
85	OCT4_20526341_ChIP-Seq_ESCs_Human	0.60058802
86	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.59413497
87	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.59289138
88	SMAD4_21741376_ChIP-Seq_HESCs_Human	0.59165425
89	MYC_19829295_ChIP-Seq_ESCs_Human	0.58856291
90	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.56823934
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.56683129
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.56683129
93	AR_25329375_ChIP-Seq_VCAP_Human	0.56366511
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.56357318
95	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.54049367
96	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.54049367
97	TAF2_19829295_ChIP-Seq_ESCs_Human	0.52134897
98	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.52054259
99	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.51522025
100	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.50974326

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.45241083
2	MP0005360_urolithiasis	6.59784033
3	MP0005085_abnormal_gallbladder_physiolo	4.87094790
4	MP0005365_abnormal_bile_salt	4.77024085
5	MP0003195_calcinosis	4.66965567
6	MP0003718_maternal_effect	4.08411168
7	MP0001666_abnormal_nutrient_absorption	3.89575295
8	MP0008875_abnormal_xenobiotic_pharmacok	3.61547110
9	MP0009840_abnormal_foam_cell	3.39826639
10	MP0003252_abnormal_bile_duct	3.36763375
11	MP0010329_abnormal_lipoprotein_level	3.13048068
12	MP0002138_abnormal_hepatobiliary_system	2.86607937
13	MP0003868_abnormal_feces_composition	2.66814539
14	MP0006292_abnormal_olfactory_placode	2.45086325
15	MP0000566_synostosis	2.38070206
16	MP0003122_maternal_imprinting	2.26092162
17	MP0005395_other_phenotype	1.97812044
18	MP0003879_abnormal_hair_cell	1.80943464
19	MP0003890_abnormal_embryonic-extraembry	1.80700828
20	MP0005332_abnormal_amino_acid	1.76342048
21	MP0010368_abnormal_lymphatic_system	1.73670643
22	MP0002118_abnormal_lipid_homeostasis	1.54689208
23	MP0005408_hypopigmentation	1.49434348
24	MP0003183_abnormal_peptide_metabolism	1.49139713
25	MP0008789_abnormal_olfactory_epithelium	1.47525131
26	MP0004019_abnormal_vitamin_homeostasis	1.42888575
27	MP0005499_abnormal_olfactory_system	1.40961281
28	MP0005394_taste/olfaction_phenotype	1.40961281
29	MP0000609_abnormal_liver_physiology	1.32310950
30	MP0003699_abnormal_female_reproductive	1.27487823
31	MP0003950_abnormal_plasma_membrane	1.24846006
32	MP0009697_abnormal_copulation	1.20970922
33	MP0002876_abnormal_thyroid_physiology	1.16398026
34	MP0002132_abnormal_respiratory_system	1.15060171
35	MP0005410_abnormal_fertilization	1.14935413
36	MP0002089_abnormal_postnatal_growth/wei	1.10296725
37	MP0001764_abnormal_homeostasis	1.07684431
38	MP0003121_genomic_imprinting	1.06470120
39	MP0003191_abnormal_cellular_cholesterol	1.04092036
40	MP0005319_abnormal_enzyme/_coenzyme	1.02084797
41	MP0005646_abnormal_pituitary_gland	0.99848335
42	MP0010030_abnormal_orbit_morphology	0.97183412
43	MP0001929_abnormal_gametogenesis	0.94246652
44	MP0002160_abnormal_reproductive_system	0.92899583
45	MP0008877_abnormal_DNA_methylation	0.91482298
46	MP0010234_abnormal_vibrissa_follicle	0.90742376
47	MP0002234_abnormal_pharynx_morphology	0.88306748
48	MP0001293_anophthalmia	0.86581265
49	MP0005451_abnormal_body_composition	0.84511460
50	MP0001915_intracranial_hemorrhage	0.84301396
51	MP0002161_abnormal_fertility/fecundity	0.82912024
52	MP0005647_abnormal_sex_gland	0.78865161
53	MP0005058_abnormal_lysosome_morphology	0.78750144
54	MP0005409_darkened_coat_color	0.74990904
55	MP0005636_abnormal_mineral_homeostasis	0.73240296
56	MP0000653_abnormal_sex_gland	0.73075337
57	MP0000598_abnormal_liver_morphology	0.71265146
58	MP0003123_paternal_imprinting	0.71114288
59	MP0009780_abnormal_chondrocyte_physiolo	0.70096248
60	MP0009642_abnormal_blood_homeostasis	0.70039250
