ABHD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1telomere maintenance via semi-conservative replication (GO:0032201)5.15120185
2deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.12053626
3CENP-A containing nucleosome assembly (GO:0034080)5.02287742
4chromatin remodeling at centromere (GO:0031055)4.84777980
5telomere maintenance via recombination (GO:0000722)4.76222450
6regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.71921881
7DNA strand elongation involved in DNA replication (GO:0006271)4.71858127
8mitotic recombination (GO:0006312)4.55088081
9DNA replication checkpoint (GO:0000076)4.54170023
10DNA deamination (GO:0045006)4.50651552
11DNA strand elongation (GO:0022616)4.49960278
12regulation of acyl-CoA biosynthetic process (GO:0050812)4.42020369
13regulation of coenzyme metabolic process (GO:0051196)4.41538478
14regulation of cofactor metabolic process (GO:0051193)4.41538478
15cullin deneddylation (GO:0010388)4.37683985
16histone H2A acetylation (GO:0043968)4.10650437
17DNA replication-independent nucleosome assembly (GO:0006336)4.09650026
18DNA replication-independent nucleosome organization (GO:0034724)4.09650026
19telomere maintenance via telomere lengthening (GO:0010833)4.04546902
20protein deneddylation (GO:0000338)4.03722730
21nucleotide-excision repair, DNA gap filling (GO:0006297)3.89264619
22DNA replication initiation (GO:0006270)3.88498423
23ribosome assembly (GO:0042255)3.88375785
24regulation of sulfur metabolic process (GO:0042762)3.78872270
25histone exchange (GO:0043486)3.78065012
26DNA unwinding involved in DNA replication (GO:0006268)3.77473835
27tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.66155705
28RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.66155705
29ribosomal small subunit assembly (GO:0000028)3.64764236
30protein localization to kinetochore (GO:0034501)3.60728676
31spliceosomal complex assembly (GO:0000245)3.60504608
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59554859
33proteasome assembly (GO:0043248)3.58854251
34DNA ligation (GO:0006266)3.57679130
35postreplication repair (GO:0006301)3.55023579
36sequestering of actin monomers (GO:0042989)3.52329041
37deoxyribonucleotide biosynthetic process (GO:0009263)3.51205549
38kinetochore organization (GO:0051383)3.45830143
39exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.43286708
40kinetochore assembly (GO:0051382)3.40189082
412-deoxyribonucleotide biosynthetic process (GO:0009265)3.39183209
42deoxyribose phosphate biosynthetic process (GO:0046385)3.39183209
43protein K6-linked ubiquitination (GO:0085020)3.35491640
44IMP biosynthetic process (GO:0006188)3.35067420
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.34164638
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31389096
47nuclear pore complex assembly (GO:0051292)3.30010295
48L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.29939425
49anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28477935
50regulation of mitochondrial translation (GO:0070129)3.27891558
51telomere maintenance (GO:0000723)3.26793534
52telomere organization (GO:0032200)3.25279674
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.24922162
54tRNA aminoacylation for protein translation (GO:0006418)3.24391256
55regulation of nuclear cell cycle DNA replication (GO:0033262)3.21927623
56transcription elongation from RNA polymerase III promoter (GO:0006385)3.20847046
57termination of RNA polymerase III transcription (GO:0006386)3.20847046
58nuclear pore organization (GO:0006999)3.20058076
59oxidative phosphorylation (GO:0006119)3.20002760
60attachment of spindle microtubules to kinetochore (GO:0008608)3.17319379
61tRNA aminoacylation (GO:0043039)3.17175951
62amino acid activation (GO:0043038)3.17175951
63viral mRNA export from host cell nucleus (GO:0046784)3.14896579
64mitotic sister chromatid cohesion (GO:0007064)3.14510233
65intra-S DNA damage checkpoint (GO:0031573)3.14273141
66negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.13741840
67negative regulation of ligase activity (GO:0051352)3.13741840
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.12649768
69intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.12649768
70ribonucleoprotein complex disassembly (GO:0032988)3.12358910
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.12098192
72signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.12098192
73signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.12098192
74natural killer cell activation involved in immune response (GO:0002323)3.10271803
75protein localization to chromosome, centromeric region (GO:0071459)3.09281414
76double-strand break repair via nonhomologous end joining (GO:0006303)3.08953083
77non-recombinational repair (GO:0000726)3.08953083
78translesion synthesis (GO:0019985)3.08432424
79antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08207349
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06434780
81formation of translation preinitiation complex (GO:0001731)2.99467260
82signal transduction involved in DNA damage checkpoint (GO:0072422)2.99275823
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99275823
84mitotic metaphase plate congression (GO:0007080)2.97715505
85signal transduction involved in cell cycle checkpoint (GO:0072395)2.96347548
86pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93650518
87pore complex assembly (GO:0046931)2.93501826
88DNA damage response, detection of DNA damage (GO:0042769)2.92735768
89regulation of cellular amino acid metabolic process (GO:0006521)2.92393124
90establishment of chromosome localization (GO:0051303)2.92208129
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.91931067
92regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.90537212
93regulation of mitotic spindle checkpoint (GO:1903504)2.90537212
94G1/S transition of mitotic cell cycle (GO:0000082)2.90536850
95cell cycle G1/S phase transition (GO:0044843)2.90536850
96DNA catabolic process, exonucleolytic (GO:0000738)2.89841935
97regulation of protein heterodimerization activity (GO:0043497)2.89728208
98DNA replication-dependent nucleosome assembly (GO:0006335)2.89086448
99DNA replication-dependent nucleosome organization (GO:0034723)2.89086448
100spliceosomal snRNP assembly (GO:0000387)2.88744384
101pyrimidine nucleotide catabolic process (GO:0006244)2.88156644
102L-methionine salvage (GO:0071267)2.87255201
103L-methionine biosynthetic process (GO:0071265)2.87255201
104amino acid salvage (GO:0043102)2.87255201
105regulation of double-strand break repair via homologous recombination (GO:0010569)2.86731064
106antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.86417737
107establishment of viral latency (GO:0019043)2.85654092
108positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.85492414
109iron-sulfur cluster assembly (GO:0016226)2.84951001
110metallo-sulfur cluster assembly (GO:0031163)2.84951001
111metaphase plate congression (GO:0051310)2.83366626
112DNA double-strand break processing (GO:0000729)2.82070018
113peptidyl-histidine modification (GO:0018202)2.80983650
114IMP metabolic process (GO:0046040)2.80839204
115intraciliary transport (GO:0042073)2.79549439
116organelle disassembly (GO:1903008)2.75007852
117positive regulation of ligase activity (GO:0051351)2.74559116
118nucleobase biosynthetic process (GO:0046112)2.74518611
119transcription-coupled nucleotide-excision repair (GO:0006283)2.73863032
120branched-chain amino acid catabolic process (GO:0009083)2.72924801
121response to pheromone (GO:0019236)2.72746244
122mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72092917
123deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71305153
124mitotic spindle checkpoint (GO:0071174)2.70681955
125purine nucleobase biosynthetic process (GO:0009113)2.70225739
126protein complex biogenesis (GO:0070271)2.69527991
127protein K11-linked ubiquitination (GO:0070979)2.69428204
128establishment of protein localization to mitochondrial membrane (GO:0090151)2.68237629
129purine-containing compound salvage (GO:0043101)2.67546843
130cellular ketone body metabolic process (GO:0046950)2.66842421
131melanosome transport (GO:0032402)2.66596584
132spindle checkpoint (GO:0031577)2.66126182
133establishment of integrated proviral latency (GO:0075713)2.65611061
134negative regulation of sister chromatid segregation (GO:0033046)2.65442766
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.65442766
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65442766
137GMP metabolic process (GO:0046037)2.65280761
138transcription from mitochondrial promoter (GO:0006390)2.62903735
1397-methylguanosine mRNA capping (GO:0006370)2.58897586
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58872096
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58872096
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.58872096
143ubiquinone metabolic process (GO:0006743)2.56724521
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.56152819
145transcription elongation from RNA polymerase I promoter (GO:0006362)2.55299563
146ketone body metabolic process (GO:1902224)2.54101762
147mitochondrial DNA replication (GO:0006264)2.51554198
148aspartate family amino acid biosynthetic process (GO:0009067)2.51413450
1497-methylguanosine RNA capping (GO:0009452)2.50466218
150RNA capping (GO:0036260)2.50466218
151lactate metabolic process (GO:0006089)2.50134819
152replication fork processing (GO:0031297)2.49838547
153chaperone-mediated protein complex assembly (GO:0051131)2.43808878
154regulation of helicase activity (GO:0051095)2.42635085
155mitochondrial RNA metabolic process (GO:0000959)2.41647564
156mitotic spindle assembly checkpoint (GO:0007094)2.39943138
157ubiquinone biosynthetic process (GO:0006744)2.39005228
158spindle assembly checkpoint (GO:0071173)2.36769033
159anterograde synaptic vesicle transport (GO:0048490)2.36406653
160termination of RNA polymerase I transcription (GO:0006363)2.34984785
161positive regulation of mRNA processing (GO:0050685)2.34132590
162ribosomal large subunit biogenesis (GO:0042273)2.33952568
163DNA-dependent DNA replication (GO:0006261)2.33743143
164respiratory chain complex IV assembly (GO:0008535)2.32871341
165synapsis (GO:0007129)2.32794811
166water-soluble vitamin biosynthetic process (GO:0042364)2.32701482
167regulation of sister chromatid segregation (GO:0033045)2.32212289
168regulation of mitotic sister chromatid separation (GO:0010965)2.32212289
169regulation of mitotic sister chromatid segregation (GO:0033047)2.32212289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.36692693
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12321348
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.76091316
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.58699438
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.54690983
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.51917253
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.44268699
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.41272666
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.39708366
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23750863
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.08684028
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.95773734
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67475818
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.67314299
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.66434924
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62709341
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.58839108
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54311664
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.53084965
20VDR_23849224_ChIP-Seq_CD4+_Human2.47328198
21SALL1_21062744_ChIP-ChIP_HESCs_Human2.46344052
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45980332
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43360932
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41476159
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.29433317
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28924676
27* XRN2_22483619_ChIP-Seq_HELA_Human2.28822841
28FOXP3_21729870_ChIP-Seq_TREG_Human2.27372612
29DCP1A_22483619_ChIP-Seq_HELA_Human2.23313102
30HOXB4_20404135_ChIP-ChIP_EML_Mouse2.21406633
31NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16610818
32SRF_21415370_ChIP-Seq_HL-1_Mouse2.15133051
33FUS_26573619_Chip-Seq_HEK293_Human2.14699650
34* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10533876
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04291147
36TTF2_22483619_ChIP-Seq_HELA_Human1.98762917
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.94132312
38ELK1_19687146_ChIP-ChIP_HELA_Human1.92595861
39* GABP_19822575_ChIP-Seq_HepG2_Human1.92157237
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89499650
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86481322
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74795867
43* E2F1_21310950_ChIP-Seq_MCF-7_Human1.74405301
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73061597
45ZNF274_21170338_ChIP-Seq_K562_Hela1.72279311
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72010804
47MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68616232
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67610898
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67450184
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66035832
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.64159556
52VDR_22108803_ChIP-Seq_LS180_Human1.63986413
53* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63588380
54RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.61222686
55SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57996648
56* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57505050
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56942680
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52644021
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51694528
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50148009
61CIITA_25753668_ChIP-Seq_RAJI_Human1.49984260
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.48850123
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48233999
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47687258
65TAF15_26573619_Chip-Seq_HEK293_Human1.45975090
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42869427
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41018593
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.40331097
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40183861
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36815229
71AR_21909140_ChIP-Seq_LNCAP_Human1.34456869
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.34430174
73NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34096602
74IGF1R_20145208_ChIP-Seq_DFB_Human1.33604708
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28495778
76EGR1_19374776_ChIP-ChIP_THP-1_Human1.28493585
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21012858
78MYC_18940864_ChIP-ChIP_HL60_Human1.21007859
79P300_19829295_ChIP-Seq_ESCs_Human1.18017730
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17340704
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.16495244
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.16488679
83GBX2_23144817_ChIP-Seq_PC3_Human1.14444119
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13574338
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11279330
86IRF1_19129219_ChIP-ChIP_H3396_Human1.10239087
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09900013
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08867273
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08332019
90E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05424750
91MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05315665
92CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.05028589
93AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04536732
94KDM5A_27292631_Chip-Seq_BREAST_Human1.04223675
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03749066
96TFEB_21752829_ChIP-Seq_HELA_Human1.01928826
97CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.01426990
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01353643
99CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01339584
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.00628974
101PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00319213
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.00281579
103SPI1_23547873_ChIP-Seq_NB4_Human1.00208278
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99083652
105CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98726145
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98229360
107CBP_20019798_ChIP-Seq_JUKART_Human0.98229360
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97465831
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96519825
110HTT_18923047_ChIP-ChIP_STHdh_Human0.95061583
111REST_19997604_ChIP-ChIP_NEURONS_Mouse0.94542054
112UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94463056
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.94435398
114* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.93294344
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92543545
116* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90360854
117KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90080949
118CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87289159
119SOX2_16153702_ChIP-ChIP_HESCs_Human0.87282903
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.86918017
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86529478
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.85748201
123MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85018614
124* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84805715
125ER_23166858_ChIP-Seq_MCF-7_Human0.84798907
126CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83297057
127SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82885978
128PIAS1_25552417_ChIP-Seq_VCAP_Human0.82779495
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81116549
130CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77547688
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.77126859
132* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76929115
133KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76267794
134CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.74311223
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.73339539
136SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.72430846
137EWS_26573619_Chip-Seq_HEK293_Human0.72002447
138HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.70480157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.83382971
2MP0010094_abnormal_chromosome_stability3.73071518
3MP0008058_abnormal_DNA_repair3.44643804
4MP0003693_abnormal_embryo_hatching3.24250764
5MP0002877_abnormal_melanocyte_morpholog3.03931096
6MP0000569_abnormal_digit_pigmentation3.00756824
7MP0010234_abnormal_vibrissa_follicle2.86671852
8MP0008007_abnormal_cellular_replicative2.78187045
9MP0006292_abnormal_olfactory_placode2.69551411
10MP0003077_abnormal_cell_cycle2.63824384
11MP0004957_abnormal_blastocyst_morpholog2.62196551
12MP0003183_abnormal_peptide_metabolism2.58861439
13MP0008932_abnormal_embryonic_tissue2.51213424
14MP0002638_abnormal_pupillary_reflex2.29706904
15MP0003111_abnormal_nucleus_morphology2.29072917
16MP0008877_abnormal_DNA_methylation2.27952528
17MP0000372_irregular_coat_pigmentation2.16406544
18MP0001986_abnormal_taste_sensitivity2.14193042
19MP0003123_paternal_imprinting2.04202574
20MP0005671_abnormal_response_to1.91694495
21MP0002396_abnormal_hematopoietic_system1.78308613
22MP0009697_abnormal_copulation1.69937311
23MP0001835_abnormal_antigen_presentation1.66978422
24MP0001188_hyperpigmentation1.66523072
25MP0002822_catalepsy1.65822338
26MP0002009_preneoplasia1.64735253
27MP0001984_abnormal_olfaction1.64323044
28MP0001919_abnormal_reproductive_system1.64191984
29MP0005646_abnormal_pituitary_gland1.61348477
30MP0003121_genomic_imprinting1.59852237
31MP0002234_abnormal_pharynx_morphology1.55990784
32MP0003786_premature_aging1.55820762
33MP0006276_abnormal_autonomic_nervous1.53467781
34MP0002090_abnormal_vision1.47921862
35MP0010386_abnormal_urinary_bladder1.44305974
36MP0002095_abnormal_skin_pigmentation1.43588192
37MP0001293_anophthalmia1.42893160
38MP0005389_reproductive_system_phenotype1.35740537
39MP0003763_abnormal_thymus_physiology1.35258047
40MP0005423_abnormal_somatic_nervous1.34086686
41MP0003221_abnormal_cardiomyocyte_apopto1.33666257
42MP0003718_maternal_effect1.32967629
43MP0001764_abnormal_homeostasis1.32034864
44MP0003122_maternal_imprinting1.31523516
45MP0002751_abnormal_autonomic_nervous1.30185000
46MP0002653_abnormal_ependyma_morphology1.27871981
47MP0000631_abnormal_neuroendocrine_gland1.27093236
48MP0009046_muscle_twitch1.24889353
49MP0003195_calcinosis1.23878118
50MP0006072_abnormal_retinal_apoptosis1.23343623
51MP0010678_abnormal_skin_adnexa1.22987976
52MP0002909_abnormal_adrenal_gland1.22663559
53MP0002735_abnormal_chemical_nociception1.20466608
54MP0004133_heterotaxia1.19418312
55MP0002160_abnormal_reproductive_system1.17500794
56MP0000313_abnormal_cell_death1.17442090
57MP0000678_abnormal_parathyroid_gland1.17186863
58MP0000358_abnormal_cell_content/1.14945182
59MP0002837_dystrophic_cardiac_calcinosis1.13811157
60MP0000350_abnormal_cell_proliferation1.12126160
61MP0001905_abnormal_dopamine_level1.10703796
62MP0000427_abnormal_hair_cycle1.09371179
63MP0001727_abnormal_embryo_implantation1.06674504
64MP0002398_abnormal_bone_marrow1.04713967
65MP0004270_analgesia1.02971434
66MP0005367_renal/urinary_system_phenotyp1.02473527
67MP0000516_abnormal_urinary_system1.02473527
68MP0002272_abnormal_nervous_system1.02167992
69MP0002210_abnormal_sex_determination1.02047270
70MP0003943_abnormal_hepatobiliary_system1.01000310
71MP0002132_abnormal_respiratory_system0.98405251
72MP0000490_abnormal_crypts_of0.98392071
73MP0001697_abnormal_embryo_size0.98267410
74MP0005187_abnormal_penis_morphology0.97841013
75MP0005391_vision/eye_phenotype0.96661770
76MP0002102_abnormal_ear_morphology0.95991103
77MP0009785_altered_susceptibility_to0.95838296
78MP0006036_abnormal_mitochondrial_physio0.94479784
79MP0005253_abnormal_eye_physiology0.94392421
80MP0002876_abnormal_thyroid_physiology0.94239600
81MP0005645_abnormal_hypothalamus_physiol0.93738498
82MP0000015_abnormal_ear_pigmentation0.92765410
83MP0000653_abnormal_sex_gland0.91774104
84MP0003880_abnormal_central_pattern0.91625487
85MP0008875_abnormal_xenobiotic_pharmacok0.91467927
86MP0010352_gastrointestinal_tract_polyps0.91340971
87MP0005408_hypopigmentation0.91163429
88MP0003787_abnormal_imprinting0.90781785
89MP0002177_abnormal_outer_ear0.88873921
90MP0001529_abnormal_vocalization0.88431806
91MP0009333_abnormal_splenocyte_physiolog0.88002956
92MP0004197_abnormal_fetal_growth/weight/0.87720105
93MP0002006_tumorigenesis0.87692157
94MP0002148_abnormal_hypersensitivity_rea0.87385390
95MP0004924_abnormal_behavior0.87368153
96MP0005386_behavior/neurological_phenoty0.87368153
97MP0001502_abnormal_circadian_rhythm0.87305468
98MP0001348_abnormal_lacrimal_gland0.87257324
99MP0004215_abnormal_myocardial_fiber0.86982816
100MP0003011_delayed_dark_adaptation0.85817582
101MP0008961_abnormal_basal_metabolism0.85640068
102MP0003937_abnormal_limbs/digits/tail_de0.85558932
103MP0009745_abnormal_behavioral_response0.85454218
104MP0004811_abnormal_neuron_physiology0.85415420
105MP0002019_abnormal_tumor_incidence0.85159499
106MP0005174_abnormal_tail_pigmentation0.85040265
107MP0003186_abnormal_redox_activity0.84897383
108MP0003890_abnormal_embryonic-extraembry0.84488039
109MP0002166_altered_tumor_susceptibility0.83365012
110MP0001730_embryonic_growth_arrest0.83282542
111MP0000647_abnormal_sebaceous_gland0.83133446
112MP0001270_distended_abdomen0.81966832
113MP0002938_white_spotting0.81772007
114MP0005551_abnormal_eye_electrophysiolog0.81620909
115MP0002233_abnormal_nose_morphology0.81543056
116MP0000689_abnormal_spleen_morphology0.81015413
117MP0003698_abnormal_male_reproductive0.80129841
118MP0005084_abnormal_gallbladder_morpholo0.80085953
119MP0000013_abnormal_adipose_tissue0.79015474
120MP0002075_abnormal_coat/hair_pigmentati0.78817364
121MP0009379_abnormal_foot_pigmentation0.78029327
122MP0005085_abnormal_gallbladder_physiolo0.78027316
123MP0003635_abnormal_synaptic_transmissio0.77860853
124MP0005332_abnormal_amino_acid0.77669409
125MP0000703_abnormal_thymus_morphology0.77638712
126MP0006035_abnormal_mitochondrial_morpho0.77020643
127MP0010030_abnormal_orbit_morphology0.76615239
128MP0002429_abnormal_blood_cell0.76347603
129MP0003567_abnormal_fetal_cardiomyocyte0.76240405
130MP0002722_abnormal_immune_system0.76202584
131MP0003646_muscle_fatigue0.76024908
132MP0002063_abnormal_learning/memory/cond0.75694717
133MP0001145_abnormal_male_reproductive0.75678958
134MP0002572_abnormal_emotion/affect_behav0.74897588
135MP0002084_abnormal_developmental_patter0.74774647
136MP0001186_pigmentation_phenotype0.74722674
137MP0004142_abnormal_muscle_tone0.74254360
138MP0002734_abnormal_mechanical_nocicepti0.73783363
139MP0000778_abnormal_nervous_system0.73674939
140MP0000371_diluted_coat_color0.73500311
141MP0001929_abnormal_gametogenesis0.73284311
142MP0002420_abnormal_adaptive_immunity0.72516584
143MP0002080_prenatal_lethality0.71847273
144MP0002184_abnormal_innervation0.71280461
145MP0001819_abnormal_immune_cell0.70749146
146MP0000716_abnormal_immune_system0.70630409
147MP0001853_heart_inflammation0.69919578
148MP0000685_abnormal_immune_system0.66128772
149MP0008995_early_reproductive_senescence0.65060938
150MP0004147_increased_porphyrin_level0.64239588
151MP0001968_abnormal_touch/_nociception0.62944648
152MP0000681_abnormal_thyroid_gland0.62505235
153MP0008789_abnormal_olfactory_epithelium0.62267892

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)4.48499752
2Aplastic anemia (HP:0001915)4.48233589
3Chromsome breakage (HP:0040012)3.58041257
4Abnormal mitochondria in muscle tissue (HP:0008316)3.48670556
5Acute necrotizing encephalopathy (HP:0006965)3.48398131
6Reticulocytopenia (HP:0001896)3.48105220
711 pairs of ribs (HP:0000878)3.43689891
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.40416228
9Hepatocellular necrosis (HP:0001404)3.31045197
10Type I transferrin isoform profile (HP:0003642)3.30579772
11Birth length less than 3rd percentile (HP:0003561)3.28280076
12Abnormal hair whorl (HP:0010721)3.12669074
13Premature graying of hair (HP:0002216)3.10066886
14Mitochondrial inheritance (HP:0001427)3.09303928
15Increased CSF lactate (HP:0002490)3.06558653
16Hypoglycemic coma (HP:0001325)3.05478396
17Hyperinsulinemic hypoglycemia (HP:0000825)3.04390765
18Oral leukoplakia (HP:0002745)3.02428648
19Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99330291
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99330291
21Bone marrow hypocellularity (HP:0005528)2.92920990
22Cortical visual impairment (HP:0100704)2.81262089
23Abnormal delayed hypersensitivity skin test (HP:0002963)2.76023769
24Progressive macrocephaly (HP:0004481)2.72757849
25Renal cortical cysts (HP:0000803)2.68736910
26Nephrogenic diabetes insipidus (HP:0009806)2.67880350
27Meckel diverticulum (HP:0002245)2.59352518
28Hepatic necrosis (HP:0002605)2.57605171
29Hypoglycemic seizures (HP:0002173)2.56689021
30Acute encephalopathy (HP:0006846)2.56435050
31Pancytopenia (HP:0001876)2.56163597
32Aplasia/Hypoplasia of the uvula (HP:0010293)2.55112426
33IgM deficiency (HP:0002850)2.51726234
34Papillary thyroid carcinoma (HP:0002895)2.50945834
35Muscle fiber atrophy (HP:0100295)2.49396462
36Type 2 muscle fiber atrophy (HP:0003554)2.48249271
37Abnormality of glycolysis (HP:0004366)2.47135258
38Abnormality of the ileum (HP:0001549)2.46551117
39Abnormality of chromosome stability (HP:0003220)2.46457177
40Abnormality of the preputium (HP:0100587)2.41870738
41Cortical dysplasia (HP:0002539)2.40919110
42Volvulus (HP:0002580)2.36584101
43Increased serum pyruvate (HP:0003542)2.36226117
44Abnormality of the anterior horn cell (HP:0006802)2.35762400
45Degeneration of anterior horn cells (HP:0002398)2.35762400
46Exertional dyspnea (HP:0002875)2.32665647
47Methylmalonic acidemia (HP:0002912)2.31906056
48Increased serum lactate (HP:0002151)2.29803598
49Neoplasm of the adrenal gland (HP:0100631)2.29081275
50Muscular hypotonia of the trunk (HP:0008936)2.28832970
51Abnormality of methionine metabolism (HP:0010901)2.26937177
52Abnormality of T cell physiology (HP:0011840)2.26504720
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.25035547
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.25035547
55Exercise intolerance (HP:0003546)2.24557319
56True hermaphroditism (HP:0010459)2.23166864
57Ketoacidosis (HP:0001993)2.19560697
58Atrophy/Degeneration involving motor neurons (HP:0007373)2.19043193
59Thyroid carcinoma (HP:0002890)2.16194782
60Prominent metopic ridge (HP:0005487)2.12350103
61Hypsarrhythmia (HP:0002521)2.11549643
62Patellar aplasia (HP:0006443)2.10595302
63Abnormal number of incisors (HP:0011064)2.10325844
64Abnormality of endocrine pancreas physiology (HP:0012093)2.09431775
65Abnormality of the pancreatic islet cells (HP:0006476)2.09431775
66Abnormality of the renal collecting system (HP:0004742)2.09266653
67Pancreatic islet-cell hyperplasia (HP:0004510)2.08487162
68Cutaneous melanoma (HP:0012056)2.07129972
69Reduced antithrombin III activity (HP:0001976)2.05453800
70Abnormality of alanine metabolism (HP:0010916)2.05072903
71Hyperalaninemia (HP:0003348)2.05072903
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05072903
73Increased hepatocellular lipid droplets (HP:0006565)2.03823593
74Postnatal microcephaly (HP:0005484)2.03170511
75Medial flaring of the eyebrow (HP:0010747)2.02986936
76Progressive inability to walk (HP:0002505)2.02976432
77Fibular hypoplasia (HP:0003038)2.02723958
78Abnormal glycosylation (HP:0012345)2.02620433
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.02620433
80Abnormal protein N-linked glycosylation (HP:0012347)2.02620433
81Abnormal protein glycosylation (HP:0012346)2.02620433
82EEG with generalized epileptiform discharges (HP:0011198)2.02435572
83Myelodysplasia (HP:0002863)2.02144108
84Rough bone trabeculation (HP:0100670)2.02068597
85Cerebral edema (HP:0002181)2.01224971
86Genital tract atresia (HP:0001827)2.00390504
87Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99418467
88Progressive neurologic deterioration (HP:0002344)1.96831408
89Renal Fanconi syndrome (HP:0001994)1.96623017
90Epileptiform EEG discharges (HP:0011182)1.95553369
91Abnormality of the metopic suture (HP:0005556)1.94439248
92Vaginal atresia (HP:0000148)1.94343275
93Febrile seizures (HP:0002373)1.92897193
94Poor coordination (HP:0002370)1.92375050
95Cellular immunodeficiency (HP:0005374)1.92167727
96Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.91336971
97Colon cancer (HP:0003003)1.90892355
98Irregular epiphyses (HP:0010582)1.90167709
99Abnormality of the corticospinal tract (HP:0002492)1.89424157
100Thyroid-stimulating hormone excess (HP:0002925)1.89071743
101Neoplasm of the adrenal cortex (HP:0100641)1.88333932
102Abnormality of the labia minora (HP:0012880)1.88037697
103Duplicated collecting system (HP:0000081)1.87740939
104Aplasia/Hypoplasia of the patella (HP:0006498)1.87516080
105Selective tooth agenesis (HP:0001592)1.87475068
106Abnormality of cells of the erythroid lineage (HP:0012130)1.86351301
107Poor head control (HP:0002421)1.84347126
108Severe visual impairment (HP:0001141)1.83556017
109Failure to thrive in infancy (HP:0001531)1.83276504
110Pancreatic fibrosis (HP:0100732)1.81682197
111Pallor (HP:0000980)1.81367193
112Hyperglycemia (HP:0003074)1.80943851
113Lactic acidosis (HP:0003128)1.80930964
1143-Methylglutaconic aciduria (HP:0003535)1.79487321
115Rimmed vacuoles (HP:0003805)1.79393611
116Abnormal number of erythroid precursors (HP:0012131)1.79259082
117Specific learning disability (HP:0001328)1.78826062
118Acute lymphatic leukemia (HP:0006721)1.78358112
119Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.78163148
120Lipid accumulation in hepatocytes (HP:0006561)1.78161126
121Hypoplasia of the fovea (HP:0007750)1.77781586
122Aplasia/Hypoplasia of the fovea (HP:0008060)1.77781586
123Sloping forehead (HP:0000340)1.76912275
124Sleep apnea (HP:0010535)1.76560773
125Congenital primary aphakia (HP:0007707)1.76287180
126Neuroendocrine neoplasm (HP:0100634)1.76279161
127Respiratory difficulties (HP:0002880)1.75852404
128Brushfield spots (HP:0001088)1.75716719
129Elevated erythrocyte sedimentation rate (HP:0003565)1.74996108
130Hypoplasia of the pons (HP:0012110)1.74583221
131Gait imbalance (HP:0002141)1.74369717
132Pheochromocytoma (HP:0002666)1.73240234
133Adrenal hypoplasia (HP:0000835)1.72784801
134Leukodystrophy (HP:0002415)1.72085242
135Poor suck (HP:0002033)1.71160542
136Medulloblastoma (HP:0002885)1.70576050
137Abnormality of the renal cortex (HP:0011035)1.70560346
138Ketosis (HP:0001946)1.70405060
139Optic nerve coloboma (HP:0000588)1.70022780
140Increased intramyocellular lipid droplets (HP:0012240)1.69928518
141Nephroblastoma (Wilms tumor) (HP:0002667)1.69912882
142Short tibia (HP:0005736)1.69900823
143Pancreatic cysts (HP:0001737)1.69365985
144Lymphoma (HP:0002665)1.68515446
145Abnormality of the heme biosynthetic pathway (HP:0010472)1.67921093
146Self-mutilation (HP:0000742)1.67482229
147Microvesicular hepatic steatosis (HP:0001414)1.66946676
148Small intestinal stenosis (HP:0012848)1.66174632
149Duodenal stenosis (HP:0100867)1.66174632
150Tubulointerstitial nephritis (HP:0001970)1.66080480
151Broad foot (HP:0001769)1.64889400
152Abnormality of midbrain morphology (HP:0002418)1.61521225
153Molar tooth sign on MRI (HP:0002419)1.61521225
154Abnormality of aspartate family amino acid metabolism (HP:0010899)1.60595107
155Menstrual irregularities (HP:0000858)1.60518429
156Hyperglycinemia (HP:0002154)1.60360750
157Respiratory failure (HP:0002878)1.59617369
158Decreased testicular size (HP:0008734)1.59387363
159Impaired vibration sensation in the lower limbs (HP:0002166)1.58447188
160Retinal dysplasia (HP:0007973)1.58134417

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST43.97821885
2SRPK13.61104694
3TESK13.37495806
4MAP4K23.26155620
5EIF2AK13.13348582
6STK163.09020277
7TLK12.99379816
8WEE12.87984119
9SCYL22.80530598
10NEK12.62090462
11LIMK12.61944682
12SIK32.59182672
13TRIM282.59012421
14MAP3K122.50663064
15ACVR1B2.48445406
16CDC72.31362681
17BRSK22.25787513
18BUB12.25371324
19ERBB32.21464194
20MAP3K42.19140712
21CCNB12.14507397
22FLT32.13141350
23MST1R2.08601999
24MAP2K71.94579211
25EIF2AK31.91226076
26STK391.88323807
27NUAK11.72954384
28FRK1.70233291
29TESK21.67268184
30MKNK11.64841996
31MKNK21.63082887
32TNIK1.62261295
33CDK191.49231202
34VRK11.43335818
35CASK1.39614595
36PLK11.37322973
37UHMK11.36431127
38BRSK11.35075967
39WNK41.29748048
40ZAK1.24866429
41TAF11.21811656
42TSSK61.19721101
43NME21.12513448
44PLK21.11160776
45MAP2K41.10141926
46WNK31.09455770
47ATR1.07626548
48YES11.05759771
49CSNK1A1L1.05739335
50PRPF4B1.05209386
51KIT1.04458182
52MET1.00643720
53PBK0.99044229
54CSNK1G20.99024861
55CSNK1G30.98470451
56PNCK0.97751895
57CDK80.95414018
58TAOK20.94932206
59EIF2AK20.94367253
60INSRR0.93001036
61PLK40.91350353
62AURKA0.90967609
63MARK10.89987255
64PINK10.89033918
65AKT30.87827144
66BMPR1B0.87634493
67IRAK40.87360643
68CSF1R0.85823112
69BMPR20.85450728
70DAPK10.84419163
71BRD40.84329275
72BRAF0.83807568
73NEK20.83576261
74CSNK1G10.82314747
75PLK30.77442436
76MAPK130.76701189
77CAMKK20.74567100
78OXSR10.74436000
79VRK20.74276100
80IKBKE0.73429492
81AURKB0.70747461
82TEC0.68498266
83CDK70.68344005
84CDK180.67988959
85PASK0.66275235
86DYRK30.64760337
87MINK10.63659214
88PAK30.62787653
89NTRK30.62785498
90RPS6KA40.62519204
91PRKCE0.61727822
92STK38L0.59485625
93TTK0.59095436
94PIM20.58232929
95ERBB40.58114000
96FGFR10.57786601
97PRKCG0.56476640
98MAP3K110.56429295
99RPS6KB10.55115623
100CDK11A0.54635203
101CDK150.53844895
102CDK140.51089983
103TGFBR10.50148612
104TXK0.47769423
105CSNK2A10.47580720
106BCKDK0.46578517
107CSNK2A20.45850716
108EPHA40.45703575
109KSR10.45111301
110CHEK10.44720400
111BCR0.44284294
112MUSK0.43156612
113DYRK1A0.42877628
114ADRBK20.41395494
115CDK30.40574085
116CAMK40.39942946
117AKT20.39230542
118MAP3K50.39209870
119CHEK20.38043920
120MAPKAPK30.37773865
121DYRK20.37617585
122BTK0.36513377
123CSNK1E0.36466057
124MAP3K60.36372802
125RPS6KA50.36055915
126CLK10.35650450
127STK30.35391949
128RPS6KA60.33204368
129NEK60.33132539
130MAP4K10.31372786
131PIK3CA0.31182138
132CDK10.30672456
133ATM0.30124352
134STK40.29266597
135RPS6KC10.28488822
136RPS6KL10.28488822
137CSNK1D0.28391372
138TNK20.27715393
139FGFR20.26600269
140CDK20.25334501
141RPS6KA20.23570904
142NME10.22338538
143CAMK10.21690838

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.94093358
2Proteasome_Homo sapiens_hsa030504.06547476
3Homologous recombination_Homo sapiens_hsa034403.86215443
4Mismatch repair_Homo sapiens_hsa034303.72542158
5Ribosome_Homo sapiens_hsa030102.85866867
6Base excision repair_Homo sapiens_hsa034102.84085120
7RNA polymerase_Homo sapiens_hsa030202.82190390
8Spliceosome_Homo sapiens_hsa030402.81586066
9Fanconi anemia pathway_Homo sapiens_hsa034602.64742945
10Non-homologous end-joining_Homo sapiens_hsa034502.45308652
11Nucleotide excision repair_Homo sapiens_hsa034202.39606027
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.33994132
13Pyrimidine metabolism_Homo sapiens_hsa002402.33737919
14Cell cycle_Homo sapiens_hsa041102.29802577
15Propanoate metabolism_Homo sapiens_hsa006402.28782716
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16664181
17Protein export_Homo sapiens_hsa030602.11346640
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02069138
19Butanoate metabolism_Homo sapiens_hsa006501.85522831
20RNA degradation_Homo sapiens_hsa030181.83293361
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.80110172
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78315051
23Basal transcription factors_Homo sapiens_hsa030221.77309779
24RNA transport_Homo sapiens_hsa030131.74501616
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69854952
26Fatty acid elongation_Homo sapiens_hsa000621.65132970
27Parkinsons disease_Homo sapiens_hsa050121.63749576
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.59428866
29Oxidative phosphorylation_Homo sapiens_hsa001901.56108813
30Purine metabolism_Homo sapiens_hsa002301.54726576
31Regulation of autophagy_Homo sapiens_hsa041401.44838008
32Pyruvate metabolism_Homo sapiens_hsa006201.33689728
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31120397
34Huntingtons disease_Homo sapiens_hsa050161.27753306
35Selenocompound metabolism_Homo sapiens_hsa004501.25148139
36One carbon pool by folate_Homo sapiens_hsa006701.23677204
37Peroxisome_Homo sapiens_hsa041461.23363367
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19565261
39Vitamin B6 metabolism_Homo sapiens_hsa007501.17607969
40p53 signaling pathway_Homo sapiens_hsa041151.17215939
41N-Glycan biosynthesis_Homo sapiens_hsa005101.15492885
42Sulfur metabolism_Homo sapiens_hsa009201.14555043
43Epstein-Barr virus infection_Homo sapiens_hsa051691.10564224
44Carbon metabolism_Homo sapiens_hsa012001.09763556
45Herpes simplex infection_Homo sapiens_hsa051681.08451964
46mRNA surveillance pathway_Homo sapiens_hsa030151.07082545
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01847005
48Oocyte meiosis_Homo sapiens_hsa041141.01492957
49Circadian rhythm_Homo sapiens_hsa047100.97661631
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97244189
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95794362
52Fatty acid metabolism_Homo sapiens_hsa012120.92697985
53Alcoholism_Homo sapiens_hsa050340.91902527
54Alzheimers disease_Homo sapiens_hsa050100.91551259
55Biosynthesis of amino acids_Homo sapiens_hsa012300.90975741
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89751693
57beta-Alanine metabolism_Homo sapiens_hsa004100.89413171
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88001569
59Thyroid cancer_Homo sapiens_hsa052160.83371022
60Glutathione metabolism_Homo sapiens_hsa004800.81978133
61Systemic lupus erythematosus_Homo sapiens_hsa053220.81615134
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79571589
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79389194
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79190562
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78617677
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78144129
67Fatty acid degradation_Homo sapiens_hsa000710.76695106
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.75476922
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74605940
70Legionellosis_Homo sapiens_hsa051340.73421753
71Folate biosynthesis_Homo sapiens_hsa007900.71349252
72Synaptic vesicle cycle_Homo sapiens_hsa047210.70724130
73Type I diabetes mellitus_Homo sapiens_hsa049400.70021259
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67766473
75Steroid biosynthesis_Homo sapiens_hsa001000.67405155
76Caffeine metabolism_Homo sapiens_hsa002320.67017985
77Allograft rejection_Homo sapiens_hsa053300.66673436
78Olfactory transduction_Homo sapiens_hsa047400.66394489
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64129244
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61438382
81Arginine and proline metabolism_Homo sapiens_hsa003300.60824408
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60634580
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59405193
84Viral carcinogenesis_Homo sapiens_hsa052030.58939843
85Cardiac muscle contraction_Homo sapiens_hsa042600.58579158
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56470429
87Hepatitis B_Homo sapiens_hsa051610.55562778
88Galactose metabolism_Homo sapiens_hsa000520.55404966
89Phototransduction_Homo sapiens_hsa047440.55251842
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53702880
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52753081
92Primary immunodeficiency_Homo sapiens_hsa053400.50974851
93Vibrio cholerae infection_Homo sapiens_hsa051100.50891071
94Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47707590
95Measles_Homo sapiens_hsa051620.47554266
96Tryptophan metabolism_Homo sapiens_hsa003800.45051238
97Influenza A_Homo sapiens_hsa051640.44991796
98Taste transduction_Homo sapiens_hsa047420.44853681
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44144109
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43513245
101Fatty acid biosynthesis_Homo sapiens_hsa000610.43279129
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.41314624
103Nicotine addiction_Homo sapiens_hsa050330.41240226
104Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40991795
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39853083
106Cocaine addiction_Homo sapiens_hsa050300.39707682
107Antigen processing and presentation_Homo sapiens_hsa046120.39137728
108Phenylalanine metabolism_Homo sapiens_hsa003600.39106646
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38592024
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37775517
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.36954764
112Shigellosis_Homo sapiens_hsa051310.36449782
113Hematopoietic cell lineage_Homo sapiens_hsa046400.35817529
114HTLV-I infection_Homo sapiens_hsa051660.34673117
115Morphine addiction_Homo sapiens_hsa050320.34530971
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.34356637
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34302506
118NF-kappa B signaling pathway_Homo sapiens_hsa040640.33490834
119GABAergic synapse_Homo sapiens_hsa047270.32049418
120Ether lipid metabolism_Homo sapiens_hsa005650.31950849
121Nitrogen metabolism_Homo sapiens_hsa009100.31858397
122Tyrosine metabolism_Homo sapiens_hsa003500.31722339
123Fructose and mannose metabolism_Homo sapiens_hsa000510.31161853
124Autoimmune thyroid disease_Homo sapiens_hsa053200.31085099
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31039897
126Hedgehog signaling pathway_Homo sapiens_hsa043400.29245589
127Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28926121
128Colorectal cancer_Homo sapiens_hsa052100.28561632
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.26350695
130Serotonergic synapse_Homo sapiens_hsa047260.26333221
131Cysteine and methionine metabolism_Homo sapiens_hsa002700.26054628
132Apoptosis_Homo sapiens_hsa042100.25247335
133Circadian entrainment_Homo sapiens_hsa047130.24082876
134Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.23796304
135Pentose phosphate pathway_Homo sapiens_hsa000300.23546543
136Asthma_Homo sapiens_hsa053100.23133875
137Dopaminergic synapse_Homo sapiens_hsa047280.22835303
138Phagosome_Homo sapiens_hsa041450.20891590
139NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19776977
140Acute myeloid leukemia_Homo sapiens_hsa052210.19501779
141Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18484041
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17870384
143Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.17688299
144Leishmaniasis_Homo sapiens_hsa051400.17504117
145Metabolic pathways_Homo sapiens_hsa011000.16727763
146Maturity onset diabetes of the young_Homo sapiens_hsa049500.16398873
147Collecting duct acid secretion_Homo sapiens_hsa049660.14760598

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