ABHD12B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)7.40956080
2regulation of gene silencing by RNA (GO:0060966)7.01240294
3regulation of posttranscriptional gene silencing (GO:0060147)7.01240294
4regulation of gene silencing by miRNA (GO:0060964)7.01240294
5regulation of water loss via skin (GO:0033561)6.22687966
6keratinization (GO:0031424)5.50721740
7desmosome organization (GO:0002934)5.44967178
8sphingoid metabolic process (GO:0046519)5.20031024
9establishment of integrated proviral latency (GO:0075713)5.19897414
10detection of bacterium (GO:0016045)5.12546583
11pre-miRNA processing (GO:0031054)4.84428427
12detection of other organism (GO:0098543)4.69053353
13L-serine metabolic process (GO:0006563)4.42779752
14chromatin remodeling at centromere (GO:0031055)4.37633596
15positive regulation of SMAD protein import into nucleus (GO:0060391)4.34291974
16protein localization to kinetochore (GO:0034501)4.27832889
17CENP-A containing nucleosome assembly (GO:0034080)4.21459165
18regulation of helicase activity (GO:0051095)4.20677736
19IMP biosynthetic process (GO:0006188)4.10067508
20regulation of mitotic spindle checkpoint (GO:1903504)4.09871348
21regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.09871348
22superoxide anion generation (GO:0042554)4.04001506
23negative regulation of translation, ncRNA-mediated (GO:0040033)4.03585387
24regulation of translation, ncRNA-mediated (GO:0045974)4.03585387
25negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.03585387
26histone exchange (GO:0043486)4.01755699
27DNA replication checkpoint (GO:0000076)4.00914085
28negative regulation of DNA-dependent DNA replication (GO:2000104)3.96986424
29multicellular organismal water homeostasis (GO:0050891)3.94771511
30keratinocyte development (GO:0003334)3.91696519
31DNA replication-dependent nucleosome assembly (GO:0006335)3.88847855
32DNA replication-dependent nucleosome organization (GO:0034723)3.88847855
33heterochromatin organization (GO:0070828)3.84279372
34regulation of gene silencing (GO:0060968)3.82689264
35establishment of viral latency (GO:0019043)3.82102574
36regulation of histone H3-K9 methylation (GO:0051570)3.81206143
37negative regulation of gene silencing (GO:0060969)3.80634818
38protein complex localization (GO:0031503)3.79717255
39cell fate commitment involved in formation of primary germ layer (GO:0060795)3.76187815
40IMP metabolic process (GO:0046040)3.74334859
41somatic diversification of immune receptors via somatic mutation (GO:0002566)3.71690654
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.71690654
43DNA replication-independent nucleosome assembly (GO:0006336)3.69400133
44DNA replication-independent nucleosome organization (GO:0034724)3.69400133
45negative regulation of mitotic sister chromatid separation (GO:2000816)3.62296973
46negative regulation of sister chromatid segregation (GO:0033046)3.62296973
47negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.62296973
48negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.62296973
49negative regulation of mitotic sister chromatid segregation (GO:0033048)3.62296973
50positive regulation of cellular amide metabolic process (GO:0034250)3.62011051
51mitotic metaphase plate congression (GO:0007080)3.58138825
52negative regulation of chromosome segregation (GO:0051985)3.57343722
53regulation of chromatin silencing (GO:0031935)3.54996798
54ribosome assembly (GO:0042255)3.51713011
55DNA strand elongation involved in DNA replication (GO:0006271)3.50272151
56regulation of cell fate specification (GO:0042659)3.49762767
57purine nucleobase biosynthetic process (GO:0009113)3.48188722
58nucleobase biosynthetic process (GO:0046112)3.46453111
59sphingosine metabolic process (GO:0006670)3.44551768
60diol metabolic process (GO:0034311)3.40618265
61anterior/posterior axis specification, embryo (GO:0008595)3.37830194
62mitotic spindle checkpoint (GO:0071174)3.36286901
63nodal signaling pathway (GO:0038092)3.36053127
64spindle checkpoint (GO:0031577)3.34384122
65lysine catabolic process (GO:0006554)3.32438550
66lysine metabolic process (GO:0006553)3.32438550
67L-alpha-amino acid transmembrane transport (GO:1902475)3.32253321
68DNA damage response, detection of DNA damage (GO:0042769)3.31834253
69telomere maintenance via telomerase (GO:0007004)3.31517648
70DNA strand elongation (GO:0022616)3.29470340
71molting cycle (GO:0042303)3.29097293
72hair cycle (GO:0042633)3.29097293
73nuclear pore complex assembly (GO:0051292)3.22180205
74intermediate filament organization (GO:0045109)3.22033952
75negative regulation of telomerase activity (GO:0051974)3.21956053
76protein localization to chromosome, centromeric region (GO:0071459)3.21896795
77keratinocyte differentiation (GO:0030216)3.21617809
78water homeostasis (GO:0030104)3.20571140
79regulation of DNA methylation (GO:0044030)3.17663959
80regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14036292
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.14036292
82mitotic spindle assembly checkpoint (GO:0007094)3.13360677
83ceramide catabolic process (GO:0046514)3.12095147
84regulation of sister chromatid segregation (GO:0033045)3.11735969
85regulation of mitotic sister chromatid separation (GO:0010965)3.11735969
86regulation of mitotic sister chromatid segregation (GO:0033047)3.11735969
87lung-associated mesenchyme development (GO:0060484)3.10215311
88regulation of centriole replication (GO:0046599)3.09927431
89positive regulation of interleukin-1 beta secretion (GO:0050718)3.08582510
90single strand break repair (GO:0000012)3.08505390
91regulation of cell fate commitment (GO:0010453)3.07849596
92nuclear pore organization (GO:0006999)3.07797453
93proteasome assembly (GO:0043248)3.05110462
94spindle assembly checkpoint (GO:0071173)3.04842406
95regulation of telomere maintenance via telomerase (GO:0032210)3.03829153
96regulation of nuclear cell cycle DNA replication (GO:0033262)3.03221269
97regulation of chromosome segregation (GO:0051983)3.01192470
98response to X-ray (GO:0010165)3.00655075
99glycosphingolipid catabolic process (GO:0046479)2.99136212
100cyclooxygenase pathway (GO:0019371)2.98963540
101regulation of male gonad development (GO:2000018)2.98868519
102metaphase plate congression (GO:0051310)2.97489950
103regulation of SMAD protein import into nucleus (GO:0060390)2.97238555
104regulation of meiosis I (GO:0060631)2.97043026
105DNA unwinding involved in DNA replication (GO:0006268)2.96473900
106histone arginine methylation (GO:0034969)2.96398376
107ncRNA catabolic process (GO:0034661)2.96152925
