ABHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the AB hydrolase superfamily and encodes a protein with an alpha/beta hydrolase fold. This domain is common to a number of hydrolytic enzymes of widely differing phylogenetic origins and catalytic functions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.64877920
2response to pheromone (GO:0019236)5.37739755
3L-fucose catabolic process (GO:0042355)4.37304908
4fucose catabolic process (GO:0019317)4.37304908
5L-fucose metabolic process (GO:0042354)4.37304908
6sperm motility (GO:0030317)4.20047972
7protein polyglutamylation (GO:0018095)4.16225869
8DNA deamination (GO:0045006)4.11070319
9multicellular organism reproduction (GO:0032504)3.98800185
10cellular ketone body metabolic process (GO:0046950)3.97005458
11regulation of cilium movement (GO:0003352)3.80800340
12water-soluble vitamin biosynthetic process (GO:0042364)3.69680454
13epithelial cilium movement (GO:0003351)3.60327768
14ketone body metabolic process (GO:1902224)3.58538087
15detection of light stimulus involved in sensory perception (GO:0050962)3.55203688
16detection of light stimulus involved in visual perception (GO:0050908)3.55203688
17negative regulation of mast cell activation (GO:0033004)3.52364470
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.49478986
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.48375217
20piRNA metabolic process (GO:0034587)3.46031278
21indolalkylamine metabolic process (GO:0006586)3.43263315
22acrosome reaction (GO:0007340)3.39489630
23mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35472693
24mitochondrial respiratory chain complex I assembly (GO:0032981)3.35472693
25NADH dehydrogenase complex assembly (GO:0010257)3.35472693
26protein complex biogenesis (GO:0070271)3.28812373
27nonmotile primary cilium assembly (GO:0035058)3.16937307
28preassembly of GPI anchor in ER membrane (GO:0016254)3.13258565
29tryptophan catabolic process (GO:0006569)3.08716382
30indole-containing compound catabolic process (GO:0042436)3.08716382
31indolalkylamine catabolic process (GO:0046218)3.08716382
32mitochondrial respiratory chain complex assembly (GO:0033108)3.08363965
33kynurenine metabolic process (GO:0070189)3.07558974
34axoneme assembly (GO:0035082)3.04430340
35sulfation (GO:0051923)2.98588531
36nephron tubule morphogenesis (GO:0072078)2.98307797
37nephron epithelium morphogenesis (GO:0072088)2.98307797
38negative regulation of telomere maintenance (GO:0032205)2.97599918
39primary amino compound metabolic process (GO:1901160)2.96087488
40platelet dense granule organization (GO:0060155)2.93107949
41DNA methylation involved in gamete generation (GO:0043046)2.88899170
42establishment of protein localization to Golgi (GO:0072600)2.86909556
43cilium movement (GO:0003341)2.86619962
44male meiosis I (GO:0007141)2.84510150
45neuronal action potential (GO:0019228)2.84297049
46regulation of action potential (GO:0098900)2.83261114
47regulation of microtubule-based movement (GO:0060632)2.79911153
48cornea development in camera-type eye (GO:0061303)2.77949202
49gamma-aminobutyric acid transport (GO:0015812)2.76612858
50respiratory chain complex IV assembly (GO:0008535)2.75702490
51regulation of hexokinase activity (GO:1903299)2.74712378
52regulation of glucokinase activity (GO:0033131)2.74712378
53ubiquinone biosynthetic process (GO:0006744)2.71503363
54indole-containing compound metabolic process (GO:0042430)2.71355959
55tryptophan metabolic process (GO:0006568)2.70815471
56cAMP catabolic process (GO:0006198)2.69998128
57fusion of sperm to egg plasma membrane (GO:0007342)2.69007306
58cilium organization (GO:0044782)2.66081829
