ABHD15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)7.04786100
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.04786100
3L-phenylalanine metabolic process (GO:0006558)6.64605391
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64605391
5aromatic amino acid family catabolic process (GO:0009074)5.92320960
6alpha-linolenic acid metabolic process (GO:0036109)5.68990486
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.30296043
8fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.00860613
9bile acid biosynthetic process (GO:0006699)4.98703040
10indole-containing compound catabolic process (GO:0042436)4.92883980
11indolalkylamine catabolic process (GO:0046218)4.92883980
12tryptophan catabolic process (GO:0006569)4.92883980
13urea cycle (GO:0000050)4.89515269
14urea metabolic process (GO:0019627)4.89515269
15sulfur amino acid catabolic process (GO:0000098)4.84180118
16tryptophan metabolic process (GO:0006568)4.79487028
17complement activation, alternative pathway (GO:0006957)4.73618042
18glyoxylate metabolic process (GO:0046487)4.72996711
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72758908
20negative regulation of cell killing (GO:0031342)4.72758908
21kynurenine metabolic process (GO:0070189)4.69247297
22peptidyl-glutamic acid carboxylation (GO:0017187)4.58221707
23protein carboxylation (GO:0018214)4.58221707
24acylglycerol homeostasis (GO:0055090)4.53546633
25triglyceride homeostasis (GO:0070328)4.53546633
26nitrogen cycle metabolic process (GO:0071941)4.52861029
27bile acid metabolic process (GO:0008206)4.48201834
28tyrosine metabolic process (GO:0006570)4.42529088
29negative regulation of fibrinolysis (GO:0051918)4.38742781
30high-density lipoprotein particle remodeling (GO:0034375)4.37730321
31regulation of triglyceride catabolic process (GO:0010896)4.32886374
32regulation of protein activation cascade (GO:2000257)4.28732430
33aromatic amino acid family metabolic process (GO:0009072)4.28466230
34cellular response to interleukin-15 (GO:0071350)4.27954571
35regulation of fibrinolysis (GO:0051917)4.26619043
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25967940
37cysteine metabolic process (GO:0006534)4.25528850
38antigen processing and presentation of endogenous antigen (GO:0019883)4.19730569
39antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10458733
40amino-acid betaine metabolic process (GO:0006577)4.07090388
41regulation of complement activation (GO:0030449)4.01311935
42plasma lipoprotein particle clearance (GO:0034381)3.97917316
43valine metabolic process (GO:0006573)3.93257661
44regulation of cholesterol esterification (GO:0010872)3.91967285
45bile acid and bile salt transport (GO:0015721)3.91939928
46lysine metabolic process (GO:0006553)3.91625424
47lysine catabolic process (GO:0006554)3.91625424
48phospholipid efflux (GO:0033700)3.90937205
49reverse cholesterol transport (GO:0043691)3.90644933
50serine family amino acid catabolic process (GO:0009071)3.88772492
51coenzyme catabolic process (GO:0009109)3.88653282
52plasma lipoprotein particle remodeling (GO:0034369)3.85291209
53protein-lipid complex remodeling (GO:0034368)3.85291209
54macromolecular complex remodeling (GO:0034367)3.85291209
55alpha-amino acid catabolic process (GO:1901606)3.85174849
56fatty acid beta-oxidation (GO:0006635)3.84599378
57fatty acid oxidation (GO:0019395)3.80972756
58negative regulation of sterol transport (GO:0032372)3.80347015
59negative regulation of cholesterol transport (GO:0032375)3.80347015
60homocysteine metabolic process (GO:0050667)3.79414273
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.72844595
62response to interleukin-15 (GO:0070672)3.72811445
63lipid oxidation (GO:0034440)3.72146785
64indolalkylamine metabolic process (GO:0006586)3.66549940
65fatty acid catabolic process (GO:0009062)3.66541358
66cellular amino acid catabolic process (GO:0009063)3.62222125
67cellular ketone body metabolic process (GO:0046950)3.60439872
68imidazole-containing compound metabolic process (GO:0052803)3.55019471
69monocarboxylic acid catabolic process (GO:0072329)3.54806577
70fatty acid homeostasis (GO:0055089)3.49883341
71regulation of cholesterol homeostasis (GO:2000188)3.46255027
72positive regulation of fatty acid beta-oxidation (GO:0032000)3.46201303
73positive regulation of lipid catabolic process (GO:0050996)3.45007662
74cholesterol efflux (GO:0033344)3.44170293
75carboxylic acid catabolic process (GO:0046395)3.44134991
76organic acid catabolic process (GO:0016054)3.44134991
772-oxoglutarate metabolic process (GO:0006103)3.43780115
78plasma lipoprotein particle assembly (GO:0034377)3.42218781
79cellular modified amino acid catabolic process (GO:0042219)3.41543754
80negative regulation of lipase activity (GO:0060192)3.35982540
81phospholipid homeostasis (GO:0055091)3.35199642
82short-chain fatty acid metabolic process (GO:0046459)3.31604574
83cellular biogenic amine catabolic process (GO:0042402)3.30064033
84amine catabolic process (GO:0009310)3.30064033
85regulation of T cell mediated cytotoxicity (GO:0001914)3.29834470
86positive regulation of lipoprotein lipase activity (GO:0051006)3.28779480
87positive regulation of triglyceride lipase activity (GO:0061365)3.28779480
88positive regulation of fatty acid biosynthetic process (GO:0045723)3.27413092
89regulation of cholesterol metabolic process (GO:0090181)3.26762266
90acetyl-CoA metabolic process (GO:0006084)3.26054844
91cholesterol homeostasis (GO:0042632)3.25141717
92glycine metabolic process (GO:0006544)3.23837804
93positive regulation of glycolytic process (GO:0045821)3.23325263
