ABHD14B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.28085022
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.28085022
3L-phenylalanine metabolic process (GO:0006558)7.01306970
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.01306970
5aromatic amino acid family catabolic process (GO:0009074)6.58379482
6indole-containing compound catabolic process (GO:0042436)5.96590913
7indolalkylamine catabolic process (GO:0046218)5.96590913
8tryptophan catabolic process (GO:0006569)5.96590913
9glyoxylate metabolic process (GO:0046487)5.80598473
10cysteine metabolic process (GO:0006534)5.71844766
11kynurenine metabolic process (GO:0070189)5.68434515
12tryptophan metabolic process (GO:0006568)5.65005937
13bile acid biosynthetic process (GO:0006699)5.42567878
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.42411291
15sulfur amino acid catabolic process (GO:0000098)5.39709311
16lysine catabolic process (GO:0006554)5.37176953
17lysine metabolic process (GO:0006553)5.37176953
18alpha-linolenic acid metabolic process (GO:0036109)5.05412529
19serine family amino acid catabolic process (GO:0009071)4.97540995
20urea metabolic process (GO:0019627)4.91105402
21urea cycle (GO:0000050)4.91105402
22homocysteine metabolic process (GO:0050667)4.90173179
23high-density lipoprotein particle remodeling (GO:0034375)4.85099767
24fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.83209737
25aromatic amino acid family metabolic process (GO:0009072)4.81501662
26amino-acid betaine metabolic process (GO:0006577)4.74392794
27bile acid metabolic process (GO:0008206)4.60855923
28protein carboxylation (GO:0018214)4.57463317
29peptidyl-glutamic acid carboxylation (GO:0017187)4.57463317
30negative regulation of fibrinolysis (GO:0051918)4.57044941
31nitrogen cycle metabolic process (GO:0071941)4.56732860
32alpha-amino acid catabolic process (GO:1901606)4.55546642
33cellular ketone body metabolic process (GO:0046950)4.50041338
34tyrosine metabolic process (GO:0006570)4.49567980
35regulation of fibrinolysis (GO:0051917)4.46188415
36drug transmembrane transport (GO:0006855)4.41433539
37complement activation, alternative pathway (GO:0006957)4.41297383
38urate metabolic process (GO:0046415)4.37413589
39cellular modified amino acid catabolic process (GO:0042219)4.36545914
40regulation of protein activation cascade (GO:2000257)4.31832002
41glutamate metabolic process (GO:0006536)4.30643978
42drug catabolic process (GO:0042737)4.29930322
43cellular amino acid catabolic process (GO:0009063)4.29890599
44reverse cholesterol transport (GO:0043691)4.29018859
45benzene-containing compound metabolic process (GO:0042537)4.27689952
46regulation of cholesterol esterification (GO:0010872)4.26350480
47indolalkylamine metabolic process (GO:0006586)4.26170338
48regulation of triglyceride catabolic process (GO:0010896)4.24851368
49cellular glucuronidation (GO:0052695)4.22551914
50short-chain fatty acid metabolic process (GO:0046459)4.21708806
51amine catabolic process (GO:0009310)4.17931746
52cellular biogenic amine catabolic process (GO:0042402)4.17931746
53serine family amino acid metabolic process (GO:0009069)4.16589344
54plasma lipoprotein particle remodeling (GO:0034369)4.15754077
55protein-lipid complex remodeling (GO:0034368)4.15754077
56macromolecular complex remodeling (GO:0034367)4.15754077
57antigen processing and presentation of endogenous antigen (GO:0019883)4.12958736
58antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.12856945
59coenzyme catabolic process (GO:0009109)4.12127978
60acylglycerol homeostasis (GO:0055090)4.11241436
61triglyceride homeostasis (GO:0070328)4.11241436
62negative regulation of cholesterol transport (GO:0032375)4.10417199
63negative regulation of sterol transport (GO:0032372)4.10417199
64regulation of complement activation (GO:0030449)4.04171792
65negative regulation of erythrocyte differentiation (GO:0045647)4.00591226
66ethanol oxidation (GO:0006069)3.98612705
67phospholipid efflux (GO:0033700)3.97095507
68aspartate family amino acid catabolic process (GO:0009068)3.93700464
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.93531622
70antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.89117766
71bile acid and bile salt transport (GO:0015721)3.88827070
72ketone body metabolic process (GO:1902224)3.88431182
73serine family amino acid biosynthetic process (GO:0009070)3.88131135
74response to nitrosative stress (GO:0051409)3.87878419
752-oxoglutarate metabolic process (GO:0006103)3.87113003
76uronic acid metabolic process (GO:0006063)3.85974572
77glucuronate metabolic process (GO:0019585)3.85974572
78glycine metabolic process (GO:0006544)3.85134709
79organic acid catabolic process (GO:0016054)3.83212883
80carboxylic acid catabolic process (GO:0046395)3.83212883
81exogenous drug catabolic process (GO:0042738)3.81343913
82regulation of cholesterol homeostasis (GO:2000188)3.81321655
83aldehyde catabolic process (GO:0046185)3.77006840
84plasma lipoprotein particle clearance (GO:0034381)3.75766793
85drug transport (GO:0015893)3.74932496
86regulation of bile acid biosynthetic process (GO:0070857)3.74522558
87valine metabolic process (GO:0006573)3.73707844
88dicarboxylic acid biosynthetic process (GO:0043650)3.73135736
89acetyl-CoA metabolic process (GO:0006084)3.72853002
90carnitine metabolic process (GO:0009437)3.70774647
91fatty acid beta-oxidation (GO:0006635)3.68591793
92fatty acid oxidation (GO:0019395)3.65971369
93imidazole-containing compound metabolic process (GO:0052803)3.63921672
94positive regulation of gamma-delta T cell activation (GO:0046645)3.63170085
95monocarboxylic acid catabolic process (GO:0072329)3.62152918
96cholesterol efflux (GO:0033344)3.62081796
97lipid oxidation (GO:0034440)3.60618396
98arginine metabolic process (GO:0006525)3.59268801
99flavonoid metabolic process (GO:0009812)3.55860800
100low-density lipoprotein particle remodeling (GO:0034374)3.54502238
101xenobiotic catabolic process (GO:0042178)3.51218860
102fatty acid catabolic process (GO:0009062)3.50603667
103drug metabolic process (GO:0017144)3.48165810
104phospholipid homeostasis (GO:0055091)3.43230940
105plasma lipoprotein particle assembly (GO:0034377)3.40498731
106response to mercury ion (GO:0046689)3.40023637
107detection of bacterium (GO:0016045)3.37397750
108NADH metabolic process (GO:0006734)3.17009808
109detection of other organism (GO:0098543)3.10242630
110positive regulation of triglyceride lipase activity (GO:0061365)3.06572524
111positive regulation of lipoprotein lipase activity (GO:0051006)3.06572524
112NIK/NF-kappaB signaling (GO:0038061)3.04333147
113regulation of gamma-delta T cell differentiation (GO:0045586)3.03791375
114pinocytosis (GO:0006907)2.97603817
115regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.95478466
116immunoglobulin mediated immune response (GO:0016064)2.94274442
117positive regulation of B cell differentiation (GO:0045579)2.91678592
118epoxygenase P450 pathway (GO:0019373)2.85165520
119proline biosynthetic process (GO:0006561)2.83314113
120neutrophil activation involved in immune response (GO:0002283)2.82579309
121regulation of gamma-delta T cell activation (GO:0046643)2.80046539
122oxaloacetate metabolic process (GO:0006107)2.79267881
123response to thyroid hormone (GO:0097066)2.71122760
124negative regulation of cell killing (GO:0031342)2.67385738
125negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.67385738
126positive regulation of fatty acid biosynthetic process (GO:0045723)2.65445553
127Golgi transport vesicle coating (GO:0048200)2.61625172
128COPI coating of Golgi vesicle (GO:0048205)2.61625172
129positive thymic T cell selection (GO:0045059)2.56977587
130ethanol metabolic process (GO:0006067)2.56484837
131regulation of superoxide anion generation (GO:0032928)2.56389948
132proline metabolic process (GO:0006560)2.54515174
133tricarboxylic acid metabolic process (GO:0072350)2.52264042
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48676997
135mature B cell differentiation involved in immune response (GO:0002313)2.45990637
136angiotensin maturation (GO:0002003)2.45640894
137detection of external biotic stimulus (GO:0098581)2.44468352
138GDP-mannose metabolic process (GO:0019673)2.41589686
139B cell receptor signaling pathway (GO:0050853)2.41498353
140Peyers patch development (GO:0048541)2.39107815
141mucosal-associated lymphoid tissue development (GO:0048537)2.39107815
142mannose metabolic process (GO:0006013)2.37833594
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.35595058
144B cell mediated immunity (GO:0019724)2.33772870
145regulation of antigen processing and presentation (GO:0002577)2.33158030
146regulation of dendritic cell antigen processing and presentation (GO:0002604)2.32831548
147response to peptidoglycan (GO:0032494)2.32567328
148modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32474274
149positive regulation by organism of defense response of other organism involved in symbiotic interact2.32474274
150modulation by symbiont of host immune response (GO:0052553)2.32474274
151positive regulation by symbiont of host defense response (GO:0052509)2.32474274
152modulation by symbiont of host defense response (GO:0052031)2.32474274
153modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32474274
154glutamine family amino acid biosynthetic process (GO:0009084)2.31503591
155complement activation, classical pathway (GO:0006958)2.31308952
156pentose-phosphate shunt (GO:0006098)2.31059112
157regulation of necrotic cell death (GO:0010939)2.30465735
158peptide catabolic process (GO:0043171)2.28766851
159negative regulation of phagocytosis (GO:0050765)2.28440458
160positive regulation of granulocyte differentiation (GO:0030854)2.27033805
161deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.25222501
162triglyceride catabolic process (GO:0019433)2.24478842
163thymic T cell selection (GO:0045061)2.24228790
164regulation of extracellular matrix disassembly (GO:0010715)2.24142156
165acute-phase response (GO:0006953)2.24134406
166response to type I interferon (GO:0034340)2.23727662
167Arp2/3 complex-mediated actin nucleation (GO:0034314)2.23570962
168type I interferon signaling pathway (GO:0060337)2.22906526
169cellular response to type I interferon (GO:0071357)2.22906526
170complement activation (GO:0006956)2.22064468
171regulation of humoral immune response (GO:0002920)2.21398650
172regulation of B cell receptor signaling pathway (GO:0050855)2.19542084
173negative thymic T cell selection (GO:0045060)2.19155444
174fat-soluble vitamin biosynthetic process (GO:0042362)2.18946850
175pentose metabolic process (GO:0019321)2.17828962
176negative regulation of granulocyte differentiation (GO:0030853)2.16654693
177protein activation cascade (GO:0072376)2.16337736
178blood coagulation, intrinsic pathway (GO:0007597)2.15491854
179positive regulation of extracellular matrix organization (GO:1903055)2.15436880
180diacylglycerol metabolic process (GO:0046339)2.15070257
181definitive hemopoiesis (GO:0060216)2.12977533

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.92820903
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.78607399
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.14244060
4LXR_22158963_ChIP-Seq_LIVER_Mouse6.08095612
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.97201366
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.89672417
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.61203698
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.72512929
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.70980773
10VDR_21846776_ChIP-Seq_THP-1_Human2.76066301
11MYC_22102868_ChIP-Seq_BL_Human2.46829877
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16114382
13TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07411355
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06288037
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.05280578
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02712349
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.0330268
18TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98971716
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96981806
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94938859
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94719203
22VDR_24763502_ChIP-Seq_THP-1_Human1.91653406
23CLOCK_20551151_ChIP-Seq_293T_Human1.89096611
24MAF_26560356_Chip-Seq_TH1_Human1.84585942
25BP1_19119308_ChIP-ChIP_Hs578T_Human1.80346768
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.72343095
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70851625
28UTX_26944678_Chip-Seq_JUKART_Human1.68736247
29SCL_19346495_ChIP-Seq_HPC-7_Human1.68659121
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.67948706
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67811240
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.67745087
33TCF7_22412390_ChIP-Seq_EML_Mouse1.59568925
34FOXA2_19822575_ChIP-Seq_HepG2_Human1.57814261
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57125617
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54513383
37EGR1_19374776_ChIP-ChIP_THP-1_Human1.52718308
38SPI1_23547873_ChIP-Seq_NB4_Human1.52530823
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.51131890
40MAF_26560356_Chip-Seq_TH2_Human1.49386305
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48872909
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48271887
43GATA1_22383799_ChIP-Seq_G1ME_Mouse1.47997540
44* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.46563668
45BCL6_27268052_Chip-Seq_Bcells_Human1.45712279
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43552933
47NCOR1_26117541_ChIP-Seq_K562_Human1.42561489
48GATA1_22025678_ChIP-Seq_K562_Human1.42259112
49* ELF1_20517297_ChIP-Seq_JURKAT_Human1.42235752
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41067607
51BCOR_27268052_Chip-Seq_Bcells_Human1.38342552
52* HNF4A_19822575_ChIP-Seq_HepG2_Human1.36520599
53SPI1_23127762_ChIP-Seq_K562_Human1.35887772
54MYB_26560356_Chip-Seq_TH2_Human1.35433049
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.35323974
56NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.35266931
57KDM2B_26808549_Chip-Seq_DND41_Human1.33869585
58P68_20966046_ChIP-Seq_HELA_Human1.33573799
59MYB_26560356_Chip-Seq_TH1_Human1.31716973
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30994282
61GATA2_22383799_ChIP-Seq_G1ME_Mouse1.30453589
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.28924229
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28843614
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28326172
65HTT_18923047_ChIP-ChIP_STHdh_Human1.27511647
66SA1_27219007_Chip-Seq_ERYTHROID_Human1.27382289
67* IRF8_21731497_ChIP-ChIP_J774_Mouse1.25472395
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.25200220
69PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25160445
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.23604913
71GATA1_19941826_ChIP-Seq_K562_Human1.23565624
72IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23522587
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.23379032
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22065581
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.20312098
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19504131
77PU.1_20513432_ChIP-Seq_Bcells_Mouse1.19223902
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.19198633
79TP63_17297297_ChIP-ChIP_HaCaT_Human1.15427694
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.13984095
81IRF8_27001747_Chip-Seq_BMDM_Mouse1.11035859
82PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10948440
83PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10596648
84CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10313825
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09715960
86HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.09469335
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09238226
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07910433
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07551557
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06082669
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05902962
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05383359
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04475869
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04053311
95CTCF_26484167_Chip-Seq_Bcells_Mouse1.03762353
96GATA4_25053715_ChIP-Seq_YYC3_Human1.03588873
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03585049
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03184835
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01463253
100SMC4_20622854_ChIP-Seq_HELA_Human1.01410106
101SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00767084
102IRF8_22096565_ChIP-ChIP_GC-B_Human0.99830123
103ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99559035
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.99471925
105ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96911309
106ESR1_21235772_ChIP-Seq_MCF-7_Human0.95692034
107IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.89373026
108STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89136559
109AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84272335
110* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84068669
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81855187
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79030766
113AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78429398
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75491755
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75491755
116CDX2_20551321_ChIP-Seq_CACO-2_Human0.75225731
117RAD21_21589869_ChIP-Seq_MESCs_Mouse0.74771776
118SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73500964
119Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.72131326
120TRIM28_21343339_ChIP-Seq_HEK293_Human0.72041799
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71907684
122LXR_22292898_ChIP-Seq_THP-1_Human0.71703477
123ESR1_15608294_ChIP-ChIP_MCF-7_Human0.70453072
124FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.70394869
125AR_20517297_ChIP-Seq_VCAP_Human0.70089972
126RARA_24833708_ChIP-Seq_LIVER_Mouse0.69805584
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69497303
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68691048
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.67722950
130SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.66382518
131EGR1_19032775_ChIP-ChIP_M12_Human0.65900216
132NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.64659462
133PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64326808
134ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.64269723
135FOXA1_25552417_ChIP-Seq_VCAP_Human0.63047573
136ZNF263_19887448_ChIP-Seq_K562_Human0.62544999
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.62386379
138CEBPB_22108803_ChIP-Seq_LS180_Human0.62269884
139KAP1_22055183_ChIP-Seq_ESCs_Mouse0.61032974
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.60446587
141SOX2_20726797_ChIP-Seq_SW620_Human0.57830997
142CBP_21632823_ChIP-Seq_H3396_Human0.57343898
143GATA6_25053715_ChIP-Seq_YYC3_Human0.55241628
144MYC_19915707_ChIP-ChIP_AK7_Human0.55056749
145FOXO3_23340844_ChIP-Seq_DLD1_Human0.55002827
146SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54830309
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.54374774
148* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.54169410
149PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.53748791
150ESET_19884257_ChIP-Seq_ESCs_Mouse0.51652871
151FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.50251314
152ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.48860703
153ERG_20517297_ChIP-Seq_VCAP_Human0.48726683
154GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.48477905
155GATA1_19941827_ChIP-Seq_MEL_Mouse0.48155466
156ERG_21242973_ChIP-ChIP_JURKAT_Human0.48053906
157* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.47853759
158FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.47788178
159EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.47215155
160P53_21459846_ChIP-Seq_SAOS-2_Human0.47116834
161STAT1_17558387_ChIP-Seq_HELA_Human0.46831039
162BCAT_22108803_ChIP-Seq_LS180_Human0.46652776
163GATA3_24758297_ChIP-Seq_MCF-7_Human0.46097298
164PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46089504
165PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45908321
166TAF2_19829295_ChIP-Seq_ESCs_Human0.45791521
167TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.45619878
168SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.45276486
169GATA2_19941826_ChIP-Seq_K562_Human0.45208950
170PPAR_26484153_Chip-Seq_NCI-H1993_Human0.45063980
171RACK7_27058665_Chip-Seq_MCF-7_Human0.44226483
172ESR1_20079471_ChIP-ChIP_T-47D_Human0.43732133
173STAT3_1855785_ChIP-Seq_MESCs_Mouse0.43211589
174P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.43098750

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.75182884
2MP0005360_urolithiasis7.51865624
3MP0005365_abnormal_bile_salt5.91071865
4MP0005085_abnormal_gallbladder_physiolo5.79324174
5MP0008875_abnormal_xenobiotic_pharmacok5.17159571
6MP0003806_abnormal_nucleotide_metabolis3.67589731
7MP0003252_abnormal_bile_duct3.65537103
8MP0003195_calcinosis3.29487736
9MP0005332_abnormal_amino_acid3.28590930
10MP0010329_abnormal_lipoprotein_level3.26321076
11MP0009840_abnormal_foam_cell2.97666716
12MP0005083_abnormal_biliary_tract2.90018607
13MP0001666_abnormal_nutrient_absorption2.70592559
14MP0004019_abnormal_vitamin_homeostasis2.69873336
15MP0003436_decreased_susceptibility_to2.53206387
16MP0001835_abnormal_antigen_presentation2.47482936
17MP0003191_abnormal_cellular_cholesterol2.22178890
18MP0003303_peritoneal_inflammation2.20118789
19MP0002138_abnormal_hepatobiliary_system2.16869578
20MP0009333_abnormal_splenocyte_physiolog2.11726568
21MP0003763_abnormal_thymus_physiology2.08346729
22MP0002118_abnormal_lipid_homeostasis2.03415237
23MP0002132_abnormal_respiratory_system2.03127893
24MP0000609_abnormal_liver_physiology1.92565674
25MP0005025_abnormal_response_to1.88105357
26MP0005000_abnormal_immune_tolerance1.84657845
27MP0009643_abnormal_urine_homeostasis1.83592465
28MP0010155_abnormal_intestine_physiology1.83573136
29MP0003868_abnormal_feces_composition1.83524256
30MP0000685_abnormal_immune_system1.82925832
31MP0001790_abnormal_immune_system1.82261881
32MP0005387_immune_system_phenotype1.82261881
33MP0001764_abnormal_homeostasis1.81680036
34MP0005319_abnormal_enzyme/_coenzyme1.80856533
35MP0005397_hematopoietic_system_phenotyp1.74731798
36MP0001545_abnormal_hematopoietic_system1.74731798
37MP0001800_abnormal_humoral_immune1.72740802
38MP0009785_altered_susceptibility_to1.68426227
39MP0002419_abnormal_innate_immunity1.67212026
40MP0001873_stomach_inflammation1.66980283
41MP0002148_abnormal_hypersensitivity_rea1.62719233
42MP0005584_abnormal_enzyme/coenzyme_acti1.62323354
43MP0002396_abnormal_hematopoietic_system1.60794722
44MP0004043_abnormal_pH_regulation1.57121630
45MP0002723_abnormal_immune_serum1.56162572
46MP0003186_abnormal_redox_activity1.52219425
47MP0003172_abnormal_lysosome_physiology1.50462765
48MP0004947_skin_inflammation1.49202669
49MP0002420_abnormal_adaptive_immunity1.48533590
50MP0002452_abnormal_antigen_presenting1.48406281
51MP0001819_abnormal_immune_cell1.46779631
52MP0009278_abnormal_bone_marrow1.46132245
53MP0005671_abnormal_response_to1.44049150
54MP0000465_gastrointestinal_hemorrhage1.43359041
55MP0002166_altered_tumor_susceptibility1.41836203
56MP0002398_abnormal_bone_marrow1.37417390
57MP0005636_abnormal_mineral_homeostasis1.35994031
58MP0003011_delayed_dark_adaptation1.34466111
59MP0000858_altered_metastatic_potential1.31687347
60MP0005451_abnormal_body_composition1.31181603
61MP0003866_abnormal_defecation1.30389465
62MP0002405_respiratory_system_inflammati1.29414712
63MP0001756_abnormal_urination1.24883331
64MP0001533_abnormal_skeleton_physiology1.23308605
65MP0000716_abnormal_immune_system1.23150113
66MP0002722_abnormal_immune_system1.15670026
67MP0009697_abnormal_copulation1.15602083
68MP0005670_abnormal_white_adipose1.15400765
69MP0000689_abnormal_spleen_morphology1.14454060
70MP0002429_abnormal_blood_cell1.13607131
71MP0004808_abnormal_hematopoietic_stem1.12744840
72MP0008260_abnormal_autophagy1.11979489
73MP0003183_abnormal_peptide_metabolism1.11931306
74MP0000678_abnormal_parathyroid_gland1.11405641
75MP0006082_CNS_inflammation1.09021916
76MP0005220_abnormal_exocrine_pancreas1.06873320
77MP0002254_reproductive_system_inflammat1.04002776
78MP0002876_abnormal_thyroid_physiology1.03463024
79MP0000598_abnormal_liver_morphology1.03394721
80MP0005375_adipose_tissue_phenotype1.02171244
81MP0009764_decreased_sensitivity_to1.01406242
82MP0005647_abnormal_sex_gland1.00793450
83MP0005084_abnormal_gallbladder_morpholo0.99361066
84MP0000681_abnormal_thyroid_gland0.98716654
85MP0003656_abnormal_erythrocyte_physiolo0.98498910
86MP0001853_heart_inflammation0.97292872
87MP0001851_eye_inflammation0.95210997
88MP0004185_abnormal_adipocyte_glucose0.93449023
89MP0006036_abnormal_mitochondrial_physio0.92938738
90MP0000703_abnormal_thymus_morphology0.91546166
91MP0000490_abnormal_crypts_of0.91181424
92MP0002136_abnormal_kidney_physiology0.90760021
93MP0000604_amyloidosis0.90479449
94MP0002933_joint_inflammation0.90029025
95MP0003705_abnormal_hypodermis_morpholog0.89821280
96MP0009642_abnormal_blood_homeostasis0.89406551
97MP0005535_abnormal_body_temperature0.89394114
98MP0005075_abnormal_melanosome_morpholog0.88730069
99MP0002877_abnormal_melanocyte_morpholog0.88067148
100MP0002078_abnormal_glucose_homeostasis0.86787415
101MP0009763_increased_sensitivity_to0.84961682
102MP0005408_hypopigmentation0.84403934
103MP0002006_tumorigenesis0.84225625
104MP0001765_abnormal_ion_homeostasis0.84207156
105MP0008469_abnormal_protein_level0.83054090
106MP0001663_abnormal_digestive_system0.82111091
107MP0001881_abnormal_mammary_gland0.81714835
108MP0008438_abnormal_cutaneous_collagen0.80943045
109MP0010368_abnormal_lymphatic_system0.80742590
110MP0002998_abnormal_bone_remodeling0.80010502
111MP0000249_abnormal_blood_vessel0.79644835
112MP0005376_homeostasis/metabolism_phenot0.74059911
113MP0001661_extended_life_span0.71685580
114MP0005058_abnormal_lysosome_morphology0.71213280
115MP0002971_abnormal_brown_adipose0.70718515
116MP0009765_abnormal_xenobiotic_induced0.68881666
117MP0005334_abnormal_fat_pad0.66991676
118MP0004782_abnormal_surfactant_physiolog0.65828487
119MP0002928_abnormal_bile_duct0.65210192
120MP0003690_abnormal_glial_cell0.65011130
121MP0003329_amyloid_beta_deposits0.62883394
122MP0003638_abnormal_response/metabolism_0.61813497
123MP0000230_abnormal_systemic_arterial0.57658381
124MP0004130_abnormal_muscle_cell0.57584399
125MP0002090_abnormal_vision0.57286686
126MP0005266_abnormal_metabolism0.55709226
127MP0000538_abnormal_urinary_bladder0.53345328
128MP0003953_abnormal_hormone_level0.52842617
129MP0006035_abnormal_mitochondrial_morpho0.52688131
130MP0003724_increased_susceptibility_to0.50830337
131MP0005666_abnormal_adipose_tissue0.50808170
132MP0002168_other_aberrant_phenotype0.49982396
133MP0005448_abnormal_energy_balance0.49768421
134MP0004264_abnormal_extraembryonic_tissu0.49724173
135MP0000639_abnormal_adrenal_gland0.49008366
136MP0008872_abnormal_physiological_respon0.48391654
137MP0002796_impaired_skin_barrier0.47879539
138MP0005395_other_phenotype0.47764227
139MP0008961_abnormal_basal_metabolism0.46365180
140MP0005464_abnormal_platelet_physiology0.43004923
141MP0003075_altered_response_to0.42663119
142MP0005551_abnormal_eye_electrophysiolog0.41860598
143MP0009384_cardiac_valve_regurgitation0.39853281
144MP0002135_abnormal_kidney_morphology0.39835924
145MP0003959_abnormal_lean_body0.39435249
146MP0001944_abnormal_pancreas_morphology0.38368077
147MP0003300_gastrointestinal_ulcer0.38242576
148MP0005166_decreased_susceptibility_to0.37446758
149MP0009115_abnormal_fat_cell0.36762944
150MP0008874_decreased_physiological_sensi0.35374107
151MP0008873_increased_physiological_sensi0.34628806
152MP0002837_dystrophic_cardiac_calcinosis0.34422185
153MP0009053_abnormal_anal_canal0.33511464
154MP0005595_abnormal_vascular_smooth0.31545983
155MP0010234_abnormal_vibrissa_follicle0.30481449
156MP0009672_abnormal_birth_weight0.29841887
157MP0002970_abnormal_white_adipose0.28608195
158MP0000566_synostosis0.28607636
159MP0002822_catalepsy0.28243821
160MP0001845_abnormal_inflammatory_respons0.28151965

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.99831914
2Intrahepatic cholestasis (HP:0001406)6.31972116
3Deep venous thrombosis (HP:0002625)5.95197212
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.82996278
5Xanthomatosis (HP:0000991)5.66576905
6Prolonged partial thromboplastin time (HP:0003645)5.34463946
7Hypobetalipoproteinemia (HP:0003563)5.08611192
8Hyperglycinuria (HP:0003108)4.81847275
9Hyperlipoproteinemia (HP:0010980)4.78912155
10Abnormality of glutamine family amino acid metabolism (HP:0010902)4.70961835
11Ketosis (HP:0001946)4.66259776
12Hyperammonemia (HP:0001987)4.56618491
13Abnormality of serine family amino acid metabolism (HP:0010894)4.46589603
14Abnormality of glycine metabolism (HP:0010895)4.46589603
15Hyperglycinemia (HP:0002154)4.44452498
16Complement deficiency (HP:0004431)4.22109833
17Abnormality of aspartate family amino acid metabolism (HP:0010899)4.17469160
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.15326964
19Joint hemorrhage (HP:0005261)4.08654501
20Gout (HP:0001997)3.97623608
21Hypolipoproteinemia (HP:0010981)3.97228519
22Hypoglycemic coma (HP:0001325)3.93646887
23Ketoacidosis (HP:0001993)3.88376574
24Epidermoid cyst (HP:0200040)3.78763573
25Fat malabsorption (HP:0002630)3.78352740
26Abnormality of fatty-acid metabolism (HP:0004359)3.78097920
27Abnormality of methionine metabolism (HP:0010901)3.71245454
28Abnormality of the common coagulation pathway (HP:0010990)3.65988414
29Hypoalphalipoproteinemia (HP:0003233)3.64456865
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.61901882
31Abnormality of purine metabolism (HP:0004352)3.50907910
32Purpura (HP:0000979)3.48733835
33Petechiae (HP:0000967)3.43997668
34Abnormality of the intrinsic pathway (HP:0010989)3.37056013
35Abnormality of nucleobase metabolism (HP:0010932)3.36456356
36Delayed CNS myelination (HP:0002188)3.35179137
37Conjugated hyperbilirubinemia (HP:0002908)3.32236897
38Prolonged bleeding time (HP:0003010)3.29411821
39Eczematoid dermatitis (HP:0000976)3.24999958
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23252146
41Metabolic acidosis (HP:0001942)3.08831619
42Abnormality of pyrimidine metabolism (HP:0004353)3.07553249
43Hyperbilirubinemia (HP:0002904)3.06043427
44Abnormality of serum amino acid levels (HP:0003112)3.01463001
45Abnormality of complement system (HP:0005339)3.00600968
46Elevated erythrocyte sedimentation rate (HP:0003565)2.99618993
47Generalized aminoaciduria (HP:0002909)2.98916620
48Hypercholesterolemia (HP:0003124)2.98428475
49Dicarboxylic aciduria (HP:0003215)2.97582258
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97582258
51Steatorrhea (HP:0002570)2.96350241
52Epistaxis (HP:0000421)2.86572313
53Alkalosis (HP:0001948)2.83170854
54Vascular calcification (HP:0004934)2.82018511
55Proximal tubulopathy (HP:0000114)2.81908413
56Lethargy (HP:0001254)2.78939941
57Vertebral compression fractures (HP:0002953)2.78364110
58Hyperuricemia (HP:0002149)2.75814419
59Increased purine levels (HP:0004368)2.75814419
60Obstructive lung disease (HP:0006536)2.74656422
61Chronic obstructive pulmonary disease (HP:0006510)2.74656422
62Gingival bleeding (HP:0000225)2.70977613
63Hepatocellular carcinoma (HP:0001402)2.69249130
64Recurrent abscess formation (HP:0002722)2.66307565
65Colitis (HP:0002583)2.65143291
66Dysostosis multiplex (HP:0000943)2.61318042
67Polycythemia (HP:0001901)2.60616056
68Abnormality of macrophages (HP:0004311)2.58589577
69Gastrointestinal inflammation (HP:0004386)2.57382916
70Myositis (HP:0100614)2.56121682
71Recurrent gram-negative bacterial infections (HP:0005420)2.56077199
72Hemorrhage of the eye (HP:0011885)2.52454799
73Hypoglycemic seizures (HP:0002173)2.51978053
74Increased IgE level (HP:0003212)2.50235624
75Myocardial infarction (HP:0001658)2.49642472
76Cardiovascular calcification (HP:0011915)2.48082922
77Abnormality of proline metabolism (HP:0010907)2.47468637
78Hydroxyprolinuria (HP:0003080)2.47468637
79Gastrointestinal stroma tumor (HP:0100723)2.46788189
80Irritability (HP:0000737)2.45045697
81Inflammation of the large intestine (HP:0002037)2.44127312
82Vomiting (HP:0002013)2.43044175
83Meningitis (HP:0001287)2.42620667
84Abnormal platelet function (HP:0011869)2.41312127
85Impaired platelet aggregation (HP:0003540)2.41312127
86Hypertensive crisis (HP:0100735)2.41032687
87Cerebral edema (HP:0002181)2.40660102
88Late onset (HP:0003584)2.40272883
89Agammaglobulinemia (HP:0004432)2.38516158
90Increased serum ferritin (HP:0003281)2.36520832
91Skin nodule (HP:0200036)2.36485110
92Enlarged kidneys (HP:0000105)2.36165267
93Neonatal onset (HP:0003623)2.35725052
94Hypertriglyceridemia (HP:0002155)2.34341095
95Malnutrition (HP:0004395)2.33143487
96Cellulitis (HP:0100658)2.32663889
97Glycosuria (HP:0003076)2.32640802
98Abnormality of urine glucose concentration (HP:0011016)2.32640802
99Systemic lupus erythematosus (HP:0002725)2.31384904
100Sensorimotor neuropathy (HP:0007141)2.29504253
101Recurrent bacterial skin infections (HP:0005406)2.26162845
102Urinary glycosaminoglycan excretion (HP:0003541)2.25307841
103Mucopolysacchariduria (HP:0008155)2.25307841
104Pancreatitis (HP:0001733)2.25128361
105Rickets (HP:0002748)2.22938470
106Spastic diplegia (HP:0001264)2.22654374
107Abnormal delayed hypersensitivity skin test (HP:0002963)2.19710880
108Abnormality of polysaccharide metabolism (HP:0011012)2.19346617
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19346617
110Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19346617
111Abnormality of iron homeostasis (HP:0011031)2.18306240
112Mitral stenosis (HP:0001718)2.17266345
113Panhypogammaglobulinemia (HP:0003139)2.17015172
114Spontaneous abortion (HP:0005268)2.16256295
115Seborrheic dermatitis (HP:0001051)2.14783059
116Hyperactive renin-angiotensin system (HP:0000841)2.12635630
117Recurrent viral infections (HP:0004429)2.10763151
118Abnormal gallbladder morphology (HP:0012437)2.08103969
119Opisthotonus (HP:0002179)2.07747993
120Cholecystitis (HP:0001082)2.05641661
121Abnormal gallbladder physiology (HP:0012438)2.05641661
122Hypokalemic alkalosis (HP:0001949)2.04984331
123Abnormal platelet volume (HP:0011876)2.03515988
124Abnormality of glycolipid metabolism (HP:0010969)2.03510326
125Abnormality of liposaccharide metabolism (HP:0010968)2.03510326
126Abnormality of glycosphingolipid metabolism (HP:0004343)2.03510326
127Urticaria (HP:0001025)2.03073861
128Polygenic inheritance (HP:0010982)2.01655148
129Vasculitis (HP:0002633)2.01619326
130Hyperinsulinemic hypoglycemia (HP:0000825)2.01451150
131Abnormal enzyme/coenzyme activity (HP:0012379)2.00136690
132Brushfield spots (HP:0001088)1.99920821
133Cholelithiasis (HP:0001081)1.98731723
134Recurrent fungal infections (HP:0002841)1.96636349
135Esophageal varix (HP:0002040)1.96512597
136Chronic diarrhea (HP:0002028)1.96391592
137Spontaneous hematomas (HP:0007420)1.96264737
138Nephrolithiasis (HP:0000787)1.93758778
139Amyloidosis (HP:0011034)1.93045472
140Mediastinal lymphadenopathy (HP:0100721)1.92462259
141Growth hormone excess (HP:0000845)1.92383989
142Hepatosplenomegaly (HP:0001433)1.91793651
143Pustule (HP:0200039)1.91770465
144Ileus (HP:0002595)1.91510772
145Abnormality of T cell physiology (HP:0011840)1.90618595
146Hypochromic microcytic anemia (HP:0004840)1.89719562
147Emphysema (HP:0002097)1.89230827
148Fatigue (HP:0012378)1.88394227
149Thrombocytosis (HP:0001894)1.87832423
150Glomerulonephritis (HP:0000099)1.87650314
151Orchitis (HP:0100796)1.86778440
152Joint swelling (HP:0001386)1.86426003
153Renal cortical cysts (HP:0000803)1.86395853
154Abnormality of the nasal mucosa (HP:0000433)1.86122500
155Symptomatic seizures (HP:0011145)1.86082330
156Menorrhagia (HP:0000132)1.85536018
157Abnormality of vitamin metabolism (HP:0100508)1.84514536
158Rhabdomyolysis (HP:0003201)1.84095986
159Nasal polyposis (HP:0100582)1.80834522
160Hypophosphatemic rickets (HP:0004912)1.80791962
161Increased circulating renin level (HP:0000848)1.80360343
162Acanthocytosis (HP:0001927)1.79572511
163Protrusio acetabuli (HP:0003179)1.79048379
164Gingivitis (HP:0000230)1.78978423
165Confusion (HP:0001289)1.78545971
166Abnormality of alkaline phosphatase activity (HP:0004379)1.77919162
167Elevated hepatic transaminases (HP:0002910)1.76652924
168Loss of speech (HP:0002371)1.76606426
169Gastrointestinal dysmotility (HP:0002579)1.75858924
170Recurrent skin infections (HP:0001581)1.75726686
171Increased mean platelet volume (HP:0011877)1.75438761
172Granulocytopenia (HP:0001913)1.75213259
173Skin rash (HP:0000988)1.75192245
174Hypergammaglobulinemia (HP:0010702)1.75132646
175Gastrointestinal infarctions (HP:0005244)1.74272474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.86467422
2ERN14.32584219
3FGFR43.66624411
4SIK13.65567788
5INSRR3.44098758
6MAP4K13.19001971
7WNK33.05232975
8NME22.85078143
9RIPK42.72677665
10WNK42.66542332
11PRPF4B2.61731525
12TAOK32.53211035
13FRK2.26657107
14SMG12.23930859
15OXSR12.21896076
16MST1R2.11797461
17ERBB41.99211313
18ZAP701.89673297
19MAPK151.72198446
20FLT31.64487256
21SCYL21.62767707
22PIK3CG1.60715974
23JAK31.58136877
24TESK21.57928201
25TRIB31.54117996
26TESK11.49127169
27PINK11.48695305
28BTK1.48136745
29STK38L1.43983696
30MAP2K41.41543809
31KIT1.38605419
32PTK61.37136692
33MAPK111.36971429
34EEF2K1.35538433
35PKN21.34560439
36RIPK11.33219117
37TNK21.26536198
38IRAK41.25112911
39MAP3K71.15223159
40TYK21.15056367
41SYK1.11513798
42CSF1R1.11422103
43MAP3K31.10449363
44EPHA21.09602733
45MAPKAPK31.07497024
46PRKAA21.06271550
47LATS11.06090524
48SGK2231.05117766
49SGK4941.05117766
50MAP2K31.04886967
51NEK91.04747388
52DAPK21.04269611
53ICK1.02969459
54JAK21.01496382
55HIPK21.01296460
56FES1.00296012
57IRAK30.99435060
58PIM20.98753080
59LRRK20.98417687
60ABL20.97919020
61BLK0.97821224
62EPHA30.97126695
63TIE10.96958763
64VRK20.95754197
65SGK30.94672352
66BMPR20.92988960
67FGFR20.91395162
68SGK20.90879362
69MAP3K140.89733730
70EPHB10.89216890
71HCK0.88350873
72CDK120.87790542
73SIK30.85896680
74PDK30.83850304
75PDK40.83850304
76IKBKB0.82195170
77MET0.81901218
78GRK60.81844730
79PRKAA10.77613792
80LCK0.77508753
81ERBB20.77440844
82TXK0.77247107
83MAP3K60.76914813
84TAOK20.74888748
85DYRK1B0.74630524
86TBK10.74566282
87KDR0.74308764
88PRKD20.73424253
89STK390.73359728
90MAP2K60.72573116
91PRKCZ0.71089354
92GSK3A0.71055255
93ITK0.71034662
94LYN0.70979258
95JAK10.69182589
96RPS6KB20.68891673
97PTK20.67743558
98MAP3K110.67073016
99PRKG20.67040371
100MAPK120.66549683
101BMX0.65412267
102TEC0.65301116
103PRKACG0.64417333
104MAPK40.63780673
105GRK10.63426267
106MAP3K20.63129942
107CDK40.62638458
108TRPM70.60686950
109MATK0.60454107
110CDK190.59416921
111ARAF0.59177063
112TGFBR20.58753978
113PAK40.58686500
114CAMK2G0.57376030
115MAP3K130.56019723
116IRAK10.55321052
117MAP2K20.55268646
118TAOK10.54894312
119CDC42BPA0.54616351
120PDPK10.51544966
121STK380.51514187
122IRAK20.50420595
123ILK0.49764311
124NEK10.49679837
125MAP3K80.49155334
126MYLK0.49131074
127DAPK10.48421500
128CAMK1D0.47588734
129MAPKAPK20.47117969
130STK100.46671298
131MAP2K10.46542846
132KSR20.46035975
133FER0.44456179
134MARK30.43327153
135LMTK20.42815829
136EPHA40.42033676
137FGFR30.41555583
138PAK30.40945836
139PDK20.40807098
140CSK0.40618801
141IKBKE0.40539466
142MAP3K10.37280614
143IGF1R0.36212837
144MAPK70.35538178
145CDK60.33198593
146PRKCA0.32749231
147PRKCQ0.28308783
148AKT30.26425843
149CSNK1G10.26399930
150PRKCG0.25602032
151PRKACA0.23773190
152PDK10.22089226
153CAMK40.21262054
154RET0.20865280
155MTOR0.16296934
156PBK0.15490170
157MAP3K50.15337035

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.95869502
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.43661337
3Nitrogen metabolism_Homo sapiens_hsa009103.07330425
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.02987445
5Arginine biosynthesis_Homo sapiens_hsa002202.72869603
6Tryptophan metabolism_Homo sapiens_hsa003802.68185889
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.66013786
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.64474274
9Fatty acid degradation_Homo sapiens_hsa000712.58911757
10Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.50066044
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47249710
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.43674835
13Butanoate metabolism_Homo sapiens_hsa006502.39779881
14Allograft rejection_Homo sapiens_hsa053302.28732454
15Peroxisome_Homo sapiens_hsa041462.21821147
16Complement and coagulation cascades_Homo sapiens_hsa046102.21072579
17Propanoate metabolism_Homo sapiens_hsa006402.20493893
18Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.16795861
19Autoimmune thyroid disease_Homo sapiens_hsa053202.12495609
20Graft-versus-host disease_Homo sapiens_hsa053321.99154053
21Chemical carcinogenesis_Homo sapiens_hsa052041.94007576
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.92486492
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90077842
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.88148434
25Histidine metabolism_Homo sapiens_hsa003401.87885961
26Fatty acid metabolism_Homo sapiens_hsa012121.87387988
27Asthma_Homo sapiens_hsa053101.82799795
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.82131098
29PPAR signaling pathway_Homo sapiens_hsa033201.81709598
30beta-Alanine metabolism_Homo sapiens_hsa004101.81464499
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81214745
32Leishmaniasis_Homo sapiens_hsa051401.70485161
33Sulfur metabolism_Homo sapiens_hsa009201.69608117
34Primary immunodeficiency_Homo sapiens_hsa053401.68692373
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.60983930
36Type I diabetes mellitus_Homo sapiens_hsa049401.59435138
37Retinol metabolism_Homo sapiens_hsa008301.58022413
38Bile secretion_Homo sapiens_hsa049761.56069442
39Pyruvate metabolism_Homo sapiens_hsa006201.56064590
40Caffeine metabolism_Homo sapiens_hsa002321.55826290
41Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55558403
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53148099
43Phenylalanine metabolism_Homo sapiens_hsa003601.51421614
44Selenocompound metabolism_Homo sapiens_hsa004501.48297830
45Cyanoamino acid metabolism_Homo sapiens_hsa004601.42466353
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36777866
47Acute myeloid leukemia_Homo sapiens_hsa052211.36516479
48Antigen processing and presentation_Homo sapiens_hsa046121.35103606
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34695493
50Starch and sucrose metabolism_Homo sapiens_hsa005001.34564830
51Folate biosynthesis_Homo sapiens_hsa007901.33282931
52Tyrosine metabolism_Homo sapiens_hsa003501.32918307
53B cell receptor signaling pathway_Homo sapiens_hsa046621.32843497
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31644861
55Maturity onset diabetes of the young_Homo sapiens_hsa049501.28958346
56Fatty acid elongation_Homo sapiens_hsa000621.28304225
57Staphylococcus aureus infection_Homo sapiens_hsa051501.27511927
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26675060
59Cysteine and methionine metabolism_Homo sapiens_hsa002701.25477471
60Carbon metabolism_Homo sapiens_hsa012001.23592634
61Biosynthesis of amino acids_Homo sapiens_hsa012301.22311901
62Hematopoietic cell lineage_Homo sapiens_hsa046401.16838569
63ABC transporters_Homo sapiens_hsa020101.14081865
64Arginine and proline metabolism_Homo sapiens_hsa003301.09911552
65Vitamin digestion and absorption_Homo sapiens_hsa049771.08687645
66Fat digestion and absorption_Homo sapiens_hsa049751.07533736
67Sulfur relay system_Homo sapiens_hsa041221.05429819
68Osteoclast differentiation_Homo sapiens_hsa043801.04466699
69Viral myocarditis_Homo sapiens_hsa054161.04420461
70Steroid biosynthesis_Homo sapiens_hsa001001.03193261
71Herpes simplex infection_Homo sapiens_hsa051680.98776711
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.94892292
73Glutathione metabolism_Homo sapiens_hsa004800.93852867
74Influenza A_Homo sapiens_hsa051640.91587949
75Pertussis_Homo sapiens_hsa051330.91113396
76Toxoplasmosis_Homo sapiens_hsa051450.90173298
77Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.89048998
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88344611
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88038317
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88025186
81Lysine degradation_Homo sapiens_hsa003100.87412066
82Tuberculosis_Homo sapiens_hsa051520.84359153
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79174223
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78315452
85Glycerolipid metabolism_Homo sapiens_hsa005610.78034842
86Measles_Homo sapiens_hsa051620.72238678
87Platelet activation_Homo sapiens_hsa046110.68466233
88Malaria_Homo sapiens_hsa051440.65017542
89Pentose phosphate pathway_Homo sapiens_hsa000300.64822137
90Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60464859
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59398499
92Chronic myeloid leukemia_Homo sapiens_hsa052200.59100919
93Vitamin B6 metabolism_Homo sapiens_hsa007500.58071566
94African trypanosomiasis_Homo sapiens_hsa051430.56029204
95T cell receptor signaling pathway_Homo sapiens_hsa046600.55418525
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55225408
97Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.53736262
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53595791
99Pancreatic cancer_Homo sapiens_hsa052120.52716749
100Fructose and mannose metabolism_Homo sapiens_hsa000510.52385710
101Metabolic pathways_Homo sapiens_hsa011000.51777259
102Ribosome_Homo sapiens_hsa030100.51098580
103Non-small cell lung cancer_Homo sapiens_hsa052230.50825998
104Rheumatoid arthritis_Homo sapiens_hsa053230.50812831
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.50347322
106N-Glycan biosynthesis_Homo sapiens_hsa005100.48521062
107One carbon pool by folate_Homo sapiens_hsa006700.46987004
108Systemic lupus erythematosus_Homo sapiens_hsa053220.46948660
109Fatty acid biosynthesis_Homo sapiens_hsa000610.46293612
110TNF signaling pathway_Homo sapiens_hsa046680.46155323
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.43423997
112Galactose metabolism_Homo sapiens_hsa000520.42062586
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41258187
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.29698495
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28412119
116Insulin resistance_Homo sapiens_hsa049310.23480085
117Linoleic acid metabolism_Homo sapiens_hsa005910.21295715
118Prion diseases_Homo sapiens_hsa050200.21229819
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.20661771
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.12314196
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11927838
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.08746910
123Glucagon signaling pathway_Homo sapiens_hsa049220.07540779
124Mineral absorption_Homo sapiens_hsa049780.06033327
125Protein digestion and absorption_Homo sapiens_hsa049740.05000396
126Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01889456
127Other glycan degradation_Homo sapiens_hsa005110.00905165
128Carbohydrate digestion and absorption_Homo sapiens_hsa049730.00851713
129Arachidonic acid metabolism_Homo sapiens_hsa005900.00100936
130Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1651169
131Collecting duct acid secretion_Homo sapiens_hsa04966-0.1561865
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.1529050
133Hepatitis C_Homo sapiens_hsa05160-0.1524162
134Insulin signaling pathway_Homo sapiens_hsa04910-0.1398596
135Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1110499
136Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0954010
137Regulation of autophagy_Homo sapiens_hsa04140-0.0670794
138Circadian rhythm_Homo sapiens_hsa04710-0.0483183
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0349931
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0197657
141Lysosome_Homo sapiens_hsa04142-0.0172487
142Renin-angiotensin system_Homo sapiens_hsa04614-0.0169904
143Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0112300
144AMPK signaling pathway_Homo sapiens_hsa04152-0.0064082

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