ABHD16B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.78954651
2spermatid development (GO:0007286)9.70962462
3epithelial cilium movement (GO:0003351)9.59141806
4regulation of cilium movement (GO:0003352)9.41551036
5plasma membrane fusion (GO:0045026)9.15973236
6reproduction (GO:0000003)8.71890324
7cilium or flagellum-dependent cell motility (GO:0001539)7.78740086
8cilium movement (GO:0003341)7.74615185
9negative regulation of inclusion body assembly (GO:0090084)7.74275797
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.63196488
11single fertilization (GO:0007338)7.21406726
12sperm capacitation (GO:0048240)7.00709568
13spermatogenesis (GO:0007283)6.82783137
14male gamete generation (GO:0048232)6.80031461
15organic cation transport (GO:0015695)6.70937654
16piRNA metabolic process (GO:0034587)6.44069060
17synaptonemal complex organization (GO:0070193)6.43597535
18synaptonemal complex assembly (GO:0007130)6.31417123
19regulation of inclusion body assembly (GO:0090083)6.25805744
20male meiosis (GO:0007140)6.23731746
21gamete generation (GO:0007276)6.23661961
22fertilization (GO:0009566)6.19214308
23microtubule depolymerization (GO:0007019)6.06316112
24microtubule severing (GO:0051013)5.76533065
25chromosome condensation (GO:0030261)5.67873222
26regulation of microtubule-based movement (GO:0060632)5.48871016
27DNA packaging (GO:0006323)5.39895809
28calcium ion-dependent exocytosis (GO:0017156)5.34204664
29germ cell development (GO:0007281)5.29951334
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.21363762
31ventricular system development (GO:0021591)5.00019359
32glycerol ether metabolic process (GO:0006662)4.96638233
33multicellular organismal reproductive process (GO:0048609)4.92697003
34cell recognition (GO:0008037)4.91982925
35pyrimidine nucleoside salvage (GO:0043097)4.89243803
36pyrimidine-containing compound salvage (GO:0008655)4.89243803
37diaphragm development (GO:0060539)4.85102281
38spermatid nucleus differentiation (GO:0007289)4.64086227
39ether metabolic process (GO:0018904)4.56655900
40seminiferous tubule development (GO:0072520)4.49299741
413-UTR-mediated mRNA stabilization (GO:0070935)4.47421085
42left/right pattern formation (GO:0060972)4.46456420
43male meiosis I (GO:0007141)4.45572993
44response to peptidoglycan (GO:0032494)4.33628427
45interferon-gamma secretion (GO:0072643)4.30918862
46protein polyglutamylation (GO:0018095)4.20025666
47skeletal muscle organ development (GO:0060538)4.15396818
48chromosome organization involved in meiosis (GO:0070192)4.13800502
49negative regulation of erythrocyte differentiation (GO:0045647)4.12476180
50negative regulation of granulocyte differentiation (GO:0030853)4.10880111
51protein localization to cilium (GO:0061512)4.07406101
52sexual reproduction (GO:0019953)4.07402449
53DNA methylation involved in gamete generation (GO:0043046)4.07025811
54activation of MAPKKK activity (GO:0000185)4.05551722
55multicellular organismal development (GO:0007275)3.97982374
56chaperone-mediated protein complex assembly (GO:0051131)3.96025140
57single strand break repair (GO:0000012)3.90093309
58positive regulation of cell size (GO:0045793)3.87244147
59sequestering of actin monomers (GO:0042989)3.84161313
60protein localization to endosome (GO:0036010)3.78430382
61cellular protein complex localization (GO:0034629)3.72896384
62meiotic nuclear division (GO:0007126)3.70761673
63meiosis I (GO:0007127)3.52821932
64modulation by symbiont of host defense response (GO:0052031)3.51201344
65modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51201344
66modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51201344
67positive regulation by organism of defense response of other organism involved in symbiotic interact3.51201344
68modulation by symbiont of host immune response (GO:0052553)3.51201344
69positive regulation by symbiont of host defense response (GO:0052509)3.51201344
70nucleotide salvage (GO:0043173)3.49997132
71protein refolding (GO:0042026)3.47409466
72natural killer cell mediated cytotoxicity (GO:0042267)3.46459114
73natural killer cell mediated immunity (GO:0002228)3.46459114
74negative regulation of cell size (GO:0045792)3.43690846
75RNA destabilization (GO:0050779)3.42257015
76lipopolysaccharide-mediated signaling pathway (GO:0031663)3.25769220
77negative regulation of interleukin-12 production (GO:0032695)3.25063252
78genitalia morphogenesis (GO:0035112)3.21936184
79regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.21781365
80regulation of spindle checkpoint (GO:0090231)3.20661892
81response to lipoprotein particle (GO:0055094)3.19072427
82membrane protein intracellular domain proteolysis (GO:0031293)3.13604602
83regulation of cholesterol biosynthetic process (GO:0045540)3.12495423
84pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)3.06606048
85UMP biosynthetic process (GO:0006222)3.06606048
86pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)3.06606048
87UMP metabolic process (GO:0046049)3.06606048
88hypotonic response (GO:0006971)3.04527889
89monoubiquitinated protein deubiquitination (GO:0035520)3.04369400
90NIK/NF-kappaB signaling (GO:0038061)3.03165919
91sensory perception of smell (GO:0007608)3.02850295
92nucleoside diphosphate phosphorylation (GO:0006165)3.02785913
93nucleus organization (GO:0006997)3.01792030
94RNA localization (GO:0006403)2.99503308
95regulation of mast cell degranulation (GO:0043304)2.99377546
96modulation by symbiont of host cellular process (GO:0044068)2.97857175
97neutrophil activation involved in immune response (GO:0002283)2.97362505
98glycolytic process (GO:0006096)2.96112461
99meiotic cell cycle (GO:0051321)2.96080158
100pinocytosis (GO:0006907)2.95790565
101amino-acid betaine transport (GO:0015838)2.94933873
102carnitine transport (GO:0015879)2.94933873
103positive regulation of macrophage activation (GO:0043032)2.94901966
104macrophage activation involved in immune response (GO:0002281)2.94846162
105polyamine biosynthetic process (GO:0006596)2.94551375
106regulation of monocyte differentiation (GO:0045655)2.94285677
107negative regulation of vascular permeability (GO:0043116)2.93687375
108RNA stabilization (GO:0043489)2.93413203
109mRNA stabilization (GO:0048255)2.93413203
110negative regulation of interleukin-2 production (GO:0032703)2.93356318
111negative regulation of calcium ion transport into cytosol (GO:0010523)2.93217622
112positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.92826081
113arginine catabolic process (GO:0006527)2.91679252
114positive regulation of gamma-delta T cell activation (GO:0046645)2.89686047
115protein K11-linked deubiquitination (GO:0035871)2.89210338
116cellular response to thyroid hormone stimulus (GO:0097067)2.86588153