59synaptic transmission, cholinergic (GO:0007271)2.65448064
60positive regulation of fatty acid transport (GO:2000193)2.65411990
61reproduction (GO:0000003)2.64973657
62spermatid development (GO:0007286)2.64177699
63dopamine transport (GO:0015872)2.62954728
64regulation of rhodopsin mediated signaling pathway (GO:0022400)2.61837994
65protein-cofactor linkage (GO:0018065)2.61110128
66photoreceptor cell maintenance (GO:0045494)2.60171155
67protein targeting to Golgi (GO:0000042)2.59713763
68reciprocal DNA recombination (GO:0035825)2.59693192
69reciprocal meiotic recombination (GO:0007131)2.59693192
70rhodopsin mediated signaling pathway (GO:0016056)2.59052284
71spinal cord motor neuron differentiation (GO:0021522)2.58410584
72mannosylation (GO:0097502)2.58193872
73cilium assembly (GO:0042384)2.57921331
74serotonin metabolic process (GO:0042428)2.57438855
75reflex (GO:0060004)2.56534513
76cilium morphogenesis (GO:0060271)2.55065623
77amine catabolic process (GO:0009310)2.54708325
78cellular biogenic amine catabolic process (GO:0042402)2.54708325
79axonemal dynein complex assembly (GO:0070286)2.54032660
80cytochrome complex assembly (GO:0017004)2.52796189
81behavioral response to ethanol (GO:0048149)2.52281995
82protein K6-linked ubiquitination (GO:0085020)2.50159734
83sperm-egg recognition (GO:0035036)2.48485919
84negative regulation of cytosolic calcium ion concentration (GO:0051481)2.48362111
85male meiosis (GO:0007140)2.47935970
86cilium or flagellum-dependent cell motility (GO:0001539)2.47612252
87regulation of nuclear cell cycle DNA replication (GO:0033262)2.47453511
88negative regulation of reactive oxygen species metabolic process (GO:2000378)2.46440945
89protein localization to Golgi apparatus (GO:0034067)2.45160724
90regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.44185968
91rRNA methylation (GO:0031167)2.43905615
92ubiquinone metabolic process (GO:0006743)2.42642252
93organic cation transport (GO:0015695)2.41601249
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.41379319
95membrane depolarization during action potential (GO:0086010)2.40414063
96positive regulation of prostaglandin secretion (GO:0032308)2.40239769
97S-adenosylmethionine metabolic process (GO:0046500)2.39063877
98replication fork processing (GO:0031297)2.38243257
99calcium ion-dependent exocytosis (GO:0017156)2.38035030
100NAD biosynthetic process (GO:0009435)2.37798884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.02322730
2EZH2_22144423_ChIP-Seq_EOC_Human3.42714360
3VDR_22108803_ChIP-Seq_LS180_Human3.21870728
4GBX2_23144817_ChIP-Seq_PC3_Human2.56355544
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30093400
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.27869645
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.12935668
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11865791
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.11046368
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.08668236
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07768522
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05122955
13FUS_26573619_Chip-Seq_HEK293_Human2.03419726
14IGF1R_20145208_ChIP-Seq_DFB_Human2.00200264
15* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.95209368
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94195685
17ER_23166858_ChIP-Seq_MCF-7_Human1.93260690
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.88726445
19P300_19829295_ChIP-Seq_ESCs_Human1.87553663
20EWS_26573619_Chip-Seq_HEK293_Human1.80604887
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76221093
22TAF15_26573619_Chip-Seq_HEK293_Human1.75347880