108negative regulation of mitosis (GO:0045839)2.95671944
109regulation of dendritic cell antigen processing and presentation (GO:0002604)2.95099821
110regulation of chemokine secretion (GO:0090196)2.94539492
111ATP-dependent chromatin remodeling (GO:0043044)2.93502228
112negative regulation of T cell mediated immunity (GO:0002710)2.92723282
113positive regulation of antigen processing and presentation (GO:0002579)2.92560357
114negative regulation of androgen receptor signaling pathway (GO:0060766)2.91416692
115negative regulation of histone methylation (GO:0031061)2.90193727
116lipoxygenase pathway (GO:0019372)2.89858055
117telomere maintenance via semi-conservative replication (GO:0032201)2.88229466
118female gonad development (GO:0008585)2.87886726
119mitotic G2/M transition checkpoint (GO:0044818)2.87363767
120negative regulation of DNA recombination (GO:0045910)2.87211262
121negative regulation of keratinocyte proliferation (GO:0010839)2.86715402
122adenosine metabolic process (GO:0046085)2.86560050
123positive regulation of chemokine secretion (GO:0090197)2.86504233
124serine family amino acid biosynthetic process (GO:0009070)2.86126019
125energy homeostasis (GO:0097009)2.85476960
126non-recombinational repair (GO:0000726)2.85266305
127double-strand break repair via nonhomologous end joining (GO:0006303)2.85266305
128DNA replication initiation (GO:0006270)2.83458626
129isotype switching (GO:0045190)2.82870970
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82870970
131negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81956985
132DNA catabolic process, exonucleolytic (GO:0000738)2.81711640
133negative regulation of mast cell activation (GO:0033004)2.80963642
134dendritic cell chemotaxis (GO:0002407)2.80400438
135positive regulation of interleukin-1 secretion (GO:0050716)2.80060647
136regulation of interleukin-1 beta secretion (GO:0050706)2.79478992
137neutrophil activation (GO:0042119)2.78887735
138long-chain fatty acid biosynthetic process (GO:0042759)2.78339543
139positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75881329
140regulation of cell proliferation involved in kidney development (GO:1901722)2.73966631
141polyketide metabolic process (GO:0030638)2.70364514
142doxorubicin metabolic process (GO:0044598)2.70364514
143daunorubicin metabolic process (GO:0044597)2.70364514
144regulation of interleukin-8 secretion (GO:2000482)2.70308610
145regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.69551765
146regulation of antigen processing and presentation (GO:0002577)2.68633784
147cell differentiation involved in metanephros development (GO:0072202)2.68403117
148positive regulation of male gonad development (GO:2000020)2.66529189
149G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.64868607
150regulation of phospholipase A2 activity (GO:0032429)2.63267419
151glycolipid catabolic process (GO:0019377)2.63266133
152detection of external biotic stimulus (GO:0098581)2.60757636
153DNA dealkylation (GO:0035510)2.59190834
154sphingolipid catabolic process (GO:0030149)2.58147264
155regulation of RIG-I signaling pathway (GO:0039535)2.57771506
156response to peptidoglycan (GO:0032494)2.56212931
157interferon-gamma production (GO:0032609)2.55293827
158phospholipid scrambling (GO:0017121)2.54911286
159regulation of activation of Janus kinase activity (GO:0010533)2.54868443
160positive regulation of interleukin-1 beta production (GO:0032731)2.52973692
161dendritic cell migration (GO:0036336)2.51171520
162epidermis development (GO:0008544)2.50015420
163kinetochore assembly (GO:0051382)2.48276277
164granulocyte activation (GO:0036230)2.46670968
165regulation of natural killer cell differentiation (GO:0032823)2.46416581
166DNA synthesis involved in DNA repair (GO:0000731)2.46341673
167regulation of ruffle assembly (GO:1900027)2.43367592
168CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.42606761
169T-helper cell differentiation (GO:0042093)2.42606761
170pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.41958340
171positive regulation of hair follicle development (GO:0051798)2.41839264
172positive regulation of hair cycle (GO:0042635)2.41839264
173transcription elongation from RNA polymerase III promoter (GO:0006385)2.41712775
174termination of RNA polymerase III transcription (GO:0006386)2.41712775
175DNA double-strand break processing (GO:0000729)2.41581222
176peptide cross-linking (GO:0018149)2.41210532
177deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.38654279
178positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.38523286
179positive regulation of interleukin-8 secretion (GO:2000484)2.37021739
180termination of RNA polymerase I transcription (GO:0006363)2.37009944
181positive regulation of interleukin-10 production (GO:0032733)2.36799330
182myeloid dendritic cell activation (GO:0001773)2.35556419
183epidermal cell differentiation (GO:0009913)2.33592150
184response to muramyl dipeptide (GO:0032495)2.33083419
185deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.32950024
186transcription elongation from RNA polymerase I promoter (GO:0006362)2.31832192
187regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.31581331
188DNA integration (GO:0015074)2.30379322
189negative regulation of systemic arterial blood pressure (GO:0003085)2.30369369
190kinetochore organization (GO:0051383)2.30338038
191histamine secretion (GO:0001821)2.29669919
192regulation of hypersensitivity (GO:0002883)2.28908847
193negative regulation of kidney development (GO:0090185)2.27255605
194regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.26995482
195protein heterotetramerization (GO:0051290)2.25721155
196regulation of interleukin-1 secretion (GO:0050704)2.24566439
197positive regulation of interleukin-1 production (GO:0032732)2.23885585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.32075726
2CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.62083795
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.87586179
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.56823087
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.21764468
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.07678603
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.07678603
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.07678603
9SALL1_21062744_ChIP-ChIP_HESCs_Human3.03863179
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.80587845
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.73794367
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.72547715
