ABCD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.07601030
2L-phenylalanine catabolic process (GO:0006559)7.07601030
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.74036511
4L-phenylalanine metabolic process (GO:0006558)6.74036511
5aromatic amino acid family catabolic process (GO:0009074)6.20293137
6alpha-linolenic acid metabolic process (GO:0036109)5.59856992
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.50851976
8tryptophan catabolic process (GO:0006569)5.45719991
9indole-containing compound catabolic process (GO:0042436)5.45719991
10indolalkylamine catabolic process (GO:0046218)5.45719991
11glyoxylate metabolic process (GO:0046487)5.43797104
12bile acid biosynthetic process (GO:0006699)5.41051741
13kynurenine metabolic process (GO:0070189)5.30476116
14cysteine metabolic process (GO:0006534)5.20565876
15tryptophan metabolic process (GO:0006568)5.19838508
16sulfur amino acid catabolic process (GO:0000098)5.11843820
17fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.87069127
18urea cycle (GO:0000050)4.83923896
19urea metabolic process (GO:0019627)4.83923896
20high-density lipoprotein particle remodeling (GO:0034375)4.80077978
21lysine catabolic process (GO:0006554)4.75395303
22lysine metabolic process (GO:0006553)4.75395303
23bile acid metabolic process (GO:0008206)4.71508614
24protein carboxylation (GO:0018214)4.68772673
25peptidyl-glutamic acid carboxylation (GO:0017187)4.68772673
26negative regulation of fibrinolysis (GO:0051918)4.60161129
27negative regulation of protein localization to cell surface (GO:2000009)4.56161383
28regulation of sarcomere organization (GO:0060297)4.54459675
29homocysteine metabolic process (GO:0050667)4.53860717
30complement activation, alternative pathway (GO:0006957)4.52774444
31aromatic amino acid family metabolic process (GO:0009072)4.52284533
32serine family amino acid catabolic process (GO:0009071)4.50876781
33cellular ketone body metabolic process (GO:0046950)4.50031422
34nitrogen cycle metabolic process (GO:0071941)4.45997585
35amino-acid betaine metabolic process (GO:0006577)4.45932903
36regulation of fibrinolysis (GO:0051917)4.44990634
37tyrosine metabolic process (GO:0006570)4.44400126
38regulation of protein activation cascade (GO:2000257)4.41839423
39regulation of triglyceride catabolic process (GO:0010896)4.37913638
40reverse cholesterol transport (GO:0043691)4.27724809
41alpha-amino acid catabolic process (GO:1901606)4.27151367
42acylglycerol homeostasis (GO:0055090)4.17840143
43triglyceride homeostasis (GO:0070328)4.17840143
44regulation of cholesterol esterification (GO:0010872)4.17648994
45macromolecular complex remodeling (GO:0034367)4.13630072
46plasma lipoprotein particle remodeling (GO:0034369)4.13630072
47protein-lipid complex remodeling (GO:0034368)4.13630072
48primary alcohol catabolic process (GO:0034310)4.13607088
49regulation of complement activation (GO:0030449)4.13516157
50coenzyme catabolic process (GO:0009109)4.12731905
51bile acid and bile salt transport (GO:0015721)4.11090136
52cellular glucuronidation (GO:0052695)4.10735561
53phospholipid efflux (GO:0033700)4.08950773
54short-chain fatty acid metabolic process (GO:0046459)4.08524630
55drug catabolic process (GO:0042737)4.05247916
56cellular amino acid catabolic process (GO:0009063)4.03188505
57glutamate metabolic process (GO:0006536)4.00379455
58negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.00347469
59ethanol oxidation (GO:0006069)3.97358344
60indolalkylamine metabolic process (GO:0006586)3.96951815
61negative regulation of sterol transport (GO:0032372)3.96260845
62negative regulation of cholesterol transport (GO:0032375)3.96260845
63drug transmembrane transport (GO:0006855)3.95142666
64ketone body metabolic process (GO:1902224)3.93313956
65cellular modified amino acid catabolic process (GO:0042219)3.90262230
66plasma lipoprotein particle clearance (GO:0034381)3.87076562
67acetyl-CoA metabolic process (GO:0006084)3.86532253
68benzene-containing compound metabolic process (GO:0042537)3.81780224
69cholesterol efflux (GO:0033344)3.80478723
70cellular biogenic amine catabolic process (GO:0042402)3.78903294
71amine catabolic process (GO:0009310)3.78903294
72regulation of cholesterol homeostasis (GO:2000188)3.76245156
73glucuronate metabolic process (GO:0019585)3.75622058
74uronic acid metabolic process (GO:0006063)3.75622058
75serine family amino acid metabolic process (GO:0009069)3.72797454
76* fatty acid beta-oxidation (GO:0006635)3.70457149
77ethanol metabolic process (GO:0006067)3.69706243
78* organic acid catabolic process (GO:0016054)3.67153787
79* carboxylic acid catabolic process (GO:0046395)3.67153787
80* fatty acid oxidation (GO:0019395)3.66658526
81epoxygenase P450 pathway (GO:0019373)3.65924487
82ribonucleoprotein complex disassembly (GO:0032988)3.65191808
83plasma membrane repair (GO:0001778)3.62373230
84imidazole-containing compound metabolic process (GO:0052803)3.62077321
85aspartate family amino acid catabolic process (GO:0009068)3.61113382
86* monocarboxylic acid catabolic process (GO:0072329)3.60948299
87* lipid oxidation (GO:0034440)3.59800643
88phospholipid homeostasis (GO:0055091)3.58162458
89regulation of bile acid biosynthetic process (GO:0070857)3.56843620
90glycine metabolic process (GO:0006544)3.56520991
91* fatty acid catabolic process (GO:0009062)3.56130930
92dicarboxylic acid biosynthetic process (GO:0043650)3.52948571
93plasma lipoprotein particle assembly (GO:0034377)3.52480599
94aldehyde catabolic process (GO:0046185)3.50710846
95negative regulation of lipase activity (GO:0060192)3.49446633