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.71495835
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.65671825
25CBP_20019798_ChIP-Seq_JUKART_Human1.65671825
26IRF1_19129219_ChIP-ChIP_H3396_Human1.59995726
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56219363
28* TP53_22573176_ChIP-Seq_HFKS_Human1.56205494
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56205443
30GATA3_21878914_ChIP-Seq_MCF-7_Human1.51889019
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50792715
32FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46160822
33FOXA1_25329375_ChIP-Seq_VCAP_Human1.46160822
34MYC_18940864_ChIP-ChIP_HL60_Human1.43759314
35REST_21632747_ChIP-Seq_MESCs_Mouse1.42399667
36MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41477197
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40432782
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.39312816
39AR_25329375_ChIP-Seq_VCAP_Human1.38773568
40NANOG_19829295_ChIP-Seq_ESCs_Human1.37756997
41SOX2_19829295_ChIP-Seq_ESCs_Human1.37756997
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.37638145
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.36981515
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36981515
45AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35864362
46ETV2_25802403_ChIP-Seq_MESCs_Mouse1.35697487
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34382824
48BCAT_22108803_ChIP-Seq_LS180_Human1.34282430
49STAT3_23295773_ChIP-Seq_U87_Human1.33216023
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31847457
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30356259
52GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28994572
53SMAD4_21799915_ChIP-Seq_A2780_Human1.28456577
54EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25691911
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.25171184
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24942559
57TCF4_23295773_ChIP-Seq_U87_Human1.24483578
58HOXB7_26014856_ChIP-Seq_BT474_Human1.23966421
59ERA_21632823_ChIP-Seq_H3396_Human1.23892520
60MYC_19829295_ChIP-Seq_ESCs_Human1.22591263
61AR_20517297_ChIP-Seq_VCAP_Human1.21885915
62NCOR_22424771_ChIP-Seq_293T_Human1.21870530
63TAF2_19829295_ChIP-Seq_ESCs_Human1.21482165
64NANOG_20526341_ChIP-Seq_ESCs_Human1.20270038
65FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19544752
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18713392
67SMAD4_21741376_ChIP-Seq_EPCs_Human1.18576672
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.18260440
69AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17143613
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.16719565
71SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16395403
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15881383
73RNF2_27304074_Chip-Seq_NSC_Mouse1.15592482
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15375491
75EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13901829
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.12978371
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12885687
78TCF4_22108803_ChIP-Seq_LS180_Human1.12676807
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12563456
80RUNX2_22187159_ChIP-Seq_PCA_Human1.12441775
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12404910
82EST1_17652178_ChIP-ChIP_JURKAT_Human1.12269354
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12137825
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11805248
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.10432857
86P53_21459846_ChIP-Seq_SAOS-2_Human1.08916175
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.06150974
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04392357
