ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.52579874
2	L-phenylalanine catabolic process (GO:0006559)	7.52579874
3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.31673757
4	L-phenylalanine metabolic process (GO:0006558)	7.31673757
5	regulation of cholesterol esterification (GO:0010872)	5.19035822
6	regulation of fibrinolysis (GO:0051917)	5.13066349
7	negative regulation of fibrinolysis (GO:0051918)	4.98191548
8	regulation of protein activation cascade (GO:2000257)	4.86519695
9	protein carboxylation (GO:0018214)	4.68923218
10	peptidyl-glutamic acid carboxylation (GO:0017187)	4.68923218
11	very-low-density lipoprotein particle assembly (GO:0034379)	4.64838222
12	glyoxylate metabolic process (GO:0046487)	4.55394227
13	regulation of complement activation (GO:0030449)	4.53568847
14	aromatic amino acid family catabolic process (GO:0009074)	4.39384021
15	plasma lipoprotein particle assembly (GO:0034377)	4.35573546
16	high-density lipoprotein particle remodeling (GO:0034375)	4.34575755
17	negative regulation of protein activation cascade (GO:2000258)	4.15175647
18	growth hormone secretion (GO:0030252)	4.08001513
19	reverse cholesterol transport (GO:0043691)	4.06791068
20	protein-lipid complex remodeling (GO:0034368)	4.05842845
21	macromolecular complex remodeling (GO:0034367)	4.05842845
22	plasma lipoprotein particle remodeling (GO:0034369)	4.05842845
23	phospholipid efflux (GO:0033700)	4.03705386
24	cholesterol efflux (GO:0033344)	3.99128304
25	adult feeding behavior (GO:0008343)	3.88332178
26	negative regulation of cholesterol transport (GO:0032375)	3.85910403
27	negative regulation of sterol transport (GO:0032372)	3.85910403
28	phenylpropanoid metabolic process (GO:0009698)	3.85803760
29	blood coagulation, intrinsic pathway (GO:0007597)	3.85422510
30	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	3.82838478
31	amino-acid betaine metabolic process (GO:0006577)	3.79159672
32	sphingosine metabolic process (GO:0006670)	3.67189271
33	fibrinolysis (GO:0042730)	3.67093606
34	serine family amino acid catabolic process (GO:0009071)	3.63404792
35	triglyceride homeostasis (GO:0070328)	3.61255446
36	acylglycerol homeostasis (GO:0055090)	3.61255446
37	protein-lipid complex assembly (GO:0065005)	3.60995616
38	negative regulation of complement activation (GO:0045916)	3.59619259
39	plasma lipoprotein particle clearance (GO:0034381)	3.50953709
40	epoxygenase P450 pathway (GO:0019373)	3.49226747
41	positive regulation of growth hormone secretion (GO:0060124)	3.45065780
42	aldehyde catabolic process (GO:0046185)	3.44670852
43	low-density lipoprotein particle remodeling (GO:0034374)	3.43804828
44	intestinal cholesterol absorption (GO:0030299)	3.42032641
45	xenobiotic catabolic process (GO:0042178)	3.40518328
46	diol metabolic process (GO:0034311)	3.34910857
47	plasma lipoprotein particle organization (GO:0071827)	3.34887425
48	cellular glucuronidation (GO:0052695)	3.34756091
49	endocrine hormone secretion (GO:0060986)	3.33026569
50	sphingoid metabolic process (GO:0046519)	3.32625788
51	drug catabolic process (GO:0042737)	3.31485915
52	cellular ketone body metabolic process (GO:0046950)	3.27979877
53	regulation of plasminogen activation (GO:0010755)	3.27740518
54	regulation of glucocorticoid secretion (GO:2000849)	3.26316834
55	uronic acid metabolic process (GO:0006063)	3.25632938
56	glucuronate metabolic process (GO:0019585)	3.25632938
57	positive regulation of triglyceride lipase activity (GO:0061365)	3.23841403
58	positive regulation of lipoprotein lipase activity (GO:0051006)	3.23841403
59	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.22437447
60	heme transport (GO:0015886)	3.19992073
61	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.17546596
62	drug metabolic process (GO:0017144)	3.17365127
63	polyketide metabolic process (GO:0030638)	3.13806238
