ABCF3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NADH metabolic process (GO:0006734)4.62046506
2protein localization to endosome (GO:0036010)4.60409619
3tricarboxylic acid cycle (GO:0006099)4.27288564
4succinate metabolic process (GO:0006105)4.15059948
5L-phenylalanine catabolic process (GO:0006559)4.08607278
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.08607278
7oxaloacetate metabolic process (GO:0006107)4.01527478
8lysine metabolic process (GO:0006553)3.94665490
9lysine catabolic process (GO:0006554)3.94665490
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.83814562
11L-phenylalanine metabolic process (GO:0006558)3.83814562
12aspartate family amino acid catabolic process (GO:0009068)3.81241105
13negative regulation of erythrocyte differentiation (GO:0045647)3.79126581
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.72387672
15negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.68548834
16barbed-end actin filament capping (GO:0051016)3.48388511
17chaperone-mediated protein transport (GO:0072321)3.34243219
18negative regulation of cell size (GO:0045792)3.28824117
19energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.28670753
20ATP hydrolysis coupled proton transport (GO:0015991)3.28670753
21synaptic vesicle exocytosis (GO:0016079)3.28448708
22peroxisome fission (GO:0016559)3.28158725
23coenzyme catabolic process (GO:0009109)3.27786066
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24876084
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.23643676
26glutamate secretion (GO:0014047)3.21036049
27positive regulation of mitochondrial fission (GO:0090141)3.18894946
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.14748447
29positive regulation of gamma-delta T cell activation (GO:0046645)3.12542356
30piRNA metabolic process (GO:0034587)3.11475832
31cellular ketone body metabolic process (GO:0046950)3.10453579
32regulation of defense response to virus by virus (GO:0050690)3.09733269
33multicellular organism reproduction (GO:0032504)3.04717788
34mannose metabolic process (GO:0006013)3.03559957
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03140003
36pinocytosis (GO:0006907)3.01398895
37epithelial cell differentiation involved in prostate gland development (GO:0060742)3.00514534
38synaptic vesicle docking involved in exocytosis (GO:0016081)3.00371587
39endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.00346167
40protein retention in ER lumen (GO:0006621)2.96176601
41proline biosynthetic process (GO:0006561)2.95300981
42binding of sperm to zona pellucida (GO:0007339)2.95132275
43protein deneddylation (GO:0000338)2.93320914
44aromatic amino acid family catabolic process (GO:0009074)2.93188758
45pentose-phosphate shunt (GO:0006098)2.91825790
46neurotransmitter secretion (GO:0007269)2.89091710
47focal adhesion assembly (GO:0048041)2.88376401
48cell-substrate adherens junction assembly (GO:0007045)2.88376401
49gluconeogenesis (GO:0006094)2.86765907
50Golgi transport vesicle coating (GO:0048200)2.85873446
51COPI coating of Golgi vesicle (GO:0048205)2.85873446
52positive regulation of Cdc42 GTPase activity (GO:0043089)2.84834937
53NIK/NF-kappaB signaling (GO:0038061)2.84126058
54regulation of acyl-CoA biosynthetic process (GO:0050812)2.83717064
55dicarboxylic acid catabolic process (GO:0043649)2.83603592
56cullin deneddylation (GO:0010388)2.82479384
57adherens junction assembly (GO:0034333)2.82422464
58regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.81838668
59regulation of synaptic vesicle exocytosis (GO:2000300)2.81307878
60regulation of synaptic vesicle transport (GO:1902803)2.79183171
61activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.78130938
62basement membrane organization (GO:0071711)2.77556382
63bile acid biosynthetic process (GO:0006699)2.75777918
64positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.75666313
65hexose biosynthetic process (GO:0019319)2.74565336
66activation of Rac GTPase activity (GO:0032863)2.73702176
67alpha-amino acid catabolic process (GO:1901606)2.73405105
68branched-chain amino acid catabolic process (GO:0009083)2.72488719
69lactate metabolic process (GO:0006089)2.71852794
70glycosphingolipid catabolic process (GO:0046479)2.71006042
71transferrin transport (GO:0033572)2.69962108
72cytoskeletal anchoring at plasma membrane (GO:0007016)2.69178234
73regulation of type I interferon-mediated signaling pathway (GO:0060338)2.68003241
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.67877211
75response to laminar fluid shear stress (GO:0034616)2.67334959
76positive regulation of nuclease activity (GO:0032075)2.65776177
77sperm-egg recognition (GO:0035036)2.64876860
78protein maturation by protein folding (GO:0022417)2.64614409
79skin morphogenesis (GO:0043589)2.64300079
80ketone body metabolic process (GO:1902224)2.62285563
81stress fiber assembly (GO:0043149)2.62077319
82mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.60908617
83cellular amino acid catabolic process (GO:0009063)2.58606329
84maternal placenta development (GO:0001893)2.58562064
85trivalent inorganic cation transport (GO:0072512)2.57610616
86ferric iron transport (GO:0015682)2.57610616
87urea metabolic process (GO:0019627)2.57201017
88urea cycle (GO:0000050)2.57201017
89regulation of coenzyme metabolic process (GO:0051196)2.56803437
90regulation of cofactor metabolic process (GO:0051193)2.56803437
91spliceosomal tri-snRNP complex assembly (GO:0000244)2.56300440
922-oxoglutarate metabolic process (GO:0006103)2.55842748
93positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55692935
94vesicle coating (GO:0006901)2.55031319
95NAD metabolic process (GO:0019674)2.54967514
96triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.54084239
97cofactor catabolic process (GO:0051187)2.53796839
98endoplasmic reticulum unfolded protein response (GO:0030968)2.53728661
99reproduction (GO:0000003)2.53200717
100glucose catabolic process (GO:0006007)2.53155985
101acyl-CoA biosynthetic process (GO:0071616)2.53033491
102thioester biosynthetic process (GO:0035384)2.53033491
103fructose metabolic process (GO:0006000)2.52649827
104positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.52542752
105tyrosine metabolic process (GO:0006570)2.52318269
106regulation of oxidative phosphorylation (GO:0002082)2.52249837
107antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51041487
108response to insecticide (GO:0017085)2.50222450
109embryonic process involved in female pregnancy (GO:0060136)2.49850693
110germinal center formation (GO:0002467)2.49712164
111dicarboxylic acid biosynthetic process (GO:0043650)2.48141316
112tricarboxylic acid metabolic process (GO:0072350)2.47903808
113cysteine metabolic process (GO:0006534)2.47726698
114NADPH regeneration (GO:0006740)2.47532898
115fatty acid elongation (GO:0030497)2.47277117
116glutamate metabolic process (GO:0006536)2.47132462
117monosaccharide biosynthetic process (GO:0046364)2.46134199
118amino sugar catabolic process (GO:0046348)2.45098763
119amino acid salvage (GO:0043102)2.44586276
120L-methionine salvage (GO:0071267)2.44586276
121L-methionine biosynthetic process (GO:0071265)2.44586276
122regulation of glucose import in response to insulin stimulus (GO:2001273)2.44526358
123apoptotic process involved in morphogenesis (GO:0060561)2.43526756
124aromatic amino acid family metabolic process (GO:0009072)2.43118903
125glucose 6-phosphate metabolic process (GO:0051156)2.43065124
126ER-nucleus signaling pathway (GO:0006984)2.41629097
127cell-substrate junction assembly (GO:0007044)2.40943470
128regulation of nuclease activity (GO:0032069)2.40719904
129response to manganese ion (GO:0010042)2.40378181
130membrane protein ectodomain proteolysis (GO:0006509)2.39926705
131synaptic vesicle endocytosis (GO:0048488)2.39881171
132regulation of cholesterol homeostasis (GO:2000188)2.39862082
133antigen processing and presentation of endogenous antigen (GO:0019883)2.39570679
134glycolipid catabolic process (GO:0019377)2.39475664
135sulfur amino acid catabolic process (GO:0000098)2.39049374
136acetyl-CoA metabolic process (GO:0006084)2.38932437
137cell-cell recognition (GO:0009988)2.38384614
138fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.38250174
139modulation by symbiont of host cellular process (GO:0044068)2.38078574
140amino-acid betaine metabolic process (GO:0006577)2.37773323
141antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.36800007
142synaptic vesicle maturation (GO:0016188)2.36433279
143heme transport (GO:0015886)2.35989088
144cellular response to unfolded protein (GO:0034620)2.35844667
145regulation of acrosome reaction (GO:0060046)2.35667735
146regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35340872
147negative regulation of viral release from host cell (GO:1902187)2.34714037
148regulation of gamma-delta T cell differentiation (GO:0045586)2.34632173
149glyoxylate metabolic process (GO:0046487)2.34489170
150alpha-linolenic acid metabolic process (GO:0036109)2.33910286
151nitrogen cycle metabolic process (GO:0071941)2.33884838
152response to water (GO:0009415)2.33872776
153regulation of neurotransmitter levels (GO:0001505)2.33782175
154neurotransmitter transport (GO:0006836)2.33710843
155regulation of early endosome to late endosome transport (GO:2000641)2.33710070
156proline transport (GO:0015824)2.32844736
157lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31883209
158aspartate family amino acid metabolic process (GO:0009066)2.31826787
159mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31809525
160regulation of gamma-delta T cell activation (GO:0046643)2.31603038
161negative regulation of fibrinolysis (GO:0051918)2.31351854
162regulation of leukocyte degranulation (GO:0043300)2.31123744
163positive regulation of protein dephosphorylation (GO:0035307)2.31032072
164regulation of mitochondrial fission (GO:0090140)2.30249912
165positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.30142366
166mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.30033058
167gamma-aminobutyric acid transport (GO:0015812)2.30020028
168fatty-acyl-CoA metabolic process (GO:0035337)2.29292197
169bile acid metabolic process (GO:0008206)2.28918116
170actin filament depolymerization (GO:0030042)2.28821498
171negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.28695836
172negative regulation of cell killing (GO:0031342)2.28695836
173acyl-CoA metabolic process (GO:0006637)2.28600258
174thioester metabolic process (GO:0035383)2.28600258
175regulation of membrane protein ectodomain proteolysis (GO:0051043)2.27223681
176regulation of histone H3-K27 methylation (GO:0061085)2.26028805
177COPII vesicle coating (GO:0048208)2.25423616
178regulation of necrotic cell death (GO:0010939)2.25346989
179regulation of superoxide anion generation (GO:0032928)2.25279465
180desmosome organization (GO:0002934)2.24624471
181regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.24325753
1823-UTR-mediated mRNA stabilization (GO:0070935)2.20866960
183response to peptidoglycan (GO:0032494)2.20370284
184negative regulation of protein localization to plasma membrane (GO:1903077)2.19111625
185embryo implantation (GO:0007566)2.18796295
186nuclear envelope reassembly (GO:0031468)2.16667605
187mitotic nuclear envelope reassembly (GO:0007084)2.16667605
188regulation of extracellular matrix disassembly (GO:0010715)2.15098200
189negative regulation of necroptotic process (GO:0060546)2.14917680
190positive regulation of extracellular matrix organization (GO:1903055)2.14347228
191cellular response to interleukin-4 (GO:0071353)2.14345199
192amyloid precursor protein catabolic process (GO:0042987)2.13942628
193negative regulation of skeletal muscle tissue development (GO:0048642)2.13851671
194thymic T cell selection (GO:0045061)2.13773017
195cellular response to topologically incorrect protein (GO:0035967)2.13630939
196tolerance induction (GO:0002507)2.12951168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.62834561
2ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.00140360
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.92306030
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.90451329
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.87061703
6EZH2_22144423_ChIP-Seq_EOC_Human2.73331576
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.57034413
8GBX2_23144817_ChIP-Seq_PC3_Human2.56718552
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50898798
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.50147127
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.49393358
12MYC_22102868_ChIP-Seq_BL_Human2.49060205
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.46495373
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.43167697
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.41776254
16VDR_21846776_ChIP-Seq_THP-1_Human2.37598358
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.35544192
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.35381990
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.32081024
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.30264552
21TAF15_26573619_Chip-Seq_HEK293_Human2.28913834
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28183908
23* LXR_22292898_ChIP-Seq_THP-1_Human2.26259630
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25012473
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.15845559
26RARG_19884340_ChIP-ChIP_MEFs_Mouse2.14595464
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.14134756
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.11435743
29RACK7_27058665_Chip-Seq_MCF-7_Human2.10235822
30PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.08219391
31REST_21632747_ChIP-Seq_MESCs_Mouse2.05618665
32PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03816246
33* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02982763
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95734652
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.95205531
36FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.91635580
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.87533099
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.83355958
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80084654
40TCF7_22412390_ChIP-Seq_EML_Mouse1.79502104
41RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77595922
42CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.75938887
43MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74956622
44HTT_18923047_ChIP-ChIP_STHdh_Human1.71157898
45KDM2B_26808549_Chip-Seq_DND41_Human1.69941840
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.67605710
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.66781357
48CLOCK_20551151_ChIP-Seq_293T_Human1.63881485
49SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.62243601
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.60326079
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.56119581
52ETS1_20019798_ChIP-Seq_JURKAT_Human1.55941189
53* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53950824
54MAF_26560356_Chip-Seq_TH1_Human1.50550179
55TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49866337
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.49019889
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48968044
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.47542684
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.46950499
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46462597
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44775817
62KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43696770
63ZNF274_21170338_ChIP-Seq_K562_Hela1.43291753
64* SRF_21415370_ChIP-Seq_HL-1_Mouse1.42991556
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42157372
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40338298
67GABP_17652178_ChIP-ChIP_JURKAT_Human1.40201782
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40080293
69MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39222414
70VDR_24763502_ChIP-Seq_THP-1_Human1.38008511
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36995493
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35739725
73CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35343098
74UTX_26944678_Chip-Seq_JUKART_Human1.34632692
75NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34119652
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33898453
77CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31983477
78* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30977468
79TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30665852
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30458296
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30409295
82KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.29436047
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29150539
84MAF_26560356_Chip-Seq_TH2_Human1.28766295
85* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27741473
86IRF8_22096565_ChIP-ChIP_GC-B_Human1.27570920
87ATF3_27146783_Chip-Seq_COLON_Human1.27270787
88RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.27143440
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27123052
90P68_20966046_ChIP-Seq_HELA_Human1.27114610
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26917577
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.26643842
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.26283604
94PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25261845
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.25140265
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24332830
97SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23849940
98STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23511463
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.23140248
100TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.22454533
101EST1_17652178_ChIP-ChIP_JURKAT_Human1.20890032
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.19406823
103STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18321771
104ELF1_20517297_ChIP-Seq_JURKAT_Human1.17892625
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17624229
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.17238982
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.17231757
108* GABP_19822575_ChIP-Seq_HepG2_Human1.16670879
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16070931
110SMC4_20622854_ChIP-Seq_HELA_Human1.15352651
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.15315090
112TFEB_21752829_ChIP-Seq_HELA_Human1.14925576
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14909829
114ESR1_21235772_ChIP-Seq_MCF-7_Human1.14442933
115NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14319956
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13904868
117EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11445708
118NCOR1_26117541_ChIP-Seq_K562_Human1.10228920
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10100450
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.09726778
121KDM2B_26808549_Chip-Seq_K562_Human1.09681026
122SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.08576113
123TET1_21490601_ChIP-Seq_MESCs_Mouse1.08294279
124REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07775056
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07724451
126SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07433846
127EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05938646
128SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05847755
129PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05726233
130SPI1_23127762_ChIP-Seq_K562_Human1.05365807
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04263061
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04164066
133CREB1_26743006_Chip-Seq_LNCaP_Human1.03986983
134HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03913644
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03913024
136CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03648073
137BCOR_27268052_Chip-Seq_Bcells_Human1.03501450
138STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02451455
139DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02435936
140KDM2B_26808549_Chip-Seq_JURKAT_Human1.02251314
141TP53_22573176_ChIP-Seq_HFKS_Human1.02147358
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01642920
143YY1_21170310_ChIP-Seq_MESCs_Mouse1.01571592
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01563976
145POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01124073
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98251536
147* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98052050
148NCOR_22424771_ChIP-Seq_293T_Human0.96370930
149SOX2_21211035_ChIP-Seq_LN229_Gbm0.93711724
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93682781
151* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93078315
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.91053661
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90749876
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89579404
155PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88306073
156SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.85845842
157ZNF263_19887448_ChIP-Seq_K562_Human0.84632485
158FOXH1_21741376_ChIP-Seq_ESCs_Human0.84044477
159ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.83423118
160NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.82694682
161ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.82123317
162RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81691151
163CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81589886
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81191985
165ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81134722
166ERA_21632823_ChIP-Seq_H3396_Human0.80793601
167OCT4_20526341_ChIP-Seq_ESCs_Human0.80593735
168DNAJC2_21179169_ChIP-ChIP_NT2_Human0.79523492
169PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78765534
170MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.78091677
171TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.77302659
172SOX2_21211035_ChIP-Seq_LN229_Human0.76670737
173BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76298729
174SMAD4_21799915_ChIP-Seq_A2780_Human0.75012666
175KLF4_19829295_ChIP-Seq_ESCs_Human0.74350566
176ER_23166858_ChIP-Seq_MCF-7_Human0.74119313
177GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73863874
178EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.73690307
179IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.73604805
180CBP_20019798_ChIP-Seq_JUKART_Human0.73604805
181SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.73355386
182E2F1_17053090_ChIP-ChIP_MCF-7_Human0.72544632
183GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72449156
184AUTS2_25519132_ChIP-Seq_293T-REX_Human0.72178159
185TET1_21451524_ChIP-Seq_MESCs_Mouse0.71981087
186CTCF_20526341_ChIP-Seq_ESCs_Human0.71975461
187TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.71456900
188YY1_22570637_ChIP-Seq_MALME-3M_Human0.70860875

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.41186955
2MP0005058_abnormal_lysosome_morphology3.61770289
3MP0003705_abnormal_hypodermis_morpholog3.40189632
4MP0005365_abnormal_bile_salt3.27903711
5MP0002837_dystrophic_cardiac_calcinosis3.21532571
6MP0005360_urolithiasis2.97234505
7MP0010234_abnormal_vibrissa_follicle2.91483059
8MP0003172_abnormal_lysosome_physiology2.75744886
9MP0004859_abnormal_synaptic_plasticity2.74187113
10MP0003880_abnormal_central_pattern2.72526509
11MP0003191_abnormal_cellular_cholesterol2.69501533
12MP0005085_abnormal_gallbladder_physiolo2.62357018
13MP0003806_abnormal_nucleotide_metabolis2.54493404
14MP0008875_abnormal_xenobiotic_pharmacok2.39246337
15MP0003436_decreased_susceptibility_to2.35692520
16MP0002736_abnormal_nociception_after2.27711632
17MP0005083_abnormal_biliary_tract2.22663349
18MP0003646_muscle_fatigue2.14837305
19MP0002909_abnormal_adrenal_gland2.14707577
20MP0002877_abnormal_melanocyte_morpholog2.14612015
21MP0001968_abnormal_touch/_nociception2.12124603
22MP0003303_peritoneal_inflammation2.09132148
23MP0009046_muscle_twitch2.06335009
24MP0003566_abnormal_cell_adhesion2.05342663
25MP0003195_calcinosis2.02318139
26MP0006036_abnormal_mitochondrial_physio2.02067436
27MP0003635_abnormal_synaptic_transmissio2.01895882
28MP0002064_seizures2.00879958
29MP0005646_abnormal_pituitary_gland1.96435237
30MP0003300_gastrointestinal_ulcer1.92364643
31MP0002822_catalepsy1.91308786
32MP0006035_abnormal_mitochondrial_morpho1.90045794
33MP0009745_abnormal_behavioral_response1.89918250
34MP0001529_abnormal_vocalization1.88807519
35MP0001905_abnormal_dopamine_level1.86131886
36MP0003329_amyloid_beta_deposits1.83652996
37MP0004036_abnormal_muscle_relaxation1.81635691
38MP0000013_abnormal_adipose_tissue1.80536920
39MP0004270_analgesia1.78513136
40MP0006276_abnormal_autonomic_nervous1.75573809
41MP0002272_abnormal_nervous_system1.73533846
42MP0003453_abnormal_keratinocyte_physiol1.73219911
43MP0010329_abnormal_lipoprotein_level1.69061593
44MP0005332_abnormal_amino_acid1.65494301
45MP0001849_ear_inflammation1.65484909
46MP0004043_abnormal_pH_regulation1.64520542
47MP0008438_abnormal_cutaneous_collagen1.64493911
48MP0002796_impaired_skin_barrier1.64468502
49MP0000751_myopathy1.63902263
50MP0002063_abnormal_learning/memory/cond1.63597204
51MP0005410_abnormal_fertilization1.60674118
52MP0004185_abnormal_adipocyte_glucose1.59987543
53MP0002734_abnormal_mechanical_nocicepti1.59323433
54MP0004947_skin_inflammation1.58624742
55MP0002572_abnormal_emotion/affect_behav1.58498489
56MP0002876_abnormal_thyroid_physiology1.53642150
57MP0003763_abnormal_thymus_physiology1.51158126
58MP0003075_altered_response_to1.50603281
59MP0009333_abnormal_splenocyte_physiolog1.49753139
60MP0005076_abnormal_cell_differentiation1.47125176
61MP0001666_abnormal_nutrient_absorption1.46992983
62MP0000858_altered_metastatic_potential1.44628789
63MP0004142_abnormal_muscle_tone1.44558034
64MP0009840_abnormal_foam_cell1.44277735
65MP0004924_abnormal_behavior1.42306382
66MP0005386_behavior/neurological_phenoty1.42306382
67MP0004145_abnormal_muscle_electrophysio1.41440505
68MP0003879_abnormal_hair_cell1.40872445
69MP0002269_muscular_atrophy1.40496769
70MP0002735_abnormal_chemical_nociception1.38150643
71MP0001853_heart_inflammation1.38038650
72MP0008877_abnormal_DNA_methylation1.35508849
73MP0004510_myositis1.32981317
74MP0003718_maternal_effect1.32294469
75MP0000749_muscle_degeneration1.31870990
76MP0003091_abnormal_cell_migration1.31490861
77MP0001440_abnormal_grooming_behavior1.29411376
78MP0009278_abnormal_bone_marrow1.29058296
79MP0000604_amyloidosis1.28879335
80MP0003656_abnormal_erythrocyte_physiolo1.27552917
81MP0001533_abnormal_skeleton_physiology1.27190078
82MP0004264_abnormal_extraembryonic_tissu1.26367280
83MP0000747_muscle_weakness1.26174148
84MP0009780_abnormal_chondrocyte_physiolo1.25792168
85MP0002419_abnormal_innate_immunity1.25515000
86MP0000750_abnormal_muscle_regeneration1.24838447
87MP0002067_abnormal_sensory_capabilities1.24562557
88MP0005000_abnormal_immune_tolerance1.22427316
89MP0000733_abnormal_muscle_development1.21724860
90MP0005025_abnormal_response_to1.21624084
91MP0002118_abnormal_lipid_homeostasis1.21597072
92MP0005257_abnormal_intraocular_pressure1.21518365
93MP0005330_cardiomyopathy1.19448396
94MP0004084_abnormal_cardiac_muscle1.19393687
95MP0002060_abnormal_skin_morphology1.19151491
96MP0001764_abnormal_homeostasis1.18253266
97MP0002148_abnormal_hypersensitivity_rea1.17912380
98MP0004087_abnormal_muscle_fiber1.16578243
99MP0002254_reproductive_system_inflammat1.16496806
100MP0000759_abnormal_skeletal_muscle1.16141779
101MP0008260_abnormal_autophagy1.16132814
102MP0005535_abnormal_body_temperature1.15109890
103MP0008872_abnormal_physiological_respon1.14182448
104MP0005501_abnormal_skin_physiology1.13129358
105MP0002078_abnormal_glucose_homeostasis1.12360535
106MP0005451_abnormal_body_composition1.11853758
107MP0009697_abnormal_copulation1.11665424
108MP0004130_abnormal_muscle_cell1.09273999
109MP0004858_abnormal_nervous_system1.09197995
110MP0004233_abnormal_muscle_weight1.08397208
111MP0005464_abnormal_platelet_physiology1.08283129
112MP0005319_abnormal_enzyme/_coenzyme1.07034827
113MP0003279_aneurysm1.06512179
114MP0004811_abnormal_neuron_physiology1.03432036
115MP0005165_increased_susceptibility_to1.03182271
116MP0001835_abnormal_antigen_presentation1.02881274
117MP0000003_abnormal_adipose_tissue1.02869947
118MP0002733_abnormal_thermal_nociception1.01780930
119MP0002452_abnormal_antigen_presenting1.01349915
120MP0002396_abnormal_hematopoietic_system1.01092102
121MP0002229_neurodegeneration1.00996621
122MP0004215_abnormal_myocardial_fiber1.00703442
123MP0001970_abnormal_pain_threshold1.00665741
124MP0010155_abnormal_intestine_physiology1.00356923
125MP0002723_abnormal_immune_serum0.98170275
126MP0001790_abnormal_immune_system0.98132959
127MP0005387_immune_system_phenotype0.98132959
128MP0010352_gastrointestinal_tract_polyps0.98089256
129MP0005023_abnormal_wound_healing0.97174392
130MP0002653_abnormal_ependyma_morphology0.95813826
131MP0010386_abnormal_urinary_bladder0.95753683
132MP0001216_abnormal_epidermal_layer0.95519358
133MP0005584_abnormal_enzyme/coenzyme_acti0.95033979
134MP0001501_abnormal_sleep_pattern0.94537806
135MP0003868_abnormal_feces_composition0.94321811
136MP0003828_pulmonary_edema0.94087540
137MP0006138_congestive_heart_failure0.93511768
138MP0001929_abnormal_gametogenesis0.93255352
139MP0000685_abnormal_immune_system0.93020718
140MP0001819_abnormal_immune_cell0.92472349
141MP0005266_abnormal_metabolism0.92294304
142MP0005621_abnormal_cell_physiology0.92050529
143MP0005670_abnormal_white_adipose0.91945826
144MP0005375_adipose_tissue_phenotype0.91799659
145MP0005666_abnormal_adipose_tissue0.91511240
146MP0005166_decreased_susceptibility_to0.91440764
147MP0002420_abnormal_adaptive_immunity0.91378809
148MP0003633_abnormal_nervous_system0.90469005
149MP0002066_abnormal_motor_capabilities/c0.90412287
150MP0002998_abnormal_bone_remodeling0.90340360
151MP0003183_abnormal_peptide_metabolism0.89214137
152MP0003122_maternal_imprinting0.87614090
153MP0001800_abnormal_humoral_immune0.87237513
154MP0000609_abnormal_liver_physiology0.86991529
155MP0003448_altered_tumor_morphology0.86801668
156MP0009785_altered_susceptibility_to0.86570199
157MP0005636_abnormal_mineral_homeostasis0.86134473
158MP0008469_abnormal_protein_level0.84129042
159MP0008569_lethality_at_weaning0.83764318
160MP0006082_CNS_inflammation0.83679202
161MP0001881_abnormal_mammary_gland0.83635977
162MP0003698_abnormal_male_reproductive0.83342860
163MP0002332_abnormal_exercise_endurance0.81053005
164MP0003631_nervous_system_phenotype0.80857583
165MP0004147_increased_porphyrin_level0.79959397
166MP0010630_abnormal_cardiac_muscle0.79557757
167MP0002398_abnormal_bone_marrow0.79463239
168MP0002089_abnormal_postnatal_growth/wei0.78442794
169MP0002896_abnormal_bone_mineralization0.78194839
170MP0001845_abnormal_inflammatory_respons0.77991711
171MP0001661_extended_life_span0.77319410
172MP0002166_altered_tumor_susceptibility0.76840429
173MP0001756_abnormal_urination0.76500693
174MP0003953_abnormal_hormone_level0.74995216
175MP0001243_abnormal_dermal_layer0.74751332
176MP0001730_embryonic_growth_arrest0.74470970
177MP0004085_abnormal_heartbeat0.74423897
178MP0001958_emphysema0.73736938
179MP0009931_abnormal_skin_appearance0.73724852
180MP0000343_altered_response_to0.73365380
181MP0008874_decreased_physiological_sensi0.73332002
182MP0001486_abnormal_startle_reflex0.73327948

Predicted human phenotypes

RankGene SetZ-score
1Pheochromocytoma (HP:0002666)3.76843936
2Abnormality of glycolysis (HP:0004366)3.71517419
3Increased serum pyruvate (HP:0003542)3.71517419
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.52556206
5Acute encephalopathy (HP:0006846)3.40610491
6Neuroendocrine neoplasm (HP:0100634)3.33611678
7Abnormal mitochondria in muscle tissue (HP:0008316)3.32727627
8Acute necrotizing encephalopathy (HP:0006965)3.27617383
9Vertebral compression fractures (HP:0002953)3.16266882
10Hepatocellular necrosis (HP:0001404)3.16065745
11Increased connective tissue (HP:0009025)3.11824548
12Abnormality of liposaccharide metabolism (HP:0010968)3.11400106
13Abnormality of glycosphingolipid metabolism (HP:0004343)3.11400106
14Abnormality of glycolipid metabolism (HP:0010969)3.11400106
15Distal lower limb muscle weakness (HP:0009053)3.09939318
16Centrally nucleated skeletal muscle fibers (HP:0003687)3.08314557
17Gout (HP:0001997)3.06109438
18Hypobetalipoproteinemia (HP:0003563)3.05373489
19Atonic seizures (HP:0010819)3.04871001
20Progressive macrocephaly (HP:0004481)3.04525629
21Focal motor seizures (HP:0011153)3.02939404
22Deep venous thrombosis (HP:0002625)3.02382646
23Cholecystitis (HP:0001082)3.00391344
24Abnormal gallbladder physiology (HP:0012438)3.00391344
25Hepatic necrosis (HP:0002605)2.98452036
26Cerebral edema (HP:0002181)2.93468590
27Dysostosis multiplex (HP:0000943)2.90697478
28Hyperventilation (HP:0002883)2.90320590
29Ketosis (HP:0001946)2.86976551
30Mitochondrial inheritance (HP:0001427)2.84737097
31Hyperglycinemia (HP:0002154)2.84277822
32Increased CSF lactate (HP:0002490)2.78163219
33Hyperacusis (HP:0010780)2.66940354
34Premature rupture of membranes (HP:0001788)2.65271221
35Intrahepatic cholestasis (HP:0001406)2.65264679
36Eczematoid dermatitis (HP:0000976)2.65229028
37Achilles tendon contracture (HP:0001771)2.63880220
38Distal lower limb amyotrophy (HP:0008944)2.60648658
39Ketoacidosis (HP:0001993)2.50061509
40Progressive muscle weakness (HP:0003323)2.49642860
41Xanthomatosis (HP:0000991)2.48391970
42Oligomenorrhea (HP:0000876)2.47879421
43Hypokinesia (HP:0002375)2.45025371
44Poor suck (HP:0002033)2.44750724
45Myokymia (HP:0002411)2.44468621
46Lactic acidosis (HP:0003128)2.44372215
47Increased cerebral lipofuscin (HP:0011813)2.44047207
48Epileptic encephalopathy (HP:0200134)2.43378497
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42319304
50Epileptiform EEG discharges (HP:0011182)2.41842175
51Asymmetric septal hypertrophy (HP:0001670)2.40725890
52Cholelithiasis (HP:0001081)2.38949899
53Loss of speech (HP:0002371)2.36705730
54Hyperammonemia (HP:0001987)2.36640847
55Abnormality of the Achilles tendon (HP:0005109)2.35922894
56Mucopolysacchariduria (HP:0008155)2.35470284
57Urinary glycosaminoglycan excretion (HP:0003541)2.35470284
58J-shaped sella turcica (HP:0002680)2.35468982
59Abnormal gallbladder morphology (HP:0012437)2.35287873
60EEG with generalized epileptiform discharges (HP:0011198)2.35259801
61Myopathic facies (HP:0002058)2.33560681
62Axonal loss (HP:0003447)2.32757403
63Methylmalonic aciduria (HP:0012120)2.31157744
64Exercise-induced myalgia (HP:0003738)2.30728617
65Lethargy (HP:0001254)2.30377484
66Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29839550
67Abnormality of polysaccharide metabolism (HP:0011012)2.29839550
68Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29839550
69Abnormality of the lower motor neuron (HP:0002366)2.29567659
70CNS demyelination (HP:0007305)2.27559595
71Myoglobinuria (HP:0002913)2.26774783
72Hypsarrhythmia (HP:0002521)2.24600883
73Hyperlipoproteinemia (HP:0010980)2.22982423
74Brushfield spots (HP:0001088)2.22949814
75Abnormality of serine family amino acid metabolism (HP:0010894)2.18610912
76Abnormality of glycine metabolism (HP:0010895)2.18610912
77Respiratory failure (HP:0002878)2.18293007
78Conjunctival hamartoma (HP:0100780)2.18022726
79Difficulty climbing stairs (HP:0003551)2.16830242
80Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15896793
81Spastic gait (HP:0002064)2.15733214
82Abnormality of the distal phalanges of the toes (HP:0010182)2.15084697
83Exercise-induced muscle cramps (HP:0003710)2.15023062
84Muscle fiber inclusion bodies (HP:0100299)2.14838691
85Abnormality of macrophages (HP:0004311)2.14249708
86Abnormality of fatty-acid metabolism (HP:0004359)2.13105269
87Thin bony cortex (HP:0002753)2.12764269
88Type 1 muscle fiber predominance (HP:0003803)2.11315302
89Cerebral aneurysm (HP:0004944)2.11238107
90Systemic lupus erythematosus (HP:0002725)2.11031652
91Neoplasm of the adrenal gland (HP:0100631)2.10615860
92Cervical subluxation (HP:0003308)2.10031137
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.09452286
94Osteolytic defects of the hand bones (HP:0009699)2.09452286
95Emotional lability (HP:0000712)2.08854229
96Cerebral inclusion bodies (HP:0100314)2.08777432
97Protrusio acetabuli (HP:0003179)2.08401055
98Nemaline bodies (HP:0003798)2.08211240
99Distal upper limb amyotrophy (HP:0007149)2.06666233
100Upper limb amyotrophy (HP:0009129)2.06666233
101Supranuclear gaze palsy (HP:0000605)2.06239507
102Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.05195769
103Abnormality of skeletal muscle fiber size (HP:0012084)2.05120425
104Leukodystrophy (HP:0002415)2.04907916
105Hypolipoproteinemia (HP:0010981)2.04165099
106Rhabdomyolysis (HP:0003201)2.04077912
107Increased neuronal autofluorescent lipopigment (HP:0002074)2.03620264
108Neuronal loss in central nervous system (HP:0002529)2.02966695
109Dicarboxylic aciduria (HP:0003215)2.02723422
110Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02723422
111Broad face (HP:0000283)2.02253125
112Cellulitis (HP:0100658)2.02133428
113Hemorrhage of the eye (HP:0011885)2.02096685
114Hypoglycemic coma (HP:0001325)2.01873316
115Failure to thrive in infancy (HP:0001531)2.01726086
116Absence seizures (HP:0002121)2.01224496
117Abnormality of methionine metabolism (HP:0010901)2.00970634
118Hyperglycinuria (HP:0003108)2.00952422
119Delusions (HP:0000746)2.00839845
120Infertility (HP:0000789)2.00087507
121Interstitial pulmonary disease (HP:0006530)1.99918006
122Cerebral hypomyelination (HP:0006808)1.98821275
123Generalized tonic-clonic seizures (HP:0002069)1.98176850
124Fatigue (HP:0012378)1.97416525
125Short nail (HP:0001799)1.97017431
126Hyporeflexia of lower limbs (HP:0002600)1.95929455
127Ragged-red muscle fibers (HP:0003200)1.95333765
128Impaired vibration sensation in the lower limbs (HP:0002166)1.95267839
129Abnormality of sulfur amino acid metabolism (HP:0004339)1.95080953
130Increased variability in muscle fiber diameter (HP:0003557)1.94879677
131Abnormality of pain sensation (HP:0010832)1.93650523
132Impaired pain sensation (HP:0007328)1.93650523
133Increased serum lactate (HP:0002151)1.93643039
134Hyperthyroidism (HP:0000836)1.92827357
135Slow saccadic eye movements (HP:0000514)1.92365800
136Abnormality of serum amino acid levels (HP:0003112)1.91517400
137Retinal atrophy (HP:0001105)1.88590000
138Nuclear cataract (HP:0100018)1.88544169
139Neurofibrillary tangles (HP:0002185)1.88227231
140Delayed gross motor development (HP:0002194)1.87587178
141Obstructive sleep apnea (HP:0002870)1.87557164
142Anxiety (HP:0000739)1.87443854
143Abnormality of the gallbladder (HP:0005264)1.85617532
144Progressive external ophthalmoplegia (HP:0000590)1.85546206
145Focal seizures (HP:0007359)1.85369003
146Hamartoma of the eye (HP:0010568)1.84256168
147Metabolic acidosis (HP:0001942)1.84172186
148Mildly elevated creatine phosphokinase (HP:0008180)1.83957037
149Neoplasm of the peripheral nervous system (HP:0100007)1.83924234
150Hyperinsulinemic hypoglycemia (HP:0000825)1.83670328
151Flat acetabular roof (HP:0003180)1.83060611
152Insomnia (HP:0100785)1.83041235
153Visual hallucinations (HP:0002367)1.82113050
154Agitation (HP:0000713)1.81830078
155Generalized amyotrophy (HP:0003700)1.81111811
156Increased IgE level (HP:0003212)1.80291361
157Muscular hypotonia of the trunk (HP:0008936)1.79840774
158Dialeptic seizures (HP:0011146)1.79235269
159Clonus (HP:0002169)1.79146904
160Autoamputation (HP:0001218)1.78369862
161Increased serum ferritin (HP:0003281)1.77491366
162Insidious onset (HP:0003587)1.77205307
163Termporal pattern (HP:0011008)1.77205307
164Spastic paraparesis (HP:0002313)1.77024825
165Sensorimotor neuropathy (HP:0007141)1.76977611
166Lower limb amyotrophy (HP:0007210)1.76711835
167Increased muscle lipid content (HP:0009058)1.76670045
168Abnormality of aspartate family amino acid metabolism (HP:0010899)1.76351238
169Abnormality of the thoracic spine (HP:0100711)1.74711002
170Trismus (HP:0000211)1.73916663
171Reduced subcutaneous adipose tissue (HP:0003758)1.73879309
172Progressive neurologic deterioration (HP:0002344)1.71324271
173Polygenic inheritance (HP:0010982)1.71315287
174Bone pain (HP:0002653)1.71135037
175Spinal rigidity (HP:0003306)1.69683814
176Natal tooth (HP:0000695)1.69489448
177Myocardial infarction (HP:0001658)1.69449529
178EMG: myopathic abnormalities (HP:0003458)1.69361263
179Apathy (HP:0000741)1.68726000
180Sparse lateral eyebrow (HP:0005338)1.67814851
181Neck muscle weakness (HP:0000467)1.65812065
182Back pain (HP:0003418)1.65430389
183Gastrointestinal stroma tumor (HP:0100723)1.65372367
184Foot dorsiflexor weakness (HP:0009027)1.63532441
185Hepatosplenomegaly (HP:0001433)1.63358386
186Dilatation of the ascending aorta (HP:0005111)1.61509556
187Rigidity (HP:0002063)1.61095718
188Rough bone trabeculation (HP:0100670)1.61058028
189Abnormality of oral frenula (HP:0000190)1.60979809
190Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.60702062
191Bulbar palsy (HP:0001283)1.59536720
192Diminished motivation (HP:0000745)1.59026680
193Recurrent abscess formation (HP:0002722)1.58830662
194Aneurysm (HP:0002617)1.58681864

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.93222662
2INSRR3.60909174
3ERN13.53961622
4CASK3.52732389
5FRK3.52578372
6PDK33.51139196
7PDK43.51139196
8SMG12.83983810
9BCKDK2.76928387
10TSSK62.70893728
11MAP2K72.63104370
12MAP3K42.57638868
13NTRK32.52436673
14PRKD32.49486913
15TESK22.42000786
16AKT32.31688319
17IRAK32.31524382
18TTN2.17322241
19MAP3K132.15373704
20PDK22.13511972
21NME22.13142956
22RIPK12.10208103
23MAP3K92.09190397
24ICK2.06828097
25TESK11.99547202
26BRAF1.99341244
27CDK191.99022333
28EPHA21.88976293
29CCNB11.85947582
30MAP2K31.84609610
31MAP2K41.74416083
32MAP3K31.68755661
33FGFR21.64289371
34MAP3K121.63077545
35PKN21.61438060
36NME11.58716212
37MAPKAPK51.56996228
38CDK121.55808282
39TBK11.53504931
40DAPK21.51649604
41MAP3K141.49537737
42OXSR11.45033686
43PINK11.42891505
44TAOK21.41860493
45PAK41.40252930
46DAPK11.36237305
47OBSCN1.35157239
48BUB11.32068565
49MAP3K111.27649882
50NEK11.27179603
51ARAF1.26277225
52MST1R1.25120969
53MINK11.18245227
54MAPK111.18016455
55EIF2AK11.17341557
56PNCK1.15050301
57KSR21.13931894
58PIM21.12301535
59PTK2B1.08017005
60PHKG21.07868007
61PHKG11.07868007
62PLK21.06742255
63PRKCG1.04141970
64PDGFRA1.03509737
65TYK21.03389376
66TAOK10.99854399
67EPHA40.97087433
68PRKD20.96162584
69MAPKAPK30.96005618
70ZAP700.94804617
71WNK40.93101437
72MAP4K10.93032611
73RIPK40.92883950
74SGK4940.92279594
75SGK2230.92279594
76ERBB40.88533767
77MTOR0.83585204
78CDK50.83250348
79PTK60.82634957
80MAP2K10.81999076
81CAMK2A0.81147375
82MAP3K80.80746048
83NEK60.80685908
84PLK30.79256237
85TAOK30.76063849
86LIMK10.75870148
87CDC42BPA0.75777694
88MARK10.75545936
89SIK10.74762392
90STK380.74183158
91MYLK0.73296080
92JAK30.72745190
93EEF2K0.72718438
94PBK0.72176259
95BLK0.71850212
96PRPF4B0.70808913
97PAK60.70166410
98PTK20.70064620
99LMTK20.69796843
100RPS6KB20.69263947
101STK390.67899866
102JAK10.66665358
103CSK0.65074516
104NTRK10.64988241
105STK100.64739012
106DAPK30.64272871
107CAMK2B0.64231573
108MAPK130.63174944
109LRRK20.62827084
110MOS0.62326892
111RAF10.61837913
112PRKCZ0.61738076
113CAMK2G0.61720234
114NTRK20.61714130
115MARK20.60235526
116KSR10.59941346
117PRKCH0.59795758
118EPHB10.58175949
119TNK20.58046626
120BMX0.57856229
121CAMKK10.57298696
122PDK10.54033849
123SGK20.52818088
124PDPK10.52767229
125SCYL20.52583720
126STK160.51985611
127HIPK20.51295979
128MAP2K20.51244908
129RET0.51227379
130PKN10.50857599
131CDK60.49930937
132IRAK40.49408471
133PRKG20.48553252
134CAMK2D0.47392653
135PRKCI0.45049827
136MAPKAPK20.44913566
137IKBKB0.44103864
138RPS6KA20.43367587
139MAP3K20.43165971
140GRK60.43061183
141SIK30.42784661
142IRAK20.42755274
143LATS20.42671361
144MAPK120.42220214
145DMPK0.42060675
146JAK20.41872834
147MAP3K10.41472417
148IKBKE0.41376501
149CDK140.40810330
150CDK180.40468676
151AKT20.40421000
152BCR0.39754915
153PAK30.39640225
154CSNK1G30.38607489
155CDK80.38379786
156ALK0.37337084
157CDK70.37145500
158PRKACB0.36839810
159STK110.36386408
160CDK150.35584621
161PRKAA10.35500615
162GRK50.35118073
163CDK40.34976668
164CSNK1G20.34945002
165EIF2AK30.33478992
166RPS6KA30.33002395
167HCK0.32937984
168FGFR40.31957026
169PRKCE0.31887018
170SGK30.31451547
171DDR20.30869344
172FER0.30577712
173CSF1R0.30360782

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.53061451
2Other glycan degradation_Homo sapiens_hsa005113.49929662
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.47397231
4Vitamin B6 metabolism_Homo sapiens_hsa007502.92730349
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72919099
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67152793
7Pyruvate metabolism_Homo sapiens_hsa006202.55208646
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.54643708
9Synaptic vesicle cycle_Homo sapiens_hsa047212.51771888
10Propanoate metabolism_Homo sapiens_hsa006402.48982893
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.23005098
12Arginine biosynthesis_Homo sapiens_hsa002202.12421719
13Collecting duct acid secretion_Homo sapiens_hsa049662.11976467
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.08027403
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.07223923
16Oxidative phosphorylation_Homo sapiens_hsa001902.05696970
17Glycosaminoglycan degradation_Homo sapiens_hsa005312.00634104
18Lysosome_Homo sapiens_hsa041421.98650827
19Butanoate metabolism_Homo sapiens_hsa006501.96635538
20Acute myeloid leukemia_Homo sapiens_hsa052211.94723659
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87979295
22Fatty acid elongation_Homo sapiens_hsa000621.87462857
23Carbon metabolism_Homo sapiens_hsa012001.82137666
24Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.81654581
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.77734028
26Parkinsons disease_Homo sapiens_hsa050121.75434939
27Biosynthesis of amino acids_Homo sapiens_hsa012301.71892999
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70385641
29Fatty acid degradation_Homo sapiens_hsa000711.66149008
30Fatty acid metabolism_Homo sapiens_hsa012121.64285713
31Chronic myeloid leukemia_Homo sapiens_hsa052201.57863566
32Prion diseases_Homo sapiens_hsa050201.56990140
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53256633
34Central carbon metabolism in cancer_Homo sapiens_hsa052301.50236475
35B cell receptor signaling pathway_Homo sapiens_hsa046621.48829627
36Bladder cancer_Homo sapiens_hsa052191.47665628
37Osteoclast differentiation_Homo sapiens_hsa043801.46166822
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44498974
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.42921980
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.40763019
41Tryptophan metabolism_Homo sapiens_hsa003801.40218625
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40020711
43Shigellosis_Homo sapiens_hsa051311.39367988
44VEGF signaling pathway_Homo sapiens_hsa043701.37372757
45Vibrio cholerae infection_Homo sapiens_hsa051101.34195709
46Non-small cell lung cancer_Homo sapiens_hsa052231.32468464
47Sulfur metabolism_Homo sapiens_hsa009201.25531703
48Proteasome_Homo sapiens_hsa030501.23233444
49Pancreatic cancer_Homo sapiens_hsa052121.21277629
50Nicotine addiction_Homo sapiens_hsa050331.20897852
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20313001
52Hepatitis C_Homo sapiens_hsa051601.17519673
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.16498210
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16491196
55Huntingtons disease_Homo sapiens_hsa050161.14273470
56Peroxisome_Homo sapiens_hsa041461.14154149
57TNF signaling pathway_Homo sapiens_hsa046681.13879560
58Thyroid cancer_Homo sapiens_hsa052161.12327382
59Alzheimers disease_Homo sapiens_hsa050101.09549472
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.07555265
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06076042
62Nitrogen metabolism_Homo sapiens_hsa009101.05861947
63Insulin secretion_Homo sapiens_hsa049111.04174583
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03853913
65Insulin signaling pathway_Homo sapiens_hsa049101.00114346
66Tuberculosis_Homo sapiens_hsa051520.99672002
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.98737968
68Hepatitis B_Homo sapiens_hsa051610.98490314
69Endocytosis_Homo sapiens_hsa041440.97886331
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.96942032
71Influenza A_Homo sapiens_hsa051640.96484456
72Apoptosis_Homo sapiens_hsa042100.96152921
73Phenylalanine metabolism_Homo sapiens_hsa003600.95981635
74Toxoplasmosis_Homo sapiens_hsa051450.94940843
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.94787021
76Protein export_Homo sapiens_hsa030600.94498359
77Insulin resistance_Homo sapiens_hsa049310.94375644
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93465425
79Adipocytokine signaling pathway_Homo sapiens_hsa049200.92904754
80T cell receptor signaling pathway_Homo sapiens_hsa046600.92551933
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.92422293
82Regulation of autophagy_Homo sapiens_hsa041400.91944912
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.91889686
84GABAergic synapse_Homo sapiens_hsa047270.91238444
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90353501
86Endometrial cancer_Homo sapiens_hsa052130.89366073
87beta-Alanine metabolism_Homo sapiens_hsa004100.89291224
88PPAR signaling pathway_Homo sapiens_hsa033200.88259613
89Amoebiasis_Homo sapiens_hsa051460.87468334
90Primary immunodeficiency_Homo sapiens_hsa053400.87299333
91Prolactin signaling pathway_Homo sapiens_hsa049170.86097160
92Complement and coagulation cascades_Homo sapiens_hsa046100.86083402
93Salmonella infection_Homo sapiens_hsa051320.85578816
94Leishmaniasis_Homo sapiens_hsa051400.85167916
95mTOR signaling pathway_Homo sapiens_hsa041500.83125658
96Cardiac muscle contraction_Homo sapiens_hsa042600.83122794
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81603302
98Selenocompound metabolism_Homo sapiens_hsa004500.81355635
99Bile secretion_Homo sapiens_hsa049760.81288539
100Tyrosine metabolism_Homo sapiens_hsa003500.81144122
101Measles_Homo sapiens_hsa051620.79646284
102Herpes simplex infection_Homo sapiens_hsa051680.79366137
103Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79332734
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.78514201
105Fructose and mannose metabolism_Homo sapiens_hsa000510.78251478
106N-Glycan biosynthesis_Homo sapiens_hsa005100.77423506
107Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.77380242
108Arginine and proline metabolism_Homo sapiens_hsa003300.77216409
109Glucagon signaling pathway_Homo sapiens_hsa049220.76995325
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76234898
111HIF-1 signaling pathway_Homo sapiens_hsa040660.74905254
112Proteoglycans in cancer_Homo sapiens_hsa052050.74697203
113Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74589841
114Viral myocarditis_Homo sapiens_hsa054160.74164615
115Renal cell carcinoma_Homo sapiens_hsa052110.73852057
116Small cell lung cancer_Homo sapiens_hsa052220.73694679
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73650695
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73262453
119AMPK signaling pathway_Homo sapiens_hsa041520.73131635
120Pertussis_Homo sapiens_hsa051330.72983804
121Amphetamine addiction_Homo sapiens_hsa050310.72702434
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72115112
123Glioma_Homo sapiens_hsa052140.71107243
124Fat digestion and absorption_Homo sapiens_hsa049750.70029502
125Legionellosis_Homo sapiens_hsa051340.69559667
126HTLV-I infection_Homo sapiens_hsa051660.69111873
127Epstein-Barr virus infection_Homo sapiens_hsa051690.68469380
128Notch signaling pathway_Homo sapiens_hsa043300.68354880
129Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68077273
130Histidine metabolism_Homo sapiens_hsa003400.66818933
131Glycerolipid metabolism_Homo sapiens_hsa005610.66739443
132Pentose phosphate pathway_Homo sapiens_hsa000300.66658907
133Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65430395
134Inositol phosphate metabolism_Homo sapiens_hsa005620.65006080
135Viral carcinogenesis_Homo sapiens_hsa052030.64722914
136Long-term potentiation_Homo sapiens_hsa047200.63079036
137Metabolic pathways_Homo sapiens_hsa011000.62962330
138Focal adhesion_Homo sapiens_hsa045100.62593990
139Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62221446
140Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62148987
141Dopaminergic synapse_Homo sapiens_hsa047280.61110667
142Folate biosynthesis_Homo sapiens_hsa007900.60935387
143GnRH signaling pathway_Homo sapiens_hsa049120.60476211
144Glycerophospholipid metabolism_Homo sapiens_hsa005640.59576128
145Antigen processing and presentation_Homo sapiens_hsa046120.58977891
146ErbB signaling pathway_Homo sapiens_hsa040120.58587273
147Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.58482676
148Prostate cancer_Homo sapiens_hsa052150.57578317
149Estrogen signaling pathway_Homo sapiens_hsa049150.57034539
150Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56070155
151Circadian entrainment_Homo sapiens_hsa047130.52781667
152Galactose metabolism_Homo sapiens_hsa000520.52456905
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51190773
154Steroid biosynthesis_Homo sapiens_hsa001000.50528985
155Glutamatergic synapse_Homo sapiens_hsa047240.49929261
156Olfactory transduction_Homo sapiens_hsa047400.49283507
157Phagosome_Homo sapiens_hsa041450.48011404
158Lysine degradation_Homo sapiens_hsa003100.47864014
159Phospholipase D signaling pathway_Homo sapiens_hsa040720.47202928
160Drug metabolism - other enzymes_Homo sapiens_hsa009830.46105850
161Morphine addiction_Homo sapiens_hsa050320.45018137
162Starch and sucrose metabolism_Homo sapiens_hsa005000.44584733
163Choline metabolism in cancer_Homo sapiens_hsa052310.44322904
164Cocaine addiction_Homo sapiens_hsa050300.44288331
165Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43116798
166Long-term depression_Homo sapiens_hsa047300.39469680
167Sulfur relay system_Homo sapiens_hsa041220.38299584
168Chemical carcinogenesis_Homo sapiens_hsa052040.37598330
169ABC transporters_Homo sapiens_hsa020100.37147829
170Renin secretion_Homo sapiens_hsa049240.35080529
171Salivary secretion_Homo sapiens_hsa049700.34899629
172Ovarian steroidogenesis_Homo sapiens_hsa049130.33752817
173Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33553776
174Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33299831
175Steroid hormone biosynthesis_Homo sapiens_hsa001400.33027484
176Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32064283
177Serotonergic synapse_Homo sapiens_hsa047260.31710887
178Taste transduction_Homo sapiens_hsa047420.31143297
179Cyanoamino acid metabolism_Homo sapiens_hsa004600.29784168
180alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.28265675
181Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27265407

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