ABCG5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The protein encoded by this gene functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. It is expressed in a tissue-specific manner in the liver, colon, and intestine. This gene is tandemly arrayed on chromosome 2, in a head-to-head orientation with family member ABCG8. Mutations in this gene may contribute to sterol accumulation and atheroschlerosis, and have been observed in patients with sitosterolemia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.30523418
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.30523418
3L-phenylalanine metabolic process (GO:0006558)6.98994053
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.98994053
5omega-hydroxylase P450 pathway (GO:0097267)6.84861107
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.75099255
7aromatic amino acid family catabolic process (GO:0009074)6.54826982
8indole-containing compound catabolic process (GO:0042436)5.89782205
9indolalkylamine catabolic process (GO:0046218)5.89782205
10tryptophan catabolic process (GO:0006569)5.89782205
11kynurenine metabolic process (GO:0070189)5.78990817
12high-density lipoprotein particle remodeling (GO:0034375)5.72207625
13urea metabolic process (GO:0019627)5.68310509
14urea cycle (GO:0000050)5.68310509
15bile acid biosynthetic process (GO:0006699)5.67439295
16alpha-linolenic acid metabolic process (GO:0036109)5.57076738
17tryptophan metabolic process (GO:0006568)5.55952871
18glyoxylate metabolic process (GO:0046487)5.48441020
19regulation of cholesterol esterification (GO:0010872)5.28477284
20negative regulation of fibrinolysis (GO:0051918)5.27606918
21cysteine metabolic process (GO:0006534)5.23030479
22nitrogen cycle metabolic process (GO:0071941)5.21430724
23oxidative demethylation (GO:0070989)5.18166919
24regulation of plasminogen activation (GO:0010755)5.17038017
25regulation of triglyceride catabolic process (GO:0010896)5.16612091
26regulation of fibrinolysis (GO:0051917)5.11221166
27protein carboxylation (GO:0018214)5.10669048
28peptidyl-glutamic acid carboxylation (GO:0017187)5.10669048
29sulfur amino acid catabolic process (GO:0000098)5.08547807
30reverse cholesterol transport (GO:0043691)5.06069572
31phospholipid efflux (GO:0033700)5.01321744
32complement activation, alternative pathway (GO:0006957)4.99380937
33regulation of protein activation cascade (GO:2000257)4.98342209
34bile acid metabolic process (GO:0008206)4.97228904
35protein-lipid complex remodeling (GO:0034368)4.93298978
36macromolecular complex remodeling (GO:0034367)4.93298978
37plasma lipoprotein particle remodeling (GO:0034369)4.93298978
38serine family amino acid catabolic process (GO:0009071)4.87918057
39fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.82606858
40aromatic amino acid family metabolic process (GO:0009072)4.75516927
41homocysteine metabolic process (GO:0050667)4.71491197
42triglyceride homeostasis (GO:0070328)4.70222050
43acylglycerol homeostasis (GO:0055090)4.70222050
44regulation of complement activation (GO:0030449)4.64683610
45ethanol metabolic process (GO:0006067)4.61974714
46tyrosine metabolic process (GO:0006570)4.61686380
47protein activation cascade (GO:0072376)4.60714778
48negative regulation of protein activation cascade (GO:2000258)4.56351129
49negative regulation of blood coagulation (GO:0030195)4.55055896
50negative regulation of hemostasis (GO:1900047)4.55055896
51drug catabolic process (GO:0042737)4.53221974
52amino-acid betaine metabolic process (GO:0006577)4.52173760
53bile acid and bile salt transport (GO:0015721)4.52053810
54lysine catabolic process (GO:0006554)4.48494608
55lysine metabolic process (GO:0006553)4.48494608
56alpha-amino acid catabolic process (GO:1901606)4.45875661
57* negative regulation of cholesterol transport (GO:0032375)4.45340287
58* negative regulation of sterol transport (GO:0032372)4.45340287
59plasma lipoprotein particle clearance (GO:0034381)4.40324856
60plasma lipoprotein particle assembly (GO:0034377)4.39910817
61cellular glucuronidation (GO:0052695)4.37036401
62* cholesterol efflux (GO:0033344)4.35818146
63phenylpropanoid metabolic process (GO:0009698)4.35557261
64cellular ketone body metabolic process (GO:0046950)4.30050437
65complement activation, classical pathway (GO:0006958)4.23878621
66positive regulation of lipoprotein lipase activity (GO:0051006)4.19482777
67positive regulation of triglyceride lipase activity (GO:0061365)4.19482777
68regulation of humoral immune response (GO:0002920)4.19147689
69coenzyme catabolic process (GO:0009109)4.18531158
70indolalkylamine metabolic process (GO:0006586)4.18148091
71acute-phase response (GO:0006953)4.17758442
72glutamate metabolic process (GO:0006536)4.16477493
73negative regulation of coagulation (GO:0050819)4.16337627
74glycine metabolic process (GO:0006544)4.16257702
75imidazole-containing compound metabolic process (GO:0052803)4.15586534
76regulation of bile acid biosynthetic process (GO:0070857)4.14282373
77very-low-density lipoprotein particle assembly (GO:0034379)4.12293823
78cellular amino acid catabolic process (GO:0009063)4.09926568
79complement activation (GO:0006956)4.09672194
80amine catabolic process (GO:0009310)4.07298736
81cellular biogenic amine catabolic process (GO:0042402)4.07298736
82S-adenosylmethionine metabolic process (GO:0046500)4.03944445
83negative regulation of wound healing (GO:0061045)4.03749967
84positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.03347015
85benzene-containing compound metabolic process (GO:0042537)4.01218633
86serine family amino acid metabolic process (GO:0009069)3.99307250
87flavonoid metabolic process (GO:0009812)3.99171655
88arginine metabolic process (GO:0006525)3.97622127
89low-density lipoprotein particle remodeling (GO:0034374)3.97163076
90protein-lipid complex assembly (GO:0065005)3.96687099
91positive regulation of blood coagulation (GO:0030194)3.95655594
92positive regulation of hemostasis (GO:1900048)3.95655594
93cellular modified amino acid catabolic process (GO:0042219)3.93905176
94positive regulation of lipid catabolic process (GO:0050996)3.93453383
95ethanol oxidation (GO:0006069)3.93030081
96* cholesterol homeostasis (GO:0042632)3.90612360
97serine family amino acid biosynthetic process (GO:0009070)3.88316608
98glucuronate metabolic process (GO:0019585)3.87781983
99uronic acid metabolic process (GO:0006063)3.87781983
100dicarboxylic acid biosynthetic process (GO:0043650)3.85844223
101* sterol homeostasis (GO:0055092)3.84206723
102plasma lipoprotein particle organization (GO:0071827)3.82731014
103phospholipid homeostasis (GO:0055091)3.81096504
104regulation of cholesterol homeostasis (GO:2000188)3.79363535
105* intestinal cholesterol absorption (GO:0030299)3.78332049
106fibrinolysis (GO:0042730)3.77571300
107aldehyde catabolic process (GO:0046185)3.77314268
108lipoprotein metabolic process (GO:0042157)3.76500958
109negative regulation of lipase activity (GO:0060192)3.73172359
110alkaloid metabolic process (GO:0009820)3.73132380
111negative regulation of complement activation (GO:0045916)3.71957925
112ketone body metabolic process (GO:1902224)3.71735926
113exogenous drug catabolic process (GO:0042738)3.71715860
114fat-soluble vitamin biosynthetic process (GO:0042362)3.70079352
115cytolysis (GO:0019835)3.66592686
116drug metabolic process (GO:0017144)3.65438170
117regulation of apoptotic cell clearance (GO:2000425)3.63254454
118positive regulation of coagulation (GO:0050820)3.62438998
119organic acid catabolic process (GO:0016054)3.62334201
120carboxylic acid catabolic process (GO:0046395)3.62334201
121cofactor catabolic process (GO:0051187)3.61471793
122protein-lipid complex subunit organization (GO:0071825)3.61322390
123proline metabolic process (GO:0006560)3.61021526
124blood coagulation, intrinsic pathway (GO:0007597)3.60046018
125heme transport (GO:0015886)3.58990833
126short-chain fatty acid metabolic process (GO:0046459)3.55957072
127epoxygenase P450 pathway (GO:0019373)3.54349787
128drug transmembrane transport (GO:0006855)3.52930008

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse8.27706251
2PPARA_22158963_ChIP-Seq_LIVER_Mouse7.14595154
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.86482389
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.46006368
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.17120505
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.93541192
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.76580312
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.00721543
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.83174982
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29062967
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.19728970
12TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.03553365
13* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.6227904
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92998143
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86805327
16* FOXA2_19822575_ChIP-Seq_HepG2_Human1.62618043
17CLOCK_20551151_ChIP-Seq_293T_Human1.56820296
18GATA1_22025678_ChIP-Seq_K562_Human1.51206374
19HTT_18923047_ChIP-ChIP_STHdh_Human1.50772906
20* HNF4A_19822575_ChIP-Seq_HepG2_Human1.47186097
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31902630
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.30148691
23SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23873196
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23109637
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.17133256
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.16670956
27IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16189293
28IGF1R_20145208_ChIP-Seq_DFB_Human1.14844630
29RXRA_24833708_ChIP-Seq_LIVER_Mouse1.13259565
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11854078
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09207914
32EZH2_27294783_Chip-Seq_NPCs_Mouse1.08332389
33GATA4_25053715_ChIP-Seq_YYC3_Human1.08183376
34ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08038620
35TCF4_18268006_ChIP-ChIP_LS174T_Human1.05784495
36VDR_22108803_ChIP-Seq_LS180_Human1.05405693
37GBX2_23144817_ChIP-Seq_PC3_Human1.02266153
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01130333
39CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99588529
40SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99496503
41CDX2_20551321_ChIP-Seq_CACO-2_Human0.98293294
42ER_23166858_ChIP-Seq_MCF-7_Human0.97617241
43TP53_16413492_ChIP-PET_HCT116_Human0.96632528
44ZNF274_21170338_ChIP-Seq_K562_Hela0.95723966
45ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95570605
46SOX2_19829295_ChIP-Seq_ESCs_Human0.95118959
47NANOG_19829295_ChIP-Seq_ESCs_Human0.95118959
48KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95012425
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94161235
50PIAS1_25552417_ChIP-Seq_VCAP_Human0.94150635
51TCF4_22108803_ChIP-Seq_LS180_Human0.94063113
52IRF1_19129219_ChIP-ChIP_H3396_Human0.92466566
53TAF15_26573619_Chip-Seq_HEK293_Human0.89187894
54CRX_20693478_ChIP-Seq_RETINA_Mouse0.88329848
55ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87953407
56* MYC_19829295_ChIP-Seq_ESCs_Human0.87015054
57PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86524118
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85177669
59IRF8_22096565_ChIP-ChIP_GC-B_Human0.83997078
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83779262
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.83594647
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.83547687
63STAT3_23295773_ChIP-Seq_U87_Human0.83542498
64CBP_20019798_ChIP-Seq_JUKART_Human0.82627004
65IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82627004
66FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82231395
67FOXA1_25329375_ChIP-Seq_VCAP_Human0.82231395
68FOXH1_21741376_ChIP-Seq_EPCs_Human0.81034684
69HNFA_21074721_ChIP-Seq_CACO-2_Human0.80679126
70SMAD1_18555785_Chip-Seq_ESCs_Mouse0.79854866
71OCT4_18555785_Chip-Seq_ESCs_Mouse0.79568248
72RARG_19884340_ChIP-ChIP_MEFs_Mouse0.79441739
73AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79097389
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78718738
75* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77532239
76ESRRB_18555785_Chip-Seq_ESCs_Mouse0.77338671
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.77332887
78RUNX1_27457419_Chip-Seq_LIVER_Mouse0.76692409
79TP53_18474530_ChIP-ChIP_U2OS_Human0.76462533
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.76284133
81RARA_24833708_ChIP-Seq_LIVER_Mouse0.76132982
82ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75367587
83Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.74852672
84ESR2_21235772_ChIP-Seq_MCF-7_Human0.74557292
85PHF8_20622853_ChIP-Seq_HELA_Human0.74122390
86AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.73832552
87EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.73740799
88OCT4_21477851_ChIP-Seq_ESCs_Mouse0.73704061
89CBX2_22325352_ChIP-Seq_293T-Rex_Human0.73674631
90CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.73637739
91SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73600344
92SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73496281
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.73245930
94NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.72323235
95ETV1_20927104_ChIP-Seq_GIST48_Human0.71657048
96CTBP1_25329375_ChIP-Seq_LNCAP_Human0.70904274
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.68624841
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.68093307
99* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67619350
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.67612430
101ZNF263_19887448_ChIP-Seq_K562_Human0.67299280
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64397531
103GATA6_25053715_ChIP-Seq_YYC3_Human0.64278078
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.62940223
105RARB_24833708_ChIP-Seq_LIVER_Mouse0.61638187
106NRF2_20460467_ChIP-Seq_MEFs_Mouse0.61425394
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.61425394
108BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.61117529
109CEBPB_22108803_ChIP-Seq_LS180_Human0.60074165
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.58207815
111LXR_22292898_ChIP-Seq_THP-1_Human0.57846410
112PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.57613522
113EGR1_19032775_ChIP-ChIP_M12_Human0.57353933
114FOXA1_25552417_ChIP-Seq_VCAP_Human0.57019011
115FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56393021
116STAT1_17558387_ChIP-Seq_HELA_Human0.54188018
117MYC_19915707_ChIP-ChIP_AK7_Human0.53896064
118SOX2_20726797_ChIP-Seq_SW620_Human0.53857114
119AR_20517297_ChIP-Seq_VCAP_Human0.52941098
120FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.51925406
121FOXO3_23340844_ChIP-Seq_DLD1_Human0.51685447
122STAT3_1855785_ChIP-Seq_MESCs_Mouse0.50679774
123GATA2_19941826_ChIP-Seq_K562_Human0.50409768
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.50313789
125ESET_19884257_ChIP-Seq_ESCs_Mouse0.49966106
126PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.49123228
127ESR1_21235772_ChIP-Seq_MCF-7_Human0.49058962
128CBP_21632823_ChIP-Seq_H3396_Human0.49003540
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.47398482
130P53_21459846_ChIP-Seq_SAOS-2_Human0.47394860
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.46217203
132GATA1_19941826_ChIP-Seq_K562_Human0.45808539
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.45671919
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.43738118
135ESR1_20079471_ChIP-ChIP_T-47D_Human0.43728462
136PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.43721646
137TAF2_19829295_ChIP-Seq_ESCs_Human0.43385893
138CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.43338005
139SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42912314
140BCAT_22108803_ChIP-Seq_LS180_Human0.42332373
141MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.41810235
142CDX2_22108803_ChIP-Seq_LS180_Human0.38562972
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.38432764
144SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.38344832
145LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.37231468
146GATA3_24758297_ChIP-Seq_MCF-7_Human0.37225566
147ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.36183325
148CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.35879676
149SPI1_26923725_Chip-Seq_HPCs_Mouse0.35787531
150NCOR_22424771_ChIP-Seq_293T_Human0.35751857
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35715928
152ERG_21242973_ChIP-ChIP_JURKAT_Human0.35694566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.40033581
2MP0005360_urolithiasis8.23528465
3* MP0005085_abnormal_gallbladder_physiolo6.18286279
4MP0005365_abnormal_bile_salt5.97788754
5MP0008875_abnormal_xenobiotic_pharmacok5.29840713
6MP0003806_abnormal_nucleotide_metabolis4.07635033
7MP0010329_abnormal_lipoprotein_level3.67087402
8* MP0003252_abnormal_bile_duct3.65218453
9MP0009840_abnormal_foam_cell3.57941312
10* MP0001666_abnormal_nutrient_absorption2.98228954
11MP0005083_abnormal_biliary_tract2.81463887
12MP0005332_abnormal_amino_acid2.69395215
13MP0003195_calcinosis2.58825199
14MP0003191_abnormal_cellular_cholesterol2.24965568
15MP0004019_abnormal_vitamin_homeostasis2.23593678
16* MP0000609_abnormal_liver_physiology2.10787460
17* MP0002118_abnormal_lipid_homeostasis2.06554662
18MP0003868_abnormal_feces_composition1.80882153
19MP0002138_abnormal_hepatobiliary_system1.78387089
20MP0005319_abnormal_enzyme/_coenzyme1.78061975
21MP0009697_abnormal_copulation1.75326150
22MP0001764_abnormal_homeostasis1.62987979
23MP0005584_abnormal_enzyme/coenzyme_acti1.50759600
24MP0005451_abnormal_body_composition1.49314549
25MP0003122_maternal_imprinting1.26296408
26MP0009643_abnormal_urine_homeostasis1.25249010
27MP0003705_abnormal_hypodermis_morpholog1.21684723
28MP0003011_delayed_dark_adaptation1.19497678
29MP0002254_reproductive_system_inflammat1.16008397
30* MP0000598_abnormal_liver_morphology1.10635259
31MP0003186_abnormal_redox_activity1.09515876
32MP0000604_amyloidosis1.04017666
33MP0009764_decreased_sensitivity_to1.02002481
34MP0002132_abnormal_respiratory_system1.01473589
35MP0005647_abnormal_sex_gland1.00174901
36MP0003879_abnormal_hair_cell0.98717905
37MP0009763_increased_sensitivity_to0.95561951
38MP0005084_abnormal_gallbladder_morpholo0.94794464
39MP0005636_abnormal_mineral_homeostasis0.90087228
40* MP0009642_abnormal_blood_homeostasis0.86474303
41MP0008469_abnormal_protein_level0.85158901
42MP0002876_abnormal_thyroid_physiology0.84439411
43MP0010368_abnormal_lymphatic_system0.82070087
44MP0009765_abnormal_xenobiotic_induced0.80314129
45MP0005408_hypopigmentation0.80221459
46MP0000566_synostosis0.78972612
47MP0003183_abnormal_peptide_metabolism0.78325258
48MP0002078_abnormal_glucose_homeostasis0.76405316
49* MP0005376_homeostasis/metabolism_phenot0.74100288
50MP0006036_abnormal_mitochondrial_physio0.73780768
51MP0002971_abnormal_brown_adipose0.73621723
52MP0001915_intracranial_hemorrhage0.72435361
53MP0002822_catalepsy0.71223362
54MP0009053_abnormal_anal_canal0.70107846
55MP0005448_abnormal_energy_balance0.70056374
56MP0002282_abnormal_trachea_morphology0.69932066
57* MP0003656_abnormal_erythrocyte_physiolo0.69759673
58MP0005670_abnormal_white_adipose0.68773947
59MP0005334_abnormal_fat_pad0.68715776
60MP0005220_abnormal_exocrine_pancreas0.62226435
61MP0005535_abnormal_body_temperature0.62032361
62MP0002168_other_aberrant_phenotype0.61123977
63MP0002089_abnormal_postnatal_growth/wei0.59646160
64MP0005551_abnormal_eye_electrophysiolog0.59054052
65MP0003690_abnormal_glial_cell0.58352326
66MP0004130_abnormal_muscle_cell0.57616133
67MP0003329_amyloid_beta_deposits0.57222001
68MP0001756_abnormal_urination0.56636507
69* MP0005266_abnormal_metabolism0.56541038
70MP0003123_paternal_imprinting0.55524372
71MP0006292_abnormal_olfactory_placode0.55428460
72MP0001986_abnormal_taste_sensitivity0.54878043
73MP0005187_abnormal_penis_morphology0.54490230
74MP0004264_abnormal_extraembryonic_tissu0.54230293
75MP0001661_extended_life_span0.53397476
76MP0000639_abnormal_adrenal_gland0.53067068
77MP0006035_abnormal_mitochondrial_morpho0.52528636
78MP0003718_maternal_effect0.52480943
79MP0002909_abnormal_adrenal_gland0.51143165
80MP0010234_abnormal_vibrissa_follicle0.50666749
81MP0003638_abnormal_response/metabolism_0.50215418
82MP0002136_abnormal_kidney_physiology0.48770547
83MP0002249_abnormal_larynx_morphology0.47864262
84MP0005646_abnormal_pituitary_gland0.47205065
85MP0008872_abnormal_physiological_respon0.46680589
86MP0008873_increased_physiological_sensi0.45921325
87MP0005395_other_phenotype0.45280617
88MP0008874_decreased_physiological_sensi0.43584863
89MP0005379_endocrine/exocrine_gland_phen0.43042306
90MP0005409_darkened_coat_color0.42769106
91MP0002938_white_spotting0.42746702
92MP0002796_impaired_skin_barrier0.41780512
93MP0004782_abnormal_surfactant_physiolog0.41626939
94MP0003953_abnormal_hormone_level0.41546882
95MP0005410_abnormal_fertilization0.40760083
96MP0005248_abnormal_Harderian_gland0.40745525
97MP0005166_decreased_susceptibility_to0.39895702
98MP0003436_decreased_susceptibility_to0.39768858
99MP0004142_abnormal_muscle_tone0.37724115
100MP0009780_abnormal_chondrocyte_physiolo0.37259047
101MP0009115_abnormal_fat_cell0.37009538
102MP0003172_abnormal_lysosome_physiology0.36890757
103* MP0005464_abnormal_platelet_physiology0.36516531
104MP0002928_abnormal_bile_duct0.36404965
105MP0005666_abnormal_adipose_tissue0.36358651
106MP0005058_abnormal_lysosome_morphology0.35382743
107MP0003075_altered_response_to0.35203812
108MP0003724_increased_susceptibility_to0.35129343
109MP0000579_abnormal_nail_morphology0.34911406
110MP0005164_abnormal_response_to0.33584328
111MP0009384_cardiac_valve_regurgitation0.33455054
112MP0000230_abnormal_systemic_arterial0.33319760
113MP0000249_abnormal_blood_vessel0.32794308
114MP0005377_hearing/vestibular/ear_phenot0.32427746
115MP0003878_abnormal_ear_physiology0.32427746
116MP0001324_abnormal_eye_pigmentation0.31996849
117MP0003633_abnormal_nervous_system0.31653670
118MP0004147_increased_porphyrin_level0.31479035
119MP0001944_abnormal_pancreas_morphology0.31471548
120MP0001881_abnormal_mammary_gland0.31443775
121MP0004043_abnormal_pH_regulation0.30500140
122MP0001243_abnormal_dermal_layer0.30199098
123MP0006082_CNS_inflammation0.30051244
124MP0000538_abnormal_urinary_bladder0.29817989
125MP0009672_abnormal_birth_weight0.29356693
126MP0004883_abnormal_blood_vessel0.28730108
127MP0002160_abnormal_reproductive_system0.28336093
128MP0002837_dystrophic_cardiac_calcinosis0.28288817
129MP0001845_abnormal_inflammatory_respons0.28185191
130MP0002970_abnormal_white_adipose0.27145516
131MP0005167_abnormal_blood-brain_barrier0.26926503
132MP0003300_gastrointestinal_ulcer0.26414316
133MP0001853_heart_inflammation0.26032293
134MP0002135_abnormal_kidney_morphology0.23993305
135MP0003943_abnormal_hepatobiliary_system0.22927025

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.22127500
2Intrahepatic cholestasis (HP:0001406)7.21437472
3Deep venous thrombosis (HP:0002625)7.13422453
4Hypobetalipoproteinemia (HP:0003563)7.01870195
5Abnormality of monocarboxylic acid metabolism (HP:0010996)6.70427923
6Xanthomatosis (HP:0000991)6.34503929
7Prolonged partial thromboplastin time (HP:0003645)6.32673194
8Hyperlipoproteinemia (HP:0010980)5.39688982
9Hypolipoproteinemia (HP:0010981)5.07447830
10Complement deficiency (HP:0004431)4.96774444
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.71137205
12Epidermoid cyst (HP:0200040)4.60742650
13Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.58328263
14Hyperammonemia (HP:0001987)4.58307298
15Joint hemorrhage (HP:0005261)4.50100937
16Fat malabsorption (HP:0002630)4.35065861
17Abnormality of sulfur amino acid metabolism (HP:0004339)4.29826509
18Abnormality of the common coagulation pathway (HP:0010990)4.28821514
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22372941
20Hyperglycinemia (HP:0002154)4.18637905
21Conjugated hyperbilirubinemia (HP:0002908)4.18390578
22Hypoalphalipoproteinemia (HP:0003233)4.16921302
23Ketosis (HP:0001946)4.16743993
24Hyperglycinuria (HP:0003108)4.11279785
25Abnormality of methionine metabolism (HP:0010901)4.08288062
26Abnormality of glycine metabolism (HP:0010895)3.98454102
27Abnormality of serine family amino acid metabolism (HP:0010894)3.98454102
28Hypoglycemic coma (HP:0001325)3.82394170
29Abnormality of pyrimidine metabolism (HP:0004353)3.80970605
30Abnormality of the intrinsic pathway (HP:0010989)3.63523134
31Abnormality of complement system (HP:0005339)3.62448930
32Hyperbilirubinemia (HP:0002904)3.41224793
33Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.37678696
34* Hypercholesterolemia (HP:0003124)3.37433264
35Abnormality of fatty-acid metabolism (HP:0004359)3.29331359
36Acanthocytosis (HP:0001927)3.20495684
37Abnormality of nucleobase metabolism (HP:0010932)3.13324861
38Steatorrhea (HP:0002570)3.03134561
39Delayed CNS myelination (HP:0002188)3.00861112
40Ketoacidosis (HP:0001993)3.00472079
41Myocardial infarction (HP:0001658)2.89159418
42Abnormality of serum amino acid levels (HP:0003112)2.88434880
43Hepatocellular carcinoma (HP:0001402)2.87316432
44Spontaneous abortion (HP:0005268)2.85871561
45Metabolic acidosis (HP:0001942)2.85849749
46Skin nodule (HP:0200036)2.81724936
47Abnormality of purine metabolism (HP:0004352)2.79501989
48Malnutrition (HP:0004395)2.78381228
49Hypochromic microcytic anemia (HP:0004840)2.77090426
50Osteomalacia (HP:0002749)2.72194212
51Systemic lupus erythematosus (HP:0002725)2.64717153
52Vascular calcification (HP:0004934)2.63223299
53Fair hair (HP:0002286)2.61652896
54Lethargy (HP:0001254)2.54634723
55Abnormal gallbladder morphology (HP:0012437)2.53698530
56Dicarboxylic aciduria (HP:0003215)2.51806809
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51806809
58Cholelithiasis (HP:0001081)2.48041451
59Hypoglycemic seizures (HP:0002173)2.46808378
60Abnormal gallbladder physiology (HP:0012438)2.40855884
61Cholecystitis (HP:0001082)2.40855884
62Spastic diplegia (HP:0001264)2.38585195
63Hydroxyprolinuria (HP:0003080)2.38298049
64Abnormality of proline metabolism (HP:0010907)2.38298049
65Glomerulonephritis (HP:0000099)2.37808309
66Irritability (HP:0000737)2.34104548
67Cardiovascular calcification (HP:0011915)2.32999880
68Gout (HP:0001997)2.30312654
69Purpura (HP:0000979)2.28848616
70Amyloidosis (HP:0011034)2.28575810
71Mitral stenosis (HP:0001718)2.28478096
72Cerebral edema (HP:0002181)2.28286783
73Arthropathy (HP:0003040)2.24123679
74Hyperphosphaturia (HP:0003109)2.20027969
75Late onset (HP:0003584)2.19863084
76Pancreatitis (HP:0001733)2.19184384
77Esophageal varix (HP:0002040)2.18350226
78Neonatal onset (HP:0003623)2.17346624
79Sensorimotor neuropathy (HP:0007141)2.17294466
80Gingival bleeding (HP:0000225)2.07154676
81Brushfield spots (HP:0001088)2.06808520
82Menorrhagia (HP:0000132)2.06159846
83Reduced antithrombin III activity (HP:0001976)2.05735850
84Vomiting (HP:0002013)2.04990532
85Recurrent gram-negative bacterial infections (HP:0005420)2.04399673
86Abnormality of the gallbladder (HP:0005264)2.04208304
87Pulmonary embolism (HP:0002204)2.03663003
88Hyperinsulinemic hypoglycemia (HP:0000825)2.01437086
89Generalized aminoaciduria (HP:0002909)2.00603297
90Hemorrhage of the eye (HP:0011885)2.00173519
91Enlarged kidneys (HP:0000105)1.99246514
92Opisthotonus (HP:0002179)1.97572463
93Rickets (HP:0002748)1.97381334
94Thrombophlebitis (HP:0004418)1.95175391
95* Poikilocytosis (HP:0004447)1.94967448
96Abnormality of transition element cation homeostasis (HP:0011030)1.92622197
97Proximal tubulopathy (HP:0000114)1.91977905
98Abnormality of vitamin metabolism (HP:0100508)1.91889411
99Abnormal cartilage morphology (HP:0002763)1.90114827
100Glycosuria (HP:0003076)1.89199047
101Abnormality of urine glucose concentration (HP:0011016)1.89199047
102Abnormality of iron homeostasis (HP:0011031)1.89152071
103Hypophosphatemic rickets (HP:0004912)1.86983674
104Abnormal urine phosphate concentration (HP:0012599)1.86473546
105Renal cortical cysts (HP:0000803)1.79469245
106Elevated hepatic transaminases (HP:0002910)1.79458830
107Abnormal enzyme/coenzyme activity (HP:0012379)1.79048447
108Bifid scrotum (HP:0000048)1.78843019
109Facial shape deformation (HP:0011334)1.78429729
110Potter facies (HP:0002009)1.78429729
111Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77472699
112Abnormality of alanine metabolism (HP:0010916)1.77472699
113Hyperalaninemia (HP:0003348)1.77472699
114Nephritis (HP:0000123)1.76992652
115Hyperglycemia (HP:0003074)1.76064654
116Abnormal tarsal ossification (HP:0008369)1.72180448
117Generalized hypopigmentation of hair (HP:0011358)1.71842704
118Joint swelling (HP:0001386)1.70249155
119Retinal atrophy (HP:0001105)1.67925095
120Increased serum pyruvate (HP:0003542)1.67336579
121Pigmentary retinal degeneration (HP:0001146)1.63176079
122Abnormal biliary tract physiology (HP:0012439)1.62869154
123Bile duct proliferation (HP:0001408)1.62869154
124Megaloblastic anemia (HP:0001889)1.58844579
125Hypothermia (HP:0002045)1.58047483
126Gangrene (HP:0100758)1.52000347
127Alkalosis (HP:0001948)1.51832465

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.60859087
2SIK14.42283468
3FGFR44.34532121
4ERN14.33175692
5WNK43.29112808
6TAOK33.09363584
7ACVR1B2.94176077
8INSRR2.88440840
9MST1R2.86575015
10ERBB42.72677793
11FRK2.72224720
12PKN22.20453242
13MAP2K42.16501095
14STK392.02761040
15NTRK32.00321581
16PTK61.83746336
17MAPK111.83726196
18TNIK1.82280493
19TRIM281.79268305
20FLT31.77612630
21PDK21.73375400
22LATS11.73052119
23TYK21.70585459
24GRK61.67432781
25PIK3CG1.64562895
26TRIB31.54564303
27NLK1.47653359
28MAP3K101.45040171
29BCR1.37316000
30WNK31.34576131
31ABL21.34198851
32DAPK21.32965156
33MAP3K71.30846506
34EIF2AK11.24094199
35BMPR1B1.23614684
36OXSR11.23326589
37PRKAA21.22558990
38BRSK21.21769179
39FGFR21.21320640
40NEK91.19798159
41JAK21.18910656
42CASK1.18161421
43KDR1.17763433
44CAMKK21.17298187
45TBK11.13573569
46ERBB21.13165869
47FGFR11.08995326
48MET1.08921054
49RIPK11.05018980
50ADRBK21.03806168
51SGK4940.98464014
52SGK2230.98464014
53FER0.97551043
54MAPK40.95715279
55EPHB10.94450438
56MAP3K140.94324220
57JAK10.93755991
58MAP2K30.93621253
59MAP2K60.92201390
60MAP3K110.91377602
61IRAK10.91186568
62PRKCZ0.90270272
63MAP3K30.89540809
64PINK10.87282196
65AKT30.85736846
66MAP3K120.83582571
67MAP4K20.81447295
68CDK60.81258110
69MAPK150.80728608
70PRKG10.76242700
71PRKACA0.75677411
72PRKACG0.74922069
73CSK0.74494914
74DYRK1B0.73962611
75STK38L0.73721678
76EPHA30.70518190
77CSNK1E0.70483346
78SGK10.69631653
79IRAK30.69288748
80PRKAA10.68719328
81PTK20.68198650
82CSNK1D0.67820938
83CAMK2G0.66742350
84MAPK120.65280178
85GSK3A0.63777280
86MAP2K20.62355104
87EIF2AK30.61068553
88CAMK1D0.60439465
89SGK30.58784027
90PRKG20.58493363
91PRKCE0.58330387
92MAPKAPK30.56482796
93PDPK10.56470674
94MAP3K20.55229946
95TIE10.55222739
96IKBKE0.54400077
97FGFR30.54182147
98DYRK20.54035923
99RPS6KB10.52748162
100GRK10.52490546
101PRKCQ0.52391722
102TRPM70.50975654
103NUAK10.49676612
104MAP3K40.49442890
105ZAK0.49311827
106MAP2K10.48256681
107ICK0.47793004
108MAPK70.47010083
109STK240.46336327
110TAOK20.45621198
111PBK0.45381222
112CSF1R0.43812375
113CSNK2A10.43692165
114PRKACB0.43595875
115TGFBR20.43425440
116RPS6KA30.42612190
117EPHA20.42524651
118PRKCB0.42116095
119MAP3K10.41694252
120EPHA40.41644959
121MATK0.41549850
122IGF1R0.41170017
123CSNK1G10.41066056
124CSNK2A20.41014862
125MAP3K50.40595447
126RET0.39698176
127NEK60.39490661
128TYRO30.38703410
129CSNK1A10.37757569
130CDK40.37355117
131MAP3K130.36330934
132MAPK130.35540234
133PDK10.35391786
134EPHB20.35108769
135MINK10.34660218
136BMX0.34507275
137PIK3CA0.33223290
138SRC0.31313400
139SGK20.31126148
140PRKCA0.30258523
141MTOR0.29207572
142EGFR0.29091792
143LMTK20.28530192
144MAP3K60.26782706
145CAMK40.25555358
146PRKCG0.23435250
147PAK30.22041406
148CSNK1G20.20175081
149ABL10.19094027
150PDK30.18496143

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.28577870
2Nitrogen metabolism_Homo sapiens_hsa009103.50374271
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43528139
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.21091765
5Arginine biosynthesis_Homo sapiens_hsa002203.04093597
6Tryptophan metabolism_Homo sapiens_hsa003802.70348046
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.63680817
8Complement and coagulation cascades_Homo sapiens_hsa046102.56372013
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51183285
10Fatty acid degradation_Homo sapiens_hsa000712.47483113
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.39584206
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30432929
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29018023
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.19157092
15Caffeine metabolism_Homo sapiens_hsa002322.07844767
16Butanoate metabolism_Homo sapiens_hsa006502.07178103
17Peroxisome_Homo sapiens_hsa041462.01478974
18Histidine metabolism_Homo sapiens_hsa003402.00006413
19Chemical carcinogenesis_Homo sapiens_hsa052041.95729958
20Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.95099311
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.92129034
22PPAR signaling pathway_Homo sapiens_hsa033201.91459634
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.82659210
24Propanoate metabolism_Homo sapiens_hsa006401.82076456
25Fatty acid metabolism_Homo sapiens_hsa012121.75876690
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.73963502
27Retinol metabolism_Homo sapiens_hsa008301.72553900
28beta-Alanine metabolism_Homo sapiens_hsa004101.69572609
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64881701
30Staphylococcus aureus infection_Homo sapiens_hsa051501.62427391
31* Fat digestion and absorption_Homo sapiens_hsa049751.57950172
32* Bile secretion_Homo sapiens_hsa049761.56490024
33Selenocompound metabolism_Homo sapiens_hsa004501.52920066
34Starch and sucrose metabolism_Homo sapiens_hsa005001.52347581
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51623891
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50441504
37Phenylalanine metabolism_Homo sapiens_hsa003601.49794793
38Sulfur metabolism_Homo sapiens_hsa009201.43468165
39Folate biosynthesis_Homo sapiens_hsa007901.39907425
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37837076
41Tyrosine metabolism_Homo sapiens_hsa003501.36170821
42Pyruvate metabolism_Homo sapiens_hsa006201.35975907
43Fatty acid elongation_Homo sapiens_hsa000621.25611037
44Vitamin digestion and absorption_Homo sapiens_hsa049771.22354001
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.22311536
46Biosynthesis of amino acids_Homo sapiens_hsa012301.16755551
47Steroid biosynthesis_Homo sapiens_hsa001001.15148056
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.14478784
49* ABC transporters_Homo sapiens_hsa020101.11762057
50Carbon metabolism_Homo sapiens_hsa012001.11660684
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.06569844
52Arginine and proline metabolism_Homo sapiens_hsa003301.01709756
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99955968
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99023257
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96924145
56Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93132749
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.90004735
58Sulfur relay system_Homo sapiens_hsa041220.84783330
59Lysine degradation_Homo sapiens_hsa003100.80825052
60Vitamin B6 metabolism_Homo sapiens_hsa007500.78362203
61Glycerolipid metabolism_Homo sapiens_hsa005610.78101398
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74224402
63Glutathione metabolism_Homo sapiens_hsa004800.73000397
64One carbon pool by folate_Homo sapiens_hsa006700.63678104
65Pentose phosphate pathway_Homo sapiens_hsa000300.58234185
66Galactose metabolism_Homo sapiens_hsa000520.53069293
67Fatty acid biosynthesis_Homo sapiens_hsa000610.52935364
68Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52328851
69Metabolic pathways_Homo sapiens_hsa011000.46199475
70Fructose and mannose metabolism_Homo sapiens_hsa000510.38947782
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31245362
72Linoleic acid metabolism_Homo sapiens_hsa005910.27799936
73Renin-angiotensin system_Homo sapiens_hsa046140.26261404
74Prion diseases_Homo sapiens_hsa050200.24317078
75Insulin resistance_Homo sapiens_hsa049310.23369250
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.22045886
77Adipocytokine signaling pathway_Homo sapiens_hsa049200.19656938
78Pertussis_Homo sapiens_hsa051330.19011960
79Other glycan degradation_Homo sapiens_hsa005110.13814474
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.12583827
81Mineral absorption_Homo sapiens_hsa049780.11489290
82Sphingolipid metabolism_Homo sapiens_hsa006000.09968863
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09833055
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.07327470
85Glucagon signaling pathway_Homo sapiens_hsa049220.06749857
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.02254281
87AMPK signaling pathway_Homo sapiens_hsa041520.00785971
88N-Glycan biosynthesis_Homo sapiens_hsa005100.00706966
89Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2283525
90Bladder cancer_Homo sapiens_hsa05219-0.2214572
91Systemic lupus erythematosus_Homo sapiens_hsa05322-0.2194499
92Ether lipid metabolism_Homo sapiens_hsa00565-0.2182067
93Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.2144002
94Type II diabetes mellitus_Homo sapiens_hsa04930-0.2091795
95Regulation of autophagy_Homo sapiens_hsa04140-0.1983177
96Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1592450
97Protein export_Homo sapiens_hsa03060-0.1589391
98Hepatitis C_Homo sapiens_hsa05160-0.1545631
99Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1421482
100Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1294923
101Circadian rhythm_Homo sapiens_hsa04710-0.1210838
102African trypanosomiasis_Homo sapiens_hsa05143-0.1173197
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1149454
104Insulin signaling pathway_Homo sapiens_hsa04910-0.1138209
105Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1114364
106Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0826583
107Protein digestion and absorption_Homo sapiens_hsa04974-0.0613320
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0550188
109Serotonergic synapse_Homo sapiens_hsa04726-0.0234158

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