64	doxorubicin metabolic process (GO:0044598)	3.13806238
65	daunorubicin metabolic process (GO:0044597)	3.13806238
66	bile acid metabolic process (GO:0008206)	3.13492740
67	aminoglycoside antibiotic metabolic process (GO:0030647)	3.09186013
68	cholesterol homeostasis (GO:0042632)	3.08644184
69	positive regulation of heterotypic cell-cell adhesion (GO:0034116)	3.08065030
70	negative regulation of interleukin-1 beta production (GO:0032691)	3.07617197
71	regulation of triglyceride catabolic process (GO:0010896)	3.07539751
72	response to mercury ion (GO:0046689)	3.04654573
73	complement activation, alternative pathway (GO:0006957)	3.03005962
74	negative regulation of lipase activity (GO:0060192)	3.02154985
75	regulation of bile acid biosynthetic process (GO:0070857)	3.02136618
76	negative regulation of blood coagulation (GO:0030195)	3.02127921
77	negative regulation of hemostasis (GO:1900047)	3.02127921
78	sterol homeostasis (GO:0055092)	3.01557208
79	glycine metabolic process (GO:0006544)	3.01205987
80	alpha-amino acid catabolic process (GO:1901606)	3.01034095
81	protein-lipid complex subunit organization (GO:0071825)	3.00310743
82	bile acid biosynthetic process (GO:0006699)	3.00032292
83	proline metabolic process (GO:0006560)	2.98060370
84	flavonoid metabolic process (GO:0009812)	2.94252622
85	aromatic amino acid family metabolic process (GO:0009072)	2.91866041
86	tyrosine metabolic process (GO:0006570)	2.90626929
87	negative regulation of coagulation (GO:0050819)	2.87918712
88	vitamin transmembrane transport (GO:0035461)	2.85247431
89	ketone body metabolic process (GO:1902224)	2.82456899
90	regulation of protein glycosylation (GO:0060049)	2.82052114
91	negative regulation of humoral immune response (GO:0002921)	2.81368675
92	regulation of apoptotic cell clearance (GO:2000425)	2.79177862
93	response to nitrosative stress (GO:0051409)	2.77288996
94	cellular amino acid catabolic process (GO:0009063)	2.73817060
95	primary alcohol catabolic process (GO:0034310)	2.73304822
96	L-ascorbic acid metabolic process (GO:0019852)	2.73113783
97	negative regulation of wound healing (GO:0061045)	2.71875346
98	serine family amino acid metabolic process (GO:0009069)	2.71311519
99	nodal signaling pathway (GO:0038092)	2.71308544
100	phospholipid homeostasis (GO:0055091)	2.70255959

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	6.66729412
2	EGR1_23403033_ChIP-Seq_LIVER_Mouse	4.37923189
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.23463985
4	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.84019793
5	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	3.17191689
6	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.16854842
7	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.07046646
8	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.93579561
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.24017445
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.18745443
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.18215255
12	HNF4A_19822575_ChIP-Seq_HepG2_Human	2.15124193
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.09983856
14	FOXA2_19822575_ChIP-Seq_HepG2_Human	2.04706677
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.98153290
16	GATA4_25053715_ChIP-Seq_YYC3_Human	1.93001493
17	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.91363843
18	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.83216468
19	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.78027258
20	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.69894218
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57990224
22	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.57314097
23	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.54339911
24	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.53583002
25	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.46347088
