ABHD12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the hydrolysis of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid transmitter that acts on cannabinoid receptors, CB1 and CB2. The endocannabinoid system is involved in a wide range of physiological processes, including neurotransmission, mood, appetite, pain appreciation, addiction behavior, and inflammation. Mutations in this gene are associated with the neurodegenerative disease, PHARC (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract), resulting from an inborn error of endocannabinoid metabolism. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.35598938
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.04474187
3glycosphingolipid catabolic process (GO:0046479)4.96447572
4locomotory exploration behavior (GO:0035641)4.73018779
5glycolipid catabolic process (GO:0019377)4.52220369
6synaptic vesicle exocytosis (GO:0016079)4.49938892
7barbed-end actin filament capping (GO:0051016)4.46714982
8oligosaccharide catabolic process (GO:0009313)4.33873259
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.27845690
10cellular potassium ion homeostasis (GO:0030007)4.26843658
11cellular response to thyroid hormone stimulus (GO:0097067)4.25193575
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.24266041
13sodium ion export (GO:0071436)4.23255766
14glutamate secretion (GO:0014047)4.19135664
15amino sugar catabolic process (GO:0046348)4.16534629
16regulation of synaptic vesicle exocytosis (GO:2000300)4.14347493
17protein localization to endosome (GO:0036010)4.13760070
18regulation of synapse structural plasticity (GO:0051823)4.10998345
19synaptic vesicle docking involved in exocytosis (GO:0016081)3.93968731
20adhesion of symbiont to host cell (GO:0044650)3.90591248
21virion attachment to host cell (GO:0019062)3.90591248
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.90520245
23adhesion of symbiont to host (GO:0044406)3.90244906
24vocalization behavior (GO:0071625)3.79265745
25regulation of glutamate receptor signaling pathway (GO:1900449)3.77255181
26neuronal action potential propagation (GO:0019227)3.76833335
27ceramide catabolic process (GO:0046514)3.76654862
28regulation of mononuclear cell migration (GO:0071675)3.75030882
29regulation of synaptic vesicle transport (GO:1902803)3.74746363
30regulation of neuronal synaptic plasticity (GO:0048168)3.64682859
31response to thyroid hormone (GO:0097066)3.64124471
32regulation of cholesterol storage (GO:0010885)3.61234265
33proline transport (GO:0015824)3.59775571
34membrane lipid catabolic process (GO:0046466)3.58581652
35L-amino acid import (GO:0043092)3.57197104
36ionotropic glutamate receptor signaling pathway (GO:0035235)3.57083917
37neurotransmitter secretion (GO:0007269)3.56686523
38sphingolipid catabolic process (GO:0030149)3.49196758
39regulation of early endosome to late endosome transport (GO:2000641)3.49107161
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.48524771
41regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46698963
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43428407
43negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.40444736
44exploration behavior (GO:0035640)3.39792366
45negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.38529509
46protein retention in ER lumen (GO:0006621)3.37916733
47regulation of ARF protein signal transduction (GO:0032012)3.36432690
48layer formation in cerebral cortex (GO:0021819)3.31314190
49apoptotic cell clearance (GO:0043277)3.25306087
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.22215631
51activation of protein kinase A activity (GO:0034199)3.21763623
52N-acetylneuraminate metabolic process (GO:0006054)3.21350357
53protein localization to synapse (GO:0035418)3.19046644
54neuromuscular process controlling balance (GO:0050885)3.18232096
55gamma-aminobutyric acid transport (GO:0015812)3.15520273
56COPI coating of Golgi vesicle (GO:0048205)3.15110708
57Golgi transport vesicle coating (GO:0048200)3.15110708
58long-term memory (GO:0007616)3.15070158
59glycine transport (GO:0015816)3.14861485
60positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.14807002
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.12582766
62potassium ion homeostasis (GO:0055075)3.12015506
63amyloid precursor protein catabolic process (GO:0042987)3.11930685
64response to peptidoglycan (GO:0032494)3.11895475
65neuromuscular process controlling posture (GO:0050884)3.10783027
66maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.09752732
67regulation of macrophage chemotaxis (GO:0010758)3.07648855
68response to acidic pH (GO:0010447)3.06783830
69glutamate receptor signaling pathway (GO:0007215)3.06652946
70low-density lipoprotein particle clearance (GO:0034383)3.06548515
71potassium ion import (GO:0010107)3.05073028
72neurotransmitter-gated ion channel clustering (GO:0072578)3.05062441
73cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.01733667
74pinocytosis (GO:0006907)2.99815095
75synaptic transmission, glutamatergic (GO:0035249)2.98839837
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.97603709
77amino acid import (GO:0043090)2.96320444
78negative regulation of interleukin-12 production (GO:0032695)2.95996321
79regulation of synaptic plasticity (GO:0048167)2.94723007
80alanine transport (GO:0032328)2.93987237
81cellular sodium ion homeostasis (GO:0006883)2.93628590
82regulation of excitatory postsynaptic membrane potential (GO:0060079)2.93434931
83negative regulation of erythrocyte differentiation (GO:0045647)2.91802117
84neurotransmitter transport (GO:0006836)2.91639482
85regulation of clathrin-mediated endocytosis (GO:2000369)2.90284409
86ganglioside metabolic process (GO:0001573)2.89180934
87lipopolysaccharide-mediated signaling pathway (GO:0031663)2.85442786
88modulation by symbiont of host cellular process (GO:0044068)2.84742788
89vesicle transport along microtubule (GO:0047496)2.83922967
90transferrin transport (GO:0033572)2.83533067
91neuron-neuron synaptic transmission (GO:0007270)2.82691755
92dendritic spine morphogenesis (GO:0060997)2.82430348
93long-term synaptic potentiation (GO:0060291)2.80951303
94cell communication by electrical coupling (GO:0010644)2.80913852
95synaptic vesicle endocytosis (GO:0048488)2.80356156
96stress fiber assembly (GO:0043149)2.79975799
97neuron cell-cell adhesion (GO:0007158)2.79062457
98positive regulation of leukocyte degranulation (GO:0043302)2.78192130
99nerve growth factor signaling pathway (GO:0038180)2.78122321
100regulation of neurotransmitter levels (GO:0001505)2.77682457
101regulation of postsynaptic membrane potential (GO:0060078)2.76772792
102regulation of cholesterol esterification (GO:0010872)2.75864380
103positive regulation of membrane potential (GO:0045838)2.74198688
104NIK/NF-kappaB signaling (GO:0038061)2.73901597
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73546285
106positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73488596
107glial cell migration (GO:0008347)2.71406723
108microglial cell activation (GO:0001774)2.71125478
109regulation of amyloid precursor protein catabolic process (GO:1902991)2.69036368
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67452130
111mating behavior (GO:0007617)2.67085464
112regulation of superoxide anion generation (GO:0032928)2.66866480
113endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.66674416
114cyclooxygenase pathway (GO:0019371)2.65647476
115regulation of membrane protein ectodomain proteolysis (GO:0051043)2.65151355
116regulation of synaptic transmission, glutamatergic (GO:0051966)2.64651434
117regulation of beta-amyloid formation (GO:1902003)2.64305316
118cerebellar Purkinje cell layer development (GO:0021680)2.62977125
119gamma-aminobutyric acid signaling pathway (GO:0007214)2.62899683
120regulation of neurotransmitter secretion (GO:0046928)2.62580965
121adenosine receptor signaling pathway (GO:0001973)2.62560716
122cellular response to arsenic-containing substance (GO:0071243)2.61265028
123prepulse inhibition (GO:0060134)2.61017105
124regulation of dendritic spine morphogenesis (GO:0061001)2.60519855
125hyaluronan catabolic process (GO:0030214)2.60003765
126cell-cell junction maintenance (GO:0045217)2.59595548
127mannose metabolic process (GO:0006013)2.59593128
128regulation of podosome assembly (GO:0071801)2.58877393
129positive regulation of cholesterol efflux (GO:0010875)2.57976180
130dendrite morphogenesis (GO:0048813)2.57267425
131glucose 6-phosphate metabolic process (GO:0051156)2.57023321
132transmission of nerve impulse (GO:0019226)2.54792127
133clathrin coat assembly (GO:0048268)2.54449891
134activation of MAPKKK activity (GO:0000185)2.53751293
135retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.52629831
136regulation of extracellular matrix disassembly (GO:0010715)2.52351773
137macrophage activation involved in immune response (GO:0002281)2.52221419
138regulation of ARF GTPase activity (GO:0032312)2.51576806
139angiotensin maturation (GO:0002003)2.51427807
140phagosome maturation (GO:0090382)2.50559050
141membrane depolarization (GO:0051899)2.50553571
142trivalent inorganic cation transport (GO:0072512)2.50539740
143ferric iron transport (GO:0015682)2.50539740
144positive regulation of synaptic transmission (GO:0050806)2.50101558
145T-helper 1 type immune response (GO:0042088)2.50101174
146membrane depolarization during action potential (GO:0086010)2.49766620
147negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.49556580
148positive regulation of extracellular matrix organization (GO:1903055)2.49209644
149cerebellar Purkinje cell differentiation (GO:0021702)2.49190609
150cellular copper ion homeostasis (GO:0006878)2.48738425
151myeloid dendritic cell differentiation (GO:0043011)2.48709504
152regulation of vesicle fusion (GO:0031338)2.48651623
153bone resorption (GO:0045453)2.47550180
154regulation of leukocyte degranulation (GO:0043300)2.47359062
155lytic vacuole organization (GO:0080171)2.47304278
156lysosome organization (GO:0007040)2.47304278
157positive regulation of cellular amide metabolic process (GO:0034250)2.46335784
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.45028557
159regulation of neurotransmitter transport (GO:0051588)2.44952034
160positive regulation of monocyte chemotaxis (GO:0090026)2.42316119
161regulation of synaptic transmission (GO:0050804)2.42153698
162positive regulation of chemokine biosynthetic process (GO:0045080)2.42126752
163decidualization (GO:0046697)2.42118402
164neuromuscular process (GO:0050905)2.41960955
165regulation of dendritic spine development (GO:0060998)2.41918380
166semaphorin-plexin signaling pathway (GO:0071526)2.40869085
167membrane repolarization (GO:0086009)2.40511435
168regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.40224428
169positive regulation of neurotransmitter transport (GO:0051590)2.39527085
170negative regulation of amino acid transport (GO:0051956)2.38634866
171negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38328069
172regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.38261260
173membrane hyperpolarization (GO:0060081)2.37771941
174fat-soluble vitamin biosynthetic process (GO:0042362)2.36824392
175regulation of voltage-gated calcium channel activity (GO:1901385)2.36733343
176serine transport (GO:0032329)2.36001885
177plasma lipoprotein particle clearance (GO:0034381)2.35143849
178positive regulation of potassium ion transmembrane transport (GO:1901381)2.34560197
179positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.33840734
180oligosaccharide metabolic process (GO:0009311)2.33671292
181positive regulation of neurotransmitter secretion (GO:0001956)2.33544729
182negative regulation of nitric oxide biosynthetic process (GO:0045019)2.31999692
183receptor catabolic process (GO:0032801)2.31484517
184positive regulation of Cdc42 GTPase activity (GO:0043089)2.29890724
185monocyte chemotaxis (GO:0002548)2.28656824
186branching involved in labyrinthine layer morphogenesis (GO:0060670)2.27872680
187regulation of cholesterol biosynthetic process (GO:0045540)2.26890959
188regulation of hydrogen peroxide-induced cell death (GO:1903205)2.25355625
189dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.22934141

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.99048037
2NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.61097560
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.78931877
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74924995
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68613770
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.61635267
7DROSHA_22980978_ChIP-Seq_HELA_Human2.57318588
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.56308262
9MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44413027
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41997524
11IKZF1_21737484_ChIP-ChIP_HCT116_Human2.41685352
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36550170
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.35938920
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34122797
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34100429
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34100429
17VDR_21846776_ChIP-Seq_THP-1_Human2.30561505
18ELK3_25401928_ChIP-Seq_HUVEC_Human2.21754097
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.21276284
20GBX2_23144817_ChIP-Seq_PC3_Human2.20678869
21REST_21632747_ChIP-Seq_MESCs_Mouse2.20049209
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.17876841
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17346875
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16687627
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.09269455
26RACK7_27058665_Chip-Seq_MCF-7_Human2.08320783
27ZNF263_19887448_ChIP-Seq_K562_Human1.97672436
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.95444281
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95216494
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92201779
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.87786102
32SRY_22984422_ChIP-ChIP_TESTIS_Rat1.87595314
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.85064967
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.82202400
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.77642128
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77221512
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.71322977
38EED_16625203_ChIP-ChIP_MESCs_Mouse1.66748828
39NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64916592
40ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62544964
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.62106341
42CLOCK_20551151_ChIP-Seq_293T_Human1.59525890
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.56837445
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.56492847
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55847895
46VDR_24763502_ChIP-Seq_THP-1_Human1.55380096
47THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54160747
48VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.53996705
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.52446704
50AR_21572438_ChIP-Seq_LNCaP_Human1.51009678
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.48970986
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.48448558
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46502620
54KDM2B_26808549_Chip-Seq_K562_Human1.45892347
55TCF7_22412390_ChIP-Seq_EML_Mouse1.42912404
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.42262979
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.42128512
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41006766
59SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39887662
60NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38088445
61P68_20966046_ChIP-Seq_HELA_Human1.38053353
62SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37516319
63RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37416139
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37035185
65TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36849938
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33806012
67* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32197108
68RXR_22158963_ChIP-Seq_LIVER_Mouse1.32156464
69MYC_22102868_ChIP-Seq_BL_Human1.31306702
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.29546857
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.29241362
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28813352
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28333885
74RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28220202
75SA1_27219007_Chip-Seq_ERYTHROID_Human1.27232499
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.26425184
77DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25453598
78CTCF_27219007_Chip-Seq_ERYTHROID_Human1.24349455
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24085807
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21880443
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.20548016
82SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19573432
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19406485
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18980216
85CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17411075
86TP53_22127205_ChIP-Seq_IMR90_Human1.17080425
87BCOR_27268052_Chip-Seq_Bcells_Human1.17072043
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16648499
89EGR1_19374776_ChIP-ChIP_THP-1_Human1.16617549
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16249161
91PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15689985
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14539826
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.14247807
94ESR1_21235772_ChIP-Seq_MCF-7_Human1.13185237
95CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12945177
96* SMAD4_21799915_ChIP-Seq_A2780_Human1.12841466
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12677512
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12578000
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.11929971
100IRF8_22096565_ChIP-ChIP_GC-B_Human1.11334169
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.11095653
102ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10216128
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10172851
104AHR_22903824_ChIP-Seq_MCF-7_Human1.10162914
105* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09937875
106BCL6_27268052_Chip-Seq_Bcells_Human1.09428990
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09289963
108LXR_22292898_ChIP-Seq_THP-1_Human1.09254889
109ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08345954
110SOX2_21211035_ChIP-Seq_LN229_Gbm1.07627913
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06255130
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06081574
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.05940217
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05802076
115EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05702952
116RING1B_27294783_Chip-Seq_ESCs_Mouse1.05505265
117PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05301999
118GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05290929
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.04679965
120CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04582984
121CREB1_26743006_Chip-Seq_LNCaP_Human1.04154675
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.04132421
123RXR_22108803_ChIP-Seq_LS180_Human1.03520263
124PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02494264
125MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02167917
126ATF3_27146783_Chip-Seq_COLON_Human1.01783896
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01455739
128TP53_16413492_ChIP-PET_HCT116_Human1.01036693
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01002064
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.00188823
131AR_19668381_ChIP-Seq_PC3_Human1.00109993
132TRIM28_21343339_ChIP-Seq_HEK293_Human0.99284650
133AR_25329375_ChIP-Seq_VCAP_Human0.99100697
134SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99084502
135KDM2B_26808549_Chip-Seq_JURKAT_Human0.98974395
136CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.98429031
137BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98388619
138SPI1_23127762_ChIP-Seq_K562_Human0.98328801
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96802522
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96518530
141* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94749233
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.94288526
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.92853955
144CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92730898
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.91864785
146ZNF274_21170338_ChIP-Seq_K562_Hela0.91398127
147IRF8_27001747_Chip-Seq_BMDM_Mouse0.90695046
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.90245610
149P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88809426
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86790617
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.85574781
152SMAD3_21741376_ChIP-Seq_ESCs_Human0.84403485
153TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84258671
154KDM2B_26808549_Chip-Seq_DND41_Human0.83855035
155SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.83253649
156SMAD3_21741376_ChIP-Seq_EPCs_Human0.83227879
157STAT3_23295773_ChIP-Seq_U87_Human0.82748976
158CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82054361
159TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81545902
160PRDM14_20953172_ChIP-Seq_ESCs_Human0.81366419
161RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81317387
162PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.80108290
163OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79493360
164RING1B_27294783_Chip-Seq_NPCs_Mouse0.78893863
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78863882
166SMC4_20622854_ChIP-Seq_HELA_Human0.77700104
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77078393
168* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.76962975
169* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.76962975
170SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76523256
171IRF8_21731497_ChIP-ChIP_J774_Mouse0.76309337
172KLF4_19829295_ChIP-Seq_ESCs_Human0.76253588
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.76244753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.22184201
2MP0003635_abnormal_synaptic_transmissio3.65052895
3MP0003880_abnormal_central_pattern3.59335511
4MP0004270_analgesia3.17396672
5MP0002139_abnormal_hepatobiliary_system3.14460392
6MP0002064_seizures3.05411688
7MP0005058_abnormal_lysosome_morphology3.00950965
8MP0009745_abnormal_behavioral_response2.81789063
9MP0002063_abnormal_learning/memory/cond2.79126961
10MP0003172_abnormal_lysosome_physiology2.74726533
11MP0009046_muscle_twitch2.62212012
12MP0001968_abnormal_touch/_nociception2.60734475
13MP0004858_abnormal_nervous_system2.50128942
14MP0003690_abnormal_glial_cell2.50082001
15MP0002822_catalepsy2.45557529
16MP0003329_amyloid_beta_deposits2.37334193
17MP0002572_abnormal_emotion/affect_behav2.29264409
18MP0003075_altered_response_to2.23099863
19MP0002736_abnormal_nociception_after2.19511948
20MP0002909_abnormal_adrenal_gland2.16249228
21MP0003436_decreased_susceptibility_to2.16124256
22MP0002734_abnormal_mechanical_nocicepti2.14443121
23MP0001486_abnormal_startle_reflex2.13717078
24MP0000343_altered_response_to2.13295532
25MP0005451_abnormal_body_composition2.12885266
26MP0000604_amyloidosis2.12602781
27MP0002272_abnormal_nervous_system2.12352996
28MP0001501_abnormal_sleep_pattern2.10232161
29MP0009780_abnormal_chondrocyte_physiolo2.09803474
30MP0003705_abnormal_hypodermis_morpholog2.07469998
31MP0002148_abnormal_hypersensitivity_rea2.02605880
32MP0008260_abnormal_autophagy1.94484933
33MP0005423_abnormal_somatic_nervous1.93275305
34MP0003453_abnormal_keratinocyte_physiol1.93141082
35MP0001970_abnormal_pain_threshold1.87757749
36MP0002733_abnormal_thermal_nociception1.86379782
37MP0009278_abnormal_bone_marrow1.83979588
38MP0003633_abnormal_nervous_system1.79802808
39MP0001440_abnormal_grooming_behavior1.76709300
40MP0008569_lethality_at_weaning1.73410355
41MP0003183_abnormal_peptide_metabolism1.71211680
42MP0005257_abnormal_intraocular_pressure1.69978890
43MP0002735_abnormal_chemical_nociception1.65251860
44MP0002067_abnormal_sensory_capabilities1.58140726
45MP0000920_abnormal_myelination1.55924095
46MP0002090_abnormal_vision1.54921277
47MP0010386_abnormal_urinary_bladder1.52734934
48MP0010234_abnormal_vibrissa_follicle1.52238836
49MP0000858_altered_metastatic_potential1.50495222
50MP0003191_abnormal_cellular_cholesterol1.48891946
51MP0004811_abnormal_neuron_physiology1.48243805
52MP0001533_abnormal_skeleton_physiology1.47611550
53MP0002877_abnormal_melanocyte_morpholog1.46186005
54MP0005310_abnormal_salivary_gland1.45791002
55MP0003634_abnormal_glial_cell1.45219212
56MP0002557_abnormal_social/conspecific_i1.41612397
57MP0004510_myositis1.39914291
58MP0003631_nervous_system_phenotype1.37447949
59MP0001849_ear_inflammation1.37087844
60MP0005167_abnormal_blood-brain_barrier1.36096532
61MP0004885_abnormal_endolymph1.35975833
62MP0004947_skin_inflammation1.34229636
63MP0005025_abnormal_response_to1.33712035
64MP0001853_heart_inflammation1.33364374
65MP0005166_decreased_susceptibility_to1.33333109
66MP0003303_peritoneal_inflammation1.32033556
67MP0005365_abnormal_bile_salt1.30139921
68MP0008438_abnormal_cutaneous_collagen1.26430385
69MP0008004_abnormal_stomach_pH1.26066279
70MP0003448_altered_tumor_morphology1.25937434
71MP0003879_abnormal_hair_cell1.25920018
72MP0004924_abnormal_behavior1.25191617
73MP0005386_behavior/neurological_phenoty1.25191617
74MP0003300_gastrointestinal_ulcer1.24396358
75MP0000955_abnormal_spinal_cord1.24271831
76MP0003279_aneurysm1.20800028
77MP0002066_abnormal_motor_capabilities/c1.20580696
78MP0002184_abnormal_innervation1.19128604
79MP0005000_abnormal_immune_tolerance1.18551428
80MP0009840_abnormal_foam_cell1.16597189
81MP0003123_paternal_imprinting1.16110290
82MP0006082_CNS_inflammation1.15975403
83MP0004130_abnormal_muscle_cell1.15293726
84MP0000569_abnormal_digit_pigmentation1.13649851
85MP0002229_neurodegeneration1.13154061
86MP0009785_altered_susceptibility_to1.12490336
87MP0001545_abnormal_hematopoietic_system1.12289313
88MP0005397_hematopoietic_system_phenotyp1.12289313
89MP0009764_decreased_sensitivity_to1.11865908
90MP0002882_abnormal_neuron_morphology1.11379366
91MP0008874_decreased_physiological_sensi1.09316576
92MP0005076_abnormal_cell_differentiation1.07863180
93MP0005646_abnormal_pituitary_gland1.07078853
94MP0003091_abnormal_cell_migration1.05434856
95MP0005535_abnormal_body_temperature1.05199995
96MP0008469_abnormal_protein_level1.04911555
97MP0003566_abnormal_cell_adhesion1.03854395
98MP0002089_abnormal_postnatal_growth/wei1.03606808
99MP0001542_abnormal_bone_strength1.02808027
100MP0000685_abnormal_immune_system1.02208201
101MP0008961_abnormal_basal_metabolism0.99019992
102MP0001845_abnormal_inflammatory_respons0.97611280
103MP0000013_abnormal_adipose_tissue0.97181743
104MP0003632_abnormal_nervous_system0.96534249
105MP0000778_abnormal_nervous_system0.95949037
106MP0001502_abnormal_circadian_rhythm0.95430314
107MP0003806_abnormal_nucleotide_metabolis0.93144092
108MP0006054_spinal_hemorrhage0.91500641
109MP0000681_abnormal_thyroid_gland0.91011727
110MP0005023_abnormal_wound_healing0.89075136
111MP0004142_abnormal_muscle_tone0.88032768
112MP0002896_abnormal_bone_mineralization0.87383510
113MP0001790_abnormal_immune_system0.85958794
114MP0005387_immune_system_phenotype0.85958794
115MP0001905_abnormal_dopamine_level0.85810603
116MP0001984_abnormal_olfaction0.84448581
117MP0002452_abnormal_antigen_presenting0.84310346
118MP0005666_abnormal_adipose_tissue0.83188711
119MP0005595_abnormal_vascular_smooth0.82063989
120MP0002069_abnormal_eating/drinking_beha0.79917222
121MP0003045_fibrosis0.79202411
122MP0001765_abnormal_ion_homeostasis0.77959796
123MP0000751_myopathy0.77400904
124MP0010155_abnormal_intestine_physiology0.75677696
125MP0004019_abnormal_vitamin_homeostasis0.75665665
126MP0001177_atelectasis0.75084827
127MP0005390_skeleton_phenotype0.74016344
128MP0000747_muscle_weakness0.73414358
129MP0003795_abnormal_bone_structure0.73350005
130MP0002723_abnormal_immune_serum0.73196043
131MP0002152_abnormal_brain_morphology0.72840623
132MP0006276_abnormal_autonomic_nervous0.71705396
133MP0005375_adipose_tissue_phenotype0.71187123
134MP0004043_abnormal_pH_regulation0.69841679
135MP0008872_abnormal_physiological_respon0.69625124
136MP0001299_abnormal_eye_distance/0.69195827
137MP0004145_abnormal_muscle_electrophysio0.68435823
138MP0001664_abnormal_digestion0.66681180
139MP0005645_abnormal_hypothalamus_physiol0.64998178
140MP0004233_abnormal_muscle_weight0.63914660
141MP0005671_abnormal_response_to0.63459139
142MP0002118_abnormal_lipid_homeostasis0.62635522
143MP0009333_abnormal_splenocyte_physiolog0.62405274
144MP0004185_abnormal_adipocyte_glucose0.61299657
145MP0004484_altered_response_of0.59937089
146MP0001835_abnormal_antigen_presentation0.59194823
147MP0004085_abnormal_heartbeat0.57481487
148MP0003724_increased_susceptibility_to0.56876684
149MP0003283_abnormal_digestive_organ0.56593500
150MP0004742_abnormal_vestibular_system0.56164585
151MP0002796_impaired_skin_barrier0.55972389
152MP0001819_abnormal_immune_cell0.55375341
153MP0001963_abnormal_hearing_physiology0.54993627
154MP0002420_abnormal_adaptive_immunity0.53983881
155MP0002998_abnormal_bone_remodeling0.49420248
156MP0005464_abnormal_platelet_physiology0.47700873
157MP0005584_abnormal_enzyme/coenzyme_acti0.47678737
158MP0002254_reproductive_system_inflammat0.45407235
159MP0005165_increased_susceptibility_to0.45236196
160MP0000230_abnormal_systemic_arterial0.44228172
161MP0002419_abnormal_innate_immunity0.43442290

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.66446826
2Focal motor seizures (HP:0011153)5.16851069
3Supranuclear gaze palsy (HP:0000605)4.60589806
4Mutism (HP:0002300)4.21870309
5Focal seizures (HP:0007359)4.21438708
6Increased cerebral lipofuscin (HP:0011813)4.13336083
7Abnormality of glycolipid metabolism (HP:0010969)4.08272580
8Abnormality of liposaccharide metabolism (HP:0010968)4.08272580
9Abnormality of glycosphingolipid metabolism (HP:0004343)4.08272580
10Nuclear cataract (HP:0100018)4.01362364
11Visual hallucinations (HP:0002367)3.97466378
12Action tremor (HP:0002345)3.94831058
13Neurofibrillary tangles (HP:0002185)3.93748942
14Dysostosis multiplex (HP:0000943)3.85098117
15Cerebral inclusion bodies (HP:0100314)3.52322445
16Systemic lupus erythematosus (HP:0002725)3.43389045
17Neuronal loss in central nervous system (HP:0002529)3.34542217
18Vertebral compression fractures (HP:0002953)3.27486054
19Increased neuronal autofluorescent lipopigment (HP:0002074)3.26978617
20Atonic seizures (HP:0010819)3.23898071
21Postural instability (HP:0002172)3.19951251
22Ankle clonus (HP:0011448)3.12678734
23Papilledema (HP:0001085)3.08706526
24Abnormality of macrophages (HP:0004311)3.07546822
25Urinary glycosaminoglycan excretion (HP:0003541)3.04316593
26Mucopolysacchariduria (HP:0008155)3.04316593
27Depression (HP:0000716)3.00725365
28Abnormality of polysaccharide metabolism (HP:0011012)2.97724936
29Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97724936
30Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97724936
31Generalized tonic-clonic seizures (HP:0002069)2.97380711
32Epileptic encephalopathy (HP:0200134)2.96510841
33Upper motor neuron abnormality (HP:0002127)2.94873260
34Absence seizures (HP:0002121)2.88753525
35Retinal atrophy (HP:0001105)2.81196144
36Dialeptic seizures (HP:0011146)2.76448506
37Arterial tortuosity (HP:0005116)2.75355678
38Hemiplegia (HP:0002301)2.74502984
39Abnormal eating behavior (HP:0100738)2.73263713
40Apathy (HP:0000741)2.71382298
41Progressive cerebellar ataxia (HP:0002073)2.67631847
42Prolonged neonatal jaundice (HP:0006579)2.63210651
43Progressive neurologic deterioration (HP:0002344)2.61568025
44Axonal loss (HP:0003447)2.60362900
45Febrile seizures (HP:0002373)2.55189877
46Diminished motivation (HP:0000745)2.54896419
47Truncal ataxia (HP:0002078)2.54719886
48Glomerulonephritis (HP:0000099)2.53680290
49Vacuolated lymphocytes (HP:0001922)2.52523781
50Impaired vibration sensation in the lower limbs (HP:0002166)2.52418840
51Urinary urgency (HP:0000012)2.47069371
52Purpura (HP:0000979)2.46858604
53Urinary bladder sphincter dysfunction (HP:0002839)2.46680472
54* Dysmetria (HP:0001310)2.43937809
55Loss of speech (HP:0002371)2.43456391
56Dysdiadochokinesis (HP:0002075)2.40494371
57Abnormality of binocular vision (HP:0011514)2.39237502
58Diplopia (HP:0000651)2.39237502
59Status epilepticus (HP:0002133)2.38634501
60Vascular tortuosity (HP:0004948)2.38333286
61Personality changes (HP:0000751)2.36540509
62Rapidly progressive (HP:0003678)2.36395992
63Termporal pattern (HP:0011008)2.34689096
64Insidious onset (HP:0003587)2.34689096
65Anxiety (HP:0000739)2.34383909
66Amyloidosis (HP:0011034)2.33450963
67Torticollis (HP:0000473)2.32709666
68Pathologic fracture (HP:0002756)2.32182313
69Impaired social interactions (HP:0000735)2.30942603
70Abnormal social behavior (HP:0012433)2.30942603
71Poor eye contact (HP:0000817)2.29796268
72Disinhibition (HP:0000734)2.29046927
73Cerebral aneurysm (HP:0004944)2.28213425
74* Intention tremor (HP:0002080)2.28078219
75Dementia (HP:0000726)2.28056557
76Myocardial infarction (HP:0001658)2.27611731
77Abnormality of complement system (HP:0005339)2.25338647
78Abnormality of the periventricular white matter (HP:0002518)2.24593585
79Global brain atrophy (HP:0002283)2.24399051
80Megalencephaly (HP:0001355)2.23690786
81Inappropriate behavior (HP:0000719)2.22461739
82Hyperparathyroidism (HP:0000843)2.21819078
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.20080695
84Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19184891
85Stereotypic behavior (HP:0000733)2.17760518
86Spastic gait (HP:0002064)2.17626992
87Hyperacusis (HP:0010780)2.16123856
88Complement deficiency (HP:0004431)2.15580968
89Bradykinesia (HP:0002067)2.15454383
90Rigidity (HP:0002063)2.15396984
91Bone pain (HP:0002653)2.10988271
92Lower limb asymmetry (HP:0100559)2.09736852
93Asymmetric septal hypertrophy (HP:0001670)2.09523519
94Ventricular fibrillation (HP:0001663)2.09505425
95Agnosia (HP:0010524)2.08823151
96Thoracic kyphosis (HP:0002942)2.07502254
97Progressive inability to walk (HP:0002505)2.05764300
98Recurrent abscess formation (HP:0002722)2.05558902
99Annular pancreas (HP:0001734)2.05139856
100Focal dystonia (HP:0004373)2.05085199
101Upper limb amyotrophy (HP:0009129)2.04708252
102Distal upper limb amyotrophy (HP:0007149)2.04708252
103Clumsiness (HP:0002312)2.04398528
104Cardiomegaly (HP:0001640)2.03132874
105Abnormality of the lower motor neuron (HP:0002366)2.01572122
106Gaze-evoked nystagmus (HP:0000640)2.00960027
107Aplasia involving bones of the extremities (HP:0009825)1.97469735
108Aplasia involving bones of the upper limbs (HP:0009823)1.97469735
109Aplasia of the phalanges of the hand (HP:0009802)1.97469735
110Eczematoid dermatitis (HP:0000976)1.96627192
111J-shaped sella turcica (HP:0002680)1.95970900
112Increased CSF protein (HP:0002922)1.95783601
113Recurrent gram-negative bacterial infections (HP:0005420)1.95474504
114Lower limb muscle weakness (HP:0007340)1.94859978
115Hemiparesis (HP:0001269)1.94535831
116Hepatosplenomegaly (HP:0001433)1.94220371
117Urinary incontinence (HP:0000020)1.93639266
118Increased serum ferritin (HP:0003281)1.93301373
119Hand muscle atrophy (HP:0009130)1.92828609
120Peripheral demyelination (HP:0011096)1.91964066
121Impaired smooth pursuit (HP:0007772)1.91710969
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.91417149
123Striae distensae (HP:0001065)1.90915786
124Premature rupture of membranes (HP:0001788)1.90857527
125Xanthomatosis (HP:0000991)1.89599883
126Pheochromocytoma (HP:0002666)1.89522383
127Agitation (HP:0000713)1.89409076
128Craniofacial dystonia (HP:0012179)1.87806284
129Amblyopia (HP:0000646)1.85576344
130Psychosis (HP:0000709)1.83792276
131Abnormality of the thoracic spine (HP:0100711)1.80317703
132Recurrent bacterial skin infections (HP:0005406)1.74862564
133Insomnia (HP:0100785)1.74146772
134Joint stiffness (HP:0001387)1.73477173
135Thin bony cortex (HP:0002753)1.72704154
136Zonular cataract (HP:0010920)1.69421137
137Deep venous thrombosis (HP:0002625)1.68822523
138Cervical subluxation (HP:0003308)1.68148898
139Mediastinal lymphadenopathy (HP:0100721)1.66749916
140Multiple enchondromatosis (HP:0005701)1.66740623
141Autoimmune thrombocytopenia (HP:0001973)1.66461623
142Distal lower limb muscle weakness (HP:0009053)1.66173530
143Metaphyseal irregularity (HP:0003025)1.65062616
144Distal lower limb amyotrophy (HP:0008944)1.63100976
145Protrusio acetabuli (HP:0003179)1.60792104
146Polygenic inheritance (HP:0010982)1.59712113
147Malnutrition (HP:0004395)1.57104847
148Tetraparesis (HP:0002273)1.57024087
149Interstitial pulmonary disease (HP:0006530)1.56031059
150Multiple lipomas (HP:0001012)1.55293352
151Ovoid vertebral bodies (HP:0003300)1.55095173
152Abnormality of the lumbar spine (HP:0100712)1.54691326
153Paraparesis (HP:0002385)1.52442215
154Hemorrhage of the eye (HP:0011885)1.52165841
155Short nail (HP:0001799)1.48604846
156Abnormal neuron morphology (HP:0012757)1.47695920
157Abnormality of the motor neurons (HP:0002450)1.47695920
158Hypophosphatemia (HP:0002148)1.47363962
159Nephritis (HP:0000123)1.46528670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.08242881
2IRAK34.04588128
3NME24.02386070
4EPHA43.82601527
5NTRK33.49056565
6TESK13.08760179
7KSR23.00031484
8RIPK42.97520159
9MAP3K112.70811456
10TAOK22.46620051
11CAMKK12.43640306
12DAPK22.37388620
13MINK12.31867348
14PRKD32.28366316
15TESK22.15633440
16PAK62.14523939
17NTRK12.11695909
18PIM22.09111385
19ARAF2.04831166
20MAP3K41.99563656
21MAP3K131.91017946
22ICK1.88564844
23MAP3K21.85882759
24CAMKK21.83443755
25SIK11.82984397
26LMTK21.76216014
27LIMK11.75078621
28ABL21.65764522
29TBK11.60778991
30FES1.50845483
31MAP2K41.42172384
32MAP3K31.40835253
33CDK51.40319766
34NTRK21.39509126
35TRIB31.39168523
36SCYL21.34884112
37GRK51.34736389
38TGFBR21.29727096
39CDC42BPA1.27667307
40MARK11.27377401
41KSR11.26646373
42STK381.25519431
43PAK41.24920329
44LATS21.21506908
45EPHA21.20587235
46MAP2K71.18373637
47CAMK1G1.17583192
48MATK1.17463549
49MAP3K121.17264995
50DAPK11.16830291
51RIPK11.16401345
52SMG11.15215276
53TYRO31.10887687
54RET1.07720602
55PDPK11.07272959
56PDK11.07180182
57STK391.01648675
58OXSR11.00859922
59MAP3K141.00191758
60PRKCH0.99950660
61TAOK10.99401605
62CDK190.95811175
63BLK0.92460302
64ERN10.90697227
65CAMK1D0.89983152
66MAP2K30.89430486
67RAF10.88713160
68SIK20.88030619
69FGR0.87732814
70PHKG20.85525384
71PHKG10.85525384
72MAP3K10.82977457
73PRKCG0.82797477
74PLK20.81965861
75IRAK20.80722333
76CAMK10.80568752
77PTK2B0.80166515
78TNK20.77689307
79EPHB20.76234335
80BRAF0.75465921
81TYK20.74246210
82PRPF4B0.73907148
83PTK20.73866120
84PRKG20.73851323
85MAPKAPK50.72583275
86MARK20.72050999
87MOS0.71990104
88SGK2230.71134064
89SGK4940.71134064
90UHMK10.70183589
91STK110.69856259
92DMPK0.69434520
93TTN0.67966682
94CDK150.67647530
95WNK10.67587200
96CAMK2A0.67353845
97GRK70.66883933
98CDK180.66848924
99PINK10.66564622
100CSF1R0.65906567
101CDK140.64824714
102SGK30.64365758
103FYN0.60697408
104PRKD20.58721956
105CAMK2B0.58232038
106JAK10.55646308
107FGFR40.55378102
108CDK11A0.54545275
109RPS6KL10.54072107
110RPS6KC10.54072107
111MAPK120.53896389
112MAP2K10.53749945
113MST1R0.53609386
114PDK20.53302768
115JAK20.52123662
116BCKDK0.51758823
117IKBKB0.49745021
118DAPK30.49388302
119MAPK130.48983714
120CAMK2G0.48773619
121ALK0.48696775
122PKN20.46152912
123PAK30.45427799
124PRKCZ0.44459450
125RPS6KA20.44112554
126CSK0.43009912
127SGK10.42859019
128IRAK40.42272859
129MAP2K60.42094644
130BMX0.40757970
131MAPK40.38370394
132FRK0.38238631
133PDGFRA0.38003715
134CDK60.37749488
135CAMK40.37695024
136FER0.37498024
137DDR20.36586352
138MAPKAPK30.36585954
139SGK20.36426202
140HCK0.36225186
141CAMK2D0.36193208
142BMPR20.36148051
143MAP3K70.35535860
144DYRK1B0.35252513
145MTOR0.34719150
146SIK30.33431062
147PAK10.33117926
148PBK0.31792021
149ROCK20.31748471
150RPS6KA60.31738267
151SRC0.31392011

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.90460072
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.35467087
3Olfactory transduction_Homo sapiens_hsa047402.25079355
4Nicotine addiction_Homo sapiens_hsa050332.24237334
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.18360517
6Nitrogen metabolism_Homo sapiens_hsa009102.09361751
7Long-term potentiation_Homo sapiens_hsa047202.06377921
8GABAergic synapse_Homo sapiens_hsa047271.97694921
9Circadian entrainment_Homo sapiens_hsa047131.96943620
10Glutamatergic synapse_Homo sapiens_hsa047241.91047376
11Salivary secretion_Homo sapiens_hsa049701.89923235
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88772547
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.82528341
14Morphine addiction_Homo sapiens_hsa050321.81606812
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.76946359
16Amphetamine addiction_Homo sapiens_hsa050311.75021709
17Gastric acid secretion_Homo sapiens_hsa049711.73040184
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.71492860
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70344840
20Lysosome_Homo sapiens_hsa041421.65510165
21Dopaminergic synapse_Homo sapiens_hsa047281.59538245
22Collecting duct acid secretion_Homo sapiens_hsa049661.54545306
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52777354
24Cholinergic synapse_Homo sapiens_hsa047251.52295815
25Insulin secretion_Homo sapiens_hsa049111.51087581
26Galactose metabolism_Homo sapiens_hsa000521.47806204
27Renin secretion_Homo sapiens_hsa049241.46076299
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44411733
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.44243487
30Leishmaniasis_Homo sapiens_hsa051401.37554801
31Bladder cancer_Homo sapiens_hsa052191.36285480
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35101192
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34097684
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.33563747
35Oxytocin signaling pathway_Homo sapiens_hsa049211.33498365
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29702391
37GnRH signaling pathway_Homo sapiens_hsa049121.29277404
38Cocaine addiction_Homo sapiens_hsa050301.27430113
39Long-term depression_Homo sapiens_hsa047301.26654143
40Vitamin B6 metabolism_Homo sapiens_hsa007501.25084469
41Sphingolipid metabolism_Homo sapiens_hsa006001.21650593
42Fructose and mannose metabolism_Homo sapiens_hsa000511.21348760
43Other glycan degradation_Homo sapiens_hsa005111.20150029
44Vibrio cholerae infection_Homo sapiens_hsa051101.17725757
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17195353
46Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15228052
47Calcium signaling pathway_Homo sapiens_hsa040201.14936701
48Prion diseases_Homo sapiens_hsa050201.14741805
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14125320
50Glioma_Homo sapiens_hsa052141.12768508
51Estrogen signaling pathway_Homo sapiens_hsa049151.11699074
52Gap junction_Homo sapiens_hsa045401.07849211
53TNF signaling pathway_Homo sapiens_hsa046681.07045846
54Serotonergic synapse_Homo sapiens_hsa047261.06707026
55cAMP signaling pathway_Homo sapiens_hsa040241.06015664
56Type II diabetes mellitus_Homo sapiens_hsa049301.05654177
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02101679
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97892488
59Amoebiasis_Homo sapiens_hsa051460.97008677
60Shigellosis_Homo sapiens_hsa051310.95860223
61Taste transduction_Homo sapiens_hsa047420.95481666
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.94509540
63Malaria_Homo sapiens_hsa051440.94486800
64Complement and coagulation cascades_Homo sapiens_hsa046100.93933324
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90715037
66Endocytosis_Homo sapiens_hsa041440.89987970
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.88834207
68Pentose phosphate pathway_Homo sapiens_hsa000300.88685833
69Toxoplasmosis_Homo sapiens_hsa051450.85056771
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85047983
71ErbB signaling pathway_Homo sapiens_hsa040120.84779909
72Pancreatic secretion_Homo sapiens_hsa049720.83443728
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83106479
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.82052764
75VEGF signaling pathway_Homo sapiens_hsa043700.81913843
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.81023621
77Dorso-ventral axis formation_Homo sapiens_hsa043200.79593767
78Thyroid hormone synthesis_Homo sapiens_hsa049180.79381150
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.78308183
80Legionellosis_Homo sapiens_hsa051340.76877658
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.76573536
82Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76562695
83Hepatitis C_Homo sapiens_hsa051600.75325423
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73631922
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.71578003
86Choline metabolism in cancer_Homo sapiens_hsa052310.71082135
87PPAR signaling pathway_Homo sapiens_hsa033200.70442112
88Acute myeloid leukemia_Homo sapiens_hsa052210.70204218
89Osteoclast differentiation_Homo sapiens_hsa043800.70157875
90Tuberculosis_Homo sapiens_hsa051520.66389960
91Phagosome_Homo sapiens_hsa041450.65440264
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65334760
93Staphylococcus aureus infection_Homo sapiens_hsa051500.65244407
94Melanogenesis_Homo sapiens_hsa049160.63164984
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62793844
96Inositol phosphate metabolism_Homo sapiens_hsa005620.62515599
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.62385807
98Renin-angiotensin system_Homo sapiens_hsa046140.62280812
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61559937
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.59654501
101Apoptosis_Homo sapiens_hsa042100.59250304
102Chemokine signaling pathway_Homo sapiens_hsa040620.59244949
103Bile secretion_Homo sapiens_hsa049760.59234412
104Asthma_Homo sapiens_hsa053100.58583767
105Renal cell carcinoma_Homo sapiens_hsa052110.57637051
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.56802813
107Antigen processing and presentation_Homo sapiens_hsa046120.56685954
108Rap1 signaling pathway_Homo sapiens_hsa040150.56642503
109B cell receptor signaling pathway_Homo sapiens_hsa046620.56558972
110mTOR signaling pathway_Homo sapiens_hsa041500.55837568
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.55796560
112Non-small cell lung cancer_Homo sapiens_hsa052230.55532736
113Axon guidance_Homo sapiens_hsa043600.55417457
114Glutathione metabolism_Homo sapiens_hsa004800.54882880
115MAPK signaling pathway_Homo sapiens_hsa040100.54782629
116Sulfur relay system_Homo sapiens_hsa041220.54596443
117Rheumatoid arthritis_Homo sapiens_hsa053230.53868847
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53575339
119Dilated cardiomyopathy_Homo sapiens_hsa054140.52596617
120Chronic myeloid leukemia_Homo sapiens_hsa052200.51865118
121Salmonella infection_Homo sapiens_hsa051320.51652229
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51069505
123Allograft rejection_Homo sapiens_hsa053300.51068841
124Influenza A_Homo sapiens_hsa051640.50841170
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50279581
126Notch signaling pathway_Homo sapiens_hsa043300.49993862
127Ras signaling pathway_Homo sapiens_hsa040140.48969336
128Pertussis_Homo sapiens_hsa051330.47908709
129Mineral absorption_Homo sapiens_hsa049780.47341500
130N-Glycan biosynthesis_Homo sapiens_hsa005100.46593005
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45145803
132Platelet activation_Homo sapiens_hsa046110.44976246
133Sulfur metabolism_Homo sapiens_hsa009200.44492576
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.43641334
135African trypanosomiasis_Homo sapiens_hsa051430.43452782
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43011018
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42904948
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.41540592
139Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40588518
140Hepatitis B_Homo sapiens_hsa051610.40507251
141NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40119742
142Endometrial cancer_Homo sapiens_hsa052130.40094580
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40032146
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38462453
145HIF-1 signaling pathway_Homo sapiens_hsa040660.38186248
146Cardiac muscle contraction_Homo sapiens_hsa042600.38039506
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37798541
148Insulin signaling pathway_Homo sapiens_hsa049100.37416899
149Viral myocarditis_Homo sapiens_hsa054160.37412410
150Carbon metabolism_Homo sapiens_hsa012000.37364847
151Pancreatic cancer_Homo sapiens_hsa052120.36654016
152Biosynthesis of amino acids_Homo sapiens_hsa012300.35847405
153Proteoglycans in cancer_Homo sapiens_hsa052050.34093741
154Prolactin signaling pathway_Homo sapiens_hsa049170.33241755
155Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31066573
156Phenylalanine metabolism_Homo sapiens_hsa003600.30458407

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