ABCG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1angiotensin maturation (GO:0002003)9.44238270
2regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)7.56100732
3epoxygenase P450 pathway (GO:0019373)7.06986162
4lipoprotein transport (GO:0042953)6.98670234
5regulation of guanylate cyclase activity (GO:0031282)6.31444651
6regulation of bile acid biosynthetic process (GO:0070857)6.18121161
7NADH metabolic process (GO:0006734)5.99169947
8* urate metabolic process (GO:0046415)5.97577863
9intestinal absorption (GO:0050892)5.95457159
10lysine metabolic process (GO:0006553)5.88007984
11lysine catabolic process (GO:0006554)5.88007984
12glyoxylate metabolic process (GO:0046487)5.77178569
13L-phenylalanine catabolic process (GO:0006559)5.76957820
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.76957820
15fat-soluble vitamin biosynthetic process (GO:0042362)5.72492627
16L-phenylalanine metabolic process (GO:0006558)5.70164216
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.70164216
18* drug transmembrane transport (GO:0006855)5.61146952
19cysteine metabolic process (GO:0006534)5.59577154
20aromatic amino acid family catabolic process (GO:0009074)5.49454745
21indolalkylamine catabolic process (GO:0046218)5.31953560
22tryptophan catabolic process (GO:0006569)5.31953560
23indole-containing compound catabolic process (GO:0042436)5.31953560
24uronic acid metabolic process (GO:0006063)5.14278387
25glucuronate metabolic process (GO:0019585)5.14278387
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.08023271
27very-low-density lipoprotein particle assembly (GO:0034379)5.05947802
28tryptophan metabolic process (GO:0006568)5.03840985
29positive regulation of guanylate cyclase activity (GO:0031284)5.02587154
30hormone catabolic process (GO:0042447)4.92147277
31alpha-linolenic acid metabolic process (GO:0036109)4.86979842
32* drug transport (GO:0015893)4.81696051
33kynurenine metabolic process (GO:0070189)4.75619918
34regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)4.69676299
35endocrine process (GO:0050886)4.69676299
36regulation of systemic arterial blood pressure by hormone (GO:0001990)4.69676299
37serine family amino acid catabolic process (GO:0009071)4.69407836
38homocysteine metabolic process (GO:0050667)4.61408241
39sulfur amino acid catabolic process (GO:0000098)4.53424456
40amino-acid betaine metabolic process (GO:0006577)4.42648803
41diacylglycerol metabolic process (GO:0046339)4.40380209
42bile acid biosynthetic process (GO:0006699)4.38339924
43plasma lipoprotein particle assembly (GO:0034377)4.33771264
44vitamin transmembrane transport (GO:0035461)4.31664501
45response to mercury ion (GO:0046689)4.30041508
46serine family amino acid metabolic process (GO:0009069)4.26342889
47drug catabolic process (GO:0042737)4.26067143
48protoporphyrinogen IX metabolic process (GO:0046501)4.22971157
49peptide hormone processing (GO:0016486)4.19683234
50short-chain fatty acid metabolic process (GO:0046459)4.17211865
51regulation of systemic arterial blood pressure (GO:0003073)4.16075743
52adhesion of symbiont to host cell (GO:0044650)4.16074867
53virion attachment to host cell (GO:0019062)4.16074867
54renal system process involved in regulation of blood volume (GO:0001977)4.11303101
55protoporphyrinogen IX biosynthetic process (GO:0006782)4.07076380
56vitamin transport (GO:0051180)4.06474850
57glycosphingolipid catabolic process (GO:0046479)3.98925675
58sulfate transmembrane transport (GO:1902358)3.98074030
59regulation of cGMP biosynthetic process (GO:0030826)3.97985195
60lipoprotein metabolic process (GO:0042157)3.96891202
61acetyl-CoA metabolic process (GO:0006084)3.96593242
62quaternary ammonium group transport (GO:0015697)3.96450980
63fatty acid beta-oxidation (GO:0006635)3.96036744
64protein-lipid complex assembly (GO:0065005)3.93692758
65glycolipid catabolic process (GO:0019377)3.92161724
66aromatic amino acid family metabolic process (GO:0009072)3.91865637
67midgut development (GO:0007494)3.91607102
68exogenous drug catabolic process (GO:0042738)3.91251491
69digestion (GO:0007586)3.90572120
70alpha-amino acid catabolic process (GO:1901606)3.89178364
71complement activation, alternative pathway (GO:0006957)3.88233547
72regulation of protein activation cascade (GO:2000257)3.87198210
73valine metabolic process (GO:0006573)3.86664431
74drinking behavior (GO:0042756)3.83138906
75ethanol oxidation (GO:0006069)3.82592021
76glycerol metabolic process (GO:0006071)3.76515996
77glycine metabolic process (GO:0006544)3.76421528
78regulation of complement activation (GO:0030449)3.75124406
79fatty acid oxidation (GO:0019395)3.74822092
80urea cycle (GO:0000050)3.74393894
81urea metabolic process (GO:0019627)3.74393894
82cellular amino acid catabolic process (GO:0009063)3.71397919
83aspartate family amino acid catabolic process (GO:0009068)3.70213623
84adhesion of symbiont to host (GO:0044406)3.68740029
85carnitine metabolic process (GO:0009437)3.68677022
86triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.66818737
87glutamine family amino acid biosynthetic process (GO:0009084)3.66737220
88bile acid metabolic process (GO:0008206)3.66672308
89serine family amino acid biosynthetic process (GO:0009070)3.65954167
90organic cation transport (GO:0015695)3.65834556
91aminoglycoside antibiotic metabolic process (GO:0030647)3.65618442
92lipid oxidation (GO:0034440)3.65480145
93cellular modified amino acid catabolic process (GO:0042219)3.63255899