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.43552549
27	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	1.41073926
28	VDR_22108803_ChIP-Seq_LS180_Human	1.37597790
29	HTT_18923047_ChIP-ChIP_STHdh_Human	1.37335947
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.33771481
31	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.28489791
32	AR_21909140_ChIP-Seq_LNCAP_Human	1.27551047
33	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.23568921
34	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23099573
35	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23099573
36	ZNF274_21170338_ChIP-Seq_K562_Hela	1.22750897
37	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21556195
38	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.20917054
39	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.18042609
40	TCF4_22108803_ChIP-Seq_LS180_Human	1.17939380
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.15429216
42	SOX2_20726797_ChIP-Seq_SW620_Human	1.13939005
43	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13918666
44	P300_19829295_ChIP-Seq_ESCs_Human	1.12623490
45	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.12439104
46	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10163162
47	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10163162
48	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.08611917
49	AR_20517297_ChIP-Seq_VCAP_Human	1.08440082
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.08206464
51	SALL4_18804426_ChIP-ChIP_XEN_Mouse	1.07858089
52	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.07483265
53	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.07293601
54	HOXB7_26014856_ChIP-Seq_BT474_Human	1.07118200
55	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.06224848
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05827094
57	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.05767254
58	GATA6_25053715_ChIP-Seq_YYC3_Human	1.05620281
59	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04978319
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.04325225
61	CDX2_22108803_ChIP-Seq_LS180_Human	1.04289978
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.04063822
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02885799
64	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.02866538
65	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.02193405
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.00478877
67	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.99558074
68	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.99511894
69	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	0.98631364
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97818927
71	TAF15_26573619_Chip-Seq_HEK293_Human	0.96569428
72	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.96432364
73	* OCT4_20526341_ChIP-Seq_ESCs_Human	0.94094946
74	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.92805029
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.92151413
76	BCAT_22108803_ChIP-Seq_LS180_Human	0.91754976
77	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.91460929
78	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.91294784
79	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	0.90500899
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.90376298
81	EOMES_21245162_ChIP-Seq_HESCs_Human	0.90172851
82	FUS_26573619_Chip-Seq_HEK293_Human	0.89938454
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.89783032
84	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.89170837
85	NCOR_22424771_ChIP-Seq_293T_Human	0.88902246
86	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.88899956
87	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.88643959
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.87146383