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.02069452
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01209328
91FOXH1_21741376_ChIP-Seq_EPCs_Human1.01133851
92TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00710990
93REST_18959480_ChIP-ChIP_MESCs_Mouse1.00389992
94FLI1_21867929_ChIP-Seq_TH2_Mouse1.00013103
95OCT4_20526341_ChIP-Seq_ESCs_Human0.99938116
96DROSHA_22980978_ChIP-Seq_HELA_Human0.98112861
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97972071
98EZH2_27294783_Chip-Seq_ESCs_Mouse0.95367108
99VDR_23849224_ChIP-Seq_CD4+_Human0.94909962
100RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94423796

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization2.86207357
2MP0008877_abnormal_DNA_methylation2.79653104
3MP0003195_calcinosis2.73912135
4MP0003011_delayed_dark_adaptation2.52783838
5MP0005551_abnormal_eye_electrophysiolog2.50167031
6MP0001968_abnormal_touch/_nociception2.42266260
7MP0003646_muscle_fatigue2.41651905
8MP0006072_abnormal_retinal_apoptosis2.27379048
9MP0001986_abnormal_taste_sensitivity2.19170418
10MP0002837_dystrophic_cardiac_calcinosis2.18950016
11MP0002102_abnormal_ear_morphology2.09415089
12MP0005253_abnormal_eye_physiology2.01638929
13MP0004142_abnormal_muscle_tone1.99460329
14MP0008875_abnormal_xenobiotic_pharmacok1.97783822
15MP0003136_yellow_coat_color1.93800773
16MP0001485_abnormal_pinna_reflex1.88591370
17MP0002736_abnormal_nociception_after1.87671751
18MP0002653_abnormal_ependyma_morphology1.85198317
19MP0009046_muscle_twitch1.84486550
20MP0002876_abnormal_thyroid_physiology1.81126684
21MP0006292_abnormal_olfactory_placode1.80270260
22MP0005377_hearing/vestibular/ear_phenot1.79944702
23MP0003878_abnormal_ear_physiology1.79944702
24MP0009745_abnormal_behavioral_response1.78743689
25MP0004885_abnormal_endolymph1.76599962
26MP0008872_abnormal_physiological_respon1.75371399
27MP0000569_abnormal_digit_pigmentation1.74986500
28MP0002638_abnormal_pupillary_reflex1.72879065
29MP0002272_abnormal_nervous_system1.72173990
30MP0005645_abnormal_hypothalamus_physiol1.71281620
31MP0005646_abnormal_pituitary_gland1.66291987
32MP0001984_abnormal_olfaction1.59831546
33MP0003880_abnormal_central_pattern1.56952387
34MP0000372_irregular_coat_pigmentation1.54954329
35MP0000427_abnormal_hair_cycle1.52013394
36MP0006276_abnormal_autonomic_nervous1.50236990
37MP0004145_abnormal_muscle_electrophysio1.49688384
38MP0001486_abnormal_startle_reflex1.48078365
39MP0005084_abnormal_gallbladder_morpholo1.45214253
40MP0002138_abnormal_hepatobiliary_system1.44812131
41MP0004043_abnormal_pH_regulation1.43825662
42MP0001501_abnormal_sleep_pattern1.40037601
43MP0003698_abnormal_male_reproductive1.39346797
44MP0004133_heterotaxia1.38776774
45MP0001529_abnormal_vocalization1.37703276
46MP0002733_abnormal_thermal_nociception1.35271340
47MP0005389_reproductive_system_phenotype1.34899116
48MP0002735_abnormal_chemical_nociception1.32855879
49MP0004742_abnormal_vestibular_system1.32346778
50MP0003718_maternal_effect1.31108779
51MP0001970_abnormal_pain_threshold1.29507865
52MP0002160_abnormal_reproductive_system1.29417440
53MP0002938_white_spotting1.27085088
54MP0001929_abnormal_gametogenesis1.25954854
55MP0002572_abnormal_emotion/affect_behav1.25733979
56MP0002557_abnormal_social/conspecific_i1.25082613
57MP0001919_abnormal_reproductive_system1.19432584
58MP0005174_abnormal_tail_pigmentation1.18951116
59MP0003787_abnormal_imprinting1.18775415
60MP0005379_endocrine/exocrine_gland_phen1.18657316
61MP0002928_abnormal_bile_duct1.18151723
62MP0002064_seizures1.16909894
63MP0005423_abnormal_somatic_nervous1.15753786
64MP0001905_abnormal_dopamine_level1.15043738
65MP0000631_abnormal_neuroendocrine_gland1.11496037
66MP0002067_abnormal_sensory_capabilities1.10891489
67MP0005386_behavior/neurological_phenoty1.07548355
68MP0004924_abnormal_behavior1.07548355
69MP0002234_abnormal_pharynx_morphology1.06660118
70MP0002163_abnormal_gland_morphology1.06082950
71MP0004147_increased_porphyrin_level1.04899678
72MP0002095_abnormal_skin_pigmentation1.03050481
73MP0003137_abnormal_impulse_conducting1.00675074
74MP0003252_abnormal_bile_duct0.99753255
75MP0000230_abnormal_systemic_arterial0.98912983
76MP0004215_abnormal_myocardial_fiber0.98147332
77MP0005195_abnormal_posterior_eye0.97449611
78MP0010386_abnormal_urinary_bladder0.94949838
79MP0000383_abnormal_hair_follicle0.94535619
80MP0002210_abnormal_sex_determination0.93341940
81MP0005332_abnormal_amino_acid0.93011099
82MP0005075_abnormal_melanosome_morpholog0.92412608
83MP0000026_abnormal_inner_ear0.92108761
84MP0001963_abnormal_hearing_physiology0.91656022
85MP0003635_abnormal_synaptic_transmissio0.89083361
86MP0005671_abnormal_response_to0.87937649
87MP0002063_abnormal_learning/memory/cond0.85600165
88MP0005167_abnormal_blood-brain_barrier0.85329740
89MP0005085_abnormal_gallbladder_physiolo0.84921841
90MP0002277_abnormal_respiratory_mucosa0.84218654
91MP0002229_neurodegeneration0.83702443
92MP0002752_abnormal_somatic_nervous0.83667054
93MP0008775_abnormal_heart_ventricle0.83419003
94MP0005083_abnormal_biliary_tract0.82182904
95MP0002734_abnormal_mechanical_nocicepti0.81048893
96MP0000653_abnormal_sex_gland0.80775642
97MP0010329_abnormal_lipoprotein_level0.80119524
98MP0001764_abnormal_homeostasis0.78292113
99MP0002693_abnormal_pancreas_physiology0.78169366
100MP0001765_abnormal_ion_homeostasis0.77226654

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.03762802
2Abnormality of midbrain morphology (HP:0002418)4.03762802
3Pancreatic cysts (HP:0001737)4.02682018
4Congenital stationary night blindness (HP:0007642)3.94488787
5Attenuation of retinal blood vessels (HP:0007843)3.86484280
6Pancreatic fibrosis (HP:0100732)3.67251091
7Chronic hepatic failure (HP:0100626)3.66357325
8Type II lissencephaly (HP:0007260)3.63326777
9Nephronophthisis (HP:0000090)3.54242857
10True hermaphroditism (HP:0010459)3.38975761
11Abnormal rod and cone electroretinograms (HP:0008323)3.31533505
12Absent/shortened dynein arms (HP:0200106)3.27049840
13Dynein arm defect of respiratory motile cilia (HP:0012255)3.27049840
14Abnormality of the renal medulla (HP:0100957)3.18820272
15Abnormality of the renal cortex (HP:0011035)3.18557352
16Abolished electroretinogram (ERG) (HP:0000550)3.06289987
17Abnormal drinking behavior (HP:0030082)2.92528103
18Polydipsia (HP:0001959)2.92528103
19Medial flaring of the eyebrow (HP:0010747)2.85862284
20Abnormality of alanine metabolism (HP:0010916)2.81922934
21Hyperalaninemia (HP:0003348)2.81922934
22Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.81922934
23Tubular atrophy (HP:0000092)2.80460767
24Bony spicule pigmentary retinopathy (HP:0007737)2.70798168
25Cerebellar dysplasia (HP:0007033)2.65146616
26Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61632955
27Decreased central vision (HP:0007663)2.56938840
28Sclerocornea (HP:0000647)2.47850696
29Cystic liver disease (HP:0006706)2.47774115
30Hypothermia (HP:0002045)2.46822048
31Large for gestational age (HP:0001520)2.46808229
32Polyuria (HP:0000103)2.45034171
33Inability to walk (HP:0002540)2.40568487
34Pendular nystagmus (HP:0012043)2.31409437
35Congenital, generalized hypertrichosis (HP:0004540)2.28982455
36Lissencephaly (HP:0001339)2.28505230
37Abnormal respiratory epithelium morphology (HP:0012253)2.27085020
38Abnormal respiratory motile cilium morphology (HP:0005938)2.27085020
39Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26422544
40Acute necrotizing encephalopathy (HP:0006965)2.24310437
41Optic disc pallor (HP:0000543)2.21738096
42Mitochondrial inheritance (HP:0001427)2.18437686
43Progressive cerebellar ataxia (HP:0002073)2.18030038
44Keratoconus (HP:0000563)2.16125272
45Increased corneal curvature (HP:0100692)2.16125272
46Abnormality of the pons (HP:0007361)2.16034722
47Decreased circulating renin level (HP:0003351)2.15636481
48Retinal dysplasia (HP:0007973)2.14330098
49Abnormal ciliary motility (HP:0012262)2.12993466
50Gait imbalance (HP:0002141)2.12558928
51Progressive inability to walk (HP:0002505)2.11028559
52Congenital hepatic fibrosis (HP:0002612)2.10243626
53Hypoplasia of the pons (HP:0012110)2.09864393
54Increased CSF lactate (HP:0002490)2.09434277
55Hyperventilation (HP:0002883)2.09368075
56Congenital primary aphakia (HP:0007707)2.08979389
57Gaze-evoked nystagmus (HP:0000640)2.08227929
58Renal cortical cysts (HP:0000803)2.06067862
59Abnormal urine output (HP:0012590)2.05630699
60Methylmalonic acidemia (HP:0002912)2.01912865
61Acute encephalopathy (HP:0006846)2.00200600
62Progressive macrocephaly (HP:0004481)1.97760723
63Furrowed tongue (HP:0000221)1.97563142
64Abnormal biliary tract physiology (HP:0012439)1.96555524
65Bile duct proliferation (HP:0001408)1.96555524
66Abnormal mitochondria in muscle tissue (HP:0008316)1.89669499
673-Methylglutaconic aciduria (HP:0003535)1.89272029
68Genetic anticipation (HP:0003743)1.89092938
69Optic nerve hypoplasia (HP:0000609)1.88363449
70Abnormality of macular pigmentation (HP:0008002)1.88000972
71Pachygyria (HP:0001302)1.87766962
72Nephrogenic diabetes insipidus (HP:0009806)1.87761665
73Abnormality of renal excretion (HP:0011036)1.87119225
74Abnormal respiratory motile cilium physiology (HP:0012261)1.87018703
75Male pseudohermaphroditism (HP:0000037)1.86509988
76Anencephaly (HP:0002323)1.86348918
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86209904
78Hemiparesis (HP:0001269)1.85449073
79Hyperglycinuria (HP:0003108)1.84761677
80Patellar aplasia (HP:0006443)1.84531443
81Absent thumb (HP:0009777)1.82638239
82Stomach cancer (HP:0012126)1.81475546
83Hepatocellular necrosis (HP:0001404)1.80409978
84Clumsiness (HP:0002312)1.79906317
85Hepatic necrosis (HP:0002605)1.79652256
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.78912501
87Severe muscular hypotonia (HP:0006829)1.76942768
88Amelogenesis imperfecta (HP:0000705)1.76765407
89Genital tract atresia (HP:0001827)1.75728261
90Concave nail (HP:0001598)1.75554413
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.75388012
92Aplasia/Hypoplasia of the patella (HP:0006498)1.75312243
93Ketosis (HP:0001946)1.75108040
94Increased serum lactate (HP:0002151)1.74280287
95Constricted visual fields (HP:0001133)1.73576613
96Aplasia/Hypoplasia of the tibia (HP:0005772)1.72621846
97Aplasia/hypoplasia of the uterus (HP:0008684)1.71698370
98Abnormality of the renal collecting system (HP:0004742)1.71388537
99Congenital sensorineural hearing impairment (HP:0008527)1.71277490
100Duplicated collecting system (HP:0000081)1.69961442

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.62606286
2BMPR1B3.44755291
3ADRBK23.33283536
4TLK13.31580199
5ZAK3.19178668
6MAP4K22.69587524
7GRK12.64815009
8WNK42.53271638
9INSRR2.51673136
10PINK12.35375923
11TAOK32.24506541
12ACVR1B2.12052926
13WNK32.11515973
14TXK2.06231403
15NUAK12.04479187
16PLK41.98231764
17DAPK21.85427599
18MAPK131.55709239
19MAP3K41.40183514
20STK391.37162135
21OXSR11.30387400
22PLK21.20504571
23MUSK1.18777486
24MAPK151.17124203
25CASK1.15730008
26ADRBK11.14880363
27PNCK1.13329293
28BCKDK1.07618200
29TGFBR11.06262827
30PHKG21.06149773
31PHKG11.06149773
32CAMKK21.02971230
33DYRK20.99613822
34PTK2B0.99115019
35PAK30.96453388
36IKBKB0.94837658
37VRK10.94836622
38MKNK20.94769251
39TNIK0.94101245
40TIE10.87725450
41PRKCG0.87724035
42TRIM280.86652778
43MARK10.83683704
44STK38L0.82470316
45PRKCQ0.80122299
46CDK80.78293740
47PASK0.77100107
48NTRK30.76841497
49MAP2K20.75892667
50MAP2K70.75303516
51CSNK1G20.74959529
52TEC0.74460593
53PRKCE0.73995380
54STK160.73720759
55OBSCN0.71763890
56MAP2K60.67771063
57KIT0.66210823
58RPS6KA50.64887493
59CSNK1G30.63941840
60CSNK1G10.60852570
61MAPKAPK30.59583033
62PIK3CA0.58326892
63CHUK0.57915599
64TAF10.53162583
65PRKCI0.52554624
66ERBB30.49855531
67SYK0.49403559
68PRKACA0.48006329
69CSNK1A1L0.44376943
70CAMK10.44232941
71MAPKAPK50.43893482
72ITK0.43762192
73CAMK2A0.42205213
74GRK60.41859065
75NTRK20.41850920
76STK110.41165126
77PIK3CG0.41072265
78BRSK20.40945723
79SIK20.40096741
80PRKG10.39222447
81PLK30.39014442
82CAMKK10.38448916
83MKNK10.37128265
84PKN10.37124276
85MST40.36440266
86CSNK1D0.35586978
87MAP3K130.34915261
88TNK20.34867956
89NME10.34855232
90PRKCA0.34125217
91MAP4K10.34004330
92PRKAA20.33229797
93CAMK1G0.33174477
94RPS6KA60.32584320
95EIF2AK30.32228324
96CSNK1A10.32206595
97CHEK20.32155282
98PRKCZ0.31041893
99NEK20.29391685
100ATR0.28322555

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.66694304
2Linoleic acid metabolism_Homo sapiens_hsa005912.51574042
3Nitrogen metabolism_Homo sapiens_hsa009102.50374165
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.49009777
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.44337331
6Oxidative phosphorylation_Homo sapiens_hsa001902.38067919
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.37226087
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.36903968
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.26550665
10Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.15872076
11Butanoate metabolism_Homo sapiens_hsa006502.14325685
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.13099471
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.95719587
14Tryptophan metabolism_Homo sapiens_hsa003801.82603691
15Homologous recombination_Homo sapiens_hsa034401.79671084
16Caffeine metabolism_Homo sapiens_hsa002321.78204801
17Nicotine addiction_Homo sapiens_hsa050331.76952564
18Parkinsons disease_Homo sapiens_hsa050121.76657747
19Fanconi anemia pathway_Homo sapiens_hsa034601.71569306
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.66545440
21Selenocompound metabolism_Homo sapiens_hsa004501.65791562
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64296940
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.54897309
24RNA polymerase_Homo sapiens_hsa030201.52381594
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50277238
26Olfactory transduction_Homo sapiens_hsa047401.49924772
27Ether lipid metabolism_Homo sapiens_hsa005651.49800956
28Taste transduction_Homo sapiens_hsa047421.49785580
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38684421
30Basal transcription factors_Homo sapiens_hsa030221.31635572
31Morphine addiction_Homo sapiens_hsa050321.29246965
32Cardiac muscle contraction_Homo sapiens_hsa042601.28621488
33Protein export_Homo sapiens_hsa030601.23793977
34Arachidonic acid metabolism_Homo sapiens_hsa005901.14050770
35Type I diabetes mellitus_Homo sapiens_hsa049401.14049270
36Huntingtons disease_Homo sapiens_hsa050161.13064647
37Propanoate metabolism_Homo sapiens_hsa006401.12910374
38One carbon pool by folate_Homo sapiens_hsa006701.12532420
39RNA degradation_Homo sapiens_hsa030181.10940270
40ABC transporters_Homo sapiens_hsa020101.10042760
41Alzheimers disease_Homo sapiens_hsa050101.07545786
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.07198308
43Asthma_Homo sapiens_hsa053101.07182817
44Peroxisome_Homo sapiens_hsa041461.06792165
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.03941545
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02546461
47Graft-versus-host disease_Homo sapiens_hsa053321.01482568
48Chemical carcinogenesis_Homo sapiens_hsa052040.97814543
49Fatty acid biosynthesis_Homo sapiens_hsa000610.95566730
50Retinol metabolism_Homo sapiens_hsa008300.93607726
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93128929
52Insulin secretion_Homo sapiens_hsa049110.93096245
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.89324584
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.88702555
55Allograft rejection_Homo sapiens_hsa053300.87536013
56Sulfur relay system_Homo sapiens_hsa041220.85149794
57GABAergic synapse_Homo sapiens_hsa047270.84571363
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.84387187
59Regulation of autophagy_Homo sapiens_hsa041400.83506179
60Serotonergic synapse_Homo sapiens_hsa047260.83467914
61Purine metabolism_Homo sapiens_hsa002300.82888219
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81211912
63Circadian entrainment_Homo sapiens_hsa047130.80890390
64beta-Alanine metabolism_Homo sapiens_hsa004100.79774043
65Autoimmune thyroid disease_Homo sapiens_hsa053200.77219466
66Collecting duct acid secretion_Homo sapiens_hsa049660.76310706
67Primary immunodeficiency_Homo sapiens_hsa053400.73980295
68Sulfur metabolism_Homo sapiens_hsa009200.73783738
69Fatty acid degradation_Homo sapiens_hsa000710.72931372
70Ribosome_Homo sapiens_hsa030100.72811484
71Ovarian steroidogenesis_Homo sapiens_hsa049130.72179910
72Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70407616
73Glutamatergic synapse_Homo sapiens_hsa047240.70384319
74Fat digestion and absorption_Homo sapiens_hsa049750.66679314
75Glycerolipid metabolism_Homo sapiens_hsa005610.66289930
76Calcium signaling pathway_Homo sapiens_hsa040200.65826431
77Metabolic pathways_Homo sapiens_hsa011000.62888326
78Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61620442
79Proteasome_Homo sapiens_hsa030500.60261304
80Histidine metabolism_Homo sapiens_hsa003400.58799908
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58611962
82Pyrimidine metabolism_Homo sapiens_hsa002400.55499805
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54822066
84Salivary secretion_Homo sapiens_hsa049700.52517273
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50584744
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49451408
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49204139
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.48929515
89Fatty acid metabolism_Homo sapiens_hsa012120.44884830
90Vitamin digestion and absorption_Homo sapiens_hsa049770.43470371
91SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43049951
92Rheumatoid arthritis_Homo sapiens_hsa053230.42556145
93Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41815601
94Antigen processing and presentation_Homo sapiens_hsa046120.41564492
95Dorso-ventral axis formation_Homo sapiens_hsa043200.40265147
96Non-homologous end-joining_Homo sapiens_hsa034500.36037834
97Mineral absorption_Homo sapiens_hsa049780.34778453
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.34637452
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.34506103
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.33490491

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »