ABHD16A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: A cluster of genes, BAT1-BAT5, has been localized in the vicinity of the genes for tumor necrosis factor alpha and tumor necrosis factor beta. These genes are all within the human major histocompatibility complex class III region. The protein encoded by this gene is thought to be involved in some aspects of immunity. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)4.93234412
2neutrophil activation involved in immune response (GO:0002283)4.74038498
3oxygen transport (GO:0015671)4.42129941
4regulation of autophagic vacuole assembly (GO:2000785)4.12430747
5regulation of vacuole organization (GO:0044088)3.75642156
6sodium ion export (GO:0071436)3.72712921
7response to peptidoglycan (GO:0032494)3.68554000
8gas transport (GO:0015669)3.60435996
9sensory perception of smell (GO:0007608)3.59954798
10cellular potassium ion homeostasis (GO:0030007)3.56976518
11cellular response to zinc ion (GO:0071294)3.51841238
12Golgi transport vesicle coating (GO:0048200)3.48294257
13COPI coating of Golgi vesicle (GO:0048205)3.48294257
14regulation of mast cell degranulation (GO:0043304)3.39436300
15regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.37547183
16deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27886141
17valine metabolic process (GO:0006573)3.27051935
18immunoglobulin mediated immune response (GO:0016064)3.22872107
19modulation by symbiont of host defense response (GO:0052031)3.21881904
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.21881904
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.21881904
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.21881904
23modulation by symbiont of host immune response (GO:0052553)3.21881904
24positive regulation by symbiont of host defense response (GO:0052509)3.21881904
25synaptic vesicle maturation (GO:0016188)3.21360754
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19155868
27NADH metabolic process (GO:0006734)3.15408312
28tricarboxylic acid metabolic process (GO:0072350)3.12055315
29regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11595247
30autophagic vacuole fusion (GO:0000046)3.07542519
31cellular response to cadmium ion (GO:0071276)3.07111194
32activation of protein kinase A activity (GO:0034199)3.07012721
33negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06008673
34regulation of mast cell activation involved in immune response (GO:0033006)3.04344239
35neutrophil activation (GO:0042119)3.02343364
36oxaloacetate metabolic process (GO:0006107)3.02207553
37negative regulation of erythrocyte differentiation (GO:0045647)3.01688997
38cellular response to pH (GO:0071467)3.01665885
39lysine catabolic process (GO:0006554)3.00167873
40lysine metabolic process (GO:0006553)3.00167873
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97240913
42barbed-end actin filament capping (GO:0051016)2.92151611
43positive regulation of B cell differentiation (GO:0045579)2.91273257
44leukocyte migration involved in inflammatory response (GO:0002523)2.89288876
45negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89133778
46respiratory burst (GO:0045730)2.87210725
47positive regulation of gamma-delta T cell activation (GO:0046645)2.85210211
48succinate metabolic process (GO:0006105)2.84813795
49mitochondrion degradation (GO:0000422)2.84105127
50peroxisome fission (GO:0016559)2.83601070
51potassium ion homeostasis (GO:0055075)2.80681531
52positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.80652368
53potassium ion import (GO:0010107)2.79348439
54granulocyte activation (GO:0036230)2.78492995
55regulation of triglyceride catabolic process (GO:0010896)2.76330583
56tricarboxylic acid cycle (GO:0006099)2.76105899
57phagosome maturation (GO:0090382)2.75718245
58antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.75107189
59antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.75107189
60regulation of leukocyte degranulation (GO:0043300)2.74227921
612-oxoglutarate metabolic process (GO:0006103)2.73592068
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.72427910
63cell communication by electrical coupling (GO:0010644)2.71694081
64short-chain fatty acid metabolic process (GO:0046459)2.70826739
65synaptic vesicle exocytosis (GO:0016079)2.69192415
66actin filament polymerization (GO:0030041)2.68342073
67male meiosis (GO:0007140)2.66889880
68detection of other organism (GO:0098543)2.66846022
69synaptonemal complex assembly (GO:0007130)2.63208068
70regulation of cilium movement (GO:0003352)2.62688441
71thrombin receptor signaling pathway (GO:0070493)2.62274129
72sequestering of actin monomers (GO:0042989)2.61681386
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61573691
74detection of bacterium (GO:0016045)2.61215853
75cellular sodium ion homeostasis (GO:0006883)2.60901018
76neuromuscular process controlling posture (GO:0050884)2.58365699
77fatty acid beta-oxidation (GO:0006635)2.56710619
78alpha-linolenic acid metabolic process (GO:0036109)2.56119511
79regulation of regulated secretory pathway (GO:1903305)2.55287683
80regulation of mast cell activation (GO:0033003)2.53956419
81response to methylmercury (GO:0051597)2.53076086
82relaxation of smooth muscle (GO:0044557)2.52892959
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.52737114
84regulation of short-term neuronal synaptic plasticity (GO:0048172)2.52564473
85negative regulation of cell killing (GO:0031342)2.51040712
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.51040712
87positive regulation of mast cell activation (GO:0033005)2.49320973
88Arp2/3 complex-mediated actin nucleation (GO:0034314)2.49235305
89protein insertion into membrane (GO:0051205)2.48678402
90piRNA metabolic process (GO:0034587)2.48528828
91regulation of amyloid precursor protein catabolic process (GO:1902991)2.48517986
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.48166627
93fatty acid catabolic process (GO:0009062)2.47939255
94positive regulation of triglyceride biosynthetic process (GO:0010867)2.46037017
95positive regulation of mast cell degranulation (GO:0043306)2.45191832
96positive regulation of mast cell activation involved in immune response (GO:0033008)2.45191832
97aspartate family amino acid catabolic process (GO:0009068)2.44396882
98UV protection (GO:0009650)2.43759742
99detection of calcium ion (GO:0005513)2.43298810
100potassium ion export (GO:0071435)2.43209566
101regulation of synaptic vesicle exocytosis (GO:2000300)2.43149449
102neuronal action potential propagation (GO:0019227)2.43134015
103amino sugar catabolic process (GO:0046348)2.42646398
104positive regulation of catecholamine secretion (GO:0033605)2.42460322
105regulation of synaptic vesicle transport (GO:1902803)2.42294525
106protein polymerization (GO:0051258)2.41683883
107positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.41545892
108glutamate secretion (GO:0014047)2.41026047
109creatine metabolic process (GO:0006600)2.40735700
110virion assembly (GO:0019068)2.40495376
111protein retention in ER lumen (GO:0006621)2.40487080
112response to acidic pH (GO:0010447)2.39721574
113regulation of ARF GTPase activity (GO:0032312)2.39681580
114fatty acid oxidation (GO:0019395)2.37989396
115regulation of synapse structural plasticity (GO:0051823)2.36952005
116diacylglycerol metabolic process (GO:0046339)2.36896852
117erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.36779840
118L-phenylalanine metabolic process (GO:0006558)2.36779840
119lipid oxidation (GO:0034440)2.36714496
120heme biosynthetic process (GO:0006783)2.36320320
121phosphatidylglycerol biosynthetic process (GO:0006655)2.36297286
122xenobiotic catabolic process (GO:0042178)2.35711115
123adenosine receptor signaling pathway (GO:0001973)2.35488208
124negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)2.35321637
125transferrin transport (GO:0033572)2.35116432
126energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.34076946
127ATP hydrolysis coupled proton transport (GO:0015991)2.34076946
128myeloid cell activation involved in immune response (GO:0002275)2.33253961
129leukocyte degranulation (GO:0043299)2.33133101
130response to mercury ion (GO:0046689)2.32935041
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.32573264
132L-phenylalanine catabolic process (GO:0006559)2.32573264
133regulation of cellular extravasation (GO:0002691)2.32551461
134lipoxygenase pathway (GO:0019372)2.32143384
135sensory perception of chemical stimulus (GO:0007606)2.32068349
136positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.31781659
137regulation of oxidative phosphorylation (GO:0002082)2.31145032
138organelle membrane fusion (GO:0090174)2.30914060
139macrophage activation involved in immune response (GO:0002281)2.30441651
140synaptonemal complex organization (GO:0070193)2.30238038
141maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.29801387
142detection of external biotic stimulus (GO:0098581)2.29043163
143receptor recycling (GO:0001881)2.28709918
144regulation of sodium ion transmembrane transporter activity (GO:2000649)2.28433811
145regulation of beta-amyloid formation (GO:1902003)2.27440965
146positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.27316576
147cofactor catabolic process (GO:0051187)2.27269713
148positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.26577640
149viral protein processing (GO:0019082)2.25351875
150amyloid precursor protein catabolic process (GO:0042987)2.25326691
151membrane depolarization during action potential (GO:0086010)2.25283122
152regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.24382338
153sialylation (GO:0097503)2.23798375
154regulation of cholesterol biosynthetic process (GO:0045540)2.23756165
155pentose-phosphate shunt (GO:0006098)2.23711015
156fatty acid homeostasis (GO:0055089)2.23121795
157negative regulation of cytosolic calcium ion concentration (GO:0051481)2.23031220
158porphyrin-containing compound biosynthetic process (GO:0006779)2.22671560
159regulation of microtubule-based movement (GO:0060632)2.22656340
160mannose metabolic process (GO:0006013)2.22637719
161regulation of actin nucleation (GO:0051125)2.22506351
162ganglioside metabolic process (GO:0001573)2.22078699
163regulation of lipoprotein particle clearance (GO:0010984)2.22045317
164negative regulation of microtubule polymerization (GO:0031115)2.20423609
165regulation of fatty acid oxidation (GO:0046320)2.20423068
166regulation of hydrogen peroxide-induced cell death (GO:1903205)2.19715947
167cellular response to glucagon stimulus (GO:0071377)2.18930033
168acyl-CoA biosynthetic process (GO:0071616)2.18676800
169thioester biosynthetic process (GO:0035384)2.18676800
170glycogen catabolic process (GO:0005980)2.18103234
171membrane repolarization (GO:0086009)2.17764900
172sterol catabolic process (GO:0016127)2.17683961
173cholesterol catabolic process (GO:0006707)2.17683961
174beta-amyloid metabolic process (GO:0050435)2.17290702
175CDP-diacylglycerol metabolic process (GO:0046341)2.16775206
176cysteine metabolic process (GO:0006534)2.16450042
177monocarboxylic acid catabolic process (GO:0072329)2.15993093
178regulation of cholesterol metabolic process (GO:0090181)2.15437980
179detection of temperature stimulus involved in sensory perception (GO:0050961)2.15222649
180detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.15222649
181antigen processing and presentation of endogenous antigen (GO:0019883)2.14989101
182protein import into peroxisome matrix (GO:0016558)2.14964689
183mating behavior (GO:0007617)2.14742744
184macroautophagy (GO:0016236)2.14311342
185ethanol oxidation (GO:0006069)2.14072418
186activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12370200
187cell communication involved in cardiac conduction (GO:0086065)2.10698595
188heme metabolic process (GO:0042168)2.09976132
189regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.09784808
190membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.09364032
191sulfur amino acid catabolic process (GO:0000098)2.09256013
192cAMP biosynthetic process (GO:0006171)2.09044638
193neurotransmitter secretion (GO:0007269)2.06632674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.52934452
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.72249116
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.23297320
4GATA1_22025678_ChIP-Seq_K562_Human3.02285203
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.64385070