94benzene-containing compound metabolic process (GO:0042537)3.23064126
95positive regulation of gamma-delta T cell activation (GO:0046645)3.23050603
96cytolysis (GO:0019835)3.22861525
97ethanol oxidation (GO:0006069)3.22048976
98regulation of cholesterol biosynthetic process (GO:0045540)3.20994851
99COPI coating of Golgi vesicle (GO:0048205)3.20259591
100Golgi transport vesicle coating (GO:0048200)3.20259591
101regulation of gamma-delta T cell differentiation (GO:0045586)3.20259435
102neutrophil activation involved in immune response (GO:0002283)3.19268995
103carnitine metabolic process (GO:0009437)3.19238628
104lipoprotein metabolic process (GO:0042157)3.19089718
105glutamate metabolic process (GO:0006536)3.18517269
106tricarboxylic acid metabolic process (GO:0072350)3.18491026
107complement activation, classical pathway (GO:0006958)3.18445079
108sterol homeostasis (GO:0055092)3.18373635
109complement activation (GO:0006956)3.18006204
110positive regulation of triglyceride metabolic process (GO:0090208)3.17857426
111low-density lipoprotein particle remodeling (GO:0034374)3.17471900
112positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16867882
113regulation of gamma-delta T cell activation (GO:0046643)3.16624101
114negative regulation of execution phase of apoptosis (GO:1900118)3.15865053
115cofactor catabolic process (GO:0051187)3.14733581
116exogenous drug catabolic process (GO:0042738)3.14165114
117drug catabolic process (GO:0042737)3.01387194
118positive regulation of sterol transport (GO:0032373)2.98258347
119positive regulation of cholesterol transport (GO:0032376)2.98258347
120epoxygenase P450 pathway (GO:0019373)2.97299604
121antigen processing and presentation via MHC class Ib (GO:0002475)2.96382619
122positive thymic T cell selection (GO:0045059)2.83306964
123lymph node development (GO:0048535)2.82477015
124low-density lipoprotein particle clearance (GO:0034383)2.81872565
125macroautophagy (GO:0016236)2.78377872
126regulation of memory T cell differentiation (GO:0043380)2.76427043
127negative regulation of lymphocyte mediated immunity (GO:0002707)2.75173391
128neutrophil activation (GO:0042119)2.73663103
129regulation of extracellular matrix disassembly (GO:0010715)2.72283075
130negative T cell selection (GO:0043383)2.71697881
131regulation of lipoprotein particle clearance (GO:0010984)2.68385183
132regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.67859020
133regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.66630973
134immunoglobulin mediated immune response (GO:0016064)2.65226540
135negative regulation of T cell mediated immunity (GO:0002710)2.61952445
136regulation of leukocyte mediated cytotoxicity (GO:0001910)2.61866428
137negative regulation of phagocytosis (GO:0050765)2.61800952
138negative thymic T cell selection (GO:0045060)2.59391266
139negative regulation of granulocyte differentiation (GO:0030853)2.56757420
140ketone body metabolic process (GO:1902224)2.55502122
141negative regulation of glycoprotein biosynthetic process (GO:0010561)2.52548500
142negative regulation of leukocyte mediated immunity (GO:0002704)2.52181803
143negative regulation of innate immune response (GO:0045824)2.49888655
144positive regulation of cholesterol efflux (GO:0010875)2.49595277
145positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.47534003
146peptide hormone processing (GO:0016486)2.46712070
147interferon-gamma production (GO:0032609)2.44545196
148retinol metabolic process (GO:0042572)2.43902928
149ethanol metabolic process (GO:0006067)2.41722877
150regulation of granulocyte differentiation (GO:0030852)2.41220534
151negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.40033576
152zinc ion homeostasis (GO:0055069)2.37460973
153negative regulation of protein autophosphorylation (GO:0031953)2.36149640
154granulocyte activation (GO:0036230)2.35316321
155oligosaccharide catabolic process (GO:0009313)2.35179255
156positive regulation of granulocyte differentiation (GO:0030854)2.34040406
157regulation of triglyceride metabolic process (GO:0090207)2.33790829
158drug metabolic process (GO:0017144)2.32356188
159tolerance induction (GO:0002507)2.31578492
160thymic T cell selection (GO:0045061)2.31444537
161primary alcohol metabolic process (GO:0034308)2.30357651
162diacylglycerol metabolic process (GO:0046339)2.29417586
163positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.29195155
164regulation of cell killing (GO:0031341)2.29044423
165triglyceride catabolic process (GO:0019433)2.26467733
166lipid storage (GO:0019915)2.26334935
167regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.26334180
168regulation of natural killer cell mediated immunity (GO:0002715)2.26334180
169omega-hydroxylase P450 pathway (GO:0097267)2.23683951
170positive T cell selection (GO:0043368)2.23254552
171regulation of cellular extravasation (GO:0002691)2.22998257
172cellular glucuronidation (GO:0052695)2.22643274
173detection of bacterium (GO:0016045)2.22313707
174T cell selection (GO:0045058)2.21455414
175S-adenosylmethionine metabolic process (GO:0046500)2.21409182
176negative regulation of interleukin-6 production (GO:0032715)2.20817632
177water-soluble vitamin biosynthetic process (GO:0042364)2.20775580
178phenylpropanoid metabolic process (GO:0009698)2.20336965
179interleukin-1-mediated signaling pathway (GO:0070498)2.19997773
180regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.19379699
181regulation of sterol transport (GO:0032371)2.17994867

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.92390414
2* RXR_22158963_ChIP-Seq_LIVER_Mouse7.31476343