89	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.87124337
90	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87007468
91	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.86267571
92	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.86205207
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.86103199
94	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.85921612
95	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.85811097
96	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.84394984
97	CJUN_26792858_Chip-Seq_BT549_Human	0.84235837
98	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.83531629
99	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.83280647
100	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.82973733

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	5.93551025
2	MP0002139_abnormal_hepatobiliary_system	5.43038600
3	MP0005365_abnormal_bile_salt	4.76481058
4	MP0005085_abnormal_gallbladder_physiolo	4.20891456
5	MP0002837_dystrophic_cardiac_calcinosis	3.53186903
6	MP0005360_urolithiasis	3.18346137
7	MP0010329_abnormal_lipoprotein_level	3.07262970
8	MP0002138_abnormal_hepatobiliary_system	3.06833482
9	MP0008875_abnormal_xenobiotic_pharmacok	3.06001969
10	MP0002876_abnormal_thyroid_physiology	2.97642664
11	MP0003252_abnormal_bile_duct	2.92643945
12	MP0003136_yellow_coat_color	2.85489859
13	MP0001666_abnormal_nutrient_absorption	2.44808685
14	MP0003122_maternal_imprinting	2.39445783
15	MP0003890_abnormal_embryonic-extraembry	2.29187318
16	MP0002938_white_spotting	2.10923135
17	MP0005332_abnormal_amino_acid	2.06596472
18	MP0009840_abnormal_foam_cell	2.03329120
19	MP0002653_abnormal_ependyma_morphology	1.95823463
20	MP0009697_abnormal_copulation	1.91928901
21	MP0000566_synostosis	1.90018729
22	MP0004019_abnormal_vitamin_homeostasis	1.87699315
23	MP0004043_abnormal_pH_regulation	1.87687747
24	MP0003868_abnormal_feces_composition	1.85362215
25	MP0005670_abnormal_white_adipose	1.84558693
26	MP0005408_hypopigmentation	1.80914028
27	MP0003011_delayed_dark_adaptation	1.80323610
28	MP0002168_other_aberrant_phenotype	1.55892697
29	MP0002118_abnormal_lipid_homeostasis	1.47004660
30	MP0005220_abnormal_exocrine_pancreas	1.40409832
31	MP0003879_abnormal_hair_cell	1.39922592
32	MP0001764_abnormal_homeostasis	1.39381190
33	MP0002909_abnormal_adrenal_gland	1.32895430
34	MP0005636_abnormal_mineral_homeostasis	1.31877429
35	MP0001756_abnormal_urination	1.29254213
36	MP0003186_abnormal_redox_activity	1.29195896
37	MP0005395_other_phenotype	1.27925502
38	MP0003123_paternal_imprinting	1.22252131
39	MP0010368_abnormal_lymphatic_system	1.22141928
40	MP0006072_abnormal_retinal_apoptosis	1.18888911
41	MP0001984_abnormal_olfaction	1.18871345
42	MP0004133_heterotaxia	1.15988788
43	MP0000609_abnormal_liver_physiology	1.13774356
44	MP0006054_spinal_hemorrhage	1.13016737
45	MP0009643_abnormal_urine_homeostasis	1.11639774
46	MP0003045_fibrosis	1.09406601
47	MP0002160_abnormal_reproductive_system	1.07537306
48	MP0005551_abnormal_eye_electrophysiolog	1.05585143
49	MP0001944_abnormal_pancreas_morphology	1.04895503
50	MP0005266_abnormal_metabolism	1.04440121
51	MP0006036_abnormal_mitochondrial_physio	1.01883042
52	MP0005379_endocrine/exocrine_gland_phen	0.97189507
53	MP0002078_abnormal_glucose_homeostasis	0.96912194
54	MP0005319_abnormal_enzyme/_coenzyme	0.95596534
55	MP0002132_abnormal_respiratory_system	0.95052197
56	MP0005171_absent_coat_pigmentation	0.93090443
57	MP0010386_abnormal_urinary_bladder	0.90889282
58	MP0001661_extended_life_span	0.90807867
59	MP0004272_abnormal_basement_membrane	0.90649853
60	MP0005187_abnormal_penis_morphology	0.90043880
61	MP0002254_reproductive_system_inflammat	0.88842886
62	MP0003953_abnormal_hormone_level	0.87577694
63	MP0005376_homeostasis/metabolism_phenot	0.86556800
64	MP0003183_abnormal_peptide_metabolism	0.80619701
65	MP0009780_abnormal_chondrocyte_physiolo	0.80272463
66	MP0005248_abnormal_Harderian_gland	0.77442553
67	MP0003121_genomic_imprinting	0.77381251
68	MP0001324_abnormal_eye_pigmentation	0.74788237
69	MP0009642_abnormal_blood_homeostasis	0.74160186
70	MP0005448_abnormal_energy_balance	0.73832226
71	MP0002971_abnormal_brown_adipose	0.73518395
72	MP0001346_abnormal_lacrimal_gland	0.72888475
73	MP0003718_maternal_effect	0.71587443
74	MP0003646_muscle_fatigue	0.70313165
75	MP0000639_abnormal_adrenal_gland	0.67581733
76	MP0005058_abnormal_lysosome_morphology	0.65650136
77	MP0005646_abnormal_pituitary_gland	0.64943696
78	MP0003878_abnormal_ear_physiology	0.63819148
79	MP0005377_hearing/vestibular/ear_phenot	0.63819148
80	MP0000598_abnormal_liver_morphology	0.63680083
81	MP0003943_abnormal_hepatobiliary_system	0.62923189
82	MP0005084_abnormal_gallbladder_morpholo	0.61835808
83	MP0003941_abnormal_skin_development	0.61581222
84	MP0002693_abnormal_pancreas_physiology	0.60858556
85	MP0000647_abnormal_sebaceous_gland	0.60446794
86	MP0001915_intracranial_hemorrhage	0.59906007
87	MP0005389_reproductive_system_phenotype	0.58651716
88	MP0002928_abnormal_bile_duct	0.58217878
89	MP0003806_abnormal_nucleotide_metabolis	0.56396123
90	MP0005410_abnormal_fertilization	0.56239778
91	MP0010352_gastrointestinal_tract_polyps	0.55921277
92	MP0005584_abnormal_enzyme/coenzyme_acti	0.55148141
93	MP0005253_abnormal_eye_physiology	0.53208251
94	MP0005330_cardiomyopathy	0.52764341
95	MP0003950_abnormal_plasma_membrane	0.51064595
96	MP0003638_abnormal_response/metabolism_	0.48531785
97	MP0005452_abnormal_adipose_tissue	0.48504705
98	MP0000653_abnormal_sex_gland	0.47381297
99	MP0006035_abnormal_mitochondrial_morpho	0.46382679
100	MP0009115_abnormal_fat_cell	0.44638429

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.44489552
2	Deep venous thrombosis (HP:0002625)	6.55667472
3	Hypobetalipoproteinemia (HP:0003563)	5.89182772
4	Prolonged partial thromboplastin time (HP:0003645)	5.77793489
5	Abnormality of monocarboxylic acid metabolism (HP:0010996)	4.79461653
6	Hypolipoproteinemia (HP:0010981)	4.19036512
7	Xanthomatosis (HP:0000991)	4.01889542
8	Acanthocytosis (HP:0001927)	4.01656606
9	Fat malabsorption (HP:0002630)	3.69350815
10	Joint hemorrhage (HP:0005261)	3.68761907
11	Intrahepatic cholestasis (HP:0001406)	3.47915050
12	Abnormality of the common coagulation pathway (HP:0010990)	3.41422912
13	Steatorrhea (HP:0002570)	3.41232332
14	Complement deficiency (HP:0004431)	3.37029203
15	Hyperglycinemia (HP:0002154)	3.33058554
16	Glomerulonephritis (HP:0000099)	3.22079201
17	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	3.09227832
18	Spontaneous abortion (HP:0005268)	3.08737557
19	Vascular calcification (HP:0004934)	3.06799590
20	Hypoalphalipoproteinemia (HP:0003233)	3.04828000
21	Amelogenesis imperfecta (HP:0000705)	2.94889498
22	Epidermoid cyst (HP:0200040)	2.93611724
23	Pancreatic islet-cell hyperplasia (HP:0004510)	2.91990846
24	Glycosuria (HP:0003076)	2.78910104
25	Abnormality of urine glucose concentration (HP:0011016)	2.78910104
26	Congenital malformation of the right heart (HP:0011723)	2.71284166
27	Double outlet right ventricle (HP:0001719)	2.71284166
28	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.67494727
29	Pigmentary retinal degeneration (HP:0001146)	2.63429743
30	Enlarged kidneys (HP:0000105)	2.55458090
31	Cardiovascular calcification (HP:0011915)	2.54810863
32	Hypomagnesemia (HP:0002917)	2.53512810
33	Facial shape deformation (HP:0011334)	2.52476431
34	Potter facies (HP:0002009)	2.52476431
35	Reduced antithrombin III activity (HP:0001976)	2.51571698
36	Abnormality of glycine metabolism (HP:0010895)	2.50427547
37	Abnormality of serine family amino acid metabolism (HP:0010894)	2.50427547
38	Increased circulating renin level (HP:0000848)	2.43528798
39	Generalized aminoaciduria (HP:0002909)	2.41267524
40	Hypoglycemic coma (HP:0001325)	2.40385648
41	Type I transferrin isoform profile (HP:0003642)	2.40140772
42	Pancreatic cysts (HP:0001737)	2.37859214
43	Gout (HP:0001997)	2.36914830
44	Increased serum pyruvate (HP:0003542)	2.36711740
45	Retinal atrophy (HP:0001105)	2.35867729
46	Abnormal respiratory motile cilium physiology (HP:0012261)	2.33136141
47	Rhinitis (HP:0012384)	2.30655185
48	Hyperphosphaturia (HP:0003109)	2.27483004
49	Abnormality of complement system (HP:0005339)	2.25625868
50	Abnormality of glycolysis (HP:0004366)	2.25393831
51	Hyperactive renin-angiotensin system (HP:0000841)	2.25031354
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.24158536
53	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24158536
54	Abnormality of pyrimidine metabolism (HP:0004353)	2.22427610
55	Systemic lupus erythematosus (HP:0002725)	2.21651046
56	Proximal tubulopathy (HP:0000114)	2.21041429
57	Parakeratosis (HP:0001036)	2.20115858
58	Arthropathy (HP:0003040)	2.20092389
59	Hypercholesterolemia (HP:0003124)	2.19800314
60	Abnormal ciliary motility (HP:0012262)	2.19129788
61	Abnormality of magnesium homeostasis (HP:0004921)	2.18931984
62	Hyperglycinuria (HP:0003108)	2.15542202
63	Hyperlipoproteinemia (HP:0010980)	2.14459112
64	Broad alveolar ridges (HP:0000187)	2.13822129
65	Hyperammonemia (HP:0001987)	2.13158492
66	Chronic hepatic failure (HP:0100626)	2.10300340
67	Abnormality of vitamin metabolism (HP:0100508)	2.09907107
68	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.08243098
69	Delayed CNS myelination (HP:0002188)	2.08167794
70	Conjugated hyperbilirubinemia (HP:0002908)	2.00924256
71	Abnormality of the intrinsic pathway (HP:0010989)	2.00296398
72	Abnormality of serum amino acid levels (HP:0003112)	1.99565200
73	Abnormal protein glycosylation (HP:0012346)	1.99502919
74	Abnormal glycosylation (HP:0012345)	1.99502919
75	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99502919
76	Abnormal protein N-linked glycosylation (HP:0012347)	1.99502919
77	Hypothermia (HP:0002045)	1.98402890
78	Abnormal tarsal ossification (HP:0008369)	1.97998516
79	Acute encephalopathy (HP:0006846)	1.93773445
80	True hermaphroditism (HP:0010459)	1.90237227
81	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.89572904
82	Opisthotonus (HP:0002179)	1.87740820
83	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.86504182
84	Absent/shortened dynein arms (HP:0200106)	1.86504182
85	Abnormality of methionine metabolism (HP:0010901)	1.85718402
86	Beaking of vertebral bodies (HP:0004568)	1.85492711
87	Metabolic acidosis (HP:0001942)	1.84910977
88	Abnormality of nucleobase metabolism (HP:0010932)	1.84843369
89	Abnormality of fatty-acid metabolism (HP:0004359)	1.84628119
90	Menorrhagia (HP:0000132)	1.81098691
91	Abnormal urine output (HP:0012590)	1.80622272
92	Vacuolated lymphocytes (HP:0001922)	1.80368866
93	Hypophosphatemic rickets (HP:0004912)	1.80190519
94	Renal salt wasting (HP:0000127)	1.78381727
95	Hepatocellular carcinoma (HP:0001402)	1.78378449
96	Rickets (HP:0002748)	1.77167246
97	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.76584081
98	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.75904805
99	Hypotension (HP:0002615)	1.75591696
100	Pancreatic fibrosis (HP:0100732)	1.75198484

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LATS1	6.02055620
2	STK38L	5.34465409
3	LATS2	3.74581632
4	WNK3	3.02547080
5	NLK	2.64307588
6	BUB1	2.63843240
7	NEK1	2.53004009
8	EPHA3	2.37698972
9	FGFR4	2.25741564
10	FRK	2.01277974
11	FER	1.90194686
12	STK3	1.88834107
13	OXSR1	1.78971496
14	EPHA2	1.78415695
15	MAP3K4	1.75263266
16	PBK	1.74576173
17	MST4	1.66793647
18	ACVR1B	1.64395474
19	STK38	1.63904300
20	ZAK	1.62008216
21	STK24	1.61054180
22	WNK4	1.57603227
23	PRKD3	1.51838094
24	MAP3K12	1.49653612
25	VRK2	1.47852202
26	BRSK2	1.42906799
27	MAP3K9	1.38831662
28	MAP3K2	1.33457197
29	TTK	1.29389236