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.57809686
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.52592026
8ZNF263_19887448_ChIP-Seq_K562_Human2.50220317
9IRF8_21731497_ChIP-ChIP_J774_Mouse2.49749441
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.38343721
11ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.26182955
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19965193
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17646083
14LXR_22292898_ChIP-Seq_THP-1_Human2.11138701
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.07539049
16VDR_21846776_ChIP-Seq_THP-1_Human2.04141188
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.89254101
18SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.86209159
19GATA1_19941827_ChIP-Seq_MEL_Mouse1.86081220
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.84596414
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.81279135
22IKZF1_21737484_ChIP-ChIP_HCT116_Human1.74353746
23TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71424610
24EZH2_22144423_ChIP-Seq_EOC_Human1.71095010
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67949270
26SPI1_23547873_ChIP-Seq_NB4_Human1.66495538
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.64545058
28UTX_26944678_Chip-Seq_JUKART_Human1.64521662
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60671088
30GATA1_19941826_ChIP-Seq_K562_Human1.60424656
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60198240
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58123038
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.57899865
34DROSHA_22980978_ChIP-Seq_HELA_Human1.56285325
35SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.56013504
36CIITA_25753668_ChIP-Seq_RAJI_Human1.54473726
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51467931
38VDR_24763502_ChIP-Seq_THP-1_Human1.50160249
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48490712
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48333178
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.48110403
42PHF8_20622854_ChIP-Seq_HELA_Human1.47297903
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.45096509
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44426448
45CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43239459
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42965050
47SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.42872107
48PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42616421
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.42167267
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.40754274
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40505544
52SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.40268361
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40223935
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38821671
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.37912308
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.37297174
57ELF1_20517297_ChIP-Seq_JURKAT_Human1.36678281
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36387737
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34993626
60GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33730055
61TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32497405
62EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32105093
63MAF_26560356_Chip-Seq_TH2_Human1.31408694
64IRF8_27001747_Chip-Seq_BMDM_Mouse1.31271285
65CTCF_21964334_Chip-Seq_Bcells_Human1.31114612
66BCOR_27268052_Chip-Seq_Bcells_Human1.28690934
67KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28643826
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27312826
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27128409
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26396099
71REST_21632747_ChIP-Seq_MESCs_Mouse1.26327182
72E2F1_20622854_ChIP-Seq_HELA_Human1.26151119
73BCL6_27268052_Chip-Seq_Bcells_Human1.25824543
74RARB_27405468_Chip-Seq_BRAIN_Mouse1.25272569
75SMC4_20622854_ChIP-Seq_HELA_Human1.25138405
76P68_20966046_ChIP-Seq_HELA_Human1.23933372
77SPI1_20517297_ChIP-Seq_HL60_Human1.22486709
78SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20464273
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20281838
80CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20072369
81TET1_21451524_ChIP-Seq_MESCs_Mouse1.19747513
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19427703
83SUZ12_27294783_Chip-Seq_ESCs_Mouse1.19341582
84CTCF_20526341_ChIP-Seq_ESCs_Human1.19267576
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.19162352
86KDM2B_26808549_Chip-Seq_K562_Human1.18351549
87P300_27268052_Chip-Seq_Bcells_Human1.17467786
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.17258757
89EZH2_27294783_Chip-Seq_ESCs_Mouse1.17013775
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15741436
91NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15721714
92SPI1_23127762_ChIP-Seq_K562_Human1.15419561
93MAF_26560356_Chip-Seq_TH1_Human1.14853927
94ERA_21632823_ChIP-Seq_H3396_Human1.14435278
95CLOCK_20551151_ChIP-Seq_293T_Human1.14175280
96NCOR1_26117541_ChIP-Seq_K562_Human1.13814741
97RARG_19884340_ChIP-ChIP_MEFs_Mouse1.13806790
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13345419
99RAC3_21632823_ChIP-Seq_H3396_Human1.12694417
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.12155727
101CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11127320
102SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.10920637
103TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10838002
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10119190
105GATA2_19941826_ChIP-Seq_K562_Human1.10080350
106MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10059072
107CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09788644
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09286720
109CTCF_27219007_Chip-Seq_Bcells_Human1.09281823
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09115237
111RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08698248
112TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08642069
113LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08464059
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07739192
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.07543633
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07084209
117SA1_27219007_Chip-Seq_ERYTHROID_Human1.05723914
118ESR2_21235772_ChIP-Seq_MCF-7_Human1.04984973
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04766248
120STAT1_20625510_ChIP-Seq_HELA_Human1.04610275
121RAD21_21589869_ChIP-Seq_MESCs_Mouse1.04573408
122NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.02557684
123JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02388482
124SA1_27219007_Chip-Seq_Bcells_Human1.01775415
125SCL_19346495_ChIP-Seq_HPC-7_Human1.00321323
126KDM2B_26808549_Chip-Seq_DND41_Human0.99676841
127CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99199536
128TBX20_22080862_ChIP-Seq_HEART_Mouse0.98675749
129TBX20_22328084_ChIP-Seq_HEART_Mouse0.98675749
130TP63_22573176_ChIP-Seq_HFKS_Human0.97876137
131GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97406511
132NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96950616
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.95745163
134OCT4_20526341_ChIP-Seq_ESCs_Human0.93499694
135SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93282004
136SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92223898
137RACK7_27058665_Chip-Seq_MCF-7_Human0.92116690
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92050659
139SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91756185
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.91251196
141CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91242628
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91200984
143RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91200984
144MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90164393
145TAF2_19829295_ChIP-Seq_ESCs_Human0.90076645
146CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90016510
147ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88398848
148EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.88299919
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.88151141
150RUNX_20019798_ChIP-Seq_JUKART_Human0.87068462
151CREB1_26743006_Chip-Seq_LNCaP_Human0.87040764

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH3.95234588
2MP0003724_increased_susceptibility_to3.67899513
3MP0001984_abnormal_olfaction3.38094518
4MP0005464_abnormal_platelet_physiology3.22680492
5MP0003303_peritoneal_inflammation2.92153270
6MP0004147_increased_porphyrin_level2.81216642
7MP0003436_decreased_susceptibility_to2.75778179
8MP0002909_abnormal_adrenal_gland2.74582037
9MP0003656_abnormal_erythrocyte_physiolo2.70910111
10MP0003329_amyloid_beta_deposits2.61933507
11MP0002139_abnormal_hepatobiliary_system2.58199187
12MP0005058_abnormal_lysosome_morphology2.54858361
13MP0009840_abnormal_foam_cell2.47831989
14MP0002132_abnormal_respiratory_system2.35320885
15MP0004859_abnormal_synaptic_plasticity2.34619056
16MP0002837_dystrophic_cardiac_calcinosis2.32176425
17MP0008260_abnormal_autophagy2.30152809
18MP0009278_abnormal_bone_marrow2.22762615
19MP0001545_abnormal_hematopoietic_system2.20861871
20MP0005397_hematopoietic_system_phenotyp2.20861871
21MP0000343_altered_response_to2.16805445
22MP0003191_abnormal_cellular_cholesterol2.12115058
23MP0004145_abnormal_muscle_electrophysio2.08042477
24MP0000013_abnormal_adipose_tissue2.06096896
25MP0004043_abnormal_pH_regulation2.00265225
26MP0004130_abnormal_muscle_cell1.94962763
27MP0002419_abnormal_innate_immunity1.94476001
28MP0000465_gastrointestinal_hemorrhage1.93989857
29MP0001835_abnormal_antigen_presentation1.91969204
30MP0005025_abnormal_response_to1.88423177
31MP0009785_altered_susceptibility_to1.84246655
32MP0005360_urolithiasis1.83284566
33MP0000604_amyloidosis1.80809847
34MP0006036_abnormal_mitochondrial_physio1.70253782
35MP0008875_abnormal_xenobiotic_pharmacok1.70226268
36MP0001905_abnormal_dopamine_level1.68198439
37MP0000751_myopathy1.67473831
38MP0005365_abnormal_bile_salt1.67260621
39MP0001529_abnormal_vocalization1.65400652
40MP0003172_abnormal_lysosome_physiology1.65021975
41MP0000569_abnormal_digit_pigmentation1.64765185
42MP0003646_muscle_fatigue1.62521974
43MP0003635_abnormal_synaptic_transmissio1.62376820
44MP0002148_abnormal_hypersensitivity_rea1.61920258
45MP0010329_abnormal_lipoprotein_level1.60936968
46MP0004215_abnormal_myocardial_fiber1.58534063
47MP0005394_taste/olfaction_phenotype1.55421581
48MP0005499_abnormal_olfactory_system1.55421581
49MP0005000_abnormal_immune_tolerance1.54455923
50MP0003806_abnormal_nucleotide_metabolis1.53570803
51MP0002822_catalepsy1.53308297
52MP0009046_muscle_twitch1.52664612
53MP0005670_abnormal_white_adipose1.50712773
54MP0005083_abnormal_biliary_tract1.48082228
55MP0005451_abnormal_body_composition1.45773513
56MP0006082_CNS_inflammation1.44906904
57MP0002272_abnormal_nervous_system1.44771020
58MP0000749_muscle_degeneration1.41900932
59MP0003195_calcinosis1.41871175
60MP0004858_abnormal_nervous_system1.41834138
61MP0005584_abnormal_enzyme/coenzyme_acti1.41168679
62MP0008569_lethality_at_weaning1.40214920
63MP0005085_abnormal_gallbladder_physiolo1.39317586
64MP0008789_abnormal_olfactory_epithelium1.36668900
65MP0005166_decreased_susceptibility_to1.36630022
66MP0004036_abnormal_muscle_relaxation1.36446152
67MP0001533_abnormal_skeleton_physiology1.34715205
68MP0003075_altered_response_to1.34449770
69MP0002064_seizures1.34231058
70MP0010386_abnormal_urinary_bladder1.33001548
71MP0000747_muscle_weakness1.31420661
72MP0002723_abnormal_immune_serum1.29021678
73MP0003828_pulmonary_edema1.28221635
74MP0009643_abnormal_urine_homeostasis1.27835968
75MP0005535_abnormal_body_temperature1.27475276
76MP0002118_abnormal_lipid_homeostasis1.27181205
77MP0003183_abnormal_peptide_metabolism1.26976864
78MP0003633_abnormal_nervous_system1.26955825
79MP0005636_abnormal_mineral_homeostasis1.25960933
80MP0001765_abnormal_ion_homeostasis1.24935566
81MP0002420_abnormal_adaptive_immunity1.24644339
82MP0002078_abnormal_glucose_homeostasis1.24303862
83MP0006054_spinal_hemorrhage1.23707106
84MP0001790_abnormal_immune_system1.23075145
85MP0005387_immune_system_phenotype1.23075145
86MP0004510_myositis1.23029315
87MP0001819_abnormal_immune_cell1.22578325
88MP0000003_abnormal_adipose_tissue1.18961801
89MP0000015_abnormal_ear_pigmentation1.18441110
90MP0001968_abnormal_touch/_nociception1.18243334
91MP0002452_abnormal_antigen_presenting1.16366660
92MP0001502_abnormal_circadian_rhythm1.15459092
93MP0008961_abnormal_basal_metabolism1.15050307
94MP0002733_abnormal_thermal_nociception1.14153636
95MP0001800_abnormal_humoral_immune1.13788309
96MP0004270_analgesia1.12929414
97MP0005645_abnormal_hypothalamus_physiol1.12249130
98MP0002269_muscular_atrophy1.11712940
99MP0001501_abnormal_sleep_pattern1.11299433
100MP0001845_abnormal_inflammatory_respons1.10997879
101MP0003252_abnormal_bile_duct1.10346298
102MP0002735_abnormal_chemical_nociception1.10077098
103MP0008469_abnormal_protein_level1.09926537
104MP0005332_abnormal_amino_acid1.09309972
105MP0001986_abnormal_taste_sensitivity1.07457016
106MP0002734_abnormal_mechanical_nocicepti1.07266852
107MP0009745_abnormal_behavioral_response1.07131469
108MP0010155_abnormal_intestine_physiology1.05978171
109MP0003879_abnormal_hair_cell1.05377036
110MP0001970_abnormal_pain_threshold1.04556100
111MP0002736_abnormal_nociception_after1.03021941
112MP0005671_abnormal_response_to1.02394649
113MP0000230_abnormal_systemic_arterial1.02054582
114MP0002067_abnormal_sensory_capabilities1.01234650
115MP0002063_abnormal_learning/memory/cond1.00271959
116MP0005319_abnormal_enzyme/_coenzyme0.99562101
117MP0001666_abnormal_nutrient_absorption0.97936952
118MP0005167_abnormal_blood-brain_barrier0.97488295
119MP0000372_irregular_coat_pigmentation0.96626529
120MP0002090_abnormal_vision0.95398790
121MP0000609_abnormal_liver_physiology0.94955534
122MP0002653_abnormal_ependyma_morphology0.94922862
123MP0009765_abnormal_xenobiotic_induced0.94597569
124MP0001944_abnormal_pancreas_morphology0.93699639
125MP0002277_abnormal_respiratory_mucosa0.90416392
126MP0008995_early_reproductive_senescence0.89788807
127MP0005410_abnormal_fertilization0.89605856
128MP0001764_abnormal_homeostasis0.89061300
129MP0002693_abnormal_pancreas_physiology0.87760026
130MP0002971_abnormal_brown_adipose0.87682575
131MP0005448_abnormal_energy_balance0.84225932
132MP0003880_abnormal_central_pattern0.84133538
133MP0005375_adipose_tissue_phenotype0.83321722
134MP0008872_abnormal_physiological_respon0.83219195
135MP0001756_abnormal_urination0.83135516
136MP0003631_nervous_system_phenotype0.82966153
137MP0003315_abnormal_perineum_morphology0.82775367
138MP0005334_abnormal_fat_pad0.82513408
139MP0002229_neurodegeneration0.82475954
140MP0009764_decreased_sensitivity_to0.81054570
141MP0005330_cardiomyopathy0.79993405
142MP0002572_abnormal_emotion/affect_behav0.79992589
143MP0003186_abnormal_redox_activity0.79378406
144MP0006035_abnormal_mitochondrial_morpho0.79016197
145MP0006276_abnormal_autonomic_nervous0.78836369
146MP0002184_abnormal_innervation0.78691468
147MP0002722_abnormal_immune_system0.78225812
148MP0000716_abnormal_immune_system0.77936093
149MP0005646_abnormal_pituitary_gland0.77813955
150MP0008874_decreased_physiological_sensi0.77188708
151MP0003690_abnormal_glial_cell0.76908142
152MP0001664_abnormal_digestion0.76203827
153MP0004084_abnormal_cardiac_muscle0.76194594
154MP0003953_abnormal_hormone_level0.75308119
155MP0000685_abnormal_immune_system0.74547026
156MP0000689_abnormal_spleen_morphology0.73735690
157MP0009763_increased_sensitivity_to0.73295908
158MP0002398_abnormal_bone_marrow0.72248824
159MP0002405_respiratory_system_inflammati0.71481042
160MP0003698_abnormal_male_reproductive0.71369027
161MP0003638_abnormal_response/metabolism_0.70858060
162MP0002429_abnormal_blood_cell0.69925494
163MP0004883_abnormal_blood_vessel0.67443328
164MP0002332_abnormal_exercise_endurance0.65175613
165MP0004381_abnormal_hair_follicle0.65021415
166MP0002998_abnormal_bone_remodeling0.63318499
167MP0001929_abnormal_gametogenesis0.62838578
168MP0001849_ear_inflammation0.62257742
169MP0005075_abnormal_melanosome_morpholog0.60360274

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of macrophages (HP:0004311)3.86250167
2Petechiae (HP:0000967)3.75956929
3Recurrent abscess formation (HP:0002722)3.71054967
4Purpura (HP:0000979)3.67876909
5Prolonged bleeding time (HP:0003010)3.65305875
6Recurrent bacterial skin infections (HP:0005406)3.50322383
7Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.42077528
8Ketoacidosis (HP:0001993)3.34869038
9Abnormality of the heme biosynthetic pathway (HP:0010472)3.23355579
10Dysostosis multiplex (HP:0000943)3.20613952
11Eczematoid dermatitis (HP:0000976)3.13825020
12Systemic lupus erythematosus (HP:0002725)3.05874115
13Ketosis (HP:0001946)2.95899228
14Exercise-induced myalgia (HP:0003738)2.93786200
15Polyphagia (HP:0002591)2.89786675
16Late onset (HP:0003584)2.89036159
17Pheochromocytoma (HP:0002666)2.85810178
18Abnormal gallbladder physiology (HP:0012438)2.85353043
19Cholecystitis (HP:0001082)2.85353043
20Epistaxis (HP:0000421)2.85263945
21Visual hallucinations (HP:0002367)2.84551951
22Retinal dysplasia (HP:0007973)2.79148063
23Obstructive lung disease (HP:0006536)2.79050438
24Chronic obstructive pulmonary disease (HP:0006510)2.79050438
25Myoglobinuria (HP:0002913)2.73205263
26Neuroendocrine neoplasm (HP:0100634)2.72332891
27Amyloidosis (HP:0011034)2.71049832
28Abnormality of aromatic amino acid family metabolism (HP:0004338)2.70239799
29Stomatitis (HP:0010280)2.67674493
30Recurrent gram-negative bacterial infections (HP:0005420)2.64432756
31Abnormality of lateral ventricle (HP:0030047)2.58524141
32Absent speech (HP:0001344)2.56340390
33Increased cerebral lipofuscin (HP:0011813)2.55937004
34Abnormal hemoglobin (HP:0011902)2.54941747
35Mucopolysacchariduria (HP:0008155)2.54348670
36Urinary glycosaminoglycan excretion (HP:0003541)2.54348670
37Colitis (HP:0002583)2.54201439
38Supranuclear gaze palsy (HP:0000605)2.54164051
39Vacuolated lymphocytes (HP:0001922)2.54146340
40Hypoglycemic coma (HP:0001325)2.52534278
41Spontaneous hematomas (HP:0007420)2.51654804
42Mutism (HP:0002300)2.49091393
43Gingival bleeding (HP:0000225)2.42362690
44Palpitations (HP:0001962)2.42077553
45Gout (HP:0001997)2.41178618
46Menorrhagia (HP:0000132)2.41122723
47Asymmetric septal hypertrophy (HP:0001670)2.40711566
48Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40243629
