ABCF2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ATP-binding casette proteins transport various molecules across extra- and intracellular membranes. Alterations in this gene may be involved in cancer progression. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 7. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)5.03497599
2mitotic metaphase plate congression (GO:0007080)4.79978907
3purine nucleobase biosynthetic process (GO:0009113)4.79611190
4regulation of translational fidelity (GO:0006450)4.76362092
5DNA replication initiation (GO:0006270)4.75438995
6formation of translation preinitiation complex (GO:0001731)4.74208168
7nuclear pore organization (GO:0006999)4.64206080
8protein localization to kinetochore (GO:0034501)4.64031626
9DNA unwinding involved in DNA replication (GO:0006268)4.61902200
10DNA strand elongation involved in DNA replication (GO:0006271)4.56756630
11IMP biosynthetic process (GO:0006188)4.52634003
12mitotic nuclear envelope disassembly (GO:0007077)4.51891250
13nuclear pore complex assembly (GO:0051292)4.35736517
14DNA strand elongation (GO:0022616)4.34354108
15DNA replication checkpoint (GO:0000076)4.33849977
16DNA replication-dependent nucleosome assembly (GO:0006335)4.30518090
17DNA replication-dependent nucleosome organization (GO:0034723)4.30518090
18ribosome biogenesis (GO:0042254)4.23512374
19membrane disassembly (GO:0030397)4.22706924
20nuclear envelope disassembly (GO:0051081)4.22706924
21ribosome assembly (GO:0042255)4.14018918
22IMP metabolic process (GO:0046040)4.04528065
23metaphase plate congression (GO:0051310)4.04021716
24protein localization to chromosome, centromeric region (GO:0071459)3.98720876
25mitotic sister chromatid segregation (GO:0000070)3.98337012
26establishment of integrated proviral latency (GO:0075713)3.97433822
27folic acid-containing compound biosynthetic process (GO:0009396)3.92180155
28amino acid activation (GO:0043038)3.89063556
29tRNA aminoacylation (GO:0043039)3.89063556
30telomere maintenance via semi-conservative replication (GO:0032201)3.88590200
31regulation of spindle organization (GO:0090224)3.78568145
32COPI coating of Golgi vesicle (GO:0048205)3.77711553
33Golgi transport vesicle coating (GO:0048200)3.77711553
34nucleobase-containing small molecule interconversion (GO:0015949)3.76885483
35regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.76117829
36chromatin remodeling at centromere (GO:0031055)3.68965109
37mitotic chromosome condensation (GO:0007076)3.68214855
38CENP-A containing nucleosome assembly (GO:0034080)3.67076582
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61292868
40maturation of SSU-rRNA (GO:0030490)3.60324099
41pore complex assembly (GO:0046931)3.60130719
42establishment of chromosome localization (GO:0051303)3.58214262
43spliceosomal tri-snRNP complex assembly (GO:0000244)3.56784673
44telomere maintenance via recombination (GO:0000722)3.56466644
45positive regulation of chromosome segregation (GO:0051984)3.56223298
46sister chromatid segregation (GO:0000819)3.54918292
47proline biosynthetic process (GO:0006561)3.50611475
48spliceosomal snRNP assembly (GO:0000387)3.50538777
49regulation of translational termination (GO:0006449)3.49582389
50attachment of spindle microtubules to kinetochore (GO:0008608)3.48552868
51DNA replication-independent nucleosome assembly (GO:0006336)3.46510301
52DNA replication-independent nucleosome organization (GO:0034724)3.46510301
53ribonucleoprotein complex biogenesis (GO:0022613)3.44428269
54mitotic recombination (GO:0006312)3.42642933
55histone exchange (GO:0043486)3.41542760
56transcription from mitochondrial promoter (GO:0006390)3.38222210
57mitochondrial RNA metabolic process (GO:0000959)3.36409202
58nuclear envelope organization (GO:0006998)3.34536486
59regulation of chromosome segregation (GO:0051983)3.34123991
60protein maturation by protein folding (GO:0022417)3.33586768
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.32294221
62negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.30394868
63DNA duplex unwinding (GO:0032508)3.30223348
64peptidyl-arginine omega-N-methylation (GO:0035247)3.29707074
65DNA geometric change (GO:0032392)3.29295278
66negative regulation of chromosome segregation (GO:0051985)3.29160093
67telomere maintenance via telomere lengthening (GO:0010833)3.28880149
68regulation of mitochondrial translation (GO:0070129)3.28092575
69protein complex localization (GO:0031503)3.27496022
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.24694976
71negative regulation of sister chromatid segregation (GO:0033046)3.24694976
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.24694976
73negative regulation of mitotic sister chromatid segregation (GO:0033048)3.24694976
74regulation of centrosome cycle (GO:0046605)3.24102543
75establishment of viral latency (GO:0019043)3.23876237
76spindle checkpoint (GO:0031577)3.23556626
77cellular protein complex localization (GO:0034629)3.22342158
78rRNA processing (GO:0006364)3.21231312
79regulation of mitotic spindle organization (GO:0060236)3.21070317
80folic acid metabolic process (GO:0046655)3.20589033
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.19698666
82mitotic spindle assembly checkpoint (GO:0007094)3.16766895
83somatic hypermutation of immunoglobulin genes (GO:0016446)3.16520035
84somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16520035
85regulation of translational elongation (GO:0006448)3.16040421
86mitotic spindle checkpoint (GO:0071174)3.15728974
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.14878164
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14816545
89regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14406438
90spindle assembly checkpoint (GO:0071173)3.14327978
91nucleotide-excision repair, DNA gap filling (GO:0006297)3.14040783
92maturation of 5.8S rRNA (GO:0000460)3.12483583
93kinetochore organization (GO:0051383)3.12377805
94rRNA metabolic process (GO:0016072)3.12230414
95G1/S transition of mitotic cell cycle (GO:0000082)3.11695998
96cell cycle G1/S phase transition (GO:0044843)3.11695998
97cullin deneddylation (GO:0010388)3.10734765
98negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10685517
99ribosomal small subunit biogenesis (GO:0042274)3.09114707
100negative regulation of ligase activity (GO:0051352)3.08530867
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08530867
102ribosomal large subunit biogenesis (GO:0042273)3.08098187
103regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07054550
104pseudouridine synthesis (GO:0001522)3.04854212
105pteridine-containing compound biosynthetic process (GO:0042559)3.03956764
106histone arginine methylation (GO:0034969)3.03670504
107regulation of centriole replication (GO:0046599)3.03511604
108chaperone-mediated protein complex assembly (GO:0051131)3.02362657
109regulation of translation in response to stress (GO:0043555)3.01453051
110regulation of posttranscriptional gene silencing (GO:0060147)3.00632473
111regulation of gene silencing by miRNA (GO:0060964)3.00632473
112regulation of gene silencing by RNA (GO:0060966)3.00632473
113protein localization to chromosome (GO:0034502)3.00250047
114tRNA aminoacylation for protein translation (GO:0006418)2.99608896
115rRNA modification (GO:0000154)2.99353686
116regulation of mitotic sister chromatid separation (GO:0010965)2.98839447
117regulation of mitotic sister chromatid segregation (GO:0033047)2.98839447
118regulation of sister chromatid segregation (GO:0033045)2.98839447
119mitotic sister chromatid cohesion (GO:0007064)2.98557636
120chromatin assembly or disassembly (GO:0006333)2.98509283
121postreplication repair (GO:0006301)2.98248205
122heterochromatin organization (GO:0070828)2.97884772
123protein K6-linked ubiquitination (GO:0085020)2.96684950
124tRNA methylation (GO:0030488)2.95780428
125positive regulation of DNA-dependent DNA replication (GO:2000105)2.92861264
126chromosome condensation (GO:0030261)2.91651137
127rRNA transcription (GO:0009303)2.90196962
128de novo protein folding (GO:0006458)2.90156261
129rRNA methylation (GO:0031167)2.89845997
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.83720996
131double-strand break repair via nonhomologous end joining (GO:0006303)2.83287302
132non-recombinational repair (GO:0000726)2.83287302
133viral mRNA export from host cell nucleus (GO:0046784)2.81318974
134negative regulation of mRNA processing (GO:0050686)2.80526124
135nuclear envelope reassembly (GO:0031468)2.80034971
136mitotic nuclear envelope reassembly (GO:0007084)2.80034971
137de novo posttranslational protein folding (GO:0051084)2.76748020
138peptidyl-arginine N-methylation (GO:0035246)2.76581812
139peptidyl-arginine methylation (GO:0018216)2.76581812
140DNA conformation change (GO:0071103)2.74940463
141cellular component biogenesis (GO:0044085)2.74785010

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.68588788
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.38405746
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24285416
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77970554
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63053200
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16924486
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.08438585
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01728674
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.98292974
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94556597
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87459507
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.86480566
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.86367438
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.84434832
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76655462
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.59108017
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46734577
18AR_21909140_ChIP-Seq_LNCAP_Human2.36036298
19XRN2_22483619_ChIP-Seq_HELA_Human2.34264096
20* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33768495
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14922262
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.10199582
23KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08157556
24* VDR_23849224_ChIP-Seq_CD4+_Human2.07456520
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.07250714
26E2F1_21310950_ChIP-Seq_MCF-7_Human2.01532383
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95154198
28* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.94475337
29POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.93147119
30DCP1A_22483619_ChIP-Seq_HELA_Human1.92469961
31GABP_19822575_ChIP-Seq_HepG2_Human1.92435371
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.90888060
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.90200021
34FOXP3_21729870_ChIP-Seq_TREG_Human1.89977996
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79199130
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.78433997
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75722482
38TTF2_22483619_ChIP-Seq_HELA_Human1.74870305
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.71770273
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69321837
41KDM5A_27292631_Chip-Seq_BREAST_Human1.64100604
42HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63828564
43ZNF263_19887448_ChIP-Seq_K562_Human1.62243550
44CIITA_25753668_ChIP-Seq_RAJI_Human1.60912394
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60748203
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59382807
47MYC_22102868_ChIP-Seq_BL_Human1.58480039
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55041275
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45515116
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43304081
51* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42064972
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39052128
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38148865
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.37810842
55ELK1_19687146_ChIP-ChIP_HELA_Human1.37649680
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33681945
57* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.31801081
58PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29400281
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.27778707
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26627837
61* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26170805
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.26037791
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25398636
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.24486588
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24306010
66* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23231143
67DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.22460834
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21626283
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.21163281
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.19841548
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.19760462
72* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17519600
73CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15541256
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15236201
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15025556
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14715766
77SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.14490481
78TFEB_21752829_ChIP-Seq_HELA_Human1.11567278
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09530359
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08838915
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.08829141
82TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07187025
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07124526
84* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05074284
85TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04328131
86NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03130798
87TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03086107
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02036607
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01278923
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.01223368
91TP63_19390658_ChIP-ChIP_HaCaT_Human1.01111658
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01075148
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01005911
94* ATF3_27146783_Chip-Seq_COLON_Human0.97753055
95SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97500914
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97212456
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96968043
98SOX17_20123909_ChIP-Seq_XEN_Mouse0.95295693
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94932248
100CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94392085
101ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91511305
102NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90268867
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88016845
104ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87493818
105TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.86498620
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.85803778
107MYC_18940864_ChIP-ChIP_HL60_Human0.85429109
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.84680663
109NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.84155377
110FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84131599
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84026089
112ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83706309
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.82349993
114CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81170223
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78302213
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.76604711
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75587498
118ELK1_22589737_ChIP-Seq_MCF10A_Human0.74067533
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71744690
120CHD1_26751641_Chip-Seq_LNCaP_Human0.71284579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.43233097
2MP0010094_abnormal_chromosome_stability4.78142339
3MP0003111_abnormal_nucleus_morphology4.73902072
4MP0004957_abnormal_blastocyst_morpholog4.55077536
5MP0003077_abnormal_cell_cycle4.15243399
6MP0008057_abnormal_DNA_replication3.74882086
7MP0008058_abnormal_DNA_repair3.45143364
8MP0003123_paternal_imprinting3.21141438
9MP0008877_abnormal_DNA_methylation3.15400531
10MP0008007_abnormal_cellular_replicative2.92853201
11MP0001730_embryonic_growth_arrest2.90364834
12MP0008932_abnormal_embryonic_tissue2.75618122
13MP0002877_abnormal_melanocyte_morpholog2.72320909
14MP0010352_gastrointestinal_tract_polyps2.51466563
15MP0000350_abnormal_cell_proliferation2.44016950
16MP0010307_abnormal_tumor_latency2.29676606
17MP0008438_abnormal_cutaneous_collagen2.17096377
18MP0003786_premature_aging2.08969904
19MP0005380_embryogenesis_phenotype2.08614404
20MP0001672_abnormal_embryogenesis/_devel2.08614404
21MP0001697_abnormal_embryo_size2.00158768
22MP0003984_embryonic_growth_retardation1.91239585
23MP0002088_abnormal_embryonic_growth/wei1.86132634
24MP0002080_prenatal_lethality1.85666666
25MP0003950_abnormal_plasma_membrane1.85173368
26MP0003718_maternal_effect1.82396266
27MP0010030_abnormal_orbit_morphology1.77336836
28MP0009697_abnormal_copulation1.74237759
29MP0002396_abnormal_hematopoietic_system1.73133095
30MP0002085_abnormal_embryonic_tissue1.72938577
31MP0004233_abnormal_muscle_weight1.70939971
32MP0003806_abnormal_nucleotide_metabolis1.69695207
33MP0002084_abnormal_developmental_patter1.68543445
34MP0004197_abnormal_fetal_growth/weight/1.64074360
35MP0001661_extended_life_span1.60441128
36MP0005451_abnormal_body_composition1.60167226
37MP0001348_abnormal_lacrimal_gland1.57885728
38MP0002210_abnormal_sex_determination1.56083103
39MP0002086_abnormal_extraembryonic_tissu1.50619965
40MP0005501_abnormal_skin_physiology1.46533583
41MP0003705_abnormal_hypodermis_morpholog1.46248939
42MP0001929_abnormal_gametogenesis1.43162379
43MP0003646_muscle_fatigue1.40162299
44MP0001145_abnormal_male_reproductive1.38232660
45MP0000313_abnormal_cell_death1.36971152
46MP0005076_abnormal_cell_differentiation1.34158837
47MP0002653_abnormal_ependyma_morphology1.33849867
48MP0010234_abnormal_vibrissa_follicle1.32817027
49MP0000750_abnormal_muscle_regeneration1.31468984
50MP0002019_abnormal_tumor_incidence1.30469613
51MP0002160_abnormal_reproductive_system1.30466469
52MP0003121_genomic_imprinting1.27978474
53MP0003221_abnormal_cardiomyocyte_apopto1.25864384
54MP0004808_abnormal_hematopoietic_stem1.25523831
55MP0008260_abnormal_autophagy1.24636279
56MP0002269_muscular_atrophy1.24490583
57MP0000358_abnormal_cell_content/1.20735474
58MP0000653_abnormal_sex_gland1.17715643
59MP0002060_abnormal_skin_morphology1.14806689
60MP0002796_impaired_skin_barrier1.13811396
61MP0003119_abnormal_digestive_system1.13321687
62MP0004084_abnormal_cardiac_muscle1.12336805
63MP0003567_abnormal_fetal_cardiomyocyte1.12009767
64MP0003890_abnormal_embryonic-extraembry1.11039094
65MP0003941_abnormal_skin_development1.10881826
66MP0000537_abnormal_urethra_morphology1.10456667
67MP0009672_abnormal_birth_weight1.10323339
68MP0004272_abnormal_basement_membrane1.08569592
69MP0000751_myopathy1.07410942
70MP0000490_abnormal_crypts_of1.06633582
71MP0005257_abnormal_intraocular_pressure1.05335619
72MP0000762_abnormal_tongue_morphology1.03324364
73MP0001293_anophthalmia1.01003740
74MP0001346_abnormal_lacrimal_gland1.00578170
75MP0003186_abnormal_redox_activity0.99831373
76MP0003698_abnormal_male_reproductive0.97768892
77MP0003315_abnormal_perineum_morphology0.91755471
78MP0009053_abnormal_anal_canal0.91714875
79MP0004185_abnormal_adipocyte_glucose0.91597439
80MP0005410_abnormal_fertilization0.91339943
81MP0001216_abnormal_epidermal_layer0.89644466
82MP0005384_cellular_phenotype0.89231622
83MP0005330_cardiomyopathy0.89215069
84MP0002111_abnormal_tail_morphology0.89015434
85MP0005023_abnormal_wound_healing0.88381687
86MP0009333_abnormal_splenocyte_physiolog0.87840698
87MP0000678_abnormal_parathyroid_gland0.85399241
88MP0001853_heart_inflammation0.85190889
89MP0005389_reproductive_system_phenotype0.84980034
90MP0002161_abnormal_fertility/fecundity0.83796373
91MP0001243_abnormal_dermal_layer0.83510661
92MP0005621_abnormal_cell_physiology0.83279422
93MP0000579_abnormal_nail_morphology0.82511776
94MP0001849_ear_inflammation0.81698885
95MP0006035_abnormal_mitochondrial_morpho0.81018427
96MP0005171_absent_coat_pigmentation0.79234347
97MP0000467_abnormal_esophagus_morphology0.77980335
98MP0009703_decreased_birth_body0.77363043
99MP0003385_abnormal_body_wall0.77280064
100MP0005266_abnormal_metabolism0.77062031
101MP0005397_hematopoietic_system_phenotyp0.76916113
102MP0001545_abnormal_hematopoietic_system0.76916113
103MP0001119_abnormal_female_reproductive0.76652727
104MP0000627_abnormal_mammary_gland0.75879106
105MP0000747_muscle_weakness0.75555543
106MP0003937_abnormal_limbs/digits/tail_de0.74092902
107MP0000733_abnormal_muscle_development0.73653590
108MP0004133_heterotaxia0.72995449
109MP0006036_abnormal_mitochondrial_physio0.72425920
110MP0000703_abnormal_thymus_morphology0.71479472
111MP0000749_muscle_degeneration0.71128799
112MP0001881_abnormal_mammary_gland0.68769629
113MP0003566_abnormal_cell_adhesion0.68355192
114MP0005408_hypopigmentation0.67290745
115MP0000428_abnormal_craniofacial_morphol0.67270602
116MP0003115_abnormal_respiratory_system0.66949897
117MP0001915_intracranial_hemorrhage0.65901098
118MP0003453_abnormal_keratinocyte_physiol0.65884957
119MP0000003_abnormal_adipose_tissue0.65298319
120MP0003943_abnormal_hepatobiliary_system0.63650491
121MP0000858_altered_metastatic_potential0.63260175
122MP0010771_integument_phenotype0.63203434
123MP0002697_abnormal_eye_size0.62118071
124MP0002177_abnormal_outer_ear0.61856593
125MP0003699_abnormal_female_reproductive0.60229991
126MP0000372_irregular_coat_pigmentation0.59228675
127MP0002098_abnormal_vibrissa_morphology0.58912967
128MP0001727_abnormal_embryo_implantation0.58573501
129MP0008770_decreased_survivor_rate0.58415546
130MP0002114_abnormal_axial_skeleton0.55993602
131MP0002722_abnormal_immune_system0.53275455
132MP0004087_abnormal_muscle_fiber0.52814432
133MP0003861_abnormal_nervous_system0.52755312
134MP0000759_abnormal_skeletal_muscle0.52283454
135MP0004145_abnormal_muscle_electrophysio0.52167552
136MP0002106_abnormal_muscle_physiology0.51651345
137MP0000266_abnormal_heart_morphology0.50952671
138MP0005395_other_phenotype0.47902196
139MP0005623_abnormal_meninges_morphology0.47414503
140MP0005377_hearing/vestibular/ear_phenot0.46571637

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.99813021
2Breast hypoplasia (HP:0003187)4.02764783
3Microvesicular hepatic steatosis (HP:0001414)3.82599037
4Ependymoma (HP:0002888)3.80740412
5Abnormality of the anterior horn cell (HP:0006802)3.76889524
6Degeneration of anterior horn cells (HP:0002398)3.76889524
7Selective tooth agenesis (HP:0001592)3.76348136
8Carpal bone hypoplasia (HP:0001498)3.55505105
9Chromsome breakage (HP:0040012)3.47638207
10Cerebral hypomyelination (HP:0006808)3.45237283
11Oral leukoplakia (HP:0002745)3.42280469
12Abnormal gallbladder physiology (HP:0012438)3.39504234
13Cholecystitis (HP:0001082)3.39504234
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.39102289
15Abnormality of the labia minora (HP:0012880)3.28701723
16Patellar aplasia (HP:0006443)3.27058930
17Rough bone trabeculation (HP:0100670)3.11908833
18Aplasia/Hypoplasia of the patella (HP:0006498)3.10342915
19Premature rupture of membranes (HP:0001788)3.07656869
20Meckel diverticulum (HP:0002245)3.04697985
21Impulsivity (HP:0100710)2.99443738
22Medulloblastoma (HP:0002885)2.97661930
23Hyperacusis (HP:0010780)2.97196402
24Colon cancer (HP:0003003)2.96231883
25Abnormality of chromosome stability (HP:0003220)2.94231425
26Insomnia (HP:0100785)2.93715273
27Abnormality of the preputium (HP:0100587)2.93140254
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.91016628
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.88379649
30Abnormality of the ileum (HP:0001549)2.84538948
31Ragged-red muscle fibers (HP:0003200)2.75992019
32Agnosia (HP:0010524)2.67988718
33Entropion (HP:0000621)2.67952232
34Pelvic girdle muscle weakness (HP:0003749)2.65627858
35Absent radius (HP:0003974)2.59183605
36Astrocytoma (HP:0009592)2.58598966
37Abnormality of the astrocytes (HP:0100707)2.58598966
38Shoulder girdle muscle weakness (HP:0003547)2.57910620
39Small intestinal stenosis (HP:0012848)2.56214431
40Duodenal stenosis (HP:0100867)2.56214431
41Abnormalities of placenta or umbilical cord (HP:0001194)2.56184615
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.53607821
43Rhabdomyosarcoma (HP:0002859)2.50395941
44Abnormality of the musculature of the pelvis (HP:0001469)2.50148394
45Abnormality of the hip-girdle musculature (HP:0001445)2.50148394
46Premature ovarian failure (HP:0008209)2.49147096
47Trismus (HP:0000211)2.48972033
48Neoplasm of the pancreas (HP:0002894)2.45531056
49Reduced subcutaneous adipose tissue (HP:0003758)2.44677553
50Abnormality of the fetal cardiovascular system (HP:0010948)2.44091095
51Abnormal umbilical cord blood vessels (HP:0011403)2.44091095
52Single umbilical artery (HP:0001195)2.44091095
53Upper limb muscle weakness (HP:0003484)2.42053613
54Absent thumb (HP:0009777)2.41770782
55Abnormality of the calcaneus (HP:0008364)2.39948374
56Aplasia involving forearm bones (HP:0009822)2.38700694
57Absent forearm bone (HP:0003953)2.38700694
58Glioma (HP:0009733)2.38130967
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.34858578
60Irregular epiphyses (HP:0010582)2.33019579
61Sloping forehead (HP:0000340)2.32937132
62Premature graying of hair (HP:0002216)2.32126391
63Absent epiphyses (HP:0010577)2.29390345
64Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29390345
65Overriding aorta (HP:0002623)2.29177544
66Reticulocytopenia (HP:0001896)2.29011031
67Myelodysplasia (HP:0002863)2.25594998
68Bone marrow hypocellularity (HP:0005528)2.25223937
69Supernumerary spleens (HP:0009799)2.20983861
70Multiple enchondromatosis (HP:0005701)2.20198114
71Basal cell carcinoma (HP:0002671)2.17885636
72Abnormal trabecular bone morphology (HP:0100671)2.17420173
73Cafe-au-lait spot (HP:0000957)2.16376023
74Orthostatic hypotension (HP:0001278)2.15174114
75Abnormal number of incisors (HP:0011064)2.15130591
76Horseshoe kidney (HP:0000085)2.14096063
77Renal duplication (HP:0000075)2.12941898
78Aplasia/hypoplasia of the humerus (HP:0006507)2.11639504
79Secondary amenorrhea (HP:0000869)2.09689063
80Abnormality of cells of the erythroid lineage (HP:0012130)2.09412249
81Increased connective tissue (HP:0009025)2.09175323
82Abnormality of the lower motor neuron (HP:0002366)2.07102022
83Deviation of the thumb (HP:0009603)2.07054976
84Calcaneovalgus deformity (HP:0001848)2.06468179
85Amniotic constriction ring (HP:0009775)2.05123532
86Abnormality of placental membranes (HP:0011409)2.05123532
87Abnormality of the umbilical cord (HP:0010881)2.04499673
88Slender long bone (HP:0003100)2.03843458
89Abnormality of the duodenum (HP:0002246)2.03689761
90Proximal placement of thumb (HP:0009623)2.02999099
91Tracheoesophageal fistula (HP:0002575)2.02962125
92Spinal rigidity (HP:0003306)2.02821925
93Microretrognathia (HP:0000308)2.02632583
94Microglossia (HP:0000171)2.00753355
95Achilles tendon contracture (HP:0001771)2.00438334
96Missing ribs (HP:0000921)2.00304993
97Neoplasm of striated muscle (HP:0009728)1.98559151
98CNS hypomyelination (HP:0003429)1.98471471
99Spinal muscular atrophy (HP:0007269)1.98131649
100Hypokinesia (HP:0002375)1.97921047
101Cellular immunodeficiency (HP:0005374)1.97087444
102Elfin facies (HP:0004428)1.97077761
103Ectopic kidney (HP:0000086)1.97073251
104Squamous cell carcinoma (HP:0002860)1.96638360
105Progressive muscle weakness (HP:0003323)1.96411490
106Ulnar bowing (HP:0003031)1.95394606
107Deformed tarsal bones (HP:0008119)1.92784393
108Abnormality of the carotid arteries (HP:0005344)1.92710130
109Glossoptosis (HP:0000162)1.92432453
110Difficulty climbing stairs (HP:0003551)1.91541756
111Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91376354
112Atresia of the external auditory canal (HP:0000413)1.90510131
113Abnormal number of erythroid precursors (HP:0012131)1.90120860
114Abnormal spermatogenesis (HP:0008669)1.89639259
115Redundant skin (HP:0001582)1.89306495
116Ureteral duplication (HP:0000073)1.88217516
117Elbow flexion contracture (HP:0002987)1.87762322
118Aplastic anemia (HP:0001915)1.87403388
119Abnormal lung lobation (HP:0002101)1.86246634
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.86086609
121Short thumb (HP:0009778)1.85957463
122Adenoma sebaceum (HP:0009720)1.85722758
123Angiofibromas (HP:0010615)1.85722758
124High pitched voice (HP:0001620)1.84126665
125Abnormality of the distal phalanges of the toes (HP:0010182)1.83996236
126Vertebral compression fractures (HP:0002953)1.82314580
127Generalized amyotrophy (HP:0003700)1.82103114
128Cutaneous melanoma (HP:0012056)1.82009757
129Increased nuchal translucency (HP:0010880)1.81427196
130Sparse eyelashes (HP:0000653)1.81285170
131Osteolytic defects of the hand bones (HP:0009699)1.80847065
132Osteolytic defects of the phalanges of the hand (HP:0009771)1.80847065
133Prominent nose (HP:0000448)1.79765058
134Short humerus (HP:0005792)1.79758582
135Postnatal microcephaly (HP:0005484)1.79501144
136Progressive hearing impairment (HP:0001730)1.77574112
137Increased serum lactate (HP:0002151)1.76785341
138Rhabdomyolysis (HP:0003201)1.76572028
139Abnormality of glycolysis (HP:0004366)1.76497545
140Increased serum pyruvate (HP:0003542)1.76497545
141Poikiloderma (HP:0001029)1.75401194
142Cholelithiasis (HP:0001081)1.74033505
143Type I transferrin isoform profile (HP:0003642)1.72228367
144Abnormality of oral frenula (HP:0000190)1.71692740
145Protrusio acetabuli (HP:0003179)1.70938556
146Short clavicles (HP:0000894)1.70741104
147Flat cornea (HP:0007720)1.69441583
148Nemaline bodies (HP:0003798)1.68977933
149Ankle contracture (HP:0006466)1.68288896
150Nonimmune hydrops fetalis (HP:0001790)1.67529443
151Testicular atrophy (HP:0000029)1.67413492
152Sensory axonal neuropathy (HP:0003390)1.65814911
153Ankyloglossia (HP:0010296)1.65520148
154Short nail (HP:0001799)1.65446110
155Progressive external ophthalmoplegia (HP:0000590)1.64674950
156Hypergonadotropic hypogonadism (HP:0000815)1.64464658
157Reduced antithrombin III activity (HP:0001976)1.62862161
158Distal lower limb amyotrophy (HP:0008944)1.62623188
159Abnormality of the tricuspid valve (HP:0001702)1.61569974
160Muscle stiffness (HP:0003552)1.61084175
161Long palpebral fissure (HP:0000637)1.61052341
162Narrow face (HP:0000275)1.60775652
163Natal tooth (HP:0000695)1.59483956
164Limb-girdle muscle atrophy (HP:0003797)1.59418123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.89838740
2WEE13.97338831
3CDC73.94700613
4NEK13.58092621
5EIF2AK13.29060108
6TSSK63.18987189
7NEK22.98427542
8SMG12.97108006
9IRAK32.71371676
10VRK22.44136118
11TTK2.30857026
12PLK42.25378922
13SRPK12.14965638
14PDK32.11717959
15PDK42.11717959
16PLK11.99540985
17MST1R1.92017522
18BRSK21.89834531
19EIF2AK31.84162296
20TESK21.82848843
21PLK31.76911513
22ACVR1B1.70341190
23EPHA21.67578874
24EEF2K1.60159222
25BRSK11.54600538
26ATR1.50283734
27AURKB1.47349529
28CDK121.46259020
29CDK71.43031620
30RPS6KB21.41890097
31TESK11.37088368
32MAP3K81.36535722
33CCNB11.35594079
34AURKA1.34282942
35MKNK11.34229885
36MST41.34158259
37CHEK21.31531267
38PASK1.30387959
39PDK21.28534117
40CHEK11.27830370
41RPS6KA41.26247515
42STK38L1.23301926
43LATS21.21996580
44CDK41.16825284
45SCYL21.15275389
46BRAF1.15140415
47CLK11.14207380
48ERBB41.09765568
49PAK41.05193594
50STK161.03394214
51PKN21.02365825
52ALK1.02056278
53TLK10.99592709
54STK100.98270555
55DYRK30.97952842
56VRK10.95235025
57PIM20.94630664
58MKNK20.93887109
59NME20.93033724
60MAP3K110.85524729
61CDK20.85401605
62MAP2K30.85399022
63ZAK0.84349684
64PNCK0.82473943
65TTN0.82381782
66MAP3K100.82377016
67PAK10.81101105
68MET0.81099150
69TAOK20.80894069
70ICK0.79601445
71TGFBR10.79356559
72AKT30.78082132
73ATM0.75540912
74PRPF4B0.72464587
75ARAF0.68568759
76STK40.66548835
77STK30.65386734
78TRIB30.64368910
79PDGFRA0.64145774
80NUAK10.63432859
81CDK10.62258502
82CSNK2A20.59092523
83MAPK110.58456121
84PIM10.57848136
85PTK20.57685886
86MAP3K30.57453607
87MTOR0.56922309
88TAOK10.54715970
89RAF10.53353823
90CDK80.52391868
91MAPKAPK50.51734191
92CSNK2A10.51708444
93PRKCI0.51535091
94TAF10.51385469
95CSNK1E0.49382630
96MELK0.48939755
97LIMK10.48496547
98CDK90.47833587
99NME10.47406169
100CAMK1D0.47000231
101SIK10.46691272
102KSR20.46484504
103KDR0.43190034
104MAP3K50.41837773
105LRRK20.40963359
106PRKD30.37678456
107MAP3K120.37671229
108FGFR10.37348506
109AKT20.37110083
110MAPKAPK30.36546625
111BRD40.34267231
112NEK60.34162415
113PAK20.32217734
114EIF2AK20.32013388
115CSNK1G30.31912645
116NEK90.31028765
117CDK60.30546315
118PLK20.29999104
119PRKDC0.28964600
120NTRK10.28124044
121DAPK10.27926975
122BCKDK0.27594422
123LATS10.26114210
124ILK0.25975407
125PBK0.24177062

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69889266
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.28332519
3Mismatch repair_Homo sapiens_hsa034304.00688226
4RNA transport_Homo sapiens_hsa030133.66800219
5Proteasome_Homo sapiens_hsa030503.56804752
6RNA polymerase_Homo sapiens_hsa030203.28027205
7Spliceosome_Homo sapiens_hsa030403.21184953
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.12654404
9Cell cycle_Homo sapiens_hsa041102.95286955
10Base excision repair_Homo sapiens_hsa034102.85974343
11Nucleotide excision repair_Homo sapiens_hsa034202.73886861
12One carbon pool by folate_Homo sapiens_hsa006702.73216652
13Homologous recombination_Homo sapiens_hsa034402.50004859
14Pyrimidine metabolism_Homo sapiens_hsa002402.29296068
15Ribosome_Homo sapiens_hsa030102.14979689
16Fanconi anemia pathway_Homo sapiens_hsa034602.11160032
17mRNA surveillance pathway_Homo sapiens_hsa030151.99444643
18Basal transcription factors_Homo sapiens_hsa030221.98219679
19RNA degradation_Homo sapiens_hsa030181.89518394
20Non-homologous end-joining_Homo sapiens_hsa034501.70681065
21Vitamin B6 metabolism_Homo sapiens_hsa007501.64593698
22p53 signaling pathway_Homo sapiens_hsa041151.60129612
23Biosynthesis of amino acids_Homo sapiens_hsa012301.60052607
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48483553
25Oocyte meiosis_Homo sapiens_hsa041141.46390619
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35240270
27Purine metabolism_Homo sapiens_hsa002301.34384033
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.33444552
29Epstein-Barr virus infection_Homo sapiens_hsa051691.30210160
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18215671
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.17459495
32Pentose phosphate pathway_Homo sapiens_hsa000301.17091225
33Carbon metabolism_Homo sapiens_hsa012001.14409992
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.03096671
35Viral carcinogenesis_Homo sapiens_hsa052030.99288386
36Systemic lupus erythematosus_Homo sapiens_hsa053220.99163798
37Cyanoamino acid metabolism_Homo sapiens_hsa004600.97942846
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97885446
39Selenocompound metabolism_Homo sapiens_hsa004500.82054347
40Fatty acid elongation_Homo sapiens_hsa000620.77913894
41Protein export_Homo sapiens_hsa030600.77234847
42Antigen processing and presentation_Homo sapiens_hsa046120.76979327
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75437146
44HTLV-I infection_Homo sapiens_hsa051660.72168628
45Fructose and mannose metabolism_Homo sapiens_hsa000510.70204431
46Thyroid cancer_Homo sapiens_hsa052160.68193758
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63287637
48Herpes simplex infection_Homo sapiens_hsa051680.60118001
49Drug metabolism - other enzymes_Homo sapiens_hsa009830.58284752
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57869423
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.56945151
52MicroRNAs in cancer_Homo sapiens_hsa052060.55695091
53mTOR signaling pathway_Homo sapiens_hsa041500.55138953
54Legionellosis_Homo sapiens_hsa051340.53073128
55Arginine and proline metabolism_Homo sapiens_hsa003300.53065363
56Steroid biosynthesis_Homo sapiens_hsa001000.52624884
57Hippo signaling pathway_Homo sapiens_hsa043900.51671400
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51220173
59Pyruvate metabolism_Homo sapiens_hsa006200.51047039
60Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51039651
61Sulfur metabolism_Homo sapiens_hsa009200.50352063
62Lysine degradation_Homo sapiens_hsa003100.50345146
63HIF-1 signaling pathway_Homo sapiens_hsa040660.49256097
64Vibrio cholerae infection_Homo sapiens_hsa051100.48567502
65Small cell lung cancer_Homo sapiens_hsa052220.45286148
66Huntingtons disease_Homo sapiens_hsa050160.45181837
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44661302
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43886463
69Sulfur relay system_Homo sapiens_hsa041220.42769794
70Pancreatic cancer_Homo sapiens_hsa052120.41588022
71Folate biosynthesis_Homo sapiens_hsa007900.41508140
72TGF-beta signaling pathway_Homo sapiens_hsa043500.39709064
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36947134
74Alcoholism_Homo sapiens_hsa050340.36756360
75Colorectal cancer_Homo sapiens_hsa052100.36352590
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.36142887
77Proteoglycans in cancer_Homo sapiens_hsa052050.35922812
78Bladder cancer_Homo sapiens_hsa052190.34452366
79Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34141310
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33198749
81Apoptosis_Homo sapiens_hsa042100.31946136
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31466735
83Glutathione metabolism_Homo sapiens_hsa004800.30037351
84Basal cell carcinoma_Homo sapiens_hsa052170.29313434
85Fatty acid biosynthesis_Homo sapiens_hsa000610.28437234
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.28325479
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28247349
88Galactose metabolism_Homo sapiens_hsa000520.28138004
89Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26789929
90Arginine biosynthesis_Homo sapiens_hsa002200.25272083
91Tight junction_Homo sapiens_hsa045300.24446461
92Propanoate metabolism_Homo sapiens_hsa006400.23699863
93Focal adhesion_Homo sapiens_hsa045100.21700698
94Glucagon signaling pathway_Homo sapiens_hsa049220.20515191
95Hedgehog signaling pathway_Homo sapiens_hsa043400.20305827
96Oxidative phosphorylation_Homo sapiens_hsa001900.19829613
97Glioma_Homo sapiens_hsa052140.19786835
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19662970
99Chronic myeloid leukemia_Homo sapiens_hsa052200.19525153
100Shigellosis_Homo sapiens_hsa051310.18680460
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17967852
102Fatty acid metabolism_Homo sapiens_hsa012120.17371410
103Alzheimers disease_Homo sapiens_hsa050100.16987759
104Hepatitis B_Homo sapiens_hsa051610.16849208
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.16132256
106Adherens junction_Homo sapiens_hsa045200.15949458
107Viral myocarditis_Homo sapiens_hsa054160.13145113
108Metabolic pathways_Homo sapiens_hsa011000.12827577
109N-Glycan biosynthesis_Homo sapiens_hsa005100.12099840
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10735931
111Notch signaling pathway_Homo sapiens_hsa043300.10673650
112Pathways in cancer_Homo sapiens_hsa052000.10520007
113Parkinsons disease_Homo sapiens_hsa050120.08469626
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08146477
115Regulation of autophagy_Homo sapiens_hsa041400.07855420
116Non-small cell lung cancer_Homo sapiens_hsa052230.07797466
117Influenza A_Homo sapiens_hsa051640.07508728
118AMPK signaling pathway_Homo sapiens_hsa041520.07205062
119Prostate cancer_Homo sapiens_hsa052150.06637561
120FoxO signaling pathway_Homo sapiens_hsa040680.06440593
121Melanoma_Homo sapiens_hsa052180.06226854
122Renin-angiotensin system_Homo sapiens_hsa046140.05718766
123Acute myeloid leukemia_Homo sapiens_hsa052210.04949913

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