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.28614540
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.69500295
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.67843175
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.56609900
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.81287866
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.71611769
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.81728945
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.28562801
11GATA1_22025678_ChIP-Seq_K562_Human2.75582030
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.65895704
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.60038231
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56657366
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37799204
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.31947886
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.28856755
18VDR_24763502_ChIP-Seq_THP-1_Human1.96458220
19CLOCK_20551151_ChIP-Seq_293T_Human1.86991977
20TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.83633584
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76745307
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.66963661
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64330155
24RUNX1_22412390_ChIP-Seq_EML_Mouse1.60159788
25MYB_26560356_Chip-Seq_TH2_Human1.58417537
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.55774939
27* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45561847
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45391939
29UTX_26944678_Chip-Seq_JUKART_Human1.44965226
30SPI1_23547873_ChIP-Seq_NB4_Human1.42904172
31SCL_19346495_ChIP-Seq_HPC-7_Human1.39340188
32SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.38965440
33FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38887623
34MAF_26560356_Chip-Seq_TH1_Human1.38880123
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37143994
36STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36933647
37STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35888263
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.35802062
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33803401
40MAF_26560356_Chip-Seq_TH2_Human1.24696896
41BCL6_27268052_Chip-Seq_Bcells_Human1.24116933
42P300_27268052_Chip-Seq_Bcells_Human1.21246989
43* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17557402
44HNF4A_19822575_ChIP-Seq_HepG2_Human1.16311145
45SPI1_23127762_ChIP-Seq_K562_Human1.15642963
46IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12334232
47P68_20966046_ChIP-Seq_HELA_Human1.11051396
48EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10491958
49ELF1_20517297_ChIP-Seq_JURKAT_Human1.08848371
50HTT_18923047_ChIP-ChIP_STHdh_Human1.06899772
51STAT1_20625510_ChIP-Seq_HELA_Human1.06368926
52RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05802084
53SOX2_27498859_Chip-Seq_STOMACH_Mouse1.05012440
54* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03753480
55VDR_24787735_ChIP-Seq_THP-1_Human1.03443197
56P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03301083
57SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02039762
58CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01332777
59SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01244517
60LXR_22292898_ChIP-Seq_THP-1_Human1.00872090
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.00751385
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00172254
63E2F1_20622854_ChIP-Seq_HELA_Human0.99645373
64GATA1_19941826_ChIP-Seq_K562_Human0.99246526
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98871216
66* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98744396
67GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98108558
68RACK7_27058665_Chip-Seq_MCF-7_Human0.97899290
69KDM2B_26808549_Chip-Seq_SUP-B15_Human0.97706885
70MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.96531365
71PHF8_20622854_ChIP-Seq_HELA_Human0.96180638
72* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.95869195
73MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95462922
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95204949
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.94704939
76CTCF_26484167_Chip-Seq_Bcells_Mouse0.94096803
77FOXO3_23340844_ChIP-Seq_DLD1_Human0.92864168
78SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92199646
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91572699
80RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91385396
81CDX2_20551321_ChIP-Seq_CACO-2_Human0.91140662
82ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90603604
83FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90539633
84PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89928053
85ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86674682
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86438977
87Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86137153
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86067808
89BRD4_27068464_Chip-Seq_AML-cells_Mouse0.85903272
90IRF8_27001747_Chip-Seq_BMDM_Mouse0.85014745
91RARB_24833708_ChIP-Seq_LIVER_Mouse0.85007621
92MYB_21317192_ChIP-Seq_ERMYB_Mouse0.82797119
93GATA4_25053715_ChIP-Seq_YYC3_Human0.80890216
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79478069
95AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.79169350
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79113185
97RARA_24833708_ChIP-Seq_LIVER_Mouse0.78479608
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.77567866
99* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77520032
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.77122687
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.76036403
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75572643
103* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.74925258
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.74493449
105RUNX_20019798_ChIP-Seq_JUKART_Human0.73823005
106TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.73491516
107FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.71885778
108* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71494958
109AR_20517297_ChIP-Seq_VCAP_Human0.70642536
110ERG_20517297_ChIP-Seq_VCAP_Human0.70520350
111FOXA1_25552417_ChIP-Seq_VCAP_Human0.69952200
112BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.69778767
113RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69346818
114GATA2_19941826_ChIP-Seq_K562_Human0.69002219
115MYC_22102868_ChIP-Seq_BL_Human0.68509777
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.64815724
117CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.64717090
118* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.64642076
119* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.64557206
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.63767742
121CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.62612582
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.61946128
123* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.61886632
124GATA3_27048872_Chip-Seq_THYMUS_Human0.61359385
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.61262129
126PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.61096752
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.60561695
128* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.58646093
129BCOR_27268052_Chip-Seq_Bcells_Human0.58279006
130GATA3_26560356_Chip-Seq_TH2_Human0.57820829
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.56174817
132VDR_21846776_ChIP-Seq_THP-1_Human0.55871072
133MYB_26560356_Chip-Seq_TH1_Human0.55458585
134SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.55325805
135FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.55218937
136TCF7_22412390_ChIP-Seq_EML_Mouse0.54709447
137* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.54292983
138NFIB_24661679_ChIP-Seq_LUNG_Mouse0.53829708
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.53764505
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.53718393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.10919958
2MP0005365_abnormal_bile_salt5.86366357
3MP0005360_urolithiasis5.84008552
4MP0005085_abnormal_gallbladder_physiolo5.19338530
5MP0008875_abnormal_xenobiotic_pharmacok4.19303428
6MP0003252_abnormal_bile_duct3.65555082
7MP0010329_abnormal_lipoprotein_level3.49995229
8MP0003806_abnormal_nucleotide_metabolis3.03297515
9MP0003195_calcinosis2.95227047
10MP0009840_abnormal_foam_cell2.88313108
11MP0003191_abnormal_cellular_cholesterol2.65840772
12MP0005083_abnormal_biliary_tract2.42555748
13MP0001666_abnormal_nutrient_absorption2.33031931
14MP0000609_abnormal_liver_physiology2.27940324
15MP0002118_abnormal_lipid_homeostasis2.27384543
16MP0005332_abnormal_amino_acid2.26501280
17MP0010234_abnormal_vibrissa_follicle2.21869277
18MP0005670_abnormal_white_adipose2.09448604
19MP0003763_abnormal_thymus_physiology1.93493499
20MP0005220_abnormal_exocrine_pancreas1.84648239
21MP0002138_abnormal_hepatobiliary_system1.84501252
22MP0003868_abnormal_feces_composition1.84225058
23MP0005387_immune_system_phenotype1.80919675
24MP0001790_abnormal_immune_system1.80919675
25MP0005000_abnormal_immune_tolerance1.79020152
26MP0001986_abnormal_taste_sensitivity1.73729348
27MP0005319_abnormal_enzyme/_coenzyme1.73540281
28MP0001800_abnormal_humoral_immune1.73246408
29MP0004019_abnormal_vitamin_homeostasis1.64715304
30MP0001764_abnormal_homeostasis1.59766420
31MP0002723_abnormal_immune_serum1.56747688
32MP0002837_dystrophic_cardiac_calcinosis1.56481798
33MP0002078_abnormal_glucose_homeostasis1.56385947
34MP0009643_abnormal_urine_homeostasis1.56142728
35MP0003724_increased_susceptibility_to1.54474440
36MP0002420_abnormal_adaptive_immunity1.52812890
37MP0002166_altered_tumor_susceptibility1.52368933
38MP0005645_abnormal_hypothalamus_physiol1.51915886
39MP0009333_abnormal_splenocyte_physiolog1.50590941
40MP0001819_abnormal_immune_cell1.50457323
41MP0005584_abnormal_enzyme/coenzyme_acti1.49012084
42MP0009780_abnormal_chondrocyte_physiolo1.48242190
43MP0002452_abnormal_antigen_presenting1.47639921
44MP0002693_abnormal_pancreas_physiology1.45723176
45MP0000013_abnormal_adipose_tissue1.44579706
46MP0010155_abnormal_intestine_physiology1.44414457
47MP0001944_abnormal_pancreas_morphology1.41954803
48MP0001873_stomach_inflammation1.40908449
49MP0002148_abnormal_hypersensitivity_rea1.38816835
50MP0004130_abnormal_muscle_cell1.35441507
51MP0005058_abnormal_lysosome_morphology1.28106653
52MP0002971_abnormal_brown_adipose1.28081887
53MP0002405_respiratory_system_inflammati1.26248433
54MP0003186_abnormal_redox_activity1.26026564
55MP0000598_abnormal_liver_morphology1.22871376
56MP0005666_abnormal_adipose_tissue1.22241667
57MP0002877_abnormal_melanocyte_morpholog1.20753984
58MP0005334_abnormal_fat_pad1.19903294
59MP0008469_abnormal_protein_level1.17052269
60MP0004947_skin_inflammation1.15836256
61MP0002909_abnormal_adrenal_gland1.13005940
62MP0009763_increased_sensitivity_to1.11954383
63MP0002928_abnormal_bile_duct1.11455829
64MP0002876_abnormal_thyroid_physiology1.11344484
65MP0009697_abnormal_copulation1.11302177
66MP0003183_abnormal_peptide_metabolism1.10218543
67MP0000716_abnormal_immune_system1.09781447
68MP0005535_abnormal_body_temperature1.08774844
69MP0009642_abnormal_blood_homeostasis1.07787629
70MP0005464_abnormal_platelet_physiology1.07300774
71MP0000465_gastrointestinal_hemorrhage1.05964801
72MP0001851_eye_inflammation1.05027546
73MP0000015_abnormal_ear_pigmentation1.04552835
74MP0000689_abnormal_spleen_morphology1.04132846
75MP0002006_tumorigenesis1.03949998
76MP0003300_gastrointestinal_ulcer1.02686149
77MP0003436_decreased_susceptibility_to1.02240475
78MP0003283_abnormal_digestive_organ1.02180690
79MP0005636_abnormal_mineral_homeostasis1.00597880
80MP0005448_abnormal_energy_balance1.00186907
81MP0003878_abnormal_ear_physiology0.99990018
82MP0005377_hearing/vestibular/ear_phenot0.99990018
83MP0006036_abnormal_mitochondrial_physio0.99779787
84MP0005375_adipose_tissue_phenotype0.98558667
85MP0002398_abnormal_bone_marrow0.98169826
86MP0002009_preneoplasia0.95850590
87MP0005379_endocrine/exocrine_gland_phen0.95632549
88MP0004043_abnormal_pH_regulation0.93869592
89MP0002722_abnormal_immune_system0.92034747
90MP0002933_joint_inflammation0.91829389
91MP0003879_abnormal_hair_cell0.91665334
92MP0001661_extended_life_span0.90960284
93MP0000003_abnormal_adipose_tissue0.90456446
94MP0003656_abnormal_erythrocyte_physiolo0.89761547
95MP0002970_abnormal_white_adipose0.89242242
96MP0003953_abnormal_hormone_level0.87795189
97MP0001756_abnormal_urination0.87615787
98MP0002998_abnormal_bone_remodeling0.86835520
99MP0002429_abnormal_blood_cell0.85581657
100MP0005084_abnormal_gallbladder_morpholo0.84471889
101MP0002132_abnormal_respiratory_system0.83196558
102MP0009765_abnormal_xenobiotic_induced0.80803524
103MP0009764_decreased_sensitivity_to0.78847073
104MP0000604_amyloidosis0.78255026
105MP0003172_abnormal_lysosome_physiology0.78020752
106MP0000685_abnormal_immune_system0.76283750
107MP0003011_delayed_dark_adaptation0.73482205
108MP0005647_abnormal_sex_gland0.73209755
109MP0003959_abnormal_lean_body0.72721598
110MP0004264_abnormal_extraembryonic_tissu0.72651370
111MP0005451_abnormal_body_composition0.72111646
112MP0002254_reproductive_system_inflammat0.70183225
113MP0001845_abnormal_inflammatory_respons0.70156423
114MP0000639_abnormal_adrenal_gland0.70070939
115MP0005671_abnormal_response_to0.65760834
116MP0005408_hypopigmentation0.64203355
117MP0006082_CNS_inflammation0.61419451
118MP0009115_abnormal_fat_cell0.59977235
119MP0009785_altered_susceptibility_to0.59723027
120MP0005376_homeostasis/metabolism_phenot0.59469434
121MP0004185_abnormal_adipocyte_glucose0.59134789
122MP0001533_abnormal_skeleton_physiology0.58420444
123MP0005075_abnormal_melanosome_morpholog0.57709914
124MP0005025_abnormal_response_to0.57286429
125MP0000371_diluted_coat_color0.57229536
126MP0008961_abnormal_basal_metabolism0.56664757
127MP0002419_abnormal_innate_immunity0.55856497
128MP0005452_abnormal_adipose_tissue0.52261965
129MP0000230_abnormal_systemic_arterial0.50774874
130MP0003866_abnormal_defecation0.50577818
131MP0008873_increased_physiological_sensi0.50573986
132MP0001835_abnormal_antigen_presentation0.50511918
133MP0002136_abnormal_kidney_physiology0.48522013
134MP0005266_abnormal_metabolism0.47769201
135MP0001765_abnormal_ion_homeostasis0.46488450

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.94786480
2Hypoglycemic coma (HP:0001325)5.94905988
3Intrahepatic cholestasis (HP:0001406)5.72814208
4Deep venous thrombosis (HP:0002625)5.44358262
5Xanthomatosis (HP:0000991)5.30914513
6Prolonged partial thromboplastin time (HP:0003645)5.26539260
7Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11978834
8Hypoglycemic seizures (HP:0002173)4.96526384
9Complement deficiency (HP:0004431)4.86047609
10Hypobetalipoproteinemia (HP:0003563)4.78379076
11Ketosis (HP:0001946)4.74767400
12Hyperlipoproteinemia (HP:0010980)4.59297057
13Hyperinsulinemic hypoglycemia (HP:0000825)4.43764995
14Ketoacidosis (HP:0001993)4.19783741
15Abnormality of the common coagulation pathway (HP:0010990)4.09524970
16Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.90249778
17Symptomatic seizures (HP:0011145)3.86367139
18Hyperammonemia (HP:0001987)3.86183036
19Abnormality of the intrinsic pathway (HP:0010989)3.85417700
20Joint hemorrhage (HP:0005261)3.82270553
21Epidermoid cyst (HP:0200040)3.80594380
22Hypolipoproteinemia (HP:0010981)3.67938314
23Orchitis (HP:0100796)3.61793675
24Abnormality of complement system (HP:0005339)3.60576019
25Myositis (HP:0100614)3.60386436
26Conjugated hyperbilirubinemia (HP:0002908)3.57986555
27Hyperglycinemia (HP:0002154)3.54776113
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.48988214
29Abnormality of fatty-acid metabolism (HP:0004359)3.45139001
30Hyperglycinuria (HP:0003108)3.39861263
31Optic neuritis (HP:0100653)3.39595075
32Retrobulbar optic neuritis (HP:0100654)3.39595075
33Abnormality of serine family amino acid metabolism (HP:0010894)3.34714341
34Abnormality of glycine metabolism (HP:0010895)3.34714341
35Late onset (HP:0003584)3.32408928
36Hypoalphalipoproteinemia (HP:0003233)3.31032271
37Generalized aminoaciduria (HP:0002909)3.29723877
38Stomatitis (HP:0010280)3.28311210
39Hypercholesterolemia (HP:0003124)3.27878857
40Fat malabsorption (HP:0002630)3.24945148
41Abnormality of glutamine family amino acid metabolism (HP:0010902)3.20114258
42Hyperglycemia (HP:0003074)3.19338211
43Abnormality of sulfur amino acid metabolism (HP:0004339)3.00788338
44Hyperbilirubinemia (HP:0002904)2.96693666
45Abnormality of methionine metabolism (HP:0010901)2.96088208
46Abnormality of the pancreatic islet cells (HP:0006476)2.91510329
47Abnormality of endocrine pancreas physiology (HP:0012093)2.91510329
48Systemic lupus erythematosus (HP:0002725)2.91238821
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87602641
50Dicarboxylic aciduria (HP:0003215)2.84760450
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84760450
52Skin nodule (HP:0200036)2.78596227
53Increased CSF protein (HP:0002922)2.76147233
54Elevated erythrocyte sedimentation rate (HP:0003565)2.74165042
55Recurrent abscess formation (HP:0002722)2.71914168
56Vacuolated lymphocytes (HP:0001922)2.69684980
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.68040620
58Abnormality of purine metabolism (HP:0004352)2.64401625
59Abnormality of nucleobase metabolism (HP:0010932)2.64377746
60Abnormality of pyrimidine metabolism (HP:0004353)2.64329988
61Eczematoid dermatitis (HP:0000976)2.59409261
62Recurrent fungal infections (HP:0002841)2.55914086
63Abnormality of liposaccharide metabolism (HP:0010968)2.53581799
64Abnormality of glycosphingolipid metabolism (HP:0004343)2.53581799
65Abnormality of glycolipid metabolism (HP:0010969)2.53581799
66Metabolic acidosis (HP:0001942)2.52815042
67Glomerulonephritis (HP:0000099)2.52413235
68Pancreatic islet-cell hyperplasia (HP:0004510)2.52352184
69Insulin resistance (HP:0000855)2.51594368
70Retinal atrophy (HP:0001105)2.50368329
71Brushfield spots (HP:0001088)2.48707864
72Insulin-resistant diabetes mellitus (HP:0000831)2.46319622
73Albinism (HP:0001022)2.45979746
74Delayed CNS myelination (HP:0002188)2.45742681
75Recurrent cutaneous fungal infections (HP:0011370)2.45342241
76Chronic mucocutaneous candidiasis (HP:0002728)2.45342241
77Increased cerebral lipofuscin (HP:0011813)2.44554292
78Irritability (HP:0000737)2.43087753
79Myocardial infarction (HP:0001658)2.42019721
80Abnormality of macrophages (HP:0004311)2.40744849
81Progressive neurologic deterioration (HP:0002344)2.39479515
82Gastrointestinal infarctions (HP:0005244)2.37919169
83Gout (HP:0001997)2.37832248
84Thyroiditis (HP:0100646)2.36425068
85Vascular calcification (HP:0004934)2.35850371
86Pancreatitis (HP:0001733)2.34509474
87Abnormality of serum amino acid levels (HP:0003112)2.32912797
88Vasculitis (HP:0002633)2.32002215
89Meningitis (HP:0001287)2.31474929
90Prolonged bleeding time (HP:0003010)2.30393868
91Recurrent bacterial skin infections (HP:0005406)2.29022023
92Polygenic inheritance (HP:0010982)2.27801253
93Severe combined immunodeficiency (HP:0004430)2.27074999
94Chronic diarrhea (HP:0002028)2.26724771
95Episodic fever (HP:0001954)2.26411704
96Pulmonary infiltrates (HP:0002113)2.26410731
97Hemoptysis (HP:0002105)2.25967906
98Growth hormone excess (HP:0000845)2.21222689
99Steatorrhea (HP:0002570)2.20714967
100Joint swelling (HP:0001386)2.19228595
101Lethargy (HP:0001254)2.19054471
102Pulmonary embolism (HP:0002204)2.17750026
103Cheilitis (HP:0100825)2.17449201
104Mitral stenosis (HP:0001718)2.14217422
105Recurrent skin infections (HP:0001581)2.13365764
106Hemorrhage of the eye (HP:0011885)2.13299396
107Hepatocellular carcinoma (HP:0001402)2.12393899
108Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.12087849
109Cardiovascular calcification (HP:0011915)2.10410030
110Menorrhagia (HP:0000132)2.08119575
111Inflammation of the large intestine (HP:0002037)2.07919231
112Large for gestational age (HP:0001520)2.07548627
113Abnormality of vitamin B metabolism (HP:0004340)2.07504722
114Keratoconjunctivitis (HP:0001096)2.07446106
115Gastrointestinal inflammation (HP:0004386)2.07285445
116Mucopolysacchariduria (HP:0008155)2.06911363
117Urinary glycosaminoglycan excretion (HP:0003541)2.06911363
118Recurrent gram-negative bacterial infections (HP:0005420)2.06751158
119Limb hypertonia (HP:0002509)2.05574889
120Stridor (HP:0010307)2.05419954
121Abnormality of vitamin metabolism (HP:0100508)2.05208135
122Hematochezia (HP:0002573)2.04949054
123Gingival bleeding (HP:0000225)2.04565103
124Spontaneous abortion (HP:0005268)2.03753895
125Pustule (HP:0200039)2.03600953
126Enlarged kidneys (HP:0000105)2.03267740
127Acanthocytosis (HP:0001927)2.01353175
128Dysostosis multiplex (HP:0000943)2.01112689
129Abnormal delayed hypersensitivity skin test (HP:0002963)2.00885484
130Renal cortical cysts (HP:0000803)1.97459179
131Hypophosphatemia (HP:0002148)1.96402266
132Bone cyst (HP:0012062)1.95909349
133Acute hepatic failure (HP:0006554)1.95893990
134Encephalitis (HP:0002383)1.95183904
135Tetany (HP:0001281)1.94294328
136Abnormality of polysaccharide metabolism (HP:0011012)1.94223884
137Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94223884
138Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94223884
139Sensorimotor neuropathy (HP:0007141)1.93707988
140Abnormal gallbladder morphology (HP:0012437)1.93169972
141Malnutrition (HP:0004395)1.92916736
142Tongue fasciculations (HP:0001308)1.92540851
143Keratoconjunctivitis sicca (HP:0001097)1.92285509
144Cerebral edema (HP:0002181)1.90289008
145Hypertriglyceridemia (HP:0002155)1.90206464
146Acne (HP:0001061)1.89289115
147Epiphyseal stippling (HP:0010655)1.87660428
148J-shaped sella turcica (HP:0002680)1.87612382
149Chronic obstructive pulmonary disease (HP:0006510)1.87239205
150Obstructive lung disease (HP:0006536)1.87239205
151Elevated hepatic transaminases (HP:0002910)1.87127125
152Petechiae (HP:0000967)1.86498381
153Oligomenorrhea (HP:0000876)1.86476002
154Arterial thrombosis (HP:0004420)1.86359274
155Vomiting (HP:0002013)1.84581647
156Neonatal onset (HP:0003623)1.84285174
157Abnormality of T cells (HP:0002843)1.83345474
158Abnormality of urine glucose concentration (HP:0011016)1.82960229
159Glycosuria (HP:0003076)1.82960229
160Abnormality of T cell physiology (HP:0011840)1.81843785
161Amyloidosis (HP:0011034)1.81353147
162Abnormal enzyme/coenzyme activity (HP:0012379)1.80447899
163Facial shape deformation (HP:0011334)1.79407835
164Potter facies (HP:0002009)1.79407835
165Hepatic necrosis (HP:0002605)1.79200874
166Myoglobinuria (HP:0002913)1.78636058
167Death in childhood (HP:0003819)1.78544321
168Esophageal varix (HP:0002040)1.77898056

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.62382219
2BCKDK4.86817481
3ERN14.52061913
4FLT33.61811036
5MAPK153.57560827
6SIK13.30151670
7TAOK32.78037108
8PASK2.62648068
9TNK22.60406404
10FGFR42.59976785
11TRIB32.17618729
12CAMK1D1.86722606
13FES1.81430430
14ZAP701.78866764
15RIPK41.70823329
16MAP2K31.66429546
17ACVR1B1.63478918
18TLK11.59435872
19TGFBR21.57497015
20ITK1.55932778
21PIK3CG1.54566212
22FRK1.52215333
23MST41.51973667
24PKN21.49299426
25TYK21.48931206
26HIPK21.43741941
27MAP4K11.42161281
28MAPK111.33561212
29IRAK31.31876141
30TBK11.31604091
31BTK1.29499630
32TRPM71.25069397
33JAK31.20511010
34DAPK21.20398925
35FGFR31.19735569
36PTK61.18512150
37GRK11.17143177
38EEF2K1.16612149
39BLK1.16277706
40PDPK11.14666284
41PRKD21.11833381
42JAK11.11807795
43CAMKK21.11426729
44TEC1.10787812
45CAMK1G1.10149222
46DYRK1B1.07371146
47KIT1.07010005
48JAK21.06052130
49PDK11.05527993
50CSK1.03627153
51MAPKAPK31.03243282
52EPHB11.01988533
53MAP3K131.01012463
54BMPR21.00099252
55CSF1R0.98013611
56PRKCQ0.95616958
57MAP2K60.94344228
58NLK0.92793048
59MAP2K40.92120269
60FGFR20.91937572
61MAP3K60.91823644
62HCK0.89035876
63PRKAA20.86762983
64STK100.83865811
65IRAK10.81513926
66WNK30.80907789
67KDR0.80760012
68CDK40.80569154
69PTK20.79457881
70IGF1R0.79057084
71MAP3K30.77314342
72EPHA30.77120467
73TESK20.76818383
74MAP3K100.76724988
75STK390.76052729
76ERBB40.75421806
77MAP4K20.73773851
78CDC42BPA0.73257674
79TAOK10.69336748
80MAP3K10.68794477
81SCYL20.65437019
82SYK0.64981723
83WNK40.63243231
84LRRK20.62805212
85STK380.62103835
86MUSK0.61541359
87IKBKE0.61103748
88TXK0.61074432
89PRPF4B0.60532845
90RIPK10.58963937
91MAP3K110.58151551
92EIF2AK30.57638836
93MET0.56565305
94PDGFRA0.55819835
95PHKG10.55605823
96PHKG20.55605823
97MST1R0.55577222
98MARK30.55177360
99EPHA20.54981351
100PRKACG0.52934022
101MAP2K20.52507636
102MAPK40.52503003
103MAP3K70.51832344
104LYN0.51542905
105PRKAA10.51472117
106MAP3K20.50749216
107RET0.50200467
108LCK0.50095011
109NEK90.49892539
110TESK10.48454010
111GSK3A0.48443012
112GRK60.45796586
113SMG10.45520110
114CDK30.43781038
115DYRK30.43641158
116BRSK20.41980884
117NTRK10.41511243
118FER0.41142957
119IRAK40.40187640
120ADRBK10.39320637
121PRKCI0.38789800
122PRKCH0.38679331
123RPS6KA40.37616647
124PRKG20.37496173
125TIE10.37306185
126IKBKB0.36552077
127MAPKAPK20.36238656
128RPS6KA60.35900074
129SIK30.34990068
130MTOR0.34495764
131CHUK0.34211868
132MAPK120.33842175
133IRAK20.33221489
134STK160.31922690
135ABL20.31290985
136CDK60.30322971
137ADRBK20.28057515
138PINK10.25721259
139MAP3K140.25656804
140PRKCZ0.23443520
141MAPK30.22124767
142CAMKK10.22031793
143MAP2K10.20857035

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.16547753
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.42970515
3Nitrogen metabolism_Homo sapiens_hsa009103.23933672
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.95120556
5Tryptophan metabolism_Homo sapiens_hsa003802.75287325
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65456419
7Fatty acid degradation_Homo sapiens_hsa000712.65365736
8Arginine biosynthesis_Homo sapiens_hsa002202.52017991
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.50082620
10Complement and coagulation cascades_Homo sapiens_hsa046102.43424891
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.34884503
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.27619288
13Peroxisome_Homo sapiens_hsa041462.16010096
14Butanoate metabolism_Homo sapiens_hsa006502.12670170
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.11228064
16Selenocompound metabolism_Homo sapiens_hsa004502.11019688
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.08650260
18PPAR signaling pathway_Homo sapiens_hsa033202.00663887
19Fatty acid metabolism_Homo sapiens_hsa012122.00139580
20Sulfur metabolism_Homo sapiens_hsa009201.99887171
21Primary immunodeficiency_Homo sapiens_hsa053401.99671087
22Propanoate metabolism_Homo sapiens_hsa006401.97392650
23Caffeine metabolism_Homo sapiens_hsa002321.95531119
24Staphylococcus aureus infection_Homo sapiens_hsa051501.86966970
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.85856488
26Histidine metabolism_Homo sapiens_hsa003401.80828854
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.78218114
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.71587649
29ABC transporters_Homo sapiens_hsa020101.70702128
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65000490
31beta-Alanine metabolism_Homo sapiens_hsa004101.62321341
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60416119
33Chemical carcinogenesis_Homo sapiens_hsa052041.59053684
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53323140
35Phenylalanine metabolism_Homo sapiens_hsa003601.52234192
36Graft-versus-host disease_Homo sapiens_hsa053321.49786149
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.49100705
38Folate biosynthesis_Homo sapiens_hsa007901.48912505
39Fatty acid elongation_Homo sapiens_hsa000621.47900914
40Allograft rejection_Homo sapiens_hsa053301.47889802
41Autoimmune thyroid disease_Homo sapiens_hsa053201.46288989
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.39720979
43Starch and sucrose metabolism_Homo sapiens_hsa005001.36891080
44Tyrosine metabolism_Homo sapiens_hsa003501.35749257
45Retinol metabolism_Homo sapiens_hsa008301.33168544
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32586190
47Leishmaniasis_Homo sapiens_hsa051401.31076637
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27712280
49Pyruvate metabolism_Homo sapiens_hsa006201.25568978
50Osteoclast differentiation_Homo sapiens_hsa043801.20297943
51Fat digestion and absorption_Homo sapiens_hsa049751.19435203
52Protein export_Homo sapiens_hsa030601.17931776
53Asthma_Homo sapiens_hsa053101.17207528
54Bile secretion_Homo sapiens_hsa049761.14735511
55Arachidonic acid metabolism_Homo sapiens_hsa005901.10352542
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09146681
57B cell receptor signaling pathway_Homo sapiens_hsa046621.08903170
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07715888
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.04198275
60Hematopoietic cell lineage_Homo sapiens_hsa046401.02985605
61Renin-angiotensin system_Homo sapiens_hsa046140.98839836
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.97819128
63Carbon metabolism_Homo sapiens_hsa012000.96498971
64T cell receptor signaling pathway_Homo sapiens_hsa046600.92393657
65Sphingolipid metabolism_Homo sapiens_hsa006000.92186365
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.90596228
67Lysine degradation_Homo sapiens_hsa003100.89730760
68Biosynthesis of amino acids_Homo sapiens_hsa012300.88446556
69Sulfur relay system_Homo sapiens_hsa041220.86975061
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86817801
71Glycerolipid metabolism_Homo sapiens_hsa005610.83931582
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80688677
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78131792
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.76506972
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72845897
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72161033
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72102213
78Measles_Homo sapiens_hsa051620.69665118
79Toxoplasmosis_Homo sapiens_hsa051450.69252966
80Vitamin B6 metabolism_Homo sapiens_hsa007500.68853873
81Arginine and proline metabolism_Homo sapiens_hsa003300.68609705
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67763977
83Tuberculosis_Homo sapiens_hsa051520.66156767
84Insulin resistance_Homo sapiens_hsa049310.64608865
85Acute myeloid leukemia_Homo sapiens_hsa052210.64147594
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64112900
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.63793509
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62796632
89Steroid biosynthesis_Homo sapiens_hsa001000.61616726
90Hepatitis C_Homo sapiens_hsa051600.60337332
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.58420460
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.57982515
93Prion diseases_Homo sapiens_hsa050200.56804238
94Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56764615
95TNF signaling pathway_Homo sapiens_hsa046680.53398275
96Rheumatoid arthritis_Homo sapiens_hsa053230.53389123
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53240967
98Vitamin digestion and absorption_Homo sapiens_hsa049770.52502860
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.51916625
100Pentose phosphate pathway_Homo sapiens_hsa000300.51702269
101Adipocytokine signaling pathway_Homo sapiens_hsa049200.51414437
102Mineral absorption_Homo sapiens_hsa049780.51352641
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50653773
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50400820
105Ether lipid metabolism_Homo sapiens_hsa005650.48913340
106African trypanosomiasis_Homo sapiens_hsa051430.48490839
107Influenza A_Homo sapiens_hsa051640.47076706
108Fatty acid biosynthesis_Homo sapiens_hsa000610.46470776
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46345518
110Galactose metabolism_Homo sapiens_hsa000520.46265614
111Other glycan degradation_Homo sapiens_hsa005110.45946221
112Metabolic pathways_Homo sapiens_hsa011000.44546841
113One carbon pool by folate_Homo sapiens_hsa006700.43151578
114Lysosome_Homo sapiens_hsa041420.38979139
115Glutathione metabolism_Homo sapiens_hsa004800.36198155
116Glucagon signaling pathway_Homo sapiens_hsa049220.36003217
117N-Glycan biosynthesis_Homo sapiens_hsa005100.34486953
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30906990
119Type II diabetes mellitus_Homo sapiens_hsa049300.30191841
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.27190813
121AMPK signaling pathway_Homo sapiens_hsa041520.25955099
122Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25892535
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25742695
124Regulation of autophagy_Homo sapiens_hsa041400.20673488
125Fructose and mannose metabolism_Homo sapiens_hsa000510.19843537
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15693445
127Circadian rhythm_Homo sapiens_hsa047100.14248198
128Linoleic acid metabolism_Homo sapiens_hsa005910.11138423
129Insulin signaling pathway_Homo sapiens_hsa049100.10486117
130Type I diabetes mellitus_Homo sapiens_hsa049400.10417792
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.08885055
132Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.03469112
133Insulin secretion_Homo sapiens_hsa049110.02715491
134Antigen processing and presentation_Homo sapiens_hsa046120.01144939
135Legionellosis_Homo sapiens_hsa051340.00823800
136Prolactin signaling pathway_Homo sapiens_hsa04917-0.0447424
137Pertussis_Homo sapiens_hsa05133-0.0163267
138RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.0049801

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