61	MP0003136_yellow_coat_color	0.69627604
62	MP0001324_abnormal_eye_pigmentation	0.69431642
63	MP0002210_abnormal_sex_determination	0.69054352
64	MP0003656_abnormal_erythrocyte_physiolo	0.68264092
65	MP0003806_abnormal_nucleotide_metabolis	0.67436366
66	MP0002233_abnormal_nose_morphology	0.67164113
67	MP0009643_abnormal_urine_homeostasis	0.63668989
68	MP0005551_abnormal_eye_electrophysiolog	0.62458025
69	MP0003693_abnormal_embryo_hatching	0.61977126
70	MP0004043_abnormal_pH_regulation	0.58769244
71	MP0004142_abnormal_muscle_tone	0.54480662
72	MP0000639_abnormal_adrenal_gland	0.54157416
73	MP0001730_embryonic_growth_arrest	0.52868211
74	MP0001756_abnormal_urination	0.51492192
75	MP0001119_abnormal_female_reproductive	0.50954708
76	MP0003698_abnormal_male_reproductive	0.50942095
77	MP0002078_abnormal_glucose_homeostasis	0.49992481
78	MP0001986_abnormal_taste_sensitivity	0.49744025
79	MP0003953_abnormal_hormone_level	0.49519828
80	MP0001145_abnormal_male_reproductive	0.49367778
81	MP0003941_abnormal_skin_development	0.49314989
82	MP0000762_abnormal_tongue_morphology	0.48669720
83	MP0005376_homeostasis/metabolism_phenot	0.47191156
84	MP0003119_abnormal_digestive_system	0.45614201
85	MP0005584_abnormal_enzyme/coenzyme_acti	0.45421937
86	MP0005389_reproductive_system_phenotype	0.43503302
87	MP0005084_abnormal_gallbladder_morpholo	0.43397300
88	MP0000678_abnormal_parathyroid_gland	0.43094220
89	MP0001984_abnormal_olfaction	0.42750645
90	MP0002971_abnormal_brown_adipose	0.42280489
91	MP0001661_extended_life_span	0.41240366
92	MP0005464_abnormal_platelet_physiology	0.40588327
93	MP0003567_abnormal_fetal_cardiomyocyte	0.39116681
94	MP0009115_abnormal_fat_cell	0.38661038
95	MP0002168_other_aberrant_phenotype	0.38284271
96	MP0002282_abnormal_trachea_morphology	0.37636467
97	MP0005334_abnormal_fat_pad	0.37227826
98	MP0005220_abnormal_exocrine_pancreas	0.36745581
99	MP0008469_abnormal_protein_level	0.36675956
100	MP0001944_abnormal_pancreas_morphology	0.35879342

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	9.81483894
2	Prolonged partial thromboplastin time (HP:0003645)	7.99724551
3	Hypobetalipoproteinemia (HP:0003563)	7.05181076
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.86718962
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	6.83372902
6	Complement deficiency (HP:0004431)	6.23320688
7	Joint hemorrhage (HP:0005261)	5.88147908
8	Abnormality of the common coagulation pathway (HP:0010990)	4.85518765
9	Abnormality of complement system (HP:0005339)	4.65344893
10	Hypolipoproteinemia (HP:0010981)	4.49013739
11	Intrahepatic cholestasis (HP:0001406)	4.48452121
12	Xanthomatosis (HP:0000991)	4.42957072
13	Spontaneous abortion (HP:0005268)	4.34927946
14	Hypophosphatemic rickets (HP:0004912)	4.32144677
15	Osteomalacia (HP:0002749)	4.21124132
16	Conjugated hyperbilirubinemia (HP:0002908)	4.15098311
17	Systemic lupus erythematosus (HP:0002725)	4.06055844
18	Glomerulonephritis (HP:0000099)	4.05191474
19	Hypercholesterolemia (HP:0003124)	3.80482261
20	Fat malabsorption (HP:0002630)	3.67373526
21	Hyperlipoproteinemia (HP:0010980)	3.62795706
22	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.55757294
23	Generalized aminoaciduria (HP:0002909)	3.36670298
24	Hyperglycinemia (HP:0002154)	3.34974963
25	Hemorrhage of the eye (HP:0011885)	3.33989645
26	Vascular calcification (HP:0004934)	3.31143310
27	Rickets (HP:0002748)	3.25093471
28	Abnormality of glutamine family amino acid metabolism (HP:0010902)	3.19391093
29	Cholecystitis (HP:0001082)	3.12213408
30	Abnormal gallbladder physiology (HP:0012438)	3.12213408
31	Supernumerary spleens (HP:0009799)	3.05440254
32	Hypoalphalipoproteinemia (HP:0003233)	3.01785728
33	Epidermoid cyst (HP:0200040)	3.01329858
34	Menorrhagia (HP:0000132)	2.98283918
35	Abnormal tarsal ossification (HP:0008369)	2.90922884
36	Acanthocytosis (HP:0001927)	2.87783961