96positive regulation of lipid catabolic process (GO:0050996)3.48820859
97flavonoid metabolic process (GO:0009812)3.47488636
98carnitine metabolic process (GO:0009437)3.47177579
99cholesterol homeostasis (GO:0042632)3.46173711
100intestinal cholesterol absorption (GO:0030299)3.43034491
101positive regulation of fatty acid beta-oxidation (GO:0032000)3.42790202
102exogenous drug catabolic process (GO:0042738)3.42556800
103regulation of cholesterol metabolic process (GO:0090181)3.42529627
104sterol homeostasis (GO:0055092)3.42368583
105urate metabolic process (GO:0046415)3.42181245
106low-density lipoprotein particle remodeling (GO:0034374)3.42120236
107very-low-density lipoprotein particle assembly (GO:0034379)3.41735625
108response to nitrosative stress (GO:0051409)3.40913179
109negative regulation of potassium ion transmembrane transport (GO:1901380)3.33175689
110COPII vesicle coating (GO:0048208)3.14707564
111desmosome organization (GO:0002934)3.10570754
112negative regulation of protein activation cascade (GO:2000258)3.05955396
113positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.98940091
114polyketide metabolic process (GO:0030638)2.97294000
115doxorubicin metabolic process (GO:0044598)2.97294000
116daunorubicin metabolic process (GO:0044597)2.97294000
117midgut development (GO:0007494)2.96522552
118organelle disassembly (GO:1903008)2.92206678
119omega-hydroxylase P450 pathway (GO:0097267)2.89091458
120regulation of skeletal muscle contraction (GO:0014819)2.87605564
121negative regulation of heart growth (GO:0061117)2.86047022
122negative regulation of cardiac muscle tissue growth (GO:0055022)2.86047022
123intestinal absorption (GO:0050892)2.85378529
124regulation of transforming growth factor beta2 production (GO:0032909)2.81210521
125aminoglycoside antibiotic metabolic process (GO:0030647)2.73058119
126embryonic foregut morphogenesis (GO:0048617)2.73034956
127negative regulation of complement activation (GO:0045916)2.71397897
128negative regulation of nitric-oxide synthase activity (GO:0051001)2.66003143
129ventricular cardiac muscle cell action potential (GO:0086005)2.63348448
130membrane assembly (GO:0071709)2.61956386
131negative regulation of muscle hypertrophy (GO:0014741)2.55853341
132polyol biosynthetic process (GO:0046173)2.54133115
133drug metabolic process (GO:0017144)2.52436361
134negative regulation of cardiac muscle tissue development (GO:0055026)2.52191920
135glutamine family amino acid biosynthetic process (GO:0009084)2.48666644
136muscle cell cellular homeostasis (GO:0046716)2.47403805
137regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.46280629
138primary alcohol metabolic process (GO:0034308)2.46118457
139oxidative demethylation (GO:0070989)2.45144831
140activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.44567421
141Golgi transport vesicle coating (GO:0048200)2.42363652
142COPI coating of Golgi vesicle (GO:0048205)2.42363652
143cholesterol biosynthetic process (GO:0006695)2.42027920
144bundle of His cell to Purkinje myocyte communication (GO:0086069)2.41985493
145mitotic sister chromatid cohesion (GO:0007064)2.41967170
146peroxisome fission (GO:0016559)2.38271369
147regulation of protein localization to cell surface (GO:2000008)2.34421807
148regulation of sister chromatid cohesion (GO:0007063)2.34326633
149postreplication repair (GO:0006301)2.27798715
150nuclear pore complex assembly (GO:0051292)2.26359538
151negative regulation of organelle assembly (GO:1902116)2.22494905
152heme transport (GO:0015886)2.19238456
153eye photoreceptor cell differentiation (GO:0001754)2.18581659
154photoreceptor cell differentiation (GO:0046530)2.18581659
155membrane budding (GO:0006900)2.18361303

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.41460581
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.36943417
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.94731116
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.80065186
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.75520746
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.72046182
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.17074625
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.79671386
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.20725532
10AR_21909140_ChIP-Seq_LNCAP_Human2.95584097
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50110967
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.49415653
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.42268609
14E2F7_22180533_ChIP-Seq_HELA_Human2.36804131
15IGF1R_20145208_ChIP-Seq_DFB_Human2.32962499
16PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.18258128
17VDR_22108803_ChIP-Seq_LS180_Human2.13628913
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09565092
19FUS_26573619_Chip-Seq_HEK293_Human2.01877290
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.3208370
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.89873633
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.88327054
23CLOCK_20551151_ChIP-Seq_293T_Human1.83369379
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.75735208
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75125151
26* FOXA2_19822575_ChIP-Seq_HepG2_Human1.71163171
27GBX2_23144817_ChIP-Seq_PC3_Human1.69460861
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68603098
29SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.63504360
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.62823246
31OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58615745