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.66696619
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.65095800
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.63799943
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.63227901
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51901021
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.49200584
19SUZ12_27294783_Chip-Seq_NPCs_Mouse2.48734135
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.48683031
21NFE2_27457419_Chip-Seq_LIVER_Mouse2.45857645
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37163461
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36291592
24GBX2_23144817_ChIP-Seq_PC3_Human2.31113829
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29111377
26PCGF2_27294783_Chip-Seq_NPCs_Mouse2.17623637
27SMAD_19615063_ChIP-ChIP_OVARY_Human2.17223993
28NANOG_16153702_ChIP-ChIP_HESCs_Human2.14882312
29VDR_22108803_ChIP-Seq_LS180_Human2.12992701
30NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10151645
31IRF8_21731497_ChIP-ChIP_J774_Mouse2.03163559
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.01204059
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.00464135
34EZH2_27294783_Chip-Seq_NPCs_Mouse1.98421320
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.98304292
36SOX2_16153702_ChIP-ChIP_HESCs_Human1.97647997
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92496861
38IRF8_22096565_ChIP-ChIP_GC-B_Human1.89453509
39ZNF274_21170338_ChIP-Seq_K562_Hela1.87222962
40EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.87060442
41ELK1_19687146_ChIP-ChIP_HELA_Human1.86614396
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86220764
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.85473646
44CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83900520
45STAT3_18555785_Chip-Seq_ESCs_Mouse1.82885812
46NMYC_18555785_Chip-Seq_ESCs_Mouse1.82884162
47P53_22387025_ChIP-Seq_ESCs_Mouse1.81200833
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80483453
49SUZ12_18555785_Chip-Seq_ESCs_Mouse1.79808533
50TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.79005434
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.77390834
52TCF3_18692474_ChIP-Seq_MEFs_Mouse1.75207503
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.74881130
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74707900
55NELFA_20434984_ChIP-Seq_ESCs_Mouse1.74577825
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74558264
57EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.74298003
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.73951407
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.72588561
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71198407
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67805252
62OCT4_18555785_Chip-Seq_ESCs_Mouse1.66815434
63FOXP3_21729870_ChIP-Seq_TREG_Human1.66266501
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.65754540
65KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.65683516
66SOX2_18555785_Chip-Seq_ESCs_Mouse1.65514999
67RUNX1_27457419_Chip-Seq_LIVER_Mouse1.65284718
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.63905151
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63560625
70CBX2_27304074_Chip-Seq_ESCs_Mouse1.63088466
71PU1_27457419_Chip-Seq_LIVER_Mouse1.61330601
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60473122
73E2F1_18555785_ChIP-Seq_MESCs_Mouse1.59737353
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58459699
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.58274752
76MYC_18940864_ChIP-ChIP_HL60_Human1.56770201
77YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56693659
78ZFX_18555785_Chip-Seq_ESCs_Mouse1.56643602
79P300_18555785_Chip-Seq_ESCs_Mouse1.56486016
80IGF1R_20145208_ChIP-Seq_DFB_Human1.55960119
81TCF3_18692474_ChIP-Seq_MESCs_Mouse1.55594330
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.55530291
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.53594296
84RNF2_27304074_Chip-Seq_NSC_Mouse1.53266578
85IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51624360
86KLF4_18555785_Chip-Seq_ESCs_Mouse1.51015586
87SMAD1_18555785_Chip-Seq_ESCs_Mouse1.49967397
88HTT_18923047_ChIP-ChIP_STHdh_Human1.49854612
89ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49798722
90POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.49030924
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.48199317
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.47933578
93CTCF_18555785_Chip-Seq_ESCs_Mouse1.47455714
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44838583
95EWS_26573619_Chip-Seq_HEK293_Human1.44330676
96P300_19829295_ChIP-Seq_ESCs_Human1.42976685
97VDR_23849224_ChIP-Seq_CD4+_Human1.40094747
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.37095042
99NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.35316454
100TP53_18474530_ChIP-ChIP_U2OS_Human1.34729907
101TAF15_26573619_Chip-Seq_HEK293_Human1.34414580
102E2F7_22180533_ChIP-Seq_HELA_Human1.32852933
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32280472
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.31069928
105HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30505077
106KAP1_22055183_ChIP-Seq_ESCs_Mouse1.30255729
107GATA1_26923725_Chip-Seq_HPCs_Mouse1.30063743
108CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29954150
109STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.29849210
110AR_21909140_ChIP-Seq_LNCAP_Human1.29394576
111TTF2_22483619_ChIP-Seq_HELA_Human1.28304363
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28205119
113SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.25677953
114THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25376857
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24239202
116LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24000168
117OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23886819
118TP63_19390658_ChIP-ChIP_HaCaT_Human1.23329168
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.22716058
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22440397
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21151012
122TAL1_26923725_Chip-Seq_HPCs_Mouse1.19752744
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19632505
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16192322
125GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.15255778
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13036378
127MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12756305