37	Cardiovascular calcification (HP:0011915)	2.83100654
38	Hypoglycemic coma (HP:0001325)	2.76176138
39	Steatorrhea (HP:0002570)	2.75261333
40	Proximal tubulopathy (HP:0000114)	2.73474445
41	Abnormality of carpal bone ossification (HP:0006257)	2.66332372
42	Mitral stenosis (HP:0001718)	2.60666598
43	Abnormality of serine family amino acid metabolism (HP:0010894)	2.57764268
44	Abnormality of glycine metabolism (HP:0010895)	2.57764268
45	Abnormality of pyrimidine metabolism (HP:0004353)	2.57423321
46	Abnormality of the intrinsic pathway (HP:0010989)	2.57206499
47	Gingival bleeding (HP:0000225)	2.55400324
48	Broad alveolar ridges (HP:0000187)	2.42128565
49	Impulsivity (HP:0100710)	2.41974701
50	Nephritis (HP:0000123)	2.38257464
51	Fair hair (HP:0002286)	2.36224775
52	Pigmentary retinal degeneration (HP:0001146)	2.31717754
53	Flat acetabular roof (HP:0003180)	2.31596194
54	Azoospermia (HP:0000027)	2.29493633
55	Malnutrition (HP:0004395)	2.27982570
56	Purpura (HP:0000979)	2.27070215
57	Facial hemangioma (HP:0000329)	2.25452586
58	Bifid scrotum (HP:0000048)	2.24628132
59	Glycosuria (HP:0003076)	2.21549403
60	Abnormality of urine glucose concentration (HP:0011016)	2.21549403
61	Papillary thyroid carcinoma (HP:0002895)	2.21303984
62	Hyperglycinuria (HP:0003108)	2.20314365
63	Metaphyseal irregularity (HP:0003025)	2.17435327
64	Thrombophlebitis (HP:0004418)	2.15324552
65	Abnormal urine phosphate concentration (HP:0012599)	2.14792086
66	Hyperammonemia (HP:0001987)	2.13276107
67	Recurrent gram-negative bacterial infections (HP:0005420)	2.12427297
68	Prenatal maternal abnormality (HP:0002686)	2.11113795
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.10047731
70	Premature ovarian failure (HP:0008209)	2.06931506
71	Delayed CNS myelination (HP:0002188)	2.06645961
72	Abnormality of methionine metabolism (HP:0010901)	2.04387881
73	Hepatocellular carcinoma (HP:0001402)	2.03970588
74	Myocardial infarction (HP:0001658)	2.01580147
75	Abnormal hand bone ossification (HP:0010660)	2.00666584
76	Enlarged kidneys (HP:0000105)	1.96465450
77	Megaloblastic anemia (HP:0001889)	1.93688975
78	Abnormality of sulfur amino acid metabolism (HP:0004339)	1.93123216
79	Hyperphosphaturia (HP:0003109)	1.92451852
80	Abnormality of vitamin metabolism (HP:0100508)	1.90081139
81	Poikilocytosis (HP:0004447)	1.88743457
82	Abnormality of proline metabolism (HP:0010907)	1.83574102
83	Hydroxyprolinuria (HP:0003080)	1.83574102
84	Lower limb hyperreflexia (HP:0002395)	1.83097756
85	Abnormal ossification of hand bones (HP:0005921)	1.81593066
86	Nausea (HP:0002018)	1.77733901
87	Abnormality of nucleobase metabolism (HP:0010932)	1.76606282
88	Elevated alkaline phosphatase (HP:0003155)	1.75138304
89	Potter facies (HP:0002009)	1.75054125
90	Facial shape deformation (HP:0011334)	1.75054125
91	Increased serum pyruvate (HP:0003542)	1.73199809
92	Striae distensae (HP:0001065)	1.72740056
93	Abnormal foot bone ossification (HP:0010675)	1.72039000
94	Retinal atrophy (HP:0001105)	1.70413408
95	Capillary hemangiomas (HP:0005306)	1.70161438
96	Male infertility (HP:0003251)	1.68100823
97	Abnormality of alkaline phosphatase activity (HP:0004379)	1.67130194
98	Abnormal enzyme/coenzyme activity (HP:0012379)	1.65935631
99	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.62868614
100	Hypophosphatemia (HP:0002148)	1.60193512

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.44010472
2	ARAF	4.44142363
3	MAP3K13	4.36887593
4	FGFR4	4.08135211
5	CDK12	3.26918105
6	FGFR3	2.67960007
7	STK24	2.44684061
8	WNK4	2.29072615
9	TAOK3	2.26103158
10	NEK6	2.17850914
11	KSR2	2.17607779
12	LATS1	2.00646068
13	ICK	1.98061349
14	TTK	1.92188380
15	MET	1.86472408
16	BRAF	1.76216270
17	CDK9	1.67752601
18	CDK7	1.66108981
19	NEK9	1.53511263
20	PIK3CA	1.52453434
21	ERN1	1.52309572
22	TYRO3	1.51565525
23	MOS	1.50586238
24	EIF2AK3	1.45332954
25	LATS2	1.38140551
26	RAF1	1.35322221
27	WNK1	1.35311857
28	AURKA	1.32178602
29	MELK	1.31432285
30	MAPKAPK3	1.27330477
31	PRKAA2	1.25287193
32	NEK2	1.17076196
33	NTRK3	1.14436183
34	MAPK11	1.11965969
35	BRSK2	1.07037271
36	FGFR2	1.04260861
37	RET	1.03802224
38	PDPK1	1.02799568
39	FGFR1	1.00287173
40	RIPK1	1.00048151
41	NTRK2	0.99641623
42	BRSK1	0.93275702
43	ZAK	0.91140111
44	PLK1	0.86363807
45	STK39	0.85505467
46	STK3	0.85368763
47	PRKCI	0.82264753
48	EPHA4	0.81292077
49	PDK1	0.79771473
50	NLK	0.78975374
51	CSNK1E	0.78001135
52	EEF2K	0.76674676
53	EIF2AK1	0.75660230
54	CDK8	0.72440853
55	PRKG1	0.71071040
56	ACVR1B	0.69781022
57	DYRK1B	0.66636644
58	CSNK1D	0.66450301
59	STK38L	0.64294298
60	MAP3K5	0.63117477
61	CDC7	0.63098115
62	AKT3	0.61480224
63	MAP3K1	0.59839276
64	PRKCZ	0.59526290
65	PTK2	0.59464396
66	PIK3CG	0.59223616
67	PRKACG	0.59118527
68	PKN2	0.56390459
69	TNIK	0.53514607
70	PLK3	0.52555263
71	TESK2	0.52370894
72	MAP3K8	0.49504851
73	PRKAA1	0.46599224
74	MTOR	0.46568952
75	CDK2	0.46563698
76	PDGFRA	0.45964650
77	ERBB2	0.44587720
78	MAP3K2	0.44239030
79	BCKDK	0.43612695
80	PRKACB	0.40434660
81	AURKB	0.38837941
82	RPS6KB1	0.38799865
83	PRKACA	0.37701807
84	NME1	0.37580815
85	TRIB3	0.37119652
86	CHEK1	0.36971911
87	CDK1	0.36411729
88	CSNK2A2	0.35659177
89	IGF1R	0.35650664
90	PIM1	0.35252225
91	TGFBR2	0.35116335
92	ATM	0.33537988
93	NUAK1	0.32669498
94	MAP3K3	0.31758281
95	AKT2	0.30850820
96	PBK	0.30488371
97	CSNK2A1	0.30260354
98	STK16	0.30253028
99	CSNK1G1	0.28740628
100	SGK1	0.27532117

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Complement and coagulation cascades_Homo sapiens_hsa04610	4.31843825
2	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.90808802
3	Caffeine metabolism_Homo sapiens_hsa00232	3.79774359
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.22672736
5	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.00679131
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.76306191
7	Retinol metabolism_Homo sapiens_hsa00830	2.67174965
8	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.57130573
9	Arginine biosynthesis_Homo sapiens_hsa00220	2.53466298
10	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.46581817
11	Chemical carcinogenesis_Homo sapiens_hsa05204	2.43901800
12	Fatty acid degradation_Homo sapiens_hsa00071	2.30762066
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.30288539
14	Phenylalanine metabolism_Homo sapiens_hsa00360	2.19385752
15	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.17643622
16	Histidine metabolism_Homo sapiens_hsa00340	2.12668943
17	Fat digestion and absorption_Homo sapiens_hsa04975	2.12444150
18	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.08915088
19	Butanoate metabolism_Homo sapiens_hsa00650	2.01265122
20	Bile secretion_Homo sapiens_hsa04976	2.00599892
21	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.93443106
22	Tyrosine metabolism_Homo sapiens_hsa00350	1.86163091
23	PPAR signaling pathway_Homo sapiens_hsa03320	1.80311359
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.78250951
25	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.64514671
26	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.58847638
27	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.57857534
28	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.51223766
29	Tryptophan metabolism_Homo sapiens_hsa00380	1.46908006
30	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44501584
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38662130
32	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.38454628
33	Fatty acid metabolism_Homo sapiens_hsa01212	1.34027143
34	Steroid biosynthesis_Homo sapiens_hsa00100	1.33637784
35	Arginine and proline metabolism_Homo sapiens_hsa00330	1.32266276
36	Peroxisome_Homo sapiens_hsa04146	1.29491904
37	ABC transporters_Homo sapiens_hsa02010	1.29412311
38	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.27387871
39	Propanoate metabolism_Homo sapiens_hsa00640	1.24169693
40	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.20170929
41	Linoleic acid metabolism_Homo sapiens_hsa00591	1.19782678
42	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.12927191
43	Pyruvate metabolism_Homo sapiens_hsa00620	1.10041308
44	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.06042150
45	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.05521312
46	Fatty acid elongation_Homo sapiens_hsa00062	1.05142454
47	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.00552087
48	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.97759723
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.88953839
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.87108896
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.87061214
52	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.83157968
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.83057335
54	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.78478683
55	Basal transcription factors_Homo sapiens_hsa03022	0.76627991
56	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73771085
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70005668
58	Carbon metabolism_Homo sapiens_hsa01200	0.68282687
59	Folate biosynthesis_Homo sapiens_hsa00790	0.64817574
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.63387392
61	Prion diseases_Homo sapiens_hsa05020	0.61721140
62	One carbon pool by folate_Homo sapiens_hsa00670	0.57227089
63	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.56743567
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.55129367
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.54629257
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.52044054
67	Renin-angiotensin system_Homo sapiens_hsa04614	0.51888267
68	Lysine degradation_Homo sapiens_hsa00310	0.50872226
69	Metabolic pathways_Homo sapiens_hsa01100	0.50358637
70	Sulfur metabolism_Homo sapiens_hsa00920	0.46651405
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.44241176
72	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.37202162
73	Glutathione metabolism_Homo sapiens_hsa00480	0.37039611
74	Other glycan degradation_Homo sapiens_hsa00511	0.36158257
75	Cell cycle_Homo sapiens_hsa04110	0.35212917
76	Mineral absorption_Homo sapiens_hsa04978	0.33718957
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.31929155
78	Oocyte meiosis_Homo sapiens_hsa04114	0.26495937
79	Circadian rhythm_Homo sapiens_hsa04710	0.26263483
80	Sulfur relay system_Homo sapiens_hsa04122	0.23747600
81	Insulin resistance_Homo sapiens_hsa04931	0.23644323
82	Galactose metabolism_Homo sapiens_hsa00052	0.22885321
83	Sphingolipid metabolism_Homo sapiens_hsa00600	0.20208682
84	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.18074690
85	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17595868
86	Base excision repair_Homo sapiens_hsa03410	0.17107538
87	Mismatch repair_Homo sapiens_hsa03430	0.15268757
88	Pentose phosphate pathway_Homo sapiens_hsa00030	0.08621876
89	Pertussis_Homo sapiens_hsa05133	0.08142140
90	RNA degradation_Homo sapiens_hsa03018	0.07951994
91	Glucagon signaling pathway_Homo sapiens_hsa04922	0.07758867
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.05934301
93	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.04254932
94	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.03892957
95	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.01613234
96	Protein digestion and absorption_Homo sapiens_hsa04974	0.00730622
97	Ether lipid metabolism_Homo sapiens_hsa00565	0.00706319
98	Nucleotide excision repair_Homo sapiens_hsa03420	0.00227547
99	Selenocompound metabolism_Homo sapiens_hsa00450	-0.0062368
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	-0.0029152

ABCC6P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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