117microtubule polymerization or depolymerization (GO:0031109)2.85350708
118positive regulation of receptor biosynthetic process (GO:0010870)2.84720575
119regulation of leukocyte degranulation (GO:0043300)2.83621769
120modulation by virus of host process (GO:0019054)2.82379785
121regulation of cilium assembly (GO:1902017)2.82010273
122mitotic sister chromatid cohesion (GO:0007064)2.81396903
123protein insertion into membrane (GO:0051205)2.81349386
124cilium morphogenesis (GO:0060271)2.81087392
125response to laminar fluid shear stress (GO:0034616)2.79300708
126negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.79036686
127regulation of mast cell activation involved in immune response (GO:0033006)2.78216093
128positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.76981069
129mannose metabolic process (GO:0006013)2.76862883
130polyol catabolic process (GO:0046174)2.76580371
131chromatin silencing (GO:0006342)2.76503924
132carnitine transmembrane transport (GO:1902603)2.76392368
133axoneme assembly (GO:0035082)2.76006065
134response to muramyl dipeptide (GO:0032495)2.75127248
135peptidyl-glutamic acid modification (GO:0018200)2.74768324
136positive regulation of histone acetylation (GO:0035066)2.74188785
137detection of other organism (GO:0098543)2.73011614
138nucleoside salvage (GO:0043174)2.72588235
139cellular response to nerve growth factor stimulus (GO:1990090)2.72207197
140response to nerve growth factor (GO:1990089)2.72207197
141low-density lipoprotein particle clearance (GO:0034383)2.71553233
142dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.70472969
143detection of bacterium (GO:0016045)2.69215857
144pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.68766063
145germinal center formation (GO:0002467)2.67003125
146negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66574323
147negative regulation of cell killing (GO:0031342)2.66574323
148GTP biosynthetic process (GO:0006183)2.65335778
149cilium organization (GO:0044782)2.64871591
150regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63785942
151retrograde transport, endosome to Golgi (GO:0042147)2.62673401
152response to thyroid hormone (GO:0097066)2.60813854
153negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.60803267
154cilium assembly (GO:0042384)2.57015163
155epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56526894
156alditol metabolic process (GO:0019400)2.55634585
157regulation of cholesterol storage (GO:0010885)2.55608730
158amino sugar catabolic process (GO:0046348)2.53696366
159glycosphingolipid catabolic process (GO:0046479)2.53323929
160microtubule-based movement (GO:0007018)2.53284231
161phagosome maturation (GO:0090382)2.52236674
162negative regulation of cytokine production involved in immune response (GO:0002719)2.51906569
163response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.51802406
164response to host immune response (GO:0052572)2.51802406
165cellular component assembly involved in morphogenesis (GO:0010927)2.51097970
166positive regulation of glycolytic process (GO:0045821)2.49463131
167mitochondrion degradation (GO:0000422)2.49305903
168regulation of cell size (GO:0008361)2.48986837
169immunoglobulin mediated immune response (GO:0016064)2.47498371
170regulation of type I interferon-mediated signaling pathway (GO:0060338)2.47383868
171urea cycle (GO:0000050)2.47323969
172myeloid dendritic cell differentiation (GO:0043011)2.47146409
173positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.46389342
174lactate metabolic process (GO:0006089)2.45551108
175detection of external biotic stimulus (GO:0098581)2.44966700
176pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.44826860
177response to host (GO:0075136)2.44599914
178response to host defenses (GO:0052200)2.44599914
179response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.44599914
180leukocyte aggregation (GO:0070486)2.44281005
181positive regulation of Cdc42 GTPase activity (GO:0043089)2.43341085
182positive regulation of protein acetylation (GO:1901985)2.43063624
183positive regulation of peptidyl-lysine acetylation (GO:2000758)2.43063624
184regulation of interferon-beta biosynthetic process (GO:0045357)2.41785149
185detection of molecule of bacterial origin (GO:0032490)2.36069835
186negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.35016297
187apoptotic process involved in morphogenesis (GO:0060561)2.34171309
188negative regulation of alcohol biosynthetic process (GO:1902931)2.33982095
189Rap protein signal transduction (GO:0032486)2.32586516
190sperm motility (GO:0030317)14.0323269
191acrosome reaction (GO:0007340)12.2659614
192fusion of sperm to egg plasma membrane (GO:0007342)12.1290921
193cell wall macromolecule catabolic process (GO:0016998)11.5386261
194cell wall macromolecule metabolic process (GO:0044036)11.5386261
195sperm-egg recognition (GO:0035036)11.2941173
196acrosome assembly (GO:0001675)10.8263579
197binding of sperm to zona pellucida (GO:0007339)10.2999668
198cell-cell recognition (GO:0009988)10.1914641
199axonemal dynein complex assembly (GO:0070286)10.1659140
200multicellular organism reproduction (GO:0032504)10.0460114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.15377779
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.62496980
3EZH2_22144423_ChIP-Seq_EOC_Human3.83750938
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.68931041
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40555848
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.30348654
7VDR_21846776_ChIP-Seq_THP-1_Human3.14168343
8MYC_22102868_ChIP-Seq_BL_Human2.92011825
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.85773942
10LXR_22292898_ChIP-Seq_THP-1_Human2.77064468
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.70362613
12ELK3_25401928_ChIP-Seq_HUVEC_Human2.58114569
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.40267552
14VDR_22108803_ChIP-Seq_LS180_Human2.39168348
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24355615
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21279187
17CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21096085
18EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.20638139
19KDM2B_26808549_Chip-Seq_DND41_Human2.19637934
20TCF7_22412390_ChIP-Seq_EML_Mouse2.16846040
21TP63_17297297_ChIP-ChIP_HaCaT_Human2.11763493
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11504234
23SCL_19346495_ChIP-Seq_HPC-7_Human2.09577852
24VDR_24763502_ChIP-Seq_THP-1_Human2.04508451
25RACK7_27058665_Chip-Seq_MCF-7_Human1.99963369
26FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97876080
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95314735
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.83095854
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.82584479
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80109782
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.79655363
32MAF_26560356_Chip-Seq_TH1_Human1.79001432
33ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77860584
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.74833592
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74618398
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70944293
37KDM2B_26808549_Chip-Seq_K562_Human1.70841211
38STAT1_17558387_ChIP-Seq_HELA_Human1.68809085
39KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67015886
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66204427
41SOX2_22085726_ChIP-Seq_NPCs_Mouse1.63239199
42MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62486628
43KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.61967297
44P68_20966046_ChIP-Seq_HELA_Human1.61241509
45FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.61229408
46SMC4_20622854_ChIP-Seq_HELA_Human1.59827709
47TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.58325071
48GATA3_21867929_ChIP-Seq_CD8_Mouse1.57851412
49IRF8_21731497_ChIP-ChIP_J774_Mouse1.57829305
50PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.55234762
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.55217162
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.53765500
53PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53243626
54ESR2_21235772_ChIP-Seq_MCF-7_Human1.52807448
55TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52665626
56MYB_21317192_ChIP-Seq_ERMYB_Mouse1.52068580
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51901967
58UTX_26944678_Chip-Seq_JUKART_Human1.50904812
59RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50417001
60ZNF263_19887448_ChIP-Seq_K562_Human1.50162019
61FLI1_27457419_Chip-Seq_LIVER_Mouse1.49849622
62MAF_26560356_Chip-Seq_TH2_Human1.46122844
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.45088365
64SA1_27219007_Chip-Seq_ERYTHROID_Human1.45047576
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43836357
66CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43778686
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.42667563
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.41683854
69GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.41082178
70ZNF274_21170338_ChIP-Seq_K562_Hela1.41017382
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.40797927
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.40661827
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.39373818
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.36424540
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35480053
76IRF8_27001747_Chip-Seq_BMDM_Mouse1.35103681
77NCOR1_26117541_ChIP-Seq_K562_Human1.35037648
78GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34997433
79SPI1_23127762_ChIP-Seq_K562_Human1.34978864
80P53_21459846_ChIP-Seq_SAOS-2_Human1.34771958
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34102776
82GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34048811
83SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33444562
84SPI1_26923725_Chip-Seq_HPCs_Mouse1.32861084
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.32194825
86BP1_19119308_ChIP-ChIP_Hs578T_Human1.31821935
87CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31290084
88RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30644650
89* SPI1_23547873_ChIP-Seq_NB4_Human1.30364744
90PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29755041
91MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29296936
92SRY_22984422_ChIP-ChIP_TESTIS_Rat1.29057788
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27769037
94ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27448804
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27050283
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.27050283
97EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.27041485
98RXRA_24833708_ChIP-Seq_LIVER_Mouse1.26237253
99VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26078417
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25683775
101TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25466081
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25376799
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23883102
104RAD21_21589869_ChIP-Seq_MESCs_Mouse1.23282873
105RUNX1_27514584_Chip-Seq_MCF-7_Human1.23254657
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22755172
107CBP_20019798_ChIP-Seq_JUKART_Human1.22755172
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.22160198
109TFEB_21752829_ChIP-Seq_HELA_Human1.21958558
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21727219
111GF1_26923725_Chip-Seq_HPCs_Mouse1.20944257
112BCOR_27268052_Chip-Seq_Bcells_Human1.20405333
113CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20073506
114GATA1_19941826_ChIP-Seq_K562_Human1.19976867
115STAT4_19710469_ChIP-ChIP_TH1__Mouse1.19947447
116RUNX1_26923725_Chip-Seq_HPCs_Mouse1.19923869
117SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19177702
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18261860
119TET1_21451524_ChIP-Seq_MESCs_Mouse1.17342904
120TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16311518
121GATA1_19941827_ChIP-Seq_MEL86_Mouse1.15912914
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.15885999
123MYC_27129775_Chip-Seq_CORNEA_Mouse1.15726980
124ELF1_20517297_ChIP-Seq_JURKAT_Human1.14162299
125ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13822544
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.13474447
127ERG_20517297_ChIP-Seq_VCAP_Human1.13094910
128KDM2B_26808549_Chip-Seq_REH_Human1.12938087
129STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12879036
130CTCF_20526341_ChIP-Seq_ESCs_Human1.12550233
131GATA3_21867929_ChIP-Seq_TH1_Mouse1.12410040
132KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12237137
133SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12078900
134JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11812964
135SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11573761
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11268171
137REST_21632747_ChIP-Seq_MESCs_Mouse1.11132808
138KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10962972
139TP53_22127205_ChIP-Seq_IMR90_Human1.10239867
140CREB1_26743006_Chip-Seq_LNCaP_Human1.08969372
141RUNX_20019798_ChIP-Seq_JUKART_Human1.08390540
142UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.08197495
143PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07514278
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07043067
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06259073
146ERG_21242973_ChIP-ChIP_JURKAT_Human1.06235867
147SOX11_22085726_ChIP-Seq_ESNs_Mouse1.06231813
148RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06121427
149P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05814155
150ATF3_27146783_Chip-Seq_COLON_Human1.05743969
151FLI1_21867929_ChIP-Seq_TH2_Mouse1.05066534
152TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04422765
153TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02871359
154PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01783406
155ESET_19884257_ChIP-Seq_ESCs_Mouse1.01447128
156PHF8_20622854_ChIP-Seq_HELA_Human1.00492731
157RARA_24833708_ChIP-Seq_LIVER_Mouse1.00106869
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99559573
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98524296
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.98501939
161PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98135756
162YY1_22570637_ChIP-Seq_MALME-3M_Human0.97178037
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97002269
164RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96299318
165RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95965201
166PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95669616
167BCL6_27268052_Chip-Seq_Bcells_Human0.94878957
168ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94394576
169LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92881534
170NFE2_27457419_Chip-Seq_LIVER_Mouse0.90957135
171MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.90865655
172CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90674268
173CTCF_26484167_Chip-Seq_Bcells_Mouse0.88951843
174SMC3_22415368_ChIP-Seq_MEFs_Mouse0.88888893
175TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88218127
176NFYB_21822215_ChIP-Seq_K562_Human0.87915209
177NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87630906
178KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.86317605
179SOX2_21211035_ChIP-Seq_LN229_Human0.86141328
180RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.85708396
181FLI1_21867929_ChIP-Seq_CD8_Mouse0.85378199
182EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.85050828
183SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85009116
184CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.84468869
185LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.84113258
186SMAD3_21741376_ChIP-Seq_ESCs_Human0.83879487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.62940385
2MP0001929_abnormal_gametogenesis5.06274514
3MP0005058_abnormal_lysosome_morphology3.85753151
4MP0005670_abnormal_white_adipose3.36889319
5MP0003303_peritoneal_inflammation3.31356778
6MP0008877_abnormal_DNA_methylation3.28655070
7MP0001984_abnormal_olfaction3.20738813
8MP0004858_abnormal_nervous_system3.16133570
9MP0002161_abnormal_fertility/fecundity3.06207490
10MP0002210_abnormal_sex_determination2.98607493
11MP0000566_synostosis2.76960695
12MP0005451_abnormal_body_composition2.69754332
13MP0005076_abnormal_cell_differentiation2.65425845
14MP0001145_abnormal_male_reproductive2.49628895
15MP0009840_abnormal_foam_cell2.35877980
16MP0005167_abnormal_blood-brain_barrier2.34219144
17MP0003172_abnormal_lysosome_physiology2.27099695
18MP0000653_abnormal_sex_gland2.13206280
19MP0003191_abnormal_cellular_cholesterol2.05342016
20MP0008260_abnormal_autophagy2.03250876
21MP0000858_altered_metastatic_potential2.01829997
22MP0005410_abnormal_fertilization16.3518413
23MP0002653_abnormal_ependyma_morphology1.89739941
24MP0002419_abnormal_innate_immunity1.88303125
25MP0003300_gastrointestinal_ulcer1.85961069
26MP0003075_altered_response_to1.70173179
27MP0002148_abnormal_hypersensitivity_rea1.68868161
28MP0005025_abnormal_response_to1.67706100
29MP0003763_abnormal_thymus_physiology1.62858256
30MP0004947_skin_inflammation1.60893300
31MP0001533_abnormal_skeleton_physiology1.59816636
32MP0002254_reproductive_system_inflammat1.56400187
33MP0002160_abnormal_reproductive_system1.53302118
34MP0009764_decreased_sensitivity_to1.43992791
35MP0003724_increased_susceptibility_to1.43059565
36MP0003566_abnormal_cell_adhesion1.41077553
37MP0002998_abnormal_bone_remodeling1.40716800
38MP0002396_abnormal_hematopoietic_system1.39806498
39MP0001835_abnormal_antigen_presentation1.39741257
40MP0003453_abnormal_keratinocyte_physiol1.38212217
41MP0005623_abnormal_meninges_morphology1.37874198
42MP0000490_abnormal_crypts_of1.37359939
43MP0009785_altered_susceptibility_to1.35526435
44MP0005464_abnormal_platelet_physiology1.34199234
45MP0009053_abnormal_anal_canal1.33575704
46MP0003646_muscle_fatigue1.33416109
47MP0009333_abnormal_splenocyte_physiolog1.32453493
48MP0005671_abnormal_response_to1.29872134
49MP0004233_abnormal_muscle_weight1.27948424
50MP0000343_altered_response_to1.26952920
51MP0004043_abnormal_pH_regulation1.26761123
52MP0010368_abnormal_lymphatic_system1.24566159
53MP0004185_abnormal_adipocyte_glucose1.23969456
54MP0010307_abnormal_tumor_latency1.21869786
55MP0001845_abnormal_inflammatory_respons1.21311426
56MP0002138_abnormal_hepatobiliary_system1.20684018
57MP0000767_abnormal_smooth_muscle1.16815612
58MP0003279_aneurysm1.16400638
59MP0001853_heart_inflammation1.15514201
60MP0003448_altered_tumor_morphology1.12789597
61MP0000569_abnormal_digit_pigmentation1.12156994
62MP0010234_abnormal_vibrissa_follicle1.09242313
63MP0010155_abnormal_intestine_physiology1.07148630
64MP0001765_abnormal_ion_homeostasis1.06467375
65MP0002282_abnormal_trachea_morphology1.04494230
66MP0000467_abnormal_esophagus_morphology1.04117392
67MP0003091_abnormal_cell_migration1.03814150
68MP0000716_abnormal_immune_system1.03468845
69MP0001348_abnormal_lacrimal_gland1.02485214
70MP0008469_abnormal_protein_level1.01695271
71MP0005166_decreased_susceptibility_to1.00551175
72MP0003828_pulmonary_edema0.99492844
73MP0002429_abnormal_blood_cell0.95913345
74MP0004147_increased_porphyrin_level0.94666277
75MP0000685_abnormal_immune_system0.94275469
76MP0004883_abnormal_blood_vessel0.94238262
77MP0004510_myositis0.90362902
78MP0003806_abnormal_nucleotide_metabolis0.90095645
79MP0005390_skeleton_phenotype0.89324623
80MP0000689_abnormal_spleen_morphology0.88750464
81MP0002132_abnormal_respiratory_system0.87689244
82MP0002722_abnormal_immune_system0.86405745
83MP0001663_abnormal_digestive_system0.86121171
84MP0000465_gastrointestinal_hemorrhage0.85093915
85MP0006082_CNS_inflammation0.83945699
86MP0005647_abnormal_sex_gland0.77640207
87MP0005164_abnormal_response_to0.76063054
88MP0005666_abnormal_adipose_tissue0.71859701
89MP0008874_decreased_physiological_sensi0.71491843
90MP0000750_abnormal_muscle_regeneration0.71397537
91MP0002113_abnormal_skeleton_development0.71237129
92MP0002928_abnormal_bile_duct0.69277255
93MP0001873_stomach_inflammation0.69259882
94MP0000470_abnormal_stomach_morphology0.68795854
95MP0002139_abnormal_hepatobiliary_system0.68556544
96MP0000609_abnormal_liver_physiology0.67911904
97MP0001293_anophthalmia0.67896283
98MP0009278_abnormal_bone_marrow0.66873494
99MP0000703_abnormal_thymus_morphology0.66448501
100MP0003115_abnormal_respiratory_system0.66238570
101MP0002796_impaired_skin_barrier0.65355043
102MP0001664_abnormal_digestion0.65308567
103MP0001545_abnormal_hematopoietic_system0.59861076
104MP0005397_hematopoietic_system_phenotyp0.59861076
105MP0005389_reproductive_system_phenotype0.59198021
106MP0002234_abnormal_pharynx_morphology0.56057489
107MP0002295_abnormal_pulmonary_circulatio0.56047540
108MP0009046_muscle_twitch0.53952367
109MP0005377_hearing/vestibular/ear_phenot0.52419691
110MP0003878_abnormal_ear_physiology0.52419691
111MP0002405_respiratory_system_inflammati0.50102175
112MP0008995_early_reproductive_senescence0.48571995
113MP0004133_heterotaxia0.46842219
114MP0008058_abnormal_DNA_repair0.45231340
115MP0000358_abnormal_cell_content/0.44917934
116MP0001764_abnormal_homeostasis0.44481242
117MP0005636_abnormal_mineral_homeostasis0.44365078
118MP0003045_fibrosis0.43365398
119MP0000604_amyloidosis0.41756414
120MP0001324_abnormal_eye_pigmentation0.39768838
121MP0002269_muscular_atrophy0.39428374
122MP0009115_abnormal_fat_cell0.38326308
123MP0002971_abnormal_brown_adipose0.37338010
124MP0003699_abnormal_female_reproductive0.33607862
125MP0005375_adipose_tissue_phenotype0.33423737
126MP0004036_abnormal_muscle_relaxation0.32944605
127MP0002092_abnormal_eye_morphology0.30688860
128MP0008770_decreased_survivor_rate0.30466455
129MP0003329_amyloid_beta_deposits0.30141297
130MP0002877_abnormal_melanocyte_morpholog0.30054773
131MP0005387_immune_system_phenotype0.29702100
132MP0001790_abnormal_immune_system0.29702100
133MP0002452_abnormal_antigen_presenting0.26892074
134MP0002723_abnormal_immune_serum0.25516298
135MP0002009_preneoplasia0.24638851
136MP0002166_altered_tumor_susceptibility0.24094368
137MP0002169_no_abnormal_phenotype0.23390322
138MP0003948_abnormal_gas_homeostasis0.23295142
139MP0002873_normal_phenotype0.22995632
140MP0002693_abnormal_pancreas_physiology0.22743090
141MP0001819_abnormal_immune_cell0.22104400
142MP0000733_abnormal_muscle_development0.21255896
143MP0001800_abnormal_humoral_immune0.21232092
144MP0003959_abnormal_lean_body0.21064813
145MP0008007_abnormal_cellular_replicative0.20787780
146MP0004811_abnormal_neuron_physiology0.20586431
147MP0005391_vision/eye_phenotype0.19889243
148MP0000534_abnormal_ureter_morphology0.18276793
149MP0001849_ear_inflammation0.17541223
150MP0003252_abnormal_bile_duct0.17326819
151MP0002420_abnormal_adaptive_immunity0.17079571
152MP0003942_abnormal_urinary_system0.17067796
153MP0005584_abnormal_enzyme/coenzyme_acti0.16441435
154MP0003436_decreased_susceptibility_to0.16185408
155MP0008872_abnormal_physiological_respon0.15675179
156MP0002398_abnormal_bone_marrow0.15404792
157MP0003786_premature_aging0.14658746
158MP0002152_abnormal_brain_morphology0.14582090
159MP0003936_abnormal_reproductive_system0.14353468
160MP0005310_abnormal_salivary_gland0.14326943
161MP0003011_delayed_dark_adaptation0.14207816
162MP0006036_abnormal_mitochondrial_physio0.14031920
163MP0002106_abnormal_muscle_physiology0.13983992
164MP0000249_abnormal_blood_vessel0.13931970
165MP0010630_abnormal_cardiac_muscle0.13863529
166MP0004808_abnormal_hematopoietic_stem0.13852412
167MP0003705_abnormal_hypodermis_morpholog0.13784763
168MP0005000_abnormal_immune_tolerance0.13575274

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.06690604
2Abnormal respiratory epithelium morphology (HP:0012253)8.84012752
3Abnormal respiratory motile cilium morphology (HP:0005938)8.84012752
4Chronic bronchitis (HP:0004469)7.57605690
5Rhinitis (HP:0012384)7.37223330
6Nasal polyposis (HP:0100582)7.08388827
7Abnormal ciliary motility (HP:0012262)6.61555052
8Infertility (HP:0000789)6.50933512
9Abnormality of the nasal mucosa (HP:0000433)5.80302732
10Autoimmune thrombocytopenia (HP:0001973)5.18361496
11Bronchitis (HP:0012387)4.77210205
12Dysostosis multiplex (HP:0000943)4.65291773
13Male infertility (HP:0003251)4.54075067
14Bronchiectasis (HP:0002110)4.52287598
15Abnormal spermatogenesis (HP:0008669)4.49017238
16Sparse lateral eyebrow (HP:0005338)4.40420012
17Abnormality of mucopolysaccharide metabolism (HP:0011020)4.10381145
18Abnormality of polysaccharide metabolism (HP:0011012)4.10381145
19Abnormality of glycosaminoglycan metabolism (HP:0004371)4.10381145
20Mucopolysacchariduria (HP:0008155)4.06124006
21Urinary glycosaminoglycan excretion (HP:0003541)4.06124006
22Abnormality of glycolipid metabolism (HP:0010969)3.97243792
23Abnormality of liposaccharide metabolism (HP:0010968)3.97243792
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.97243792
25Nephronophthisis (HP:0000090)3.80894377
26Abnormality of the fingertips (HP:0001211)3.78141056
27Lip pit (HP:0100267)3.48039242
28Recurrent otitis media (HP:0000403)3.47832218
29Azoospermia (HP:0000027)3.42090789
30Increased cerebral lipofuscin (HP:0011813)3.37524300
31Recurrent sinusitis (HP:0011108)3.33041915
32Eczematoid dermatitis (HP:0000976)3.32605000
33Anal stenosis (HP:0002025)3.25281627
34Abnormality of macrophages (HP:0004311)3.21332344
35Ureteral stenosis (HP:0000071)3.15072007
36Loss of speech (HP:0002371)2.94878147
37Ureteral obstruction (HP:0006000)2.93723909
38Long palpebral fissure (HP:0000637)2.90945026
39Recurrent bronchitis (HP:0002837)2.90279883
40Abnormality of the renal medulla (HP:0100957)2.87634311
41Increased neuronal autofluorescent lipopigment (HP:0002074)2.86149795
42Abnormality of the distal phalanges of the toes (HP:0010182)2.82889964
43Recurrent abscess formation (HP:0002722)2.82314483
44Intestinal fistula (HP:0100819)2.78049324
45Fatigue (HP:0012378)2.71249221
46Impulsivity (HP:0100710)2.66742993
47Natal tooth (HP:0000695)2.66648023
48Recurrent bacterial skin infections (HP:0005406)2.66488795
49Tubulointerstitial nephritis (HP:0001970)2.54758785
50Dyschromatopsia (HP:0007641)2.53887155
51Choroideremia (HP:0001139)2.51171726
52Broad face (HP:0000283)2.49459857
53Hypertensive crisis (HP:0100735)2.45387154
54Progressive neurologic deterioration (HP:0002344)2.45053884
55Testicular atrophy (HP:0000029)2.43363563
56Depressed nasal tip (HP:0000437)2.40350887
57Abnormal gallbladder physiology (HP:0012438)2.38433626
58Cholecystitis (HP:0001082)2.38433626
59Vacuolated lymphocytes (HP:0001922)2.36825674
60Short 5th finger (HP:0009237)2.35857297
61Abnormality of midbrain morphology (HP:0002418)2.35576349
62Molar tooth sign on MRI (HP:0002419)2.35576349
63Lower limb hyperreflexia (HP:0002395)2.35037302
64Increased serum ferritin (HP:0003281)2.32652250
65Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32311229
66Thoracic kyphosis (HP:0002942)2.29936741
67Axonal loss (HP:0003447)2.26995551
68Hyperacusis (HP:0010780)2.24618263
69Cellulitis (HP:0100658)2.24097144
70Retinal dysplasia (HP:0007973)2.22171390
71Tubular atrophy (HP:0000092)2.21760349
72Distal lower limb amyotrophy (HP:0008944)2.18087955
73Increased CSF protein (HP:0002922)2.17978565
74Heterotopia (HP:0002282)2.17912988
75Tubulointerstitial abnormality (HP:0001969)2.17249000
76Obstructive lung disease (HP:0006536)2.16951494
77Chronic obstructive pulmonary disease (HP:0006510)2.16951494
78Bell-shaped thorax (HP:0001591)2.15187227
79Abnormality of the periventricular white matter (HP:0002518)2.13592707
80Vertebral compression fractures (HP:0002953)2.12521814
81Obstructive sleep apnea (HP:0002870)2.12332525
82Myositis (HP:0100614)2.11662309
83Recurrent gram-negative bacterial infections (HP:0005420)2.09778208
84Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09647632
85Abnormality of the thoracic spine (HP:0100711)2.09204531
86Purpura (HP:0000979)2.07720924
87Systemic lupus erythematosus (HP:0002725)2.06170428
88Mediastinal lymphadenopathy (HP:0100721)2.05535182
89Gingivitis (HP:0000230)2.03389350
90Polycythemia (HP:0001901)2.02821217
91Gonadotropin excess (HP:0000837)2.00118277
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4026960
93Absent/shortened dynein arms (HP:0200106)12.6810406
94Dynein arm defect of respiratory motile cilia (HP:0012255)12.6810406
95Trismus (HP:0000211)1.99001164
96Nuclear cataract (HP:0100018)1.98264574
97Thin bony cortex (HP:0002753)1.98125121
98Asymmetry of the thorax (HP:0001555)1.97960482
99Distal lower limb muscle weakness (HP:0009053)1.97641349
100Achilles tendon contracture (HP:0001771)1.96855738
101Myocardial infarction (HP:0001658)1.94007338
102Abnormality of iron homeostasis (HP:0011031)1.91258123
103Petechiae (HP:0000967)1.90432388
104Disproportionate tall stature (HP:0001519)1.87240204
105Spastic tetraparesis (HP:0001285)1.86715000
106Centrally nucleated skeletal muscle fibers (HP:0003687)1.86625821
107Abnormality of transition element cation homeostasis (HP:0011030)1.86146629
108Emphysema (HP:0002097)1.85754911
109Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.85437249
110Vertebral hypoplasia (HP:0008417)1.85437249
111Neuronal loss in central nervous system (HP:0002529)1.84684253
112Hypertriglyceridemia (HP:0002155)1.84400047
113Increased IgE level (HP:0003212)1.84223751
114Advanced eruption of teeth (HP:0006288)1.82117314
115Tubulointerstitial fibrosis (HP:0005576)1.81871786
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.81571471
117Renal cell carcinoma (HP:0005584)1.81260429
118Peripheral demyelination (HP:0011096)1.80661537
119Increased connective tissue (HP:0009025)1.80294224
120Neonatal death (HP:0003811)1.78799413
121J-shaped sella turcica (HP:0002680)1.78643637
122Deep venous thrombosis (HP:0002625)1.78352294
123Hemorrhage of the eye (HP:0011885)1.77124377
124Colitis (HP:0002583)1.75498644
125Blue sclerae (HP:0000592)1.73595614
126Abnormality of the Achilles tendon (HP:0005109)1.72650319
127Recurrent fungal infections (HP:0002841)1.70604540
128Abnormal glucose tolerance (HP:0001952)1.67541368
129Interstitial pulmonary disease (HP:0006530)1.67365307
130Cerebral aneurysm (HP:0004944)1.66839526
131Gastrointestinal inflammation (HP:0004386)1.66274326
132Prolonged bleeding time (HP:0003010)1.64929618
133Bone pain (HP:0002653)1.64702541
134Flat acetabular roof (HP:0003180)1.64649202
135Medial flaring of the eyebrow (HP:0010747)1.63304544
136Recurrent viral infections (HP:0004429)1.62581166
137Recurrent skin infections (HP:0001581)1.62557851
138Meningitis (HP:0001287)1.62446794
139Asymmetric septal hypertrophy (HP:0001670)1.62120088
140Popliteal pterygium (HP:0009756)1.61199784
141Short nail (HP:0001799)1.60640946
142Abnormality of dentin (HP:0010299)1.58089666
143Bundle branch block (HP:0011710)1.55173858
144Retrobulbar optic neuritis (HP:0100654)1.54735458
145Optic neuritis (HP:0100653)1.54735458
146Oculomotor apraxia (HP:0000657)1.52746857
147Decreased central vision (HP:0007663)1.52580094
148Stage 5 chronic kidney disease (HP:0003774)1.51487628
149Double outlet right ventricle (HP:0001719)1.50195182
150Congenital malformation of the right heart (HP:0011723)1.50195182
151Exercise-induced myalgia (HP:0003738)1.48219699
152Abnormal biliary tract physiology (HP:0012439)1.48211312
153Bile duct proliferation (HP:0001408)1.48211312
154Easy fatigability (HP:0003388)1.47282249
155Congenital hepatic fibrosis (HP:0002612)1.40734187
156Deformed sella turcica (HP:0002681)1.40546774
157Cerebellar dysplasia (HP:0007033)1.38990900
158Cerebral palsy (HP:0100021)1.38669135
159Postaxial foot polydactyly (HP:0001830)1.37750604
160Personality changes (HP:0000751)1.35687593
161Chronic sinusitis (HP:0011109)1.35450747
162Neurofibrillary tangles (HP:0002185)1.35291858
163Bony spicule pigmentary retinopathy (HP:0007737)1.34833423
164Aplasia/Hypoplasia of the lens (HP:0008063)1.34365214
165Short ribs (HP:0000773)1.33339523
166Hypoplasia of the capital femoral epiphysis (HP:0003090)1.32534046
167Neoplasm of the heart (HP:0100544)1.32223641
168Hypercholesterolemia (HP:0003124)1.31963829
169Global brain atrophy (HP:0002283)1.31872083
170Abnormality of complement system (HP:0005339)1.31141282
171Hyporeflexia of lower limbs (HP:0002600)1.29973217
172Fatigable weakness (HP:0003473)1.29719431
173Abnormality of the neuromuscular junction (HP:0003398)1.29719431
174Abnormality of the renal cortex (HP:0011035)1.29529777
175Abnormality of renal excretion (HP:0011036)1.27566132
176Abnormal drinking behavior (HP:0030082)1.26812852
177Polydipsia (HP:0001959)1.26812852
178Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.25482395
179Abnormality of permanent molar morphology (HP:0011071)1.24279288
180Abnormality of the dental root (HP:0006486)1.24279288
181Taurodontia (HP:0000679)1.24279288
182Orchitis (HP:0100796)1.23192627
183Abnormal ventriculo-arterial connection (HP:0011563)1.22767474
184Transposition of the great arteries (HP:0001669)1.22767474
185Abnormal connection of the cardiac segments (HP:0011545)1.22767474
186Short thorax (HP:0010306)1.21760705
187Myoglobinuria (HP:0002913)1.21366662
188Postaxial hand polydactyly (HP:0001162)1.20110926
189Disinhibition (HP:0000734)1.19852728
190Constricted visual fields (HP:0001133)1.19418222
191Type II lissencephaly (HP:0007260)1.18775708
192Cystic liver disease (HP:0006706)1.17158924
193Macular degeneration (HP:0000608)1.16737701
194Nephropathy (HP:0000112)1.15805831
195Abnormality of molar (HP:0011077)1.15090127
196Abnormality of molar morphology (HP:0011070)1.15090127

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.40427507
2PDK46.65681359
3PDK36.65681359
4PRKD36.16798852
5ICK5.65756984
6PDK24.17726851
7STK243.84475581
8IRAK33.82096254
9MAP3K33.39318556
10PRPF4B2.80011014
11ERN12.55364326
12JAK32.31136801
13NME22.30310709
14SIK12.29558932
15PTK2B2.18281036
16STK382.17094075
17DYRK1B2.16554775
18MAP3K112.02367544
19MAP3K21.94543757
20MAP2K31.85066053
21WNK41.83348349
22IRAK41.74723365
23STK391.74244562
24SMG11.68732158
25EEF2K1.65819860
26NEK21.57428257
27ILK1.44116383
28EPHA21.42737795
29MAPK151.42032322
30RPS6KC11.37608832
31RPS6KL11.37608832
32PDK11.32481579
33PNCK1.22872376
34TNK21.22015217
35BLK1.19714319
36PKN21.18897181
37RPS6KA61.16057640
38DYRK31.00592305
39STK38L0.99955809
40ZAP700.99709744
41CAMK1D0.97798197
42DDR20.96576759
43TYRO30.96428068
44MAP3K10.92343821
45PIM20.88607741
46PDPK10.88495572
47MAP3K140.87005467
48CDC42BPA0.85839067
49RPS6KB20.85245808
50MAP3K130.85162750
51IRAK10.83570118
52MATK0.83340046
53CAMK40.80704572
54FGFR40.79252143
55MAP2K60.76289014
56PRKD20.75603923
57RIPK10.73256817
58WNK10.73209381
59MAPK110.72482501
60FGR0.70113650
61STK30.69210767
62GRK60.66383015
63RIPK40.65683327
64MAP3K100.64486823
65PASK0.64158203
66CSF1R0.63444188
67TRPM70.63402901
68BMX0.62934518
69SIK30.61288715
70PKN10.57809777
71TBK10.56149921
72PDGFRA0.56088543
73MAP4K10.54873232
74MAPK120.53353948
75CAMK10.53175312
76TTK0.52883088
77ARAF0.52547181
78KSR20.50811364
79IKBKE0.50537627
80NEK90.49995840
81MAPKAPK30.49825295
82IRAK20.49072389
83TGFBR20.48752677
84MST1R0.48625281
85BTK0.46685571
86PAK10.45794184
87PAK40.44872385
88CCNB10.43987967
89CDK90.43802561
90EPHB10.42840015
91PAK20.42444335
92CHEK20.41456061
93CAMK1G0.41063155
94CAMKK20.40832402
95SIK20.38874266
96PRKAA20.37068422
97CHEK10.36367661
98MAP2K20.35984227
99TESK20.35958318
100IKBKB0.35407023
101BCKDK0.35390546
102MOS0.34914751
103TAOK20.34646568
104PRKCZ0.33250672
105PINK10.32567803
106GRK70.32509103
107PRKAA10.32441286
108SYK0.32307460
109MAPKAPK50.32282233
110MTOR0.31764704
111RPS6KA10.31127729
112PRKCQ0.29595083
113STK110.28826803
114TRIB30.28745313
115PIM10.27629603
116CSK0.26478515
117ERBB30.26378579
118MUSK0.26164366
119TYK20.26013136
120NTRK20.25322132
121PRKCG0.24816415
122MARK20.21323394
123PAK30.20813409
124ATM0.20694109
125PRKCD0.20029592
126RPS6KB10.19689218
127CHUK0.19226090
128PTK60.17536117
129ATR0.14400552
130EGFR0.13948793
131LMTK20.13477011
132STK100.13051721
133CDK120.12746350
134MAP3K50.12697542
135FRK0.12402833
136RPS6KA20.11857727
137MAP3K80.09191044
138CDK60.08080419
139MARK30.07704917
140TTN0.07227603
141INSR0.06661730
142PRKACG0.06513476
143PRKG20.05201332
144CAMKK10.04855579
145MAPKAPK20.04016548
146JAK10.03494786
147GSK3B0.03239088
148CDK40.02658649
149NUAK10.01493655
150PRKCB0.00729787
151FGFR30.00373406
152KIT0.00212547
153CSNK2A1-0.0263823
154MAPK1-0.0258410
155TAOK1-0.0133323
156HCK-0.0121653
157MAPK8-0.0106378
158CSNK1D-0.0013920

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.08502341
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.04091284
3Other glycan degradation_Homo sapiens_hsa005113.95993362
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.42908889
5Linoleic acid metabolism_Homo sapiens_hsa005913.20563111
6Olfactory transduction_Homo sapiens_hsa047402.59520562
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.58931995
8Pyruvate metabolism_Homo sapiens_hsa006202.50762983
9Vitamin B6 metabolism_Homo sapiens_hsa007502.42997199
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.36302528
11Glucagon signaling pathway_Homo sapiens_hsa049222.36034461
12Lysosome_Homo sapiens_hsa041422.34085720
13Propanoate metabolism_Homo sapiens_hsa006402.12926876
14Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.07870957
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.03566296
16Glycerolipid metabolism_Homo sapiens_hsa005612.00731447
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042132.00117747
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.99735592
19Leishmaniasis_Homo sapiens_hsa051401.99087081
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.97178645
21Acute myeloid leukemia_Homo sapiens_hsa052211.95962319
22PPAR signaling pathway_Homo sapiens_hsa033201.90836428
23Fatty acid metabolism_Homo sapiens_hsa012121.86722073
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.85053351
25Antigen processing and presentation_Homo sapiens_hsa046121.74552022
26Fat digestion and absorption_Homo sapiens_hsa049751.73885086
27Selenocompound metabolism_Homo sapiens_hsa004501.70630548
28Fructose and mannose metabolism_Homo sapiens_hsa000511.69650687
29Glycerophospholipid metabolism_Homo sapiens_hsa005641.69502842
30Bladder cancer_Homo sapiens_hsa052191.68187295
31Tuberculosis_Homo sapiens_hsa051521.67980368
32Dorso-ventral axis formation_Homo sapiens_hsa043201.64644520
33TNF signaling pathway_Homo sapiens_hsa046681.62911673
34Fatty acid degradation_Homo sapiens_hsa000711.52015847
35Basal transcription factors_Homo sapiens_hsa030221.48212243
36Staphylococcus aureus infection_Homo sapiens_hsa051501.47428273
37Pertussis_Homo sapiens_hsa051331.45361859
38Chronic myeloid leukemia_Homo sapiens_hsa052201.43807371
39Ether lipid metabolism_Homo sapiens_hsa005651.43320394
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40322237
41Malaria_Homo sapiens_hsa051441.39850243
42Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31043259
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29791613
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.28704179
45Non-small cell lung cancer_Homo sapiens_hsa052231.26097441
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.25854683
47Amphetamine addiction_Homo sapiens_hsa050311.25453529
48Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23961623
49Adipocytokine signaling pathway_Homo sapiens_hsa049201.23835571
50Arginine biosynthesis_Homo sapiens_hsa002201.23592633
51Hepatitis B_Homo sapiens_hsa051611.22170844
52Hepatitis C_Homo sapiens_hsa051601.20497049
53Sphingolipid signaling pathway_Homo sapiens_hsa040711.20065709
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.19319647
55Phagosome_Homo sapiens_hsa041451.18232713
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.18031451
57Notch signaling pathway_Homo sapiens_hsa043301.17589423
58Prion diseases_Homo sapiens_hsa050201.14146832
59Rheumatoid arthritis_Homo sapiens_hsa053231.13500696
60Renal cell carcinoma_Homo sapiens_hsa052111.13368607
61NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12287485
62Mineral absorption_Homo sapiens_hsa049781.09334983