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53124652
33SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51209372
34GATA1_22025678_ChIP-Seq_K562_Human1.49607685
35MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.49031113
36PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40992099
37HTT_18923047_ChIP-ChIP_STHdh_Human1.40051729
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39513114
39TP53_18474530_ChIP-ChIP_U2OS_Human1.38430552
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36932555
41* HNF4A_19822575_ChIP-Seq_HepG2_Human1.35286213
42TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.34316936
43SMAD4_21799915_ChIP-Seq_A2780_Human1.33376745
44EZH2_27294783_Chip-Seq_NPCs_Mouse1.30746478
45EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30713437
46* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27998102
47* P300_19829295_ChIP-Seq_ESCs_Human1.27444717
48ZNF274_21170338_ChIP-Seq_K562_Hela1.26828800
49* NANOG_18555785_Chip-Seq_ESCs_Mouse1.24700668
50TCF4_18268006_ChIP-ChIP_LS174T_Human1.24507259
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.24064625
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24003927
53* CJUN_26792858_Chip-Seq_BT549_Human1.23854152
54EWS_26573619_Chip-Seq_HEK293_Human1.23819412
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.21277545
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20178882
57P53_22387025_ChIP-Seq_ESCs_Mouse1.19421021
58ELK1_19687146_ChIP-ChIP_HELA_Human1.18332274
59GATA4_25053715_ChIP-Seq_YYC3_Human1.17695567
60* E2F1_18555785_Chip-Seq_ESCs_Mouse1.16472143
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16213838
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.15940338
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14796632
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14664363
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14042896
66TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12270815
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.11837030
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.11727888
69STAT3_23295773_ChIP-Seq_U87_Human1.11665466
70PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11580740
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11272713
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11272713
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10656963
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10369360
75* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08874840
76* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08352761
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.07978823
78WT1_19549856_ChIP-ChIP_CCG9911_Human1.07370267
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05668906
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05543904
81* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.05004476
82* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04491684
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04435866
84* CMYC_18555785_Chip-Seq_ESCs_Mouse1.04137066
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.03815973
86AHR_22903824_ChIP-Seq_MCF-7_Human1.03734554
87* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03131740
88CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02929369
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02661769
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.01646435
91YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01261744
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.00694123
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00693949
94IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00006579
95CBP_20019798_ChIP-Seq_JUKART_Human1.00006579
96P300_18555785_Chip-Seq_ESCs_Mouse0.99896351
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99600597
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99480992
99NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98860528
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.98418343
101STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.92920091
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91049534
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89314391
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88062684
105* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86652148
106RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85459214
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.85206162
108SOX2_20726797_ChIP-Seq_SW620_Human0.83589264
109FOXA1_25552417_ChIP-Seq_VCAP_Human0.81541129
110PIAS1_25552417_ChIP-Seq_VCAP_Human0.80482950
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.79821978
112AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79669165
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.78946189
114Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76012927
115ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75706460
116PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75577984
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.74910826
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.73711487
119BCAT_22108803_ChIP-Seq_LS180_Human0.72085999
120ZNF263_19887448_ChIP-Seq_K562_Human0.70854610
121ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.69906496
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69020363
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68036894
124GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.67325418
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.66273209
126CDX2_19796622_ChIP-Seq_MESCs_Mouse0.65038751
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.64105367
128ESR1_15608294_ChIP-ChIP_MCF-7_Human0.61798966
129CBP_21632823_ChIP-Seq_H3396_Human0.61156197
130* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.60619144
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.60591665
132* GATA6_25053715_ChIP-Seq_YYC3_Human0.59999630
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.59977378
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58507842
135AR_20517297_ChIP-Seq_VCAP_Human0.58284392
136EGR1_19032775_ChIP-ChIP_M12_Human0.57649145
137FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.56796222
138RAD21_21589869_ChIP-Seq_MESCs_Mouse0.55664964
139* TP63_23658742_ChIP-Seq_EP156T_Human0.54817342
140BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.54390068
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.54147498
142IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.53985129
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.53820766
144* CDX2_22108803_ChIP-Seq_LS180_Human0.53578585
145MYC_19915707_ChIP-ChIP_AK7_Human0.53322161
146TBX20_22080862_ChIP-Seq_HEART_Mouse0.53194040
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.53194040
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.53028785
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.53019891
150TAF15_26573619_Chip-Seq_HEK293_Human0.52987587
151FOXM1_26456572_ChIP-Seq_MCF-7_Human0.51912020
152GATA1_19941826_ChIP-Seq_K562_Human0.51780768
153* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.51510217
154SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.50847649
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.49747996
156* CEBPB_22108803_ChIP-Seq_LS180_Human0.48925647
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.48836576
158PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.48827515
159NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.48649446
160STAT1_17558387_ChIP-Seq_HELA_Human0.48559942
161PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.48092701
162GATA2_19941826_ChIP-Seq_K562_Human0.47113761
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.46885287
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.46546903
165ESET_19884257_ChIP-Seq_ESCs_Mouse0.46420671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.95131850
2MP0005360_urolithiasis7.09761965
3MP0005085_abnormal_gallbladder_physiolo6.10135215
4MP0005365_abnormal_bile_salt5.94060753
5MP0008875_abnormal_xenobiotic_pharmacok4.91511798
6MP0003950_abnormal_plasma_membrane4.00903167
7MP0003806_abnormal_nucleotide_metabolis3.90047110
8MP0003252_abnormal_bile_duct3.88541708
9MP0010329_abnormal_lipoprotein_level3.35735226
10MP0003195_calcinosis3.25657596
11MP0005083_abnormal_biliary_tract2.99306139
12MP0005332_abnormal_amino_acid2.88899655
13MP0009840_abnormal_foam_cell2.88839305
14MP0001666_abnormal_nutrient_absorption2.82489076
15MP0010352_gastrointestinal_tract_polyps2.27744581
16MP0004019_abnormal_vitamin_homeostasis2.22700647
17MP0002118_abnormal_lipid_homeostasis2.20455821
18MP0003191_abnormal_cellular_cholesterol2.16855933
19MP0000609_abnormal_liver_physiology1.99713807
20MP0002138_abnormal_hepatobiliary_system1.94009523
21MP0004272_abnormal_basement_membrane1.88560549
22MP0005187_abnormal_penis_morphology1.87224099
23MP0003868_abnormal_feces_composition1.85048396
24MP0000751_myopathy1.76427096
25MP0004270_analgesia1.70123315
26MP0005319_abnormal_enzyme/_coenzyme1.68273482
27MP0002102_abnormal_ear_morphology1.55768710
28MP0009643_abnormal_urine_homeostasis1.55379720
29MP0002009_preneoplasia1.53706873
30MP0005584_abnormal_enzyme/coenzyme_acti1.53324307
31MP0000749_muscle_degeneration1.51490819
32MP0005623_abnormal_meninges_morphology1.49808566
33MP0004084_abnormal_cardiac_muscle1.48543490
34MP0005451_abnormal_body_composition1.44912430
35MP0001764_abnormal_homeostasis1.44288578
36MP0004043_abnormal_pH_regulation1.32532621
37MP0010678_abnormal_skin_adnexa1.30388457
38MP0003941_abnormal_skin_development1.29717101
39MP0008057_abnormal_DNA_replication1.21250663
40MP0009697_abnormal_copulation1.18628288
41MP0003186_abnormal_redox_activity1.18018785
42MP0003718_maternal_effect1.17597957
43MP0000647_abnormal_sebaceous_gland1.14326131
44MP0010094_abnormal_chromosome_stability1.13120334
45MP0004215_abnormal_myocardial_fiber1.12658239
46MP0005636_abnormal_mineral_homeostasis1.12258806
47MP0003011_delayed_dark_adaptation1.09766610
48MP0005330_cardiomyopathy1.09468421
49MP0000537_abnormal_urethra_morphology1.05420307
50MP0002234_abnormal_pharynx_morphology1.04863598
51MP0002233_abnormal_nose_morphology1.03852193
52MP0002078_abnormal_glucose_homeostasis1.03003358
53MP0000604_amyloidosis1.01527509
54MP0005220_abnormal_exocrine_pancreas1.00203725
55MP0005647_abnormal_sex_gland0.99430296
56MP0005408_hypopigmentation0.98457162
57MP0003705_abnormal_hypodermis_morpholog0.98384151
58MP0000598_abnormal_liver_morphology0.97968926
59MP0002254_reproductive_system_inflammat0.97573584
60MP0001299_abnormal_eye_distance/0.95594215
61MP0005670_abnormal_white_adipose0.95170312
62MP0002697_abnormal_eye_size0.94787752
63MP0004130_abnormal_muscle_cell0.94637216
64MP0001293_anophthalmia0.94132140
65MP0002269_muscular_atrophy0.93620254
66MP0003385_abnormal_body_wall0.93455872
67MP0002876_abnormal_thyroid_physiology0.92997101
68MP0001756_abnormal_urination0.91870335
69MP0000467_abnormal_esophagus_morphology0.90671798
70MP0002896_abnormal_bone_mineralization0.88428874
71MP0006036_abnormal_mitochondrial_physio0.88352719