128RBPJ_21746931_ChIP-Seq_IB4_Human1.11983580
129YY1_21170310_ChIP-Seq_MESCs_Mouse1.11763504
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10938517
131SRF_21415370_ChIP-Seq_HL-1_Mouse1.08372640
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08334078
133HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07473587
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06007550
135SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.05895741
136HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05407612
137ER_23166858_ChIP-Seq_MCF-7_Human1.04495256
138SMAD4_21799915_ChIP-Seq_A2780_Human1.04283486
139EED_16625203_ChIP-ChIP_MESCs_Mouse1.04157686
140DCP1A_22483619_ChIP-Seq_HELA_Human1.03651895
141POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02380682
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01406558
143ETV1_20927104_ChIP-Seq_GIST48_Human1.00233254
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99938343
145SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99913005
146FUS_26573619_Chip-Seq_HEK293_Human0.99154063
147PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.98430610
148GABP_19822575_ChIP-Seq_HepG2_Human0.98202001
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97959073
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97959073
151TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97577839
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97490909
153SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97490909
154SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97074291
155ESR1_21235772_ChIP-Seq_MCF-7_Human0.96274065
156GATA6_21074721_ChIP-Seq_CACO-2_Human0.96224181
157TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95869891
158EZH2_27304074_Chip-Seq_ESCs_Mouse0.95819858
159IRF1_19129219_ChIP-ChIP_H3396_Human0.95674785
160CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95441328
161CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93190343
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.90954537
163ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90174957
164AR_25329375_ChIP-Seq_VCAP_Human0.89792239
165XRN2_22483619_ChIP-Seq_HELA_Human0.89690157
166NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88764062
167NANOG_18692474_ChIP-Seq_MESCs_Mouse0.88618880
168PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.87915566
169AR_21572438_ChIP-Seq_LNCaP_Human0.85686738
170ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84589880
171TCF4_22108803_ChIP-Seq_LS180_Human0.84568766
172SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84419123
173NANOG_16518401_ChIP-PET_MESCs_Mouse0.83617534
174RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83220040
175E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.82251209
176TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.81964860
177NANOG_18692474_ChIP-Seq_MEFs_Mouse0.81747282
178SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79707780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003941_abnormal_skin_development5.36478377
2MP0004381_abnormal_hair_follicle4.51796091
3MP0002796_impaired_skin_barrier4.02093413
4MP0004957_abnormal_blastocyst_morpholog3.72383453
5MP0003890_abnormal_embryonic-extraembry3.54371659
6MP0003718_maternal_effect3.27257741
7MP0000566_synostosis3.25602095
8MP0001188_hyperpigmentation3.09890419
9MP0000579_abnormal_nail_morphology3.03125975
10MP0005451_abnormal_body_composition2.63180647
11MP0001835_abnormal_antigen_presentation2.60482789
12MP0005501_abnormal_skin_physiology2.55577884
13MP0002254_reproductive_system_inflammat2.55369150
14MP0002277_abnormal_respiratory_mucosa2.50000567
15MP0005275_abnormal_skin_tensile2.44670199
16MP0008932_abnormal_embryonic_tissue2.37242661
17MP0003077_abnormal_cell_cycle2.35648370
18MP0002060_abnormal_skin_morphology2.25857380
19MP0009672_abnormal_birth_weight2.23069532
20MP0005075_abnormal_melanosome_morpholog2.12734433
21MP0003567_abnormal_fetal_cardiomyocyte2.12305943
22MP0006292_abnormal_olfactory_placode2.12076403
23MP0002098_abnormal_vibrissa_morphology2.11965890
24MP0002009_preneoplasia2.11195659
25MP0001216_abnormal_epidermal_layer2.10945803
26MP0004133_heterotaxia2.05592631
27MP0009379_abnormal_foot_pigmentation2.00419427
28MP0003119_abnormal_digestive_system1.96093431
29MP0001293_anophthalmia1.95400824
30MP0010771_integument_phenotype1.87310965
31MP0005409_darkened_coat_color1.86144034
32MP0001730_embryonic_growth_arrest1.85711015
33MP0010386_abnormal_urinary_bladder1.79134749
34MP0000427_abnormal_hair_cycle1.76405793
35MP0005645_abnormal_hypothalamus_physiol1.75297407
36MP0003937_abnormal_limbs/digits/tail_de1.72925619
37MP0000647_abnormal_sebaceous_gland1.71409079
38MP0003136_yellow_coat_color1.70591392
39MP0000383_abnormal_hair_follicle1.70581974
40MP0002148_abnormal_hypersensitivity_rea1.70075244
41MP0002876_abnormal_thyroid_physiology1.65139007
42MP0001346_abnormal_lacrimal_gland1.64684963
43MP0005171_absent_coat_pigmentation1.62157593
44MP0004782_abnormal_surfactant_physiolog1.59572856
45MP0000015_abnormal_ear_pigmentation1.58831670
46MP0004947_skin_inflammation1.57174585
47MP0002132_abnormal_respiratory_system1.56729904
48MP0003878_abnormal_ear_physiology1.53126600
49MP0005377_hearing/vestibular/ear_phenot1.53126600
50MP0008877_abnormal_DNA_methylation1.52581323
51MP0003787_abnormal_imprinting1.49115383
52MP0002085_abnormal_embryonic_tissue1.48942551
53MP0002084_abnormal_developmental_patter1.48006847
54MP0001672_abnormal_embryogenesis/_devel1.47106593
55MP0005380_embryogenesis_phenotype1.47106593
56MP0000377_abnormal_hair_follicle1.46875708
57MP0005671_abnormal_response_to1.44552455
58MP0003315_abnormal_perineum_morphology1.42967108
59MP0008057_abnormal_DNA_replication1.41979811
60MP0003880_abnormal_central_pattern1.39523945
61MP0003763_abnormal_thymus_physiology1.36923057
62MP0003121_genomic_imprinting1.36052472
63MP0009785_altered_susceptibility_to1.34459832
64MP0000350_abnormal_cell_proliferation1.34429825
65MP0008058_abnormal_DNA_repair1.33898065
66MP0001984_abnormal_olfaction1.32103561
67MP0002095_abnormal_skin_pigmentation1.27937775
68MP0001919_abnormal_reproductive_system1.27360710
69MP0001697_abnormal_embryo_size1.26324397
70MP0009703_decreased_birth_body1.26026143
71MP0005387_immune_system_phenotype1.24833490
72MP0001790_abnormal_immune_system1.24833490
73MP0010352_gastrointestinal_tract_polyps1.24780716
74MP0002736_abnormal_nociception_after1.24292081
75MP0003693_abnormal_embryo_hatching1.23660690
76MP0003453_abnormal_keratinocyte_physiol1.23023890
77MP0000372_irregular_coat_pigmentation1.22617891
78MP0001485_abnormal_pinna_reflex1.18614201
79MP0002163_abnormal_gland_morphology1.18206291
80MP0003984_embryonic_growth_retardation1.17944661
81MP0010030_abnormal_orbit_morphology1.17421877
82MP0000467_abnormal_esophagus_morphology1.16420844
83MP0003195_calcinosis1.15999499
84MP0002088_abnormal_embryonic_growth/wei1.15860967
85MP0001191_abnormal_skin_condition1.15785223
86MP0006035_abnormal_mitochondrial_morpho1.14209765
87MP0004197_abnormal_fetal_growth/weight/1.13738733
88MP0001286_abnormal_eye_development1.13452340
89MP0008260_abnormal_autophagy1.12976309
90MP0002697_abnormal_eye_size1.12844475
91MP0005395_other_phenotype1.12652906
92MP0010307_abnormal_tumor_latency1.12240364
93MP0002080_prenatal_lethality1.09993085
94MP0000762_abnormal_tongue_morphology1.08579939
95MP0000367_abnormal_coat/_hair1.07735810
96MP0002090_abnormal_vision1.05048754
97MP0002111_abnormal_tail_morphology1.03712750
98MP0006072_abnormal_retinal_apoptosis1.02790675
99MP0002102_abnormal_ear_morphology1.02428622
100MP0010678_abnormal_skin_adnexa1.01320662
101MP0005174_abnormal_tail_pigmentation1.01316075
102MP0005389_reproductive_system_phenotype1.00688253
103MP0002938_white_spotting0.99920480
104MP0005646_abnormal_pituitary_gland0.98893800
105MP0010094_abnormal_chromosome_stability0.98687009
106MP0002210_abnormal_sex_determination0.97919056
107MP0002638_abnormal_pupillary_reflex0.97713703
108MP0001929_abnormal_gametogenesis0.96423329
109MP0009697_abnormal_copulation0.94688197
110MP0009931_abnormal_skin_appearance0.92859590
111MP0003786_premature_aging0.92107057
112MP0003123_paternal_imprinting0.91697697
113MP0003646_muscle_fatigue0.90997784
114MP0001186_pigmentation_phenotype0.90515212
115MP0001145_abnormal_male_reproductive0.89024453
116MP0003186_abnormal_redox_activity0.88433660
117MP0002138_abnormal_hepatobiliary_system0.88369860
118MP0005025_abnormal_response_to0.87067340
119MP0001851_eye_inflammation0.86978336
120MP0000313_abnormal_cell_death0.86403164
121MP0000049_abnormal_middle_ear0.86355612
122MP0005000_abnormal_immune_tolerance0.86210198
123MP0002751_abnormal_autonomic_nervous0.85962662
124MP0002086_abnormal_extraembryonic_tissu0.83873146
125MP0001542_abnormal_bone_strength0.83410164
126MP0001853_heart_inflammation0.83143124
127MP0003011_delayed_dark_adaptation0.82578761
128MP0005367_renal/urinary_system_phenotyp0.82336242
129MP0000516_abnormal_urinary_system0.82336242
130MP0000653_abnormal_sex_gland0.82063310
131MP0002006_tumorigenesis0.82040976
132MP0000685_abnormal_immune_system0.81711790
133MP0001177_atelectasis0.81411330
134MP0001800_abnormal_humoral_immune0.81400521
135MP0003861_abnormal_nervous_system0.80769592
136MP0002735_abnormal_chemical_nociception0.80394019
137MP0002452_abnormal_antigen_presenting0.79500008
138MP0008770_decreased_survivor_rate0.77579862
139MP0000538_abnormal_urinary_bladder0.77387914
140MP0001819_abnormal_immune_cell0.77303802
141MP0001119_abnormal_female_reproductive0.77164899
142MP0001873_stomach_inflammation0.77077122
143MP0002233_abnormal_nose_morphology0.76302399
144MP0002177_abnormal_outer_ear0.75885263
145MP0008007_abnormal_cellular_replicative0.75437546
146MP0003698_abnormal_male_reproductive0.74668546
147MP0009764_decreased_sensitivity_to0.74413508
148MP0002160_abnormal_reproductive_system0.73842550
149MP0002420_abnormal_adaptive_immunity0.73701581
150MP0000537_abnormal_urethra_morphology0.73667031
151MP0005379_endocrine/exocrine_gland_phen0.73261230
152MP0004147_increased_porphyrin_level0.73247622
153MP0002723_abnormal_immune_serum0.73059981
154MP0008872_abnormal_physiological_respon0.71763247
155MP0003111_abnormal_nucleus_morphology0.71685812
156MP0005551_abnormal_eye_electrophysiolog0.70765500
157MP0003183_abnormal_peptide_metabolism0.68324022
158MP0005394_taste/olfaction_phenotype0.67776664
159MP0005499_abnormal_olfactory_system0.67776664
160MP0008789_abnormal_olfactory_epithelium0.67689203
161MP0001243_abnormal_dermal_layer0.67057703
162MP0002419_abnormal_innate_immunity0.66731271
163MP0000428_abnormal_craniofacial_morphol0.66456433
164MP0001968_abnormal_touch/_nociception0.65660687
165MP0001529_abnormal_vocalization0.65395970
166MP0004264_abnormal_extraembryonic_tissu0.65356690
167MP0003806_abnormal_nucleotide_metabolis0.64601771
168MP0000432_abnormal_head_morphology0.64518512
169MP0001324_abnormal_eye_pigmentation0.62878453
170MP0002161_abnormal_fertility/fecundity0.60905182
171MP0000358_abnormal_cell_content/0.60166571
172MP0005410_abnormal_fertilization0.60161297
173MP0003699_abnormal_female_reproductive0.59289746
174MP0005253_abnormal_eye_physiology0.58029903
175MP0000631_abnormal_neuroendocrine_gland0.55440242
176MP0005647_abnormal_sex_gland0.53307752

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)5.00503621
2Abnormality of the labia minora (HP:0012880)4.88852407
3Lip pit (HP:0100267)4.68956816
4Colon cancer (HP:0003003)4.49239865
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.78906617
6Increased IgE level (HP:0003212)3.76052700
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73038478
8Palmoplantar hyperkeratosis (HP:0000972)3.72439283
9Palmar hyperkeratosis (HP:0010765)3.71669815
10Congenital ichthyosiform erythroderma (HP:0007431)3.66075502
11Plantar hyperkeratosis (HP:0007556)3.55241335
12Parakeratosis (HP:0001036)3.52012170
13Prostate neoplasm (HP:0100787)3.47355815
14Chromsome breakage (HP:0040012)3.31542528
15Chronic bronchitis (HP:0004469)3.23094766
16Dry hair (HP:0011359)3.20407753
17Abnormal hair whorl (HP:0010721)3.18296642
18Onycholysis (HP:0001806)3.18151813
19Natal tooth (HP:0000695)3.15878206
20Abnormality of secondary sexual hair (HP:0009888)3.13170446
21Abnormality of the axillary hair (HP:0100134)3.13170446
22Nephroblastoma (Wilms tumor) (HP:0002667)3.12555468
23Bilateral microphthalmos (HP:0007633)3.08345624
24Ependymoma (HP:0002888)2.98525849
25Erythema (HP:0010783)2.96299306
26Embryonal renal neoplasm (HP:0011794)2.95570604
27Hypotrichosis (HP:0001006)2.92985152
28Erythroderma (HP:0001019)2.92784998
29True hermaphroditism (HP:0010459)2.89606945
30Meckel diverticulum (HP:0002245)2.86757975
31Thick nail (HP:0001805)2.84898882
32Abnormal lung lobation (HP:0002101)2.78431792
33Abnormality of the ileum (HP:0001549)2.77147574
34Eczematoid dermatitis (HP:0000976)2.75068967
35Sparse eyelashes (HP:0000653)2.71592137
36Abnormality of the renal collecting system (HP:0004742)2.70823727
37Ectropion (HP:0000656)2.66292354
38Hyperglycinuria (HP:0003108)2.65509151
39Spastic diplegia (HP:0001264)2.65094440
40Sparse scalp hair (HP:0002209)2.61512461
41Hyperglycinemia (HP:0002154)2.58682385
42Hepatoblastoma (HP:0002884)2.58148467
43Abnormality of chromosome stability (HP:0003220)2.56191454
44Conical tooth (HP:0000698)2.56053154
45Absent radius (HP:0003974)2.54019469
46Multiple enchondromatosis (HP:0005701)2.52755864
47Duplicated collecting system (HP:0000081)2.52188703
48Abnormality of the preputium (HP:0100587)2.50608649
49Abnormality of serum amino acid levels (HP:0003112)2.49989791
50Popliteal pterygium (HP:0009756)2.49394467
51Retrobulbar optic neuritis (HP:0100654)2.47859840
52Optic neuritis (HP:0100653)2.47859840
53Abnormality of glycine metabolism (HP:0010895)2.47467136
54Abnormality of serine family amino acid metabolism (HP:0010894)2.47467136
55Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46840773
56Stenosis of the external auditory canal (HP:0000402)2.46634914
57Alveolar cell carcinoma (HP:0006519)2.44685102
58Abnormality of homocysteine metabolism (HP:0010919)2.42463856
59Homocystinuria (HP:0002156)2.42463856
60Aplasia involving forearm bones (HP:0009822)2.40553897
61Absent forearm bone (HP:0003953)2.40553897
62Carpal bone hypoplasia (HP:0001498)2.39290796
63Rhabdomyosarcoma (HP:0002859)2.38929785
64Abnormality of abdominal situs (HP:0011620)2.35863182
65Abdominal situs inversus (HP:0003363)2.35863182
66Abnormality of incisor morphology (HP:0011063)2.35838587
67Absent septum pellucidum (HP:0001331)2.33958953
68Abnormal blistering of the skin (HP:0008066)2.33719291
69Pendular nystagmus (HP:0012043)2.31104805
70Biliary tract neoplasm (HP:0100574)2.30618496
71Abnormality of the septum pellucidum (HP:0007375)2.29894144
72Pruritus (HP:0000989)2.29710112
73Neoplasm of the adrenal cortex (HP:0100641)2.27775566
74Gangrene (HP:0100758)2.26743397
75Recurrent abscess formation (HP:0002722)2.26673575
76Pancreatic fibrosis (HP:0100732)2.24816624
77Corneal dystrophy (HP:0001131)2.24490899
78Supernumerary spleens (HP:0009799)2.24327662
79Choanal stenosis (HP:0000452)2.23277451
80Agnosia (HP:0010524)2.23108487
81Woolly hair (HP:0002224)2.22893670
82Type 2 muscle fiber atrophy (HP:0003554)2.21343263
83Hypoplasia of the pons (HP:0012110)2.20705025
84Aplasia/hypoplasia of the uterus (HP:0008684)2.17299956
85Hypohidrosis (HP:0000966)2.15203847
86Maternal diabetes (HP:0009800)2.13558543
87Glioma (HP:0009733)2.11731981
88Selective tooth agenesis (HP:0001592)2.10235582
89Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09120390
90Horseshoe kidney (HP:0000085)2.07888253
91Recurrent bacterial skin infections (HP:0005406)2.07472275
92Abnormality of the prostate (HP:0008775)2.06852463
93Duodenal stenosis (HP:0100867)2.06810920
94Small intestinal stenosis (HP:0012848)2.06810920
95Neoplasm of the colon (HP:0100273)2.06790644
96Abolished electroretinogram (ERG) (HP:0000550)2.06412869
97Optic nerve hypoplasia (HP:0000609)2.05800832
98Azoospermia (HP:0000027)2.05520511
99Abnormality of the pons (HP:0007361)2.03627592
100Fragile nails (HP:0001808)2.02765381
101Ectopic kidney (HP:0000086)2.02724754
102Eosinophilia (HP:0001880)2.02132713
103Absent eyebrow (HP:0002223)2.01179842
104Pancreatic islet-cell hyperplasia (HP:0004510)2.01081168
105Abnormality of the duodenum (HP:0002246)2.00931292
106Medulloblastoma (HP:0002885)2.00730171
107Impulsivity (HP:0100710)2.00023226
108Cortical dysplasia (HP:0002539)1.97990540
109Corneal erosion (HP:0200020)1.97366387
110Febrile seizures (HP:0002373)1.96918730
111Oral leukoplakia (HP:0002745)1.96726811
112Increased IgM level (HP:0003496)1.96441542
113Breast aplasia (HP:0100783)1.95732022
114Type I transferrin isoform profile (HP:0003642)1.95351494
115Abnormality of the clitoris (HP:0000056)1.95287203
116Neoplasm of the adrenal gland (HP:0100631)1.94866607
117Bifid tongue (HP:0010297)1.94167307
118Cellular immunodeficiency (HP:0005374)1.94144202
119Neoplasm of the tracheobronchial system (HP:0100552)1.93477466
120Xerostomia (HP:0000217)1.93396987
121Gonadotropin excess (HP:0000837)1.92929575
122Hypergammaglobulinemia (HP:0010702)1.92893489
123Aplasia/Hypoplasia of the sternum (HP:0006714)1.92425306
124Chronic obstructive pulmonary disease (HP:0006510)1.92395698
125Obstructive lung disease (HP:0006536)1.92395698
126Septo-optic dysplasia (HP:0100842)1.91828539
127Orchitis (HP:0100796)1.91562550
128Clitoromegaly (HP:0000057)1.90822053
129Aplasia/Hypoplasia of the uvula (HP:0010293)1.90574331
130Median cleft lip (HP:0000161)1.90489791
131Curly hair (HP:0002212)1.89870249
132Keratoconjunctivitis (HP:0001096)1.89869432
133Abnormal spermatogenesis (HP:0008669)1.88084749
134Hypoplastic female external genitalia (HP:0012815)1.88081746
135Abnormality of DNA repair (HP:0003254)1.87574071
136Intestinal atresia (HP:0011100)1.87335865
137Reticulocytopenia (HP:0001896)1.86875006
138Sloping forehead (HP:0000340)1.86809646
139Nasolacrimal duct obstruction (HP:0000579)1.86128166
140Granulocytopenia (HP:0001913)1.85758881
141Facial cleft (HP:0002006)1.85709383
142Stomach cancer (HP:0012126)1.85376289
143Methylmalonic acidemia (HP:0002912)1.85294381
144Clubbing of toes (HP:0100760)1.85091819
145Myositis (HP:0100614)1.85026996
146Glomerulopathy (HP:0100820)1.84897171
147Hypoglycemic seizures (HP:0002173)1.83642596
148Abnormality of male internal genitalia (HP:0000022)1.83333706
149Testicular atrophy (HP:0000029)1.83216696
150Keratoconjunctivitis sicca (HP:0001097)1.82645414
151Patchy hypopigmentation of hair (HP:0011365)1.82420515
152Aqueductal stenosis (HP:0002410)1.81378241
153Pancreatic cysts (HP:0001737)1.80591088
154Mediastinal lymphadenopathy (HP:0100721)1.80553612
155Triphalangeal thumb (HP:0001199)1.79945698
156Short hallux (HP:0010109)1.78902696
157Right ventricular cardiomyopathy (HP:0011663)1.78688377
158Abnormality of the nasal septum (HP:0000419)1.78670075
159Abnormality of methionine metabolism (HP:0010901)1.78229252
160Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.77115650
161Congenital, generalized hypertrichosis (HP:0004540)1.76862247
162Hypothermia (HP:0002045)1.76619064
163Prolonged neonatal jaundice (HP:0006579)1.76557717
164Aplasia/Hypoplasia of the breasts (HP:0010311)1.76310702
165Labial hypoplasia (HP:0000066)1.75936773
166Male pseudohermaphroditism (HP:0000037)1.75773422
167Birth length less than 3rd percentile (HP:0003561)1.75456896
168Advanced eruption of teeth (HP:0006288)1.75357191
169Esophageal atresia (HP:0002032)1.74904619
170Abnormality of the astrocytes (HP:0100707)1.74332976
171Astrocytoma (HP:0009592)1.74332976
172Methylmalonic aciduria (HP:0012120)1.74198823
173Chronic hepatic failure (HP:0100626)1.73870432
174Ridged nail (HP:0001807)1.73816180
175Gastrointestinal carcinoma (HP:0002672)1.72753068
176Malignant gastrointestinal tract tumors (HP:0006749)1.72753068
177Rectal fistula (HP:0100590)1.72550380
178Rectovaginal fistula (HP:0000143)1.72550380
179Muscle fiber atrophy (HP:0100295)1.72108732
180Nail dystrophy (HP:0008404)1.71660710
181Dandy-Walker malformation (HP:0001305)1.71537068
182Fused cervical vertebrae (HP:0002949)1.70871997
183Abnormality of sulfur amino acid metabolism (HP:0004339)1.70779464
184Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.70583351
185Hypergonadotropic hypogonadism (HP:0000815)1.70426521
186Abnormality of eosinophils (HP:0001879)1.70162356
187Aplasia/Hypoplasia of the hallux (HP:0008362)1.70099832
188Renal cortical cysts (HP:0000803)1.69377767
189Aplastic anemia (HP:0001915)1.69209733

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.08010268
2CDC73.65093552
3IRAK33.49464389
4TTK3.40617880
5MST42.91283948
6ZAK2.86725662
7VRK22.83043400
8MAP3K142.79608668
9STK162.70323825
10AKT32.62286278
11ERBB32.53419324
12TAF12.38874296
13IRAK42.34272262
14SRPK12.33744318
15SIK32.13871130
16BMPR22.10935961
17EIF2AK22.06816390
18TXK1.95308467
19PLK41.92880738
20EIF2AK31.83044739
21WNK31.78517090
22TRIM281.72502276
23MAP2K71.68334784
24YES11.64966505
25PLK11.56812060
26TNK21.56766599
27IKBKB1.55384362
28NUAK11.54177995
29TRPM71.51394822
30BRSK21.45916306
31FRK1.44798703
32STK241.44217456
33EIF2AK11.43734038
34VRK11.37278552
35IRAK11.35704465
36BCR1.34473350
37IRAK21.33087700
38MAP3K31.31307202
39ERBB41.30239051
40STK31.29619609
41SGK21.28901146
42OXSR11.28689874
43NEK61.28024964
44CDK31.27562959
45NEK21.26905572
46ALK1.22227905
47CHEK21.19868774
48NEK11.18014478
49TEC1.15706758
50GRK11.14647306
51GRK71.13240079
52PASK1.10558884
53MAP3K121.09330958
54IKBKE1.08538518
55MAPKAPK31.08255927
56CHUK1.06971234
57CDK81.06813711
58DYRK31.02274558
59PIM21.02259010
60ADRBK21.00199795
61STK38L0.94643623
62PINK10.94443271
63FGFR10.92242426
64MKNK20.90530933
65BMPR1B0.90314629
66CCNB10.88036170
67SMG10.87771080
68MAP3K90.87144602
69CLK10.86097763
70ATM0.85149560
71CSNK1G10.82554994
72LATS10.81842724
73CHEK10.80064481
74CDK190.78942292
75MAP2K60.78917699
76TIE10.78728714
77BUB10.78132789
78PRPF4B0.77820784
79MAPK130.76206482
80CAMK1D0.76107054
81FGFR20.75304244
82FER0.74161889
83MAP3K100.74028236
84PRKCE0.72553684
85MKNK10.71760940
86CAMK1G0.70351912
87KDR0.69531328
88MAP3K60.69016277
89BTK0.66493163
90JAK30.66108034
91TSSK60.65925862
92INSRR0.65658870
93PLK20.63322962
94BRSK10.62415645
95RPS6KA40.60938019
96NLK0.60053511
97PBK0.59618444
98DYRK20.59423328
99PNCK0.58420739
100NME10.57924050
101TNIK0.56335213
102EPHA30.55698422
103SGK4940.55263639
104SGK2230.55263639
105CSNK1E0.55220607
106LATS20.53944254
107BMX0.53299561
108EPHA20.53197487
109TGFBR10.52709461
110DAPK10.52623193
111SGK30.52133775
112CDK10.51800878
113RPS6KB10.51633504
114CSNK1G20.50757928
115MAP3K50.49971670
116FLT30.49608445
117RIPK40.49358378
118CDK120.48706077
119TYK20.48307877
120CDK20.48137176
121TAOK20.46448307
122PRKDC0.46354897
123DYRK1A0.44740109
124CSNK2A10.44588336
125NEK90.44439207
126BRD40.44194284
127MAP3K40.43708882
128WNK40.43400269
129ACVR1B0.43388414
130EPHA40.43089651
131PLK30.41791296
132JAK10.40505100
133RPS6KB20.40472694
134PIM10.40276897
135ATR0.40136999
136MAP3K80.39729809
137PAK40.39618827
138MAPK70.39312686
139CSNK1G30.39069468
140EGFR0.39004420
141PDK20.38574815
142FGFR30.38567125
143ITK0.38443628
144CSNK2A20.38167751
145WEE10.36797641
146AURKA0.36780922
147CDK70.36322489
148BRAF0.35799381
149STK40.35700677
150LYN0.35004089
151MAP4K20.34606276
152PRKCI0.33175171
153CSNK1A1L0.32981702
154MST1R0.32153962
155MELK0.31645243
156MARK10.30604833
157AURKB0.30015809
158FGFR40.29767194
159CSNK1D0.29470451

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053322.74574749
2RNA polymerase_Homo sapiens_hsa030202.63163525
3Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.58875189
4Selenocompound metabolism_Homo sapiens_hsa004502.58477053
5Sphingolipid metabolism_Homo sapiens_hsa006002.57189497
6One carbon pool by folate_Homo sapiens_hsa006702.47025972
7Cysteine and methionine metabolism_Homo sapiens_hsa002702.43402337
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42998365
9Homologous recombination_Homo sapiens_hsa034402.40520247
10Proteasome_Homo sapiens_hsa030502.36178635
11Arachidonic acid metabolism_Homo sapiens_hsa005902.07245831
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.02095581
13Allograft rejection_Homo sapiens_hsa053301.96965780
14Fanconi anemia pathway_Homo sapiens_hsa034601.93581514
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77899636
16Intestinal immune network for IgA production_Homo sapiens_hsa046721.70786346
17Mismatch repair_Homo sapiens_hsa034301.67413523
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.60306226
19Base excision repair_Homo sapiens_hsa034101.58973044
20DNA replication_Homo sapiens_hsa030301.58222756
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.58221783
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57922786
23Pyrimidine metabolism_Homo sapiens_hsa002401.51162184
24Linoleic acid metabolism_Homo sapiens_hsa005911.50527639
25Autoimmune thyroid disease_Homo sapiens_hsa053201.48512621
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43805511
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43483386
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40970738
29Propanoate metabolism_Homo sapiens_hsa006401.40672764
30Regulation of autophagy_Homo sapiens_hsa041401.39693378
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38816278
32Rheumatoid arthritis_Homo sapiens_hsa053231.37229033
33Non-homologous end-joining_Homo sapiens_hsa034501.37203177
34Protein export_Homo sapiens_hsa030601.37064891
35Primary immunodeficiency_Homo sapiens_hsa053401.34279459
36Ribosome_Homo sapiens_hsa030101.34100692
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.34039992
38Collecting duct acid secretion_Homo sapiens_hsa049661.33236245
39Pyruvate metabolism_Homo sapiens_hsa006201.32748460
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.31447354
41Asthma_Homo sapiens_hsa053101.30956651
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30580363
43Basal transcription factors_Homo sapiens_hsa030221.29864790
44Nicotine addiction_Homo sapiens_hsa050331.28485652
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.26623849
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.24264028
47NF-kappa B signaling pathway_Homo sapiens_hsa040641.24068530
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.22155919
49Steroid biosynthesis_Homo sapiens_hsa001001.21904105
50Nucleotide excision repair_Homo sapiens_hsa034201.20775942
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20011808
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19949967
53Biosynthesis of amino acids_Homo sapiens_hsa012301.19757717
54Phototransduction_Homo sapiens_hsa047441.19274904
55NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19089325
56Herpes simplex infection_Homo sapiens_hsa051681.18053940
57Huntingtons disease_Homo sapiens_hsa050161.11523421
58RNA degradation_Homo sapiens_hsa030181.11063983
59Measles_Homo sapiens_hsa051621.10140921
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09709891
61Hematopoietic cell lineage_Homo sapiens_hsa046401.07308541
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06742127
63Purine metabolism_Homo sapiens_hsa002301.05696653
64Ether lipid metabolism_Homo sapiens_hsa005651.04118104
65Spliceosome_Homo sapiens_hsa030401.03696268
66p53 signaling pathway_Homo sapiens_hsa041151.03188015
672-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02552057
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01074134
69Parkinsons disease_Homo sapiens_hsa050120.98548730
70Oocyte meiosis_Homo sapiens_hsa041140.93551809
71Legionellosis_Homo sapiens_hsa051340.93071407
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.92280335
73Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91777899
74Type I diabetes mellitus_Homo sapiens_hsa049400.91149922
75Oxidative phosphorylation_Homo sapiens_hsa001900.90320610
76Glutathione metabolism_Homo sapiens_hsa004800.89628042
77Phenylalanine metabolism_Homo sapiens_hsa003600.89052837
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87734588
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86800570
80Antigen processing and presentation_Homo sapiens_hsa046120.86126734
81Influenza A_Homo sapiens_hsa051640.83989671
82TNF signaling pathway_Homo sapiens_hsa046680.83621046
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.83551563
84Leishmaniasis_Homo sapiens_hsa051400.82628654
85Tight junction_Homo sapiens_hsa045300.81228246
86Fatty acid elongation_Homo sapiens_hsa000620.78863873
87Vitamin digestion and absorption_Homo sapiens_hsa049770.78559385
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77803515
89Pertussis_Homo sapiens_hsa051330.76769408
90Phagosome_Homo sapiens_hsa041450.76672168
91African trypanosomiasis_Homo sapiens_hsa051430.76657941
92Vitamin B6 metabolism_Homo sapiens_hsa007500.76363451
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.74692303
94Epstein-Barr virus infection_Homo sapiens_hsa051690.74285857
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73848242
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72484941
97Lysine degradation_Homo sapiens_hsa003100.72342862
98Carbon metabolism_Homo sapiens_hsa012000.71989214
99Olfactory transduction_Homo sapiens_hsa047400.71534705
100Wnt signaling pathway_Homo sapiens_hsa043100.70293544
101Histidine metabolism_Homo sapiens_hsa003400.69078216
102Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68764507
103Adherens junction_Homo sapiens_hsa045200.68403583
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67154989
105Arginine and proline metabolism_Homo sapiens_hsa003300.67141992
106Basal cell carcinoma_Homo sapiens_hsa052170.66337713
107Hippo signaling pathway_Homo sapiens_hsa043900.64398911
108Metabolic pathways_Homo sapiens_hsa011000.63153764
109Malaria_Homo sapiens_hsa051440.62905319
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61894506
111Cell cycle_Homo sapiens_hsa041100.60680469
112Thyroid cancer_Homo sapiens_hsa052160.60034021
113Folate biosynthesis_Homo sapiens_hsa007900.59375787
114Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59310888
115RNA transport_Homo sapiens_hsa030130.58434169
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57517776
117Tuberculosis_Homo sapiens_hsa051520.57068692
118Taste transduction_Homo sapiens_hsa047420.55059641
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54734064
120Tryptophan metabolism_Homo sapiens_hsa003800.54443980
121Retinol metabolism_Homo sapiens_hsa008300.54350814
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53551023
123Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53463633
124Apoptosis_Homo sapiens_hsa042100.52055462
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49262035
126Hepatitis C_Homo sapiens_hsa051600.49219288
127T cell receptor signaling pathway_Homo sapiens_hsa046600.47908454
128Other glycan degradation_Homo sapiens_hsa005110.47216269
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46701879
130Circadian rhythm_Homo sapiens_hsa047100.46435833
131beta-Alanine metabolism_Homo sapiens_hsa004100.44350475
132Vibrio cholerae infection_Homo sapiens_hsa051100.43259565
133TGF-beta signaling pathway_Homo sapiens_hsa043500.42124582
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41937172
135Butanoate metabolism_Homo sapiens_hsa006500.40958156
136Shigellosis_Homo sapiens_hsa051310.40465170
137Serotonergic synapse_Homo sapiens_hsa047260.40395118
138Morphine addiction_Homo sapiens_hsa050320.38196153
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36920976
140Alzheimers disease_Homo sapiens_hsa050100.36498704
141mRNA surveillance pathway_Homo sapiens_hsa030150.35866120
142Osteoclast differentiation_Homo sapiens_hsa043800.33447836
143Caffeine metabolism_Homo sapiens_hsa002320.30602099
144Fatty acid degradation_Homo sapiens_hsa000710.30325453
145Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30211791
146Starch and sucrose metabolism_Homo sapiens_hsa005000.30018028
147Notch signaling pathway_Homo sapiens_hsa043300.29828674
148Chemokine signaling pathway_Homo sapiens_hsa040620.29696363
149Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29233827
150Hepatitis B_Homo sapiens_hsa051610.29212029
151Nitrogen metabolism_Homo sapiens_hsa009100.29073409
152Fat digestion and absorption_Homo sapiens_hsa049750.25489644
153Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.25222658
154Peroxisome_Homo sapiens_hsa041460.25112055
155Hedgehog signaling pathway_Homo sapiens_hsa043400.24860118
156Chemical carcinogenesis_Homo sapiens_hsa052040.24668397
157Fatty acid metabolism_Homo sapiens_hsa012120.23831699
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.22686356

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »