ABCG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.29124358
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.43520461
3neutrophil activation (GO:0042119)4.76573735
4granulocyte activation (GO:0036230)4.41389665
5positive regulation of antigen processing and presentation (GO:0002579)4.38262989
6regulation of dendritic cell antigen processing and presentation (GO:0002604)4.37063694
7type I interferon signaling pathway (GO:0060337)4.27562227
8cellular response to type I interferon (GO:0071357)4.27562227
9positive regulation of interferon-alpha production (GO:0032727)4.20928473
10response to type I interferon (GO:0034340)4.18911873
11positive regulation of gamma-delta T cell activation (GO:0046645)4.04463977
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.04266369
13negative regulation of cell killing (GO:0031342)4.04266369
14regulation of activation of Janus kinase activity (GO:0010533)4.02945171
15regulation of interferon-alpha production (GO:0032647)3.92306435
16myeloid dendritic cell activation (GO:0001773)3.87965193
17myeloid dendritic cell differentiation (GO:0043011)3.87114988
18regulation of RIG-I signaling pathway (GO:0039535)3.83919930
19positive regulation of natural killer cell differentiation (GO:0032825)3.82903413
20regulation of antigen processing and presentation (GO:0002577)3.78135740
21response to peptidoglycan (GO:0032494)3.76454426
22positive regulation of cellular amide metabolic process (GO:0034250)3.70527348
23interferon-gamma-mediated signaling pathway (GO:0060333)3.64704551
24antigen processing and presentation of endogenous antigen (GO:0019883)3.62683169
25negative regulation of viral genome replication (GO:0045071)3.57585278
26T-helper 1 type immune response (GO:0042088)3.56938690
27immunoglobulin mediated immune response (GO:0016064)3.50011808
28respiratory burst (GO:0045730)3.49299641
29positive regulation of interleukin-12 production (GO:0032735)3.48371204
30myeloid cell activation involved in immune response (GO:0002275)3.44498199
31dendritic cell chemotaxis (GO:0002407)3.44113073
32positive regulation of type 2 immune response (GO:0002830)3.43304025
33positive regulation by symbiont of host defense response (GO:0052509)3.42314594
34modulation by symbiont of host defense response (GO:0052031)3.42314594
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.42314594
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.42314594
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.42314594
38modulation by symbiont of host immune response (GO:0052553)3.42314594
39cellular response to zinc ion (GO:0071294)3.42152204
40regulation of gamma-delta T cell activation (GO:0046643)3.40274066
41detection of other organism (GO:0098543)3.34847426
42regulation of gamma-delta T cell differentiation (GO:0045586)3.33117059
43dendritic cell differentiation (GO:0097028)3.32367641
44production of molecular mediator involved in inflammatory response (GO:0002532)3.27431093
45myeloid leukocyte activation (GO:0002274)3.25565333
46positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25252194
47positive regulation of monocyte chemotaxis (GO:0090026)3.24562190
48mast cell activation (GO:0045576)3.23134834
49regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.22962955
50negative regulation of interleukin-17 production (GO:0032700)3.22036980
51regulation of interferon-beta biosynthetic process (GO:0045357)3.20265246
52macrophage activation involved in immune response (GO:0002281)3.19550449
53defense response to protozoan (GO:0042832)3.18595073
54superoxide anion generation (GO:0042554)3.18369521
55regulation of hypersensitivity (GO:0002883)3.18305311
56sequestering of actin monomers (GO:0042989)3.15722734
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.13941630
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.13941630
59response to muramyl dipeptide (GO:0032495)3.13736954
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.12561371
61regulation of B cell receptor signaling pathway (GO:0050855)3.12330916
62regulation of T-helper 1 cell differentiation (GO:0045625)3.11212406
63monocyte chemotaxis (GO:0002548)3.10461454
64cellular extravasation (GO:0045123)3.08512201
65detection of bacterium (GO:0016045)3.06627035
66dendritic cell migration (GO:0036336)3.05629317
67regulation of T-helper 2 cell differentiation (GO:0045628)3.05144566
68regulation of mast cell degranulation (GO:0043304)3.04190665
69cellular response to interferon-beta (GO:0035458)3.03481941
70hydrogen peroxide biosynthetic process (GO:0050665)3.03343719
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.03110296
72leukocyte degranulation (GO:0043299)3.01896227
73eosinophil chemotaxis (GO:0048245)3.01217235
74positive regulation of T cell migration (GO:2000406)3.00882282
75cellular response to exogenous dsRNA (GO:0071360)2.99329579
76positive regulation of interferon-beta production (GO:0032728)2.98565596
77NIK/NF-kappaB signaling (GO:0038061)2.96248742
78regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95636603
79positive regulation of mast cell activation involved in immune response (GO:0033008)2.94105935
80positive regulation of mast cell degranulation (GO:0043306)2.94105935
81regulation of interleukin-12 biosynthetic process (GO:0045075)2.93892790
82natural killer cell mediated immunity (GO:0002228)2.93019544
83natural killer cell mediated cytotoxicity (GO:0042267)2.93019544
84macrophage activation (GO:0042116)2.93004671
85regulation of mast cell activation (GO:0033003)2.92666174
86detection of external biotic stimulus (GO:0098581)2.91310342
87detection of molecule of bacterial origin (GO:0032490)2.91157082
88response to interferon-beta (GO:0035456)2.90748533
89negative regulation of mast cell activation (GO:0033004)2.88867833
90positive regulation of mast cell activation (GO:0033005)2.87684173
91G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.87196835
92regulation of interleukin-17 production (GO:0032660)2.86421803
93positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86173749
94cellular response to virus (GO:0098586)2.85341350
95positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.82091973
96lipoxygenase pathway (GO:0019372)2.80425110
97response to interferon-alpha (GO:0035455)2.80287098
98response to host immune response (GO:0052572)2.79905108
99response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.79905108
100purinergic nucleotide receptor signaling pathway (GO:0035590)2.79220458
101microglial cell activation (GO:0001774)2.79217733
102regulation of mast cell activation involved in immune response (GO:0033006)2.78672193
103positive regulation of lymphocyte migration (GO:2000403)2.78310490
104positive regulation of T-helper cell differentiation (GO:0045624)2.78000067
105leukocyte mediated cytotoxicity (GO:0001909)2.77651003
106regulation of T cell tolerance induction (GO:0002664)2.77408375
107germinal center formation (GO:0002467)2.76037305
108response to protozoan (GO:0001562)2.73698797
109negative thymic T cell selection (GO:0045060)2.72898129
110positive regulation of T cell chemotaxis (GO:0010820)2.71688895
111regulation of T cell chemotaxis (GO:0010819)2.71688895
112positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.70397078
113negative regulation of interleukin-12 production (GO:0032695)2.65783205
114negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.51237845
115negative regulation of lymphocyte mediated immunity (GO:0002707)2.45300945
116detection of biotic stimulus (GO:0009595)2.43221885
117negative regulation of erythrocyte differentiation (GO:0045647)2.42834190
118negative regulation of glycoprotein biosynthetic process (GO:0010561)2.38433387
119CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.33410780
120T-helper cell differentiation (GO:0042093)2.33410780
121negative regulation of leukocyte mediated immunity (GO:0002704)2.32535883
122tolerance induction (GO:0002507)2.31769534
123response to interleukin-15 (GO:0070672)2.31297877
124regulation of leukocyte degranulation (GO:0043300)2.30758693
125negative regulation of innate immune response (GO:0045824)2.30758657
126macroautophagy (GO:0016236)2.30387193
127T cell selection (GO:0045058)2.27064704
128negative regulation of interleukin-6 production (GO:0032715)2.26801339
129interleukin-1-mediated signaling pathway (GO:0070498)2.26744996
130regulation of myeloid leukocyte mediated immunity (GO:0002886)2.26534678
131regulation of tolerance induction (GO:0002643)2.23824231
132cellular response to interleukin-15 (GO:0071350)2.23407333
133positive thymic T cell selection (GO:0045059)2.23020379
134negative T cell selection (GO:0043383)2.20889987
135negative regulation of T cell mediated immunity (GO:0002710)2.19800670
136positive regulation of Rap GTPase activity (GO:0032854)2.19057013
137regulation of cellular extravasation (GO:0002691)2.14545011
138* positive regulation of cholesterol efflux (GO:0010875)2.14415929
139regulation of T cell mediated cytotoxicity (GO:0001914)2.14314076
140negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.14199452
141regulation of beta-amyloid formation (GO:1902003)2.14036669
142positive regulation of toll-like receptor signaling pathway (GO:0034123)2.13518374
143response to host (GO:0075136)2.13339680
144response to host defenses (GO:0052200)2.13339680
145response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.13339680
146regulation of germinal center formation (GO:0002634)2.12782760
147B cell receptor signaling pathway (GO:0050853)2.12633445
148negative regulation of T-helper cell differentiation (GO:0045623)2.11872871
149negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.11872871

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.11262223
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.92280783
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.60354525
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.87589895
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.54547532
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.99092502
7* IRF8_27001747_Chip-Seq_BMDM_Mouse3.62456023
8* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31541428
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07615112
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.00393792
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.90839231
12NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76249874
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70361870
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61924851
15STAT4_19710469_ChIP-ChIP_TH1__Mouse2.41805086
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39608486
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.28548477
18RUNX_20019798_ChIP-Seq_JUKART_Human2.10643296
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.07546042
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07529968
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.93327561
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.83435378
23VDR_24787735_ChIP-Seq_THP-1_Human1.81024516
24* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.78584024
25PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.75475414
26SCL_19346495_ChIP-Seq_HPC-7_Human1.74984933
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74578607
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.73396179
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.60860812
30ESR1_21235772_ChIP-Seq_MCF-7_Human1.59587601
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.58572102
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56369694
33* SPI1_23547873_ChIP-Seq_NB4_Human1.55943543
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.54403070
35TCF7_22412390_ChIP-Seq_EML_Mouse1.53886294
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53366907
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52074424
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50555749
39MYB_26560356_Chip-Seq_TH2_Human1.49981021
40GATA1_22025678_ChIP-Seq_K562_Human1.49599598
41PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.48379390
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45935974
43* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42654793
44VDR_21846776_ChIP-Seq_THP-1_Human1.39870936
45* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39537976
46PU_27001747_Chip-Seq_BMDM_Mouse1.38468751
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.37340525
48KDM2B_26808549_Chip-Seq_DND41_Human1.36890731
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.36624815
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29101306
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26769182
52CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24764753
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23449520
54UTX_26944678_Chip-Seq_JUKART_Human1.23395605
55GATA3_26560356_Chip-Seq_TH2_Human1.22719446
56* SPI1_23127762_ChIP-Seq_K562_Human1.22528383
57* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22227139
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.21833362
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.21833362
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20532872
61LXR_22292898_ChIP-Seq_THP-1_Human1.20397832
62GATA1_19941826_ChIP-Seq_K562_Human1.19044210
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18755623
64VDR_24763502_ChIP-Seq_THP-1_Human1.18612257
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14283955
66* DROSHA_22980978_ChIP-Seq_HELA_Human1.12794957
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11501543
68PPARA_22158963_ChIP-Seq_LIVER_Mouse1.10900086
69MYB_26560356_Chip-Seq_TH1_Human1.10510458
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10230128
71RACK7_27058665_Chip-Seq_MCF-7_Human1.10148868
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10048017
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.08607762
74* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08530930
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07666323
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07297210
77* LXR_22158963_ChIP-Seq_LIVER_Mouse1.06079969
78* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05463625
79GBX2_23144817_ChIP-Seq_PC3_Human1.05399036
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05306358
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.04602690
82GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04485871
83* RUNX1_22412390_ChIP-Seq_EML_Mouse1.03772727
84EGR1_19032775_ChIP-ChIP_M12_Human1.02370576
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01379436
86FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01120451
87RUNX1_27514584_Chip-Seq_MCF-7_Human1.01090893
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.99535924
89GATA3_27048872_Chip-Seq_THYMUS_Human0.98908246
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.98638312
91MAF_26560356_Chip-Seq_TH2_Human0.98371553
92PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97901414
93FLI1_27457419_Chip-Seq_LIVER_Mouse0.97543433
94* KDM2B_26808549_Chip-Seq_K562_Human0.96797024
95STAT3_18555785_Chip-Seq_ESCs_Mouse0.95863446
96AHR_22903824_ChIP-Seq_MCF-7_Human0.95649391
97PU1_27457419_Chip-Seq_LIVER_Mouse0.95151815
98GATA2_19941826_ChIP-Seq_K562_Human0.95129671
99TP53_18474530_ChIP-ChIP_U2OS_Human0.94686350
100SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94579459
101SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94190366
102EGR1_19374776_ChIP-ChIP_THP-1_Human0.93852504
103KDM2B_26808549_Chip-Seq_JURKAT_Human0.93148767
104* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92926133
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92608142
106CMYC_18555785_Chip-Seq_ESCs_Mouse0.91498069
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91445913
108P53_22387025_ChIP-Seq_ESCs_Mouse0.91160941
109* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90293443
110* BCL6_27268052_Chip-Seq_Bcells_Human0.89842315
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.89698558
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88997283
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88012760
114P300_19829295_ChIP-Seq_ESCs_Human0.87163588
115NMYC_18555785_Chip-Seq_ESCs_Mouse0.87028882
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86506152
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86388749
118E2F1_18555785_Chip-Seq_ESCs_Mouse0.84998520
119* BCOR_27268052_Chip-Seq_Bcells_Human0.84422358
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.84357979
121EZH2_27294783_Chip-Seq_NPCs_Mouse0.84147394
122NANOG_18555785_Chip-Seq_ESCs_Mouse0.84039656
123MAF_26560356_Chip-Seq_TH1_Human0.83826377
124RUNX1_27457419_Chip-Seq_LIVER_Mouse0.83589191
125POU3F2_20337985_ChIP-ChIP_501MEL_Human0.83304199
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83012410
127IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82920515
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82103384
129P300_18555785_Chip-Seq_ESCs_Mouse0.82019902
130SMRT_27268052_Chip-Seq_Bcells_Human0.81533761
131SOX2_18555785_Chip-Seq_ESCs_Mouse0.80996961
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.80977626
133TBX20_22328084_ChIP-Seq_HEART_Mouse0.79435292
134TBX20_22080862_ChIP-Seq_HEART_Mouse0.79435292
135EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.79402360
136SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78928375
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.78315061
138SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77268881
139* SOX2_20726797_ChIP-Seq_SW620_Human0.77074810
140SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76496978
141* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76361305
142RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.75838895
143TAF15_26573619_Chip-Seq_HEK293_Human0.74735572
144ZFX_18555785_Chip-Seq_ESCs_Mouse0.73213500
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.72979486
146EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.72910945
147SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.72188292

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation5.31302232
2MP0002148_abnormal_hypersensitivity_rea4.10565290
3MP0009785_altered_susceptibility_to3.63218989
4MP0001790_abnormal_immune_system3.23794479
5MP0005387_immune_system_phenotype3.23794479
6MP0005671_abnormal_response_to3.15313002
7MP0003436_decreased_susceptibility_to3.14391366
8MP0005000_abnormal_immune_tolerance3.06437194
9MP0000685_abnormal_immune_system2.91061427
10* MP0002419_abnormal_innate_immunity2.88155360
11MP0005025_abnormal_response_to2.78597671
12MP0003724_increased_susceptibility_to2.78561401
13MP0004510_myositis2.60662332
14* MP0002452_abnormal_antigen_presenting2.56520161
15* MP0002723_abnormal_immune_serum2.47491554
16MP0006082_CNS_inflammation2.43018098
17MP0001800_abnormal_humoral_immune2.42617533
18MP0005310_abnormal_salivary_gland2.41024426
19* MP0001819_abnormal_immune_cell2.31173927
20* MP0002420_abnormal_adaptive_immunity2.27544050
21* MP0003191_abnormal_cellular_cholesterol2.18394139
22MP0005058_abnormal_lysosome_morphology2.12561804
23MP0002277_abnormal_respiratory_mucosa2.09364360
24MP0002163_abnormal_gland_morphology2.07554251
25MP0002877_abnormal_melanocyte_morpholog1.97512800
26MP0003300_gastrointestinal_ulcer1.90808630
27MP0005167_abnormal_blood-brain_barrier1.86394405
28MP0005451_abnormal_body_composition1.85483706
29MP0005464_abnormal_platelet_physiology1.81544064
30MP0001346_abnormal_lacrimal_gland1.77419363
31* MP0002405_respiratory_system_inflammati1.76893130
32MP0001853_heart_inflammation1.71303201
33MP0003183_abnormal_peptide_metabolism1.69197564
34MP0002254_reproductive_system_inflammat1.63678592
35MP0001533_abnormal_skeleton_physiology1.62389879
36* MP0000716_abnormal_immune_system1.62000123
37MP0009764_decreased_sensitivity_to1.60972674
38MP0005379_endocrine/exocrine_gland_phen1.58822264
39MP0002166_altered_tumor_susceptibility1.57521064
40MP0002006_tumorigenesis1.56011953
41MP0001845_abnormal_inflammatory_respons1.55698361
42* MP0009840_abnormal_foam_cell1.55591276
43MP0001348_abnormal_lacrimal_gland1.53873893
44MP0003172_abnormal_lysosome_physiology1.53658785
45MP0002138_abnormal_hepatobiliary_system1.48740691
46MP0003763_abnormal_thymus_physiology1.47039755
47MP0010234_abnormal_vibrissa_follicle1.46016701
48MP0001986_abnormal_taste_sensitivity1.45343919
49MP0004381_abnormal_hair_follicle1.44365717
50MP0010155_abnormal_intestine_physiology1.44242299
51* MP0002398_abnormal_bone_marrow1.42982485
52MP0009278_abnormal_bone_marrow1.41701803
53MP0003075_altered_response_to1.39953307
54MP0002009_preneoplasia1.39597066
55MP0004130_abnormal_muscle_cell1.38674040
56MP0008469_abnormal_protein_level1.33264089
57MP0001873_stomach_inflammation1.31619277
58MP0002998_abnormal_bone_remodeling1.29801704
59MP0002876_abnormal_thyroid_physiology1.29114344
60MP0002332_abnormal_exercise_endurance1.21861295
61MP0005171_absent_coat_pigmentation1.20540847
62MP0010386_abnormal_urinary_bladder1.20425014
63MP0003448_altered_tumor_morphology1.20335187
64MP0009333_abnormal_splenocyte_physiolog1.17792132
65MP0005174_abnormal_tail_pigmentation1.17115561
66* MP0002429_abnormal_blood_cell1.17087277
67MP0004947_skin_inflammation1.17012141
68MP0000689_abnormal_spleen_morphology1.16061886
69MP0003690_abnormal_glial_cell1.16032718
70MP0000343_altered_response_to1.14733808
71MP0004484_altered_response_of1.14006584
72MP0000015_abnormal_ear_pigmentation1.13835945
73MP0003303_peritoneal_inflammation1.10644790
74MP0000372_irregular_coat_pigmentation1.10420332
75MP0002909_abnormal_adrenal_gland1.10338765
76MP0003329_amyloid_beta_deposits1.05604296
77MP0002722_abnormal_immune_system1.03657623
78MP0002132_abnormal_respiratory_system1.03483604
79MP0001765_abnormal_ion_homeostasis1.00828236
80MP0008004_abnormal_stomach_pH0.94957362
81MP0004264_abnormal_extraembryonic_tissu0.94306179
82MP0001545_abnormal_hematopoietic_system0.93517439
83MP0005397_hematopoietic_system_phenotyp0.93517439
84MP0000920_abnormal_myelination0.93387277
85MP0003186_abnormal_redox_activity0.92693172
86* MP0005535_abnormal_body_temperature0.92474151
87* MP0004782_abnormal_surfactant_physiolog0.91629587
88MP0000249_abnormal_blood_vessel0.91070423
89* MP0002971_abnormal_brown_adipose0.89652738
90MP0003879_abnormal_hair_cell0.88510289
91MP0003045_fibrosis0.87134145
92MP0002796_impaired_skin_barrier0.86861654
93MP0005365_abnormal_bile_salt0.84592413
94MP0001501_abnormal_sleep_pattern0.84420331
95MP0000858_altered_metastatic_potential0.83847735
96MP0000465_gastrointestinal_hemorrhage0.81711646
97MP0004883_abnormal_blood_vessel0.81291153
98MP0005334_abnormal_fat_pad0.81228478
99MP0002933_joint_inflammation0.79347682
100MP0009763_increased_sensitivity_to0.78235507
101MP0005166_decreased_susceptibility_to0.77135425
102* MP0002118_abnormal_lipid_homeostasis0.76568968
103MP0005666_abnormal_adipose_tissue0.76463678
104MP0000604_amyloidosis0.76400219
105MP0002638_abnormal_pupillary_reflex0.76043538
106MP0000681_abnormal_thyroid_gland0.75672656
107MP0008260_abnormal_autophagy0.75506807
108MP0001663_abnormal_digestive_system0.75336157
109MP0001502_abnormal_circadian_rhythm0.75228827
110MP0010329_abnormal_lipoprotein_level0.74280464
111MP0010678_abnormal_skin_adnexa0.73882805
112* MP0009115_abnormal_fat_cell0.73879639
113MP0008874_decreased_physiological_sensi0.73176054
114MP0005390_skeleton_phenotype0.72678937
115MP0001984_abnormal_olfaction0.70868654
116MP0004036_abnormal_muscle_relaxation0.68597412
117MP0009643_abnormal_urine_homeostasis0.68227010
118MP0008789_abnormal_olfactory_epithelium0.65961590
119MP0003136_yellow_coat_color0.65456193
120MP0002693_abnormal_pancreas_physiology0.65423722
121MP0005164_abnormal_response_to0.62438380
122MP0005645_abnormal_hypothalamus_physiol0.62211537
123MP0003866_abnormal_defecation0.59898217
124MP0002090_abnormal_vision0.59771904
125MP0003943_abnormal_hepatobiliary_system0.58647302
126MP0003828_pulmonary_edema0.58173889
127MP0002095_abnormal_skin_pigmentation0.57291448
128MP0005646_abnormal_pituitary_gland0.56806629
129MP0001188_hyperpigmentation0.56717919
130MP0005084_abnormal_gallbladder_morpholo0.55862478
131MP0004742_abnormal_vestibular_system0.55418783
132MP0000371_diluted_coat_color0.55254990
133MP0001851_eye_inflammation0.54526634
134MP0002396_abnormal_hematopoietic_system0.54267192
135MP0003453_abnormal_keratinocyte_physiol0.53561888
136MP0000703_abnormal_thymus_morphology0.53131109
137MP0001879_abnormal_lymphatic_vessel0.52566568

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.23230487
2Eczematoid dermatitis (HP:0000976)6.00814454
3Recurrent bacterial skin infections (HP:0005406)5.90268883
4Recurrent gram-negative bacterial infections (HP:0005420)4.59808983
5Increased IgM level (HP:0003496)4.56291578
6Abnormality of macrophages (HP:0004311)4.51609776
7Autoimmune thrombocytopenia (HP:0001973)4.07256193
8Optic neuritis (HP:0100653)4.06453930
9Retrobulbar optic neuritis (HP:0100654)4.06453930
10Vacuolated lymphocytes (HP:0001922)4.03084448
11Myositis (HP:0100614)3.83135456
12Elevated erythrocyte sedimentation rate (HP:0003565)3.79777323
13Orchitis (HP:0100796)3.79692963
14Recurrent fungal infections (HP:0002841)3.79664042
15Recurrent skin infections (HP:0001581)3.73814990
16Chronic otitis media (HP:0000389)3.68803233
17Systemic lupus erythematosus (HP:0002725)3.67400570
18Mediastinal lymphadenopathy (HP:0100721)3.66349900
19Gingivitis (HP:0000230)3.31038007
20Vasculitis (HP:0002633)3.21318494
21Asymmetric septal hypertrophy (HP:0001670)3.20014371
22Increased neuronal autofluorescent lipopigment (HP:0002074)3.18916752
23Recurrent viral infections (HP:0004429)3.15857885
24Loss of speech (HP:0002371)3.14396824
25Abnormality of polysaccharide metabolism (HP:0011012)3.13359891
26Abnormality of glycosaminoglycan metabolism (HP:0004371)3.13359891
27Abnormality of mucopolysaccharide metabolism (HP:0011020)3.13359891
28Chronic mucocutaneous candidiasis (HP:0002728)3.04935444
29Recurrent cutaneous fungal infections (HP:0011370)3.04935444
30Increased cerebral lipofuscin (HP:0011813)3.01948602
31Hypergammaglobulinemia (HP:0010702)3.01794890
32Basal ganglia calcification (HP:0002135)2.99055465
33Recurrent pneumonia (HP:0006532)2.91503724
34Chronic obstructive pulmonary disease (HP:0006510)2.89634202
35Obstructive lung disease (HP:0006536)2.89634202
36Axonal loss (HP:0003447)2.89297294
37Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.86628171
38Prostate neoplasm (HP:0100787)2.85712543
39Abnormality of liposaccharide metabolism (HP:0010968)2.82196353
40Abnormality of glycosphingolipid metabolism (HP:0004343)2.82196353
41Abnormality of glycolipid metabolism (HP:0010969)2.82196353
42Pulmonary infiltrates (HP:0002113)2.79217035
43Meningitis (HP:0001287)2.74797798
44Increased CSF protein (HP:0002922)2.68993168
45Periodontitis (HP:0000704)2.68936101
46Cellulitis (HP:0100658)2.68687406
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.66392059
48Eosinophilia (HP:0001880)2.66391637
49Agammaglobulinemia (HP:0004432)2.61467320
50Hematochezia (HP:0002573)2.60818125
51Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.56372578
52Hypothermia (HP:0002045)2.49126060
53Petechiae (HP:0000967)2.48328494
54Segmental peripheral demyelination/remyelination (HP:0003481)2.46150443
55Hepatosplenomegaly (HP:0001433)2.45630698
56Osteomyelitis (HP:0002754)2.45604190
57Abnormality of T cell number (HP:0011839)2.43275703
58Keratoconjunctivitis sicca (HP:0001097)2.43056666
59Prolonged neonatal jaundice (HP:0006579)2.41455775
60Gastrointestinal infarctions (HP:0005244)2.39144624
61Leukocytosis (HP:0001974)2.38264576
62Thick nail (HP:0001805)2.36058813
63Stomatitis (HP:0010280)2.31859674
64Interstitial pulmonary disease (HP:0006530)2.30651467
65Recurrent lower respiratory tract infections (HP:0002783)2.28809326
66Keratoconjunctivitis (HP:0001096)2.27907454
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.25369234
68Abnormality of eosinophils (HP:0001879)2.25267996
69Panhypogammaglobulinemia (HP:0003139)2.23091399
70Progressive visual loss (HP:0000529)2.20882043
71Autoimmune hemolytic anemia (HP:0001890)2.19159599
72Abnormality of the prostate (HP:0008775)2.18701763
73Granulocytopenia (HP:0001913)2.18138159
74Thyroiditis (HP:0100646)2.17949695
75Arterial thrombosis (HP:0004420)2.16727500
76Hemoptysis (HP:0002105)2.10660676
77Dysostosis multiplex (HP:0000943)2.09533469
78Neurofibrillary tangles (HP:0002185)2.09474903
79Joint hemorrhage (HP:0005261)2.09269443
80Ventricular fibrillation (HP:0001663)2.09010428
81Stomach cancer (HP:0012126)2.08256524
82Increased IgE level (HP:0003212)2.08071946
83Malnutrition (HP:0004395)2.06448666
84Urticaria (HP:0001025)2.06040495
85Spontaneous hematomas (HP:0007420)2.05746323
86Lip pit (HP:0100267)2.04019783
87Exercise-induced myalgia (HP:0003738)2.03195421
88Pulmonary embolism (HP:0002204)2.02509733
89Chest pain (HP:0100749)2.02159877
90Cheilitis (HP:0100825)2.01122058
91Gingival bleeding (HP:0000225)2.00591078
92Encephalitis (HP:0002383)1.99300728
93Colitis (HP:0002583)1.98109791
94Inflammation of the large intestine (HP:0002037)1.96976498
95Pustule (HP:0200039)1.93531837
96Sepsis (HP:0100806)1.91990809
97Hyporeflexia of lower limbs (HP:0002600)1.91962468
98Prolonged bleeding time (HP:0003010)1.90578214
99Recurrent bronchitis (HP:0002837)1.89360015
100Decreased circulating renin level (HP:0003351)1.89100654
101Chronic diarrhea (HP:0002028)1.87586515
102IgG deficiency (HP:0004315)1.87412667
103Alveolar cell carcinoma (HP:0006519)1.87317764
104Pigmentary retinal degeneration (HP:0001146)1.85628766
105Tetraparesis (HP:0002273)1.85134616
106T lymphocytopenia (HP:0005403)1.85014323
107Gastrointestinal inflammation (HP:0004386)1.84962024
108Gangrene (HP:0100758)1.84490054
109Premature loss of primary teeth (HP:0006323)1.83725893
110Urinary glycosaminoglycan excretion (HP:0003541)1.83466201
111Mucopolysacchariduria (HP:0008155)1.83466201
112Progressive neurologic deterioration (HP:0002344)1.82849264
113Patchy hypopigmentation of hair (HP:0011365)1.82477720
114Purpura (HP:0000979)1.82314159
115Acne (HP:0001061)1.81961963
116Joint swelling (HP:0001386)1.81798408
117Agnosia (HP:0010524)1.81709784
118Glomerulonephritis (HP:0000099)1.81689302
119IgM deficiency (HP:0002850)1.81434529
120Chronic sinusitis (HP:0011109)1.81030987
121Restrictive lung disease (HP:0002091)1.80318859
122Difficulty running (HP:0009046)1.79668085
123Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78345367
124Abnormality of the periventricular white matter (HP:0002518)1.77519981
125Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.77315818
126White forelock (HP:0002211)1.76640958
127Disinhibition (HP:0000734)1.76276659
128Bone pain (HP:0002653)1.76156227
129J-shaped sella turcica (HP:0002680)1.75971408
130Episodic fever (HP:0001954)1.74506624
131Amyloidosis (HP:0011034)1.72309368
132Vertigo (HP:0002321)1.71786093
133Abnormality of the endocardium (HP:0004306)1.71766253
134Abnormality of iron homeostasis (HP:0011031)1.68213674
135Increased serum ferritin (HP:0003281)1.66581158
136Polyneuropathy (HP:0001271)1.63360311
137Neuronal loss in central nervous system (HP:0002529)1.62679299
138Thin bony cortex (HP:0002753)1.61852345
139Hyperkalemia (HP:0002153)1.61238833
140Peripheral demyelination (HP:0011096)1.60638206

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.30571136
2IRAK43.43570274
3TYK23.04393355
4BMPR22.91246349
5IKBKE2.64206090
6TBK12.49577102
7PRPF4B2.48467406
8IKBKB2.48114361
9TXK2.46417785
10RIPK42.43258449
11MAP4K12.40130640
12ERN12.39234672
13BLK2.30071164
14TRIB32.27989007
15PIM22.07114666
16SIK32.01052543
17MST41.92889610
18JAK31.92397353
19SIK11.92050717
20JAK11.86097481
21CASK1.83698006
22CHUK1.77433609
23KIT1.73215761
24ADRBK21.65690977
25GRK61.59516928
26EPHB11.58418561
27MAP3K121.55428632
28TEC1.54968533
29MAP3K111.53169803
30NEK91.51186445
31PBK1.50232481
32RIPK11.48075208
33SYK1.45160171
34GRK71.42768482
35MAP3K131.42614285
36ERBB31.42595967
37CLK11.40623503
38IRAK31.39047063
39CDC42BPA1.35886660
40MAP2K31.35573646
41YES11.27548984
42MARK21.23484261
43BCR1.23032801
44BTK1.22934862
45MAP2K61.20641054
46MAP3K31.19380366
47TAOK11.18562829
48MAP3K11.17547397
49FGFR31.13338013
50ZAP701.13202778
51DAPK21.13015977
52MAP2K21.12135522
53PIM11.10325924
54ARAF1.09971535
55SGK21.05530415
56TRPM71.03917517
57IRAK11.02825436
58MAPK121.02598535
59TGFBR21.01875354
60NEK61.00942173
61MAP3K71.00592826
62ZAK0.99339140
63HCK0.98802468
64FER0.98656613
65BMPR1B0.98445952
66EPHA30.98065114
67PDPK10.96955571
68PDK10.96646697
69PRKD20.94865666
70TESK20.91436657
71CAMKK10.91094830
72INSRR0.90479884
73MATK0.86933890
74LYN0.83367558
75OBSCN0.82200237
76EIF2AK20.79625146
77LCK0.79558354
78CSK0.79352665
79ACVR1B0.78393316
80FGR0.78268166
81STK240.78245579
82NLK0.77932911
83CAMKK20.76489205
84MAP3K20.76427002
85PKN20.75428031
86SGK2230.75256649
87SGK4940.75256649
88PRKCD0.73213987
89ITK0.72826262
90SGK30.70398893
91PTK60.69937053
92MAP2K70.69712826
93FES0.69676715
94JAK20.69648507
95MAP2K40.67337857
96IRAK20.66252701
97PRKAA20.65806157
98CSF1R0.65009584
99MAPKAPK20.64123524
100PRKCQ0.64093166
101PRKCE0.61989875
102RET0.61368807
103RPS6KA60.61089154
104HIPK20.60765034
105CAMK1D0.60332008
106STK40.59204117
107DYRK1B0.58405460
108MAPK150.56536476
109TAOK30.55915515
110PKN10.54117291
111TNIK0.53815447
112MAP3K60.52854064
113FRK0.51751439
114FGFR40.51583953
115ABL20.50193358
116PRKD10.49182914
117RPS6KC10.48143705
118RPS6KL10.48143705
119SIK20.48015230
120PHKG20.46172102
121PHKG10.46172102
122GRK10.44898651
123STK110.43734295
124MARK30.43652543
125MAP2K10.42507994
126AKT30.40132392
127MAPKAPK50.38280137
128ABL10.37122843
129TNK20.32888043
130PRKCH0.32552490
131RPS6KB10.31272204
132RPS6KA50.31166188
133MOS0.30419044
134NUAK10.29619967
135RPS6KA20.28738926
136BMX0.26501020
137MAPK70.26385651
138PLK20.25352277
139PIK3CG0.23517837
140MAPK30.23239676
141TIE10.23193265
142GRK50.22846162

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.23200046
2Graft-versus-host disease_Homo sapiens_hsa053323.09691822
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.66479058
4Leishmaniasis_Homo sapiens_hsa051402.57422448
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.50701151
6Rheumatoid arthritis_Homo sapiens_hsa053232.47338125
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.47325387
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.38894374
9Measles_Homo sapiens_hsa051622.21621091
10Autoimmune thyroid disease_Homo sapiens_hsa053202.17765653
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01905566
12Osteoclast differentiation_Homo sapiens_hsa043802.00971518
13Type I diabetes mellitus_Homo sapiens_hsa049401.92113890
14Staphylococcus aureus infection_Homo sapiens_hsa051501.91876160
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91503142
16Pertussis_Homo sapiens_hsa051331.87382663
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80194646
18Tuberculosis_Homo sapiens_hsa051521.79358886
19Influenza A_Homo sapiens_hsa051641.76727312
20Lysosome_Homo sapiens_hsa041421.73986911
21SNARE interactions in vesicular transport_Homo sapiens_hsa041301.71626583
22Phagosome_Homo sapiens_hsa041451.66063309
23Primary immunodeficiency_Homo sapiens_hsa053401.65351496
24Asthma_Homo sapiens_hsa053101.63049348
25Legionellosis_Homo sapiens_hsa051341.59960945
26Malaria_Homo sapiens_hsa051441.57030909
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.53094908
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50673185
29Chemokine signaling pathway_Homo sapiens_hsa040621.48374035
30Collecting duct acid secretion_Homo sapiens_hsa049661.45837657
31Jak-STAT signaling pathway_Homo sapiens_hsa046301.45307791
32TNF signaling pathway_Homo sapiens_hsa046681.43239551
33Toxoplasmosis_Homo sapiens_hsa051451.40138371
34Other glycan degradation_Homo sapiens_hsa005111.38153282
35Salmonella infection_Homo sapiens_hsa051321.36870146
36Herpes simplex infection_Homo sapiens_hsa051681.36305776
37B cell receptor signaling pathway_Homo sapiens_hsa046621.35579105
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35372327
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34049960
40African trypanosomiasis_Homo sapiens_hsa051431.31158103
41Antigen processing and presentation_Homo sapiens_hsa046121.27004144
42Apoptosis_Homo sapiens_hsa042101.21061220
43Hematopoietic cell lineage_Homo sapiens_hsa046401.19944119
44Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19137430
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.13552916
46Shigellosis_Homo sapiens_hsa051311.10742746
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10053818
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08662605
49Viral myocarditis_Homo sapiens_hsa054161.07117933
50VEGF signaling pathway_Homo sapiens_hsa043700.99459730
51Insulin resistance_Homo sapiens_hsa049310.99275814
52Hepatitis C_Homo sapiens_hsa051600.99080604
53Adipocytokine signaling pathway_Homo sapiens_hsa049200.94676487
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.91681828
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88019956
56Hepatitis B_Homo sapiens_hsa051610.87223889
57Phototransduction_Homo sapiens_hsa047440.83746231
58Dorso-ventral axis formation_Homo sapiens_hsa043200.83103328
59T cell receptor signaling pathway_Homo sapiens_hsa046600.83034873
60Vibrio cholerae infection_Homo sapiens_hsa051100.81834178
61Prolactin signaling pathway_Homo sapiens_hsa049170.78869772
62PPAR signaling pathway_Homo sapiens_hsa033200.77149205
63GnRH signaling pathway_Homo sapiens_hsa049120.76594334
64Renin secretion_Homo sapiens_hsa049240.75170662
65Fatty acid biosynthesis_Homo sapiens_hsa000610.73953693
66Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73823106
67Non-small cell lung cancer_Homo sapiens_hsa052230.73482706
68mTOR signaling pathway_Homo sapiens_hsa041500.71528293
69Synaptic vesicle cycle_Homo sapiens_hsa047210.71250962
70Inositol phosphate metabolism_Homo sapiens_hsa005620.70641310
71Notch signaling pathway_Homo sapiens_hsa043300.70610000
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69681638
73Acute myeloid leukemia_Homo sapiens_hsa052210.68240487
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68174797
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.67897791
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.67582733
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65840736
78Renal cell carcinoma_Homo sapiens_hsa052110.65519677
79Insulin signaling pathway_Homo sapiens_hsa049100.64510123
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63193447
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61919045
82Ovarian steroidogenesis_Homo sapiens_hsa049130.61765160
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59522175
84Choline metabolism in cancer_Homo sapiens_hsa052310.59439915
85* ABC transporters_Homo sapiens_hsa020100.57347959
86FoxO signaling pathway_Homo sapiens_hsa040680.56341299
87Sphingolipid metabolism_Homo sapiens_hsa006000.56246626
88Amoebiasis_Homo sapiens_hsa051460.55369337
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55305089
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54880788
91Estrogen signaling pathway_Homo sapiens_hsa049150.54647253
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54259907
93Prion diseases_Homo sapiens_hsa050200.53302371
94Leukocyte transendothelial migration_Homo sapiens_hsa046700.53143886
95Protein export_Homo sapiens_hsa030600.49825444
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49142444
97Endometrial cancer_Homo sapiens_hsa052130.48850875
98Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48821112
99Platelet activation_Homo sapiens_hsa046110.48450377
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47649812
101AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47444437
102Olfactory transduction_Homo sapiens_hsa047400.46966338
103AMPK signaling pathway_Homo sapiens_hsa041520.45835155
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45610149
105Serotonergic synapse_Homo sapiens_hsa047260.45217691
106HIF-1 signaling pathway_Homo sapiens_hsa040660.44506626
107Linoleic acid metabolism_Homo sapiens_hsa005910.43895943
108Circadian rhythm_Homo sapiens_hsa047100.42992399
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42920121
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.40161620
111Morphine addiction_Homo sapiens_hsa050320.38362373
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37993954
113Arachidonic acid metabolism_Homo sapiens_hsa005900.37373018
114Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36852785
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.34866964
116Regulation of autophagy_Homo sapiens_hsa041400.34856645
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.34351720
118Epstein-Barr virus infection_Homo sapiens_hsa051690.32906753
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31778559
120Pancreatic cancer_Homo sapiens_hsa052120.30969952
121Mineral absorption_Homo sapiens_hsa049780.30551535
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28723778
123Ether lipid metabolism_Homo sapiens_hsa005650.27330486
124Cholinergic synapse_Homo sapiens_hsa047250.26341208
125MAPK signaling pathway_Homo sapiens_hsa040100.26186806
126Chronic myeloid leukemia_Homo sapiens_hsa052200.25208081
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.25113744
128Ras signaling pathway_Homo sapiens_hsa040140.24882015
129Type II diabetes mellitus_Homo sapiens_hsa049300.24808256
130Endocytosis_Homo sapiens_hsa041440.23875976
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22369041
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.22032602
133Thyroid cancer_Homo sapiens_hsa052160.21091948
134Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20950090

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