30	CDK19	1.22517144
31	GRK1	1.19324178
32	EIF2AK3	1.19179591
33	BMPR1B	1.15051176
34	STK39	1.07142808
35	MUSK	1.05280844
36	WEE1	1.04615610
37	NEK2	1.02353347
38	NME1	1.00977737
39	EIF2AK1	1.00939371
40	CSNK1A1L	1.00298590
41	PRKAA2	0.99572212
42	FGFR3	0.99017081
43	FLT3	0.93676340
44	CASK	0.90139733
45	FGFR1	0.88071535
46	MYLK	0.87007121
47	BCKDK	0.86696501
48	PDK2	0.86428969
49	IRAK1	0.85925763
50	PKN2	0.82240135
51	PLK2	0.77613028
52	PAK4	0.76839308
53	MAPKAPK3	0.76756810
54	MELK	0.75941131
55	PRKCE	0.69586642
56	PLK3	0.69379151
57	ADRBK2	0.68783434
58	PLK1	0.68601803
59	CSNK1G1	0.67943047
60	PRKCG	0.64911436
61	STK4	0.64726107
62	PHKG2	0.62381616
63	PHKG1	0.62381616
64	INSRR	0.61830405
65	MKNK2	0.60189476
66	CAMK2D	0.58527635
67	CCNB1	0.55176469
68	PIK3CG	0.53556526
69	IRAK3	0.52211470
70	LIMK1	0.50059018
71	TGFBR2	0.49787787
72	BRSK1	0.46967692
73	MST1R	0.45938986
74	DAPK1	0.45792730
75	CSNK1G3	0.44802129
76	PIK3CA	0.43571555
77	PDPK1	0.42424406
78	MAPK15	0.41941219
79	ABL2	0.40605278
80	PTK2	0.40325141
81	CSNK1G2	0.39377195
82	AKT2	0.38445975
83	MKNK1	0.37827016
84	FGFR2	0.37658132
85	PRKACB	0.35913111
86	MAP2K2	0.34974364
87	MET	0.33628173
88	NEK9	0.32575718
89	ERBB3	0.32496275
90	CSNK1A1	0.32172620
91	SRPK1	0.31732252
92	AURKB	0.31250914
93	ERBB2	0.28287509
94	MAPK11	0.27691624
95	PAK3	0.27262806
96	CSNK2A1	0.26946299
97	DYRK2	0.25735326
98	MAP2K7	0.25561635
99	GRK7	0.24686387
100	PRKACA	0.22421128

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.55261584
2	Complement and coagulation cascades_Homo sapiens_hsa04610	2.86962235
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.82006616
4	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.68056483
5	Phenylalanine metabolism_Homo sapiens_hsa00360	2.55208264
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.49346953
7	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.43924758
8	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.28880714
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22724576
10	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.18636461
11	Butanoate metabolism_Homo sapiens_hsa00650	2.14827081
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.13533349
13	Fatty acid degradation_Homo sapiens_hsa00071	2.04642163
14	Histidine metabolism_Homo sapiens_hsa00340	2.02157039
15	Chemical carcinogenesis_Homo sapiens_hsa05204	2.01081217
16	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.00023771
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.89953853
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.86866800
19	Retinol metabolism_Homo sapiens_hsa00830	1.84708961
20	Propanoate metabolism_Homo sapiens_hsa00640	1.82884858
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.79430397
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.78936429
23	Peroxisome_Homo sapiens_hsa04146	1.73851069
24	Fatty acid elongation_Homo sapiens_hsa00062	1.72581369
25	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.70824742
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.70009782
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.64632149
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.62475734
29	Pyruvate metabolism_Homo sapiens_hsa00620	1.61237918
30	Tyrosine metabolism_Homo sapiens_hsa00350	1.59257829
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.46105828
32	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.39976216
33	Arginine and proline metabolism_Homo sapiens_hsa00330	1.38539108
34	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.38435290
35	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.37510691
36	Glutathione metabolism_Homo sapiens_hsa00480	1.36148095
37	PPAR signaling pathway_Homo sapiens_hsa03320	1.35896545
38	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.35765760
39	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.33866776
40	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.30266219
41	Sulfur metabolism_Homo sapiens_hsa00920	1.28352982
42	Sphingolipid metabolism_Homo sapiens_hsa00600	1.26468984
43	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.25251969
44	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.22565250
45	Folate biosynthesis_Homo sapiens_hsa00790	1.22132164
46	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.21641963
47	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.16428695
48	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.10033378
49	Steroid biosynthesis_Homo sapiens_hsa00100	1.06794669
50	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.06606229
51	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.04071910
52	Bile secretion_Homo sapiens_hsa04976	1.02602205
53	Carbon metabolism_Homo sapiens_hsa01200	1.00190680
54	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.99126563
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98039637
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.97254396
57	Caffeine metabolism_Homo sapiens_hsa00232	0.93795655
58	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.93723886
59	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.89937936
60	Protein export_Homo sapiens_hsa03060	0.89578615
61	Other glycan degradation_Homo sapiens_hsa00511	0.85794287
62	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.81117594
63	Proteasome_Homo sapiens_hsa03050	0.80117975
64	Metabolic pathways_Homo sapiens_hsa01100	0.79538652
65	Galactose metabolism_Homo sapiens_hsa00052	0.77976730
66	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75277730
67	Sulfur relay system_Homo sapiens_hsa04122	0.73242814
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.69319554
69	Glycerolipid metabolism_Homo sapiens_hsa00561	0.67538202
70	One carbon pool by folate_Homo sapiens_hsa00670	0.65983193
71	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65600935
72	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.65349974
73	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.65301133
74	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.63638130
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.60813684
76	Parkinsons disease_Homo sapiens_hsa05012	0.58425360
77	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57947239
78	Huntingtons disease_Homo sapiens_hsa05016	0.53810892
79	Lysine degradation_Homo sapiens_hsa00310	0.52233144
80	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47243948
81	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47164824
82	Phototransduction_Homo sapiens_hsa04744	0.43928286
83	ABC transporters_Homo sapiens_hsa02010	0.43641147
84	Selenocompound metabolism_Homo sapiens_hsa00450	0.42464575
85	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.40591969
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.39403349
87	Mismatch repair_Homo sapiens_hsa03430	0.34277897
88	RNA polymerase_Homo sapiens_hsa03020	0.33948383
89	Alzheimers disease_Homo sapiens_hsa05010	0.33767968
90	Mineral absorption_Homo sapiens_hsa04978	0.33602309
91	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.33232948
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.28230155
93	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.21534911
94	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.19082604
95	Adherens junction_Homo sapiens_hsa04520	0.14933520
96	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.14726671
97	Pentose phosphate pathway_Homo sapiens_hsa00030	0.13358028
98	Collecting duct acid secretion_Homo sapiens_hsa04966	0.12657934
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.12333875
100	Taste transduction_Homo sapiens_hsa04742	0.12056373

ABCC6P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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