63Oocyte meiosis_Homo sapiens_hsa041141.09066467
64Pentose phosphate pathway_Homo sapiens_hsa000301.07053347
65Renin secretion_Homo sapiens_hsa049241.05936260
66AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05393626
67Shigellosis_Homo sapiens_hsa051311.04552535
68mTOR signaling pathway_Homo sapiens_hsa041501.04436965
69Pancreatic cancer_Homo sapiens_hsa052121.03413408
70Legionellosis_Homo sapiens_hsa051341.02864063
71Apoptosis_Homo sapiens_hsa042101.01588465
72Insulin signaling pathway_Homo sapiens_hsa049100.99863082
73Systemic lupus erythematosus_Homo sapiens_hsa053220.99723298
74Cardiac muscle contraction_Homo sapiens_hsa042600.99254861
75Carbon metabolism_Homo sapiens_hsa012000.98338448
76Allograft rejection_Homo sapiens_hsa053300.98015879
77T cell receptor signaling pathway_Homo sapiens_hsa046600.97907738
78Herpes simplex infection_Homo sapiens_hsa051680.97178218
79Graft-versus-host disease_Homo sapiens_hsa053320.96923146
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94996402
81Arachidonic acid metabolism_Homo sapiens_hsa005900.94528881
82Pancreatic secretion_Homo sapiens_hsa049720.94463474
83Purine metabolism_Homo sapiens_hsa002300.93828179
84Amoebiasis_Homo sapiens_hsa051460.91317195
85Hematopoietic cell lineage_Homo sapiens_hsa046400.90770677
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.89860903
87Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89486234
88Viral myocarditis_Homo sapiens_hsa054160.89268530
89Chemokine signaling pathway_Homo sapiens_hsa040620.88132587
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.84402021
91Thyroid hormone synthesis_Homo sapiens_hsa049180.84304990
92Insulin secretion_Homo sapiens_hsa049110.84236728
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.84169413
94Galactose metabolism_Homo sapiens_hsa000520.83979780
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.83825441
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82374917
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.81283286
98Estrogen signaling pathway_Homo sapiens_hsa049150.80797471
99Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78675571
100Lysine degradation_Homo sapiens_hsa003100.78545512
101Jak-STAT signaling pathway_Homo sapiens_hsa046300.78529562
102Hedgehog signaling pathway_Homo sapiens_hsa043400.78273563
103Primary immunodeficiency_Homo sapiens_hsa053400.77762029
104Bile secretion_Homo sapiens_hsa049760.76820391
105Autoimmune thyroid disease_Homo sapiens_hsa053200.76324749
106African trypanosomiasis_Homo sapiens_hsa051430.76148159
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74474546
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74176467
109mRNA surveillance pathway_Homo sapiens_hsa030150.73317763
110N-Glycan biosynthesis_Homo sapiens_hsa005100.72670897
111Prolactin signaling pathway_Homo sapiens_hsa049170.71316073
112Glioma_Homo sapiens_hsa052140.71027603
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69012225
114HTLV-I infection_Homo sapiens_hsa051660.68892896
115Protein digestion and absorption_Homo sapiens_hsa049740.68844726
116Endometrial cancer_Homo sapiens_hsa052130.67325521
117Fanconi anemia pathway_Homo sapiens_hsa034600.66217345
118cAMP signaling pathway_Homo sapiens_hsa040240.66045119
119Intestinal immune network for IgA production_Homo sapiens_hsa046720.65234437
120GnRH signaling pathway_Homo sapiens_hsa049120.65089858
121AMPK signaling pathway_Homo sapiens_hsa041520.64672862
122Toxoplasmosis_Homo sapiens_hsa051450.63955728
123Vibrio cholerae infection_Homo sapiens_hsa051100.63599689
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63147103
125Small cell lung cancer_Homo sapiens_hsa052220.62475973
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.62342008
127Platelet activation_Homo sapiens_hsa046110.61291493
128Proteoglycans in cancer_Homo sapiens_hsa052050.59243119
129Glutathione metabolism_Homo sapiens_hsa004800.59143920
130Asthma_Homo sapiens_hsa053100.58437533
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58031887
132Cyanoamino acid metabolism_Homo sapiens_hsa004600.57973578
133Chemical carcinogenesis_Homo sapiens_hsa052040.57506515
134Salivary secretion_Homo sapiens_hsa049700.57477748
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57204477
136Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56452621
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.56284887
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55292887
139Endocytosis_Homo sapiens_hsa041440.55124588
140ABC transporters_Homo sapiens_hsa020100.54825679
141Sulfur relay system_Homo sapiens_hsa041220.54734905
142B cell receptor signaling pathway_Homo sapiens_hsa046620.54007313
143Sphingolipid metabolism_Homo sapiens_hsa006000.53800495
144ErbB signaling pathway_Homo sapiens_hsa040120.53799386
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.53192738
146RNA transport_Homo sapiens_hsa030130.52502879
147Biosynthesis of amino acids_Homo sapiens_hsa012300.51187184
148Viral carcinogenesis_Homo sapiens_hsa052030.49904820
149Alcoholism_Homo sapiens_hsa050340.49183366
150Vascular smooth muscle contraction_Homo sapiens_hsa042700.44630173
151Gastric acid secretion_Homo sapiens_hsa049710.44462939
152Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.43170347
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42503110
154Calcium signaling pathway_Homo sapiens_hsa040200.41747316
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39985611
156Phototransduction_Homo sapiens_hsa047440.37800705
157Influenza A_Homo sapiens_hsa051640.36883342
158Measles_Homo sapiens_hsa051620.36732896
159Insulin resistance_Homo sapiens_hsa049310.35850762
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33473898
161Taste transduction_Homo sapiens_hsa047420.33134565
162Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32535710
163Long-term potentiation_Homo sapiens_hsa047200.32418552
164VEGF signaling pathway_Homo sapiens_hsa043700.32259931
165Epstein-Barr virus infection_Homo sapiens_hsa051690.30623057
166Renin-angiotensin system_Homo sapiens_hsa046140.28754941
167Osteoclast differentiation_Homo sapiens_hsa043800.23127172
168Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23050743
169Phosphatidylinositol signaling system_Homo sapiens_hsa040700.22280324
170NF-kappa B signaling pathway_Homo sapiens_hsa040640.20526123
171Phenylalanine metabolism_Homo sapiens_hsa003600.19446081
172Salmonella infection_Homo sapiens_hsa051320.18138812
173Huntingtons disease_Homo sapiens_hsa050160.17869447
174HIF-1 signaling pathway_Homo sapiens_hsa040660.17421893
175Inositol phosphate metabolism_Homo sapiens_hsa005620.15012516

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