49Abnormality of polysaccharide metabolism (HP:0011012)2.40243629
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40243629
51Myositis (HP:0100614)2.39939004
52Elevated erythrocyte sedimentation rate (HP:0003565)2.39891990
53Oligomenorrhea (HP:0000876)2.38386208
54Loss of speech (HP:0002371)2.36047868
55Cholelithiasis (HP:0001081)2.36016839
56Growth hormone excess (HP:0000845)2.35606059
57Myokymia (HP:0002411)2.35454308
58Neurofibrillary tangles (HP:0002185)2.32838209
59Abnormal gallbladder morphology (HP:0012437)2.30431758
60Action tremor (HP:0002345)2.30231360
61Depression (HP:0000716)2.30003798
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.29986266
63Acute hepatic failure (HP:0006554)2.28938067
64Mediastinal lymphadenopathy (HP:0100721)2.25794209
65Increased neuronal autofluorescent lipopigment (HP:0002074)2.25729115
66Increased IgM level (HP:0003496)2.24613939
67Poikilocytosis (HP:0004447)2.22179563
68Polycythemia (HP:0001901)2.21786604
69Type II lissencephaly (HP:0007260)2.21274576
70Reduced antithrombin III activity (HP:0001976)2.20231298
71Hepatocellular necrosis (HP:0001404)2.19491934
72Gastrointestinal inflammation (HP:0004386)2.19018226
73Microcytic anemia (HP:0001935)2.18833388
74Agitation (HP:0000713)2.18624609
75Clumsiness (HP:0002312)2.18554185
76Increased serum ferritin (HP:0003281)2.17684677
77Abnormality of the nasal mucosa (HP:0000433)2.17357587
78Hyperbilirubinemia (HP:0002904)2.17294573
79Hepatosplenomegaly (HP:0001433)2.17162547
80Abnormality of fatty-acid metabolism (HP:0004359)2.16643120
81Anxiety (HP:0000739)2.15649457
82Reticulocytosis (HP:0001923)2.15378807
83Rimmed vacuoles (HP:0003805)2.15230916
84Postural instability (HP:0002172)2.13846722
85Abnormality of alanine metabolism (HP:0010916)2.13708966
86Hyperalaninemia (HP:0003348)2.13708966
87Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.13708966
88Centrally nucleated skeletal muscle fibers (HP:0003687)2.12937886
89Inflammation of the large intestine (HP:0002037)2.11989872
90Central scotoma (HP:0000603)2.11817927
91Craniofacial dystonia (HP:0012179)2.10875107
92Torticollis (HP:0000473)2.10688470
93Abnormal platelet function (HP:0011869)2.09092735
94Impaired platelet aggregation (HP:0003540)2.09092735
95Abnormal platelet volume (HP:0011876)2.08456727
96Hypoglycemic seizures (HP:0002173)2.07359523
97Granulocytopenia (HP:0001913)2.07073541
98Generalized aminoaciduria (HP:0002909)2.06710859
99Hypercortisolism (HP:0001578)2.06707270
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05685346
101Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05685346
102Xanthomatosis (HP:0000991)2.03099781
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03076022
104Thoracic kyphosis (HP:0002942)2.00665709
105Hand muscle atrophy (HP:0009130)1.99338528
106Hyperinsulinemic hypoglycemia (HP:0000825)1.99256342
107Neuronal loss in central nervous system (HP:0002529)1.99136264
108Absent rod-and cone-mediated responses on ERG (HP:0007688)1.98942411
109Brushfield spots (HP:0001088)1.98303109
110Ragged-red muscle fibers (HP:0003200)1.98207059
111Focal dystonia (HP:0004373)1.97446768
112Abnormal pupillary function (HP:0007686)1.95695851
113Recurrent skin infections (HP:0001581)1.95534584
114Cerebral hemorrhage (HP:0001342)1.94031425
115Nasal polyposis (HP:0100582)1.93439856
116Encephalitis (HP:0002383)1.92768133
117Abnormality of liposaccharide metabolism (HP:0010968)1.92167434
118Abnormality of glycosphingolipid metabolism (HP:0004343)1.92167434
119Abnormality of glycolipid metabolism (HP:0010969)1.92167434
120Abnormality of purine metabolism (HP:0004352)1.92035302
121Abnormality of iron homeostasis (HP:0011031)1.91559223
122Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89997751
123Myotonia (HP:0002486)1.89992420
124Dicarboxylic aciduria (HP:0003215)1.89490260
125Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89490260
126Amyotrophic lateral sclerosis (HP:0007354)1.88997865
127Hyperammonemia (HP:0001987)1.88657384
128Urticaria (HP:0001025)1.88119052
129Global brain atrophy (HP:0002283)1.88028831
130Diminished motivation (HP:0000745)1.87721621
131Gonadal dysgenesis (HP:0000133)1.87212711
132Abnormality of macular pigmentation (HP:0008002)1.87073175
133Retinal atrophy (HP:0001105)1.87065412
134Prolonged neonatal jaundice (HP:0006579)1.86677303
135Orchitis (HP:0100796)1.86035150
136Ankle clonus (HP:0011448)1.85456295
137Increased muscle lipid content (HP:0009058)1.85144648
138Apathy (HP:0000741)1.85135814
139Increased mean platelet volume (HP:0011877)1.84596324
140Muscle stiffness (HP:0003552)1.84236997
141Cerebral inclusion bodies (HP:0100314)1.83802763
142Tinnitus (HP:0000360)1.83241880
143Hypertriglyceridemia (HP:0002155)1.82256905
144Panhypogammaglobulinemia (HP:0003139)1.81958623
145Peripheral hypomyelination (HP:0007182)1.81505710
146Cardiomegaly (HP:0001640)1.80859735
147Atonic seizures (HP:0010819)1.79862984
148Abnormality of the gallbladder (HP:0005264)1.76907245
149Disinhibition (HP:0000734)1.76805573
150Deep venous thrombosis (HP:0002625)1.76696227
151Ventricular fibrillation (HP:0001663)1.76659416
152Abnormal eating behavior (HP:0100738)1.75507822
153Hepatic necrosis (HP:0002605)1.75112853
154Sensorimotor neuropathy (HP:0007141)1.75056142
155Hyperlipoproteinemia (HP:0010980)1.73500501
156Atrophy/Degeneration involving motor neurons (HP:0007373)1.73303244
157Decreased circulating renin level (HP:0003351)1.72397672
158Delusions (HP:0000746)1.72385865
159Failure to thrive in infancy (HP:0001531)1.72202936
160Large for gestational age (HP:0001520)1.72141428
161Hyperactive renin-angiotensin system (HP:0000841)1.71565444
162Recurrent fungal infections (HP:0002841)1.70639087
163Psychosis (HP:0000709)1.70225401
164Intention tremor (HP:0002080)1.70173898
165Facial diplegia (HP:0001349)1.69934639
166Upper limb amyotrophy (HP:0009129)1.69730610
167Distal upper limb amyotrophy (HP:0007149)1.69730610

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK23.44970814
2TRIB33.20414112
3MARK33.05951838
4CAMKK23.03873236
5ERN12.96199003
6BCKDK2.86193676
7PHKG12.36328524
8PHKG22.36328524
9MAPK152.33979023
10LMTK22.32510782
11ARAF2.31193655
12KSR22.19869275
13CSNK1G31.95346710
14NTRK11.90518145
15DAPK21.89050841
16NME21.86677236
17MAP3K91.85694310
18TAOK31.77360298
19CAMKK11.71666715
20CSNK1G21.68675662
21PIM21.65744834
22TESK11.63469264
23PRKD31.63251247
24SCYL21.60266223
25CSNK1A1L1.57195559
26KDR1.54814235
27GRK61.52731827
28MAPKAPK51.50212462
29MAP4K21.47047027
30SIK11.44370112
31TNK21.35150997
32MAP3K131.34536039
33TYK21.31218476
34FLT31.30511613
35MAPKAPK31.28931352
36CSNK1G11.26404180
37FGR1.25764162
38MAP3K51.21341339
39PRPF4B1.16490574
40ZAP701.15049559
41MAP3K11.13910165
42CDK191.13300725
43INSRR1.10336507
44DYRK31.10190594
45ABL21.09953671
46SYK1.09543246
47TGFBR21.07948984
48RET1.07686047
49PAK61.07630616
50RIPK11.06402015
51TBK11.05463810
52EEF2K1.05286057
53PKN21.01860872
54GRK51.01717396
55BMX1.00855761
56HIPK21.00577939
57TIE10.98349440
58HCK0.98108428
59JAK10.96490677
60DYRK20.96182148
61PDK30.96155329
62PDK40.96155329
63RPS6KA50.95239425
64MAP3K30.93726247
65NTRK30.93665436
66MAP4K10.93222281
67PINK10.93109632
68PTK2B0.92542772
69PDPK10.90704210
70EPHA30.90624052
71EPHB10.88872758
72MINK10.87883553
73STK380.87854988
74MOS0.87501794
75SIK20.87057931
76TAOK10.86302841
77MAP2K40.86215354
78PRKCH0.85784259
79CSK0.84722758
80JAK20.84335178
81ZAK0.83850523
82IRAK20.83570672
83MAP3K20.83454002
84CCNB10.82652189
85TAOK20.82341808
86MAP3K120.82195808
87GRK70.81025438
88PTK60.80952767
89WNK30.80533307
90MATK0.80023633
91CAMK2G0.79851219
92PDK10.79676270
93OBSCN0.79241374
94PDK20.79235358
95MYLK0.78482880
96CSF1R0.78428370
97LYN0.76841999
98MAPK130.76482743
99DAPK10.75729505
100WNK40.75134042
101PIK3CG0.74684044
102RAF10.74647419
103MAPK120.74337263
104BLK0.73239762
105CAMK10.72323251
106SIK30.72314586
107PTK20.71973296
108MAP3K110.71711341
109CDK80.71667036
110MAP2K10.70424736
111PRKCQ0.69869195
112CDK50.68051561
113KIT0.68021440
114CAMK2D0.67712662
115PKN10.67596563
116PAK10.66708933
117PAK30.65094197
118MAP3K70.63085370
119MUSK0.60479327
120JAK30.59099157
121CDK140.58299197
122DYRK1B0.58134073
123TTN0.57644288
124IRAK40.57377119
125RPS6KA40.57370398
126ITK0.56509908
127IRAK30.54902392
128IKBKB0.54735132
129MAPK110.54570600
130IKBKE0.53787017
131PRKG20.53102069
132CAMK1G0.52707542
133PRKAA10.51564725
134MAP2K30.49212395
135MARK10.48425364
136BRAF0.47688949
137MAP3K40.45495506
138BTK0.45474518
139MAP2K20.45180588
140TLK10.45058379
141RIPK40.44657856
142FGFR40.44384812
143TEC0.44034676
144DAPK30.43724282
145ADRBK20.42102170
146NEK90.42071101
147CAMK2B0.41543542
148FES0.41095961
149SGK2230.40375517
150SGK4940.40375517
151MARK20.39209510
152MAP2K70.38847519

Predicted pathways (KEGG)

RankGene SetZ-score
1Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.13093220
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.88420693
3Phagosome_Homo sapiens_hsa041452.68964860
4Olfactory transduction_Homo sapiens_hsa047402.56669592
5Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.51884044
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.39963442
7Staphylococcus aureus infection_Homo sapiens_hsa051502.39743179
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.16131930
9Synaptic vesicle cycle_Homo sapiens_hsa047212.03740816
10Fatty acid degradation_Homo sapiens_hsa000711.90520079
11Propanoate metabolism_Homo sapiens_hsa006401.83820399
12Leishmaniasis_Homo sapiens_hsa051401.83379009
13Phenylalanine metabolism_Homo sapiens_hsa003601.75943370
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.75506631
15Other glycan degradation_Homo sapiens_hsa005111.70367588
16Pyruvate metabolism_Homo sapiens_hsa006201.67487269
17Osteoclast differentiation_Homo sapiens_hsa043801.66988243
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.65743184
19Insulin secretion_Homo sapiens_hsa049111.64599124
20Tuberculosis_Homo sapiens_hsa051521.63642993
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62313604
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.60366764
23Regulation of autophagy_Homo sapiens_hsa041401.58525986
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54495669
25Lysosome_Homo sapiens_hsa041421.53329428
26Asthma_Homo sapiens_hsa053101.50059253
27Allograft rejection_Homo sapiens_hsa053301.49445317
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43429432
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.42350217
30Fatty acid metabolism_Homo sapiens_hsa012121.41544952
31Bile secretion_Homo sapiens_hsa049761.40170094
32Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39863377
33Rheumatoid arthritis_Homo sapiens_hsa053231.34930247
34Sulfur relay system_Homo sapiens_hsa041221.32663474
35Caffeine metabolism_Homo sapiens_hsa002321.30617101
36Circadian entrainment_Homo sapiens_hsa047131.27407222
37PPAR signaling pathway_Homo sapiens_hsa033201.26821086
38Pertussis_Homo sapiens_hsa051331.25092808
39Autoimmune thyroid disease_Homo sapiens_hsa053201.23360129
40Carbon metabolism_Homo sapiens_hsa012001.23158548
41Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23148715
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.22014693
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21435953
44ABC transporters_Homo sapiens_hsa020101.21238254
45Peroxisome_Homo sapiens_hsa041461.19908502
46Salivary secretion_Homo sapiens_hsa049701.19905683
47GABAergic synapse_Homo sapiens_hsa047271.17025092
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16689986
49Sulfur metabolism_Homo sapiens_hsa009201.16396456
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14786726
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13116099
52Nitrogen metabolism_Homo sapiens_hsa009101.12484697
53Graft-versus-host disease_Homo sapiens_hsa053321.12021801
54Malaria_Homo sapiens_hsa051441.11292355
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10706909
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08489924
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.08038882
58B cell receptor signaling pathway_Homo sapiens_hsa046621.07824512
59Legionellosis_Homo sapiens_hsa051341.06860736
60Arachidonic acid metabolism_Homo sapiens_hsa005901.06480522
61Vibrio cholerae infection_Homo sapiens_hsa051101.05972931
62Collecting duct acid secretion_Homo sapiens_hsa049661.05731306
63Apoptosis_Homo sapiens_hsa042101.05188605
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.03924074
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03370238
66Gastric acid secretion_Homo sapiens_hsa049711.03283808
67Morphine addiction_Homo sapiens_hsa050321.03266826
68Glycosaminoglycan degradation_Homo sapiens_hsa005311.02365236
69Taste transduction_Homo sapiens_hsa047421.02136563
70Gap junction_Homo sapiens_hsa045400.99129460
71Chemical carcinogenesis_Homo sapiens_hsa052040.98885652
72Tyrosine metabolism_Homo sapiens_hsa003500.98548370
73Glutathione metabolism_Homo sapiens_hsa004800.98546450
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98425996
75Platelet activation_Homo sapiens_hsa046110.98272161
76Hematopoietic cell lineage_Homo sapiens_hsa046400.98069495
77Shigellosis_Homo sapiens_hsa051310.97208674
78Butanoate metabolism_Homo sapiens_hsa006500.96358941
79Type II diabetes mellitus_Homo sapiens_hsa049300.95554956
80Pancreatic secretion_Homo sapiens_hsa049720.94391649
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93455308
82Type I diabetes mellitus_Homo sapiens_hsa049400.92835452
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.92471864
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.91328863
85Cardiac muscle contraction_Homo sapiens_hsa042600.90754668
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89288126
87Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88478014
88Glutamatergic synapse_Homo sapiens_hsa047240.86224926
89Acute myeloid leukemia_Homo sapiens_hsa052210.86110205
90Salmonella infection_Homo sapiens_hsa051320.84119072
91Tryptophan metabolism_Homo sapiens_hsa003800.83775785
92Cholinergic synapse_Homo sapiens_hsa047250.83403077
93N-Glycan biosynthesis_Homo sapiens_hsa005100.82370628
94Long-term potentiation_Homo sapiens_hsa047200.81984156
95Selenocompound metabolism_Homo sapiens_hsa004500.81609444
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81235273
97Thyroid hormone synthesis_Homo sapiens_hsa049180.81067608
98Chemokine signaling pathway_Homo sapiens_hsa040620.80570576
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79752715
100Pentose phosphate pathway_Homo sapiens_hsa000300.79580533
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79379093
102Glycerolipid metabolism_Homo sapiens_hsa005610.78865178
103Nicotine addiction_Homo sapiens_hsa050330.78744931
104Renin secretion_Homo sapiens_hsa049240.78715875
105Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78663078
106Fructose and mannose metabolism_Homo sapiens_hsa000510.78082406
107Antigen processing and presentation_Homo sapiens_hsa046120.77322622
108Amphetamine addiction_Homo sapiens_hsa050310.77206854
109Arginine biosynthesis_Homo sapiens_hsa002200.76903800
110Calcium signaling pathway_Homo sapiens_hsa040200.76712226
111Dopaminergic synapse_Homo sapiens_hsa047280.76599274
112Starch and sucrose metabolism_Homo sapiens_hsa005000.74780235
113Glucagon signaling pathway_Homo sapiens_hsa049220.74139475
114Fatty acid biosynthesis_Homo sapiens_hsa000610.73070656
115Drug metabolism - other enzymes_Homo sapiens_hsa009830.72162091
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72105021
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.71926621
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71833470
119Insulin resistance_Homo sapiens_hsa049310.70997925
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70108807
121cAMP signaling pathway_Homo sapiens_hsa040240.69244583
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.68996242
123Insulin signaling pathway_Homo sapiens_hsa049100.68131083
124Galactose metabolism_Homo sapiens_hsa000520.67931146
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67830372
126Viral myocarditis_Homo sapiens_hsa054160.67556408
127Herpes simplex infection_Homo sapiens_hsa051680.67363479
128Toxoplasmosis_Homo sapiens_hsa051450.66030593
129Complement and coagulation cascades_Homo sapiens_hsa046100.64280412
130Biosynthesis of amino acids_Homo sapiens_hsa012300.64110214
131Oxytocin signaling pathway_Homo sapiens_hsa049210.63277446
132Cocaine addiction_Homo sapiens_hsa050300.62631336
133Systemic lupus erythematosus_Homo sapiens_hsa053220.60978767
134Fatty acid elongation_Homo sapiens_hsa000620.60833789
135Influenza A_Homo sapiens_hsa051640.60512703
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.59692530
137Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59467674
138Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59278079
139beta-Alanine metabolism_Homo sapiens_hsa004100.58470232
140Oxidative phosphorylation_Homo sapiens_hsa001900.57788439
141Folate biosynthesis_Homo sapiens_hsa007900.57720823
142Parkinsons disease_Homo sapiens_hsa050120.57516612
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57302692
144Endocytosis_Homo sapiens_hsa041440.56775706
145Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55370490
146Alzheimers disease_Homo sapiens_hsa050100.55369220
147Mineral absorption_Homo sapiens_hsa049780.55056841
148SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53492016
149Fat digestion and absorption_Homo sapiens_hsa049750.53400628
150Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50972797
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50598346
152Estrogen signaling pathway_Homo sapiens_hsa049150.48071601
153Alcoholism_Homo sapiens_hsa050340.47695562
154AMPK signaling pathway_Homo sapiens_hsa041520.47195477
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46890286
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46878552
157Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46593273
158Huntingtons disease_Homo sapiens_hsa050160.46476951
159Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45884766
160Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45700448
161GnRH signaling pathway_Homo sapiens_hsa049120.45495416
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44575525
163Primary immunodeficiency_Homo sapiens_hsa053400.43081004
164Sphingolipid signaling pathway_Homo sapiens_hsa040710.42140772
165NF-kappa B signaling pathway_Homo sapiens_hsa040640.39420808
166RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.37855446
167Hepatitis C_Homo sapiens_hsa051600.36970226
168VEGF signaling pathway_Homo sapiens_hsa043700.36627390

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