94cellular biogenic amine catabolic process (GO:0042402)3.62598168
95amine catabolic process (GO:0009310)3.62598168
96phospholipid efflux (GO:0033700)3.62158654
97indolalkylamine metabolic process (GO:0006586)3.60584379
98citrulline biosynthetic process (GO:0019240)3.59271360
99fatty acid catabolic process (GO:0009062)3.58298348
100negative regulation of fibrinolysis (GO:0051918)3.58047660
101branched-chain amino acid metabolic process (GO:0009081)3.55791054
102response to nitrosative stress (GO:0051409)3.55180472
103bile acid and bile salt transport (GO:0015721)3.54690944
104omega-hydroxylase P450 pathway (GO:0097267)3.52922188
105L-ascorbic acid metabolic process (GO:0019852)3.52675097
106cellular response to nitric oxide (GO:0071732)3.51481627
107nitrogen cycle metabolic process (GO:0071941)3.50920788
108receptor guanylyl cyclase signaling pathway (GO:0007168)3.50690624
109cellular ketone body metabolic process (GO:0046950)3.48243785
110phosphate ion transport (GO:0006817)3.46813071
111phosphate ion transmembrane transport (GO:0035435)3.45342428
112regulation of cholesterol esterification (GO:0010872)3.44996650
113vitamin A metabolic process (GO:0006776)3.44918263
1142-oxoglutarate metabolic process (GO:0006103)3.43933867
115arginine metabolic process (GO:0006525)3.42816484
116aldehyde catabolic process (GO:0046185)3.42752588
117regulation of triglyceride catabolic process (GO:0010896)3.42001240
118triglyceride homeostasis (GO:0070328)3.41927845
119acylglycerol homeostasis (GO:0055090)3.41927845
120regulation of fibrinolysis (GO:0051917)3.41037006
121carboxylic acid catabolic process (GO:0046395)3.40398433
122organic acid catabolic process (GO:0016054)3.40398433
123fat-soluble vitamin metabolic process (GO:0006775)3.40384201
124alditol metabolic process (GO:0019400)3.39508295
125benzene-containing compound metabolic process (GO:0042537)3.37660334
126sulfate transport (GO:0008272)3.36270726
127ceramide catabolic process (GO:0046514)3.35116128
128cellular glucuronidation (GO:0052695)3.34823302
129nicotinamide nucleotide biosynthetic process (GO:0019359)3.34071888
130pyridine nucleotide biosynthetic process (GO:0019363)3.34071888
131regulation of cholesterol homeostasis (GO:2000188)3.34008878
132monocarboxylic acid catabolic process (GO:0072329)3.33531739
133glutamate metabolic process (GO:0006536)3.33423992
134tricarboxylic acid metabolic process (GO:0072350)3.32763030
135branched-chain amino acid catabolic process (GO:0009083)3.32334968
136amino-acid betaine transport (GO:0015838)3.32334967
137carnitine transport (GO:0015879)3.32334967
138regulation of protein glycosylation (GO:0060049)3.31965998
139regulation of cellular extravasation (GO:0002691)3.31499302
140glycosylceramide metabolic process (GO:0006677)3.30498536
141sulfur compound transport (GO:0072348)3.30333705
142vitamin D metabolic process (GO:0042359)3.30208881
143positive regulation of triglyceride lipase activity (GO:0061365)3.29215394
144positive regulation of lipoprotein lipase activity (GO:0051006)3.29215394
145flavonoid metabolic process (GO:0009812)3.28500537
146transcytosis (GO:0045056)3.25667925
147tyrosine metabolic process (GO:0006570)3.24899375
148neutral amino acid transport (GO:0015804)3.24713228
149cGMP-mediated signaling (GO:0019934)3.22947889
150regulation of cGMP metabolic process (GO:0030823)3.22499822
151high-density lipoprotein particle remodeling (GO:0034375)3.22229996
152protein carboxylation (GO:0018214)3.20924210
153peptidyl-glutamic acid carboxylation (GO:0017187)3.20924210
154drug metabolic process (GO:0017144)3.18782745
155sphingomyelin metabolic process (GO:0006684)3.18336523
156reverse cholesterol transport (GO:0043691)3.16793562
157positive regulation of glycoprotein biosynthetic process (GO:0010560)3.16621347
158cholesterol homeostasis (GO:0042632)3.15010999
159renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.14877034
160bundle of His cell to Purkinje myocyte communication (GO:0086069)3.11117379
161sterol homeostasis (GO:0055092)3.09558012
162positive regulation of lipid catabolic process (GO:0050996)3.08423359
163sphingolipid catabolic process (GO:0030149)3.07772220
164response to phenylpropanoid (GO:0080184)3.07597860
165fatty acid transmembrane transport (GO:1902001)3.07460673
166peptide catabolic process (GO:0043171)3.06617657
167cellular response to reactive nitrogen species (GO:1902170)3.06504043
168positive regulation of cGMP biosynthetic process (GO:0030828)3.06268978
169regulation of vitamin metabolic process (GO:0030656)3.05911718
170vitamin biosynthetic process (GO:0009110)3.04511985
171alkaloid metabolic process (GO:0009820)3.03441599
172fructose metabolic process (GO:0006000)3.03259824
173proline metabolic process (GO:0006560)3.02064682
174glycoside metabolic process (GO:0016137)3.01057223
175glycine transport (GO:0015816)2.98771540
176membrane lipid catabolic process (GO:0046466)2.95633589
177modified amino acid transport (GO:0072337)2.95595268
178cholesterol efflux (GO:0033344)2.94001780
179mRNA modification (GO:0016556)2.93130882
180macromolecular complex remodeling (GO:0034367)2.92830056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.13337117
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.28175705
3* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.60925593
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.47303815
5PPARA_22158963_ChIP-Seq_LIVER_Mouse5.47250596
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.84379248
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.78077039
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.24617173
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.02597052
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.77117738
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.71463853
12* HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.70079574
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59852183
14CLOCK_20551151_ChIP-Seq_293T_Human2.47153137
15STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.43048454
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.34548835
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.18891953
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.18889204
19GATA1_22025678_ChIP-Seq_K562_Human2.16001477
20AR_21909140_ChIP-Seq_LNCAP_Human2.00868847
21CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.99543923
22ESR1_21235772_ChIP-Seq_MCF-7_Human1.82157189
23TCF4_18268006_ChIP-ChIP_LS174T_Human1.80181357
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.73666362
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69702514
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64412607
27SCL_19346495_ChIP-Seq_HPC-7_Human1.64082516
28TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.62822455
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.60280666
30ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49857949
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46973428
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44685869
33TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41818872
34POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36710494
35E2F7_22180533_ChIP-Seq_HELA_Human1.36103640
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.35406351
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.34569126
38CDX2_22108803_ChIP-Seq_LS180_Human1.34368886
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.34326146
40GATA3_24758297_ChIP-Seq_MCF-7_Human1.33469332
41GATA4_25053715_ChIP-Seq_YYC3_Human1.32500938
42GATA1_19941826_ChIP-Seq_K562_Human1.28630286
43CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.26909463
44TRIM28_21343339_ChIP-Seq_HEK293_Human1.26703776
45FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.26151329
46KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.22886403
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.22217013
48SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20550538
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20227782
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.19758251
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.18398218
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.18056133
53AHR_22903824_ChIP-Seq_MCF-7_Human1.16479658
54TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15929343
55KLF5_25053715_ChIP-Seq_YYC3_Human1.15006753
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13838748
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.12855624
58RXR_22108803_ChIP-Seq_LS180_Human1.11393767
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09997502
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08630199
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06410820
62CDX2_20551321_ChIP-Seq_CACO-2_Human1.04770194
63RACK7_27058665_Chip-Seq_MCF-7_Human1.02415003
64FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01974051
65RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.01260481
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01003034
67RUNX1_27514584_Chip-Seq_MCF-7_Human1.00655138
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00654692
69* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.00608187
70TP63_17297297_ChIP-ChIP_HaCaT_Human0.99749574
71PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98560450
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.97920765
73SMAD3_21741376_ChIP-Seq_HESCs_Human0.97698356
74* TP63_23658742_ChIP-Seq_EP156T_Human0.97412296
75BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.96892333
76* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96481944
77GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95947596
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.95932413
79CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95552876
80* GATA1_19941827_ChIP-Seq_MEL_Mouse0.95046342
81HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94419673
82* SOX2_20726797_ChIP-Seq_SW620_Human0.93663553
83THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93349674
84* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92913067
85NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92002176
86ZNF263_19887448_ChIP-Seq_K562_Human0.91544919
87GATA2_19941826_ChIP-Seq_K562_Human0.91231109
88JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.89512112
89NELFA_20434984_ChIP-Seq_ESCs_Mouse0.88941437
90AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87996544
91* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87486364
92SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86362605
93* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.86270868
94SOX17_20123909_ChIP-Seq_XEN_Mouse0.85904897
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85683792
96P63_26484246_Chip-Seq_KERATINOCYTES_Human0.85485040
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.84446334
98GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83925659
99ESR2_21235772_ChIP-Seq_MCF-7_Human0.83835780
100TP53_18474530_ChIP-ChIP_U2OS_Human0.83330562
101TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82495653
102SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82319153
103* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81229042
104* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.79060465
105SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79005158
106LXR_22292898_ChIP-Seq_THP-1_Human0.78770931
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78122192
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77170153
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.77132442
110SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.77132442
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.76992665
112CBP_21632823_ChIP-Seq_H3396_Human0.76117601
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.74947304
114GATA6_25053715_ChIP-Seq_YYC3_Human0.74594968
115FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.74475817
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.73417338
117RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71910796
118MYC_18358816_ChIP-ChIP_MESCs_Mouse0.71179500
119IRF1_19129219_ChIP-ChIP_H3396_Human0.71137805
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71109436
121* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.70664689
122KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69712709
123* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.69528359
124CJUN_26792858_Chip-Seq_BT549_Human0.68840504
125* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.68674442
126OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.68661532
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.68506335
128* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.68168752
129FOXO3_23340844_ChIP-Seq_DLD1_Human0.68147537
130ARNT_22903824_ChIP-Seq_MCF-7_Human0.68009237
131* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.67373606
132AR_20517297_ChIP-Seq_VCAP_Human0.64753950
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.64530142
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.63773383
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.63232672
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.62299585
137CEBPB_22108803_ChIP-Seq_LS180_Human0.61466502
138FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60722194
139ZFX_18555785_ChIP-Seq_MESCs_Mouse0.60600040
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.60528243
141IRF8_22096565_ChIP-ChIP_GC-B_Human0.59740213
142PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.59151211
143* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.59129265
144PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.59089443
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.59082965
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.58980231
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.58339069
148SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56004538
149FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.55942679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis7.32028364
2MP0002139_abnormal_hepatobiliary_system6.08996251
3* MP0005085_abnormal_gallbladder_physiolo4.41796773
4MP0005365_abnormal_bile_salt4.26464287
5MP0003183_abnormal_peptide_metabolism4.19021317
6MP0003806_abnormal_nucleotide_metabolis3.73383816
7MP0008875_abnormal_xenobiotic_pharmacok3.46422684
8MP0004019_abnormal_vitamin_homeostasis3.13839355
9MP0003252_abnormal_bile_duct3.07110318
10MP0005332_abnormal_amino_acid2.98465310
11* MP0004147_increased_porphyrin_level2.89082447
12MP0005409_darkened_coat_color2.72274354
13MP0010368_abnormal_lymphatic_system2.43201596
14MP0010329_abnormal_lipoprotein_level2.40856524
15MP0002138_abnormal_hepatobiliary_system2.26196990
16MP0009643_abnormal_urine_homeostasis2.18685955
17MP0001666_abnormal_nutrient_absorption2.18237320
18MP0003656_abnormal_erythrocyte_physiolo2.12675828
19MP0001664_abnormal_digestion1.98041717
20MP0003879_abnormal_hair_cell1.96570746
21MP0005636_abnormal_mineral_homeostasis1.92020375
22MP0003186_abnormal_redox_activity1.83644568
23MP0003195_calcinosis1.81842122
24MP0003191_abnormal_cellular_cholesterol1.81744883
25MP0005083_abnormal_biliary_tract1.81291060
26MP0001879_abnormal_lymphatic_vessel1.80601225
27MP0005167_abnormal_blood-brain_barrier1.79721191
28MP0005319_abnormal_enzyme/_coenzyme1.76309634
29MP0010155_abnormal_intestine_physiology1.76279115
30MP0006054_spinal_hemorrhage1.72108816
31MP0009697_abnormal_copulation1.68567964
32MP0005084_abnormal_gallbladder_morpholo1.62089590
33MP0001756_abnormal_urination1.60671340
34MP0000609_abnormal_liver_physiology1.55656625
35MP0004270_analgesia1.54471810
36MP0003866_abnormal_defecation1.54152440
37MP0002118_abnormal_lipid_homeostasis1.52069714
38MP0009379_abnormal_foot_pigmentation1.51408476
39MP0004043_abnormal_pH_regulation1.49370570
40MP0005584_abnormal_enzyme/coenzyme_acti1.44090830
41MP0005670_abnormal_white_adipose1.40323999
42MP0002136_abnormal_kidney_physiology1.35236843
43MP0005166_decreased_susceptibility_to1.34702420
44MP0003724_increased_susceptibility_to1.30994737
45* MP0001764_abnormal_homeostasis1.30066765
46MP0009780_abnormal_chondrocyte_physiolo1.27164018
47MP0004272_abnormal_basement_membrane1.22817478
48MP0001765_abnormal_ion_homeostasis1.20976690
49MP0000598_abnormal_liver_morphology1.20817447
50MP0002098_abnormal_vibrissa_morphology1.12780564
51MP0001881_abnormal_mammary_gland1.12606704
52MP0006036_abnormal_mitochondrial_physio1.12215872
53MP0005408_hypopigmentation1.10821930
54MP0001501_abnormal_sleep_pattern1.10648078
55MP0009840_abnormal_foam_cell1.09194196
56MP0003868_abnormal_feces_composition1.08457622
57MP0005666_abnormal_adipose_tissue1.02913168
58MP0003300_gastrointestinal_ulcer1.02835804
59MP0003705_abnormal_hypodermis_morpholog1.01732732
60MP0005448_abnormal_energy_balance1.01217429
61MP0004782_abnormal_surfactant_physiolog1.01072994
62MP0000462_abnormal_digestive_system0.95876176
63MP0005535_abnormal_body_temperature0.95765964
64MP0008872_abnormal_physiological_respon0.95015673
65MP0009764_decreased_sensitivity_to0.94436948
66MP0004264_abnormal_extraembryonic_tissu0.94077403
67MP0009115_abnormal_fat_cell0.88290402
68MP0002009_preneoplasia0.84363558
69MP0003878_abnormal_ear_physiology0.83765399
70MP0005377_hearing/vestibular/ear_phenot0.83765399
71MP0000230_abnormal_systemic_arterial0.83385332
72MP0001958_emphysema0.81303753
73MP0009763_increased_sensitivity_to0.80073572
74MP0005647_abnormal_sex_gland0.79167551
75MP0003329_amyloid_beta_deposits0.78714120
76* MP0005376_homeostasis/metabolism_phenot0.77240343
77MP0003943_abnormal_hepatobiliary_system0.77220743
78MP0008260_abnormal_autophagy0.76561370
79MP0000538_abnormal_urinary_bladder0.76283895
80MP0008469_abnormal_protein_level0.75787415
81MP0003718_maternal_effect0.75331018
82MP0001542_abnormal_bone_strength0.74086045
83* MP0009642_abnormal_blood_homeostasis0.73039364
84MP0003011_delayed_dark_adaptation0.71906844
85MP0005397_hematopoietic_system_phenotyp0.70698270
86MP0001545_abnormal_hematopoietic_system0.70698270
87MP0005266_abnormal_metabolism0.68420814
88MP0002135_abnormal_kidney_morphology0.67400827
89MP0010352_gastrointestinal_tract_polyps0.67151477
90MP0002928_abnormal_bile_duct0.66353596
91MP0009053_abnormal_anal_canal0.63278847
92MP0009765_abnormal_xenobiotic_induced0.63227024
93MP0010678_abnormal_skin_adnexa0.63208150
94MP0005395_other_phenotype0.63144504
95MP0002796_impaired_skin_barrier0.61127377
96MP0004130_abnormal_muscle_cell0.60910356
97MP0003953_abnormal_hormone_level0.60269185
98MP0000537_abnormal_urethra_morphology0.60183119
99MP0004484_altered_response_of0.59979027
100MP0005165_increased_susceptibility_to0.59168651
101MP0003638_abnormal_response/metabolism_0.58133774
102MP0008775_abnormal_heart_ventricle0.57721664
103MP0001873_stomach_inflammation0.57668632
104MP0009384_cardiac_valve_regurgitation0.57645334
105MP0000604_amyloidosis0.56573542
106MP0005464_abnormal_platelet_physiology0.56083118
107MP0006138_congestive_heart_failure0.55198163
108MP0005058_abnormal_lysosome_morphology0.54158129
109MP0003045_fibrosis0.53970595
110MP0000249_abnormal_blood_vessel0.53239881
111MP0000013_abnormal_adipose_tissue0.53084513
112MP0001661_extended_life_span0.52949999
113MP0000678_abnormal_parathyroid_gland0.52773495
114MP0001188_hyperpigmentation0.52139281
115MP0002078_abnormal_glucose_homeostasis0.51284527
116MP0005330_cardiomyopathy0.51002739
117MP0001663_abnormal_digestive_system0.49965758
118MP0005164_abnormal_response_to0.49261112
119MP0005334_abnormal_fat_pad0.49139494
120MP0005451_abnormal_body_composition0.48770049
121MP0002822_catalepsy0.48583341
122MP0010307_abnormal_tumor_latency0.48146144
123MP0008004_abnormal_stomach_pH0.47527552
124MP0000767_abnormal_smooth_muscle0.46657657
125MP0003075_altered_response_to0.46563715
126MP0002128_abnormal_blood_circulation0.46537088
127MP0010234_abnormal_vibrissa_follicle0.45319728
128MP0000477_abnormal_intestine_morphology0.44883993
129MP0002971_abnormal_brown_adipose0.44687029
130* MP0005501_abnormal_skin_physiology0.44444713
131MP0005220_abnormal_exocrine_pancreas0.44138028
132MP0001485_abnormal_pinna_reflex0.43144822
133MP0008874_decreased_physiological_sensi0.43058288
134MP0000377_abnormal_hair_follicle0.42787836
135MP0002876_abnormal_thyroid_physiology0.42386815
136MP0000490_abnormal_crypts_of0.42117190
137MP0002166_altered_tumor_susceptibility0.41875870
138MP0005381_digestive/alimentary_phenotyp0.41577054
139MP0002896_abnormal_bone_mineralization0.41281463
140MP0002086_abnormal_extraembryonic_tissu0.41196116
141MP0002837_dystrophic_cardiac_calcinosis0.41096435
142MP0002168_other_aberrant_phenotype0.40712612
143MP0005595_abnormal_vascular_smooth0.40439088

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)5.20115027
2Hyperglycinuria (HP:0003108)4.62076360
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.52579075
4Chronic diarrhea (HP:0002028)4.48067715
5Abnormality of glutamine family amino acid metabolism (HP:0010902)4.46657915
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.35929265
7Abnormality of the vitamin B12 metabolism (HP:0004341)4.29551551
8Abnormality of vitamin B metabolism (HP:0004340)4.19804999
9Widely patent fontanelles and sutures (HP:0004492)4.19778978
10Abnormality of the heme biosynthetic pathway (HP:0010472)4.11269986
11Xanthomatosis (HP:0000991)4.08371341
12Abnormality of glycine metabolism (HP:0010895)4.04603683
13Abnormality of serine family amino acid metabolism (HP:0010894)4.04603683
14Gout (HP:0001997)3.99905448
15Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95215978
16Abnormality of purine metabolism (HP:0004352)3.94538202
17Deep venous thrombosis (HP:0002625)3.94382465
18Proximal tubulopathy (HP:0000114)3.90508983
19Hyperammonemia (HP:0001987)3.87257741
20Hyperglycinemia (HP:0002154)3.81722685
21Hypoglycemic coma (HP:0001325)3.77941404
22Hypobetalipoproteinemia (HP:0003563)3.76542131
23Abnormality of vitamin metabolism (HP:0100508)3.72636087
24Abnormality of nucleobase metabolism (HP:0010932)3.58368358
25Generalized aminoaciduria (HP:0002909)3.57010502
26Pigmentary retinal degeneration (HP:0001146)3.49698330
27Complement deficiency (HP:0004431)3.48701304
28Ketosis (HP:0001946)3.48215562
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.48178618
30Prolonged partial thromboplastin time (HP:0003645)3.44756836
31Hyperbilirubinemia (HP:0002904)3.37748202
32Abnormality of fatty-acid metabolism (HP:0004359)3.33984005
33Abdominal distention (HP:0003270)3.32287940
34Malnutrition (HP:0004395)3.26750039
35Increased purine levels (HP:0004368)3.17944601
36Hyperuricemia (HP:0002149)3.17944601
37Papilledema (HP:0001085)3.13582785
38Megaloblastic anemia (HP:0001889)3.11033236
39Decreased circulating renin level (HP:0003351)3.10070495
40Nausea (HP:0002018)3.09743085
41Fat malabsorption (HP:0002630)3.05953187
42Facial shape deformation (HP:0011334)3.03710043
43Potter facies (HP:0002009)3.03710043
44Wide cranial sutures (HP:0010537)3.02930299
45Ketoacidosis (HP:0001993)3.00987611
46Delayed CNS myelination (HP:0002188)3.00290090
47Hepatocellular carcinoma (HP:0001402)2.98328218
48Abnormality of renin-angiotensin system (HP:0000847)2.92682851
49Dicarboxylic aciduria (HP:0003215)2.90275587
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.90275587
51Acanthocytosis (HP:0001927)2.89685559
52Congenital sensorineural hearing impairment (HP:0008527)2.89602716
53Hypokalemic alkalosis (HP:0001949)2.88292978
54Glycosuria (HP:0003076)2.87913523
55Abnormality of urine glucose concentration (HP:0011016)2.87913523
56Poikilocytosis (HP:0004447)2.87419898
57Alkalosis (HP:0001948)2.86274699
58Abnormality of pyrimidine metabolism (HP:0004353)2.86028669
59Hypolipoproteinemia (HP:0010981)2.84321629
60Metabolic alkalosis (HP:0200114)2.84230091
61Thin bony cortex (HP:0002753)2.83844304
62Joint hemorrhage (HP:0005261)2.82506766
63Hypochromic microcytic anemia (HP:0004840)2.81566636
64Abnormality of serum amino acid levels (HP:0003112)2.79676758
65Right ventricular cardiomyopathy (HP:0011663)2.79380750
66Hyperactive renin-angiotensin system (HP:0000841)2.79147829
67Metabolic acidosis (HP:0001942)2.79036210
68Facial diplegia (HP:0001349)2.77804711
69Hyperlipoproteinemia (HP:0010980)2.76634502
70Increased circulating renin level (HP:0000848)2.74233367
71Abnormality of the intrinsic pathway (HP:0010989)2.71955528
72Abnormal urine output (HP:0012590)2.71620351
73Ileus (HP:0002595)2.70802668
74Polyuria (HP:0000103)2.70131715
75Posterior subcapsular cataract (HP:0007787)2.69198999
76Hypomagnesemia (HP:0002917)2.68784385
77Spastic diplegia (HP:0001264)2.68673139
78Abnormality of renal excretion (HP:0011036)2.67236190
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.66734121
80Abnormality of methionine metabolism (HP:0010901)2.62329667
81Confusion (HP:0001289)2.60184656
82Lethargy (HP:0001254)2.55030263
83Subcapsular cataract (HP:0000523)2.52486424
84Esophageal varix (HP:0002040)2.48956261
85Abnormality of chloride homeostasis (HP:0011422)2.47492069
86Abnormal urine phosphate concentration (HP:0012599)2.47481525
87Abnormality of the common coagulation pathway (HP:0010990)2.47241618
88Focal segmental glomerulosclerosis (HP:0000097)2.46424720
89Systemic lupus erythematosus (HP:0002725)2.45463611
90Hyperparathyroidism (HP:0000843)2.45233838
91Vomiting (HP:0002013)2.44459741
92Abnormal enzyme/coenzyme activity (HP:0012379)2.43667835
93Abnormality of magnesium homeostasis (HP:0004921)2.42947010
94Hypophosphatemia (HP:0002148)2.42675525
95Rickets (HP:0002748)2.42474856
96Renal tubular dysfunction (HP:0000124)2.41803240
97Abnormality of complement system (HP:0005339)2.37960979
98Vascular calcification (HP:0004934)2.37448942
99Epidermoid cyst (HP:0200040)2.37288872
100Cholelithiasis (HP:0001081)2.37028516
101Hypoalphalipoproteinemia (HP:0003233)2.36156162
102Abnormality of proline metabolism (HP:0010907)2.35675462
103Hydroxyprolinuria (HP:0003080)2.35675462
104Aortic aneurysm (HP:0004942)2.34823616
105Irritability (HP:0000737)2.33852375
106Steatorrhea (HP:0002570)2.31490098
107Enlarged kidneys (HP:0000105)2.28338789
108Polycythemia (HP:0001901)2.26998285
109Abnormality of alkaline phosphatase activity (HP:0004379)2.25948836
110Nephrolithiasis (HP:0000787)2.24802534
111Flat acetabular roof (HP:0003180)2.23585558
112Abnormal gallbladder morphology (HP:0012437)2.20381438
113Conjugated hyperbilirubinemia (HP:0002908)2.19616073
114Elevated alkaline phosphatase (HP:0003155)2.19553991
115Hypoglycemic seizures (HP:0002173)2.19498558
116Cardiovascular calcification (HP:0011915)2.18995184
117Enlarged epiphyses (HP:0010580)2.15005365
118Sensorimotor neuropathy (HP:0007141)2.14459049
119Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14175603
120Reticulocytosis (HP:0001923)2.11085800
121Hypotension (HP:0002615)2.09175195
122Hypercholesterolemia (HP:0003124)2.08464240
123Abnormality of transition element cation homeostasis (HP:0011030)2.08060086
124Renal tubular acidosis (HP:0001947)2.06790859
125Symptomatic seizures (HP:0011145)2.06726457
126Hyperaldosteronism (HP:0000859)2.06497631
127Pancreatitis (HP:0001733)2.05644264
128Hyperphosphaturia (HP:0003109)2.02736881
129Nonimmune hydrops fetalis (HP:0001790)2.00018068
130Abnormality of iron homeostasis (HP:0011031)1.97994622
131Delayed epiphyseal ossification (HP:0002663)1.95032527
132Abnormality of the costochondral junction (HP:0000919)1.93300937
133Ankle clonus (HP:0011448)1.92309891
134Growth hormone excess (HP:0000845)1.92052212
135Abnormal glucose tolerance (HP:0001952)1.91830285
136Hypokalemia (HP:0002900)1.91472242
137Villous atrophy (HP:0011473)1.90644159
138Abnormality of small intestinal villus morphology (HP:0011472)1.90644159
139Glomerulosclerosis (HP:0000096)1.88430180
140Protuberant abdomen (HP:0001538)1.86579151
141Cerebral palsy (HP:0100021)1.83198978
142Curly hair (HP:0002212)1.82610428
143Skin nodule (HP:0200036)1.82326672
144Hemorrhage of the eye (HP:0011885)1.81401019
145Multiple lipomas (HP:0001012)1.80246046
146Abnormality of the periventricular white matter (HP:0002518)1.77311388
147Osteomalacia (HP:0002749)1.77013632
148Abnormal biliary tract morphology (HP:0012440)1.75345989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.27278479
2MYLK4.37744893
3BCKDK4.06007109
4KDR3.90452776
5WNK43.09414352
6TGFBR22.81650693
7WNK32.52154452
8OXSR12.43675999
9MAP3K22.13544936
10LATS22.12309764
11EIF2AK12.06151879
12TSSK62.04459066
13TGFBR12.02699050
14MAP3K122.02592076
15EPHA42.01618241
16PIK3CG1.97816573
17PDK21.96998120
18NME21.84887544
19FLT31.79839714
20PDK41.79213908
21PDK31.79213908
22STK38L1.71170657
23MAP3K101.67957087
24MAP2K31.65034495
25BMPR21.61362351
26PKN21.58500662
27MST1R1.55092943
28SIK11.54067570
29INSRR1.51803017
30NEK61.51338795
31FRK1.43454226
32GRK11.43266759
33NEK11.41993988
34PIK3CA1.38907056
35PBK1.36835357
36FGFR41.29332802
37PDPK11.19042728
38MET1.18184684
39MAPK111.17913281
40PAK21.17311451
41ERN11.16693854
42MAP3K31.13496155
43NEK91.12849055
44PRKAA21.12003337
45RIPK11.07285574
46NUAK11.04091345
47ERBB41.02123800
48CAMK1D1.00079173
49BMPR1B0.99657774
50ACVR1B0.97363978
51STK240.96703734
52PTK60.95250815
53PRKG20.94627400
54MAPKAPK30.93967296
55STK390.93800001
56ZAK0.93586749
57TTN0.89592931
58GSK3A0.88997118
59PRPF4B0.87305952
60DAPK20.85606402
61LRRK20.82398594
62CAMK2G0.81489015
63CAMK2D0.81091934
64LATS10.78301029
65PTK2B0.76042574
66CDK60.75741184
67MELK0.72097806
68TESK20.71816349
69EPHB20.69660927
70MATK0.69443529
71ABL20.69422602
72STK380.68673293
73CAMK2B0.68310149
74DDR20.68002395
75FGFR30.67401319
76MAP3K10.67271423
77LMTK20.67063324
78TBK10.66920267
79KSR20.66433486
80STK100.66299661
81PAK40.64303092
82NTRK30.63671275
83MAPK120.61226191
84WEE10.56991742
85TTK0.55645204
86PDK10.55337285
87TESK10.53246088
88STK30.52998761
89MAPK40.51938355
90TNIK0.50304500
91ICK0.49026575
92PINK10.48360324
93RPS6KB20.48131594
94IRAK30.48076135
95SCYL20.47246375
96PTK20.46518361
97AURKB0.45784916
98PRKCA0.45545826
99MAP3K80.45501264
100JAK20.44789201
101ERBB20.44036321
102BMX0.43874656
103PRKAA10.43756987
104AKT30.43723649
105TEC0.43588868
106DAPK10.43442237
107GRK60.43372751
108MAP3K70.42757229
109NLK0.41204662
110CASK0.40512665
111IGF1R0.39432854
112STK40.38577999
113MAP3K140.38542299
114MAP3K110.37041909
115PDGFRA0.36537649
116BRSK20.36002586
117EIF2AK20.35915231
118CDK40.35842372
119MAPK150.33310759
120MAP2K10.32683088
121TYK20.32394618
122MST40.31867149
123EPHA20.31100545
124JAK30.31064031
125FER0.30662240
126AKT20.30167627
127PRKCZ0.28836241
128MAPKAPK50.28630345
129PRKCD0.28301907
130MAP2K60.27231353
131SRC0.26642673
132IKBKE0.26365072
133VRK10.26022224
134EIF2AK30.25547575
135MUSK0.24771392
136MAP2K20.24660242
137IRAK20.24534254
138PRKCI0.24274568
139RPS6KB10.24012924
140DAPK30.23926611
141EEF2K0.23664154
142PRKACG0.23606554
143SGK2230.23297287
144CAMK2A0.22839511
145PRKD30.21987225
146RET0.21556819
147TYRO30.18567617
148GRK50.16637190
149PRKD10.15079460
150PHKG20.14021897

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.31877455
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16199406
3Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.92509027
4Fatty acid degradation_Homo sapiens_hsa000712.74910888
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.67283765
6Propanoate metabolism_Homo sapiens_hsa006402.61656122
7Tryptophan metabolism_Homo sapiens_hsa003802.55568809
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52973779
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.49790009
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.28057903
11Peroxisome_Homo sapiens_hsa041462.27937219
12Arginine biosynthesis_Homo sapiens_hsa002202.27189782
13Butanoate metabolism_Homo sapiens_hsa006502.25285384
14Nitrogen metabolism_Homo sapiens_hsa009102.23543238
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.12933352
16Pyruvate metabolism_Homo sapiens_hsa006202.07181306
17Fatty acid metabolism_Homo sapiens_hsa012122.07098946
18Caffeine metabolism_Homo sapiens_hsa002322.03805445
19PPAR signaling pathway_Homo sapiens_hsa033202.01394415
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99454596
21Complement and coagulation cascades_Homo sapiens_hsa046101.95707998
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93995760
23Vitamin digestion and absorption_Homo sapiens_hsa049771.88486236
24Carbohydrate digestion and absorption_Homo sapiens_hsa049731.84034443
25Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.79044403
26Selenocompound metabolism_Homo sapiens_hsa004501.75314285
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69828899
28Cyanoamino acid metabolism_Homo sapiens_hsa004601.69520241
29beta-Alanine metabolism_Homo sapiens_hsa004101.69233029
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62593867
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.58756089
32Chemical carcinogenesis_Homo sapiens_hsa052041.53743454
33Linoleic acid metabolism_Homo sapiens_hsa005911.53237253
34Folate biosynthesis_Homo sapiens_hsa007901.51195467
35Carbon metabolism_Homo sapiens_hsa012001.49079687
36* Bile secretion_Homo sapiens_hsa049761.49016800
37Histidine metabolism_Homo sapiens_hsa003401.47720005
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46068044
39Steroid hormone biosynthesis_Homo sapiens_hsa001401.42187438
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.39309959
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37443754
42Sulfur metabolism_Homo sapiens_hsa009201.37056080
43Glutathione metabolism_Homo sapiens_hsa004801.27639210
44Fatty acid elongation_Homo sapiens_hsa000621.25709829
45Arginine and proline metabolism_Homo sapiens_hsa003301.23990462
46Retinol metabolism_Homo sapiens_hsa008301.23021355
47Starch and sucrose metabolism_Homo sapiens_hsa005001.20340473
48Biosynthesis of amino acids_Homo sapiens_hsa012301.19120545
49Sulfur relay system_Homo sapiens_hsa041221.16949206
50Phenylalanine metabolism_Homo sapiens_hsa003601.14290162
51Fat digestion and absorption_Homo sapiens_hsa049751.12831996
52Sphingolipid metabolism_Homo sapiens_hsa006001.12088127
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09021970
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07224320
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06758474
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.05293230
57One carbon pool by folate_Homo sapiens_hsa006701.02825214
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02427868
59Fatty acid biosynthesis_Homo sapiens_hsa000610.99742508
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97913674
61Tyrosine metabolism_Homo sapiens_hsa003500.94254635
62Vitamin B6 metabolism_Homo sapiens_hsa007500.88464360
63Staphylococcus aureus infection_Homo sapiens_hsa051500.86854415
64* ABC transporters_Homo sapiens_hsa020100.84835897
65Lysine degradation_Homo sapiens_hsa003100.79502806
66Ether lipid metabolism_Homo sapiens_hsa005650.78526478
67Pentose phosphate pathway_Homo sapiens_hsa000300.77623531
68Glycerolipid metabolism_Homo sapiens_hsa005610.75469505
69Steroid biosynthesis_Homo sapiens_hsa001000.74599353
70Galactose metabolism_Homo sapiens_hsa000520.72565526
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70035699
72Fructose and mannose metabolism_Homo sapiens_hsa000510.65290541
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.64174246
74Metabolic pathways_Homo sapiens_hsa011000.62303833
75Pancreatic secretion_Homo sapiens_hsa049720.60052308
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55672411
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48495967
78Mineral absorption_Homo sapiens_hsa049780.48155848
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.47846506
80Protein digestion and absorption_Homo sapiens_hsa049740.47752841
81Systemic lupus erythematosus_Homo sapiens_hsa053220.39483914
82Renin secretion_Homo sapiens_hsa049240.37794812
83Arachidonic acid metabolism_Homo sapiens_hsa005900.35405480
84Thyroid hormone synthesis_Homo sapiens_hsa049180.32587676
85Insulin secretion_Homo sapiens_hsa049110.30623079
86Tight junction_Homo sapiens_hsa045300.29980380
87Ribosome_Homo sapiens_hsa030100.29630853
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26392856
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25232128
90Renin-angiotensin system_Homo sapiens_hsa046140.23118785
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22862491
92DNA replication_Homo sapiens_hsa030300.18895247
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18223970
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.17982313
95Pyrimidine metabolism_Homo sapiens_hsa002400.16339251
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15434145
97Insulin resistance_Homo sapiens_hsa049310.14725545
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13978624
99Serotonergic synapse_Homo sapiens_hsa047260.13955470
100Amphetamine addiction_Homo sapiens_hsa050310.13939942
101Dorso-ventral axis formation_Homo sapiens_hsa043200.13457179
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.13297653
103GnRH signaling pathway_Homo sapiens_hsa049120.09759146
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.08906256
105ECM-receptor interaction_Homo sapiens_hsa045120.08820625
106Cocaine addiction_Homo sapiens_hsa050300.08486168
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07651941
108AMPK signaling pathway_Homo sapiens_hsa041520.07647924
109Inositol phosphate metabolism_Homo sapiens_hsa005620.07449689
110Estrogen signaling pathway_Homo sapiens_hsa049150.07239282
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06875358
112African trypanosomiasis_Homo sapiens_hsa051430.06774984
113N-Glycan biosynthesis_Homo sapiens_hsa005100.06339560
114Other glycan degradation_Homo sapiens_hsa005110.04753896
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.04254212
116Proteasome_Homo sapiens_hsa030500.03332146
117Thyroid cancer_Homo sapiens_hsa052160.02250750
118Adherens junction_Homo sapiens_hsa045200.01868472
119Gastric acid secretion_Homo sapiens_hsa049710.01857539
120Hepatitis C_Homo sapiens_hsa051600.01159671
121Prion diseases_Homo sapiens_hsa05020-0.0535939
122Glucagon signaling pathway_Homo sapiens_hsa04922-0.0375450
123Purine metabolism_Homo sapiens_hsa00230-0.0373716
124Malaria_Homo sapiens_hsa05144-0.0322188
125Mismatch repair_Homo sapiens_hsa03430-0.0307207
126Bladder cancer_Homo sapiens_hsa05219-0.0094395
127Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0062973

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