72MP0006138_congestive_heart_failure0.87976488
73MP0003329_amyloid_beta_deposits0.86915565
74MP0005535_abnormal_body_temperature0.86373770
75MP0003221_abnormal_cardiomyocyte_apopto0.86338276
76MP0002971_abnormal_brown_adipose0.86080767
77MP0003656_abnormal_erythrocyte_physiolo0.85846368
78MP0002092_abnormal_eye_morphology0.85064271
79MP0009642_abnormal_blood_homeostasis0.84736254
80MP0005084_abnormal_gallbladder_morpholo0.83782268
81MP0002837_dystrophic_cardiac_calcinosis0.82538832
82MP0009780_abnormal_chondrocyte_physiolo0.80495239
83MP0003937_abnormal_limbs/digits/tail_de0.80320494
84MP0000462_abnormal_digestive_system0.80207523
85MP0000383_abnormal_hair_follicle0.79831770
86MP0003690_abnormal_glial_cell0.79609256
87MP0001915_intracranial_hemorrhage0.78912575
88MP0010234_abnormal_vibrissa_follicle0.78642188
89MP0005409_darkened_coat_color0.78632798
90MP0009764_decreased_sensitivity_to0.77592770
91MP0010368_abnormal_lymphatic_system0.76032328
92MP0004782_abnormal_surfactant_physiolog0.75824195
93MP0001661_extended_life_span0.75512129
94MP0002796_impaired_skin_barrier0.75020228
95MP0009763_increased_sensitivity_to0.74707606
96MP0002877_abnormal_melanocyte_morpholog0.73502999
97MP0005334_abnormal_fat_pad0.73302929
98MP0004036_abnormal_muscle_relaxation0.71053044
99MP0000762_abnormal_tongue_morphology0.71045475
100MP0002282_abnormal_trachea_morphology0.69925111
101MP0003566_abnormal_cell_adhesion0.69921785
102MP0008058_abnormal_DNA_repair0.69330197
103MP0004957_abnormal_blastocyst_morpholog0.68844571
104MP0000377_abnormal_hair_follicle0.68830565
105MP0005376_homeostasis/metabolism_phenot0.67852973
106MP0008932_abnormal_embryonic_tissue0.67807620
107MP0002938_white_spotting0.67329129
108MP0010030_abnormal_orbit_morphology0.67002750
109MP0002972_abnormal_cardiac_muscle0.66650813
110MP0004484_altered_response_of0.66287022
111MP0003111_abnormal_nucleus_morphology0.65812488
112MP0005448_abnormal_energy_balance0.65067344
113MP0009384_cardiac_valve_regurgitation0.64659724
114MP0005666_abnormal_adipose_tissue0.64534073
115MP0002638_abnormal_pupillary_reflex0.63748674
116MP0008469_abnormal_protein_level0.63361676
117MP0009765_abnormal_xenobiotic_induced0.62943120
118MP0008775_abnormal_heart_ventricle0.62495423
119MP0003935_abnormal_craniofacial_develop0.62279460
120MP0010307_abnormal_tumor_latency0.61774536
121MP0001765_abnormal_ion_homeostasis0.60399592
122MP0003567_abnormal_fetal_cardiomyocyte0.59822168
123MP0002084_abnormal_developmental_patter0.59772695
124MP0005391_vision/eye_phenotype0.58401907
125MP0005058_abnormal_lysosome_morphology0.57873141
126MP0001270_distended_abdomen0.57844782
127MP0002136_abnormal_kidney_physiology0.57824223
128MP0005266_abnormal_metabolism0.57808379
129MP0000639_abnormal_adrenal_gland0.57541873
130MP0003953_abnormal_hormone_level0.57305465
131MP0005367_renal/urinary_system_phenotyp0.57079014
132MP0000516_abnormal_urinary_system0.57079014
133MP0004264_abnormal_extraembryonic_tissu0.56962266
134MP0003693_abnormal_embryo_hatching0.56283920
135MP0001944_abnormal_pancreas_morphology0.56220213
136MP0005501_abnormal_skin_physiology0.55977106
137MP0005248_abnormal_Harderian_gland0.55354974
138MP0000230_abnormal_systemic_arterial0.55020421
139MP0000579_abnormal_nail_morphology0.54892398
140MP0002928_abnormal_bile_duct0.52293213
141MP0006035_abnormal_mitochondrial_morpho0.49605264
142MP0002168_other_aberrant_phenotype0.47219995
143MP0003300_gastrointestinal_ulcer0.47145158
144MP0009053_abnormal_anal_canal0.46587635
145MP0005395_other_phenotype0.43422765
146MP0002822_catalepsy0.42356420
147MP0003638_abnormal_response/metabolism_0.41730174
148MP0000538_abnormal_urinary_bladder0.38717141
149MP0002090_abnormal_vision0.37552878
150MP0002295_abnormal_pulmonary_circulatio0.37213268
151MP0003959_abnormal_lean_body0.36329948
152MP0000566_synostosis0.34793928
153MP0002060_abnormal_skin_morphology0.34550783
154MP0005375_adipose_tissue_phenotype0.34475304
155MP0002693_abnormal_pancreas_physiology0.34242237
156MP0004185_abnormal_adipocyte_glucose0.33375889
157MP0001881_abnormal_mammary_gland0.33332755
158MP0004381_abnormal_hair_follicle0.32632393
159MP0002098_abnormal_vibrissa_morphology0.32395170
160MP0009672_abnormal_birth_weight0.31504196
161MP0002909_abnormal_adrenal_gland0.30997854
162MP0001177_atelectasis0.30769493
163MP0000427_abnormal_hair_cycle0.29210031

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)6.94526642
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.87914030
3Deep venous thrombosis (HP:0002625)6.30347601
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.96586700
5Xanthomatosis (HP:0000991)5.90540418
6Hypobetalipoproteinemia (HP:0003563)5.66941056
7Prolonged partial thromboplastin time (HP:0003645)5.57033101
8Exercise-induced muscle cramps (HP:0003710)4.97862338
9Hyperlipoproteinemia (HP:0010980)4.94003728
10Hypoglycemic coma (HP:0001325)4.73658557
11Ketosis (HP:0001946)4.58905087
12Complement deficiency (HP:0004431)4.52544849
13Calf muscle hypertrophy (HP:0008981)4.52309884
14Hyperammonemia (HP:0001987)4.46899316
15Epidermoid cyst (HP:0200040)4.35261286
16Hyperglycinemia (HP:0002154)4.33949895
17Hyperglycinuria (HP:0003108)4.32968441
18Hypolipoproteinemia (HP:0010981)4.31724735
19Abnormality of serine family amino acid metabolism (HP:0010894)4.17769783
20Abnormality of glycine metabolism (HP:0010895)4.17769783
21Abnormality of glutamine family amino acid metabolism (HP:0010902)4.14910975
22Fat malabsorption (HP:0002630)4.04445343
23Subaortic stenosis (HP:0001682)4.00902357
24Abnormality of the left ventricular outflow tract (HP:0011103)4.00902357
25Exercise-induced myalgia (HP:0003738)3.99468648
26Conjugated hyperbilirubinemia (HP:0002908)3.99126857
27Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.97376709
28Abnormality of the common coagulation pathway (HP:0010990)3.93723609
29Abnormality of aspartate family amino acid metabolism (HP:0010899)3.92910008
30Ketoacidosis (HP:0001993)3.90736067
31Joint hemorrhage (HP:0005261)3.88911207
32Muscle hypertrophy of the lower extremities (HP:0008968)3.86165939
33Increased serum pyruvate (HP:0003542)3.86091230
34Abnormality of sulfur amino acid metabolism (HP:0004339)3.85912734
35Hypoalphalipoproteinemia (HP:0003233)3.79521165
36Abnormality of methionine metabolism (HP:0010901)3.72095850
37Abnormality of fatty-acid metabolism (HP:0004359)3.63461277
38Abnormality of the intrinsic pathway (HP:0010989)3.54695183
39Abnormality of glycolysis (HP:0004366)3.53675587
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.42591127
41Hypoglycemic seizures (HP:0002173)3.28937227
42Gout (HP:0001997)3.28293513
43Hypercholesterolemia (HP:0003124)3.26117363
44Abnormality of complement system (HP:0005339)3.19157528
45Hyperbilirubinemia (HP:0002904)3.16994911
46Abnormality of purine metabolism (HP:0004352)3.13096737
47Delayed CNS myelination (HP:0002188)3.08605085
48Abnormality of nucleobase metabolism (HP:0010932)3.02036021
49Arterial tortuosity (HP:0005116)2.95823382
50Metabolic acidosis (HP:0001942)2.92046949
51Steatorrhea (HP:0002570)2.91932673
52Dicarboxylic aciduria (HP:0003215)2.90323200
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90323200
54Skin nodule (HP:0200036)2.88410827
55Generalized aminoaciduria (HP:0002909)2.88293823
56Hyperinsulinemic hypoglycemia (HP:0000825)2.87305655
57Abnormality of serum amino acid levels (HP:0003112)2.85563894
58Abnormality of pyrimidine metabolism (HP:0004353)2.79914590
59Hepatocellular carcinoma (HP:0001402)2.70387412
60Vascular tortuosity (HP:0004948)2.69767628
61Lethargy (HP:0001254)2.64780710
62Abnormality of the calf musculature (HP:0001430)2.59735473
63Asymmetric septal hypertrophy (HP:0001670)2.59687815
64Sudden death (HP:0001699)2.59382574
65Vascular calcification (HP:0004934)2.54703177
66Symptomatic seizures (HP:0011145)2.51949936
67Myocardial infarction (HP:0001658)2.44643945
68Papillary thyroid carcinoma (HP:0002895)2.43835293
69Irritability (HP:0000737)2.42325048
70Late onset (HP:0003584)2.41918718
71Cerebral edema (HP:0002181)2.40455669
72Acanthocytosis (HP:0001927)2.39395239
73Malnutrition (HP:0004395)2.36448449
74Proximal tubulopathy (HP:0000114)2.35391963
75Sensorimotor neuropathy (HP:0007141)2.34252928
76Abnormal gallbladder morphology (HP:0012437)2.34144100
77Hyperglycemia (HP:0003074)2.33185470
78Enlarged kidneys (HP:0000105)2.31056065
79Popliteal pterygium (HP:0009756)2.30928304
80Alkalosis (HP:0001948)2.30712069
81Abnormality of urine glucose concentration (HP:0011016)2.28455238
82Glycosuria (HP:0003076)2.28455238
83Cardiovascular calcification (HP:0011915)2.26083712
84Hypochromic microcytic anemia (HP:0004840)2.23891772
85Spastic diplegia (HP:0001264)2.23528114
86Increased purine levels (HP:0004368)2.23290873
87Hyperuricemia (HP:0002149)2.23290873
88Vomiting (HP:0002013)2.22947993
89Spontaneous abortion (HP:0005268)2.21881303
90Systemic lupus erythematosus (HP:0002725)2.21278109
91Pancreatitis (HP:0001733)2.21261756
92Abnormality of proline metabolism (HP:0010907)2.18189706
93Hydroxyprolinuria (HP:0003080)2.18189706
94Rickets (HP:0002748)2.12867538
95Cholelithiasis (HP:0001081)2.12770438
96Neonatal onset (HP:0003623)2.05591103
97Abnormality of the astrocytes (HP:0100707)2.05360040
98Astrocytoma (HP:0009592)2.05360040
99Mitral stenosis (HP:0001718)2.04932449
100Patchy hypopigmentation of hair (HP:0011365)2.00676760
101Abnormal enzyme/coenzyme activity (HP:0012379)1.98758687
102Abnormal gallbladder physiology (HP:0012438)1.98723759
103Cholecystitis (HP:0001082)1.98723759
104Esophageal varix (HP:0002040)1.98704867
105Glomerulonephritis (HP:0000099)1.97468781
106Abnormality of vitamin metabolism (HP:0100508)1.95511192
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93792856
108Amyloidosis (HP:0011034)1.93544727
109Abnormality of the gallbladder (HP:0005264)1.92915958
110Fair hair (HP:0002286)1.92627712
111Opisthotonus (HP:0002179)1.86593917
112Volvulus (HP:0002580)1.84794080
113Gowers sign (HP:0003391)1.83514066
114Thyroid carcinoma (HP:0002890)1.83004684
115Pheochromocytoma (HP:0002666)1.81591298
116Acute hepatic failure (HP:0006554)1.80926839
117Muscle stiffness (HP:0003552)1.79041548
118Elevated alkaline phosphatase (HP:0003155)1.78615622
119Pili torti (HP:0003777)1.78174416
120Decreased lacrimation (HP:0000633)1.77021643
121Abnormality of alkaline phosphatase activity (HP:0004379)1.75692251
122Hypophosphatemic rickets (HP:0004912)1.75496584
123Osteomalacia (HP:0002749)1.74916137
124Myoglobinuria (HP:0002913)1.72524760
125Abnormality of macular pigmentation (HP:0008002)1.72154093
126Hemorrhage of the eye (HP:0011885)1.72036554
127Abnormality of the pancreatic islet cells (HP:0006476)1.71546546
128Abnormality of endocrine pancreas physiology (HP:0012093)1.71546546
129Elevated hepatic transaminases (HP:0002910)1.71033025
130Overlapping toe (HP:0001845)1.67048523
131* Abnormal biliary tract morphology (HP:0012440)1.66031741
132Right ventricular cardiomyopathy (HP:0011663)1.65857025
133Termporal pattern (HP:0011008)1.65291256
134Insidious onset (HP:0003587)1.65291256
135Abnormal auditory evoked potentials (HP:0006958)1.64944000
136Tubulointerstitial nephritis (HP:0001970)1.63919003
137Abnormal tarsal ossification (HP:0008369)1.63116357
138Bifid scrotum (HP:0000048)1.62107395
139Abnormal foot bone ossification (HP:0010675)1.60911313
140Myotonia (HP:0002486)1.60486848
141Asymmetry of the thorax (HP:0001555)1.58063498
142Megaloblastic anemia (HP:0001889)1.57057989
143Pterygium (HP:0001059)1.53954446
144Ependymoma (HP:0002888)1.53283620
145White forelock (HP:0002211)1.51381689
146Focal segmental glomerulosclerosis (HP:0000097)1.49772929
147Hyperactive renin-angiotensin system (HP:0000841)1.49029658
148Glioma (HP:0009733)1.48812321
149Rhinitis (HP:0012384)1.47555731
150Small epiphyses (HP:0010585)1.46684551
151Neck muscle weakness (HP:0000467)1.44489915
152Curly hair (HP:0002212)1.44282808
153Glomerulosclerosis (HP:0000096)1.43837386
154Alacrima (HP:0000522)1.42173861
155Barrel-shaped chest (HP:0001552)1.41263410
156Childhood onset (HP:0011463)1.40095323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.09040854
2INSRR4.25668742
3SIK13.84316445
4FGFR43.26446982
5ERN13.19468707
6TAOK32.77137127
7MAPKAPK52.54865017
8FRK2.54636712
9EIF2AK32.44307002
10MST1R2.43451463
11WEE12.38814834
12ERBB42.36413096
13SCYL22.34786854
14MST42.24413907
15BCR2.22985121
16BRSK22.12777984
17EIF2AK12.12434741
18WNK42.01654918
19CDK81.99779393
20CCNB11.99366176
21CASK1.98840815
22LATS11.97393675
23TRIB31.89563921
24ERBB31.86808620
25NEK11.83958138
26MAPK151.81253215
27FGFR21.78059094
28PIK3CG1.69271614
29MUSK1.63836892
30EPHB11.58834844
31PTK61.57126191
32MAP2K41.56531534
33ACVR1B1.54729762
34MET1.50740263
35WNK31.50344905
36PKN21.48668365
37STK31.46427176
38BMPR1B1.45869341
39FLT31.43864437
40EPHA21.42212668
41TRIM281.40025815
42MAP3K21.35468593
43OXSR11.32338478
44SRPK11.30330616
45DMPK1.27319152
46MAP3K121.27310289
47MAPK111.26915014
48TTK1.23566676
49PNCK1.23343281
50STK391.19432735
51MAP3K71.16179585
52PRKAA21.15516272
53PINK11.15084316
54NEK91.13801965
55STK38L1.13181646
56MELK1.09248690
57PLK21.06554098
58ERBB21.05266856
59PDK41.04322842
60PDK31.04322842
61ABL21.00257582
62PLK30.98854352
63PAK30.98326211
64MKNK20.97109752
65MAP3K40.96499497
66TNIK0.96234618
67DAPK20.94791508
68EPHA30.93474640
69SGK2230.93236202
70SGK4940.93236202
71TSSK60.93151221
72JAK20.92317917
73PTK20.92074855
74MAP3K30.88166087
75GSK3A0.87728574
76FER0.87243479
77CSNK1G30.86977984
78RIPK10.85435174
79LMTK20.84022810
80NEK60.83499550
81KSR10.83129599
82BRSK10.81227838
83CAMK1D0.80758078
84PLK10.80294128
85PRKAA10.79967822
86MAP2K70.79388960
87SGK30.79366024
88PRKCZ0.78021428
89CDC70.77739829
90PLK40.76001822
91STK240.75998540
92MKNK10.75591748
93PRKACG0.74462435
94TYK20.73240507
95SGK20.70881181
96CAMK2G0.70829434
97DYRK1B0.70824877
98JAK10.70570995
99PRKCE0.69159930
100MAP4K20.68766630
101MAP2K20.67267805
102TIE10.67206986
103CDK70.66606788
104CAMK2D0.66379963
105PDPK10.65182803
106PIK3CA0.64543564
107CDK90.63649337
108NTRK10.63043974
109PAK40.61368180
110EIF2AK20.61271323
111MYLK0.59827244
112YES10.59398698
113MAP2K10.58874850
114PRKD30.57933537
115PDGFRA0.56710226
116PRKACB0.56457473
117CSNK1D0.56356979
118MAP3K10.54462987
119EPHB20.53635289
120PBK0.53057983
121IRAK30.52334408
122PDK20.52315977
123RET0.52059239
124FGFR30.49874368
125PRKD10.48547244
126IGF1R0.48075276
127PRKCH0.47997646
128BRD40.47571134
129RPS6KA40.47309351
130PKN10.47125485
131CSNK1G10.46783446
132CSK0.46132094
133AKT20.45900428
134IRAK10.45316572
135AURKB0.45161554
136NLK0.45024009
137CDK60.44916076
138MAPK40.43989873
139CSNK1E0.43778433
140PRKCQ0.43763133
141CAMK1G0.42942543
142KDR0.42456791
143MINK10.42112389
144MAPK130.42069597
145LATS20.41919815
146MOS0.41707889
147ATM0.41487738
148OBSCN0.41329916
149MAP2K30.40578023
150CHEK20.39702269
151PAK60.38850670
152CAMK2B0.38265298
153CSNK1G20.37933321
154TBK10.37893378
155GRK10.36325526
156MAP3K140.34661736
157MAPK70.34317882
158AKT30.33919776
159PRKCA0.33811902
160ICK0.33404092
161MAP2K60.32825821
162FGFR10.32758149
163TGFBR20.31881841
164IRAK20.31282754
165PDK10.30852084
166CSNK1A1L0.30402031

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.99056806
2Nitrogen metabolism_Homo sapiens_hsa009103.32254652
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18560721
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81343589
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.79407515
6Fatty acid degradation_Homo sapiens_hsa000712.71214151
7Tryptophan metabolism_Homo sapiens_hsa003802.70488911
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69101127
9Arginine biosynthesis_Homo sapiens_hsa002202.62250373
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54451227
11Butanoate metabolism_Homo sapiens_hsa006502.46292715
12Propanoate metabolism_Homo sapiens_hsa006402.28460899
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.26444713
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22812548
15Complement and coagulation cascades_Homo sapiens_hsa046102.22045246
16Fatty acid metabolism_Homo sapiens_hsa012122.10893078
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09847609
18* Peroxisome_Homo sapiens_hsa041462.09689904
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95540921
20Sulfur metabolism_Homo sapiens_hsa009201.93712293
21PPAR signaling pathway_Homo sapiens_hsa033201.92492483
22Histidine metabolism_Homo sapiens_hsa003401.91994222
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.80241239
24Chemical carcinogenesis_Homo sapiens_hsa052041.79368524
25beta-Alanine metabolism_Homo sapiens_hsa004101.74887287
26Fatty acid elongation_Homo sapiens_hsa000621.74779107
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.73944500
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.72258288
29Caffeine metabolism_Homo sapiens_hsa002321.64348093
30Retinol metabolism_Homo sapiens_hsa008301.56358200
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56091227
32Pyruvate metabolism_Homo sapiens_hsa006201.53466810
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53277498
34Selenocompound metabolism_Homo sapiens_hsa004501.52153069
35Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52025774
36Bile secretion_Homo sapiens_hsa049761.50732252
37Drug metabolism - other enzymes_Homo sapiens_hsa009831.48538199
38Phenylalanine metabolism_Homo sapiens_hsa003601.46916201
39Starch and sucrose metabolism_Homo sapiens_hsa005001.38654828
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35813361
41Steroid biosynthesis_Homo sapiens_hsa001001.34580354
42Tyrosine metabolism_Homo sapiens_hsa003501.34075677
43Fat digestion and absorption_Homo sapiens_hsa049751.28002174
44Staphylococcus aureus infection_Homo sapiens_hsa051501.25228090
45Carbon metabolism_Homo sapiens_hsa012001.17501327
46* ABC transporters_Homo sapiens_hsa020101.14437352
47Folate biosynthesis_Homo sapiens_hsa007901.14011440
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08600998
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.05915123
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00867402
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00657995
52Arginine and proline metabolism_Homo sapiens_hsa003300.99397602
53Biosynthesis of amino acids_Homo sapiens_hsa012300.98863673
54Vitamin digestion and absorption_Homo sapiens_hsa049770.96639043
55Non-homologous end-joining_Homo sapiens_hsa034500.84971057
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.84778953
57Lysine degradation_Homo sapiens_hsa003100.83452497
58Fatty acid biosynthesis_Homo sapiens_hsa000610.80175757
59Glycerolipid metabolism_Homo sapiens_hsa005610.78668844
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77667368
61Sulfur relay system_Homo sapiens_hsa041220.76643284
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74660285
63Glutathione metabolism_Homo sapiens_hsa004800.74219271
64Vitamin B6 metabolism_Homo sapiens_hsa007500.71721066
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67423767
66Adherens junction_Homo sapiens_hsa045200.61429373
67Mismatch repair_Homo sapiens_hsa034300.60787918
68Sphingolipid metabolism_Homo sapiens_hsa006000.59804006
69Pancreatic secretion_Homo sapiens_hsa049720.54918787
70Cell cycle_Homo sapiens_hsa041100.53459556
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51469179
72TGF-beta signaling pathway_Homo sapiens_hsa043500.51200373
73Tight junction_Homo sapiens_hsa045300.50409476
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50179059
75Metabolic pathways_Homo sapiens_hsa011000.48618374
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.46076324
77Pentose phosphate pathway_Homo sapiens_hsa000300.45465705
78Hippo signaling pathway_Homo sapiens_hsa043900.44503248
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42997854
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42766330
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41999848
82Nucleotide excision repair_Homo sapiens_hsa034200.41533048
83N-Glycan biosynthesis_Homo sapiens_hsa005100.41521370
84Galactose metabolism_Homo sapiens_hsa000520.38249064
85Oocyte meiosis_Homo sapiens_hsa041140.37882144
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36275118
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35655066
88Insulin resistance_Homo sapiens_hsa049310.33768894
89Linoleic acid metabolism_Homo sapiens_hsa005910.31275854
90Prion diseases_Homo sapiens_hsa050200.29729970
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.29135224
92One carbon pool by folate_Homo sapiens_hsa006700.28454725
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28181925
94Fructose and mannose metabolism_Homo sapiens_hsa000510.27810581
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.23088894
96Renin secretion_Homo sapiens_hsa049240.20116747
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18662867
98Glucagon signaling pathway_Homo sapiens_hsa049220.18367133
99AMPK signaling pathway_Homo sapiens_hsa041520.12366225
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07468611
101Mineral absorption_Homo sapiens_hsa049780.06903577
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06274634
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.04249425
104Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1745333
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1626798
106Circadian rhythm_Homo sapiens_hsa04710-0.1387159
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1382988
108Type II diabetes mellitus_Homo sapiens_hsa04930-0.0838790
109Protein digestion and absorption_Homo sapiens_hsa04974-0.0736111
110Regulation of autophagy_Homo sapiens_hsa04140-0.0706869
111Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0665931
112Ether lipid metabolism_Homo sapiens_hsa00565-0.0579849
113Lysosome_Homo sapiens_hsa04142-0.0504898
114Renin-angiotensin system_Homo sapiens_hsa04614-0.0388210
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0357233
116Insulin signaling pathway_Homo sapiens_hsa04910-0.0356813
117Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0235131
118Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0150170
119Protein export_Homo sapiens_hsa03060-0.0072950
120Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0015687

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